Cancer Medicine

Cover image for Vol. 3 Issue 2

Early View (Online Version of Record published before inclusion in an issue)

Edited By: Qingyi Wei, M.D., Ph.D.

Online ISSN: 2045-7634

VIEW

  1. 1 - 42
  1. Original Research

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      Association between adjuvant regional radiotherapy and cognitive function in breast cancer patients treated with conservation therapy

      Osamu Shibayama, Kazuhiro Yoshiuchi, Masatoshi Inagaki, Yutaka Matsuoka, Eisho Yoshikawa, Yuriko Sugawara, Tatsuo Akechi, Noriaki Wada, Shigeru Imoto, Koji Murakami, Asao Ogawa, Akira Akabayashi and Yosuke Uchitomi

      Article first published online: 23 APR 2014 | DOI: 10.1002/cam4.174

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      Breast cancer patients exposed to adjuvant regional radiotherapy in conservation therapy within 1 year after the end of treatment showed a lower Immediate Verbal Memory Index and a Delayed Recall Index of Wechsler Memory Scale-Revised (WMS-R). Radiotherapy exerted an indirect effect on the lower Delayed Recall Index of WMS-R through elevation of plasma interleukin-6 levels.

  2. Letters to the Editor

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      Regarding human cytomegalovirus in neuroblastoma

      Ola Forslund, Linda Holmquist Mengelbier and David Gisselsson

      Article first published online: 16 APR 2014 | DOI: 10.1002/cam4.243

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      Wolmer-Solberg et al., reported that six human neuroblastoma cell lines and the vast majority of clinical neuroblastoma samples contained HCMV DNA and expressed HCMV proteins. We could not replicate the data and therefore remain skeptical towards the prevalence of HCMV DNA in neuroblastomas.

  3. Original Research

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      Outcomes after 90Yttrium-ibritumomab tiuxetan-BEAM in diffuse large B-cell lymphoma: a meta-analysis

      Sophie Auger-Quittet, Yohan Duny, Jean-Pierre Daures and Philipe Quittet

      Article first published online: 16 APR 2014 | DOI: 10.1002/cam4.247

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      Diffuse large B-cell lymphoma (DLBCL) in relapse or refractory kept a poor prognosis despite autologous transplantation. In order to evaluate the clinical effects of Zevalin® in combination with BEAM followed by autologous transplantation in DLBCL, we conducted, to our knowledge, the first literature review and meta-analysis. Twelve studies (409 patients) were included. The 2-year OS and PFS were 85.5% and 67.7%, respectively. These results further emphasize the increase efficacy observed with the Z-BEAM regimen by Shimoni in 2012.

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      Environmental scan of anal cancer screening practices: worldwide survey results

      Jigisha Patel, Irving E. Salit, Michael J. Berry, Alexandra de Pokomandy, Mayura Nathan, Fred Fishman, Joel Palefsky and Jill Tinmouth

      Article first published online: 16 APR 2014 | DOI: 10.1002/cam4.250

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      Rates of anal cancer are increasing, particularly in high-risk populations; however, there is no universal consensus on optimal strategies for anal cancer screening, treatment, and follow-up. This survey is the first step toward understanding anal cancer screening practices around the world.

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      Angiomodulin, a marker of cancer vasculature, is upregulated by vascular endothelial growth factor and increases vascular permeability as a ligand of integrin αvβ3

      Eriko Komiya, Hiroki Sato, Naoko Watanabe, Marii Ise, Shouichi Higashi, Yohei Miyagi and Kaoru Miyazaki

      Article first published online: 16 APR 2014 | DOI: 10.1002/cam4.216

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      This study first demonstrates that angiomodulin (AGM/IGFBP-rP1) is upregulated by VEGF in vascular endothelial cells and functions as a novel cell adhesion ligand of integrin αvβ3, retracting endothelial cells and enhancing vascular permeability. These findings suggest that AGM cooperates with VEGF to induce the aberrant functions of cancer vasculature by interacting with integrin αvβ3.

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      Investigation of cyanine dyes for in vivo optical imaging of altered mitochondrial membrane potential in tumors

      Satoru Onoe, Takashi Temma, Yoichi Shimizu, Masahiro Ono and Hideo Saji

      Article first published online: 16 APR 2014 | DOI: 10.1002/cam4.252

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      Through compound screening, we developed a novel cyanine dye (IC7-1-Bu) which enabled in vivo imaging of tumor mitochondrial hyperpolarization. We found that the length of the dye alkyl side chains greatly affected biodistribution as well as membrane potential sensitivity. This is the first report of a NIR dye that successfully images tumor mitochondrial hyperpolarization in vivo.

