Cancer Cytopathology

Cover image for Vol. 123 Issue 5

Early View (Online Version of Record published before inclusion in an issue)

Edited By: Celeste N. Powers, MD, PhD

Impact Factor: 3.807

ISI Journal Citation Reports © Ranking: 2013: 15/76 (Pathology); 58/203 (Oncology)

Online ISSN: 1934-6638

Associated Title(s): Cancer, CA: A Cancer Journal for Clinicians


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  1. Original Articles

    1. Digital gene expression profiling of a series of cytologically indeterminate thyroid nodules

      Riccardo Giannini, Liborio Torregrossa, Stefano Gottardi, Lorenzo Fregoli, Nicla Borrelli, Mauro Savino, Elisabetta Macerola, Paolo Vitti, Paolo Miccoli and Fulvio Basolo

      Article first published online: 29 MAY 2015 | DOI: 10.1002/cncy.21564

      Gene expression profiling may improve diagnostic accuracy in indeterminate fine-needle aspiration cytology samples. The current data suggest that preoperative gene expression profiling may be helpful in the classification of thyroid nodules.

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  3. Original Articles

    1. The impact of the new proposed Papanicolaou Society of Cytopathology terminology for pancreaticobiliary cytology in endoscopic US-FNA: A single-Institutional experience

      Mauro Ajaj Saieg, Valerie Munson, Shanna Colletti and Aziza Nassar

      Article first published online: 20 MAY 2015 | DOI: 10.1002/cncy.21559

      The application of the new proposed terminology for pancreaticobiliary cytology has a greater impact on specimens previously classified as atypical and suspicious. Its broad use may ultimately contribute to a more standardized therapy for patients with pancreatic disease.

    2. Efficiency of EGFR mutation analysis for small microdissected cytological specimens using multitech DNA extraction solution

      Seo Young Oh and Hoon Taek Lee

      Article first published online: 11 MAY 2015 | DOI: 10.1002/cncy.21550

      The MultiTech DNA extraction solution is a reliable medium that improves the resolution of cell morphology during microdissection. The results of the current study indicate that it is particularly useful in epidermal growth factor receptor mutations of samples containing a small number of cells.

  4. Review Articles

    1. Molecular markers: Implications for cytopathology and specimen collection

      Paul A. VanderLaan

      Article first published online: 11 MAY 2015 | DOI: 10.1002/cncy.21560

      In this era of personalized medicine, testing for a wide array of relevant molecular markers has become an increasingly important component in the diagnostic, prognostic, and therapeutic workup of cytology specimens. The recognition of these established and emerging molecular markers by cytopathologists is an important step toward realizing the promise of personalized medicine.

  5. Original Articles

    1. Poor cell block adequacy rate for molecular testing improved with the addition of Diff-Quik–stained smears: Need for better cell block processing

      Shuko Harada, Emmanuel Agosto-Arroyo, Jessica A. Levesque, Evan Alston, Karen M. Janowski, Gina M. Coshatt and Isam A. Eltoum

      Article first published online: 8 MAY 2015 | DOI: 10.1002/cncy.21561

      The objective of this study is to assess the frequency and types of samples deemed insufficient for lung cancer molecular testing (quantity not sufficient [QNS]). For cases rejected for the inadequacy of cell blocks of cytology specimens, air-dried, Diff-Quik–stained smears have been reviewed and used. The QNS rate for small biopsy specimens is 35.9% (28 of 78), whereas 64% (16 of 25) of cytology cases ordered on CBs are rejected. In combination with Diff-Quik–stained smears, the QNS rate for cytology specimens is 32% (8 of 25). The utilization of Diff-Quik–stained smears for molecular testing has improved the adequacy of cytologic samples, and it provides a minimally invasive alternative to surgical biopsy for molecular analysis.

