Cancer Cytopathology

Cover image for Vol. 124 Issue 1

Early View (Online Version of Record published before inclusion in an issue)

Edited By: Celeste N. Powers, MD, PhD

Impact Factor: 3.737

ISI Journal Citation Reports © Ranking: 2014: 13/76 (Pathology); 67/211 (Oncology)

Online ISSN: 1934-6638

Associated Title(s): Cancer, CA: A Cancer Journal for Clinicians

VIEW

  1. 1 - 35
  1. Commentary

    1. Validation of immunocytochemistry as a morphomolecular technique

      Perry Maxwell and Manuel Salto-Tellez

      Article first published online: 2 FEB 2016 | DOI: 10.1002/cncy.21692

      • image

      Cytology-specific validations are at the core of the management of uncertainty and in meeting accreditation standards. We advocate that the main cytology preanalytic variables contributing toward quality should be identified and controlled. In addition, the validation of Immunocytochemistry (ICC) should take the same rigorous approach that other molecular pathology techniques follow. A three-step validation protocol is offered here where the end result is a comprehensive, morphomolecular approach to ICC, with an emphasis on therapeutic ICC.

  2. Cytopathology Help Desk

  3. Original Articles

    1. Round cell sarcoma with CIC-DUX4 gene fusion: Discussion of the distinctive cytomorphologic, immunohistochemical, and molecular features in the differential diagnosis of round cell tumors

      Ivan Chebib and Vickie Y. Jo

      Article first published online: 22 JAN 2016 | DOI: 10.1002/cncy.21685

      • image
      • image
      • image
      • image
      • image
      • image
      • image
      • image
      • image

      A subset of undifferentiated round cell sarcomas is now known to be characterized by CIC-DUX4 gene fusion, and may be difficult to distinguish from Ewing sarcoma and other round cell tumors. The cytomorphologic, immunohistochemical, and molecular features with attention to the challenging differential diagnosis are herein reviewed.

    2. Clinical performance of the Food and Drug Administration–Approved high-risk HPV test for the detection of high-grade cervicovaginal lesions

      Haijun Zhou, Roxanne R. Mody, Eric Luna, Donna Armylagos, Jiaqiong Xu, Mary R. Schwartz, Dina R. Mody and Yimin Ge

      Article first published online: 15 JAN 2016 | DOI: 10.1002/cncy.21687

      In clinical practice, the high-risk human papillomavirus test alone is not significantly superior to the Papanicolaou test as a primary screening method for cervicovaginal lesions. Cytology–human papillomavirus cotesting currently remains the best strategy for detecting high-grade cervicovaginal lesions.

  4. Clinician's Corner

  5. Original Articles

    1. Role of gene expression profiling in defining indeterminate thyroid nodules in addition to BRAF analysis

      Nicla Borrelli, Clara Ugolini, Riccardo Giannini, Alessandro Antonelli, Mirella Giordano, Elisa Sensi, Liborio Torregrossa, Poupak Fallahi, Paolo Miccoli and Fulvio Basolo

      Article first published online: 7 JAN 2016 | DOI: 10.1002/cncy.21681

      • image
      • image

      BRAF mutation analysis alone fails to increase diagnostic accuracy in cases of indeterminate TIR3 fine-needle aspiration. However, data suggest that the additional analysis of the expression of specific molecular markers could have possible utility as a diagnostic tool, although further evidence based on a large series of samples is needed before definitive conclusions can be drawn.

    2. Monocentric study of bile aspiration associated with biliary brushing performed during endoscopic retrograde cholangiopancreatography in 239 patients with symptomatic biliary stricture

      Michèle Fior-Gozlan, Diane Giovannini, Maud Rabeyrin, Anne Mc Leer-Florin, Marie-Hélène Laverrière and Philippe Bichard

      Article first published online: 23 DEC 2015 | DOI: 10.1002/cncy.21667

      • image
      • image
      • image
      • image
      • image
      • image

      Bile aspiration associated with brushing is a safe, simple, and inexpensive procedure during therapeutic endoscopic retrograde cholangiopancreatography. It significantly improves the sensitivity (81%) of cytology for cancer diagnosis, especially in patients with cholangiocarcinoma.

  6. Commentary

    1. The atypical urothelial cell category in the Paris System: Strengthening the Achilles' heel

      Fadi Brimo and Manon Auger

      Article first published online: 21 DEC 2015 | DOI: 10.1002/cncy.21668

      The category of atypical urothelial cell has to date been an equivocal diagnostic category, causing frustration to both cytopathologists and clinicians. The new Paris System for Reporting Urinary Cytology now offers well-defined criteria that will help to standardize this problematic category as well as gather meaningful, comparable follow-up data from diverse institutions.

