Cancer Cytopathology

Cover image for Vol. 122 Issue 12

Early View (Online Version of Record published before inclusion in an issue)

Edited By: Celeste N. Powers, MD, PhD

Impact Factor: 3.807

ISI Journal Citation Reports © Ranking: 2013: 15/76 (Pathology); 58/203 (Oncology)

Online ISSN: 1934-6638

Associated Title(s): Cancer, CA: A Cancer Journal for Clinicians


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  1. Review Articles

    1. Biospecimen repositories and cytopathology

      Savitri Krishnamurthy

      Article first published online: 18 DEC 2014 | DOI: 10.1002/cncy.21505

      The potential for biobanking of cytopathology specimen is excellent. Further studies are needed to establish definite protocols for biobanking of thes specimens

  2. Original Articles

    1. Verification and classification bias interactions in diagnostic test accuracy studies for fine-needle aspiration biopsy

      Robert L. Schmidt, Brandon S. Walker and Michael B. Cohen

      Article first published online: 17 DEC 2014 | DOI: 10.1002/cncy.21503

      Verification bias and classification bias are common in diagnostic accuracy studies of fine-needle aspiration biopsy. When combined, these two types of bias can interact to create more bias than would be expected from each type of bias acting independently.

    2. Cytomorphologic and clinicoradiologic analysis of primary nonhematologic central nervous system tumors with positive cerebrospinal fluid

      Cheng-Ying Ho, Christopher J. VandenBussche, Alison R. Huppman, Rabia Chaudhry and Syed Z. Ali

      Article first published online: 8 DEC 2014 | DOI: 10.1002/cncy.21502

      The current large, bi-institutional study provides a comprehensive clinical, radiological, and cytomorphologic analysis of primary nonhematologic central nervous system tumors with positive cerebrospinal fluid cytology. Useful information and illustrations are provided from a neuropathologist's perspective to help cytopathologists become familiar with common and rare entities that might be encountered on examination of cerebrospinal fluid specimens.

    3. Which are more correctly diagnosed: Conventional Papanicolaou smears or Thinprep samples? A comparative study of 9 years of external quality-assurance testing

      Margaret C. Cummings, Louise Marquart, Anita M. Pelecanos, Gail Perkins, David Papadimos, Peter O'Rourke and Jennifer A. Ross

      Article first published online: 8 DEC 2014 | DOI: 10.1002/cncy.21498

      The performance of Australasian and international laboratories in interpreting 23,373 conventional Papanicolaou smears is compared with that in interpreting 14,104 liquid-based cervical cytologic samples on external quality-assurance testing. There is greater accuracy for squamous dysplasia with ThinPrep samples for both groups, whereas, for endocervical adenocarcinoma in situ, Australasian laboratories perform better with conventional Pap smears, and international laboratories perform better with ThinPrep samples.

  3. Commentary

    1. Value of combined cytology and molecular information in the diagnosis of soft tissue tumors

      Jerzy Klijanienko, Gaelle Pierron, Xavier Sastre-Garau and Stamatios Theocharis

      Article first published online: 8 DEC 2014 | DOI: 10.1002/cncy.21496

      Fine-needle aspiration in soft tissue tumors is one of the most performed techniques for obtaining, in a noninvasive way, optimal material for morphological, immunohistochemical, and molecular purposes.

  4. Original Articles

    1. Endoscopic ultrasound-guided pancreatic fine-needle aspiration: Potential pitfalls in one institution's experience of 1212 procedures

      Joseph P. Bergeron, Kyle D. Perry, Patricia M. Houser and Jack Yang

      Article first published online: 19 NOV 2014 | DOI: 10.1002/cncy.21497

      Endoscopic ultrasound-guided fine-needle aspiration is a valuable tool for the diagnosis of pancreatic lesions, especially solid malignant tumors. Pathologists should be aware of the pitfalls in the cytologic diagnosis of pancreatic lesions that may significantly change the clinical management of the patients.

  5. Cytopathology Help Desk

  6. Original Articles

    1. Accuracy and risk of malignancy for diagnostic categories in urine cytology at a large tertiary institution

      Karen Chau, Lisa Rosen, Constantinos Coutsouvelis, Maly Fenelus, Ryan Brenkert, Melissa Klein, Gary Stone, Stephen Raab, Mohamed Aziz and Rubina Cocker

      Article first published online: 11 NOV 2014 | DOI: 10.1002/cncy.21477

      Our study demonstrates an overall sensitivity and specificity of cytologic diagnoses comparable to those previously reported and slightly higher values for both low-grade urothelial carcinoma of the bladder and high-grade urothelial carcinoma of the upper tract. A higher value for additive sensitivity and a discrete time analysis showing a decline in predicted positive cytology after the fourth cytology suggests that the optimal follow-up should include at least 4 consecutive urine cytology specimens over a time period averaging 22.2 months.

