Cancer Medicine

Cover image for Vol. 5 Issue 4

Early View (Online Version of Record published before inclusion in an issue)

Edited By: Qingyi Wei, M.D., Ph.D.

Impact Factor: 2.5

ISI Journal Citation Reports © Ranking: 2014: 121/211 (Oncology)

Online ISSN: 2045-7634

VIEW

  1. 1 - 88
  1. Original Research

    1. You have full text access to this OnlineOpen article
      Lack of health maintenance examinations and risk in myeloma patients

      Joseph D. Tariman, Charise Gleason, Beth Faiman, Deborah Doss, Donna Catamero, Jessica Bishop-Royse, Mike Katz, Sandra Kurtin, Diane Moran, The IMF Nurse Leadership Board and Sagar Lonial

      Article first published online: 27 APR 2016 | DOI: 10.1002/cam4.716

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      Patients with MM, particularly men, require continued education and close monitoring of health maintenance practices. Healthcare providers must incorporate health maintenance promotion during routine clinic visits.

    2. You have full text access to this OnlineOpen article
      Real-world treatment practice in patients with advanced melanoma in the era before ipilimumab: results from the IMAGE study

      Mark R. Middleton, Stéphane Dalle, Joel Claveau, Pilar Mut, Sigrun Hallmeyer, Patrice Plantin, Martin Highley, Srividya Kotapati, Trong Kim Le, Jane Brokaw and Amy P. Abernethy

      Article first published online: 26 APR 2016 | DOI: 10.1002/cam4.717

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      The IMAGE (ipilimumab: management of advanced melanoma in real practice; ClinicalTrials.gov Identifier: NCT01511913) study is a multi-site, observational study evaluating real-world treatment and patient outcomes for advanced melanoma, both prospectively and retrospectively. Results from the retrospective cohort, which was treated in the era before the immuno-oncology agent ipilimumab, confirm the previous unmet need in advanced melanoma and provide historical information to facilitate the assessment of recent treatment patterns and trends in advanced melanoma.

    3. You have full text access to this OnlineOpen article
      Retrospective analysis of bevacizumab-induced hypertension and clinical outcome in patients with colorectal cancer and lung cancer

      Aya Nakaya, Takayasu Kurata, Takashi Yokoi, Shigeyoshi Iwamoto, Yoshitaro Torii, Yuichi Katashiba, Makoto Ogata, Madoka Hamada, Masanori Kon and Shosaku Nomura

      Article first published online: 25 APR 2016 | DOI: 10.1002/cam4.701

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      The most common bevacizumab-related adverse event was hypertension. Patients who developed hypertension during treatment with bevacizumab for colorectal cancer and non-small lung cancer had significantly prolonged overall survival.

    4. You have full text access to this OnlineOpen article
      Flow cytometry-based characterization of underlying clonal B and plasma cells in patients with light chain amyloidosis

      Katharina Lisenko, Stefan O. Schönland, Anna Jauch, Mindaugas Andrulis, Christoph Röcken, Anthony D. Ho, Hartmut Goldschmidt, Ute Hegenbart and Michael Hundemer

      Article first published online: 25 APR 2016 | DOI: 10.1002/cam4.725

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      Systemic amyloid light chain (AL) amyloidosis is a life-threatening protein deposition disorder and an accurate diagnosis of the underlying hematologic disease is important to provide effective therapy. We analyzed the presence of clonal plasma cell (PC) and B cells in the bone marrow of 63 patients with newly diagnosed AL-amyloidosis by multi-parameter flow cytometry (MFC). MFC identified underlying clonal lymphatic cells in all but two patients (61 of 63, 97%). Sixty-one patients harbored malignant PCs, whereas B-cell lymphomas were identified in two patients. These results demonstrate that MFC is a reliable tool for an accurate diagnosis of the underlying hematologic disease in patients with AL amyloidosis.

    5. You have full text access to this OnlineOpen article
      Adherence to cancer screening guidelines in Australian survivors of allogeneic blood and marrow transplantation (BMT)

      Gemma Dyer, Stephen R. Larsen, Nicole Gilroy, Lisa Brice, Matt Greenwood, Mark Hertzberg, Masura Kabir, Louisa Brown, Megan Hogg, Gillian Huang, John Moore, David Gottlieb, John Kwan, Jeff Tan, Christopher Ward and Ian Kerridge

      Article first published online: 25 APR 2016 | DOI: 10.1002/cam4.729

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      We conducted a cross-sectional survey of 441 Blood and Marrow Transplant (BMT) survivors who were >1 year post transplant, to explore rates of screening for secondary cancers and to identify barriers to adherence with cancer screening recommendations. Rates of cancer screening uptake were as follows: cervical 63.4%, breast 53.3%, skin 52.4%, and bowel 32.3%. Improved quality of life was associated with screening for skin, breast, and cervical cancer. Fear of cancer recurrence negatively impacted on cervical screening. For those who had not undergone screening, the majority reported not being advised to do so by their treatment team.

    6. You have full text access to this OnlineOpen article
      Are parenting behaviors associated with child sleep problems during treatment for acute lymphoblastic leukemia?

      Maria C. McCarthy, Jessica Bastiani and Lauren K. Williams

      Article first published online: 25 APR 2016 | DOI: 10.1002/cam4.727

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      This study examined sleep problems in children undergoing treatment for acute lymphoblastic leukemia (ALL) compared to healthy children and whether parenting practices are associated with sleep difficulties. Parents of children with ALL reported significantly more child sleep problems and parent–child co-sleeping was significantly associated with child sleep difficulties. Strategies employed by parents during ALL treatment may be a potential modifiable intervention target that could result in improved child quality of life.

    7. You have full text access to this OnlineOpen article
      Circulating CD14+HLA-DR-/low myeloid-derived suppressor cells in leukemia patients with allogeneic hematopoietic stem cell transplantation: novel clinical potential strategies for the prevention and cellular therapy of graft-versus-host disease

      Jin Yin, Chunyan Wang, Min Huang, Xia Mao, Jianfeng Zhou and Yicheng Zhang

      Article first published online: 25 APR 2016 | DOI: 10.1002/cam4.688

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      This study revealed that MDSCs might be considered as a novel prognostic factor in patients with allo-HSCT and potential new approaches to regulate transplant rejection and achieve the recipient host long-term acceptance and survival. The understanding of the activation and differentiation of MDSCs in human will help to develop inhibitors during their unwanted activity, such as preventing relapse, but also provide options for therapeutical intervention in aGVHD after allo-HSCT.

    8. You have full text access to this OnlineOpen article
      Prognostic microRNA signatures derived from The Cancer Genome Atlas for head and neck squamous cell carcinomas

      Nathan Wong, Shariq S. Khwaja, Callie M. Baker, Hiram A. Gay, Wade L. Thorstad, Mackenzie D. Daly, James S. Lewis Jr and Xiaowei Wang

      Article first published online: 25 APR 2016 | DOI: 10.1002/cam4.718

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      Prognostic microRNA signatures were identified for head and neck cancers by analysis of public profiling data from The Cancer Genome Atlas (TCGA). This work demonstrates the power of using TCGA as a potential resource to develop prognostic tools for improving individualized patient care.

    9. You have full text access to this OnlineOpen article
      Phase II evaluation of sunitinib in the treatment of recurrent or refractory high-grade glioma or ependymoma in children: a children's Oncology Group Study ACNS1021

      Cynthia Wetmore, Vinay M. Daryani, Catherine A. Billups, James M. Boyett, Sarah Leary, Rachel Tanos, Kelly C. Goldsmith, Clinton F. Stewart, Susan M. Blaney and Amar Gajjar

      Article first published online: 25 APR 2016 | DOI: 10.1002/cam4.713

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      This Phase II study of sunitinib reports the safety, tolerability and pharmacokinetic disposition in pediatric patients with recurrent high-grade glioma and ependymoma. While there was sufficient level of sunitinib in peripheral blood to modulate plasma vascular endothelial growth factor receptor (VEGFR)2, there were no sustained responses and no single agent activity in this patient cohort.

    10. You have full text access to this OnlineOpen article
      Breast cancer screening disparities among immigrant women by world region of origin: a population-based study in Ontario, Canada

      Mandana Vahabi, Aisha Lofters, Matthew Kumar and Richard H. Glazier

      Article first published online: 22 APR 2016 | DOI: 10.1002/cam4.700

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      The study found differences in rates of breast cancer screening among Ontario immigrant women by world region of origin. South Asian women had the lowest cancer screening rates. Factors associated with lower screening included living in the lowest income neighborhoods, having a refugee status, being a new immigrant, not having a regular physical examination, not being enrolled in a primary care patient enrollment model, having a male physician, and having an internationally trained physician.