  7. Original Articles

    1. Using “residual” FNA rinse and body fluid specimens for next-generation sequencing: An institutional experience

      Shuanzeng Wei, David Lieberman, Jennifer J. D. Morrissette, Zubair W. Baloch, David B. Roth and Cindy McGrath

      Article first published online: 18 DEC 2015 | DOI: 10.1002/cncy.21666

      • image

      Targeted next-generation sequencing can be performed on residual fine-needle aspiration rinse and body fluid specimens. This approach is particularly important when a paucicellular cell block or biopsy specimen is encountered.

  8. Commentary

    1. An emerging role for cytopathology in precision oncology

      Chantal Pauli, Loredana Puca, Juan Miguel Mosquera, Brian D. Robinson, Himisha Beltran, Mark A. Rubin and Rema A. Rao

      Article first published online: 7 DEC 2015 | DOI: 10.1002/cncy.21647

      • image
      • image
      • image
      • image
      • image
      • image

      Investigators at the Institute for Precision Medicine at Weill Cornell Medical College and New York-Presbyterian Hospital have developed a special program to grow patient-derived, 3-dimensional tumor organoids that can be used for targeted and high-throughput drug testing, tailoring standard-of-care treatment strategies, and as models to study drug resistance. Platforms for the characterization and validation of patient-derived 3-dimensional tumor organoids are described, and the role of cytology as a cost-effective and powerful quality-control measure is illustrated.

  9. Original Articles

    1. Optimizing the DNA yield for molecular analysis from cytologic preparations

      Sinchita Roy-Chowdhuri, Chi-Wan Chow, Mary K. Kane, Hui Yao, Ignacio I. Wistuba, Savitri Krishnamurthy, John Stewart and Gregg Staerkel

      Article first published online: 2 DEC 2015 | DOI: 10.1002/cncy.21664

      • image
      • image
      • image

      Optimizing the yield of DNA extracted from cytology specimens maximizes the chances of successful molecular testing. This study demonstrates that scraping is a better method for tissue extraction than cell lifting and that fully frosted slides yield less DNA than nonfrosted slides.

  10. Commentary

    1. Highlights for the cytology community from the 2015 American Thyroid Association clinical guidelines on the management of thyroid nodules and well-differentiated thyroid cancer

      Erik K. Alexander, William C. Faquin and Jeffrey F. Krane

      Article first published online: 30 NOV 2015 | DOI: 10.1002/cncy.21662

      The 2015 American Thyroid Association guidelines reinforce the central role of thyroid fine-needle aspiration in the management of patients with concerning thyroid nodules. Of particular note to the cytology community, the guidelines endorse: 1) nodule selection for fine-needle aspiration based on size and ultrasonographic risk stratification; 2) adoption of The Bethesda System for Reporting Thyroid Cytopathology; and 3) a role for molecular testing in the management of thyroid nodules with indeterminate cytology results.

  11. Review Articles

    1. Cervical cancer prevention in Australia: Planning for the future

      A. Marion Saville

      Article first published online: 30 NOV 2015 | DOI: 10.1002/cncy.21643

      • image
      • image

      The high coverage rate that has been achieved to date by the Australian government's human papillomavirus (HPV) vaccination programs has already led to profound reductions in the prevalence of biopsy-confirmed, high-grade abnormalities and of vaccine-preventable HPV types in Australia. The government has established a special committee to ensure that the success of their vaccination and screening programs will continue and that all Australian women, vaccinated and unvaccinated, will have access to a cervical screening program based on current evidence and best practices.

  12. Original Articles

    1. Cytomorphological features of blastic plasmacytoid dendritic cell neoplasm on FNA and cerebrospinal fluid cytology: A review of 6 cases

      Joana Ferreira, Maria Gabriela Gasparinho and Ricardo Fonseca

      Article first published online: 30 NOV 2015 | DOI: 10.1002/cncy.21645

      • image
      • image
      • image

      Blastic plasmacytoid dendritic cell neoplasm is a recently described entity with a specific phenotype and poor outcome. Cytology, in association with flow cytometry, is a reliable method with which to establish the diagnosis.

