Interpretation of p16INK4a/Ki-67 dual immunostaining for the triage of human papillomavirus-positive women by experts and nonexperts in cervical cytology
Elena Allia, Guglielmo Ronco, Anna Coccia, Patrizia Luparia, Luigia Macrì, Corinna Fiorito, Francesca Maletta, Cristina Deambrogio, Sara Tunesi, Laura De Marco, Anna Gillio-Tos, Anna Sapino and Bruno Ghiringhello
Article first published online: 22 DEC 2014 | DOI: 10.1002/cncy.21511
In the current study, p16INK4a/Ki-67 immunostaining demonstrated good reproducibility and specificity when triaging women who were positive for the human papillomavirus. Dual-staining interpretation can be performed, after brief training, even by staff who are not experts in the morphological interpretation of cytology.