Cancer Cytopathology

Cover image for Vol. 122 Issue 11

Early View (Online Version of Record published before inclusion in an issue)

Edited By: Celeste N. Powers, MD, PhD

Impact Factor: 3.807

ISI Journal Citation Reports © Ranking: 2013: 15/76 (Pathology); 58/203 (Oncology)

Online ISSN: 1934-6638

Associated Title(s): Cancer, CA: A Cancer Journal for Clinicians


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  1. Original Articles

    1. Endoscopic ultrasound-guided pancreatic fine-needle aspiration: Potential pitfalls in one institution's experience of 1212 procedures

      Joseph P. Bergeron, Kyle D. Perry, Patricia M. Houser and Jack Yang

      Article first published online: 19 NOV 2014 | DOI: 10.1002/cncy.21497

      Endoscopic ultrasound-guided fine-needle aspiration is a valuable tool for the diagnosis of pancreatic lesions, especially solid malignant tumors. Pathologists should be aware of the pitfalls in the cytologic diagnosis of pancreatic lesions that may significantly change the clinical management of the patients.

  2. Cytopathology Help Desk

  3. Original Articles

    1. Accuracy and risk of malignancy for diagnostic categories in urine cytology at a large tertiary institution

      Karen Chau, Lisa Rosen, Constantinos Coutsouvelis, Maly Fenelus, Ryan Brenkert, Melissa Klein, Gary Stone, Stephen Raab, Mohamed Aziz and Rubina Cocker

      Article first published online: 11 NOV 2014 | DOI: 10.1002/cncy.21477

      Our study demonstrates an overall sensitivity and specificity of cytologic diagnoses comparable to those previously reported and slightly higher values for both low-grade urothelial carcinoma of the bladder and high-grade urothelial carcinoma of the upper tract. A higher value for additive sensitivity and a discrete time analysis showing a decline in predicted positive cytology after the fourth cytology suggests that the optimal follow-up should include at least 4 consecutive urine cytology specimens over a time period averaging 22.2 months.

    2. Fine-needle aspiration biopsy of secondary neoplasms of the thyroid gland: A multi-institutional study of 62 cases

      Marc Pusztaszeri, He Wang, Edmund S. Cibas, Celeste N. Powers, Massimo Bongiovanni, Syed Ali, Kamal K. Khurana, Paul J. Michaels and William C. Faquin

      Article first published online: 4 NOV 2014 | DOI: 10.1002/cncy.21494

      Adenocarcinomas from the kidney, lung, breast, and colon along with squamous cell carcinomas represent the majority of secondary neoplasms of the thyroid gland (SNTGs). Fine-needle aspiration biopsy is a sensitive and accurate method for diagnosing SNTGs; however, diagnostic difficulties can occur, and knowledge of clinical history and judicious application of ancillary studies can increase the sensitivity and accuracy of fine-needle aspiration biopsy for detecting SNTGs.

    3. Low interobserver agreement in cytology grading of mucinous pancreatic neoplasms

      Carlie S. Sigel, Marcia Edelweiss, Leung Chu Tong, Joanna Magda, Handy Oen, Keith M. Sigel and Maureen F. Zakowski

      Article first published online: 29 OCT 2014 | DOI: 10.1002/cncy.21492

      Observers showed fair interobserver agreement for grading mucinous pancreatic neoplasms and low interobserver agreement for identifying neoplastic mucin. Knowledge of the cyst fluid carcinoembryonic antigen level was found to modestly improve interobserver agreement for low-grade neoplasms.

    4. Follow-up and clinical significance of unsatisfactory liquid-based Papanicolaou tests

      Christopher L. Owens, Diana S.M. Buist, Daniel Peterson, Aruna Kamineni, Sheila Weinmann, Tyler Ross, Andrew E. Williams, Azadeh Stark, Kenneth F. Adams, Chyke A. Doubeni and Terry S. Field

      Article first published online: 23 OCT 2014 | DOI: 10.1002/cncy.21490

      Various clinical factors influence the receipt of guideline-recommended follow-up studies after an unsatisfactory Papanicolaou test. The results of high-risk human papillomavirus testing demonstrate promise for stratifying the risk after an unsatisfactory Papanicolaou test.