    2. Cytologic categorization of pancreatic neoplastic mucinous cysts with an assessment of the risk of malignancy: A retrospective study based on the Papanicolaou Society of Cytopathology guidelines

      Amber L. Smith, Fadi W. Abdul-Karim and Abha Goyal

      Article first published online: 30 NOV 2015 | DOI: 10.1002/cncy.21657

      • image
      • image

      This study retrospectively categorizes pancreatic neoplastic mucinous cysts according to the Papanicolaou Society of Cytopathology guidelines for reporting pancreaticobiliary cytology. The findings reveal that this categorization is accurate and is associated with an increasing risk of malignancy, and this can further aid in patient management and risk stratification.

    3. Triage of ASC-H: A meta-analysis of the accuracy of high-risk HPV testing and other markers to detect cervical precancer

      Lan Xu, Freija Verdoodt, Nicolas Wentzensen, Christine Bergeron and Marc Arbyn

      Article first published online: 30 NOV 2015 | DOI: 10.1002/cncy.21661

      • image
      • image
      • image
      • image

      Because of the high probability of precancer in patients with a diagnosis of atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion (ASC-H), the utility of triage is limited. The usual recommendation of referring women with ASC-H to colposcopy is not altered by a positive triage test, whatever test is used. A negative high-risk human papillomavirus DNA or p16INK4a test may allow repeat testing, but this recommendation will depend on local decision thresholds for referral.

  13. Commentary

    1. Detection and characterization of circulating tumor cells in lung cancer: Why and how?

      Véronique J. Hofman, Marius Ilie and Paul M. Hofman

      Article first published online: 20 NOV 2015 | DOI: 10.1002/cncy.21651

      • image
      • image

      Lung cancer is the leading cause of cancer death worldwide. It has a poor prognosis, with a survival rate of 15% after 5 years for all pTNM stages of disease. The poor prognosis is mainly due to the fact that diagnosis is made at a late inoperable stage. New approaches aimed at improving the quality and length of life among these patients are urgently needed. These advances are expected to come from noninvasive, predictive, and personalized new tests, recently referred to as “liquid biopsies,” which are used for diagnostic, prognostic, and theragnostic purposes.

  14. Original Articles

    1. Urine cytology in monitoring recurrence in urothelial carcinoma after radical cystectomy and urinary diversion

      Haiyan Chen, Lin Liu, Stefan E. Pambuccian, Güliz A. Barkan, Marcus L. Quek and Eva M. Wojcik

      Article first published online: 13 NOV 2015 | DOI: 10.1002/cncy.21650

      In the current study of 111 patients treated with radical cystectomy and urinary diversion, 11 of whom developed disease recurrence during a mean follow-up interval of 40.8 months, urine cytology demonstrated high sensitivity, specificity, and positive and negative predictive values (82%, 97%, 75%, and 98%, respectively) for the detection of urothelial carcinoma recurrence. Six of 28 patients with a diagnosis of atypical urothelial cells (21.4%) were eventually found to have recurrences of urothelial carcinoma.

  15. Commentary

    1. Salivary gland FNA: New markers and new opportunities for improved diagnosis

      Marc P. Pusztaszeri, Joaquín J. García and William C. Faquin

      Article first published online: 5 NOV 2015 | DOI: 10.1002/cncy.21649

      • image
      • image
      • image
      • image
      • image

      Salivary gland fine-needle aspiration represents 1 of the most challenging areas of cytopathology; however, the discovery of several novel and/or next-generation immunocytochemical and molecular markers for salivary gland tumors has resulted in greater diagnostic accuracy in cytologic diagnosis. In this commentary, recent advances in salivary gland cytopathology are reviewed with a focus on salivary gland tumors associated with gene rearrangements.

  16. Original Articles

    1. Adequacy in voided urine cytology specimens: The role of volume and a repeat void upon predictive values for high-grade urothelial carcinoma

      Christopher J. VandenBussche, Dorothy L. Rosenthal and Matthew T. Olson

      Article first published online: 2 NOV 2015 | DOI: 10.1002/cncy.21634

      • image
      • image
      • image

      Voided urine specimens vary widely in terms of volume and cellularity, and no consensus exists about the proper role for these variables in assessing specimen adequacy. This study demonstrates that volume is an important component in the evaluation of adequacy for voided urine cytology specimens and details a methodology for determining a cutoff volume below which voided urines may be artificially nonmalignant.

  17. Editorials

    1. You have free access to this content
      Enough Is enough: Adequacy of voided urine cytology

      Güliz A. Barkan

      Article first published online: 2 NOV 2015 | DOI: 10.1002/cncy.21635

      Because The Paris System for Reporting Urinary Cytology includes results that are categorized as unsatisfactory/nondiagnostic, definitions for this category are needed across all urinary specimens (voided, instrumented) and preparation types. The study herein by VandenBussche et al is the first attempt to tackle this adequacy issue in voided urine specimens, but it raises further questions that hopefully will be clarified by collaborative efforts of the cytopathology and urology community.

