© WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Editor: Michael Rowan; Editorial Board Chairs: Uwe Bornscheuer, Luis A. Oro, Bert Weckhuysen
Impact Factor: 4.724
ISI Journal Citation Reports © Ranking: 2015: 29/144 (Chemistry Physical)
Online ISSN: 1867-3899
Cover Picture: Whole-Cell One-Pot Biosynthesis of Azelaic Acid (ChemCatChem 4/2014)
Bacterial ozonolysis The cover picture shows the Escherichia coli whole-cell-based biosynthesis of azelaic acid from linoleic acid starting material, which is enabled by a three-step enzymatic cascade reaction. In their Full Paper on p. 1003 ff., K. B. Otte et al. investigate the simultaneous lipoxygenase and hydroperoxide lyase-catalyzed oxidation and cleavage reaction of linoleic acid, which is derived from the plant oxylipin metabolism. Adjustment of the in vivo expression levels of these enzymes with respect to the lipoxygenase activation behavior results in the development of a dual expression system. In combination with an additional endogenous E. coli dehydrogenase, the artificial pathway for the bioconversion of linoleic acid into azelaic acid is completed.