    5. A cytomorphometric analysis of pulmonary and mediastinal granulomas: Differentiating histoplasmosis from sarcoidosis by fine-needle aspiration

      Michael P. Gailey, Matthew E. Keeney and Chris S. Jensen

      Article first published online: 15 OCT 2014 | DOI: 10.1002/cncy.21491

      The majority of cases of histoplasmosis and sarcoidosis can be differentiated by several cytologic parameters, such as the presence of necrosis, the number of granulomas, the morphology of granulomas, and the presence of giant cell infiltrates.

  4. Cytopathology Help Desk

  5. Original Articles

    1. Influence of knowledge of human immunodeficiency virus serostatus on accuracy of cervical cytologic diagnosis

      Louis-Jacques van Bogaert

      Article first published online: 29 SEP 2014 | DOI: 10.1002/cncy.21487

      Women infected with the human immunodeficiency virus are at high risk of human papillomavirus-related preinvasive and invasive cervical lesions. Knowledge of a patient's human immunodeficiency virus serostatus may lead to cytologic overdiagnosis, resulting in unnecessary interventions.

  6. Commentary

    1. An historic step for advanced cytopathology training in Canada

      Manon Auger, Shahidul Islam and Michele Weir

      Article first published online: 23 SEP 2014 | DOI: 10.1002/cncy.21485

      Advanced cytopathology training has finally obtained official recognition in Canada, having recently been assigned the newly developed status of “Area of Focused Competence” by the Royal College of Physicians and Surgeons of Canada. It is hoped that the trainees who graduate from these programs in cytopathology will be provided with the leadership and consultant skills to allow them to adapt and respond competently to the rapid evolving field of cytopathology.

  7. Review Articles

    1. Cytopathology fellowship milestones

      Wesley Y. Naritoku and W. Stephen Black-Schaffer

      Article first published online: 18 SEP 2014 | DOI: 10.1002/cncy.21483

      There are 90 Accreditation Council for Graduate Medical Education-accredited cytopathology fellowship training programs in the United States, each with its own unique curriculum designed to achieve its goals and objectives. The Accreditation Council for Graduate Medical Education cytopathology fellowship milestones were developed to ensure some uniformity in the outcomes of the various skill sets and competencies expected of a graduating cytopathology fellow.

  8. Original Articles

    1. Multiplatform comparison of molecular oncology tests performed on cytology specimens and formalin-fixed, paraffin-embedded tissue

      Michael P. Gailey, Aaron A. Stence, Chris S. Jensen and Deqin Ma

      Article first published online: 3 SEP 2014 | DOI: 10.1002/cncy.21476

      Cytology specimens are a cost-effective, reliable source for molecular oncology testing and may save patients from additional procedures when adequate material is available.

    2. Outcome of patients with negative and unsatisfactory cytologic specimens obtained by endobronchial ultrasound-guided transbronchial fine-needle aspiration of mediastinal lymph nodes

      Hiren J. Mehta, Nichole T. Tanner, Gerard Silvestri, Suzanne M. Simkovich, Clayton Shamblin, Stephanie R. Shaftman, Paul J. Nietert and Jack Yang

      Article first published online: 3 SEP 2014 | DOI: 10.1002/cncy.21482

      The current study evaluated the outcome of patients with negative and unsatisfactory cytologic specimens obtained by endobronchial ultrasound-guided transbronchial fine-needle aspiration of mediastinal lymph nodes in patients with known or suspected lung cancer. The results demonstrated that the negative predictive values of lymph nodes with cytologic diagnoses of negative and unsatisfactory were 93.9% (95% confidence interval, 91.6%-96.3%) and 88.2% (95% confidence interval, 81.4%-95.1%), respectively.

    3. Morphological parameters able to predict BRAFV600E-mutated malignancies on thyroid fine-needle aspiration cytology: Our institutional experience

      Esther Diana Rossi, Tommaso Bizzarro, Maurizio Martini, Sara Capodimonti, Guido Fadda, Luigi Maria Larocca and Fernando Schmitt

      Article first published online: 25 AUG 2014 | DOI: 10.1002/cncy.21475

      The BRAFV600E mutation is a strong indicator of papillary thyroid carcinoma. Its evaluation is typically performed with DNA-based techniques; nonetheless, a few articles have recently proposed its morphological prediction. The detection of specific mutational cellular details on fine-needle aspiration cytology might be a valid alternative to DNA-based methods with reliable results.

