BioFactors

Cover image for Vol. 42 Issue 4

Edited By: Angelo Azzi

Impact Factor: 4.504

ISI Journal Citation Reports © Ranking: 2015: 26/131 (Endocrinology & Metabolism); 63/289 (Biochemistry & Molecular Biology)

Online ISSN: 1872-8081

Associated Title(s): Biochemistry and Molecular Biology Education, Biotechnology and Applied Biochemistry, IUBMB Life

Featured

  • Neferine prevents NF-κB translocation and protects muscle cells from oxidative stress and apoptosis induced by hypoxia

    Neferine prevents NF‐κB translocation and protects muscle cells from oxidative stress and apoptosis induced by hypoxia

    Nef pretreatment prevents apoptotic characteristics induced by hypoxic stress in muscle cells as evident from PI staining. After treatment period cells were stained with propidium iodide and observed under fluorescence microscope. Hypoxia treated cells show nuclear condensation and formation of apoptotic bodies. Magnification (400×).

  • Role of MAPK-mediated endoplasmic reticulum stress signaling in the heart during aging in senescence-accelerated prone mice

    Role of MAPK‐mediated endoplasmic reticulum stress signaling in the heart during aging in senescence‐accelerated prone mice

    Cardiomyocyte apoptosis analysis. A, TUNEL staining images showing fluorescent apoptotic nuclei in the sections of both SAMR1 and SAMP8 mice hearts. B, Immunohistochemical staining for cleaved caspase-3 in the heart sections of SAMR1 and SAMP8 mice (brown spots).

  • Expression of cell cycle proteins in cortical neurons—Correlation with glutamate-induced neurotoxicity

    Expression of cell cycle proteins in cortical neurons—Correlation with glutamate‐induced neurotoxicity

    Analysis of changes in cell morphology was evaluated using AO/EB vital staining assay and visualized by confocal microscopy. Cortical neurons were treated with increasing concentrations of glutamate for 24 h. After treatment, cells were double stained by AO/EB. Live cells are stained by AO have green nuclei. Dead cells are stained with EB have red nuclei. Apoptotic cells have fragmented nucleus and stained as yellow-orange (arrow).

  • CITA/NLRC5: A critical transcriptional regulator of MHC class I gene expression

    CITA/NLRC5: A critical transcriptional regulator of MHC class I gene expression

    MHC class I and class II antigen presentation for CD8+ and CD4+ T cells. (a) MHC class I molecules present antigens such as virus or tumor antigens that are mostly derived from proteins degraded in the cytosol by the immunoproteasome. Antigenic peptides are transported into the endoplasmic reticulum (ER) via TAP1/TAP2, where peptides are loaded onto the MHC class I complex, which is composed of a heavy chain and β2-microglobulin (β2m). MHC class I complexes loaded with antigens are transported to the cell surface and presented to CD8+ T cells. (b) MHC class II presents antigens from extracellular sources, such as bacterial antigens. Endosomes take up the antigen and fuse with lysosomes, which contain proteolytic enzymes that cleave the antigens into small peptides. These peptides bind to the groove of the MHC class II complex by displacing the class II-associated invariant chain peptide (CLIP), which is derived from the MHC class II-associated invariant chain (Ii). HLA-DO and HLA-DM regulate the antigen-loading process. The peptide loaded MHC class II complex is presented to CD4+ T cells. MIIC, MHC class II compartment; TAP, transporter associated with antigen processing; TCR, T cell receptor.

  • Neferine prevents NF‐κB translocation and protects muscle cells from oxidative stress and apoptosis induced by hypoxia
  • Role of MAPK‐mediated endoplasmic reticulum stress signaling in the heart during aging in senescence‐accelerated prone mice
  • Expression of cell cycle proteins in cortical neurons—Correlation with glutamate‐induced neurotoxicity
  • CITA/NLRC5: A critical transcriptional regulator of MHC class I gene expression

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IUBMB Journals Collection: Diabetes

2015 BioFactors Young Investigator Award

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On behalf of the IUBMB, BioFactors and Wiley, it is with great pleasure and honor that we announce Shilpa Thakur as the recipient of the 2015 BioFactors - Wiley Young Investigator Award for her article, Regulation at multiple levels controls the expression of folate transporters in liver cells in conditions of ethanol exposure and folate deficiency.

Shilpa Thakur is a Ph.D student in the Department of Biochemistry, Post Graduate Institute of Medical Education and Research, in Chandigarh, India. She completed her Bachelor’s and Masters' degree in Biotechnology and thereafter joined the Ph.D program under the guidance of Dr. Jyotdeep Kaur, Additional Professor in the Department of Biochemistry. As a part of her thesis work, Dr. Thakur has examined various regulatory mechanisms underlying the effects of folate deficiency and ethanol exposure on folate transport, and has gained expertise in the field of molecular biology and epigenetics during her Ph.D tenure. Presently, Dr. Thakur’s laboratory is focusing on folate deficiency and epigenetic regulation of some imprinting genes.

Shilpa Thakur will be honored with the 2015 BioFactors - Wiley Young Investigator Award at the 23rd International Union for Biochemistry and Molecular Biology (IUBMB) Congress and 44th Annual Meeting of the Brazilian Society for Biochemistry and Molecular Biology in Foz do Iguaçu, Brazil from August 24th to 28th, 2015, and her award-winning article will be FREELY available online through the conference.

Please join us in congratulating Shipla Thakur as the recipient of the annual BioFactors– Wiley Young Investigator Award!

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2015 Impact Factor:
BioFactors is pleased to announce its 2015 Impact Factor of 4.504

2016 Release of Journal Citation Reports®
Source: Thomson Reuters 2015 Citation Data

Open Access Highlight

Quantification of age-related changes of α-tocopherol in lysosomal membranes in murine tissues and human fibroblasts
Jeannette König, Fabian Besoke, Wolfgang Stuetz, Angelika Malarski, Gerhard Jahreis, Tilman Grune and Annika Höhn

IUBMB Joint Virtual Issue on Cancer Therapies

BTPR online only


We’re pleased to present a new Joint Virtual Issue on Cancer Therapies in celebration of the IUBMB 2015 Miami Winter Symposium, featuring articles from Biofactors, Biotechnology and Applied Biochemistry, and IUBMB Life.

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