Cancer Cytopathology

Cover image for Vol. 123 Issue 7

Early View (Online Version of Record published before inclusion in an issue)

Edited By: Celeste N. Powers, MD, PhD

Impact Factor: 3.737

ISI Journal Citation Reports © Ranking: 2014: 16/75 (Pathology); 81/211 (Oncology)

Online ISSN: 1934-6638

Associated Title(s): Cancer, CA: A Cancer Journal for Clinicians


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  1. Clinician's Corner

  2. Original Articles

    1. Factors affecting the success of next-generation sequencing in cytology specimens

      Sinchita Roy-Chowdhuri, Rashmi S. Goswami, Hui Chen, Keyur P. Patel, Mark J. Routbort, Rajesh R. Singh, Russell R. Broaddus, Bedia A. Barkoh, Jawad Manekia, Hui Yao, L. Jeffrey Medeiros, Gregg Staerkel, Rajyalakshmi Luthra and John Stewart

      Article first published online: 31 JUL 2015 | DOI: 10.1002/cncy.21597

      Next-generation sequencing in cytology specimens is often challenging because of the limited sample volume. The failure of next-generation sequencing is multifactorial, and identifying these pre-analytical variables will allow better selection of cytology material and increase the frequency of successful testing.

    2. HPV DNA testing with cytology triage in cervical cancer screening: Influence of revealing HPV infection status

      Lyndsay Ann Richardson, Mariam El-Zein, Agnihotram V. Ramanakumar, Samuel Ratnam, Ghislain Sangwa-Lugoma, Adhemar Longatto-Filho, Marly Augusto Cardoso, Francois Coutlée, Eduardo L. Franco and The PEACHS (Pap Efficacy After Cervical HPV Status) Study Consortium

      Article first published online: 31 JUL 2015 | DOI: 10.1002/cncy.21596

      In the current study, knowledge of human papillomavirus positivity by cytotechnicians results in a reduction in the diagnostic accuracy of Papanicolaou cytology, contrary to expectations. Findings from this study underscore the importance of maintaining meticulous quality control practices for cytology, even when serving as a triage test subsequent to primary human papillomavirus testing.

    3. Uncommon BRAF mutations in the follicular variant of thyroid papillary carcinoma: New insights

      Esther Diana Rossi, Maurizio Martini, Tommaso Bizzarro, Sara Capodimonti, Tonia Cenci, Celestino Pio Lombardi, Alfredo Pontecorvi, Guido Fadda and Luigi Maria Larocca

      Article first published online: 31 JUL 2015 | DOI: 10.1002/cncy.21586

      Mutational analysis is reshaping the practice of fine-needle aspiration cytology for the diagnosis of thyroid nodules. Although BRAF mutations are the most common in thyroid cancer, rare mutations have been described and are mainly associated with the follicular variant.

    4. Epidermal growth factor receptor mutation status in cell-free DNA supernatant of bronchial washings and brushings

      Akihiko Kawahara, Chihiro Fukumitsu, Tomoki Taira, Hideyuki Abe, Yorihiko Takase, Kazuya Murata, Tomohiko Yamaguchi, Koichi Azuma, Hidenobu Ishii, Shinzo Takamori, Jun Akiba, Tomoaki Hoshino and Masayoshi Kage

      Article first published online: 31 JUL 2015 | DOI: 10.1002/cncy.21583

      Activating epidermal growth factor receptor mutations can be detected with cytology cell-free DNA extracted from the supernatant fluid of liquid-based samples.

  3. Cytopathology Help Desk

    1. Cytopathology meets basic science

      Elena Vigliar, Umberto Malapelle and Giancarlo Troncone

      Article first published online: 20 JUL 2015 | DOI: 10.1002/cncy.21578

  4. Correspondence

    1. You have full text access to this OnlineOpen article
      Reply to comparison of cervical cancer screening results among 256,648 women in multiple clinical practices

      Douglas S. Rabin, Amy J. Blatt, Ronald Kennedy, Ronald D. Luff and R. Marshall Austin

      Article first published online: 15 JUL 2015 | DOI: 10.1002/cncy.21570

  5. Review Articles

    1. The Cell-CT 3-dimensional cell imaging technology platform enables the detection of lung cancer using the noninvasive LuCED sputum test

      Michael G. Meyer, Jon W. Hayenga, Thomas Neumann, Rahul Katdare, Chris Presley, David E. Steinhauer, Timothy M. Bell, Christy A. Lancaster and Alan C. Nelson

      Article first published online: 6 JUL 2015 | DOI: 10.1002/cncy.21576

      Detection of lung cancer by the LuCED test is based on high-resolution 3-dimensional imaging of cells from sputum using a new analytical device called Cell-CT. LuCED demonstrates the high-sensitivity detection of cancer cells with excellent specificity and has the potential to be used as a primary screener or used adjunctively with low-dose x-ray computed tomography.

