BioFactors

Cover image for Vol. 40 Issue 1

Edited By: Angelo Azzi

Impact Factor: 3.088

ISI Journal Citation Reports © Ranking: 2012: 53/122 (Endocrinology & Metabolism); 124/290 (Biochemistry & Molecular Biology)

Online ISSN: 1872-8081

Associated Title(s): Biochemistry and Molecular Biology Education, Biotechnology and Applied Biochemistry, IUBMB Life

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  • Biochemical and molecular mechanisms for the association between obesity, chronic Inflammation, and breast cancer

    Biochemical and molecular mechanisms for the association between obesity, chronic Inflammation, and breast cancer

    Obesity and the molecular mechanisms for leptin regulation of the cell cycle, cell proliferation and survival (antiapoptosis), and angiogenesis, mainly involve the activation of NF-κB through canonic (PI3K/Akt/mTOR and MAPK/ERK), and non-canonic (JNK, p38, and PKC) signaling pathways. Leptin activation of PKC may be up-stream of the MAPK/ERK1/2 and p38 kinases (dotted line). In addition, leptin binding to its receptors activates JAK2, with phosphorylation of STAT3 that allows for its dimerization. The STAT3 dimer then translocates to the nucleus where it regulates transcription. Abbreviations: PI3K, phosphatidylinositol 3-kinase; MAPK, mitogen-activated protein kinase; ERK, extracellular signal-regulated kinases; JAK, Janus kinase; JNK, Jun N-terminal kinase; Akt, protein kinase B; mTOR, mammalian target of rapamycin; STAT, signal transducer and activator of transcription; NF-κB, nuclear factor κ-light chain-enhancer of activated B cells.

  • Ghrelin and bone

    Ghrelin and bone

    Overview of the relationships between ghrelin, leptin, and the GH–IGF-I axis in regulating bone metabolism. Absorption of calcium, phosphates, and other nutrients by the gut provides the building blocks for bone formation. Ghrelin, leptin, GH, IGF-I, and other factors sense the availability of nutrients, and the body's energy requirements, and integrate this information to regulate bone metabolism. Ghrelin, leptin, GH, and IGF–I all appear to have direct and indirect effects on bone at both paracrine and endocrine levels.

  • Immunopathological effects of malaria pigment or hemozoin and other crystals

    Immunopathological effects of malaria pigment or hemozoin and other crystals

    Phagocytosis of Hz does not result in phagolysosome destabilization. A: In monocytes fed with nHz, Hz fluorescence (red, A2) colocalizes with an indicator of acidic organelles (green, A1) as shown in the merged image (A3), showing that Hz does not lead to disruption of the phagolysosomal membrane (magnification: 3,500×). B: Colocalization of Hz (left images) and acidic organelles (right images) was shown at different times after the start of phagocytosis (B1, 1 h; B2, 2 h; B3, 12 h; and B4, 72 h). The images are in false colors reflecting the fluorescence intensity (white > red > green > blue; magnification: 2,400×). Reprinted from Ref. 51 with permission from Cambridge University Press.

  • Neferine, an alkaloid from lotus seed embryo, inhibits human lung cancer cell growth by MAPK activation and cell cycle arrest

    Neferine, an alkaloid from lotus seed embryo, inhibits human lung cancer cell growth by MAPK activation and cell cycle arrest

    A549 cells were treated with different concentrations of neferine and loaded with fura-2/AM. (a) Treatment with neferine increased intracellular Ca2+ levels in a dose-dependent manner. (b) Neferine induced significant level of Mn2+ influx. Results shown are mean ± SEM, which are three separate experiments performed in triplicate. ***The groups that differ significantly at P < 0.01 from control. (c) It was observed that neferine could induce mitochondrial damage as high as CCCP.

  • Dose-dependent bioavailability indicators for curcumin and two of its novel derivatives

    Dose‐dependent bioavailability indicators for curcumin and two of its novel derivatives

    Percent increase in plasma levels of GST (U/L). *Values differ significantly from curcumin (P < 0.05). #Values differ significantly from NCD-1 (P < 0.05).

  • Omega-3 polyunsaturated fatty acids and proanthocyanidins improve postprandial metabolic flexibility in rat

    Omega‐3 polyunsaturated fatty acids and proanthocyanidins improve postprandial metabolic flexibility in rat

    Creatine kinase plasma values and ROS production in skeletal muscle. A: Creatine kinase values were measured in plasma. B: ROS production was measured with cell-permeant DCFH-DA in a homogenized preparation of skeletal muscle. Experimental details as in Table . Each value is the mean ± SEM of six animals per group. The letters a, b indicate significant differences (P < 0.05) between groups by ANOVA analysis.

  • Regulation of HA14-1 mediated oxidative stress, toxic response, and autophagy by curcumin to enhance apoptotic activity in human embryonic kidney cells

    Regulation of HA14‐1 mediated oxidative stress, toxic response, and autophagy by curcumin to enhance apoptotic activity in human embryonic kidney cells

    Changes in mitochondrial membrane potential (MMP). HEK 293T cells were grown on poly L-lysine treated coverslip and treated with 5 μM of HA14-1 alone for 30-180 min and pretreated with 10 μM of curcumin for 1 h (shown as 0 min time point) followed by incubation with 5 μM of HA14-1 for 30-180 min. After completion of incubation cells were stained with JC-1 (5μg/ml) and counterstained with DAPI (1μg/ml). More than 200 cells from three random fields were analyzed under the laser scanning confocal microscope. Scale bar represents 2μm. (a) Changes in MMP when cells were treated with 5 μM of HA14-1 alone for 30-180 min. (b) Changes in MMP when cells were pretreated with 10 μM of curcumin for 1 h followed by incubation with 5 μM of HA14- for 30-180 min. (c) Quantitative analysis of loss of mitochondrial membrane potential by measuring the fluorescence intensity of JC-1 at Ex- 540 and Em- 485 nm using multimode plate reader. Error bars represent mean ±SEM from three independent experiments. The P value indicates *P ≤ 0.05.

  • Biochemical and molecular mechanisms for the association between obesity, chronic Inflammation, and breast cancer
  • Ghrelin and bone
  • Immunopathological effects of malaria pigment or hemozoin and other crystals
  • Neferine, an alkaloid from lotus seed embryo, inhibits human lung cancer cell growth by MAPK activation and cell cycle arrest
  • Dose‐dependent bioavailability indicators for curcumin and two of its novel derivatives
  • Omega‐3 polyunsaturated fatty acids and proanthocyanidins improve postprandial metabolic flexibility in rat
  • Regulation of HA14‐1 mediated oxidative stress, toxic response, and autophagy by curcumin to enhance apoptotic activity in human embryonic kidney cells

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Wilfred Chen

On behalf of the IUBMB, BioFactors, and Wiley, it is with great pleasure and honor that we announce Dr. Iziar Ludwig as the first recipient of the BioFactors - Wiley Young Investigator Award for her article, Catabolism of coffee chlorogenic acids by human colonic microbiota, available FREE.

Dr. Ludwig defended her PhD thesis at the University of Navarra (Spain) under the supervision of Dr. Maria-Paz de Peña and is now a postdoc at the University of Glasgow.

Please join us in congratulating Dr. Ludwig as the first recipient of the annual BioFactors Wiley Young Investigator Award!

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