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      Intestinal tumor suppression in ApcMin/+ mice by prostaglandin D2 receptor PTGDR

      Brigette L. Tippin, Alan M. Kwong, Michael J. Inadomi, Oliver J. Lee, Jae Man Park, Alicia M. Materi, Virgilio S. Buslon, Amy M. Lin, Lili C. Kudo, Stanislav L. Karsten, Samuel W. French, Shuh Narumiya, Yoshihiro Urade, Eduardo Salido and Henry J. Lin

      Article first published online: 11 APR 2014 | DOI: 10.1002/cam4.251

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      Earlier we discovered that high prostaglandin D2 (PGD2) production inhibits bowel tumors, and here we identify receptor PTGDR as a mediator. PTGDR knockouts raised tumor counts in ApcMin/+ mice 30–40%. More tumors with PTGDR knockouts support a role for PGD2/PTGDR pathways in tumor inhibition—which may have an impact for chemoprevention approaches.

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      Does a parental history of cancer moderate the associations between impaired health status in parents and psychosocial problems in teenagers: a HUNT study

      Elisabeth Jeppesen, Ingvar Bjelland, Sophie D. Fosså, Jon H. Loge, Øystein Sørebø and Alv A. Dahl

      Article first published online: 10 APR 2014 | DOI: 10.1002/cam4.245

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      This study confirmed strong associations between impaired parental health and psychosocial problems in their teenagers. Our hypothesis that a history of parental cancer had small effects on these associations was supported. Such a history weakened several of the significant associations between parental impaired health variables and psychosocial problems in their teenagers.

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      AFAP1L1, a novel associating partner with vinculin, modulates cellular morphology and motility, and promotes the progression of colorectal cancers

      Ryo Takahashi, Satoshi Nagayama, Moritoshi Furu, Yoichiro Kajita, YongHui Jin, Tomohisa Kato, Seiya Imoto, Yoshiharu Sakai and Junya Toguchida

      Article first published online: 10 APR 2014 | DOI: 10.1002/cam4.237

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      AFAP1L1 (actin filament-associated protein 1-like 1) modulates cell shape and motility and inhibits anoikis of colorectal cancer cells by associating with vinculin, and will be a predictive biomarker for rectal cancer recurrences.

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      Pretreatment vitamin D level and response to neoadjuvant chemotherapy in women with breast cancer on the I-SPY trial (CALGB 150007/150015/ACRIN6657)

      Amy S. Clark, Jinbo Chen, Shiv Kapoor, Claire Friedman, Carolyn Mies, Laura Esserman, Angela DeMichele and for the I-SPY1 Investigators

      Article first published online: 9 APR 2014 | DOI: 10.1002/cam4.235

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      This study examined the association between vitamin D level and response to neoadjuvant chemotherapy (NACT). Vitamin D level was not associated with response to NACT despite adequate power. In exploratory analysis, vitamin D level was associated with proliferation as measured by Ki67.

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      Prognostic significance of specific anti-WT1 IgG antibody level in plasma in patients with ovarian carcinoma

      Charlotta Andersson, Yusuke Oji, Nina Ohlson, Sihan Wang, Xingru Li, Ulrika Ottander, Eva Lundin, Haruo Sugiyama and Aihong Li

      Article first published online: 8 APR 2014 | DOI: 10.1002/cam4.244

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      We found that WT1 IgG antibody levels in plasma and high-WT1 expression in tissue specimens were associated with poor outcome in the subgroup of ovarian carcinoma (OC) patients. The results indicate that WT1 antibody measurements and WT1 protein staining could be useful as biomarkers for patient outcome in the subtypes of OC for individualized therapy postoperation and support the hypothesis that subtypes of OCs differ considerably in characteristics.

  4. Commentary

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      The scientific method: pillar and pitfall of cancer research

      Shi-Ming Tu, Mehmet Asim Bilen and Nizar M. Tannir

      Article first published online: 8 APR 2014 | DOI: 10.1002/cam4.248

  5. Reviews

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      Complement anaphylatoxins as immune regulators in cancer

      Eli T. Sayegh, Orin Bloch and Andrew T. Parsa

      Article first published online: 8 APR 2014 | DOI: 10.1002/cam4.241

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      Despite the longstanding concept of complement as a beneficial host immune defense, recent research has implicated the complement anaphylatoxins as propagators of tumor growth and progression. A systematic review of the literature identified six studies in experimental cancer models, which collectively suggest that complement regulates the composition and functional phenotype of tumor-infiltrating immune cells.

