Cancer Cytopathology

Cover image for Vol. 123 Issue 1

Early View (Online Version of Record published before inclusion in an issue)

Edited By: Celeste N. Powers, MD, PhD

Impact Factor: 3.807

ISI Journal Citation Reports © Ranking: 2013: 15/76 (Pathology); 58/203 (Oncology)

Online ISSN: 1934-6638

Associated Title(s): Cancer, CA: A Cancer Journal for Clinicians

VIEW

  1. 1 - 23
  1. Original Articles

    1. Reducing indeterminate thyroid FNAs

      Andrew A. Renshaw and Edwin W. Gould

      Article first published online: 20 JAN 2015 | DOI: 10.1002/cncy.21520

      Modifying the Bethesda criteria can decrease the rate of indeterminate thyroid fine-needle aspiration diagnoses without a significant decrease in the risk of malignancy. Cytologists may find the data and methods described in this report useful for better defining the indeterminate rate in their own laboratories.

  2. Commentary

    1. Thyroid FNA: International perspectives from the European Congress of Cytopathology-Can we cross the bridge of classifications?

      Esther Diana Rossi, Marc Pusztaszeri, Fernando Schmitt, Massimo Bongiovanni, Ashish Chandra and William C. Faquin

      Article first published online: 14 JAN 2015 | DOI: 10.1002/cncy.21517

      The 38th European Congress of Cytology 2014, held in Geneva, Switzerland, offered a specific symposium concerning the Bethesda thyroid classification scheme. What emerged in that thyroid symposium, which was attended by all of the authors of this commentary, was the persistent need for a universally adopted thyroid fine-needle aspiration reporting system that can diagnose the same thyroid nodule in the same way anywhere in the world. Herein, the authors critically outline the advantages and limits of thyroid fine-needle aspiration classification schemes that were discussed at the symposium.

  3. Original Articles

    1. The role of liquid-based cytology and ancillary techniques in pleural and pericardic effusions: An institutional experience

      Esther Diana Rossi, Tommaso Bizzarro, Fernando Schmitt and Adhemar Longatto-Filho

      Article first published online: 14 JAN 2015 | DOI: 10.1002/cncy.21518

    2. Atypical urothelial tissue fragments in noninstrumented voided urine specimens are associated with low but significantly higher rates of urothelial neoplasia than benign-appearing urothelial tissue fragments

      Irem Onur, Dorothy L. Rosenthal and Christopher J. VandenBussche

      Article first published online: 13 JAN 2015 | DOI: 10.1002/cncy.21519

      The authors previously demonstrated a small, statistically insignificant increased risk of low-grade urothelial carcinoma when benign-appearing urothelial tissue fragments are found in voided urine specimens. Comparatively, the results of the current study demonstrate an increased risk of high-grade urothelial carcinoma, but not low-grade urothelial carcinoma, when urothelial tissue fragments in voided urine specimens contain cytologic atypia.

    3. Benign-appearing urothelial tissue fragments in noninstrumented voided urine specimens are associated with low rates of urothelial neoplasia

      Irem Onur, Dorothy L. Rosenthal and Christopher J. VandenBussche

      Article first published online: 13 JAN 2015 | DOI: 10.1002/cncy.21501

      The presence of urothelial tissue fragments in voided urine specimens is believed to be associated with an increased risk of urothelial neoplasia, although to the authors' knowledge only a few studies have investigated this association over the last several decades. The current retrospective analysis of 274 voided, noninstrumented urine specimens demonstrates only a small, statistically insignificant increased risk of low-grade urothelial neoplasia when benign-appearing urothelial tissue fragments are present.

    4. Fine-needle aspiration cytology of the solid variant of papillary thyroid carcinoma: A study of 13 cases with clinical, histologic, and ultrasound correlations

      Tamar A. Giorgadze, Theresa Scognamiglio and Grace C. H. Yang

      Article first published online: 8 JAN 2015 | DOI: 10.1002/cncy.21504

      The solid variant of papillary thyroid carcinoma comprises a heterogeneous group of tumors. The tumors that have cytomorphologic patterns of cohesive, syncytial-type tissue fragments or microfollicules/trabeculae are circumscribed and indolent, whereas tumors that have dyshesive single cells are infiltrative and potentially aggressive.

    5. Cytomorphologic features that distinguish schwannoma from other low-grade spindle cell lesions

      Ivan Chebib, Francis J. Hornicek, G. Petur Nielsen and Vikram Deshpande

      Article first published online: 8 JAN 2015 | DOI: 10.1002/cncy.21506

      The objective of the current study was to identify key diagnostic cytological criteria for the diagnosis of schwannoma and to distinguish it from its common mimics. Cohesive tissue fragments with fibrillary/fibrous stroma, intranuclear inclusions, marked nuclear pleomorphism, and the absence of spindled cells with bipolar cytoplasmic processes are strongly suggestive of schwannoma and assist in excluding other low-grade spindle cell tumors from the diagnosis.