    4. Interobserver reproducibility and accuracy of p16/Ki-67 dual-stain cytology in cervical cancer screening

      Nicolas Wentzensen, Barbara Fetterman, Diane Tokugawa, Mark Schiffman, Philip E. Castle, Shannon N. Wood, Eric Stiemerling, Nancy Poitras, Thomas Lorey and Walter Kinney

      Article first published online: 12 AUG 2014 | DOI: 10.1002/cncy.21473

      The authors evaluate the reproducibility and accuracy of p16/Ki-67 dual-stain cytology among 10 newly trained evaluators. The results indicate that the evaluation of p16/Ki-67 dual staining on cytology slides can be implemented in routine cytology practice with limited training and good to excellent reproducibility.

    5. Thyroid nodules with KRAS mutations are different from nodules with NRAS and HRAS mutations with regard to cytopathologic and histopathologic outcome characteristics

      Lisa A. Radkay, Simion I. Chiosea, Raja R. Seethala, Steven P. Hodak, Shane O. LeBeau, Linwah Yip, Kelly L. McCoy, Sally E. Carty, Karen E. Schoedel, Marina N. Nikiforova, Yuri E. Nikiforov and N. Paul Ohori

      Article first published online: 12 AUG 2014 | DOI: 10.1002/cncy.21474

      RAS mutations are found in approximately 20% to 45% of thyroid neoplasms and are associated with carcinoma in 74% to 87% of cases (most commonly follicular variant papillary thyroid carcinoma). In the current study, the authors report that subclassification of RAS mutations provides better insight into lesional characteristics. In particular, KRAS12/13-mutated thyroid nodules are associated with a lower carcinoma outcome (41.7%) and frequent oncocytic changes.

    6. Cytologic characterization of atypical teratoid/rhabdoid tumor in cerebrospinal fluid

      Eric C. Huang, Miguel A. Guzman, Umberto De Girolami and Edmund S. Cibas

      Article first published online: 4 AUG 2014 | DOI: 10.1002/cncy.21470

    7. The impact of atypia/follicular lesion of undetermined significance and repeat fine-needle aspiration: 5 years before and after implementation of the Bethesda System

      Peggy S. Sullivan, Sharon L. Hirschowitz, Po Chu Fung and Sophia K. Apple

      Article first published online: 30 JUL 2014 | DOI: 10.1002/cncy.21468

      In the current study, the authors observe an increase in the percentage of atypia or follicular lesion of undetermined significance (AUS/FLUS) cases and a decrease in nondiagnostic cases with implementation of the Bethesda System for Reporting Thyroid Cytopathology. They also note more repeat fine-needle aspirations in the management of an AUS/FLUS diagnosis and an elevated malignancy risk in benign and AUS/FLUS cases associated with another AUS/FLUS diagnosis.

    8. The usefulness of the cell transfer technique for immunocytochemistry of fine-needle aspirates

      Ann E. Marshall, Harvey M. Cramer and Howard H. Wu

      Article first published online: 30 JUL 2014 | DOI: 10.1002/cncy.21469

      In the authors' experience with performing immunocytochemistry through the cell transfer technique, a total of 118 of 11,259 fine-needle aspiration cases (1%) studied were found to demonstrate useful information that contributed to the final diagnosis.

    9. The role of SOX11 immunostaining in confirming the diagnosis of mantle cell lymphoma on fine-needle aspiration samples

      Y. Helen Zhang, Joe Liu, Marilyn Dawlett, Ming Guo, Xiaoping Sun and Yun Gong

      Article first published online: 23 JUL 2014 | DOI: 10.1002/cncy.21465

      SOX11 immunostaining on fine-needle aspiration samples is highly accurate for mantle cell lymphoma. The staining can be used as a reliable adjunct to confirm mantle cell lymphoma.

  9. Erratum

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