  6. Original Research

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      Fibroblast growth factor signaling and inhibition in non-small cell lung cancer and their role in squamous cell tumors

      Ravi Salgia

      Article first published online: 7 APR 2014 | DOI: 10.1002/cam4.238

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      FGF receptor is important in a number of malignancies. It will be important to target this receptor and related molecules as a novel therapy.

  7. Reviews

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      A role for G-CSF and GM-CSF in nonmyeloid cancers

      Alexander M. Aliper, Victoria P. Frieden-Korovkina, Anton Buzdin, Sergey A. Roumiantsev and Alex Zhavoronkov

      Article first published online: 1 APR 2014 | DOI: 10.1002/cam4.239

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      The Granulocyte colony-stimulating factor (G-CSF) or granulocyte-macrophage colony-stimulating factor (GM-CSF)-secreting cancers albeit not very common are, however, among the most rapidly advancing ones due to a cytokine-mediated immune suppression and tumor angiogenesis. Rapid diagnostic tools to differentiate G-CSF- or GM-CSF-secreting cancers are not well developed thus complicating individualized treatment choices for these patients. We analyzed the role of G-CSF and GM-CSF in the cytokine-secreting tumors of brain, lung, bladder, colon, skin, and prostate and provided insights into molecular components of the cytokine/receptor signaling. Given the increasing use of G-/GM-CSF-based vaccines and the recombinant cytokines in adjuvant treatments, there is a possibility of adverse effects and accelerating of the tumor growth in cancers addicted to the G-/GM-CSF-activated signaling.

  8. Original Research

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      A retrospective analysis of the effect of intraoperative opioid dose on cancer recurrence after non-small cell lung cancer resection

      Juan P. Cata, Visesh Keerty, Dinesh Keerty, Lei Feng, Peter H. Norman, Vijaya Gottumukkala, John R. Mehran and Mitchel Engle

      Article first published online: 1 APR 2014 | DOI: 10.1002/cam4.236

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      The use of opioid has been linked to immune suppression and animal studies suggest their association with tumor growth. In the present study, we demonstrated a possible association between cancer recurrence and intraoperative opioid use in stage I non-small cell lung cancer but not in stages II and III.

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      HER2 and GATA4 are new prognostic factors for early-stage ovarian granulosa cell tumor—a long-term follow-up study

      Anniina Färkkilä, Noora Andersson, Ralf Bützow, Arto Leminen, Markku Heikinheimo, Mikko Anttonen and Leila Unkila-Kallio

      Article first published online: 29 MAR 2014 | DOI: 10.1002/cam4.230

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      The majority of ovarian granulosa cell tumors (GCTs) are diagnosed at early stage, but 24% recur and prognostic factors are lacking. We here find that HER2 and GATA4 are new molecular prognostic factors that can be utilized in the prognostic evaluation of patients with also early-stage GCT.

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      Modulation by metformin of molecular and histopathological alterations in the lung of cigarette smoke-exposed mice

      Alberto Izzotti, Roumen Balansky, Francesco D'Agostini, Mariagrazia Longobardi, Cristina Cartiglia, Rosanna T. Micale, Sebastiano La Maestra, Anna Camoirano, Gancho Ganchev, Marietta Iltcheva, Vernon E. Steele and Silvio De Flora

      Article first published online: 28 MAR 2014 | DOI: 10.1002/cam4.234

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      The role of metformin in pulmonary carcinogenesis is unclear. In mice exposed to cigarette smoke, starting at birth, metformin induced a systemic clastogenic damage, formation of DNA adducts, oxidative DNA damage, and extensive downregulation of microRNAs in lung. Metformin did not prevent smoke-induced lung tumors but inhibited preneoplastic lesions in both lung and kidney.

  9. Short Reports

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      Interleukin-7 receptor-α gene mutations are not detected in adult T-cell acute lymphoblastic leukemia

      Uri Rozovski, Ping Li, David Harris, Maro Ohanian, Hagop Kantarjian and Zeev Estrov

      Article first published online: 26 MAR 2014 | DOI: 10.1002/cam4.194

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      We report that a “driver” mutation in the IL7R, recently described in 10% of childhood T-ALL was not detected in 35 adult patients with T-ALL. Accumulating data on age-related differences in the genetic makeup of ALL may explain why prognosis and response to therapy differ between adult and children with ALL.