  6. Original Articles

    1. Automated 3-dimensional morphologic analysis of sputum specimens for lung cancer detection: Performance characteristics support use in lung cancer screening

      David C. Wilbur, Michael G. Meyer, Chris Presley, Ralph W. Aye, Paul Zarogoulidis, Douglas W. Johnson, Nir Peled and Alan C. Nelson

      Article first published online: 6 JUL 2015 | DOI: 10.1002/cncy.21565

      Three-dimensional scanning of cells can be used to evaluate routinely obtained sputum specimens. Automated rare event analysis and increased morphologic discriminatory power combined with manual digital review demonstrates the potential to improve sensitivity and specificity to make lung cancer screening possible.

    2. Cytopathologic features of epithelioid inflammatory myofibroblastic sarcoma with correlation of histopathology, immunohistochemistry, and molecular cytogenetic analysis

      Jen-Chieh Lee, Jiann-Ming Wu, Jau-Yu Liau, Hsuan-Ying Huang, Cheng-Yu Lo, I-Shiow Jan, Jason L. Hornick and Xiaohua Qian

      Article first published online: 2 JUL 2015 | DOI: 10.1002/cncy.21558

      Epithelioid inflammatory myofibroblastic sarcoma is an aggressive variant of inflammatory myofibroblastic tumor. The cytologic features recapitulate its histologic characteristics. Diagnosis requires a high index of suspicion as well as confirmatory immunohistochemistry and molecular studies.

    3. Use of FTA cards for the storage of breast carcinoma nucleic acid on fine-needle aspiration samples

      Anna Lucia Peluso, Anna Maria Cascone, Lucrezia Lucchese, Immacolata Cozzolino, Antonio Ieni, Chiara Mignogna, Stefano Pepe and Pio Zeppa

      Article first published online: 29 JUN 2015 | DOI: 10.1002/cncy.21577

      The preservation and storage of nucleic acids is important for DNA molecular techniques, and therefore the material obtained by fine-needle aspiration needs to be emphasized. FTA cards can be conveniently used for the storage of breast carcinoma cells obtained by fine-needle aspiration, thereby providing a reliable alternative to traditional methods.

    4. Use of BRAF v600e immunocytochemistry on FNA direct smears of papillary thyroid carcinoma

      Sara E. Wobker, Lawrence T. Kim, Trevor G. Hackman and Leslie G. Dodd

      Article first published online: 16 JUN 2015 | DOI: 10.1002/cncy.21575

      The use of immunostaining with the anti-BRAF V600E antibody VE1 is possible on fine-needle aspirate direct smears. The staining process will require further optimization for routine use.

    5. Effective clinical practices for improved FNA biopsy cell block outcomes

      Brian T. Collins, Telly C. Garcia and Jena B. Hudson

      Article first published online: 16 JUN 2015 | DOI: 10.1002/cncy.21573

      At least 1 dedicated fine-needle aspiration (FNA) biopsy pass appears to improve cell block quality and the terminal FNA biopsy smear contributes significantly to obtaining a high-quality cell block. The performance of dedicated FNA biopsies and the use of high-quality aspirate smears are effective clinical practices with which to improve cell block outcomes.

  7. Commentary

    1. Comments on the recently published “Guidelines for the cytopathologic diagnosis of epithelioid and mixed-type malignant mesothelioma”

      Anders Hjerpe and Katalin Dobra

      Article first published online: 10 JUN 2015 | DOI: 10.1002/cncy.21563

      Recently published guidelines describe how a specific diagnosis based on effusions can be obtained in most patients with malignant mesothelioma. The high positive predictive value makes biopsy sampling redundant in these patients and allows an earlier diagnosis.