    2. History of high-risk HPV and Pap test results in a large cohort of patients with invasive cervical carcinoma: Experience from the largest women's hospital in China

      Xiang Tao, Christopher C. Griffith, Xiangrong Zhou, Zhiheng Wang, Yabin Yan, Zaibo Li and Chengquan Zhao

      Article first published online: 8 MAY 2015 | DOI: 10.1002/cncy.21545

      In the current study, the authors explore prior high-risk human papillomavirus and Papanicolaou testing within 1 year of the diagnosis of cervical cancer in the largest women's hospital in China. Both high-risk human papillomavirus testing and Papanicolaou cytology appear to have similar negative rates in this population and fewer women were found to have negative testing results with both testing modalities.

    3. Prior high-risk HPV testing and Pap test results for 427 invasive cervical cancers in China's largest CAP-certified laboratory

      Baowen Zheng, Zaibo Li, Christopher C. Griffith, Shanshan Yan, Congde Chen, Xiangdong Ding, Xiaoman Liang, Huaitao Yang and Chengquan Zhao

      Article first published online: 8 MAY 2015 | DOI: 10.1002/cncy.21557

      This large study from China investigates prior human papillomavirus and Papanicolaou test results for patients with invasive cervical carcinoma from a population of women without access to an established screening program. The data demonstrate a considerable prior high-risk human papillomavirus–negative rate and a lower prior Papanicolaou-negative rate for these patients.

    4. Rapid on-site evaluation of EBUS-TBNA specimens of lymph nodes: Comparative analysis and recommendations for standardization

      Susanne K. Jeffus, Amy K. Joiner, Eric R. Siegel, Nicole A. Massoll, Nikhil Meena, Chien Chen, Steven R. Post and Thaddeus Bartter

      Article first published online: 30 APR 2015 | DOI: 10.1002/cncy.21555

      There has been no widespread adoption of standardized criteria for rapid on-site evaluation reporting of specimens from endobronchial ultrasound-guided transbronchial needle aspiration. This study compares 2 published on-site adequacy schemes with an unstructured system currently used at the University of Arkansas for Medical Sciences, and it proposes modifications with the goal of moving toward a uniform intra- and inter-institutional system for rapid on-site evaluation reporting of endobronchial ultrasound-guided transbronchial needle aspiration.

    5. Molecular analysis of residual ThinPrep material from thyroid FNAs increases diagnostic sensitivity

      Jeffrey F. Krane, Edmund S. Cibas, Erik K. Alexander, Ralf Paschke and Markus Eszlinger

      Article first published online: 29 APR 2015 | DOI: 10.1002/cncy.21546

      Molecular analysis is feasible on residual ThinPrep fine-needle aspiration material of the thyroid with the advantage of not requiring the performance of additional fine-needle aspiration procedures. The usefulness of BRAF testing is limited by the low rate of BRAF mutations noted outside of the categories of “malignant” and “suspicious for malignancy.”

    6. Malignant risk stratification of thyroid FNA specimens with indeterminate cytology based on molecular testing

      Svetlana Paskaš, Jelena Janković, Vladan Živaljević, Svetislav Tatić, Vesna Božić, Aleksandra Nikolić, Dragica Radojković, Svetlana Savin and Dubravka Cvejić

      Article first published online: 27 APR 2015 | DOI: 10.1002/cncy.21554

      Based on the BRAF V600E mutation status, galectin-3 protein expression, and microRNA-221/222 expression, a predictor model distinguishing benign fine-needle aspiration samples with indeterminate cytology from malignant ones has been developed.

  6. Commentary

    1. Evolving role of FNA biopsy in diagnosing lymphoma: Past, present, and future

      Nancy P. Caraway

      Article first published online: 27 APR 2015 | DOI: 10.1002/cncy.21551

      Despite being challenged more than a decade ago, fine-needle aspiration biopsy continues to have a valuable role in diagnosing lymphomas. An updated lymphoma classification and several advances in technologies have aided in its increased acceptance and use; however, now is the time to integrate fine-needle aspiration biopsy with ancillary studies and obtain material for potential molecular testing in the routine workup of lymphomas to ensure its continued use in the future.