    11. You have full text access to this OnlineOpen article
      Subsequent primary malignancies and acute myelogenous leukemia transformation among myelodysplastic syndrome patients treated with or without lenalidomide

      Dana E. Rollison, Kenneth H. Shain, Ji-Hyun Lee, Shalaka S. Hampras, William Fulp, Kate Fisher, Najla H. Al Ali, Eric Padron, Jeffrey Lancet, Qiang Xu, Martha Olesnyckyj, Laurie Kenvin, Robert Knight, William Dalton, Alan List and Rami S. Komrokji

      Article first published online: 20 APR 2016 | DOI: 10.1002/cam4.721

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      In a retrospective cohort study of myelodysplastic syndrome (MDS) patients (n = 1248), conducted at Moffitt Cancer Center, lenalidomide was not associated with subsequent primary malignancies (SPMs) incidence in the MDS cohort (HR = 1.04, 95% CI = 0.40–2.74), whereas a significantly reduced SPM risk was observed in the case–control sample (OR = 0.03, 95% CI = <0.01–0.63). Lenalidomide was not associated with acute myeloid leukemia (AML) transformation in the cohort analysis (HR = 0.75, 95% CI = 0.44–1.27) or in the case–control analyses (OR = 1.16, 95% CI = 0.52–2.56), after adjustment for potential confounders. In conclusion, lenalidomide was not associated with increased risk of SPM or AML transformation in a large cohort of MDS patients mostly including nondeletion 5q MDS.

    12. You have full text access to this OnlineOpen article
      HuR-regulated lncRNA NEAT1 stability in tumorigenesis and progression of ovarian cancer

      Yiqing Chai, Jie Liu, Zhikun Zhang and Liwei Liu

      Article first published online: 14 APR 2016 | DOI: 10.1002/cam4.710

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      LncRNA NEAT1, whose expression was collaboratively controlled by HuR and miR-124-3p, could regulate ovarian carcinogenesis and may serve as a potential target for antineoplastic therapies.

    13. You have full text access to this OnlineOpen article
      A phase I study of the human anti-activin receptor-like kinase 1 antibody PF-03446962 in Asian patients with advanced solid tumors

      Toshihiko Doi, Kyung-Hun Lee, Tae-Min Kim, Atsushi Ohtsu, Tae Yong Kim, Masafumi Ikeda, Kiyotaka Yoh, Corrado Gallo Stampino, Tomoko Hirohashi, Akiyuki Suzuki, Yosuke Fujii, James Andrew Williams and Yung-Jue Bang

      Article first published online: 14 APR 2016 | DOI: 10.1002/cam4.724

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      This report presents the safety, preliminary activity, and pharmacokinetics results of the first study of the novel anti-activin receptor-like kinase 1 (ALK-1) monoclonal antibody PF-03446962 in Asian patients with advanced solid tumors. The study findings suggest that activin receptor-like kinase-1 (ALK-1) inhibition by PF-03446962 may represent a novel antiangiogenic strategy for patients with advanced solid malignancies, complementary to vascular endothelial growth factor (receptor)-targeted therapy or chemotherapy.

    14. You have full text access to this OnlineOpen article
      Hepatitis B virus mutations, expression quantitative trait loci for PTPN12, and their interactions in hepatocellular carcinoma

      Ci Song, Yao Liu, Lu Xu, Juan Wen, Deke Jiang, Jianguo Chen, Xiangjun Zhai, Zhibin Hu, Li Liu and Jibin Liu

      Article first published online: 14 APR 2016 | DOI: 10.1002/cam4.712

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      PTPN12 may influence HCC risk accompanied by HBV mutations.

  2. Commentary

    1. You have full text access to this OnlineOpen article
      Moving survivorship care plans forward: focus on care coordination

      Talya Salz and Shrujal Baxi

      Article first published online: 14 APR 2016 | DOI: 10.1002/cam4.733

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      Five randomized controlled trials of the effectiveness of survivorship care plans have yielded null results. We propose that these trials failed to account for whether survivorship care plans improved the critical outcome of care coordination, and we propose four criteria for future studies that will improve the quality of the evidence base.

  3. Original Research

    1. You have full text access to this OnlineOpen article
      Organotypic slice cultures of human gastric and esophagogastric junction cancer

      Justus Koerfer, Sonja Kallendrusch, Felicitas Merz, Christian Wittekind, Christoph Kubick, Woubet T. Kassahun, Guido Schumacher, Christian Moebius, Nikolaus Gaßler, Nikolas Schopow, Daniela Geister, Volker Wiechmann, Arved Weimann, Christian Eckmann, Achim Aigner, Ingo Bechmann and Florian Lordick

      Article first published online: 12 APR 2016 | DOI: 10.1002/cam4.720

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      Gastric and esophagogastric junction cancer was cultured in slices ex vivo. Slice cultures revealed a good morphological preservation up to 6 days and tumor cellularity decreased significantly following cytotoxic treatment in vitro. Individual response to chemotherapy can be observed in human tumor slices cultures.

    2. You have full text access to this OnlineOpen article
      AKT1 and BRAF mutations in pediatric aggressive fibromatosis

      Cristina Meazza, Antonino Belfiore, Adele Busico, Giulio Settanni, Nicholas Paielli, Luca Cesana, Andrea Ferrari, Stefano Chiaravalli, Maura Massimino, Alessandro Gronchi, Chiara Colombo, Silvana Pilotti and Federica Perrone

      Article first published online: 8 APR 2016 | DOI: 10.1002/cam4.669

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      The aim of this study was to shed more light on the mutational spectrum of 28 pediatric aggressive fibromatosis (AF), comparing it with its adult counterpart. In addition to CTNNB1 mutation (64%), pediatric AF showed AKT1 (31%), BRAF (19%), and TP53 (9%) mutations, whereas only the CTNNB1 mutation was found in 33 adult AF. This intriguing finding, suggesting a mutational spectrum of pediatric AF more complex than that of adult, may have clinical implications and warrants further investigations.

    3. You have full text access to this OnlineOpen article
      Intraoperative frozen section analysis of the proximal bile ducts in hilar cholangiocarcinoma is of limited value

      Hendrik T.J. Mantel, Andrie C. Westerkamp, Egbert Sieders, Paul M. J. G. Peeters, Koert P. de Jong, Marieke T. Boer, Ruben H. de Kleine, Annette S. H. Gouw and Robert J. Porte

      Article first published online: 6 APR 2016 | DOI: 10.1002/cam4.693

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      The use of intraoperative frozen section analysis of the proximal bile duct in hilar cholangiocarcinoma is of limited clinical value because of the relatively low sensitivity, high risk of false-negative results, and the low rate of secondary obtained tumor-free resection margins. The technique should be reserved for those cases only in which a substantial additional resection is possible.

    4. You have full text access to this OnlineOpen article
      CD8+ tumor-infiltrating lymphocytes contribute to spontaneous “healing” in HER2-positive ductal carcinoma in situ

      Michi Morita, Rin Yamaguchi, Maki Tanaka, Gary M. Tse, Miki Yamaguchi, Naoki Kanomata, Yoshiki Naito, Jun Akiba, Satoshi Hattori, Shigeki Minami, Susumu Eguchi and Hirohisa Yano

      Article first published online: 6 APR 2016 | DOI: 10.1002/cam4.715

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      We evaluated the spontaneous “healing” phenomenon in ductal carcinoma in situ (DCIS) and its association with tumor-infiltrating lymphocytes (TIL) including CD8 positive lymphocytes. Spontaneous “healing” may be attributable to CD8+ high-TIL associated with high -grade, comedo necrosis, apocrine features, and HER2-positive DCIS.

    5. You have full text access to this OnlineOpen article
      Regulation of multidrug resistance 1 expression by CDX2 in ovarian mucinous adenocarcinoma

      Iemasa Koh, Takao Hinoi, Kazuhiro Sentani, Eiji Hirata, Suguru Nosaka, Hiroaki Niitsu, Masashi Miguchi, Tomohiro Adachi, Wataru Yasui, Hideki Ohdan and Yoshiki Kudo

      Article first published online: 6 APR 2016 | DOI: 10.1002/cam4.697

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      Resistance against chemotherapeutic agents often develops in ovarian cancer patients, contributing to high recurrence rates. We hypothesized that profiling of CDX2 and MDR1 expression could be an effective strategy for predicting anticancer drug resistance. Here, we demonstrate that CDX2 promotes upregulation of MDR1 expression leading to drug resistance in ovarian mucinous adenocarcinoma. Our findings have direct clinical implications regarding the development of novel therapeutic strategies for ovarian cancer based on CDX2 status.

    6. You have full text access to this OnlineOpen article
      Dermal fibroblasts induce cell cycle arrest and block epithelial–mesenchymal transition to inhibit the early stage melanoma development

      Linli Zhou, Kun Yang, R. Randall Wickett and Yuhang Zhang

      Article first published online: 6 APR 2016 | DOI: 10.1002/cam4.707

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      We developed a novel genetic approach to deactivate stromal fibroblasts in vivo to determine their role and functions at the onset of melanoma formation. Our findings clearly suggest that dermal fibroblasts defend against melanoma during early stages of tumor formation by inducing a cell cycle arrest, partially through MAPK/ERK and pRB pathways, and blocking epithelial-mesenchymal transition in melanoma cells.

