Cancer Cytopathology

Cover image for Vol. 125 Issue 2

Early View (Online Version of Record published before inclusion in an issue)

Edited By: Celeste N. Powers, MD, PhD

Impact Factor: 3.183

ISI Journal Citation Reports © Ranking: 2015: 17/79 (Pathology); 89/213 (Oncology)

Online ISSN: 1934-6638

Associated Title(s): Cancer, CA: A Cancer Journal for Clinicians

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  1. 1 - 19
  1. Original Articles

    1. Human epididymis protein 4 immunostaining of malignant ascites differentiates cancer of Müllerian origin from gastrointestinal cancer

      Anna Stiekema, Koen K. Van de Vijver, Henk Boot, Annegien Broeks, Catharina M. Korse, Willemien J. van Driel, Gemma G. Kenter and Christianne A.R. Lok

      Version of Record online: 15 FEB 2017 | DOI: 10.1002/cncy.21811

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      Human epididymis protein 4 immunostaining in ascites is feasible, and appears to have a high sensitivity for high-grade serous ovarian cancer. Human epididymis protein 4 can be a useful addition to the current panel of immunocytochemistry markers for the diagnosis of epithelial ovarian cancer and for differentiation with gastrointestinal adenocarcinomas.

  2. Review Articles

    1. Diagnosis of anaplastic lymphoma kinase rearrangement in cytological samples through a fluorescence in situ hybridization–based assay: Cytological smears versus cell blocks

      Federica Zito Marino, Giulio Rossi, Matteo Brunelli, Maria Gabriella Malzone, Giuseppina Liguori, Giuseppe Bogina, Alessandro Morabito, Gaetano Rocco, Renato Franco and Gerardo Botti

      Version of Record online: 14 FEB 2017 | DOI: 10.1002/cncy.21835

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      The adequacy of lung cytological samples is a hot issue for anaplastic lymphoma kinase fluorescence in situ hybridization assays. The optimal triage of lung cytological samples is mandatory.

  3. Original Articles

    1. Cytological, molecular, and clinical features of noninvasive follicular thyroid neoplasm with papillary-like nuclear features versus invasive forms of follicular variant of papillary thyroid carcinoma

      Liena Zhao, Dora Dias-Santagata, Peter M. Sadow and William C. Faquin

      Version of Record online: 13 FEB 2017 | DOI: 10.1002/cncy.21839

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      Despite significant differences in the cytological classification and molecular profiles of noninvasive follicular thyroid neoplasm with papillary-like nuclear features and the invasive follicular variant of papillary thyroid carcinoma, the degree of overlap makes it unlikely that most cases can be accurately distinguished by fine-needle aspiration biopsy.

    2. Thyroid cytology—nuclear versus architectural atypia within the “Atypia of undetermined significance/follicular lesion of undetermined significance” Bethesda category have significantly different rates of malignancy

      Tiffany Rui Xuan Gan, Min En Nga, Jeffrey Huey Yew Lum, Wendy Meihua Wong, Wee Boon Tan, Rajeev Parameswaran and Kee Yuan Ngiam

      Version of Record online: 13 FEB 2017 | DOI: 10.1002/cncy.21823

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      In this Singapore cohort, the malignancy rate for surgically excised thyroid nodules with a diagnosis of atypia of undetermined significance/follicular lesion of undetermined significance is 27%, and the presence of nuclear atypia yields a significantly higher malignancy rate at 36.8% than architectural atypia at 14.7%. Subclassification of the “atypical” Bethesda category should be advocated.

  4. Correspondence

  5. Original Articles

    1. Challenge of FNA diagnosis of angiomyolipoma: A study of 33 cases

      Haijun Zhou, Ming Guo and Yun Gong

      Version of Record online: 2 FEB 2017 | DOI: 10.1002/cncy.21824

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      Fine-needle aspiration diagnosis of angiomyolipoma may be challenging, especially with an extrarenal location and/or with a predominantly epithelioid component. Immunostaining may help diagnostic accuracy.