  18. Original Articles

    1. Branched-chain in situ hybridization for κ and λ light chains: A powerful ancillary technique for determining B-cell clonality in cytology samples

      Kshitij Arora, Ivan Chebib, Lawrence Zukerberg, Manoj Gandhi, Miguel Rivera, David Ting and Vikram Deshpande

      Article first published online: 2 NOV 2015 | DOI: 10.1002/cncy.21629

      • image
      • image
      • image
      • image
      • image
      • image
      • image
      • image

      The automated branched-chain RNA in situ hybridization platform is a robust platform that detects a clonal B-cell population in cytology material.

  19. Commentary

    1. Cervical cancer screening in Australia: Past and present

      Annabelle Farnsworth

      Article first published online: 29 OCT 2015 | DOI: 10.1002/cncy.21642

      Australia has had an organized screening program for the prevention of cervical cancer for over 20 years. It has been highly successful with a significant reduction in incidence and mortality from this disease. Recently Australia announced significant changes to its screening program introducing Primary HPV testing. The effect of these changes is far reaching and its success will depend on implementation.

  20. Original Articles

    1. Massively parallel DNA sequencing from routinely processed cytological smears

      Laure Piqueret-Stephan, Charles Marcaillou, Cécile Reyes, Aurélie Honoré, Mélanie Letexier, David Gentien, Nathalie Droin, Ludovic Lacroix, Jean-Yves Scoazec and Philippe Vielh

      Article first published online: 27 OCT 2015 | DOI: 10.1002/cncy.21639

      • image
      • image
      • image
      • image
      • image
      • image

      Already processed cytological smears are an alternative source of tumor DNA. Extracted DNA from cytological materials can be sequenced with targeted and whole-exome sequencing.

    2. FaceTime validation study: Low-cost streaming video for cytology adequacy assessment

      Shweta Agarwal, Lichao Zhao, Roy Zhang and Lewis Hassell

      Article first published online: 22 OCT 2015 | DOI: 10.1002/cncy.21636

      • image

      Low-cost, mobile adaptor devices attached to microscopes capable of streaming live videos will greatly enhance the efficiency of cytopathologists by saving them considerable time. Despite certain technical issues, such as occasional poor server connectivity, fitting smartphone adapters, and image focusing, the readily available iPhone FaceTime technology is cost effective and easy to use for assessing the adequacy of cytologic samples.

    3. Rapid onsite evaluation: A comparison of cytopathologist and pulmonologist performance

      Nikhil Meena, Susanne Jeffus, Nicole Massoll, Eric R. Siegel, Soheila Korourian, Chien Chen and Thaddeus Bartter

      Article first published online: 22 OCT 2015 | DOI: 10.1002/cncy.21637

      Procedural pulmonologists can effectively learn enough cytology to be able to make rapid onsite evaluation a collaborative process and to greatly increase the efficiency of the cytopathologist.

  21. Commentary

    1. Cytology nomenclature and 2015 World Health Organization classification of lung cancer

      Maureen F. Zakowski

      Article first published online: 13 OCT 2015 | DOI: 10.1002/cncy.21628

      The recommendations of the 2015 World Health Organization classification of lung tumors are examined and discussed in terms of cytologic diagnoses.

  22. Erratum

    1. You have free access to this content
  23. Original Articles

    1. Impact of reclassifying noninvasive follicular variant of papillary thyroid carcinoma on the risk of malignancy in The Bethesda System for Reporting Thyroid Cytopathology

      William C. Faquin, Lawrence Q. Wong, Amir H. Afrogheh, Syed Z. Ali, Justin A. Bishop, Massimo Bongiovanni, Marc P. Pusztaszeri, Christopher J. VandenBussche, Jolanta Gourmaud, Louis J. Vaickus and Zubair W. Baloch

      Article first published online: 12 OCT 2015 | DOI: 10.1002/cncy.21631

      • image
      • image
      • image

      The proposed histologic reclassification of noninvasive follicular variant of papillary thyroid carcinoma as something other than carcinoma will significantly affect the implied risk of malignancy for the indeterminate diagnostic categories in The Bethesda System for Reporting Thyroid Cytopathology.