    7. You have full text access to this OnlineOpen article
      Elevated microsatellite alterations at selected tetranucleotides in early-stage colorectal cancers with and without high-frequency microsatellite instability: same, same but different?

      Martin M. Watson, Dordi Lea, Emma Rewcastle, Hanne R. Hagland and Kjetil Søreide

      Article first published online: 6 APR 2016 | DOI: 10.1002/cam4.709

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      Elevated microsatellite alterations at selected tetranucleotides (EMAST) is a form of microsatellite instability that occurs in up to a quarter of colorectal cancers without traditional microsatellite instability (MSI). Presence of EMAST was not prognostic in this cohort of early colorectal cancer (CRC). A trend toward reduced cancer-specific survival was found for stage II colon cancers with EMAST.

    8. You have full text access to this OnlineOpen article
      GABABR/GSK-3β/NF-κB signaling pathway regulates the proliferation of colorectal cancer cells

      Qing Shu, Jun Liu, Xiupeng Liu, Sufang Zhao, Hualin Li, Yonggang Tan and Jianming Xu

      Article first published online: 5 APR 2016 | DOI: 10.1002/cam4.686

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      Activation of γ-Aminobutyric acid receptor (GABABR) signaling significantly inhibited the colorectal cell HT29 proliferation by arresting the cell at G1 phase. Inhibition of GABABR could activate GSK-3β by reducing the phosphorylation level of GSK-3β, moreover, activation of GSK-3β blocked the repression of cell proliferation caused by inhibition of GABABR signaling. Activation of GABABR leaded to inhibition of GSK-3β activation to repress the NF-κB function during colorectal cancer cell proliferation.

  4. Short Reports

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      AGK-BRAF gene fusion is a recurrent event in sporadic pediatric thyroid carcinoma

      Maria Isabel C. V. Cordioli, Lais Moraes, Gianna Carvalheira, Luiza Sisdelli, Maria Teresa S. Alves, Rosana Delcelo, Osmar Monte, Carlos A. Longui, Adriano N. Cury and Janete M. Cerutti

      Article first published online: 31 MAR 2016 | DOI: 10.1002/cam4.698

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      This study described, for the first time, the presence of AGK-BRAF in sporadic pediatric PTC. Understanding the molecular events underlying pediatric PTC may improve preoperative diagnosis, allow molecular prognostication and define a therapeutic approach toward sporadic PTC patients.

  5. Commentary

    1. You have full text access to this OnlineOpen article
      The real role of pseudokinase: linking diabetes to cancers

      Ke Li and Zhuowei Hu

      Article first published online: 31 MAR 2016 | DOI: 10.1002/cam4.706

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      Pseudokinase TRIB3 has a critical role in the development of diabetes-related cancers via interacting with SQSTM1, a selective autophagy receptor. Interrupting the TRIB3-SQSTM1 interaction, using an α-helix peptide shows a significant antitumor effect both in normal and diabetic mice.

  6. Short Reports

    1. You have full text access to this OnlineOpen article
      Can metronomic maintenance with weekly vinblastine prevent early relapse/progression after bevacizumab–irinotecan in children with low-grade glioma?

      Marie Amélie Heng, Laetitia Padovani, Philippe Dory-Lautrec, Jean Claude Gentet, Arnaud Verschuur, Eddy Pasquier, Dominique Figarella-Branger, Didier Scavarda and Nicolas André

      Article first published online: 31 MAR 2016 | DOI: 10.1002/cam4.699

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      Metronomic maintenance with vinblastine after irinotecan–bevacizumab induction may prevent relapse in children with low-grade glioma.

  7. Original Research

    1. You have full text access to this OnlineOpen article
      ADH1B and ALDH2 are associated with metachronous SCC after endoscopic submucosal dissection of esophageal squamous cell carcinoma

      Kenichi Kagemoto, Yuji Urabe, Tomohiro Miwata, Shiro Oka, Hidenori Ochi, Yasuhiko Kitadai, Shinji Tanaka and Kazuaki Chayama

      Article first published online: 31 MAR 2016 | DOI: 10.1002/cam4.705

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      The main contribution of our paper is the characteristics of esophageal squamous cell carcinoma (ESCC), and the relationship between metachronous esophageal and/or pharyngeal squamous cell carcinoma (SCC) and the ADH1B & ALDH2 risk alleles. We show that rs1229984, rs671, and smoking status are independently associated with the risk of developing metachronous SCCs. In addition, individuals with three risk factors have a 11.95-fold higher risk for metachrous SCCs than those with no or one risk factors, indicating the cumulative effects of these variations.

    2. You have full text access to this OnlineOpen article
      Development and characterization of an in vitro model of colorectal adenocarcinoma with MDR phenotype

      Lorenzo Cinci, Cristina Luceri, Elisabetta Bigagli, Ilaria Carboni, Sara Paccosi, Astrid Parenti, Daniele Guasti and Marcella Coronnello

      Article first published online: 25 MAR 2016 | DOI: 10.1002/cam4.694

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      HCT-8/R were fully characterized by multidisciplinary approaches. These approaches allowed to highlight poorly explored features of MDR phenotype. HCT-8/R are suitable model to test novel therapeutic strategies.

    3. You have full text access to this OnlineOpen article
      Outcome of patients with nonmetastatic muscle-invasive bladder cancer not undergoing cystectomy after treatment with noncisplatin-based chemotherapy and/or radiotherapy: a retrospective analysis

      Aristotle Bamias, Petros Tsantoulis, Thomas Zilli, Athanasios Papatsoris, Francesca Caparrotti, Christos Kyratsas, Kimon Tzannis, Kostas Stravodimos, Michael Chrisofos, Gregory J. Wirth, Andreas Skolarikos, Dionysios Mitropoulos, Constantinos A. Constantinides, Charalambos Deliveliotis, Christophe E. Iselin, Raymond Miralbell, Pierre-Yves Dietrich and Meletios A. Dimopoulos

      Article first published online: 22 MAR 2016 | DOI: 10.1002/cam4.685

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      We herein report the outcome of patients with muscle-invasive bladder cancer who did not undergo cystectomy and did not receive cisplatin-based chemotherapy as they were unfit for both treatment modalities. Treatment included transurethral resection of the tumor, radiotherapy, and carboplatin-based chemotherapy. The outcome of these patients was poor, reflecting the limited therapeutic options and the lack of clinical research focused on this population.

    4. You have full text access to this OnlineOpen article
      Improved survival time trends in Hodgkin's lymphoma

      Matthew Koshy, Andrew Fairchild, Christina H. Son and Usama Mahmood

      Article first published online: 21 MAR 2016 | DOI: 10.1002/cam4.655

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      This population-based analysis of patients with stage I-IV Hodgkin's disease revealed a higher proportion of patients being diagnosed with stage II disease compared to earlier years. Furthermore, there was a profound improvement in survival over time for patients with Hodgkin's lymphoma which was particularly notable for those with early stage disease.

  8. Reviews

    1. You have full text access to this OnlineOpen article
      The impact of early detection and intervention of breast cancer-related lymphedema: a systematic review

      Chirag Shah, Douglas W. Arthur, David Wazer, Atif Khan, Sheila Ridner and Frank Vicini

      Article first published online: 19 MAR 2016 | DOI: 10.1002/cam4.691

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      Increasing data supports the role of early detection and treatment of breast cancer-related lymphedema. New diagnostic modalities have increased sensitivity allowing for the earlier detection of lymphedema.

  9. Original Research

    1. You have full text access to this OnlineOpen article
      Comparison of prognoses according to non-positive and positive spectrin αII expression detected immunohistochemically in epithelial ovarian carcinoma: a retrospective study.

      Osamu Maeda, Tomoko Miyata-Takata, Kiyosumi Shibata, Hiroaki Kajiyama, Mika Mizuno, Koji Tamakoshi, Yoshie Shimoyama, Shigeo Nakamura and Fumitaka Kikkawa

      Article first published online: 19 MAR 2016 | DOI: 10.1002/cam4.683

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      Spectrin αII expression in ovarian carcinoma surgical specimens can be scored according to the scoring criteria used in human epidermal growth factor receptor 2(HER2). Spectrin αII expression is an independent prognostic factor of overall survival and survival after recurrence in ovarian carcinoma. Spectrin αII expression is a useful predictor of anticancer drug resistance in ovarian carcinoma.

    2. You have full text access to this OnlineOpen article
      Dynamic changes of driver genes’ mutations across clinical stages in nine cancer types

      Xia Li

      Article first published online: 19 MAR 2016 | DOI: 10.1002/cam4.704

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      We investigated 138 driver genes’ mutation changes across clinical stages using 3,477 cases in nine cancer types from the Cancer Genome Atlas (TCGA) and constructed their temporal order relationships. We categorized three patterns for the behaviors of driver genes’ mutation changes in the nine cancer types and observed different codon changes dominated in different stages, highlighting the critical role of the hotspot region for driver gene's tumorigenesis.

