European Journal of Heart Failure

Cover image for Vol. 19 Issue 5

Edited By: Prof. Marco Metra

Impact Factor: 5.135

ISI Journal Citation Reports © Ranking: 2015: 17/124 (Cardiac & Cardiovascular Systems)

Online ISSN: 1879-0844

Associated Title(s): ESC Heart Failure

Virtual Issues


List of EJHF Virtual Issues



Heart Failure Awareness Day Virtual Issue

From ESC Heart Failure

Heart failure awareness survey in Germany: general knowledge on heart failure remains poor
Christine Zelenak, Sara Radenovic, Lindy Musial-Bright, Elvis Tahirovic, Mesud Sacirovic, Chong-Bin Lee, Diana Jahandar-Lashki, Simone Inkrot, Tobias Daniel Trippel, Andreas Busjahn, Djawid Hashemi, Rolf Wachter, Sabine Pankuweit, Stefan Störk, Burkert Pieske, Frank Edelmann and Hans-Dirk Düngen

Sexual function of patients with heart failure: facts and numbers
Tiny Jaarsma
ESC Heart Failure, Volume 4, Issue 1, February 2017, Pages 3–7

Heart failure: preventing disease and death worldwide
Piotr Ponikowski, Stefan D. Anker, Khalid F. AlHabib, Martin R. Cowie, Thomas L. Force, Shengshou Hu, Tiny Jaarsma, Henry Krum, Vishal Rastogi, Luis E. Rohde, Umesh C. Samal, Hiroaki Shimokawa, Bambang Budi Siswanto, Karen Sliwa and Gerasimos Filippatos
ESC Heart Failure, Volume 1, Issue 1, September 2014, Pages 4–25

Relationship of physical activity and healthy eating with mortality and incident heart failure among community-dwelling older adults with normal body mass index
Ahmed Abdelmawgoud, Cynthia J. Brown, Xuemei Sui, Gregg C. Fonarow, Peter F. Kokkinos, Vera Bittner, Wilbert S. Aronow, Raya E. Kheirbek, Ross D. Fletcher, Steven N. Blair and Ali Ahmed
ESC Heart Failure, Volume 2, Issue 1, March 2015, Pages 20–24

Obesity paradox in heart failure: a heavy matter
Vijaiganesh Nagarajan, Luke Kohan, Eric Holland, Ellen C. Keeley and Sula Mazimba
ESC Heart Failure, Volume 3, Issue 4, December 2016, Pages 227–234

Acute heart failure facts and numbers: acute heart failure populations
Julia Searle, Johann Frick and Martin Möckel
ESC Heart Failure, Volume 3, Issue 2, June 2016, Pages 65–70

The effect of exercise training on biventricular myocardial strain in heart failure with preserved ejection fraction
Siddhartha S. Angadi, Catherine L. Jarrett, Moustafa Sherif, Glenn A. Gaesser and Farouk Mookadam


From European Journal of Heart Failure

What does the lay public know about heart failure? Findings from the Heart Failure Awareness Day Initiative
Stefan Störk, Ausra Kavoliuniene, Dragos Vinereanu, Rafael Ludwig, Petar Seferovic, Kenneth Dickstein, Stefan D. Anker, Gerasimos Filippatos, Pjotr Ponikowski and Mitja Lainscak

ExtraHF survey: the first European survey on implementation of exercise training in heart failure patients
Massimo F. Piepoli, Simone Binno, Ugo Corrà, Petar Seferovic, Viviane Conraads, Tiny Jaarsma, Jean-Paul Schmid, Gerasimos Filippatos, Piotr P. Ponikowski and on behalf of the Committee on Exercise Physiology & Training of the Heart Failure Association of the ESC

Adherence to a Mediterranean diet is associated with reduced risk of heart failure in men
Thanasis G. Tektonidis, Agneta Åkesson, Bruna Gigante, Alicja Wolk and Susanna C. Larsson

Fruit and vegetable intake and rate of heart failure: a population-based prospective cohort of women
Susanne Rautiainen, Emily B. Levitan, Murray A. Mittleman and Alicja Wolk

Mediterranean diet and risk of heart failure: results from the PREDIMED randomized controlled trial
Angeliki Papadaki, Miguel Ángel Martínez-González, Angel Alonso-Gómez, Javier Rekondo, Jordi Salas-Salvadó, Dolores Corella, Emilio Ros, Montse Fitó, Ramon Estruch, José Lapetra, Antonio García-Rodriguez, Miquel Fiol, Lluís Serra-Majem, Xavier Pintó, Miguel Ruiz-Canela, Monica Bulló, Mercè Serra-Mir, Jose V. Sorlí and Fernando Arós

Influence of cigarette smoking on cardiac biomarkers: the Atherosclerosis Risk in Communities (ARIC) Study
Wilson Nadruz Jr, Alexandra Gonçalves, Brian Claggett, Gabriela Querejeta Roca, Amil M. Shah, Susan Cheng, Gerardo Heiss, Christie M. Ballantyne and Scott D. Solomon


Heart Failure Conference Reads

From ESC Heart Failure

Cardiac and peripheral autonomic control in restrictive cardiomyopathy
Ana Luiza C. Sayegh, Marcelo R. dos Santos, Adriana O. Sarmento, Francis R. de Souza, Vera M.C. Salemi, Viviane T. Hotta, Akothirene Cristhina D.B. Marques, Heidrum H. Krämer, Ivani C. Trombetta, Charles Mady and Maria Janieire de Nazaré Nunes Alves

Translational Registry for CardiomyopatHies (TORCH) – rationale and first results
Claudia Seyler, Benjamin Meder, Tanja Weis, Thea Schwaneberg, Kerstin Weitmann, Wolfgang Hoffmann, Hugo A. Katus and Andreas Dösch

Palliative care in heart failure: facts and numbers
Jillian P. Riley and James M. Beattie

Who are patients classified within the new terminology of heart failure from the 2016 ESC guidelines?
Benoit Delepaul, Guillaume Robin, Clément Delmas, Thomas Moine, Adrien Blanc, Pauline Fournier, Aénora Roger-Rollé, Guillaume Domain, Clémence Delon, Charles Uzan, Rabah Boudjellil, Didier Carrié, Jérôme Roncalli, Michel Galinier and Olivier Lairez

Serum albumin level and hospital mortality in acute non-ischemic heart failure
Arnaud Ancion, Sophie Allepaerts, Cécile Oury, Anne-Stephan Gori, Luc A. Piérard and Patrizio Lancellotti

Uric acid predicts mortality and ischaemic stroke in subjects with diastolic dysfunction: the Tromsø Study 1994–2013
Jon V. Norvik, Henrik Schirmer, Kirsti Ytrehus, Hilde M. Storhaug, Trond G. Jenssen, Bjørn O. Eriksen, Ellisiv B. Mathiesen, Maja-Lisa Løchen, Tom Wilsgaard and Marit D. Solbu

On admission serum sodium and uric acid levels predict 30 day rehospitalization or death in patients with acute decompensated heart failure
Ahmad Amin, Mitra Chitsazan, Fatemeh Shiukhi Ahmad Abad, Sepideh Taghavi and Nasim Naderi

Periodontitis and bone metabolism in patients with advanced heart failure and after heart transplantation
Ulrike Schulze-Späte, Iman Mizani, Kristina Rodriguez Salaverry, Jaime Chang, Christina Wu, Meaghan Jones, Peter J. Kennel, Danielle L. Brunjes, Tse-Hwei Choo, Tomoko S. Kato, Donna Mancini, John Grbic and P. Christian Schulze

Metabolic profiles in heart failure due to non-ischemic cardiomyopathy at rest and under exercise
Matthias Mueller-Hennessen, Johanna Sigl, Jens C. Fuhrmann, Henning Witt, Regina Reszka, Oliver Schmitz, Jürgen Kastler, Jenny J. Fischer, Oliver J. Müller, Evangelos Giannitsis, Tanja Weis, Norbert Frey and Hugo A. Katus

Immunosuppressive treatment in fulminant myocarditis and gene expression pattern associated with, but no histological confirmation of giant cell myocarditis
Friedrich Fruhwald, Dirk Lassner, Sonja Fruhwald, Ulrich M. Gross, Otto Dapunt and Heinz-Peter Schultheiss