    2. The clinical performance of primary HPV screening, primary HPV screening plus cytology cotesting, and cytology alone at a tertiary care hospital

      Jung-Woo Choi, Younghye Kim, Ju-Han Lee and Young-Sik Kim

      Article first published online: 12 OCT 2015 | DOI: 10.1002/cncy.21632

      • image
      • image

      Three algorithms for cervical cancer screening are compared in routine practice. The results demonstrate that primary human papillomavirus screening alone is similar in performance to combined primary human papillomavirus screening plus cytology for detecting cervical intraepithelial neoplasia grade 2 or worse.

    3. Endoscopic ultrasound–guided FNA and ProCore biopsy in sampling pancreatic and intra-abdominal masses

      Jessica Dwyer, Liron Pantanowitz, N. Paul Ohori, Reetesh K. Pai, Colleen Vrbin, Randall E. Brand and Sara E. Monaco

      Article first published online: 2 OCT 2015 | DOI: 10.1002/cncy.21623

      • image
      • image
      • image
      • image

      The use of ProCore fine-needle biopsy in the evaluation of a variety of solid intra-abdominal masses sampled via endoscopic ultrasound is described. Overall, in a subset of cases that are difficult to diagnose by fine-needle aspiration alone, ProCore fine-needle biopsy is associated with greater cellularity and hence more material for ancillary studies and is consequently associated with more satisfactory specimens in comparison with matched fine-needle aspiration samples.

    4. Two-tiered subdivision of atypia on urine cytology can improve patient follow-up and optimize the utility of UroVysion

      Ryan E. Glass, Constantinos Coutsouvelis, Silvat Sheikh-Fayyaz, Karen Chau, Lisa Rosen, Ryan Brenkert, Farah Slim, Fanya Epelbaum, Kasturi Das and Rubina S. Cocker

      Article first published online: 2 OCT 2015 | DOI: 10.1002/cncy.21630

      • image

      The use of a 2-tiered subdivision of atypical cytology specimens may represent a feasible strategy for reducing the number of patients who have an unhelpful atypical diagnosis, improving communication with clinicians, facilitating patient triage, better dictating the use of ancillary tests, and reducing the financial burden of 1 of the most expensive known malignancies.

    5. Has Afirma gene expression classifier testing refined the indeterminate thyroid category in cytology?

      Sung-Eun Yang, Peggy S. Sullivan, Jianhua Zhang, Rekha Govind, Mary R. Levin, Jian-Yu Rao and Neda A. Moatamed

      Article first published online: 30 SEP 2015 | DOI: 10.1002/cncy.21624

      • image
      • image

      The Afirma gene expression classifier is a molecular test for thyroid fine-needle aspiration specimens with an indeterminate cytologic diagnosis. Comparison of a single institution's characteristics before and after the introduction of the gene expression classifier test further defines implications for the test in patient care.

    6. Cytopathologic diagnosis of oncocytic type intraductal papillary mucinous neoplasm: Criteria and clinical implications of accurate diagnosis

      Michelle D. Reid, Christina R. Stallworth, Melinda M. Lewis, Gizem Akkas, Bahar Memis, Olca Basturk and Volkan Adsay

      Article first published online: 28 SEP 2015 | DOI: 10.1002/cncy.21627

      • image
      • image
      • image
      • image
      • image
      • image

      The cytologic features of oncocytic intraductal papillary mucinous neoplasms are classic and distinctive, and they are similar to those of their histologic counterparts. Failure to recognize these features on fine-needle aspiration may lead to delayed resection and overtreatment with neoadjuvant chemoradiation, which is typically ineffective in these neoplasms which, even if invasive, have a better overall prognosis than invasive pancreatic ductal adenocarcinoma.

    7. CD10, BCL6, and MUM1 expression in diffuse large B-cell lymphoma on FNA samples

      Immacolata Cozzolino, Valeria Varone, Marco Picardi, Carlo Baldi, Domenico Memoli, Giuseppe Ciancia, Carmine Selleri, Gaetano De Rosa, Antonio Vetrani and Pio Zeppa

      Article first published online: 28 SEP 2015 | DOI: 10.1002/cncy.21626

      • image
      • image
      • image
      • image

      The CD10-B-cell lymphoma 6 (BCL6)-multiple myeloma oncogene 1 (MUM1) immunocytochemical algorithm is reliable on cell blocks and conventional smears of fine-needle aspiration samples. The fine-needle aspiration subclassification of diffuse large B-cell lymphoma may provide additional prognostic information that might be useful when histological sample are not available.

VIEW

  1. 1 - 35

SEARCH

SEARCH BY CITATION