  10. Short Reports

    1. You have full text access to this OnlineOpen article
      Mammary tumor growth and metastasis are reduced in c-Kit mutant Sash mice

      Licai He, Zhenfeng Zhu, Shang Chen, Yongping Wang and Haihua Gu

      Article first published online: 19 MAR 2016 | DOI: 10.1002/cam4.696

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      The function of mast cells in breast cancer is still unclear based on published studies. To clarify the role of mast cells in breast cancer, we examined the effects of loss of mast cells on tumor development and metastasis using the well-known transgenic mammary tumor and mast cell deficient mouse models. Our results support a positive role of mast cells in breast cancer by promoting tumor growth and metastasis.

  11. Original Research

    1. You have full text access to this OnlineOpen article
      Blood lipids and prostate cancer: a Mendelian randomization analysis

      Caroline J. Bull, Carolina Bonilla, Jeff M. P. Holly, Claire M. Perks, Neil Davies, Philip Haycock, Oriana Hoi Yun Yu, J. Brent Richards, Rosalind Eeles, Doug Easton, Zsofia Kote-Jarai, Ali Amin Al Olama, Sara Benlloch, Kenneth Muir, Graham G. Giles, Robert J. MacInnis, Fredrik Wiklund, Henrik Gronberg, Christopher A. Haiman, Johanna Schleutker, Børge G. Nordestgaard, Ruth C. Travis, David Neal, Nora Pashayan, Kay-Tee Khaw, Janet L. Stanford, William J. Blot, Stephen Thibodeau, Christiane Maier, Adam S. Kibel, Cezary Cybulski, Lisa Cannon-Albright, Hermann Brenner, Jong Park, Radka Kaneva, Jyotsna Batra, Manuel R. Teixeira, Agnieszka Micheal, Hardev Pandha, George Davey Smith, Sarah J. Lewis, Richard M. Martin and The PRACTICAL consortium

      Article first published online: 19 MAR 2016 | DOI: 10.1002/cam4.695

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      Using a Mendelian randomization framework, we have found some evidence to suggest an association between low-density lipoprotein and triglycerides and more clinically severe PCa, but no evidence between high-density lipoprotein and these outcomes. There is an unmet clinical need to distinguish between indolent PCas and those that will progress to impact a man's life. Our findings indicate that blood lipids may be involved in this distinction.

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      A prognostic model for platinum-doublet as second-line chemotherapy in advanced non-small-cell lung cancer patients

      Hongnan Mo, Xuezhi Hao, Yutao Liu, Lin Wang, Xingsheng Hu, Jianping Xu, Sheng Yang, Puyuan Xing, Youwu Shi, Bo Jia, Yan Wang, Junling Li, Hongyu Wang, Ziping Wang, Yan Sun and Yuankai Shi

      Article first published online: 19 MAR 2016 | DOI: 10.1002/cam4.689

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      This study proposed a prognostic nomogram and a score system for platinum sensitivity in advanced non-small-cell lung cancer (NSCLC), with a median survival of 16.0 months for patients received platinum rechallenge as second-line chemotherapy.

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      Multiplex determination of serological signatures in the sera of colorectal cancer patients using hydrogel biochips

      Veronika I. Butvilovskaya, Sofya B. Popletaeva, Vladimir R. Chechetkin, Zhanna I. Zubtsova, Marya V. Tsybulskaya, Larisa O. Samokhina, Leonid I. Vinnitskii, Aligeydar A. Ragimov, Elena I. Pozharitskaya, Galina A. Grigor´eva, Natalya Y. Meshalkina, Svetlana V. Golysheva, Nadezhda V. Shilova, Nicolai V. Bovin, Aleksander S. Zasedatelev and Alla Y. Rubina

      Article first published online: 19 MAR 2016 | DOI: 10.1002/cam4.692

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      Successful treatment of colorectal cancer depends on its early diagnostics. Aberrant glycosylation of tumor proteins and lipids results in unique signatures of antibodies against modified molecules. We developed a microarray of hydrogel elements that detects and quantifies these antibodies in patients’ sera (glycochip). Together with the measurement of major antibodies and a panel of conventional tumor markers, the glycochip enables early minimally invasive diagnostics of colorectal cancer (CRC) with the sensitivity and specificity exceeding existing methods.

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      The value of breast MRI in high-risk patients with newly diagnosed breast cancer to exclude invasive disease in the contralateral prophylactic mastectomy: Is there a role to choose wisely patients for sentinel node biopsy?

      Vivianne Freitas, Pavel Crystal, Supriya R. Kulkarni, Sandeep Ghai, Karina Bukhanov, Jaime Escallon and Anabel M. Scaranelo

      Article first published online: 18 MAR 2016 | DOI: 10.1002/cam4.663

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      The greatest strength of our study certainly is to confirm the highest MRI-negative predictive value for invasive cancers (IC) in this cohort that was of 100%. The clinical impact is relevant when obtained by a noninvasive preoperative method as the sentinel node biopsy (SLNB) is the standard procedure in patient with invasive disease.

    5. You have full text access to this OnlineOpen article
      Recombinant horseradish peroxidase variants for targeted cancer treatment

      Günther Bonifert, Lisa Folkes, Christoph Gmeiner, Gabi Dachs and Oliver Spadiut

      Article first published online: 15 MAR 2016 | DOI: 10.1002/cam4.668

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      Recombinantly produced glyco-engineered horseradish peroxidase (HRP) C1A is an efficient tool for targeted cancer treatment. Our findings might pave the way for a revival of the powerful combination indole-3-acetic acid IAA/HRP in antibody directed enzyme prodrug therapy (ADEPT) and an increased use of the versatile isoenzyme HRP C1A in cancer research in the future.

    6. You have full text access to this OnlineOpen article
      Radiotherapy plus EGFR TKIs in non-small cell lung cancer patients with brain metastases: an update meta-analysis

      Tao Jiang, Weijie Min, Yanan Li, Zhijian Yue, Chunyan Wu and Caicun Zhou

      Article first published online: 14 MAR 2016 | DOI: 10.1002/cam4.673

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      Radiotherapy plus epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKIs) produced superior risk ratio and disease control rate, and markedly prolonged the central nervous system (CNS)-TTP and overall survival of non-small cell lung cancer (NSCLC) patients with brain metastasis (BM). Meanwhile, combined group increased the incidence of overall adverse effects, especially rash and dry skin. In future, more high-quality and large-scale clinical trials are necessary to confirm the efficacy and safety of radiotherapy plus EGFR TKIs and select the most benefit population in NSCLC patients with BM.

    7. You have full text access to this OnlineOpen article
      The local treatment modalities in FIGO stage I-II small-cell carcinoma of the cervix are determined by disease stage and lymph node status

      Juan Zhou, Hong-Yi Yang, San-Gang Wu, Zhen-Yu He, Huan-Xin Lin, Jia-Yuan Sun, Qun Li and Zhan-Wen Guo

      Article first published online: 14 MAR 2016 | DOI: 10.1002/cam4.687

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      Primary surgery is the most effective local treatment for Federation of Gynecology and Obstetrics (FIGO) stage I–II small-cell carcinoma of the cervix, as adjuvant radiotherapy or radical radiotherapy does not improve survival compared to radical surgery, especially in patients with FIGO stage I and lymph node negative disease.

    8. You have full text access to this OnlineOpen article
      Hypoxia-responsive miR-124 and miR-144 reduce hypoxia-induced autophagy and enhance radiosensitivity of prostate cancer cells via suppressing PIM1

      Hao Gu, Mingzhu Liu, Changmao Ding, Xin Wang, Rui Wang, Xinyu Wu and Ruitai Fan

      Article first published online: 14 MAR 2016 | DOI: 10.1002/cam4.664

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      Hypoxia induced miR-124 and miR-144 downregulation may contribute to a prosurvival mechanism of prostate cancer cells to hypoxia and irradiation at least through attenuated suppressing of PIM1. This presents a potential therapeutic target for the treatment of prostate cancer.

    9. You have full text access to this OnlineOpen article
      Role of cancer stem cells in racial disparity in colorectal cancer

      Lulu Farhana, Fadi Antaki, Mohammad R. Anees, Pratima Nangia-Makker, Stephanie Judd, Timothy Hadden, Edi Levi, Farhan Murshed, Yingjie Yu, Eric Van Buren, Kulsoom Ahmed, Gregory Dyson and Adhip P. N. Majumdar

      Article first published online: 14 MAR 2016 | DOI: 10.1002/cam4.690

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      Although the incidence of and mortality from colorectal cancer (CRC) is higher among the African Americans (AAs) than White people, the underlying biochemical mechanism(s) for this racial disparity are poorly understood. The present investigation is aimed at elucidating the regulatory mechanisms for differences in cancer stem/stem-like cells (CSCs) in colonic neoplasia between AAs and White people by evaluating the role of microRNAs, specifically the microRNA-1207-5p, which is shown to be upregulated in CRC. microRNA (miR)-1207-5p plays a critical role in regulating stemness in colon CSCs and suggests a potential molecular mechanism for the increased risk of CRC among AAs.

