BioFactors

Cover image for Vol. 42 Issue 2

Edited By: Angelo Azzi

Impact Factor: 4.592

ISI Journal Citation Reports © Ranking: 2014: 26/128 (Endocrinology & Metabolism); 60/290 (Biochemistry & Molecular Biology)

Online ISSN: 1872-8081

Associated Title(s): Biochemistry and Molecular Biology Education, Biotechnology and Applied Biochemistry, IUBMB Life

Featured

  • Cinnamaldehyde supplementation prevents fasting-induced hyperphagia, lipid accumulation, and inflammation in high-fat diet-fed mice

    Cinnamaldehyde supplementation prevents fasting‐induced hyperphagia, lipid accumulation, and inflammation in high‐fat diet‐fed mice

    Schematic diagram depicting the possible mode of action of cinnamaldehyde in high-fat diet-fed mice. Daily oral administration of CMN prevented HFD-induced weight gain. CMN decreased HFD-induced hyperphagia via modulation of hypothalamic anorectic genes; directly increases lipolysis in adipose tissue; activates BAT activity; and decrease adipose tissue inflammation. GPD, glycerol-3-phosphate dehydrogenase; PLIN1, perilipin.

  • Mitochondrial ascorbic acid prevents mitochondrial O2.− formation, an event critical for U937 cell apoptosis induced by arsenite through both autophagic-dependent and independent mechanisms

    Mitochondrial ascorbic acid prevents mitochondrial O2.− formation, an event critical for U937 cell apoptosis induced by arsenite through both autophagic‐dependent and independent mechanisms

    Effects of 3-MA, Chl or Rapa on arsenite-induced autophagy and toxicity. (A) Cells were pre-exposed to 1 mM 3-MA (1 h), 10 µM Chl (1 h) or 100 nM Rapa (4 h) and subsequently grown for an additional 36 h in the presence of arsenite. After treatments, the cells were analyzed for MDC staining. (B) Counts of cells exposed for increasing time intervals to arsenite in with or without addition of 3-MA, Chl or Rapa. Results represent the means ± SD calculated from at least 3 separate experiments. *P < 0.01, as compared with cells treated with arsenite (two-way ANOVA followed by Bonferroni's test).

  • Prophylactic and abundant intake of α-lipoic acid causes hepatic steatosis and should be reconsidered in usage as an anti-aging drug

    Prophylactic and abundant intake of α‐lipoic acid causes hepatic steatosis and should be reconsidered in usage as an anti‐aging drug

    Schematic illustration of the effect of short-term (A) and long-term (B) ALA intake on hepatic lipid metabolism. In case of short-term ALA treatment the glycolysis, the β-oxidation and the de novo lipogenesis are markedly increased, while the parallel increase of lipolytic parameters turned out into a rise of lxrα and rxrα mRNA expression, causing slight hepatic lipid accumulation and increased oxidative stress (A). Long-term ALA treatment caused also an increase of β-oxidation and of glycolysis, however de novo lipogenesis is strongly enhanced because of the rise of mRNA expression of srebp1c and fas. This lead to a marked accumulation of lipids and further to liver injury, indicated by increased inflammation and disruption of the general hepatic architecture.

  • Inhibition of succinate dehydrogenase sensitizes cyclin E-driven ovarian cancer to CDK inhibition

    Inhibition of succinate dehydrogenase sensitizes cyclin E‐driven ovarian cancer to CDK inhibition

    Ovarian cancer cells exhibited high expression of SDH genes in general. Reproduced from the CCLE dataset with heatmap generated by the GENE-E, SDHA was upregulated in almost all ovarian cancer cells. Some of the Cyclin E-driven cell lines like A2780 showed solely moderate upregulation of SDHA, which is representative to our metabolic shift model and the clinical phenotype with constitutive CCNE upregulation and unchanged SDHA.

  • Tocotrienol and cancer metastasis

    Tocotrienol and cancer metastasis

    A. Surveillance, Epidemiology, and End Results (SEER) program top 15 highest cancer-related mortality rates based on primary tumor sites. Top 15 cancer sites were selected based on 2008 to 2012 age-adjusted rates for all races/ethnic group. B. Surveillance, Epidemiology, and End Results (SEER) program stage distribution of solid tumors at diagnosis. Incidence source were collected from 18 SEER areas in the United States. Stage distribution include only female data for breast and ovary cancers and only male data for prostate cancer. IBD = intrahepatic bile duct. ONS = other nervous system.

  • Cardiac troponins—Translational biomarkers in cardiology: Theory and practice of cardiac troponin high-sensitivity assays

    Cardiac troponins—Translational biomarkers in cardiology: Theory and practice of cardiac troponin high‐sensitivity assays

    Structure and localization of troponin complex.

