Cancer Cytopathology

Cover image for Vol. 123 Issue 2

Early View (Online Version of Record published before inclusion in an issue)

Edited By: Celeste N. Powers, MD, PhD

Impact Factor: 3.807

ISI Journal Citation Reports © Ranking: 2013: 15/76 (Pathology); 58/203 (Oncology)

Online ISSN: 1934-6638

Associated Title(s): Cancer, CA: A Cancer Journal for Clinicians


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  1. Original Articles

    1. Microphthalmia transcription factor immunohistochemistry for FNA biopsy of ocular malignant melanoma

      Carmen M. Perrino, Jeff F. Wang and Brian T. Collins

      Article first published online: 24 FEB 2015 | DOI: 10.1002/cncy.21531

      This study is an evaluation of immunohistochemistry in the workup of fine-needle aspiration biopsies of ocular malignant melanoma and especially the new marker microphthalmia transcription factor. In addition, we show that microphthalmia transcription factor immunohistochemistry may be reliably performed on alcohol-fixed, Papanicolaou-stained direct smears.

    2. FNA, core biopsy, or both for the diagnosis of lung carcinoma: Obtaining sufficient tissue for a specific diagnosis and molecular testing

      Shana M. Coley, John P. Crapanzano and Anjali Saqi

      Article first published online: 24 FEB 2015 | DOI: 10.1002/cncy.21527

      Lung lesions are frequently sampled under computed tomography guidance. Fine-needle aspiration, core biopsy, and both are equivalent at providing tissue for histological, immunohistochemical, and molecular diagnoses.

  2. Clinician's Corner

    1. Primary human papillomavirus testing

      David Chelmow

      Article first published online: 24 FEB 2015 | DOI: 10.1002/cncy.21525

  3. Original Articles

    1. Comprehensive mutation profiling by next-generation sequencing of effusion fluids from patients with high-grade serous ovarian carcinoma

      Ronak H. Shah, Sasinya N. Scott, A. Rose Brannon, Douglas A. Levine, Oscar Lin and Michael F. Berger

      Article first published online: 5 FEB 2015 | DOI: 10.1002/cncy.21522

      Cytology specimens represent suitable material for high-throughput sequencing. In this study, all mutations described by The Cancer Genome Atlas are independently identified in samples of effusion fluid.

  4. Clinician's Corner

  5. Original Articles

    1. Reducing indeterminate thyroid FNAs

      Andrew A. Renshaw and Edwin W. Gould

      Article first published online: 20 JAN 2015 | DOI: 10.1002/cncy.21520

      Modifying the Bethesda criteria can decrease the rate of indeterminate thyroid fine-needle aspiration diagnoses without a significant decrease in the risk of malignancy. Cytologists may find the data and methods described in this report useful for better defining the indeterminate rate in their own laboratories.

  6. Commentary

    1. Thyroid FNA: International perspectives from the European Congress of Cytopathology-Can we cross the bridge of classifications?

      Esther Diana Rossi, Marc Pusztaszeri, Fernando Schmitt, Massimo Bongiovanni, Ashish Chandra and William C. Faquin

      Article first published online: 14 JAN 2015 | DOI: 10.1002/cncy.21517

      The 38th European Congress of Cytology 2014, held in Geneva, Switzerland, offered a specific symposium concerning the Bethesda thyroid classification scheme. What emerged in that thyroid symposium, which was attended by all of the authors of this commentary, was the persistent need for a universally adopted thyroid fine-needle aspiration reporting system that can diagnose the same thyroid nodule in the same way anywhere in the world. Herein, the authors critically outline the advantages and limits of thyroid fine-needle aspiration classification schemes that were discussed at the symposium.