    10. You have full text access to this OnlineOpen article
      90-yttrium-ibritumomab tiuxetan consolidation of fludarabine, mitoxantrone, rituximab in intermediate/high-risk follicular lymphoma: updated long-term results after a median follow-up of 7 years

      Beatrice Casadei, Cinzia Pellegrini, Alessandro Pulsoni, Giorgia Annechini, Amalia De Renzo, Vittorio Stefoni, Alessandro Broccoli, Letizia Gandolfi, Federica Quirini, Lorenzo Tonialini, Alice Morigi, Lisa Argnani and Pier Luigi Zinzani

      Article first published online: 14 MAR 2016 | DOI: 10.1002/cam4.684

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      Consolidation with radioimmunotherapy (RIT) after the induction phase including conventional chemoimmunotherapy became an attractive strategy for patients with advanced follicular lymphoma but updates of the long-term outcomes of this approach are lacking. For this reason, we report updated long-term efficacy and toxicity results of a sequential treatment with four cycles of fludarabine, mitoxantrone, and rituximab followed by 90Y-IT as a front-line therapy for untreated patients with intermediate/high-risk follicular lymphoma. These data represented the first evidence of a real role even in the long period of RIT after a fludarabine-containing regimen plus rituximab in the treatment of high-risk follicular lymphoma: a long-term of disease-free survival (63%) and a relevant patients' responsiveness to subsequent therapies.

    11. You have full text access to this OnlineOpen article
      Combined detection of serum Dickkopf-1 and its autoantibodies to diagnose esophageal squamous cell carcinoma

      Yu-Hui Peng, Yi-Wei Xu, Hong Guo, Li-Sheng Huang, Hua-Zhen Tan, Chao-Qun Hong, Shan-Shan Li, Li-Yan Xu and En-Min Li

      Article first published online: 14 MAR 2016 | DOI: 10.1002/cam4.702

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      Detection of serum/plasma biomarker may benefit early diagnosis of esophageal squamous cell carcinoma (ESCC). We evaluate the diagnostic value of serum Dickkopf-1 (DKK-1) combined with DKK-1 autoantibodies in a training cohort and a validation cohort. Our findings offers evidence that combined detection of serum DKK1 and DKK1 autoantibodies has the power of discrimination between early ESCC patients and normal controls. Moreover, serum DKK-1 and DKK-1 autoantibody may be potential markers of therapeutic surveillance for ESCC.

  12. Short Reports

    1. You have full text access to this OnlineOpen article
      History of chickenpox in glioma risk: a report from the glioma international case–control study (GICC)

      E. Susan Amirian, Michael E. Scheurer, Renke Zhou, Margaret R. Wrensch, Georgina N. Armstrong, Daniel Lachance, Sara H. Olson, Ching C. Lau, Elizabeth B. Claus, Jill S. Barnholtz-Sloan, Dora Il'yasova, Joellen Schildkraut, Francis Ali-Osman, Siegal Sadetzki, Robert B. Jenkins, Jonine L. Bernstein, Ryan T. Merrell, Faith G. Davis, Rose Lai, Sanjay Shete, Christopher I. Amos, Beatrice S. Melin and Melissa L. Bondy

      Article first published online: 13 MAR 2016 | DOI: 10.1002/cam4.682

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      Using one of the largest study populations available to date, our study confirms the previously reported inverse association between a positive history of chickenpox and glioma risk. Our results provide additional evidence that the observed protective effect of chickenpox against glioma is unlikely to be coincidental.

  13. Original Research

    1. You have full text access to this OnlineOpen article
      High expression of TRF2, SOX10, and CD10 in circulating tumor microemboli detected in metastatic melanoma patients. A potential impact for the assessment of disease aggressiveness

      Elodie Long, Marius Ilie, Coraline Bence, Catherine Butori, Eric Selva, Salomé Lalvée, Christelle Bonnetaud, Gilles Poissonnet, Jean-Philippe Lacour, Philippe Bahadoran, Patrick Brest, Eric Gilson, Robert Ballotti, Véronique Hofman and Paul Hofman

      Article first published online: 6 MAR 2016 | DOI: 10.1002/cam4.661

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      We show that circulating tumor cells are frequently detected in blood of MMPs either isolated or as circulating tumor microemboli. The detection of circulating tumor microemboli (CTMs) is synonymous of a higher metastatic potential at baseline and after first line of treatment with Vemurafenib. Higher expression of TRF2, CD10, and SOX10 in CTMs correlated with worse prognosis in MMPs, whereas these molecules were only weakly or not expressed in isolated circulating tumor cells (CTCs).

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      Glasgow prognostic score is an independent marker for poor prognosis with all cases of epithelial ovarian cancer

      Chiaki Omichi, Keiichiro Nakamura, Junko Haraga, Hisashi Masuyama and Yuji Hiramatsu

      Article first published online: 1 MAR 2016 | DOI: 10.1002/cam4.681

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      This study investigated whether inflammatory markers of the Glasgow prognostic score (GPS) predicted progression-free survival (PFS) and overall survival (OS) for patients with all cases of epithelial ovarian cancer (OC). GPS can serve as an indicator of poor prognosis in patients with all stages of OC cancer, including early-stage disease and regardless of histology.

    3. You have full text access to this OnlineOpen article
      Outcomes of unplanned sarcoma excision: impact of residual disease

      Chris Charoenlap, Jungo Imanishi, Takaaki Tanaka, John Slavin, Samuel Y. Ngan, Sarat Chander, Michelle Maree Dowsey, Chatar Goyal and Peter F.M. Choong

      Article first published online: 1 MAR 2016 | DOI: 10.1002/cam4.615

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      Residual disease in unplanned excision of soft tissue sarcoma was a poor prognostic predictor for all oncological outcomes. Soft tissue sarcomas should be treated in specialized centers and unplanned excision should be avoided because of its detrimental effect especially when residual disease remains after unplanned excision.

    4. You have full text access to this OnlineOpen article
      Long-term risk of gastrointestinal cancers in persons with gastric or duodenal ulcers

      Kirstine K. Søgaard, Dóra K Farkas, Lars Pedersen, Jennifer L. Lund, Reimar W. Thomsen and Henrik T. Sørensen

      Article first published online: 29 FEB 2016 | DOI: 10.1002/cam4.680

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      Patients with gastric ulcer and duodenal ulcer have an increased risk of all gastrointestinal cancers, compared with the general population. Site-specific absolute cancer risks were similarly low in both Peptic ulcer disease (PUD) cohorts, and the direction of the associations with both gastric and other GI cancers was consistent among patients with the two ulcer types.

    5. You have full text access to this OnlineOpen article
      EphA4-deleted microenvironment regulates cancer development and leukemoid reaction of the isografted 4T1 murine breast cancer via reduction of an IGF1 signal

      Xuefeng Jing, Takashi Sonoki, Masayasu Miyajima, Takahiro Sawada, Nanako Terada, Shigeki Takemura and Kazushige Sakaguchi

      Article first published online: 29 FEB 2016 | DOI: 10.1002/cam4.670

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      Host EphA4 expression regulates cancer development mainly via EphA4-mediated IGF1 synthesis signal. Thus, targeting this signaling pathway may provide a potential therapeutic option for cancer treatment.

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      Laparoscopic surgery for patients with colorectal cancer produces better short-term outcomes with similar survival outcomes in elderly patients compared to open surgery

      Soo Yun Moon, Sohee Kim, Soo Young Lee, Eon Chul Han, Sung-Bum Kang, Seung-Yong Jeong, Kyu Joo Park, Jae Hwan Oh and On behalf of the SEoul COlorectal Group (SECOG)

      Article first published online: 29 FEB 2016 | DOI: 10.1002/cam4.671

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      In this study, laparoscopic colorectal surgery in elderly patients achieved better results than open surgery in terms of bowel function recovery, length of hospital stay, and postoperative complications. Overall survival and recurrence-free survival following laparoscopic and open colorectal resections were similar in the elderly population. These findings indicate that laparoscopic colorectal surgery in elderly patients is safe and feasible, and should be considered as a treatment option.

    7. You have full text access to this OnlineOpen article
      Body mass index and survival after diagnosis of invasive breast cancer: a study based on the Japanese National Clinical Database—Breast Cancer Registry

      Masaaki Kawai, Ai Tomotaki, Hiroaki Miyata, Takayuki Iwamoto, Naoki Niikura, Keisei Anan, Naoki Hayashi, Kenjiro Aogi, Takanori Ishida, Hideji Masuoka, Kotaro Iijima, Shinobu Masuda, Koichiro Tsugawa, Takayuki Kinoshita, Seigo Nakamura and Yutaka Tokuda

      Article first published online: 29 FEB 2016 | DOI: 10.1002/cam4.678

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      Few studies have reported the association between body mass index and outcome among Asian breast cancer patients. We analyzed data for 20,090 female invasive breast cancer patients who had been followed up for a median period of 6.7 years (119,873.4 person years) entered in the National Clinical Database–Breast Cancer Registry between 2004 and 2006. The timing of body mass index (BMI) measurement was not specified. Being obese or underweight is associated with a higher risk of death among female breast cancer patients in Japan.

