A 4-MicroRNA signature can discriminate primary lymphomas from anaplastic carcinomas in thyroid cytology smears
Ambrogio Fassina, Rocco Cappellesso, Francesca Simonato, Maayan Siri, Laura Ventura, Francesca Tosato, Lill-Tove Busund, Maria Rosa Pelizzo and Matteo Fassan
Article first published online: 10 DEC 2013 | DOI: 10.1002/cncy.21383
Histotype-specific microRNA signatures can provide new insight into the molecular mechanisms of thyroid carcinogenesis. The tested signature of 4 microRNAs in this study is a promising diagnostic tool for differentiating anaplastic thyroid lymphoma from primary thyroid lymphoma and non-neoplastic multinodular goiter, even in the presence of scant material obtained from minimally invasive procedures.