Cancer Cytopathology

Cover image for Vol. 123 Issue 3

Early View (Online Version of Record published before inclusion in an issue)

Edited By: Celeste N. Powers, MD, PhD

Impact Factor: 3.807

ISI Journal Citation Reports © Ranking: 2013: 15/76 (Pathology); 58/203 (Oncology)

Online ISSN: 1934-6638

Associated Title(s): Cancer, CA: A Cancer Journal for Clinicians


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  1. Original Articles

    1. Multiplex sequencing for EZH2, CD79B, and MYD88 mutations using archival cytospin preparations from B-cell non-Hodgkin lymphoma aspirates previously tested for MYC rearrangement and IGH/BCL2 translocation

      Gilda da Cunha Santos, Mauro Ajaj Saieg, Hyang Mi Ko, William R. Geddie, Scott L. Boerner, Kenneth J. Craddock, Michael Crump and Denis Bailey

      Article first published online: 23 MAR 2015 | DOI: 10.1002/cncy.21535

      Cytospin preparations (CP) stored at −20°C for up to 6 years are a reliable source of high-quality genomic material for multiplex sequencing. Successful detection of EZH2 (Y641), CD79B (Y196), and MYD88 (L265) mutations can be achieved using material scraped from archival CP obtained from B-cell non-Hodgkin lymphoma aspirates of cases previously tested for MYC rearrangement and IGH/BCL2 translocation.

    2. Cytopathology of pulmonary adenocarcinoma with a single histological pattern using the proposed International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society (IASLC/ATS/ERS) classification

      Erika F. Rodriguez, Sanja Dacic, Liron Pantanowitz, Walid E. Khalbuss and Sara E. Monaco

      Article first published online: 18 MAR 2015 | DOI: 10.1002/cncy.21532

      The current study investigates the cytological features of lung adenocarcinoma subtypes proposed by the International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society (IASLC/ATS/ERS) from cases with histology showing a single pattern. The findings demonstrate that some architectural and nuclear features may be helpful in distinguishing the prognostically adverse solid pattern from other patterns.

  2. Cytopathology Help Desk TOC CATEGORY: Other

  3. Review Article

    1. Intraoperative consultation on pediatric central nervous system tumors by squash cytology

      César R. Lacruz, Inmaculada Catalina-Fernández, Ricardo H. Bardales, José Pimentel, Dolores López-Presa and Javier Sáenz-Santamaría

      Article first published online: 12 MAR 2015 | DOI: 10.1002/cncy.21537

      In pediatric central nervous system tumors, squash cytology improves the diagnostic accuracy and protects tissue from freezing artifacts; its use is recommended in every case. A Romanowsky-stained preparation provides valuable information about the background features of the examined lesion and complements conventional hematoxylin and eosin and Papanicolaou staining methods.

  4. Erratum

    1. You have free access to this content
  5. Original Articles

    1. HNF1β and S100A1 are useful biomarkers for distinguishing renal oncocytoma and chromophobe renal cell carcinoma in FNA and core needle biopsies

      James R. Conner, Michelle S. Hirsch and Vickie Y. Jo

      Article first published online: 4 MAR 2015 | DOI: 10.1002/cncy.21530

      The distinction between renal oncocytoma and chromophobe renal cell carcinoma can be challenging, especially in fine-needle aspiration and core biopsies. Immunoreactivity for both HNF1β and S100A1 is present in a significantly greater proportion of oncocytomas than in chromophobe renal cell carcinomas, and these immunohistochemical markers may aid in the differential diagnosis.

    2. Microphthalmia transcription factor immunohistochemistry for FNA biopsy of ocular malignant melanoma

      Carmen M. Perrino, Jeff F. Wang and Brian T. Collins

      Article first published online: 24 FEB 2015 | DOI: 10.1002/cncy.21531

      This study is an evaluation of immunohistochemistry in the workup of fine-needle aspiration biopsies of ocular malignant melanoma and especially the new marker microphthalmia transcription factor. In addition, we show that microphthalmia transcription factor immunohistochemistry may be reliably performed on alcohol-fixed, Papanicolaou-stained direct smears.

    3. FNA, core biopsy, or both for the diagnosis of lung carcinoma: Obtaining sufficient tissue for a specific diagnosis and molecular testing

      Shana M. Coley, John P. Crapanzano and Anjali Saqi

      Article first published online: 24 FEB 2015 | DOI: 10.1002/cncy.21527

      Lung lesions are frequently sampled under computed tomography guidance. Fine-needle aspiration, core biopsy, and both are equivalent at providing tissue for histological, immunohistochemical, and molecular diagnoses.

  6. Clinician's Corner

  7. Original Articles

    1. Comprehensive mutation profiling by next-generation sequencing of effusion fluids from patients with high-grade serous ovarian carcinoma

      Ronak H. Shah, Sasinya N. Scott, A. Rose Brannon, Douglas A. Levine, Oscar Lin and Michael F. Berger

      Article first published online: 5 FEB 2015 | DOI: 10.1002/cncy.21522

      Cytology specimens represent suitable material for high-throughput sequencing. In this study, all mutations described by The Cancer Genome Atlas are independently identified in samples of effusion fluid.