    6. Strategies for improving diagnostic accuracy of biliary strictures

      Marcela Salomao, Tamas A. Gonda, Elizabeth Margolskee, Vasco Eguia, Helen Remotti, John M. Poneros, Amrita Sethi and Anjali Saqi

      Article first published online: 6 JAN 2015 | DOI: 10.1002/cncy.21509

      Key cytological features for discriminating between nonneoplastic and neoplastic biliary brushings are described. Also, the article identifies sampling methods (cytology, biopsy, and/or FISH) that improve the diagnostic yield of pancreatobiliary tumors.

    7. Cytomorphological features of ALK-positive lung adenocarcinomas: Psammoma bodies and signet ring cells

      Fresia Pareja, John P. Crapanzano, Mahesh M. Mansukhani, William A. Bulman and Anjali Saqi

      Article first published online: 29 DEC 2014 | DOI: 10.1002/cncy.21507

      Correlation between histology and genotype has been described in lung adenocarcinomas. Psammoma bodies and signet ring cells are salient morphological features associated with anaplastic lymphoma kinase (ALK)-positive lung adenocarcinomas and are identifiable on cytological specimens.

    8. Combination of p16INK4a-Ki67 immunocytology and hpv polymerase chain reaction for the noninvasive analysis of HPV involvement in head and neck cancer

      Maximilian Linxweiler, Florian Bochen, Silke Wemmert, Cornelia Lerner, Andrea Hasenfus, Rainer Maria Bohle, Basel Al-Kadah, Zoltan Ferenc Takacs, Sigrun Smola and Bernhard Schick

      Article first published online: 29 DEC 2014 | DOI: 10.1002/cncy.21512

      Simultaneous immunocytochemical detection of p16INK4a and Ki67 was performed on liquid-based cytological smears from 45 head and neck cancer patients and 20 control patients, and the same cytological material was used for the detection of HPV DNA by specific PCR. Combining both techniques, we could reliably discriminate between latent and carcinogenic HPV infections as well as HPV-negative cases and thus provide information on the prognosis of HNSCC patients and facilitate therapeutic decisions.

    9. ARID1A is a useful marker of malignancy in peritoneal washings for endometrial carcinoma

      Zoltan Nagymanyoki, George L. Mutter, Jason L. Hornick and Edmund S. Cibas

      Article first published online: 29 DEC 2014 | DOI: 10.1002/cncy.21514

      ARID1A (AT-rich interactive domain 1A gene) is a newly identified tumor suppressor gene in endometrioid carcinomas. This article discusses the potential use of ARID1A immunohistochemistry to identify malignant endometrial cells in peritoneal washings.

  4. Cytopathology Help Desk

    1. Next-generation sequencing and the cytopathologist

      Catherine I. Dumur and Adele O. Kraft

      Article first published online: 29 DEC 2014 | DOI: 10.1002/cncy.21515

  5. Original Articles

    1. Cytologic diagnostic approach to poorly differentiated thyroid carcinoma: A single-institution study

      Shubhada V. Kane and Tanvi Paliwal Sharma

      Article first published online: 29 DEC 2014 | DOI: 10.1002/cncy.21500

      The cytologic diagnostic criteria for poorly differentiated thyroid carcinoma need to be standardized by collaborative efforts among tertiary cancer centers. A prompt diagnosis is the key feature for planning multimodality treatment and improving survival.

    2. Interpretation of p16INK4a/Ki-67 dual immunostaining for the triage of human papillomavirus-positive women by experts and nonexperts in cervical cytology

      Elena Allia, Guglielmo Ronco, Anna Coccia, Patrizia Luparia, Luigia Macrì, Corinna Fiorito, Francesca Maletta, Cristina Deambrogio, Sara Tunesi, Laura De Marco, Anna Gillio-Tos, Anna Sapino and Bruno Ghiringhello

      Article first published online: 22 DEC 2014 | DOI: 10.1002/cncy.21511

      In the current study, p16INK4a/Ki-67 immunostaining demonstrated good reproducibility and specificity when triaging women who were positive for the human papillomavirus. Dual-staining interpretation can be performed, after brief training, even by staff who are not experts in the morphological interpretation of cytology.

    3. Detection of ALK rearrangements in malignant pleural effusion cell blocks from patients with advanced non-small cell lung cancer: A comparison of Ventana immunohistochemistry and fluorescence in situ hybridization

      Weiya Wang, Yuan Tang, Jinnan Li, Lili Jiang, Yong Jiang and Xueying Su

      Article first published online: 19 DEC 2014 | DOI: 10.1002/cncy.21510

      Malignant pleural effusion cell blocks represent an alternative to tumor tissues for the detection of anaplastic lymphoma kinase (ALK) rearrangement in patients with advanced non-small cell lung cancer. The Ventana ALK immunohistochemistry assay, which lacks any limitations concerning the number of tumor cells, is a sensitive and specific method for screening ALK rearrangements and demonstrates high agreement with fluorescence in situ hybridization results.