    8. You have full text access to this OnlineOpen article
      MiR-24 enhances radiosensitivity in nasopharyngeal carcinoma by targeting SP1

      Min Kang, Jingjian Xiao, Jun Wang, Pingting Zhou, Tingting Wei, Tingting Zhao and Rensheng Wang

      Article first published online: 29 FEB 2016 | DOI: 10.1002/cam4.660

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      This study aimed to investigate the effect of microRNA (miR)-24 on the radiosensitivity of NPC cells. The results of this study suggested that the identified miR-24/Sp1 pathway contributed to the elucidation of the mechanisms of radiosensitivity in human NPC and that it may represent a potential therapeutic target.

    9. You have full text access to this OnlineOpen article
      The prognostic significance of monoclonal immunoglobulin gene rearrangement in conjunction with histologic B-cell aggregates in the bone marrow of patients with diffuse large B-cell lymphoma

      Yoon Ah Cho, Woo Ick Yang, Jae-Woo Song, Yoo Hong Min and Sun Och Yoon

      Article first published online: 29 FEB 2016 | DOI: 10.1002/cam4.679

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      Histologic B-cell aggregates were more associated with monoclonality than polyclonality. A combination of monoclonality and histologic B-cell aggregates within the bone marrow was highly associated with poor prognosis and could be used to determine high-risk DLBLC patients with greater sensitivity and specificity than conventional microscopic examination or immunoglobulin gene rearrangement study alone.

    10. You have full text access to this OnlineOpen article
      Association between baseline serum glucose, triglycerides and total cholesterol, and prostate cancer risk categories

      Rhonda Arthur, Henrik Møller, Hans Garmo, Lars Holmberg, Pår Stattin, Håkan Malmstrom, Mats Lambe, Niklas Hammar, Göran Walldius, David Robinson, Ingmar Jungner and Mieke Van Hemelrijck

      Article first published online: 29 FEB 2016 | DOI: 10.1002/cam4.665

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      Our findings suggest that men with glucose in the diabetic range are more likely to have lower PSA levels, but higher grade or advanced PCa. Conversely, men with glucose in the prediabetic range and those with hypertriglyceridemia tended to have higher PSA levels as well as higher grade or more advanced PCa.

    11. You have full text access to this OnlineOpen article
      Recreational physical activity and ovarian cancer risk in African American women

      Sarah E. Abbott, Elisa V. Bandera, Bo Qin, Lauren C. Peres, Patricia G. Moorman, Jill Barnholtz-Sloan, Ann G. Schwartz, Ellen Funkhouser, Edward S. Peters, Michele L. Cote, Anthony J. Alberg, Paul Terry, Melissa Bondy, Lisa E. Paddock, Sydnee Crankshaw, Frances Wang, Fabian Camacho and Joellen M. Schildkraut

      Article first published online: 29 FEB 2016 | DOI: 10.1002/cam4.677

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      This is the first study of recreational physical activity (RPA) and ovarian cancer in an exclusively African American population, who have a higher prevalence of obesity and poorer ovarian cancer survival compared with whites. We found that mild and strenuous intensity RPA may be associated with reduced ovarian cancer risk. Further, our data suggest that these associations may be more pronounced in obese women.

    12. You have full text access to this OnlineOpen article
      Risk of breast cancer after false-positive results in mammographic screening

      Marta Román, Xavier Castells, Solveig Hofvind and My von Euler-Chelpin

      Article first published online: 25 FEB 2016 | DOI: 10.1002/cam4.646

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      In this joint analysis based on individual level data from the population-based screening programs in Copenhagen and Funen in Denmark, Norway, and Spain, we estimated that women with false-positive screening results had a twofold risk of a later screen detected breast cancer compared to women with negative screening results. The increased risk should be considered when exploring the possibilities of stratified screening strategies.

  14. OrIginal Research

    1. You have full text access to this OnlineOpen article
      Effects of Nrf2 silencing on oxidative stress-associated intestinal carcinogenesis in mice

      Yuh Yokoo, Aki Kijima, Yuji Ishii, Shinji Takasu, Takuma Tsuchiya and Takashi Umemura

      Article first published online: 21 FEB 2016 | DOI: 10.1002/cam4.672

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      Nrf2 deficiency increased susceptibility to oxidative stress-induced small intestinal carcinogenesis in mice, in which COX2 overexpression followed by cell-cycle progression was involved. Individuals having single-nucleotide polymorphisms in NRF2 may have a risk of colorectal cancer to some extent.

  15. Original Research

    1. You have full text access to this OnlineOpen article
      Suppression of prostate cancer progression by cancer cell stemness inhibitor napabucasin

      Yiming Zhang, Zhong Jin, Huimin Zhou, Xueting Ou, Yawen Xu, Hulin Li, Chunxiao Liu and Bingkun Li

      Article first published online: 21 FEB 2016 | DOI: 10.1002/cam4.675

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      A novel cancer cell stemness inhibitor, napabucasin, suppressed advanced prostate cancer effectively via inhibition of prostate stemness-high cancer cells.

    2. You have full text access to this OnlineOpen article
      Human polyomaviruses and incidence of cutaneous squamous cell carcinoma in the New Hampshire skin cancer study

      Anala Gossai, Tim Waterboer, Anne G. Hoen, Shohreh F. Farzan, Heather H. Nelson, Angelika Michel, Martina Willhauck-Fleckenstein, Brock C. Christensen, Ann E. Perry, Michael Pawlita and Margaret R. Karagas

      Article first published online: 21 FEB 2016 | DOI: 10.1002/cam4.674

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      It is currently unclear whether human polyomaviruses (PyV) play a role in the etiology of cutaneous squamous cell carcinoma (SCC). Our findings from a population-based case–control study conducted in the United States provide limited evidence that certain PyV types may be related to the occurrence of SCC of the skin in the general population.

    3. You have full text access to this OnlineOpen article
      Discussions about reproductive and sexual health among young adult survivors of cancer

      Ying Wang, Leo Chen, Jenny Y. Ruan and Winson Y. Cheung

      Article first published online: 21 FEB 2016 | DOI: 10.1002/cam4.666

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      We reviewed medical records of young adult cancer survivors regarding reproductive and sexual health discussions with their physicians. Our study highlights that such conversations occur inadequately, even though this dialog is associated with a higher likelihood of fertility preservation strategies.

    4. You have full text access to this OnlineOpen article
      Comparison of outcome of patients with CLL who are referred or nonreferred to a specialized CLL clinic: a Canadian population-based study

      Sara Beiggi, Versha Banerji, Angela Deneka, Jane Griffith, Spencer B. Gibson and James B. Johnston

      Article first published online: 18 FEB 2016 | DOI: 10.1002/cam4.559

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      Chronic lymphocytic leukemia and small lymphocytic lymphoma (CLL/SLL) patients in Manitoba are either referred to the CLL Clinic at CancerCare Manitoba or are followed by other hematologists and general practitioners. Patients seen in the CLL clinic have an improved overall survival (OS) compared to nonreferred patients and this appears to be primarily related to improved OS in the elderly.

    5. You have full text access to this OnlineOpen article
      Role of palliative radiotherapy in the management of mural cardiac metastases: who, when and how to treat? A case series of 10 patients

      Alireza Fotouhi Ghiam, Laura A. Dawson, Wael Abuzeid, Sarah Rauth, Raymond W. Jang, Eric Horlick and Andrea Bezjak

      Article first published online: 16 FEB 2016 | DOI: 10.1002/cam4.619

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      The success of palliative radiotherapy in improving clinical symptoms and achieving good local control for mural cardiac metastases calls for further consideration of this modality either as a single modality or in combination with surgery and/or chemotherapy. Our experience shows that common palliative dose fractionation schemes (such as 8, 20, or 30 Gy in 1, 5, and 10 fractions, respectively) is safe and effective and should be considered early in the management of these patients.

    6. You have full text access to this OnlineOpen article
      Is there a progression-free survival benefit of first-line crizotinib versus standard chemotherapy and second-line crizotinib in ALK-positive advanced lung adenocarcinoma? A retrospective study of Chinese patients

      Shaohua Cui, Yizhuo Zhao, Lili Dong, Aiqin Gu, Liwen Xiong, Jialin Qian, Wei Zhang, Yanjie Niu, Feng Pan and Liyan Jiang

      Article first published online: 16 FEB 2016 | DOI: 10.1002/cam4.659

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      There was a significant progression-free survival (PFS) benefit of first-line crizotinib versus first-line standard chemotherapy in Chinese patients with anaplastic lymphoma kinase (ALK)-positive lung adenocarcinoma. Additionally, crizotinib showed promising efficacy in patients who received it as second-line therapy after progressive disease (PD) had occurred on first-line chemotherapy.

