Preparation and characterization of the ‘research chemical’ diphenidine, its pyrrolidine analogue, and their 2,2-diphenylethyl isomers
Jason Wallach, Pierce V. Kavanagh, Gavin McLaughlin, Noreen Morris, John D. Power, Simon P. Elliott, Marion S. Mercier, David Lodge, Hamilton Morris, Nicola M. Dempster and Simon D. Brandt
Article first published online: 15 JUL 2014 | DOI: 10.1002/dta.1689
Diphenidine has recently appeared as a ‘research chemical’ and belongs to a range of 1,2-diarylethylamines suspected to show dissociative properties. This study presents the synthesis and in-depth characterization of diphenidine, its 2,2-diphenethyl isomer and their pyrrolidine analogues. Analysis of two samples obtained from an Internet vendor provided confirmation that diphenidine was present in both samples. An electrophysiological investigation with rat hippocampal slices also showed that diphenidine reduced N-methyl-D-aspartate (NMDA)-mediated field excitatory postsynaptic potentials similar to ketamine.