Sexual function of patients with heart failure: facts and numbers
Tiny Jaarsma

Worse prognosis of real-world patients with acute heart failure from the Czech AHEAD registry in comparison to patients from the RELAX-AHF trial
Jindrich Spinar, Jiri Jarkovsky, Lenka Spinarova, Jiri Vitovec, Ales Linhart, Petr Widimsky, Roman Miklik, Kamil Zeman, Jan Belohlavek, Filip Malek, Cestmir Cihalik, Jiri Spac, Marian Felsoci, Petr Ostadal, Ladislav Dusek, Jiri Kettner, Jan Vaclavik, Simona Littnerova, Zdeněk Monhart, Josef Malek, Jiri Parenica and on behalf of the AHEAD registry investigators


Top Cited

Top Cited Papers 2015-16

2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure
Piotr Ponikowski, Adriaan A. Voors, Stefan D. Anker, Héctor Bueno, John G. F. Cleland, Andrew J. S. Coats, Volkmar Falk, José Ramón González-Juanatey, Veli-Pekka Harjola, Ewa A. Jankowska, Mariell Jessup, Cecilia Linde, Petros Nihoyannopoulos, John T. Parissis, Burkert Pieske, Jillian P. Riley, Giuseppe M. C. Rosano, Luis M. Ruilope, Frank Ruschitzka, Frans H. Rutten, Peter van der Meer, Authors/Task Force Members and Document Reviewers

Recommendations on pre-hospital & early hospital management of acute heart failure: a consensus paper from the Heart Failure Association of the European Society of Cardiology, the European Society of Emergency Medicine and the Society of Academic Emergency Medicine
Alexandre Mebazaa, M. Birhan Yilmaz, Phillip Levy, Piotr Ponikowski, W. Frank Peacock, Said Laribi, Arsen D. Ristic, Ekaterini Lambrinou, Josep Masip, Jillian P. Riley, Theresa McDonagh, Christian Mueller, Christopher deFilippi, Veli-Pekka Harjola, Holger Thiele, Massimo F. Piepoli, Marco Metra, Aldo Maggioni, John McMurray, Kenneth Dickstein, Kevin Damman, Petar M. Seferovic, Frank Ruschitzka, Adelino F. Leite-Moreira, Abdelouahab Bellou, Stefan D. Anker and Gerasimos Filippatos

Current state of knowledge on Takotsubo syndrome: a Position Statement from the Taskforce on Takotsubo Syndrome of the Heart Failure Association of the European Society of Cardiology
Alexander R. Lyon, Eduardo Bossone, Birke Schneider, Udo Sechtem, Rodolfo Citro, S. Richard Underwood, Mary N. Sheppard, Gemma A. Figtree, Guido Parodi, Yoshihiro J. Akashi, Frank Ruschitzka, Gerasimos Filippatos, Alexandre Mebazaa and Elmir Omerovic

Rationale and design of MinerAlocorticoid Receptor antagonist Tolerability Study-Heart Failure (ARTS-HF): a randomized study of finerenone vs. eplerenone in patients who have worsening chronic heart failure with diabetes and/or chronic kidney disease
Bertram Pitt, Stefan D. Anker, Michael Böhm, Mihai Gheorghiade, Lars Køber, Henry Krum, Aldo P. Maggioni, Piotr Ponikowski, Adriaan A. Voors, Faiez Zannad, Christina Nowack, So-Young Kim, Alexander Pieper, Nina Kimmeskamp-Kirschbaum and Gerasimos Filippatos

MicroRNA signatures differentiate preserved from reduced ejection fraction heart failure
Chris J. Watson, Shashi K. Gupta, Eoin O'Connell, Sabrina Thum, Nadezhda Glezeva, Jasmin Fendrich, Joe Gallagher, Mark Ledwidge, Lea Grote-Levi, Kenneth McDonald and Thomas Thum

Heart failure with preserved ejection fraction: uncertainties and dilemmas
Roberto Ferrari, Michael Böhm, John G.F. Cleland, Walter J.S. Paulus, Burkert Pieske, Claudio Rapezzi and Luigi Tavazzi

Renal effects of the angiotensin receptor neprilysin inhibitor LCZ696 in patients with heart failure and preserved ejection fraction
Adriaan A. Voors, Mauro Gori, Licette C.Y. Liu, Brian Claggett, Michael R. Zile, Burkert Pieske, John J.V. McMurray, Milton Packer, Victor Shi, Martin P. Lefkowitz, Scott D. Solomon and for the PARAMOUNT Investigators

Heart failure as a general pandemic in Asia
Hiroaki Shimokawa, Masanobu Miura, Kotaro Nochioka and Yasuhiko Sakata

Clinical picture and risk prediction of short-term mortality in cardiogenic shock
Veli-Pekka Harjola, Johan Lassus, Alessandro Sionis, Lars Køber, Tuukka Tarvasmäki, Jindrich Spinar, John Parissis, Marek Banaszewski, Jose Silva-Cardoso, Valentina Carubelli, Salvatore Di Somma, Heli Tolppanen, Uwe Zeymer, Holger Thiele, Markku S Nieminen, Alexandre Mebazaa and for the CardShock study investigators and the GREAT network
Corrected by: Corrigendum to ‘Clinical picture and risk prediction of short-term mortality in cardiogenic shock’ [Eur J Heart Fail] 2015 May;17(5):501–9. doi: 10.1002/ejhf.260

Circulating microRNAs in heart failure with reduced and preserved left ventricular ejection fraction
Lee Lee Wong, Arunmozhiarasi Armugam, Sugunavathi Sepramaniam, Dwi Setyowati Karolina, Kai Ying Lim, Jia Yuen Lim, Jenny P. C. Chong, Jessica Y. X. Ng, Yei-Tsung Chen, Michelle M. Y. Chan, Zhaojin Chen, Poh Shuan D. Yeo, Tze P. Ng, Lieng H. Ling, David Sim, Kui Toh G. Leong, Hean Y. Ong, Fazlur Jaufeerally, Raymond Wong, Ping Chai, Adrian F. Low, Carolyn S. P. Lam, Kandiah Jeyaseelan and Arthur Mark Richards

Galectin-3 in patients with heart failure with preserved ejection fraction: results from the Aldo-DHF trial
Frank Edelmann, Volker Holzendorf, Rolf Wachter, Kathleen Nolte, Albrecht G. Schmidt, Elisabeth Kraigher-Krainer, André Duvinage, Ines Unkelbach, Hans-Dirk Düngen, Carsten Tschöpe, Christoph Herrmann-Lingen, Martin Halle, Gerd Hasenfuss, Götz Gelbrich, Wendy Gattis Stough and Burkert M. Pieske

State of the Art: Newer biomarkers in heart failure
Rudolf A. de Boer, Lori B. Daniels, Alan S. Maisel and James L. Januzzi Jr


Antithrombotic/Anticoagulant papers in EJHF

Does aspirin detract from the benefits of mineralocorticoid receptor antagonists in patients with heart failure and a reduced left ventricular ejection fraction? Probably!
John G.F. Cleland

Aspirin does not reduce the clinical benefits of the mineralocorticoid receptor antagonist eplerenone in patients with systolic heart failure and mild symptoms: an analysis of the EMPHASIS-HF study
Ken Lee Chin, Timothy J. Collier, Bertram Pitt, John J.V. McMurray, Karl Swedberg, Dirk J. van Veldhuisen, Stuart J. Pocock, John Vincent, Eva Turgonyi, Faiez Zannad, Henry Krum and for the EMPHASIS-HF Study Investigators

Stroke prevention in heart failure and sinus rhythm: where do we go from here?
Muthiah Vaduganathan, Ravi B. Patel and Clyde W. Yancy

CHA2DS2-VASc score and adverse outcomes in patients with heart failure with reduced ejection fraction and sinus rhythm
Siqin Ye, Min Qian, Bo Zhao, Richard Buchsbaum, Ralph L. Sacco, Bruce Levin, Marco R. Di Tullio, Douglas L. Mann, Patrick M. Pullicino, Ronald S. Freudenberger, John R. Teerlink, J.P. Mohr, Susan Graham, Arthur J. Labovitz, Conrado J. Estol, Dirk J. Lok, Piotr Ponikowski, Stefan D. Anker, Gregory Y.H. Lip, John L.P. Thompson, Shunichi Homma and on behalf of the WARCEF Investigators

Use of non-vitamin K antagonist oral anticoagulants in patients with heart failure and atrial fibrillation: does concomitant kidney disease change our practice?
Farhan Shahid, Eduard Shantsila and Gregory Y.H. Lip