  7. Erratum

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  8. Correspondence

  9. Original Articles

    1. Non-16/18 high-risk HPV infection predicts disease persistence and progression in women with an initial interpretation of LSIL

      Yasmin A. Lyons, Aparna A. Kamat, Haijun Zhou, Dina R. Mody, Mary R. Schwartz, Christopher Hobday and Yimin Ge

      Article first published online: 22 APR 2015 | DOI: 10.1002/cncy.21549

      Non-16/18 high-risk human papillomavirus genotypes strongly predict persistent cervical lesions and progression to high-grade lesions in women with an initial cytology interpretation of a low-grade squamous intraepithelial lesion.

    2. Prospective evaluation of p16/Ki-67 dual-stained cytology for managing women with abnormal Papanicolaou cytology: PALMS study results

      Christine Bergeron, Hans Ikenberg, Mario Sideri, Karin Denton, Johannes Bogers, Dietmar Schmidt, Francisco Alameda, Thomas Keller, Susanne Rehm, Ruediger Ridder and for the PALMS Study Group

      Article first published online: 17 APR 2015 | DOI: 10.1002/cncy.21542

      Women with Papanicolaou cytology results of atypical squamous cells of undetermined significance or low-grade squamous intraepithelial lesion can be efficiently triaged using p16/Ki-67 dual-stained cytology. The results of this current large, prospective, pan-European screening trial (Primary ASC-US LSIL Marker Study [PALMS]) confirm the high positivity of dual-stained cytology for disease prediction, which may reduce the number of unnecessary colposcopy referrals.

  10. Clinician's Corner

  11. Original Articles

    1. Solid tumor metastases to the pancreas diagnosed by FNA: A single-institution experience and review of the literature

      Amber L. Smith, Shelley I. Odronic, Bridgette S. Springer and Jordan P. Reynolds

      Article first published online: 30 MAR 2015 | DOI: 10.1002/cncy.21541

      Metastases to the pancreas may be successfully diagnosed with fine-needle aspiration. This article highlights a single-institution experience with 22 solid tumors metastasizing to the pancreas and provides a review of the literature.

    2. Multiplex sequencing for EZH2, CD79B, and MYD88 mutations using archival cytospin preparations from B-cell non-Hodgkin lymphoma aspirates previously tested for MYC rearrangement and IGH/BCL2 translocation

      Gilda da Cunha Santos, Mauro Ajaj Saieg, Hyang Mi Ko, William R. Geddie, Scott L. Boerner, Kenneth J. Craddock, Michael Crump and Denis Bailey

      Article first published online: 23 MAR 2015 | DOI: 10.1002/cncy.21535

      Cytospin preparations (CP) stored at −20°C for up to 6 years are a reliable source of high-quality genomic material for multiplex sequencing. Successful detection of EZH2 (Y641), CD79B (Y196), and MYD88 (L265) mutations can be achieved using material scraped from archival CP obtained from B-cell non-Hodgkin lymphoma aspirates of cases previously tested for MYC rearrangement and IGH/BCL2 translocation.

  12. Review Article

    1. Intraoperative consultation on pediatric central nervous system tumors by squash cytology

      César R. Lacruz, Inmaculada Catalina-Fernández, Ricardo H. Bardales, José Pimentel, Dolores López-Presa and Javier Sáenz-Santamaría

      Article first published online: 12 MAR 2015 | DOI: 10.1002/cncy.21537

      In pediatric central nervous system tumors, squash cytology improves the diagnostic accuracy and protects tissue from freezing artifacts; its use is recommended in every case. A Romanowsky-stained preparation provides valuable information about the background features of the examined lesion and complements conventional hematoxylin and eosin and Papanicolaou staining methods.

  13. Erratum

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  14. Original Articles

    1. Microphthalmia transcription factor immunohistochemistry for FNA biopsy of ocular malignant melanoma

      Carmen M. Perrino, Jeff F. Wang and Brian T. Collins

      Article first published online: 24 FEB 2015 | DOI: 10.1002/cncy.21531

      This study is an evaluation of immunohistochemistry in the workup of fine-needle aspiration biopsies of ocular malignant melanoma and especially the new marker microphthalmia transcription factor. In addition, we show that microphthalmia transcription factor immunohistochemistry may be reliably performed on alcohol-fixed, Papanicolaou-stained direct smears.


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