ChemCatChem

Cover image for Vol. 8 Issue 12

Editor: Michael Rowan; Editorial Board Chairs: Uwe Bornscheuer, Luis A. Oro, Bert Weckhuysen

Impact Factor: 4.724

ISI Journal Citation Reports © Ranking: 2015: 29/144 (Chemistry Physical)

Online ISSN: 1867-3899

Associated Title(s): Advanced Synthesis & Catalysis, Angewandte Chemie International Edition, Chemistry - A European Journal, ChemBioChem, ChemElectroChem, ChemPhysChem, ChemSusChem

6_04i/2014Inside Cover: Enantioselective Rearrangement Coupled with Water Addition: Direct Synthesis of Enantiomerically Pure Saturated Carboxylic Acids from α,β-Unsaturated Aldehydes (ChemCatChem 4/2014)

Lemony fresh: just add water The cover picture shows the direct one-pot transformation of prochiral citral to (S)-citronellic acid. In their Communication on p. 961 ff., T. Winkler, H. Gröger, and W. Hummel describe the transformation of α,β-unsaturated aldehydes to saturated carboxylic acids by C=C bond reduction catalyzed by an NADPH-dependent ene reductase towards a saturated aldehyde, which is then oxidized by aldehyde dehydrogenase to the corresponding carboxylic acid with regeneration of NADPH for the next catalytic cycle. The sole reagent water is incorporated into the product with perfect atom economy with >99 % conversion and >99 % ee.

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