    2. Reducing indeterminate thyroid FNAs

      Andrew A. Renshaw and Edwin W. Gould

      Article first published online: 20 JAN 2015 | DOI: 10.1002/cncy.21520

      Modifying the Bethesda criteria can decrease the rate of indeterminate thyroid fine-needle aspiration diagnoses without a significant decrease in the risk of malignancy. Cytologists may find the data and methods described in this report useful for better defining the indeterminate rate in their own laboratories.

  8. Commentary

    1. Thyroid FNA: International perspectives from the European Congress of Cytopathology-Can we cross the bridge of classifications?

      Esther Diana Rossi, Marc Pusztaszeri, Fernando Schmitt, Massimo Bongiovanni, Ashish Chandra and William C. Faquin

      Article first published online: 14 JAN 2015 | DOI: 10.1002/cncy.21517

      The 38th European Congress of Cytology 2014, held in Geneva, Switzerland, offered a specific symposium concerning the Bethesda thyroid classification scheme. What emerged in that thyroid symposium, which was attended by all of the authors of this commentary, was the persistent need for a universally adopted thyroid fine-needle aspiration reporting system that can diagnose the same thyroid nodule in the same way anywhere in the world. Herein, the authors critically outline the advantages and limits of thyroid fine-needle aspiration classification schemes that were discussed at the symposium.

  9. Original Articles

    1. The role of liquid-based cytology and ancillary techniques in pleural and pericardic effusions: An institutional experience

      Esther Diana Rossi, Tommaso Bizzarro, Fernando Schmitt and Adhemar Longatto-Filho

      Article first published online: 14 JAN 2015 | DOI: 10.1002/cncy.21518

    2. Strategies for improving diagnostic accuracy of biliary strictures

      Marcela Salomao, Tamas A. Gonda, Elizabeth Margolskee, Vasco Eguia, Helen Remotti, John M. Poneros, Amrita Sethi and Anjali Saqi

      Article first published online: 6 JAN 2015 | DOI: 10.1002/cncy.21509

      Key cytological features for discriminating between nonneoplastic and neoplastic biliary brushings are described. Also, the article identifies sampling methods (cytology, biopsy, and/or FISH) that improve the diagnostic yield of pancreatobiliary tumors.

    3. Combination of p16INK4a-Ki67 immunocytology and hpv polymerase chain reaction for the noninvasive analysis of HPV involvement in head and neck cancer

      Maximilian Linxweiler, Florian Bochen, Silke Wemmert, Cornelia Lerner, Andrea Hasenfus, Rainer Maria Bohle, Basel Al-Kadah, Zoltan Ferenc Takacs, Sigrun Smola and Bernhard Schick

      Article first published online: 29 DEC 2014 | DOI: 10.1002/cncy.21512

      Simultaneous immunocytochemical detection of p16INK4a and Ki67 was performed on liquid-based cytological smears from 45 head and neck cancer patients and 20 control patients, and the same cytological material was used for the detection of HPV DNA by specific PCR. Combining both techniques, we could reliably discriminate between latent and carcinogenic HPV infections as well as HPV-negative cases and thus provide information on the prognosis of HNSCC patients and facilitate therapeutic decisions.

    4. ARID1A is a useful marker of malignancy in peritoneal washings for endometrial carcinoma

      Zoltan Nagymanyoki, George L. Mutter, Jason L. Hornick and Edmund S. Cibas

      Article first published online: 29 DEC 2014 | DOI: 10.1002/cncy.21514

      ARID1A (AT-rich interactive domain 1A gene) is a newly identified tumor suppressor gene in endometrioid carcinomas. This article discusses the potential use of ARID1A immunohistochemistry to identify malignant endometrial cells in peritoneal washings.

    5. Interpretation of p16INK4a/Ki-67 dual immunostaining for the triage of human papillomavirus-positive women by experts and nonexperts in cervical cytology

      Elena Allia, Guglielmo Ronco, Anna Coccia, Patrizia Luparia, Luigia Macrì, Corinna Fiorito, Francesca Maletta, Cristina Deambrogio, Sara Tunesi, Laura De Marco, Anna Gillio-Tos, Anna Sapino and Bruno Ghiringhello

      Article first published online: 22 DEC 2014 | DOI: 10.1002/cncy.21511

      In the current study, p16INK4a/Ki-67 immunostaining demonstrated good reproducibility and specificity when triaging women who were positive for the human papillomavirus. Dual-staining interpretation can be performed, after brief training, even by staff who are not experts in the morphological interpretation of cytology.

    6. You have full text access to this OnlineOpen article
      Assessment of EGFR and KRAS mutation status from FNAs and core-needle biopsies of nonsmall cell lung cancer

      Maria D. Lozano, Tania Labiano, Jose Echeveste, Alfonso Gurpide, Salvador Martín-Algarra, Guili Zhang, Abha Sharma and John F. Palma

      Article first published online: 19 DEC 2014 | DOI: 10.1002/cncy.21513

      EGFR or KRAS mutation status can be successfully determined in Papanicolaou-stained fine-needle aspiration samples and hematoxylin and eosin-stained core-needle biopsy samples using polymerase chain reaction-based tests. The findings from this pilot study highlight the feasibility of rapid and accurate mutation testing for patient samples derived from minimally invasive diagnostic procedures or from samples with limited available tissue.


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