Autism Research

Cover image for Vol. 9 Issue 8

Edited By: David G. Amaral, Ph.D

Online ISSN: 1939-3806

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  • Obsessive-Compulsive Disorder in Adults with High-Functioning Autism Spectrum Disorder: What Does Self-Report with the OCI-R Tell Us?

    Obsessive‐Compulsive Disorder in Adults with High‐Functioning Autism Spectrum Disorder: What Does Self‐Report with the OCI‐R Tell Us?

    OCI-R subscale scores for the control (n = 92), ASD-(n = 171), ASD + OCD (n = 54), and OCD (n = 108) groups.Note. Error bars represent 95% confidence intervals.

  • Atypical Face Perception in Autism: A Point of View?

    Atypical Face Perception in Autism: A Point of View?

    The four face-view conditions assessed in the present study; A: front-front; B: inverted; C: side-side; D: front-side (view-change condition).

  • 16p11.2 Deletion Syndrome Mice Display Sensory and Ultrasonic Vocalization Deficits During Social Interactions

    16p11.2 Deletion Syndrome Mice Display Sensory and Ultrasonic Vocalization Deficits During Social Interactions

    Reduced social sniffing in 16p11.2 +/− males in the three-phase male-female social interaction test. (A) Cohort 1 +/− males exhibited less anogenital sniffing and following, as compared to +/+ males, during the first male-female interaction session (Phase 1). (C) No genotype differences were detected during the second exposure to the female (Phase 3). (B and D) Cohort 2 +/− males exhibited less anogenital sniffing and less following than +/+ males in Phase 1, and less following in Phase 3. None of the individual social interaction parameter scores was significantly correlated with total numbers of USVs, indicating that social sniffing and vocalization are probably independent measures of response to social cues. Data are presented as mean ± standard error of the mean. *, P < 0.05 +/+ vs. +/−. See Supporting Information, Table S1 for statistical results of Figure .

  • Replication of Standardized ADOS Domain Scores in the Simons Simplex Collection

    Replication of Standardized ADOS Domain Scores in the Simons Simplex Collection

    a: (top, left) Distributions of raw SA domain totals by age/language cells. b: (top, right) c: Distributions of calibrated SA domain scores by age/language cells. (bottom, left) Distributions of raw restricted and repetitive behavior domain totals by age/language cells. d: (bottom, right) Distributions of calibrated restricted and repetitive behavior domain scores by age/language cells.

  • Meta-Analysis of Gene Expression in Autism Spectrum Disorder

    Meta‐Analysis of Gene Expression in Autism Spectrum Disorder

    Profiles of meta-analyses gene ranks from the blood and brain: raw P-values for each individual dataset are plotted against corrected P-values (FDR) from the meta-analyses. Local polynomial regression (LOESS) is used to obtain a smooth fit. The shaded areas represent 95% confidence intervals of the prediction using the t-based approximation (see “stat_smooth” in the ggplot2 R package).

  • Measuring social attention and motivation in autism spectrum disorder using eye-tracking: Stimulus type matters

    Measuring social attention and motivation in autism spectrum disorder using eye‐tracking: Stimulus type matters

    Representative stimuli for each task: (A) “Static Visual Exploration” task, (B) “Dynamic Visual Exploration” task, and (C) “Interactive Visual Exploration” task.

  • Pitt–Hopkins Mouse Model has Altered Particular Gastrointestinal Transits In Vivo

    Pitt–Hopkins Mouse Model has Altered Particular Gastrointestinal Transits In Vivo

    Particular in vivo gut transit velocities are reduced in PTHS mice. (A) Lengths of intestines. Total (left), small (center) and large (right) intestines were similar in length between the wt and PTHS animals. (B) Gastrointestinal (GI) transit velocities in vivo. Whole-gut transit velocity (left) was similar between the groups. Upper GI (center) and distal colon (right) transit velocities were significantly reduced in the PTHS mice.*P < 0.05, Student's t-test and Mann–Whitney U-test, respectively. Data are shown as mean ± SEM (left and center graphs) or as median ± IQR (right graphs). 18 wt and 16 PTHS mice were used for all the measurements except the upper GI transit. Three animals were excluded from the analysis of the upper GI transit, 1 in wt and 2 in PTHS groups, due to obvious distress signs after the gavage.

  • Obsessive‐Compulsive Disorder in Adults with High‐Functioning Autism Spectrum Disorder: What Does Self‐Report with the OCI‐R Tell Us?
  • Atypical Face Perception in Autism: A Point of View?
  • 16p11.2 Deletion Syndrome Mice Display Sensory and Ultrasonic Vocalization Deficits During Social Interactions
  • Replication of Standardized ADOS Domain Scores in the Simons Simplex Collection
  • Meta‐Analysis of Gene Expression in Autism Spectrum Disorder
  • Measuring social attention and motivation in autism spectrum disorder using eye‐tracking: Stimulus type matters
  • Pitt–Hopkins Mouse Model has Altered Particular Gastrointestinal Transits In Vivo

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