Journal of Tissue Engineering and Regenerative Medicine

Cover image for Vol. 11 Issue 9

Edited By: Rui L. Reis

Impact Factor: 3.989

ISI Journal Citation Reports © Ranking: 2016: 6/21 (CELL & TISSUE ENGINEERING); 8/77 (Engineering Biomedical); 28/158 (Biotechnology & Applied Microbiology); 70/189 (Cell Biology)

Online ISSN: 1932-7005


Journal of Tissue Engineering and Regenerative Medicine is a multidisciplinary journal that publishes research and reviews on the development of therapeutic approaches which combine stem/progenitor cells with biomaterials and scaffolds, and growth factors and other bioactive agents. The journal focuses on the development of biological functional substitutes that restore, maintain, or improve tissue or organ function.

Aims and Scope

Journal of Tissue Engineering and Regenerative Medicine publishes rapidly and rigorously peer-reviewed research papers, reviews, clinical case reports, perspectives, and short communications on topics relevant to the development of therapeutic approaches which combine stem or progenitor cells, biomaterials and scaffolds, growth factors and other bioactive agents, and their respective constructs. All papers should deal with research that has a direct or potential impact on the development of novel clinical approaches for the regeneration or repair of tissues and organs.

The journal is multidisciplinary, covering the combination of the principles of life sciences and engineering in efforts to advance medicine and clinical strategies. The journal focuses on the use of cells, materials, and biochemical/mechanical factors in the development of biological functional substitutes that restore, maintain, or improve tissue or organ function. The journal publishes research on any tissue or organ and covers all key aspects of the field, including the development of new biomaterials and processing of scaffolds; the use of different types of cells (mainly stem and progenitor cells) and their culture in specific bioreactors; studies in relevant animal models; and clinical trials in human patients performed under strict regulatory and ethical frameworks. Manuscripts describing the use of advanced methods for the characterization of engineered tissues are also of special interest to the journal readership.

Coverage Includes

Studies on the interactions between cells and constructs are welcome, particularly where they advance our understanding of these processes or provide clear suggestions for improvements to existing systems. Surface modification technologies, their effects on protein adsorption and on cell seeding adhesion and proliferation are of major interest to the journal. Both in vitro and in vivo approaches will be considered, as the journal also aims to focus on in vivo responses to cell-material constructs. Typically, papers presenting the design, development or refinement of biomaterials or scaffolds will only be considered when these have been tested for their ability to support cellular attachment/interaction and/or growth, development and differentiation.

The journal also publishes manuscripts dealing with novel approaches to regenerative medicine that apply some type of controlled/sustained release strategy. Papers dealing with the development of carrier systems, cell encapsulation, release of drugs, growth factors, differentiation agents, and other types of bioactive agents, especially when they apply nanotechnology and/or non-invasive approaches, are particularly welcome. Works on the use of tissue engineering to develop novel drug discovery/testing methodologies and models are also of special interest. A particular emphasis is also to be placed on inductive scaffolds and matrices and on smart systems, including self-assembly materials, which will react to physiological stimuli and will elicit some exact and controllable response of specific cell types.

Research on the use of different cell types and methods for controlling their isolation, expansion and differentiation, and manuscripts describing the effects of manipulating cells, such as by gene therapy, or by supplying proteins, DNA or other biomolecules within the constructs used are also encouraged. Submissions of works on the derivation and maintenance of new stem cell lines and on the development of novel cocktails and serum free media for their culturing are also invited. Manuscripts addressing fundamental issues of stem cell biology, namely those related with stem cell plasticity, potency, clonality, etc., will be considered only if there is some discussion on potential strategies for their application in relevant clinical situations, in cell based therapies or regenerative medicine approaches. Papers on cell transplantation technologies, as well as on the use of stem cells in drug discovery are welcome. Works on relevant regulatory and ethical issues might also be considered.

The journal also focuses on the use of bioreactors for cell seeding, culturing and stimulation of cell differentiation. Papers on the effects of diffusion and mechanical stimulation of stem and progenitor cells are welcome. The design of novel bioreactors, the use of bioreactors for 2D and 3D tissue growth, as well as all production and scale-up aspects related to the use of bioreactors and its effect on the clinical introduction of new technologies will be welcomed. Papers on industrial and patent aspects of tissue engineering and regenerative medicine are also within the scope of the journal.


Cell and molecular biologists, materials and biomaterials scientists, biomedical engineers, chemists, medical researchers, clinicians and surgeons specialising in chronic and degenerative diseases, on cell therapies and trauma surgery


Tissue Engineering; Regenerative Medicine; Stem Cells; Biomaterials; Scaffolds; Clinical Trials; Cell Therapy; Cell Culture; Smart Materials; Animal Models; Bioreactors; Surgery; Tissues; Organs; Progenitor Cells; Gene Therapy; In vitro; In vivo; Biodegradable; Polymers; Self-Assembly; Minimally-invasive; Surface Modification; Constructs; Transplantation; Repair; Replacement; Regeneration; Artificial Organs; Protein Adsorption

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