Severity of renal impairment in patients with heart failure and atrial fibrillation: implications for non-vitamin K antagonist oral anticoagulant dose adjustment
Nathaniel M. Hawkins, Pardeep S. Jhund, Andrea Pozzi, Eileen O'Meara, Scott D. Solomon, Christopher B. Granger, Salim Yusuf, Marc A. Pfeffer, Karl Swedberg, Mark C. Petrie, Sean Virani and John J.V. McMurray

Efficacy and safety of edoxaban compared with warfarin in patients with atrial fibrillation and heart failure: insights from ENGAGE AF-TIMI 48
Giulia Magnani, Robert P. Giugliano, Christian T. Ruff, Sabina A. Murphy, Francesco Nordio, Marco Metra, Tiziano Moccetti, Veselin Mitrovic, Minggao Shi, Michele Mercuri, Elliott M. Antman and Eugene Braunwald

Non-vitamin K antagonist oral anticoagulants (NOACs) in patients with concomitant atrial fibrillation and heart failure: a systemic review and meta-analysis of randomized trials
Qinmei Xiong, Yee Cheng Lau, Keitaro Senoo, Deirdre A. Lane, Kui Hong and Gregory Y.H. Lip

Thromboembolic risk stratification of patients hospitalized with heart failure in sinus rhythm: a nationwide cohort study
Emil Wolsk, Morten Lamberts, Morten L. Hansen, Paul Blanche, Lars Køber, Christian Torp-Pedersen, Gregory Y. H. Lip and Gunnar Gislason

Prediction of thrombo-embolic risk in patients with hypertrophic cardiomyopathy (HCM Risk-CVA)
Oliver P. Guttmann, Menelaos Pavlou, Constantinos O'Mahony, Lorenzo Monserrat, Aristides Anastasakis, Claudio Rapezzi, Elena Biagini, Juan Ramon Gimeno, Giuseppe Limongelli, Pablo Garcia-Pavia, William J. McKenna, Rumana Z. Omar, Perry M. Elliott and for the Hypertrophic Cardiomyopathy Outcomes Investigators

Disrupting Virchow's triad: can factor X inhibition reduce risk of adverse outcomes in patients with ischaemic cardiomyopathy?
Tariq Ahmad and Javed Butler

Rationale and design of a randomized, double-blind, event-driven, multicentre study comparing the efficacy and safety of oral rivaroxaban with placebo for reducing the risk of death, myocardial infarction or stroke in subjects with heart failure and significant coronary artery disease following an exacerbation of heart failure: the COMMANDER HF trial
Faiez Zannad, Barry Greenberg, John G.F. Cleland, Mihai Gheorghiade, Dirk J. van Veldhuisen, Mandeep R. Mehra, Stefan D. Anker, William M. Byra, Min Fu and Roger M. Mills

Effect of warfarin on survival in patients with concomitant left ventricular systolic dysfunction and pulmonary hypertension: a population cohort study
Andrew Goudie, Douglas Elder, Harshal Deshmukh, Benjamin R Szwejkowski, Chim C Lang and Jacob George

New oral anticoagulants in heart failure
Isabelle C. Van Gelder, Dirk J. Van Veldhuisen and Gregory Y.H. Lip


Best Imaging papers of 2015 – EJHF and ESCHF

For the HFA Congress, Luigi Paolo Badano selected the best papers in the field of HF imaging from EHJ, EJHF and ESCHF in 2015 and here we offer you free access to the papers from EJHF and ESCHF. The slides from the session can be found here: bit.ly/25Acrqt

The right heart in heart failure with preserved ejection fraction: insights from cardiac magnetic resonance imaging and invasive haemodynamics
Stefan Aschauer, Andreas A. Kammerlander, Caroline Zotter-Tufaro, Robin Ristl, Stefan Pfaffenberger, Alina Bachmann, Franz Duca, Beatrice A. Marzluf, Diana Bonderman and Julia Mascherbauer

Prognostic value of residual pulmonary congestion at discharge assessed by lung ultrasound imaging in heart failure
Stefano Coiro, Patrick Rossignol, Giuseppe Ambrosio, Erberto Carluccio1, Gianfranco Alunni, Adriano Murrone, Isabella Tritto, Faiez Zannad and Nicolas Girerd


Best Biomarkers papers of 2015 – EJHF and ESCHF

For the HFA Congress, Stephan von Haehling selected the best papers in the field of HF biomarkers from EHJ, EJHF and ESCHF in 2015 and here we offer you free access to the papers from EJHF and ESCHF. The slides from the session can be found here: bit.ly/25Acrqt

Prospective study on changes in blood variables in pregnant women at higher risk of peripartum cardiomyopathy
Takeshi Umazume, Takahiro Yamada, Satoshi Ishikawa, Takashi Yamada, Takahiro Koyama, Itsuko Furuta, Mamoru Morikawa, Satoshi Yamada and Hisanori Minakami

Which heart failure patients profit from natriuretic peptide guided therapy? A meta-analysis from individual patient data of randomized trials
Hans-Peter Brunner-La Rocca, Luc Eurlings, A. Mark Richards, James L. Januzzi, Matthias E. Pfisterer, Ulf Dahlström, Yigal M. Pinto, Patric Karlström, Hans Erntell, Rudolf Berger, Hans Persson, Christopher M. O'Connor, Deddo Moertl, Hanna K. Gaggin, Christopher M. Frampton, M. Gary Nicholls and Richard W. Troughton

Plasma kidney injury molecule-1 in heart failure: renal mechanisms and clinical outcome
Johanna E. Emmens, Jozine M. ter Maaten, Yuya Matsue, Marco Metra, Christopher M. O'Connor, Piotr Ponikowski, John R. Teerlink, Gad Cotter, Beth Davison, John G. Cleland, Michael M. Givertz, Daniel M. Bloomfield, Howard C. Dittrich, John Todd, Dirk J. van Veldhuisen, Hans L. Hillege, Kevin Damman, Peter van der Meer and Adriaan A. Voors

Detection of muscle wasting in patients with chronic heart failure using C-terminal agrin fragment: results from the Studies Investigating Co-morbidities Aggravating Heart Failure (SICA-HF)
Lisa Steinbeck, Nicole Ebner, Miroslava Valentova, Tarek Bekfani, Sebastian Elsner, Pius Dahinden, Stefan Hettwer, Nadja Scherbakov, Jörg C. Schefold, Anja Sandek, Jochen Springer, Wolfram Doehner, Stefan D. Anker and Stephan von Haehling

Prevalence and prognostic impact of frailty and its components in non-dependent elderly patients with heart failure
María T. Vidán, Vendula Blaya-Novakova, Elísabet Sánchez, Javier Ortiz, José A. Serra-Rexach and Héctor Bueno

Plasma growth hormone is a strong predictor of risk at 1 year in acute heart failure
Sanjay S. Bhandari, Hafid Narayan, Donald J.L. Jones, Toru Suzuki, Joachim Struck, Andreas Bergmann, Iain B. Squire and Leong L. Ng

Increased mortality with elevated plasma endothelin-1 in acute heart failure: an ASCEND-HF biomarker substudy
Antonio L. Perez, Justin L. Grodin, Yuping Wu, Adrian F. Hernandez, Javed Butler, Marco Metra, G. Michael Felker, Adriaan A. Voors, John J. McMurray, Paul W. Armstrong, Randall C. Starling, Christopher M. O'Connor and W. H. Wilson Tang

Plasma amino-terminal pro B-type natriuretic peptide as a predictor of late cardiovascular mortality in patients with acute lung disorders: a prospective, observational cohort study
Heikki O. Koskela, Päivi H. Salonen, Jarkko Romppanen and Juha Hartikainen

Soluble neprilysin does not correlate with outcome in heart failure with preserved ejection fraction
Georg Goliasch, Noemi Pavo, Caroline Zotter-Tufaro, Andreas Kammerlander, Franz Duca, Julia Mascherbauer and Diana Bonderman

Changes in N-terminal pro-B-type natriuretic peptide levels and outcomes in heart failure with preserved ejection fraction: an analysis of the I-Preserve study
Pardeep S. Jhund, Inder S. Anand, Michel Komajda, Brian L. Claggett, Robert S. McKelvie, Michael R. Zile, Peter E. Carson and John J.V. McMurray