  • Cinnamaldehyde supplementation prevents fasting‐induced hyperphagia, lipid accumulation, and inflammation in high‐fat diet‐fed mice
  • Mitochondrial ascorbic acid prevents mitochondrial O2.− formation, an event critical for U937 cell apoptosis induced by arsenite through both autophagic‐dependent and independent mechanisms
  • Prophylactic and abundant intake of α‐lipoic acid causes hepatic steatosis and should be reconsidered in usage as an anti‐aging drug
  • Inhibition of succinate dehydrogenase sensitizes cyclin E‐driven ovarian cancer to CDK inhibition
  • Tocotrienol and cancer metastasis
  • Cardiac troponins—Translational biomarkers in cardiology: Theory and practice of cardiac troponin high‐sensitivity assays

Recently Published Issues

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IUBMB Joint Virtual Issue on Cancer Therapies

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We’re pleased to present a new Joint Virtual Issue on Cancer Therapies in celebration of the IUBMB 2015 Miami Winter Symposium, featuring articles from Biofactors, Biotechnology and Applied Biochemistry, and IUBMB Life.

2015 BioFactors Young Investigator Award

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On behalf of the IUBMB, BioFactors and Wiley, it is with great pleasure and honor that we announce Shilpa Thakur as the recipient of the 2015 BioFactors - Wiley Young Investigator Award for her article, Regulation at multiple levels controls the expression of folate transporters in liver cells in conditions of ethanol exposure and folate deficiency.

Shilpa Thakur is a Ph.D student in the Department of Biochemistry, Post Graduate Institute of Medical Education and Research, in Chandigarh, India. She completed her Bachelor’s and Masters' degree in Biotechnology and thereafter joined the Ph.D program under the guidance of Dr. Jyotdeep Kaur, Additional Professor in the Department of Biochemistry. As a part of her thesis work, Dr. Thakur has examined various regulatory mechanisms underlying the effects of folate deficiency and ethanol exposure on folate transport, and has gained expertise in the field of molecular biology and epigenetics during her Ph.D tenure. Presently, Dr. Thakur’s laboratory is focusing on folate deficiency and epigenetic regulation of some imprinting genes.

Shilpa Thakur will be honored with the 2015 BioFactors - Wiley Young Investigator Award at the 23rd International Union for Biochemistry and Molecular Biology (IUBMB) Congress and 44th Annual Meeting of the Brazilian Society for Biochemistry and Molecular Biology in Foz do Iguaçu, Brazil from August 24th to 28th, 2015, and her award-winning article will be FREELY available online through the conference.

Please join us in congratulating Shipla Thakur as the recipient of the annual BioFactors– Wiley Young Investigator Award!

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IUBMB Journals Collection: Diabetes

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2014 Impact Factor:
BioFactors is pleased to announce its 2014 Impact Factor has increased to 4.592!

2015 Release of Journal Citation Reports®
Source: Thomson Reuters 2014 Citation Data

Open Access Highlight

Click below to read this OnlineOpen Review Article in BioFactors for FREE:

Novel insights on interactions between folate and lipid metabolism
Robin P. da Silva, Karen B. Kelly, Ala Al Rajabi, René L. Jacobs
Volume 40, Issue 3, May/June 2014

Folate is an essential B vitamin required for the maintenance of AdoMet-dependent methylation. The liver is responsible for many methylation reactions that are used for post-translational modifications of proteins, methylation of DNA, and the synthesis of hormones, creatine, carnitine, and phosphatidylcholine. Conditions where methylation capacity is compromised, including folate deficiency, are associated with impaired phospatidylcholine synthesis resulting in non-alcoholic fatty liver disease and steatohepatitis. Read the full article FREE!

Now in EarlyView

Fructooligosaccharides suppress high-fat diet-induced fat accumulation in C57BL/6J mice
Yuko Nakamura, Midori Natsume, Akiko Yasuda, Mihoko Ishizaka, Keiko Kawahata, Jinichiro Koga

Alterations in human muscle protein metabolism with aging: Protein and exercise as countermeasures to offset sarcopenia
Tyler A. Churchward-Venne, Leigh Breen, Stuart M. Phillips

Mitochondrial ascorbic acid is responsible for enhanced susceptibility of U937 cells to the toxic effects of peroxynitrite
Andrea Guidarelli, Liana Cerioni, Mara Fiorani, Catia Azzolini, Orazio Cantoni

ATP-binding cassette transporters in live
Katrin Wlcek, Bruno Stieger

A DAF-16/FoxO3a-dependent longevity signal is initiated by antioxidants
Juewon Kim, Naoko Ishihara, Tae Ryong Lee

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