  7. Original Articles

    1. The role of liquid-based cytology and ancillary techniques in pleural and pericardic effusions: An institutional experience

      Esther Diana Rossi, Tommaso Bizzarro, Fernando Schmitt and Adhemar Longatto-Filho

      Article first published online: 14 JAN 2015 | DOI: 10.1002/cncy.21518

    2. Atypical urothelial tissue fragments in noninstrumented voided urine specimens are associated with low but significantly higher rates of urothelial neoplasia than benign-appearing urothelial tissue fragments

      Irem Onur, Dorothy L. Rosenthal and Christopher J. VandenBussche

      Article first published online: 13 JAN 2015 | DOI: 10.1002/cncy.21519

      The authors previously demonstrated a small, statistically insignificant increased risk of low-grade urothelial carcinoma when benign-appearing urothelial tissue fragments are found in voided urine specimens. Comparatively, the results of the current study demonstrate an increased risk of high-grade urothelial carcinoma, but not low-grade urothelial carcinoma, when urothelial tissue fragments in voided urine specimens contain cytologic atypia.

    3. Benign-appearing urothelial tissue fragments in noninstrumented voided urine specimens are associated with low rates of urothelial neoplasia

      Irem Onur, Dorothy L. Rosenthal and Christopher J. VandenBussche

      Article first published online: 13 JAN 2015 | DOI: 10.1002/cncy.21501

      The presence of urothelial tissue fragments in voided urine specimens is believed to be associated with an increased risk of urothelial neoplasia, although to the authors' knowledge only a few studies have investigated this association over the last several decades. The current retrospective analysis of 274 voided, noninstrumented urine specimens demonstrates only a small, statistically insignificant increased risk of low-grade urothelial neoplasia when benign-appearing urothelial tissue fragments are present.

    4. Cytomorphologic features that distinguish schwannoma from other low-grade spindle cell lesions

      Ivan Chebib, Francis J. Hornicek, G. Petur Nielsen and Vikram Deshpande

      Article first published online: 8 JAN 2015 | DOI: 10.1002/cncy.21506

      The objective of the current study was to identify key diagnostic cytological criteria for the diagnosis of schwannoma and to distinguish it from its common mimics. Cohesive tissue fragments with fibrillary/fibrous stroma, intranuclear inclusions, marked nuclear pleomorphism, and the absence of spindled cells with bipolar cytoplasmic processes are strongly suggestive of schwannoma and assist in excluding other low-grade spindle cell tumors from the diagnosis.

    5. Strategies for improving diagnostic accuracy of biliary strictures

      Marcela Salomao, Tamas A. Gonda, Elizabeth Margolskee, Vasco Eguia, Helen Remotti, John M. Poneros, Amrita Sethi and Anjali Saqi

      Article first published online: 6 JAN 2015 | DOI: 10.1002/cncy.21509

      Key cytological features for discriminating between nonneoplastic and neoplastic biliary brushings are described. Also, the article identifies sampling methods (cytology, biopsy, and/or FISH) that improve the diagnostic yield of pancreatobiliary tumors.

    6. Cytomorphological features of ALK-positive lung adenocarcinomas: Psammoma bodies and signet ring cells

      Fresia Pareja, John P. Crapanzano, Mahesh M. Mansukhani, William A. Bulman and Anjali Saqi

      Article first published online: 29 DEC 2014 | DOI: 10.1002/cncy.21507

      Correlation between histology and genotype has been described in lung adenocarcinomas. Psammoma bodies and signet ring cells are salient morphological features associated with anaplastic lymphoma kinase (ALK)-positive lung adenocarcinomas and are identifiable on cytological specimens.

    7. Combination of p16INK4a-Ki67 immunocytology and hpv polymerase chain reaction for the noninvasive analysis of HPV involvement in head and neck cancer

      Maximilian Linxweiler, Florian Bochen, Silke Wemmert, Cornelia Lerner, Andrea Hasenfus, Rainer Maria Bohle, Basel Al-Kadah, Zoltan Ferenc Takacs, Sigrun Smola and Bernhard Schick

      Article first published online: 29 DEC 2014 | DOI: 10.1002/cncy.21512

      Simultaneous immunocytochemical detection of p16INK4a and Ki67 was performed on liquid-based cytological smears from 45 head and neck cancer patients and 20 control patients, and the same cytological material was used for the detection of HPV DNA by specific PCR. Combining both techniques, we could reliably discriminate between latent and carcinogenic HPV infections as well as HPV-negative cases and thus provide information on the prognosis of HNSCC patients and facilitate therapeutic decisions.