Galectin-3 in patients with heart failure with preserved ejection fraction: results from the Aldo-DHF trial
Frank Edelmann, Volker Holzendorf, Rolf Wachter, Kathleen Nolte, Albrecht G. Schmidt, Elisabeth Kraigher-Krainer, André Duvinage, Ines Unkelbach, Hans-Dirk Düngen, Carsten Tschöpe, Christoph Herrmann-Lingen, Martin Halle, Gerd Hasenfuss, Götz Gelbrich, Wendy Gattis Stough and Burkert M. Pieske


Best Medical Therapy papers of 2015 – EJHF and ESCHF

For the HFA Congress, Adriaan Voors selected the best papers in the field of HF medical therapy from EHJ, EJHF and ESCHF in 2015 and here we offer you free access to the papers from EJHF and ESCHF. The slides from the session can be found here: bit.ly/25Acrqt

Maintenance of serum potassium with sodium zirconium cyclosilicate (ZS-9) in heart failure patients: results from a phase 3 randomized, double-blind, placebo-controlled trial
Stefan D. Anker, Mikhail Kosiborod, Faiez Zannad, Ileana L. Piña, Peter A. McCullough, Gerasimos Filippatos, Peter van der Meer, Piotr Ponikowski, Henrik S. Rasmussen, Philip T. Lavin, Bhupinder Singh, Alex Yang and Prakash Deedwania

Effect of patiromer on reducing serum potassium and preventing recurrent hyperkalaemia in patients with heart failure and chronic kidney disease on RAAS inhibitors
Bertram Pitt, George L. Bakris, David A. Bushinsky, Dahlia Garza, Martha R. Mayo, Yuri Stasiv, Heidi Christ-Schmidt, Lance Berman and Matthew R. Weir

Increased risk of stroke with darbepoetin alfa in anaemic heart failure patients with diabetes and chronic kidney disease
Natalie A. Bello, Eldrin F. Lewis, Akshay S. Desai, Inder S. Anand, Henry Krum, John J.V. McMurray, Kurt Olson, Scott D. Solomon, Karl Swedberg, Dirk J. van Veldhuisen, James B. Young and Marc A. Pfeffer

Renal effects of the angiotensin receptor neprilysin inhibitor LCZ696 in patients with heart failure and preserved ejection fraction
Adriaan A. Voors, Mauro Gori, Licette C.Y. Liu, Brian Claggett, Michael R. Zile, Burkert Pieske, John J.V. McMurray, Milton Packer, Victor Shi, Martin P. Lefkowitz, Scott D. Solomon and for the PARAMOUNT Investigators


Best Devices papers of 2015 – EJHF and ESCHF

For the HFA Congress, Kenneth Dickstein selected the best papers in the field of HF devices from EHJ, EJHF and ESCHF in 2015 and here we offer you free access to the papers from EJHF and ESCHF. The slides from the session can be found here: bit.ly/25Acrqt

Cardiac resynchronization therapy in heart failure patients with less severe left ventricular dysfunction
Ofek Y. Hai, Robert J. Mentz, Faiez Zannad, Maurizio Gasparini, Gaetano M. De Ferrari, Jean-Claude Daubert, Johannes Holzmeister, Carolyn S.P. Lam, Thierry Pochet, Alphons Vincent and Cecilia Linde

Early intervention and long-term outcome with cardiac resynchronization therapy in patients without a history of advanced heart failure symptoms
Romana Herscovici, Valentina Kutyifa, Alon Barsheshet, Scott Solomon, Scott McNitt, Bronislava Polonsky, Andy Y. Lee, Wojciech Zareba, Arthur J. Moss and Ilan Goldenberg

Cardiac resynchronization therapy in mild heart failure should be reserved for true dyssynchronopathy
Alexander H. Maass and B. Daan Westenbrink

Cardiac resynchronization revisited: what is the next step?
Cecilia Linde

Predicting outcomes following CRT: the quest continues
Camilla Normand and Kenneth Dickstein

Validation of a simple risk stratification tool for patients implanted with Cardiac Resynchronization Therapy: the VALID-CRT risk score
Maurizio Gasparini, Catherine Klersy, Cristophe Leclercq, Maurizio Lunati, Maurizio Landolina, Angelo Auricchio, Massimo Santini, Giuseppe Boriani, Alessandro Proclemer and Francisco Leyva

Reduced risk of life-threatening ventricular tachyarrhythmias with cardiac resynchronization therapy: relationship to left ventricular ejection fraction
Valentina Kutyifa, Arthur J. Moss, Scott D. Solomon, Scott McNitt, Mehmet K. Aktas, Alon Barsheshet, Bela Merkely, Wojciech Zareba and Ilan Goldenberg


In Memoriam: Henry Krum

Henry Krum left us in the last days of November 2015. Throughout his life, he made major contributions to science and, namely, to the understanding and treatment of heart failure. One demonstration of this is the remarkable number of articles published in our journal, the European Journal of Heart Failure. This virtual issue is a selection from the articles that he authored that were published in our journal; they allow us to retrace some of the major steps in our knowledge about heart failure. Scientific contributions allow investigators to survive their material life through the persistent legacy of their work, and it is my wish that this will be a small proof of how much Henry left to us.
Marco Metra, Editor-in-Chief - European Journal of Heart Failure

Increased risk of stroke with darbepoetin alfa in anaemic heart failure patients with diabetes and chronic kidney disease
Natalie A. Bello, Eldrin F. Lewis, Akshay S. Desai, Inder S. Anand , Henry Krum, John J.V. McMurray, Kurt Olson, Scott D. Solomon, Karl Swedberg, Dirk J. van Veldhuisen, James B. Young and Marc A. Pfeffer

Incidence of heart failure in 6083 elderly hypertensive patients: the Second Australian National Blood Pressure Study (ANBP2)
Berhe W. Sahle, Alice J. Owen, Henry Krum, Christopher M. Reid and on behalf of the Second Australian National Blood Pressure Study Management Committee

The Aliskiren Trial to Minimize OutcomeS in Patients with HEart failure trial (ATMOSPHERE): revised statistical analysis plan and baseline characteristics
Henry Krum, John J.V. McMurray, William T. Abraham, Kenneth Dickstein, Lars Køber, Akshay S. Desai, Scott D. Solomon, Yanntong Chiang, Claudio Gimpelewicz, Bernard Reimund, M. Atif Ali, Georgia Tarnesby, Barry M. Massie and on behalf of the ATMOSPHERE Committees and Investigators

Clinical outcomes according to QRS duration and morphology in the Eplerenone in Mild Patients: Hospitalization and SurvIval Study in Heart Failure (EMPHASIS-HF)
Jane A. Cannon, Timothy J. Collier, Li Shen, Karl Swedberg, Henry Krum, Dirk J. Van Veldhuisen, John Vincent, Stuart J. Pocock, Bertram Pitt, Faiez Zannad and John J.V. McMurray

Rationale and design of MinerAlocorticoid Receptor antagonist Tolerability Study-Heart Failure (ARTS-HF): a randomized study of finerenone vs. eplerenone in patients who have worsening chronic heart failure with diabetes and/or chronic kidney disease
Bertram Pitt, Stefan D. Anker, Michael Böhm, Mihai Gheorghiade, Lars Køber, Henry Krum, Aldo P. Maggioni, Piotr Ponikowski, Adriaan A. Voors, Faiez Zannad, Christina Nowack, So

Worsening heart failure, a critical event during hospital admission for acute heart failure: results from the VERITAS study
Gad Cotter, Marco Metra, Beth A. Davison, Stefanie Senger, Robert C. Bourge, John G.F. Cleland , Guillaume Jondeau, Henry Krum, Christopher M. O'Connor, John D. Parker, Guillermo Torre

Heart failure and dipeptidyl peptidase-4 inhibitors
Henry Krum, Marina Skiba, Shiying Wu and Ingrid Hopper

Worsening renal function during renin–angiotensin–aldosterone system inhibitor initiation and long-term outcomes in patients with left ventricular systolic dysfunction
Hannah Clark, Henry Krum and Ingrid Hopper

Interaction between baseline and early worsening of renal function and efficacy of renin–angiotensin–aldosterone system blockade in patients with heart failure: insights from the Val-HeFT study
Anastasia Lesogor, Jay N. Cohn, Roberto Latini, Gianni Tognoni, Henry Krum, Barry Massie, Andrew Zalewski, Albert Kand ra, Tsushung A. Hua and Claudio Gimpelewicz