    2. You have full text access to this OnlineOpen article
      Qualifiers of atypia in the cytologic diagnosis of thyroid nodules are associated with different Afirma gene expression classifier results and clinical outcomes

      Sylvan C. Baca, Kristine S. Wong, Kyle C. Strickland, Howard T. Heller, Matthew I. Kim, Justine A. Barletta, Edmund S. Cibas, Jeffrey F. Krane, Ellen Marqusee and Trevor E. Angell

      Version of Record online: 2 FEB 2017 | DOI: 10.1002/cncy.21827

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      Thyroid nodules with atypia of undetermined significance cytology and Afirma gene expression classifier (GEC) testing are analyzed based on the presence of architectural, cytologic, or both cytologic and architectural atypia. Nodules with architectural atypia are the most likely to have a benign GEC result and least likely to be malignant, suggesting that clinicians should be aware of these cytologic qualifiers when advising patients regarding GEC testing and the risk of malignancy.

    3. Metabonomics by proton nuclear magnetic resonance in human pleural effusions: A route to discriminate between benign and malignant pleural effusions and to target small molecules as potential cancer biomarkers

      Lucio Zennaro, Paola Vanzani, Lorenzo Nicolè, Rocco Cappellesso and Ambrogio Fassina

      Version of Record online: 31 JAN 2017 | DOI: 10.1002/cncy.21832

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      Proton nuclear magnetic resonance metabonomic profiling is a valid tool for discriminating between benign and malignant effusions.

    4. Improvements in cell block processing: The Cell-Gel method

      Kristin A. La Fortune, Melissa L. Randolph, Howard H. Wu and Harvey M. Cramer

      Version of Record online: 31 JAN 2017 | DOI: 10.1002/cncy.21814

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      Cell blocks are routinely processed from fine-needle aspiration specimens or concentrated fluid samples. The authors have developed an effective and inexpensive process for producing cell blocks that consistently yields abundant cellular material.

    5. Cytology assessment can predict survival for patients with metastatic pancreatic neuroendocrine neoplasms

      Carlie S. Sigel, Huimin Guo, Keith M. Sigel, Ming Zhang, Natasha Rekhtman, Oscar Lin, David S. Klimstra, Achim A. Jungbluth and Laura K. Tang

      Version of Record online: 17 JAN 2017 | DOI: 10.1002/cncy.21817

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      Grading metastatic pancreatic neuroendocrine neoplasms to the liver using the Ki-67 index on cytology may not correlate exactly with concurrent core needle biopsy specimens, but differentiation and grade as determined on cytology specimens are predictive of patient survival.

    6. Next-generation sequencing of liquid-based cytology non–small cell lung cancer samples

      Jordan P. Reynolds, Yaolin Zhou, Maureen A. Jakubowski, Zhen Wang, Jennifer A. Brainard, Roger D. Klein, Carol F. Farver, Francisco A. Almeida and Yu-Wei Cheng

      Version of Record online: 13 JAN 2017 | DOI: 10.1002/cncy.21812

      Non–small cell lung cancer mutation analysis using next-generation sequencing may be successfully performed on residual cell pellets derived from liquid-based cytology samples.

    7. Filter paper-assisted cell transfer (FaCT) technique: A novel cell-sampling technique for intraoperative diagnosis of central nervous system tumors

      Jumpei Kawamura, Shingo Kamoshida, Takaaki Shimakata, Yurie Hayashi, Kuniko Sakamaki, Tamami Denda, Kenji Kawai and Sadahito Kuwao

      Version of Record online: 5 JAN 2017 | DOI: 10.1002/cncy.21816

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      The authors establish the filter paper-assisted cell transfer (FaCT) smear technique, in which tumor cells are transferred onto a glass slide directly from the filter paper sample spot after the biopsy is removed. The FaCT smear technique is a simple and effective processing method with significant value for intraoperative diagnosis of central nervous system tumors.