    2. US Food and Drug Administration regulatory oversight of laboratory-developed tests: Commentary on the draft guidance

      Mary K. Sidawy

      Article first published online: 4 JUN 2015 | DOI: 10.1002/cncy.21566

      In 1976, Congress introduced the Medical Device Amendments to regulate medical devices intended for use in humans. The definition of “device” encompasses diagnostic devices manufactured by manufacturers as well as laboratory-developed tests (LDTs). To ensure that LDTs are safe and effective, on October 3, 2014, the US Food and Drug Administration issued a draft document outlining a plan to enforce its authority. A second draft document outlines the laboratory requirements for reporting their LDTs and adverse events related to testing.

  8. Original Articles

    1. Digital gene expression profiling of a series of cytologically indeterminate thyroid nodules

      Riccardo Giannini, Liborio Torregrossa, Stefano Gottardi, Lorenzo Fregoli, Nicla Borrelli, Mauro Savino, Elisabetta Macerola, Paolo Vitti, Paolo Miccoli and Fulvio Basolo

      Article first published online: 29 MAY 2015 | DOI: 10.1002/cncy.21564

      Gene expression profiling may improve diagnostic accuracy in indeterminate fine-needle aspiration cytology samples. The current data suggest that preoperative gene expression profiling may be helpful in the classification of thyroid nodules.

  9. Help Desk

  10. Original Articles

    1. The impact of the new proposed Papanicolaou Society of Cytopathology terminology for pancreaticobiliary cytology in endoscopic US-FNA: A single-Institutional experience

      Mauro Ajaj Saieg, Valerie Munson, Shanna Colletti and Aziza Nassar

      Article first published online: 20 MAY 2015 | DOI: 10.1002/cncy.21559

      The application of the new proposed terminology for pancreaticobiliary cytology has a greater impact on specimens previously classified as atypical and suspicious. Its broad use may ultimately contribute to a more standardized therapy for patients with pancreatic disease.

  11. Review Articles

    1. Molecular markers: Implications for cytopathology and specimen collection

      Paul A. VanderLaan

      Article first published online: 11 MAY 2015 | DOI: 10.1002/cncy.21560

      In this era of personalized medicine, testing for a wide array of relevant molecular markers has become an increasingly important component in the diagnostic, prognostic, and therapeutic workup of cytology specimens. The recognition of these established and emerging molecular markers by cytopathologists is an important step toward realizing the promise of personalized medicine.

  12. Original Articles

    1. Poor cell block adequacy rate for molecular testing improved with the addition of Diff-Quik–stained smears: Need for better cell block processing

      Shuko Harada, Emmanuel Agosto-Arroyo, Jessica A. Levesque, Evan Alston, Karen M. Janowski, Gina M. Coshatt and Isam A. Eltoum

      Article first published online: 8 MAY 2015 | DOI: 10.1002/cncy.21561

      The objective of this study is to assess the frequency and types of samples deemed insufficient for lung cancer molecular testing (quantity not sufficient [QNS]). For cases rejected for the inadequacy of cell blocks of cytology specimens, air-dried, Diff-Quik–stained smears have been reviewed and used. The QNS rate for small biopsy specimens is 35.9% (28 of 78), whereas 64% (16 of 25) of cytology cases ordered on CBs are rejected. In combination with Diff-Quik–stained smears, the QNS rate for cytology specimens is 32% (8 of 25). The utilization of Diff-Quik–stained smears for molecular testing has improved the adequacy of cytologic samples, and it provides a minimally invasive alternative to surgical biopsy for molecular analysis.

    2. Malignant risk stratification of thyroid FNA specimens with indeterminate cytology based on molecular testing

      Svetlana Paskaš, Jelena Janković, Vladan Živaljević, Svetislav Tatić, Vesna Božić, Aleksandra Nikolić, Dragica Radojković, Svetlana Savin and Dubravka Cvejić

      Article first published online: 27 APR 2015 | DOI: 10.1002/cncy.21554

      Based on the BRAF V600E mutation status, galectin-3 protein expression, and microRNA-221/222 expression, a predictor model distinguishing benign fine-needle aspiration samples with indeterminate cytology from malignant ones has been developed.

  13. Erratum

    1. You have free access to this content


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