    2. Fine-needle aspiration biopsy of secondary neoplasms of the thyroid gland: A multi-institutional study of 62 cases

      Marc Pusztaszeri, He Wang, Edmund S. Cibas, Celeste N. Powers, Massimo Bongiovanni, Syed Ali, Kamal K. Khurana, Paul J. Michaels and William C. Faquin

      Article first published online: 4 NOV 2014 | DOI: 10.1002/cncy.21494

      Adenocarcinomas from the kidney, lung, breast, and colon along with squamous cell carcinomas represent the majority of secondary neoplasms of the thyroid gland (SNTGs). Fine-needle aspiration biopsy is a sensitive and accurate method for diagnosing SNTGs; however, diagnostic difficulties can occur, and knowledge of clinical history and judicious application of ancillary studies can increase the sensitivity and accuracy of fine-needle aspiration biopsy for detecting SNTGs.

    3. Low interobserver agreement in cytology grading of mucinous pancreatic neoplasms

      Carlie S. Sigel, Marcia Edelweiss, Leung Chu Tong, Joanna Magda, Handy Oen, Keith M. Sigel and Maureen F. Zakowski

      Article first published online: 29 OCT 2014 | DOI: 10.1002/cncy.21492

      Observers showed fair interobserver agreement for grading mucinous pancreatic neoplasms and low interobserver agreement for identifying neoplastic mucin. Knowledge of the cyst fluid carcinoembryonic antigen level was found to modestly improve interobserver agreement for low-grade neoplasms.

    4. Follow-up and clinical significance of unsatisfactory liquid-based Papanicolaou tests

      Christopher L. Owens, Diana S.M. Buist, Daniel Peterson, Aruna Kamineni, Sheila Weinmann, Tyler Ross, Andrew E. Williams, Azadeh Stark, Kenneth F. Adams, Chyke A. Doubeni and Terry S. Field

      Article first published online: 23 OCT 2014 | DOI: 10.1002/cncy.21490

      Various clinical factors influence the receipt of guideline-recommended follow-up studies after an unsatisfactory Papanicolaou test. The results of high-risk human papillomavirus testing demonstrate promise for stratifying the risk after an unsatisfactory Papanicolaou test.

    5. A cytomorphometric analysis of pulmonary and mediastinal granulomas: Differentiating histoplasmosis from sarcoidosis by fine-needle aspiration

      Michael P. Gailey, Matthew E. Keeney and Chris S. Jensen

      Article first published online: 15 OCT 2014 | DOI: 10.1002/cncy.21491

      The majority of cases of histoplasmosis and sarcoidosis can be differentiated by several cytologic parameters, such as the presence of necrosis, the number of granulomas, the morphology of granulomas, and the presence of giant cell infiltrates.

  7. Commentary

    1. An historic step for advanced cytopathology training in Canada

      Manon Auger, Shahidul Islam and Michele Weir

      Article first published online: 23 SEP 2014 | DOI: 10.1002/cncy.21485

      Advanced cytopathology training has finally obtained official recognition in Canada, having recently been assigned the newly developed status of “Area of Focused Competence” by the Royal College of Physicians and Surgeons of Canada. It is hoped that the trainees who graduate from these programs in cytopathology will be provided with the leadership and consultant skills to allow them to adapt and respond competently to the rapid evolving field of cytopathology.

  8. Original Articles

    1. Multiplatform comparison of molecular oncology tests performed on cytology specimens and formalin-fixed, paraffin-embedded tissue

      Michael P. Gailey, Aaron A. Stence, Chris S. Jensen and Deqin Ma

      Article first published online: 3 SEP 2014 | DOI: 10.1002/cncy.21476

      Cytology specimens are a cost-effective, reliable source for molecular oncology testing and may save patients from additional procedures when adequate material is available.

    2. Outcome of patients with negative and unsatisfactory cytologic specimens obtained by endobronchial ultrasound-guided transbronchial fine-needle aspiration of mediastinal lymph nodes

      Hiren J. Mehta, Nichole T. Tanner, Gerard Silvestri, Suzanne M. Simkovich, Clayton Shamblin, Stephanie R. Shaftman, Paul J. Nietert and Jack Yang

      Article first published online: 3 SEP 2014 | DOI: 10.1002/cncy.21482

      The current study evaluated the outcome of patients with negative and unsatisfactory cytologic specimens obtained by endobronchial ultrasound-guided transbronchial fine-needle aspiration of mediastinal lymph nodes in patients with known or suspected lung cancer. The results demonstrated that the negative predictive values of lymph nodes with cytologic diagnoses of negative and unsatisfactory were 93.9% (95% confidence interval, 91.6%-96.3%) and 88.2% (95% confidence interval, 81.4%-95.1%), respectively.


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