Losing ALTITUDE? How should ASTRONAUT launch into ATMOSPHERE
Henry Krum, Barrie Massie, William T. Abraham, Kenneth Dickstein, Lars Kober, John J.V. McMurray and on behalf of the ATMOSPHERE Investigators

N-terminal B-type natriuretic peptide and the association with left ventricular diastolic function in a population at high risk of incident heart failure: results of the SCReening Evaluation of the Evolution of New-Heart Failure Study (SCREEN-HF)
Michele McGrady, Christopher M. Reid, Louise Shiel, Rory Wolfe, Umberto Boffa, Danny Liew, Duncan J. Campbell, David Prior and Henry Krum

Updated meta-analysis on antithrombotic therapy in patients with heart failure and sinus rhythm
Ingrid Hopper, Marina Skiba and Henry Krum

Impact of heart failure and changes to volume status on liver stiffness: non-invasive assessment using transient elastography
Ingrid Hopper, William Kemp, Pornwalee Porapakkham, Yusuke Sata, Eilis Condon, Marina Skiba, Lauren Farber, Pramote Porapakkham, Trevor J. Williams, Solomon Menahem, Stuart Roberts and Henry Krum

FT011, a new anti-fibrotic drug, attenuates fibrosis and chronic heart failure in experimental diabetic cardiomyopathy
Yuan Zhang, Amand a J. Edgley, Alison J. Cox, Andrew K. Powell, Bing Wang, Andrew R. Kompa, David I. Stapleton, Steven C. Zammit, Spencer J. Williams, Henry Krum, Richard E. Gilbert and Darren J. Kelly

Aliskiren, ALTITUDE, and the implications for ATMOSPHERE
John J.V. McMurray, William T. Abraham, Kenneth Dickstein, Lars Køber, Barry M. Massie and Henry Krum

Short- and long-term outcomes of intracoronary and endogenously mobilized bone marrow stem cells in the treatment of ST-segment elevation myocardial infarction: a meta-analysis of randomized control trials
Hendrik Zimmet, Pramote Porapakkham, Pornwalee Porapakkham, Yusuke Sata, Steven Joseph Haas, Silviu Itescu, Andrew Forbes and Henry Krum

Impact of concomitant heart failure on outcomes in patients undergoing percutaneous coronary interventions: analysis of the Melbourne Interventional Group registry
Ken J. Lu, Bryan P. Yan, Andrew E. Ajani, William M. Wilson, Stephen J. Duffy, Ronen Gurvitch, David J. Clark, Angela Brennan, Christopher Reid, Nick Andrianopoulos, Henry Krum and on behalf of the Melbourne Interventional Group

Short- and long-term treatment of dilutional hyponatraemia with satavaptan, a selective arginine vasopressin V2-receptor antagonist: the DILIPO study
Doron Aronson, Joseph G. Verbalis, Matthias Mueller, Henry Krum and on behalf of the DILIPO investigators

Direct renin inhibition in addition to or as an alternative to angiotensin converting enzyme inhibition in patients with chronic systolic heart failure: rationale and design of the Aliskiren Trial to Minimize OutcomeS in Patients with HEart failuRE (ATMOSPHERE) study
Henry Krum, Barry Massie, William T. Abraham, Kenneth Dickstein, Lars Kober, John J.V. McMurray, Ashkay Desai, Claudio Gimpelewicz, Albert Kand ra, Bernard Reimund, Henning Rattunde, Juergen Armbrecht and on behalf of the ATMOSPHERE Investigators

Baseline factors associated with congestive heart failure in patients receiving etoricoxib or diclofenac: multivariate analysis of the MEDAL program
Henry Krum, Sean P. Curtis, Amarjot Kaur, Hongwei Wang, Steven S. Smugar, Matthew R. Weir, Loren Laine, D. Craig Brater and Christopher P. Cannon

Adherence, adaptation and acceptance of elderly chronic heart failure patients to receiving healthcare via telephone-monitoring
Robyn A. Clark, Julie J. Yallop, Leon Piterman, Joanne Croucher, Andrew Tonkin, Simon Stewart, Henry Krum and CHAT Study Team

Tolerability of beta-blockers in elderly patients with chronic heart failure: The COLA II study
Henry Krum, Julie Hill, Friedrich Fruhwald, Christine Sharpe, Gyorgy Abraham, Jun

Practical recommendations for the use of ACE inhibitors, beta-blockers, aldosterone antagonists and angiotensin receptor blockers in heart failure: Putting guidelines into practice
John McMurray, Alain Cohen

Effect of valsartan added to background ACE inhibitor therapy in patients with heart failure: results from Val-HeFT
Henry Krum, Peter Carson, Csaba Farsang, Aldo P. Maggioni, Robert D. Glazer, Nora Aknay, Yann

NT-proBNP in severe chronic heart failure: rationale, design and preliminary results of the COPERNICUS NT-proBNP substudy
Franz Hartmann, Milton Packer, Andrew J.S. Coats, Michael B. Fowler, Henry Krum, Paul Mohacsi, Jean L. Rouleau, Michal Tendera, Alain Castaigne, Jürgen Trawinski, Ildiko Amann

Pharmacoeconomics of beta-blockers: effective and cost-effective therapy in chronic heart failure
Krum Henry and Lim Stephen


Heart Failure with Preserved Ejection Fraction (HFpEF)

Introduction

Heart failure with preserved ejection fraction (HFpEF) accounts for up to half of contemporary diagnoses of heart failure and is associated with similar adverse short- and long-term outcomes to heart failure with reduced ejection fraction (HFrEF). Notwithstanding, its diagnosis is still partially unsettled and no specific treatment has been shown as effective, yet. HFpEF has therefore drawn the attention of many outstanding researchers. This virtual issue collects and highlights some of the most recent articles published in this field by our journal.

1. Underlying biology/pathophysiology

Heart failure with preserved ejection fraction induces molecular, mitochondrial, histological, and functional alterations in rat respiratory and limb skeletal muscle
Bowen, T. Scott; Rolim, Natale P. L.; Fischer, Tina; Baekkerud, Fredrik H.; Medeiros, Alessandra; Werner, Sarah; Bronstad, Eivind; Rognmo, Oivind; Mangner, Norman; Linke, Axel; Schuler, Gerhard; Silva, Gustavo J. J.; Wisloff, Ulrik; Adams, Volker

Sex-specific cardiovascular structure and function in heart failure with preserved ejection fraction
Gori, Mauro; Lam, Carolyn S. P.; Gupta, Deepak K.; Santos, Angela B. S.; Cheng, Susan; Shah, Amil M.; Claggett, Brian; Zile, Michael R.; Kraigher-Krainer, Elisabeth; Pieske, Burkert; Voors, Adriaan A.; Packer, Milton; Bransford, Toni; Lefkowitz, Martin; McMurray, John J. V.; Solomon, Scott D.

Changes of ventricular and peripheral performance in patients with heart failure and normal ejection fraction: insights from ergometry stress echocardiography
Wang, Jing; Fang, Fang; Yip, Gabriel Wai-Kwok; Sanderson, John E.; Lee, Pui-Wai; Feng, Wei; Xie, Jun-Min; Luo, Xiu-Xia; Lam, Yat-Yin

Impaired left atrial function in heart failure with preserved ejection fraction
Santos, Angela B. S.; Kraigher-Krainer, Elisabeth; Gupta, Deepak K.; Claggett, Brian; Zile, Michael R.; Pieske, Burkert; Voors, Adriaan A.; Lefkowitz, Marty; Bransford, Toni; Shi, Victor; Packer, Milton; McMurray, John J. V.; Shah, Amil M.; Solomon, Scott D.

