© WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Editor: Michael Rowan; Editorial Board Chairs: Uwe Bornscheuer, Luis A. Oro, Bert Weckhuysen
Impact Factor: 4.724
ISI Journal Citation Reports © Ranking: 2015: 29/144 (Chemistry Physical)
Online ISSN: 1867-3899
Inside Cover: Enantioselective Rearrangement Coupled with Water Addition: Direct Synthesis of Enantiomerically Pure Saturated Carboxylic Acids from α,β-Unsaturated Aldehydes (ChemCatChem 4/2014)
Lemony fresh: just add water The cover picture shows the direct one-pot transformation of prochiral citral to (S)-citronellic acid. In their Communication on p. 961 ff., T. Winkler, H. Gröger, and W. Hummel describe the transformation of α,β-unsaturated aldehydes to saturated carboxylic acids by C=C bond reduction catalyzed by an NADPH-dependent ene reductase towards a saturated aldehyde, which is then oxidized by aldehyde dehydrogenase to the corresponding carboxylic acid with regeneration of NADPH for the next catalytic cycle. The sole reagent water is incorporated into the product with perfect atom economy with >99 % conversion and >99 % ee.