  16. Reviews

    1. You have full text access to this OnlineOpen article
      The role of stem cells in the prevention and treatment of radiation-induced xerostomia in patients with head and neck cancer

      Daan Nevens and Sandra Nuyts

      Article first published online: 16 FEB 2016 | DOI: 10.1002/cam4.609

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      This review discusses the current knowledge of salivary gland stem cells in radiation-induced xerostomia and their value in the prevention and treatment of radiation-induced xerostomia.

  17. Original Research

    1. You have full text access to this OnlineOpen article
      A novel approach to predict cetuximab-induced hypersensitivity reaction: detection of drug-specific IgE on basophils

      Takuya Iwamoto, Akiharu Okamoto, Hajime Ishinaga, Kasumi Shimizu, Alberto A. Gayle, Naoya Arai, Kazuhiko Takeuchi and Masahiro Okuda

      Article first published online: 16 FEB 2016 | DOI: 10.1002/cam4.658

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      We indicated for the first time that a quantification of the interaction between cetuximab and IgE on basophils, the site responsible for IgE-mediated allergy, allows a more precise definition of the clinical presentation of allergic reaction due to cetuximab.

    2. You have full text access to this OnlineOpen article
      Glycosylation status of serum immunoglobulin G in patients with prostate diseases

      Saiko Kazuno, Jun-ichi, Furukawa, Yasuro Shinohara, Kimie Murayama, Makoto Fujime, Takashi Ueno and Tsutomu Fujimura

      Article first published online: 16 FEB 2016 | DOI: 10.1002/cam4.662

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      We report that N-linked (N-acetylhexosamine)2(deoxyhexose)(mannose)3(N-acetylglucosamine)2 was significantly increased in the serum IgG heavy chains of patients with prostate cancer compared with that of either benign prostatic disease patients or healthy normal subjects, whereas (hexose)(N-acetylhexosamine)2(deoxyhexose)(mannose)3 (N-acetylglucosamine)2 was more abundant in the heavy chains of healthy subjects and benign prostatic disease patients. Thus, an absence of the terminal hexose of N-linked glycans has been closely connected to the progression of prostate cancer.

  18. Reviews

    1. You have full text access to this OnlineOpen article
      Acute pancreatitis as a complication of childhood cancer treatment

      Milica Stefanović, Janez Jazbec, Fredrik Lindgren, Milutin Bulajić and Matthias Löhr

      Article first published online: 13 FEB 2016 | DOI: 10.1002/cam4.649

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      Acute pancreatitis (AP) is now well recognized as a possible complication of childhood cancer treatment. This review summarizes the current literature and presents the various etiological factors for AP during chemotherapy as well as modern trends in the diagnosis and therapy of AP in children.

  19. Original Research

    1. You have full text access to this OnlineOpen article
      Predictors of adherence to a 12-week exercise program among men treated for prostate cancer: ENGAGE study

      Melinda Craike, Cadeyrn J. Gaskin, Kerry S. Courneya, Steve F. Fraser, Jo Salmon, Patrick J. Owen, Suzanne Broadbent and Patricia M. Livingston

      Article first published online: 12 FEB 2016 | DOI: 10.1002/cam4.639

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      Adherence to a structured exercise program among men treated for prostate cancer was predicted by severity of hormonal symptoms and ability to perform daily tasks and leisure activities. Cancer-specific quality of life factors need to be considered when conducting exercise programs for men who have been treated for prostate cancer.

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      Machine learning-based classification of diffuse large B-cell lymphoma patients by eight gene expression profiles

      Shuangtao Zhao, Xiaoli Dong, Wenzhi Shen, Zhen Ye and Rong Xiang

      Article first published online: 11 FEB 2016 | DOI: 10.1002/cam4.650

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      To classify diffuse large B-cell lymphoma (DLBCL) samples validly, a classified model based on machine learning was developed by eight significant genes (MYBL1, LMO2, BCL6, MME, IRF4, NFKBIZ, PDE4B, and SLA). As a result, patients in the training and validated cohorts were stratified into two subgroups (GCB and Non-GCB) with 94%, 91%, and 94.4% concordance with gene expression profiling (GEP), respectively. In conclusion, our new model could stratify DLBCL patients with CHOP/R-CHOP regimen matching GEP subtypes effectively.

    3. You have full text access to this OnlineOpen article
      Activation of MEK1/2-ERK1/2 signaling during NNK-induced lung carcinogenesis in female A/J mice

      Keiko Yamakawa, Masanao Yokohira, Yuko Nakano, Sosuke Kishi, Shohei Kanie and Katsumi Imaida

      Article first published online: 10 FEB 2016 | DOI: 10.1002/cam4.652

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      In this study, we immunohistochemically examined expression of phosphorylated forms of ERK1/2 (pERK1/2) and MAP/ERK kinase 1/2 (pMEK1/2) proteins and correlation between ERK activation and mutation of Kras, in a mouse lung carcinogenesis model.The pERK1/2 positive score in adenocarcinomas, was higher than that in hyperplasias and adenomas. Activation of ERK1/2 plays a key role in malignant transformation during lung carcinogenesis featuring Kras mutaion.

    4. You have full text access to this OnlineOpen article
      Kinetics of postdiagnosis platelet count with overall survival of pancreatic cancer: a counting process approach

      Yuanyuan Xiao, Hua Xie, Zhihui Xie, Zhenyi Shao, Wen Chen, Guoyou Qin and Naiqing Zhao

      Article first published online: 10 FEB 2016 | DOI: 10.1002/cam4.644

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      Dynamic survival methods are rarely seen in analyzing time-varying blood indicators and cancer survival. In this study, through the application of counting process approach and the subsequent multiple failure-time Cox model, we found that among 311 retrospectively determined pancreatic cancer (PC) patients diagnosed between 2012 and 2013, postdiagnosis thrombocytopenia was consistently associated with a compromised overall survival.

    5. You have full text access to this OnlineOpen article
      Radiation-induced mesothelioma among long-term solid cancer survivors: a longitudinal analysis of SEER database

      Andrea Farioli, Marta Ottone, Alessio G. Morganti, Gaetano Compagnone, Fabrizio Romani, Silvia Cammelli, Stefano Mattioli and Francesco S. Violante

      Article first published online: 10 FEB 2016 | DOI: 10.1002/cam4.656

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      Patients treated with external beam radiotherapy for solid cancers present an increased incidence of mesothelioma compared to nonirradiated patients. However, the clinical impact of radiation-induced mesothelioma is extremely limited.

    6. You have full text access to this OnlineOpen article
      Associations between advanced cancer patients' survival and family caregiver presence and burden

      J. Nicholas Dionne-Odom, Jay G. Hull, Michelle Y. Martin, Kathleen Doyle Lyons, Anna T. Prescott, Tor Tosteson, Zhongze Li, Imatullah Akyar, Dheeraj Raju and Marie A. Bakitas

      Article first published online: 10 FEB 2016 | DOI: 10.1002/cam4.653

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      Advanced cancer patients with caregivers enrolled in a trial had lower survival than patients without caregiver coparticipants although this mortality risk was mostly attributable to higher survival by unmarried patients without caregivers. Higher caregiver demand burden was also associated with decreased patient survival.

    7. You have full text access to this OnlineOpen article
      The cost of cancer: a retrospective analysis of the financial impact of cancer on young adults

      Michelle S. Landwehr, Samantha E. Watson, Catherine F. Macpherson, Katherine A. Novak and Rebecca H. Johnson

      Article first published online: 7 FEB 2016 | DOI: 10.1002/cam4.657

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      Cancer has a devastating and age-specific impact on the finances of young adult (YAs). Dialog between healthcare and survivorship providers and YAs has the potential to empower this population at-risk for adverse financial and psychosocial outcomes, and steer them toward reputable sources of financial support.

    8. You have full text access to this OnlineOpen article
      A prospective ascertainment of cancer incidence in sub-Saharan Africa: The case of Kaposi sarcoma

      Aggrey Semeere, Megan Wenger, Naftali Busakhala, Nathan Buziba, Mwebesa Bwana, Winnie Muyindike, Erin Amerson, Toby Maurer, Timothy McCalmont, Philip LeBoit, Beverly Musick, Constantin Yiannoutsos, Robert Lukande, Barbara Castelnuovo, Miriam Laker-Oketta, Andrew Kambugu, David Glidden, Kara Wools-Kaloustian and Jeffrey Martin

      Article first published online: 28 JAN 2016 | DOI: 10.1002/cam4.618

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      Estimation of incidence is fundamental to cancer epidemiology but poses considerable challenges in resource-limited settings. In East Africa, we demonstrate how a focused effort to improve cancer diagnosis in combination with an already well-enumerated at-risk denominator made a healthcare system-based population fertile ground for estimating the incidence of Kaposi sarcoma (KS). We show that the overall incidence of KS in HIV-infected adults far exceeds the incidence of the most common cancers in resource-rich settings.