Insulin resistance in heart failure: differences between patients with reduced and preserved left ventricular ejection fraction
Nadja Scherbakov, Maximiliane Bauer, Anja Sandek, Tibor Szabó, Agnieszka Töpper, Ewa A. Jankowska, Jochen Springer, Stephan von Haehling, Stefan D. Anker, Mitja Lainscak, Stefan Engeli, Hans-Dirk Düngen and Wolfram Doehner

2. Diagnosis/distinguishing HFpEF from HFrEF

The middle child in heart failure: heart failure with mid-range ejection fraction (40–50%)
Carolyn S.P. Lam, and Scott D. Solomon

3. Biomarkers

HFpEF vs. HFrEF: can microRNAs advance the diagnosis?
Daniela Schmitter, Adriaan A. Voors, and Pim van der Harst

Circulating microRNAs in heart failure with reduced and preserved left ventricular ejection fraction
Wong, Lee Lee; Armugam, Arunmozhiarasi; Sepramaniam, Sugunavathi; Karolina, Dwi Setyowati; Lim, Kai Ying; Lim, Jia Yuen; Chong, Jenny P. C.; Ng, Jessica Y. X.; Chen, Yei-Tsung; Chan, Michelle M. Y.; Chen, Zhaojin; Yeo, Poh Shuan D.; Ng, Tze P.; Ling, Lieng H.; Sim, David; Leong, Kui Toh G.; Ong, Hean Y.; Jaufeerally, Fazlur; Wong, Raymond; Chai, Ping; Low, Adrian F.; Lam, Carolyn S. P.; Jeyaseelan, Kandiah; Richards, Arthur Mark

MicroRNA signatures differentiate preserved from reduced ejection fraction heart failure
Watson, Chris J.; Gupta, Shashi K.; O'Connell, Eoin; Thum, Sabrina; Glezeva, Nadezhda; Fendrich, Jasmin; Gallagher, Joe; Ledwidge, Mark; Grote-Levi, Lea; McDonald, Kenneth; Thum, Thomas

Biomarkers of heart failure with normal ejection fraction: a systematic review
Cheng, Jin M.; Akkerhuis, K. Martijn; Battes, Linda C.; van Vark, Laura C.; Hillege, Hans L.; Paulus, Walter J.; Boersma, Eric; Kardys, Isabella

4. Exercise Testing

Exercise haemodynamics may unmask the diagnosis of diastolic dysfunction among patients with pulmonary hypertension
Maor, Elad; Grossman, Yoni; Balmor, Ronen Gingy; Segel, Michael; Fefer, Paul; Ben-Zekry, Sagit; Buber, Jonathan; DiSegni, Elio; Guetta, Victor; Ben-Dov, Issahar; Segev, Amit

Cardiac output response to exercise in relation to metabolic demand in heart failure with preserved ejection fraction
Abudiab, Muaz M.; Redfield, Margaret M.; Melenovsky, Vojtech; Olson, Thomas P.; Kass, David A.; Johnson, Bruce D.; Borlaug, Barry A.

Normal resting pulmonary artery wedge pressure: a diagnostic trap for heart failure with preserved ejection fraction
Constantijn Franssen and Walter J. Paulus

A systematic review of diastolic stress tests in heart failure with preserved ejection fraction, with proposals from the EU-FP7 MEDIA study group
Erdei, Tamas; Smiseth, Otto A.; Marino, Paolo; Fraser, Alan G.

5. Prognosis/Outcomes

How do patients with heart failure with preserved ejection fraction die?
Chan, Michelle M. Y.; Lam, Carolyn S. P.

A prediction model for sudden cardiac death in patients with heart failure and preserved ejection fraction
Adabag, Selcuk; Rector, Thomas S.; Anand, Inder S.; McMurray, John J.; Zile, Michael; Komajda, Michel; McKelvie, Robert S.; Massie, Barry; Carson, Peter E.

Association between cardiovascular vs. non-cardiovascular co-morbidities and outcomes in heart failure with preserved ejection fraction
Lund, Lars H.; Donal, Erwan; Oger, Emmanuel; Hage, Camilla; Persson, Hans; Haugen-Lofman, Ida; Ennezat, Pierre-Vladimir; Sportouch-Dukhan, Catherine; Drouet, Elodie; Daubert, Jean-Claude; Linde, Cecilia

Prognostic value of N-terminal pro C-type natriuretic peptide in heart failure patients with preserved and reduced ejection fraction
Lok, Dirk J.; Klip, IJsbrand T.; Voors, Adriaan A.; Lok, Sjoukje I.; de la Porte, Pieta W. Bruggink-Andre; Hillege, Hans L.; Jaarsma, Tiny; van Veldhuisen, Dirk J.; van der Meer, Peter

C-reactive protein predicts mortality in patients referred for coronary angiography and symptoms of heart failure with preserved ejection fraction
Koller, L.; Kleber, M.; Goliasch, G.; Sulzgruber, P.; Scharnagl, H.; Silbernagel, G.; Grammer, T.; Delgado, G.; Tomaschitz, A.; Pilz, S.; Maerz, W.; Niessner, A.

Galectin-3 in patients with heart failure with preserved ejection fraction: results from the Aldo-DHF trial
Edelmann, Frank; Holzendorf, Volker; Wachter, Rolf; Nolte, Kathleen; Schmidt, Albrecht G.; Kraigher-Krainer, Elisabeth; Duvinage, Andre; Unkelbach, Ines; Duengen, Hans-Dirk; Tschoepe, Carsten; Herrmann-Lingen, Christoph; Halle, Martin; Hasenfuss, Gerd; Gelbrich, Goetz; Stough, Wendy Gattis; Pieske, Burkert M.

6. Treatment/Clinical Trials

Galectin-3 in heart failure with preserved ejection fraction
de Boer, Rudolf A.; Edelmann, Frank; Cohen-Solal, Alain; Mamas, Mamas A.; Maisel, Alan; Pieske, Burkert

N-terminal pro brain natriuretic peptide-guided management in patients with heart failure and preserved ejection fraction: findings from the Trial of Intensified versus standard Medical therapy in Elderly patients with Congestive Heart Failure (TIME-CHF)
Maeder, Micha T.; Rickenbacher, Peter; Rickli, Hans; Abbuehl, Heidi; Gutmann, Marc; Erne, Paul; Vuilliomenet, Andre; Peter, Martin; Pfisterer, Matthias; Brunner-La Rocca, Hans-Peter

Independence of the blood pressure lowering effect and efficacy of the angiotensin receptor neprilysin inhibitor, LCZ696, in patients with heart failure with preserved ejection fraction: an analysis of the PARAMOUNT trial
Jhund, Pardeep S.; Claggett, Brian; Packer, Milton; Zile, Michael R.; Voors, Adriaan A.; Pieske, Burkert; Lefkowitz, Martin; Shi, Victor; Bransford, Toni; McMurray, John J. V.; Solomon, Scott D.

Impact of adaptive servo-ventilation on cardiovascular function and prognosis in heart failure patients with preserved left ventricular ejection fraction and sleep-disordered breathing
Yoshihisa, Akiomi; Suzuki, Satoshi; Yamaki, Takayoshi; Sugimoto, Koichi; Kunii, Hiroyuki; Nakazato, Kazuhiko; Suzuki, Hitoshi; Saitoh, Shu-ichi; Takeishi, Yasuchika

The sHunt for better breathing in heart failure with preserved ejection fraction
Barry A. Borlaug

Transcatheter treatment of heart failure with preserved or mildly reduced ejection fraction using a novel interatrial implant to lower left atrial pressure
Sondergaard, Lars; Reddy, Vivek; Kaye, David; Malek, Filip; Walton, Antony; Mates, Martin; Franzen, Olaf; Neuzil, Petr; Ihlemann, Nikolaj; Gustafsson, Finn

7. General

Heart failure with preserved ejection fraction: uncertainties and dilemmas
Roberto Ferrari, Michael Böhm, John G.F. Cleland, Walter J.S. Paulus, Burkert Pieske, Claudio Rapezzi and Luigi Tavazzi

Epidemiology and clinical course of heart failure with preserved ejection fraction
Lam, Carolyn S. P.; Donal, Erwan; Kraigher-Krainer, Elisabeth; Vasan, Ramachandran S.