    4. You have full text access to this OnlineOpen article
      Assessment of EGFR and KRAS mutation status from FNAs and core-needle biopsies of nonsmall cell lung cancer

      Maria D. Lozano, Tania Labiano, Jose Echeveste, Alfonso Gurpide, Salvador Martín-Algarra, Guili Zhang, Abha Sharma and John F. Palma

      Article first published online: 19 DEC 2014 | DOI: 10.1002/cncy.21513

      EGFR or KRAS mutation status can be successfully determined in Papanicolaou-stained fine-needle aspiration samples and hematoxylin and eosin-stained core-needle biopsy samples using polymerase chain reaction-based tests. The findings from this pilot study highlight the feasibility of rapid and accurate mutation testing for patient samples derived from minimally invasive diagnostic procedures or from samples with limited available tissue.

  6. Review Articles

    1. Biospecimen repositories and cytopathology

      Savitri Krishnamurthy

      Article first published online: 18 DEC 2014 | DOI: 10.1002/cncy.21505

      The potential for biobanking of cytopathology specimen is excellent. Further studies are needed to establish definite protocols for biobanking of thes specimens

  7. Original Articles

    1. Verification and classification bias interactions in diagnostic test accuracy studies for fine-needle aspiration biopsy

      Robert L. Schmidt, Brandon S. Walker and Michael B. Cohen

      Article first published online: 17 DEC 2014 | DOI: 10.1002/cncy.21503

      Verification bias and classification bias are common in diagnostic accuracy studies of fine-needle aspiration biopsy. When combined, these two types of bias can interact to create more bias than would be expected from each type of bias acting independently.

    2. Cytomorphologic and clinicoradiologic analysis of primary nonhematologic central nervous system tumors with positive cerebrospinal fluid

      Cheng-Ying Ho, Christopher J. VandenBussche, Alison R. Huppman, Rabia Chaudhry and Syed Z. Ali

      Article first published online: 8 DEC 2014 | DOI: 10.1002/cncy.21502

      The current large, bi-institutional study provides a comprehensive clinical, radiological, and cytomorphologic analysis of primary nonhematologic central nervous system tumors with positive cerebrospinal fluid cytology. Useful information and illustrations are provided from a neuropathologist's perspective to help cytopathologists become familiar with common and rare entities that might be encountered on examination of cerebrospinal fluid specimens.

    3. Which are more correctly diagnosed: Conventional Papanicolaou smears or Thinprep samples? A comparative study of 9 years of external quality-assurance testing

      Margaret C. Cummings, Louise Marquart, Anita M. Pelecanos, Gail Perkins, David Papadimos, Peter O'Rourke and Jennifer A. Ross

      Article first published online: 8 DEC 2014 | DOI: 10.1002/cncy.21498

      The performance of Australasian and international laboratories in interpreting 23,373 conventional Papanicolaou smears is compared with that in interpreting 14,104 liquid-based cervical cytologic samples on external quality-assurance testing. There is greater accuracy for squamous dysplasia with ThinPrep samples for both groups, whereas, for endocervical adenocarcinoma in situ, Australasian laboratories perform better with conventional Pap smears, and international laboratories perform better with ThinPrep samples.

  8. Commentary

    1. Value of combined cytology and molecular information in the diagnosis of soft tissue tumors

      Jerzy Klijanienko, Gaelle Pierron, Xavier Sastre-Garau and Stamatios Theocharis

      Article first published online: 8 DEC 2014 | DOI: 10.1002/cncy.21496

      Fine-needle aspiration in soft tissue tumors is one of the most performed techniques for obtaining, in a noninvasive way, optimal material for morphological, immunohistochemical, and molecular purposes.

  9. Original Articles

    1. Endoscopic ultrasound-guided pancreatic fine-needle aspiration: Potential pitfalls in one institution's experience of 1212 procedures

      Joseph P. Bergeron, Kyle D. Perry, Patricia M. Houser and Jack Yang

      Article first published online: 19 NOV 2014 | DOI: 10.1002/cncy.21497

      Endoscopic ultrasound-guided fine-needle aspiration is a valuable tool for the diagnosis of pancreatic lesions, especially solid malignant tumors. Pathologists should be aware of the pitfalls in the cytologic diagnosis of pancreatic lesions that may significantly change the clinical management of the patients.

    2. Outcome of patients with negative and unsatisfactory cytologic specimens obtained by endobronchial ultrasound-guided transbronchial fine-needle aspiration of mediastinal lymph nodes

      Hiren J. Mehta, Nichole T. Tanner, Gerard Silvestri, Suzanne M. Simkovich, Clayton Shamblin, Stephanie R. Shaftman, Paul J. Nietert and Jack Yang

      Article first published online: 3 SEP 2014 | DOI: 10.1002/cncy.21482

      The current study evaluated the outcome of patients with negative and unsatisfactory cytologic specimens obtained by endobronchial ultrasound-guided transbronchial fine-needle aspiration of mediastinal lymph nodes in patients with known or suspected lung cancer. The results demonstrated that the negative predictive values of lymph nodes with cytologic diagnoses of negative and unsatisfactory were 93.9% (95% confidence interval, 91.6%-96.3%) and 88.2% (95% confidence interval, 81.4%-95.1%), respectively.

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