    9. You have full text access to this OnlineOpen article
      PAI-1, a target gene of miR-143, regulates invasion and metastasis by upregulating MMP-13 expression of human osteosarcoma

      Mio Hirahata, Mitsuhiko Osaki, Yusuke Kanda, Yui Sugimoto, Yusuke Yoshioka, Nobuyoshi Kosaka, Fumitaka Takeshita, Tomohiro Fujiwara, Akira Kawai, Hisao Ito, Takahiro Ochiya and Futoshi Okada

      Article first published online: 28 JAN 2016 | DOI: 10.1002/cam4.651

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      Experiments conducted in vitro and in vivo and also clinical samples show that plasminogen activator inhibitor-1 (PAI-1) is related to invasion via up regulation of matrix metalloprotease 13 resulting in metastasis. The findings suggest that PAI-1 is likely to therapeutic target for preventing lung metastasis in human osteosarcoma.

    10. You have full text access to this OnlineOpen article
      The effects of hemoglobin levels and their interactions with cigarette smoking on survival in nasopharyngeal carcinoma patients

      Qi Zeng, Lu-Jun Shen, Sheng Li, Ling Chen, Xiang Guo, Chao-Nan Qian and Pei-Hong Wu

      Article first published online: 28 JAN 2016 | DOI: 10.1002/cam4.647

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      Post-RT Hb level is an important predictor of survival in patients with nasopharyngeal carcinoma (NPC). Smoking index is also an independent predictor of survival in smoking NPC patients. The positive interaction between post-RT Hb level and smoking index contribute to an elevated risk of poor survival.

    11. You have full text access to this OnlineOpen article
      Adjusting for treatment switching in the METRIC study shows further improved overall survival with trametinib compared with chemotherapy

      Nicholas R. Latimer, Helen Bell, Keith R. Abrams, Mayur M. Amonkar and Michelle Casey

      Article first published online: 27 JAN 2016 | DOI: 10.1002/cam4.643

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      Survival analyses for the pivotal METRIC trial in metastatic melanoma were confounded by patients switching treatment from the chemotherapy control arm to the trametinib arm after disease progression. Adjusting for treatment switching lowered the hazard ratio for risk of death compared to results from the standard intent-to-treat analysis; however, adjusted results are sensitive to assumptions associated with adjustment methods.

    12. You have full text access to this OnlineOpen article
      C-type natriuretic peptide in combination with sildenafil attenuates proliferation of rhabdomyosarcoma cells

      Masahiro Zenitani, Takashi Nojiri, Shuichiro Uehara, Koichi Miura, Hiroshi Hosoda, Toru Kimura, Kengo Nakahata, Mikiya Miyazato, Hiroomi Okuyama and Kenji Kangawa

      Article first published online: 26 JAN 2016 | DOI: 10.1002/cam4.642

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      In vitro, C-type natriuretic peptide (CNP), and sildenafil synergistically inhibited proliferation of rhabdomyosarcoma (RMS) cells and decreased extracellular-signal-regulated kinase (ERK) phosphorylation. The synergistic effects on tumor growth inhibition and decrease in phosphorylated ERK levels were confirmed in vivo. CNP in combination with sildenafil exerts antiproliferative effects on RMS cells by attenuating ERK phosphorylation.

    13. You have full text access to this OnlineOpen article
      Pretreatment lymphopenia is an easily detectable predictive and prognostic marker in patients with metastatic esophagus squamous cell carcinoma receiving first-line chemotherapy

      Furong Kou, Zhihao Lu, Jian Li, Xiaotian Zhang, Ming Lu, Jun Zhou, Xicheng Wang, Jifang Gong, Jing Gao, Jie Li, Yan Li and Lin Shen

      Article first published online: 26 JAN 2016 | DOI: 10.1002/cam4.638

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      Pretreatment lymphopenia is a good prognostic factor as well as a predictive factor for tumor response and chemotherapy-related hematological toxicity in metastatic esophagus squamous cell carcinoma.

    14. You have full text access to this OnlineOpen article
      Targeted next-generation sequencing of 22 mismatch repair genes identifies Lynch syndrome families

      Bente A. Talseth-Palmer, Denis C. Bauer, Wenche Sjursen, Tiffany J. Evans, Mary McPhillips, Anthony Proietto, Geoffrey Otton, Allan D. Spigelman and Rodney J. Scott

      Article first published online: 25 JAN 2016 | DOI: 10.1002/cam4.628

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      This study provides evidence that mutations in mismatch repair screening is highly relevant to endometrial cancer diagnostics and that polygenic interactions may be causative in hereditary nonpolyposis colorectal cancer. There is potential for rapid uptake of these testing strategies to the clinic through only small modifications to target regions of molecular tests, or expansion of the patient referral criteria.

    15. You have full text access to this OnlineOpen article
      Family history of breast cancer and its association with disease severity and mortality

      Jennifer C. Melvin, Wahyu Wulaningsih, Zac Hana, Arnie D. Purushotham, Sarah E. Pinder, Ian Fentiman, Cheryl Gillett, Anca Mera, Lars Holmberg and Mieke Van Hemelrijck

      Article first published online: 22 JAN 2016 | DOI: 10.1002/cam4.648

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      Using a London-based hospital cohort of over 5000 breast cancer patients, we aimed to assess the association between family history (by degree) and breast cancer severity, characterized based on tumor characteristics known to exhibit a prognostic effect, as well as the association with breast cancer-specific death. We now show that women with a family history of breast cancer do not require different clinical management than those without a family history.

    16. You have full text access to this OnlineOpen article
      Incidence and outcome of osteonecrosis in children and adolescents after intensive therapy for acute lymphoblastic leukemia (ALL)

      Bhavna Padhye, Luciano Dalla-Pozza, David Little and Craig Munns

      Article first published online: 20 JAN 2016 | DOI: 10.1002/cam4.645

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      Osteonecrosis is a severe complication of treatment for acute lymphoblastic leukemia , especially in patient older than 10 years at diagnosis. Treatment with Zoledronic acid improves pain, but most patients with hip joint involvement have radiological progression despite this treatment.

  20. Short Reports

    1. You have full text access to this OnlineOpen article
      The Barrett-associated variants at GDF7 and TBX5 also increase esophageal adenocarcinoma risk

      Jessica Becker, Andrea May, Christian Gerges, Mario Anders, Claudia Schmidt, Lothar Veits, Tania Noder, Rupert Mayershofer, Nicole Kreuser, Hendrik Manner, Marino Venerito, Jan-Hinnerk Hofer, Orestis Lyros, Constantin J. Ahlbrand, Michael Arras, Sebastian Hofer, Sophie K. M. Heinrichs, Katharina Weise, Timo Hess, Anne C. Böhmer, Nils Kosiol, Ralf Kiesslich, Jakob R. Izbicki, Arnulf H. Hölscher, Elfriede Bollschweiler, Peter Malfertheiner, Hauke Lang, Markus Moehler, Dietmar Lorenz, Katja Ott, Thomas Schmidt, Markus M. Nöthen, Andreas Hackelsberger, Brigitte Schumacher, Oliver Pech, Yogesh Vashist, Michael Vieth, Josef Weismüller, Michael Knapp, Horst Neuhaus, Thomas Rösch, Christian Ell, Ines Gockel and Johannes Schumacher

      Article first published online: 18 JAN 2016 | DOI: 10.1002/cam4.641

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      The authors followed up SNPs at GDF7, TBX5, and ALDH1A2 that showed association with Barrett's esophagus (BE) in a previous study. The sample comprised 542 BE and 1106 esophageal adenocarcinoma (EAC) cases as well as 1602 controls. SNPs at GDF7 and TBX5 are also associated with EAC and thereby risk-conferring also to later stages of the BE/EAC sequence. The variant at ALDH1A2 is associated with BE only, which indicates that this locus plays a more prominent role in early stages of the BE/EAC sequence.

  21. Original Research

    1. You have full text access to this OnlineOpen article
      Triage of patients with AUS/FLUS on thyroid cytopathology: effectiveness of the multimodal diagnostic techniques

      Tae Hyuk Kim, Dae Joon Jeong, Soo Yeon Hahn, Jung Hee Shin, Young Lyun Oh, Chang-Seok Ki, Jong-Won Kim, Ju Young Jang, Yoon Young Cho, Jae Hoon Chung and Sun Wook Kim

      Article first published online: 18 JAN 2016 | DOI: 10.1002/cam4.636

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      The management of an equivocal thyroid cytopathology test remains a complex clinical and public health problem. For patients with atypia (or follicular lesion) of undetermined significance (AUS/FLUS) cytopathology, clinical decision making can be guided by a simple triage scheme based on US findings, repeat biopsy, or BRAFV600E mutation.

    2. You have full text access to this OnlineOpen article
      The effect of comorbidity on the use of adjuvant chemotherapy and type of regimen for curatively resected stage III colon cancer patients

      Mei-Chin Hsieh, Trevor Thompson, Xiao-Cheng Wu, Timothy Styles, Mary B. O'Flarity, Cyllene R. Morris and Vivien W. Chen

      Article first published online: 15 JAN 2016 | DOI: 10.1002/cam4.632

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      The authors show that both the number and severity of comorbidity are significantly associated with receipt of guideline-recommended chemotherapy and type of chemotherapy agent in stage III resected colon cancer patients.

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