HFA Heart Failure Awareness Days

The HFA’s Heart Failure Awareness Days are a Europe-wide initiative, taking place on the 8th, 9th and 10th of May. The aim is to raise awareness of the importance of recognising heart failure, getting an accurate diagnosis and receiving optimal treatment. Both European Journal of Heart Failure and ESC Heart Failure are dedicated towards advancing knowledge in the field of heart failure. In recognition of the Heart Failure Awareness days, the Editor-in-Chief of European Journal of Heart Failure, Marco Metra, and the Editor-in-Chief of ESC Heart Failure, Stefan Anker, have selected the following articles for this special virtual issue:

Organization of heart failure management in European Society of Cardiology member countries: survey of the Heart Failure Association of the European Society of Cardiology in collaboration with the Heart Failure National Societies/Working Groups
Seferovic PM, Stoerk S, Filippatos G, Mareev V, Kavoliuniene A, Ristic AD, Ponikowski P, McMurray J, Maggioni A, Ruschitzka F, van Veldhuisen DJ, Coats A, Piepoli M, McDonagh T, Riley J, Hoes A, Pieske B, Dobric M, Papp Z, Mebazaa A, Parissis J, Ben Gal T, Vinereanu D, Brito D, Altenberger J, Gatzov P, Milinkovic I, Hradec J, Trochu JN, Amir O, Moura B, Lainscak M, Comin J, Wikström G, Anker S; on behalf of the Committee of National Heart Failure Societies or Working Groups of the Heart Failure Association of the European Society of Cardiology
European Journal of Heart Failure, Volume 15, Issue 9, September 2013, pages: 947-959

EURObservational Research Programme: regional differences and 1-year follow-up results of the Heart Failure Pilot Survey (ESC-HF Pilot)
Maggioni AP, Dahlström U, Filippatos G, Chioncel O, Crespo Leiro M, Drozdz J, Fruhwald F, Gullestad L, Logeart D, Fabbri G, Urso R, Metra M, Parissis J, Persson H, Ponikowski P, Rauchhaus M, Voors AA, Nielsen OW, Zannad F, Tavazzi L; Heart Failure Association of the European Society of Cardiology (HFA)
European Journal of Heart Failure, Volume 15, Issue 7, July 2013, pages: 808-817

Current aspects of the spectrum of acute heart failure syndromes in a real-life setting: the OFICA study
Logeart D, Isnard R, Resche-Rigon M, Seronde MF, de Groote P, Jondeau G, Galinier M, Mulak G, Donal E, Delahaye F, Juilliere Y, Damy T, Jourdain P, Bauer F, Eicher JC, Neuder Y, Trochu JN; and on behalf of the working group on Heart Failure of the French Society of Cardiology European Journal of Heart Failure, Volume 15, Issue 4, April 2013, pages: 465-476

Co-morbidities in patients with heart failure: an analysis of the European Heart Failure Pilot Survey
van Deursen VM, Urso R, Laroche C, Damman K, Dahlström U, Tavazzi L, Maggioni AP, Voors AA
European Journal of Heart Failure, Volume 16, Issue 1, January 2014, pages: 103-111

Burden of new hospitalization for heart failure: a population-based investigation from Italy
Corrao G, Ghirardi A, Ibrahim B, Merlino L, Maggioni AP
European Journal of Heart Failure, Volume 16, Issue 7, July 2014, pages: 729-736

The epidemiology of heart failure, based on data for 2.1 million inhabitants in Sweden
Zarrinkoub R, Wettermark B, Wändell P, Mejhert M, Szulkin R, Ljunggren G, Kahan T
European Journal of Heart Failure, Volume 15, Issue 9, September 2013, pages: 995-1002

Heart failure: preventing disease and death worldwide
Piotr Ponikowski, Stefan D. Anker, Khalid F. AlHabib, Martin R. Cowie, Thomas L. Force, Shengshou Hu, Tiny Jaarsma, Henry Krum, Vishal Rastogi, Luis E. Rohde, Umesh C. Samal, Hiroaki Shimokawa, Bambang Budi Siswanto, Karen Sliwa and Gerasimos Filippatos
ESC Heart Failure, Volume 1, Issue 1, September 2014, pages: 4-25

Steps forward in regulatory pathways for acute and chronic heart failure
Luca Pani, Sergio Pecorelli, Giuseppe Rosano, Stefan D. Anker, Andrea Peracino, Laura Fregonese, Krishna Prasad, and Guido Rasi
ESC Heart Failure, Volume 1, Issue 2, December 2014, pages: 87-93

Ischemic stroke and heart failure: facts and numbers
Nadja Scherbakov, Karl Georg Haeusler, and Wolfram Doehner
ESC Heart Failure, Volume 2, Issue 1, March 2015, pages: 1-4

Altered myocardial force generation in end-stage human heart failure
Zoltán Papp, Jolanda van der Velden, Attila Borbély, István Édes and Ger J.M. Stienen
ESC Heart Failure, Volume 1, Issue 2, December 2014, pages: 160-165

Facts and numbers on epidemiology and pharmacological treatment of heart failure with preserved ejection fraction
Frank Edelmann
ESC Heart Failure, Volume 2, Issue 2, June 2015, pages: 41-45

Heart failure in Southeast Asia: facts and numbers
Carolyn S.P. Lam
ESC Heart Failure, Volume 2, Issue 2, June 2015, pages: 46-49


Top cited articles: Celebrating 5 years as Editor-in-Chief of EJHF
I took over as Editor-in-Chief of EJHF on 1 January 2010, and from the beginning, ‘doing’ the Journal in Groningen was a big source of inspiration and we enjoyed it enormously. I was very fortunate to be able to assign Professor Adriaan Voors and Professor Wiek van Gilst as Deputy Editors, and 15 Associate Editors from our department (14 in Cardiology and 1 in CardioThoracic Surgery) who were all dedicated to heart failure (more details are in the Editorial of the December 2014 issue of the Journal).
During our time on the Journal, we were privileged to see some excellent submissions from around the world that have driven forward our understanding of heart failure, and improved its treatment, so we are very proud to share with you now the most cited works from the 5 years of our tenure.
Dirk J. van Veldhuisen, EJHF Editor-in-Chief (2010-2014)

Co-morbidities in patients with heart failure: an analysis of the European Heart Failure Pilot Survey
Van Deursen, Vm; Urso, R; Laroche, C; Damman, K; Dahlstrom, U; Tavazzi, L; Maggioni, Ap; Voors, Aa

Baseline characteristics and treatment of patients in Prospective comparison of ARNI with ACEI to Determine Impact on Global Mortality and morbidity in Heart Failure trial (PARADIGM-HF)
Mcmurray, Jjv; Packer, M; Desai, As; Gong, Jj; Lefkowitz, M; Rizkala, Ar; Rouleau, Jl; Shi, Vc; Solomon, Sd; Swedberg, K; Zile, Mr

The Chronic Kidney Disease Epidemiology Collaboration equation outperforms the Modification of Diet in Renal Disease equation for estimating glomerular filtration rate in chronic systolic heart failure
Valente, MAE; Hillege, HL; Navis, G; Voors, AA; Dunselman, PHJM; van Veldhuisen, DJ; Damman, K

Cardiac output response to exercise in relation to metabolic demand in heart failure with preserved ejection fraction
Abudiab, MM; Redfield, MM; Melenovsky, V; Olson, TP; Kass, DA; Johnson, BD; Borlaug, BA

Effects of carvedilol on heart failure with preserved ejection fraction: the Japanese Diastolic Heart Failure Study (J-DHF)
Yamamoto, K; Origasa, H; Hori, M

EURObservational Research Programme: regional differences and 1-year follow-up results of the Heart Failure Pilot Survey (ESC-HF Pilot)
Maggioni, AP; Dahlstrom, U; Filippatos, G; Chioncel, O; Leiro, MC; Drozdz, J; Fruhwald, F; Gullestad, L; Logeart, D; Fabbri, G; Urso, R; Metra, M; Parissis, J; Persson, H; Ponikowski, P; Rauchhaus, M; Voors, AA; Nielsen, OW; Zannad, F; Tavazzi, L

Dual angiotensin receptor and neprilysin inhibition as an alternative to angiotensin-converting enzyme inhibition in patients with chronic systolic heart failure: rationale for and design of the Prospective comparison of ARNI with ACEI to Determine Impact on Global Mortality and morbidity in Heart Failure trial (PARADIGM-HF)
McMurray, JJV; Packer, M; Desai, AS; Gong, J; Lefkowitz, MP; Rizkala, AR; Rouleau, J; Shi, VC; Solomon, SD; Swedberg, K; Zile, MR

ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012 The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC
McMurray, JJV; Adamopoulos, S; Anker, SD; Auricchio, A; Bohm, M; Dickstein, K; Falk, V; Filippatos, G; Fonseca, C; Gomez-Sanchez, MA; Jaarsma, T; Kober, L; Lip, GYH; Maggioni, AP; Parkhomenko, A; Pieske, BM; Popescu, BA; Ronnevik, PK; Rutten, FH; Schwitter, J; Seferovic, P; Stepinska, J; Trindade, PT; Voors, AA; Zannad, F; Zeiher, A

MitraClip therapy in daily clinical practice: initial results from the German transcatheter mitral valve interventions (TRAMI) registry
Baldus, S; Schillinger, W; Franzen, O; Bekeredjian, R; Sievert, H; Schofer, J; Kuck, KH; Konorza, T; Mollmann, H; Hehrlein, C; Ouarrak, T; Senges, J; Meinertz, T