    8. Interobserver reproducibility of cytologic p16INK4a/Ki-67 dual immunostaining in human papillomavirus-positive women

      Maria Benevolo, Elena Allia, Daniela Gustinucci, Francesca Rollo, Simonetta Bulletti, Elena Cesarini, Basilio Passamonti, Maria Rosaria Giovagnoli, Elisabetta Carico, Francesca M. Carozzi, Alessandra Mongia, Giulia Fantacci, Massimo Confortini, Teresa Rubino, Cristina Fodero, Sonia Prandi, Natalina Marchi, Angelo Farruggio, Anna Coccia, Luigia Macrì, Bruno Ghiringhello, Guglielmo Ronco, Emma Bragantini, Enzo Polla, Vincenzo Maccallini, Giovanni Negri, Paolo Giorgi Rossi and for the New Technologies for Cervical Cancer Screening 2 (NTCC2) Working Group

      Version of Record online: 7 DEC 2016 | DOI: 10.1002/cncy.21800

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      In human papillomavirus (HPV)-based cervical cancer screening, dual-staining for cyclin-dependent kinase inhibitor 2A (p16ink4a) and Ki-67 has been proposed as a biomarker for triaging women who are positive for HPV DNA. Staining for p16ink4a/Ki-67 has good reproducibility between readers from 9 different laboratories, confirming its robustness, which is a necessary requisite for its introduction into cervical cancer screening.

    9. Preoperative characteristics and cytological features of 136 histologically confirmed pancreatic mucinous cystic neoplasms

      Aristana Scourtas, Jonathan C. Dudley, William R. Brugge, Abdurrahman Kadayifci, Mari Mino-Kenudson and Martha B. Pitman

      Version of Record online: 7 DEC 2016 | DOI: 10.1002/cncy.21806

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      Cytology is insensitive but very specific for the detection of high-risk mucinous cystic neoplasms (MCNs) of the pancreas. In the current study, cytology outperformed imaging for the detection of high-risk MCN. Endoscopic ultrasound-guided fine-needle aspiration and cytology should be performed on any patient with clinically suspected MCN who is being considered for conservative management.

  6. Review Articles

    1. Big data from small samples: Informatics of next-generation sequencing in cytopathology

      Sinchita Roy-Chowdhuri, Somak Roy, Sara E. Monaco, Mark J. Routbort and Liron Pantanowitz

      Version of Record online: 5 DEC 2016 | DOI: 10.1002/cncy.21805

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      The increasing use of next-generation sequencing in clinical laboratories has redefined the practice of cytopathology with an emphasis on maximizing small samples for highly multiplexed assays. Understanding the computational components and adapting to the informatics challenges of next-generation sequencing–based testing are crucial for the optimal utilization of cytology specimens.

  7. Original Articles

    1. Clinical value of fully automated p16/Ki-67 dual staining in the triage of HPV-positive women in the Norwegian Cervical Cancer Screening Program

      Irene T. Ovestad, Ingvild Dalen, Elisabeth Hansen, Janne L.D. Loge, Britt Mona Dybdahl, Marius B. Dirdal, Pia Moltu and Jannicke M. Berland

      Version of Record online: 5 DEC 2016 | DOI: 10.1002/cncy.21807

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      In a secondary screening population, p16/Ki-67 dual staining has shown high clinical sensitivity for the triaging of human papillomavirus–positive women. Combination testing with both cytology and p16/Ki-67 dual staining has the potential to more accurately detect women who immediately need to be referred for colposcopy and biopsy.

  8. Commentary

    1. Cytological reporting on lung FNA and small biopsy specimens in the era of personalized medicine

      Mari Mino-Kenudson

      Version of Record online: 2 NOV 2016 | DOI: 10.1002/cncy.21793

      Because of the advancement of personalized medicine in lung cancer, the subtyping of non–small cell lung cancer and predictive biomarker testing with fine-needle aspiration and biopsy specimens have never been more important. The pathologist needs to efficiently handle these small specimens, report the diagnosis/subtype in a clinically relevant format, and evaluate the tissue adequacy for molecular testing.

  9. Original Articles

    1. Significance of high-risk HPV detection in women with atypical glandular cells on Pap testing: Analysis of 1857 cases from an academic institution

      Stell Patadji, Zaibo Li, Dinesh Pradhan and Chengquan Zhao

      Version of Record online: 24 OCT 2016 | DOI: 10.1002/cncy.21791

      In the current study, the authors present the results of a retrospective search of their pathology database for cases of atypical glandular cells with concurrent high-risk human papillomavirus testing and histological follow-up results within 1 year. The results indicate that the human papillomavirus test can be useful in predicting the risk of high-grade cervical lesions for women with atypical glandular cells.

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