Cancer Cytopathology

Cover image for Vol. 123 Issue 4

Early View (Online Version of Record published before inclusion in an issue)

Edited By: Celeste N. Powers, MD, PhD

Impact Factor: 3.807

ISI Journal Citation Reports © Ranking: 2013: 15/76 (Pathology); 58/203 (Oncology)

Online ISSN: 1934-6638

Associated Title(s): Cancer, CA: A Cancer Journal for Clinicians


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  1. Correspondence

  2. Original Articles

    1. Non-16/18 high-risk HPV infection predicts disease persistence and progression in women with an initial interpretation of LSIL

      Yasmin A. Lyons, Aparna A. Kamat, Haijun Zhou, Dina R. Mody, Mary R. Schwartz, Christopher Hobday and Yimin Ge

      Article first published online: 22 APR 2015 | DOI: 10.1002/cncy.21549

      Non-16/18 high-risk human papillomavirus genotypes strongly predict persistent cervical lesions and progression to high-grade lesions in women with an initial cytology interpretation of a low-grade squamous intraepithelial lesion.

    2. Prospective evaluation of p16/Ki-67 dual-stained cytology for managing women with abnormal Papanicolaou cytology: PALMS study results

      Christine Bergeron, Hans Ikenberg, Mario Sideri, Karin Denton, Johannes Bogers, Dietmar Schmidt, Francisco Alameda, Thomas Keller, Susanne Rehm, Ruediger Ridder and for the PALMS Study Group

      Article first published online: 17 APR 2015 | DOI: 10.1002/cncy.21542

      Women with Papanicolaou cytology results of atypical squamous cells of undetermined significance or low-grade squamous intraepithelial lesion can be efficiently triaged using p16/Ki-67 dual-stained cytology. The results of this current large, prospective, pan-European screening trial (Primary ASC-US LSIL Marker Study [PALMS]) confirm the high positivity of dual-stained cytology for disease prediction, which may reduce the number of unnecessary colposcopy referrals.

  3. Clinician's Corner

  4. Original Articles

    1. You have full text access to this OnlineOpen article
      Comparison of cervical cancer screening results among 256,648 women in multiple clinical practices

      Amy J. Blatt, Ronald Kennedy, Ronald D. Luff, R. Marshall Austin and Douglas S. Rabin

      Article first published online: 10 APR 2015 | DOI: 10.1002/cncy.21544

      Cervical cancer screening using a cotest that includes both a human papillomavirus test and a Papanicolaou test, compared with human papillomavirus-only testing, is better for identifying cervical intraepithelial neoplasia 3 or more severe cervical biopsy results. The current results support cotesting for women ages 30 to 65 years as the most effective screening test for cervical cancer detection.

  5. Clinician's Corner

  6. Original Articles

    1. Solid tumor metastases to the pancreas diagnosed by FNA: A single-institution experience and review of the literature

      Amber L. Smith, Shelley I. Odronic, Bridgette S. Springer and Jordan P. Reynolds

      Article first published online: 30 MAR 2015 | DOI: 10.1002/cncy.21541

      Metastases to the pancreas may be successfully diagnosed with fine-needle aspiration. This article highlights a single-institution experience with 22 solid tumors metastasizing to the pancreas and provides a review of the literature.

    2. Multiplex sequencing for EZH2, CD79B, and MYD88 mutations using archival cytospin preparations from B-cell non-Hodgkin lymphoma aspirates previously tested for MYC rearrangement and IGH/BCL2 translocation

      Gilda da Cunha Santos, Mauro Ajaj Saieg, Hyang Mi Ko, William R. Geddie, Scott L. Boerner, Kenneth J. Craddock, Michael Crump and Denis Bailey

      Article first published online: 23 MAR 2015 | DOI: 10.1002/cncy.21535

      Cytospin preparations (CP) stored at −20°C for up to 6 years are a reliable source of high-quality genomic material for multiplex sequencing. Successful detection of EZH2 (Y641), CD79B (Y196), and MYD88 (L265) mutations can be achieved using material scraped from archival CP obtained from B-cell non-Hodgkin lymphoma aspirates of cases previously tested for MYC rearrangement and IGH/BCL2 translocation.