Serum levels of microRNAs in patients with heart failure
Goren, Y; Kushnir, M; Zafrir, B; Tabak, S; Lewis, BS; Amir, O

MitraClip (R) therapy in patients with end-stage systolic heart failure
Franzen, O; van der Heyden, J; Baldus, S; Schluter, M; Schillinger, W; Butter, C; Hoffmann, R; Corti, R; Pedrazzini, G; Swaans, MJ; Neuss, M; Rudolph, V; Surder, D; Grunenfelder, J; Eulenburg, C; Reichenspurner, H; Meinertz, T; Auricchio, A

Epidemiology and clinical course of heart failure with preserved ejection fraction
Lam, CSP; Donal, E; Kraigher-Krainer, E; Vasan, RS

Current state of knowledge on aetiology, diagnosis, management, and therapy of peripartum cardiomyopathy: a position statement from the Heart Failure Association of the European Society of Cardiology Working Group on peripartum cardiomyopathy
Sliwa, K; Hilfiker-Kleiner, D; Petrie, MC; Mebazaa, A; Pieske, B; Buchmann, E; Regitz-Zagrosek, V; Schaufelberger, M; Tavazzi, L; van Veldhuisen, DJ; Watkins, H; Shah, AJ; Seferovic, PM; Elkayam, U; Pankuweit, S; Papp, Z; Mouquet, F; McMurray, JJV

Assessing and grading congestion in acute heart failure: a scientific statement from the Acute Heart Failure Committee of the Heart Failure Association of the European Society of Cardiology and endorsed by the European Society of Intensive Care Medicine
Gheorghiade, M; Follath, F; Ponikowski, P; Barsuk, JH; Blair, JEA; Cleland , JG; Dickstein, K; Drazner, MH; Fonarow, GC; Jaarsma, T; Jondeau, G; Sendon, JL; Mebazaa, A; Metra, M; Nieminen, M; Pang, PS; Seferovic, P; Stevenson, LW; van Veldhuisen, DJ; Zannad, F; Anker, SD; Rhodes, A; McMurray, JJV; Filippatos, G

2010 Focused Update of ESC Guidelines on device therapy in heart failure
Dickstein, K; Vardas, PE; Auricchio, A; Daubert, JC; Linde, C; McMurray, J; Ponikowski, P; Priori, SG; Sutton, R; van Veldhuisen, DJ




Sleep Apnoea / Sleep-disordered Breathing and Heart Failure

Papers selected by Professor Dr Dirk J van Veldhuisen

Introduction

Sleep apnoea (or sleep-disordered breathing), and in particular central sleep apnoea (CSA), is one of the more recent additions to the list of significant co-morbidities of heart failure; it is ‘the new kid on the block’. Prevalence levels of up to 60% have been reported in studies of patients with heart failure, and CSA has also been associated with increased mortality in some studies, perhaps as much as doubling the mortality risk of patients with heart failure.

To date, no interventional study has been able to improve outcome in these patients but a few studies are currently underway, the results of which are awaited with interest. We present here a collection of articles from EJHF spanning the prognostic impact, associations with other symptoms, and treatment of sleep apnoea in heart failure patients.

Comorbidities:

Co-morbidities in patients with heart failure: an analysis of the European Heart Failure Pilot Survey
Vincent M. van Deursen, Renato Urso, Cecile Laroche, Kevin Damman, Ulf Dahlström, Luigi Tavazzi, Aldo P. Maggioni and Adriaan A. Voors European Journal of Heart Failure Volume 16, Issue 1, January 2014, pages: 103–111

Prognostic impact of sleep disordered breathing and its treatment in heart failure: an observational study
Clemens Jilek, Marion Krenn, Daniela Sebah, Ruth Obermeier, Astrid Braune, Victoria Kehl, Stephan Schroll, Sylvia Montalvan, Günter A.J. Riegger, Michael Pfeifer, and Michael Arzt
European Journal of Heart Failure Volume 13, Issue 1, January 2011, pages 68-75

Symptoms:

Central sleep apnoea and inflammation are independently associated with arrhythmia in patients with heart failure
Kan Sano, Eiichi Watanabe, Junichiro Hayano, Yuuki Mieno, Yoshihiro Sobue, Mayumi Yamamoto, Tomohide Ichikawa, Hiroki Sakakibara, Kazuyoshi Imaizumi, and Yukio Ozaki
European Journal of Heart Failure Volume 15, Issue 9, September 2013, pages 1003 – 1010

Study Designs

Rationale and design of the SERVE-HF study: treatment of sleep-disordered breathing with predominant central sleep apnoea with adaptive servo-ventilation in patients with chronic heart failure
Martin R. Cowie, Holger Woehrle, Karl Wegscheider, Christiane Angermann, Marie-Pia d'Ortho, Erland Erdmann, Patrick Levy, Anita Simonds, Virend K. Somers, Faiez Zannad, and Helmut Teschler
European Journal of Heart Failure Volume 15, Issue 8 , August 2013, pages 937 - 943

Therapy

Adaptive servo-ventilation therapy improves cardiac sympathetic nerve activity in patients with heart failure
Takashi Koyama, Hiroyuki Watanabe, Yoshikazu Tamura, Yasunori Oguma, Toshimitsu Kosaka, and Hiroshi Ito
European Journal of Heart Failure Volume 15, Issue 8, August 2013, pages 902 – 909

Article

Association between sleep-disordered breathing, sleep–wake pattern, and cognitive impairment among patients with chronic heart failure
Carina Hjelm, Anna Strömberg, Kristofer Årestedt, and Anders Broström
European Journal of Heart Failure Volume 15, Issue 5, May 2013, pages 496-504

Treatment

Impact of adaptive servo-ventilation on cardiovascular function and prognosis in heart failure patients with preserved left ventricular ejection fraction and sleep-disordered breathing
Akiomi Yoshihisa, Satoshi Suzuki, Takayoshi Yamaki, Koichi Sugimoto, Hiroyuki Kunii, Kazuhiko Nakazato, Hitoshi Suzuki, Shu-ichi Saitoh, and Yasuchika Takeishi
European Journal of Heart Failure Volume 15, Issue 5, May 2013 , pages 543-550

Comparison of acute and chronic impact of adaptive servo-ventilation on left chamber geometry and function in patients with chronic heart failure
Nobuhiko Haruki, Masaaki Takeuchi, Kyoko Kaku, Hidetoshi Yoshitani, Hiroshi Kuwaki, Masahito Tamura, Haruhiko Abe, Masahiro Okazaki, Akizumi Tsutsumi, and Yutaka Otsuji
European Journal of Heart Failure Volume 13, Issue 10, October 2011, pages 1140-1146

Impact of device-guided slow breathing on symptoms of chronic heart failure: a randomized, controlled feasibility study
Inger Ekman, Barbro Kjellström, Kristin Falk, Jonna Norman, and Karl Swedberg
European Journal of Heart Failure, Volume 1, Issue 9, September 2011, pages 1000-

Treatment of sleep-disordered breathing in heart failure: reduction of high ventricular wall stress should be a diagnostic and therapeutic target
Peter Alter and Heinz Rupp
European Journal of Heart Failure Volume 14, Issue 10, October 2013, page 1189

Prognosis:

Prognostic impact of sleep-disordered breathing and its treatment with nocturnal ventilation for chronic heart failure
Thibaud Damy, Laurent Margarit, Ala Noroc, Diane Bodez, Soulef Guendouz, Laurent Boyer, Xavier Drouot, Aurélia Lamine, Alexandra Paulino, Stéphane Rappeneau, Maria-Hermann Stoica, Jean-Luc Dubois-Randé, Serge Adnot, Luc Hittinger, and Marie Pia d'Ortho
European Journal of Heart Failure Volume 14, Issue 9, September 2012, pages 1009-1019

Editorial:

Adaptive servo-ventilation in heart failure associated with central sleep apnoea. Is it effective in both acute and chronic setting?
Joost M.A.A. van der Maaten and, Peter J. Wijkstra
European Journal of Heart Failure Volume 13, Issue 10, October, 2011, pages 1049-1051

Central sleep apnoea: another important comorbidity in heart failure?
Peter J. Wijkstra and Dirk J van Veldhuisen
European Journal of Heart Failure Volume 12, Issue 4, April 2010, pages 309-10

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