    8. ARID1A is a useful marker of malignancy in peritoneal washings for endometrial carcinoma

      Zoltan Nagymanyoki, George L. Mutter, Jason L. Hornick and Edmund S. Cibas

      Article first published online: 29 DEC 2014 | DOI: 10.1002/cncy.21514

      ARID1A (AT-rich interactive domain 1A gene) is a newly identified tumor suppressor gene in endometrioid carcinomas. This article discusses the potential use of ARID1A immunohistochemistry to identify malignant endometrial cells in peritoneal washings.

    9. Interpretation of p16INK4a/Ki-67 dual immunostaining for the triage of human papillomavirus-positive women by experts and nonexperts in cervical cytology

      Elena Allia, Guglielmo Ronco, Anna Coccia, Patrizia Luparia, Luigia Macrì, Corinna Fiorito, Francesca Maletta, Cristina Deambrogio, Sara Tunesi, Laura De Marco, Anna Gillio-Tos, Anna Sapino and Bruno Ghiringhello

      Article first published online: 22 DEC 2014 | DOI: 10.1002/cncy.21511

      In the current study, p16INK4a/Ki-67 immunostaining demonstrated good reproducibility and specificity when triaging women who were positive for the human papillomavirus. Dual-staining interpretation can be performed, after brief training, even by staff who are not experts in the morphological interpretation of cytology.

    10. You have full text access to this OnlineOpen article
      Assessment of EGFR and KRAS mutation status from FNAs and core-needle biopsies of nonsmall cell lung cancer

      Maria D. Lozano, Tania Labiano, Jose Echeveste, Alfonso Gurpide, Salvador Martín-Algarra, Guili Zhang, Abha Sharma and John F. Palma

      Article first published online: 19 DEC 2014 | DOI: 10.1002/cncy.21513

      EGFR or KRAS mutation status can be successfully determined in Papanicolaou-stained fine-needle aspiration samples and hematoxylin and eosin-stained core-needle biopsy samples using polymerase chain reaction-based tests. The findings from this pilot study highlight the feasibility of rapid and accurate mutation testing for patient samples derived from minimally invasive diagnostic procedures or from samples with limited available tissue.

  8. Review Articles

    1. Biospecimen repositories and cytopathology

      Savitri Krishnamurthy

      Article first published online: 18 DEC 2014 | DOI: 10.1002/cncy.21505

      The potential for biobanking of cytopathology specimen is excellent. Further studies are needed to establish definite protocols for biobanking of thes specimens

  9. Original Articles

    1. Verification and classification bias interactions in diagnostic test accuracy studies for fine-needle aspiration biopsy

      Robert L. Schmidt, Brandon S. Walker and Michael B. Cohen

      Article first published online: 17 DEC 2014 | DOI: 10.1002/cncy.21503

      Verification bias and classification bias are common in diagnostic accuracy studies of fine-needle aspiration biopsy. When combined, these two types of bias can interact to create more bias than would be expected from each type of bias acting independently.

  10. Commentary

    1. Value of combined cytology and molecular information in the diagnosis of soft tissue tumors

      Jerzy Klijanienko, Gaelle Pierron, Xavier Sastre-Garau and Stamatios Theocharis

      Article first published online: 8 DEC 2014 | DOI: 10.1002/cncy.21496

      Fine-needle aspiration in soft tissue tumors is one of the most performed techniques for obtaining, in a noninvasive way, optimal material for morphological, immunohistochemical, and molecular purposes.


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