    3. Cytopathology of pulmonary adenocarcinoma with a single histological pattern using the proposed International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society (IASLC/ATS/ERS) classification

      Erika F. Rodriguez, Sanja Dacic, Liron Pantanowitz, Walid E. Khalbuss and Sara E. Monaco

      Article first published online: 18 MAR 2015 | DOI: 10.1002/cncy.21532

      The current study investigates the cytological features of lung adenocarcinoma subtypes proposed by the International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society (IASLC/ATS/ERS) from cases with histology showing a single pattern. The findings demonstrate that some architectural and nuclear features may be helpful in distinguishing the prognostically adverse solid pattern from other patterns.

  7. Review Article

    1. Intraoperative consultation on pediatric central nervous system tumors by squash cytology

      César R. Lacruz, Inmaculada Catalina-Fernández, Ricardo H. Bardales, José Pimentel, Dolores López-Presa and Javier Sáenz-Santamaría

      Article first published online: 12 MAR 2015 | DOI: 10.1002/cncy.21537

      In pediatric central nervous system tumors, squash cytology improves the diagnostic accuracy and protects tissue from freezing artifacts; its use is recommended in every case. A Romanowsky-stained preparation provides valuable information about the background features of the examined lesion and complements conventional hematoxylin and eosin and Papanicolaou staining methods.

  8. Erratum

    1. You have free access to this content
  9. Original Articles

    1. HNF1β and S100A1 are useful biomarkers for distinguishing renal oncocytoma and chromophobe renal cell carcinoma in FNA and core needle biopsies

      James R. Conner, Michelle S. Hirsch and Vickie Y. Jo

      Article first published online: 4 MAR 2015 | DOI: 10.1002/cncy.21530

      The distinction between renal oncocytoma and chromophobe renal cell carcinoma can be challenging, especially in fine-needle aspiration and core biopsies. Immunoreactivity for both HNF1β and S100A1 is present in a significantly greater proportion of oncocytomas than in chromophobe renal cell carcinomas, and these immunohistochemical markers may aid in the differential diagnosis.

    2. Microphthalmia transcription factor immunohistochemistry for FNA biopsy of ocular malignant melanoma

      Carmen M. Perrino, Jeff F. Wang and Brian T. Collins

      Article first published online: 24 FEB 2015 | DOI: 10.1002/cncy.21531

      This study is an evaluation of immunohistochemistry in the workup of fine-needle aspiration biopsies of ocular malignant melanoma and especially the new marker microphthalmia transcription factor. In addition, we show that microphthalmia transcription factor immunohistochemistry may be reliably performed on alcohol-fixed, Papanicolaou-stained direct smears.

    3. FNA, core biopsy, or both for the diagnosis of lung carcinoma: Obtaining sufficient tissue for a specific diagnosis and molecular testing

      Shana M. Coley, John P. Crapanzano and Anjali Saqi

      Article first published online: 24 FEB 2015 | DOI: 10.1002/cncy.21527

      Lung lesions are frequently sampled under computed tomography guidance. Fine-needle aspiration, core biopsy, and both are equivalent at providing tissue for histological, immunohistochemical, and molecular diagnoses.

  10. Clinician's Corner

  11. Original Articles

    1. Comprehensive mutation profiling by next-generation sequencing of effusion fluids from patients with high-grade serous ovarian carcinoma

      Ronak H. Shah, Sasinya N. Scott, A. Rose Brannon, Douglas A. Levine, Oscar Lin and Michael F. Berger

      Article first published online: 5 FEB 2015 | DOI: 10.1002/cncy.21522

      Cytology specimens represent suitable material for high-throughput sequencing. In this study, all mutations described by The Cancer Genome Atlas are independently identified in samples of effusion fluid.


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