  10. Original Research

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      Comparison of HER2 expression between primary colorectal cancer and their corresponding metastases

      Won-Suk Lee, Yeon Ho Park, Jung Nam Lee, Jeong-Heum Baek, Tae-Hoon Lee and Seung Yeon Ha

      Article first published online: 25 MAR 2014 | DOI: 10.1002/cam4.228

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      HER2 was overexpressed in colon tumors harboring KRAS mutations in 5.3% of cases. HER2-directed target therapy may be beneficial in this subgroup of patients.

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      Enzyme 15-lipoxygenase 1 promotes hypoxia-inducible factor 1α turnover and reduces vascular endothelial growth factor expression: implications for angiogenesis

      Hua Zhong, Ruoxiang Wang, Uddhav Kelavkar, Christopher Y. Wang and Jonathan Simons

      Article first published online: 25 MAR 2014 | DOI: 10.1002/cam4.227

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      In a study to elucidate the fatty acid metabolism effect on regulating the HIF-1α/HIF-1 pathway in tumor cells, we have demonstrated that 15-lipoxygenase 1 (15-LO1) promotes HIF-1α ubiquitination and turnover, and thus suppresses vascular endothelial growth factor (VEGF) expression. The results of this study, together with our prior findings, support a balance between the cyclooxygenase-2/prostaglandin E2 (COX-2/PGE2) pathway and linoleic acid/15-LO1 pathway in the regulation of HIF-1α expression and HIF-1 transcriptional activity.

  11. Reviews

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      Modern treatment in chronic lymphocytic leukemia: impact on survival and efficacy in high-risk subgroups

      Antonio Cuneo, Francesco Cavazzini, Maria Ciccone, Giulia Daghia, Olga Sofritti, Elena Saccenti, Massimo Negrini and Gian Matteo Rigolin

      Article first published online: 19 MAR 2014 | DOI: 10.1002/cam4.226

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      Modern treatment approaches in CLL were reviewed, with special reference to (1) their impact on OS in different age groups and (2) their activity in specific molecular cytogenetic subsets and high-risk disease.

  12. Original Research

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      Tumor cell-expressed SerpinB2 is present on microparticles and inhibits metastasis

      Wayne A. Schroder, Lee D. Major, Thuy T. Le, Joy Gardner, Matthew J. Sweet, Sabina Janciauskiene and Andreas Suhrbier

      Article first published online: 19 MAR 2014 | DOI: 10.1002/cam4.229

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      SerpinB2 expression by certain tumors, particularly breast cancer, is associated with a favorable prognosis. We provide evidence that SerpinB2 associates with phosphatidylserine on the surface of cancer cell-derived microparticles, and that this SerpinB2 is able to inhibit urokinase and thereby cancer cell migration/invasion. This provides for the first time a mechanistic understanding of SerpinB2's activity in tumor biology..

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      Clinical effectiveness of posaconazole versus fluconazole as antifungal prophylaxis in hematology–oncology patients: a retrospective cohort study

      Hsiang-Chi Kung, Melissa D. Johnson, Richard H. Drew, Paramita Saha-Chaudhuri and John R. Perfect

      Article first published online: 19 MAR 2014 | DOI: 10.1002/cam4.225

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      In adults receiving first induction or first reinduction chemotherapy for acute myelogenous leukemia (AML) or myelodysplastic syndrome (MDS), posaconazole prophylaxis was associated with significantly fewer invasive fungal infections than fluconazole prophylaxis. This study demonstrates superior effectiveness of posaconazole over fluconazole as prophylaxis of invasive fungal disease in AML and MDS patients.

  13. Reviews

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      The Ca2+-activated Cl channel, ANO1 (TMEM16A), is a double-edged sword in cell proliferation and tumorigenesis

      Zhiqiang Qu, Weicheng Yao, Ruyong Yao, Xiangping Liu, Kuai Yu and Criss Hartzell

      Article first published online: 18 MAR 2014 | DOI: 10.1002/cam4.232

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      The Ca2+-activated Cl channel, ANO1 overexpression occurs in the cancer tissues frequently with 11q13 chromosome amplification. Poor prognosis of many types of cancers has been closely correlated with ANO1 gene amplification and protein overexpression. Recent research suggests that it is ANO1 channel function that is involved in the tumorigenesis. This review summarizes how functional ANO1 possibly causes malignant transformation of tissues via signaling pathways, for example, MAPK.

  14. Original Research

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      Most lobular carcinoma in situ and atypical lobular hyperplasia diagnosed on core needle biopsy can be managed clinically with radiologic follow-up in a multidisciplinary setting

      Lavinia P. Middleton, Nour Sneige, Robin Coyne, Yu Shen, Wenli Dong, Peter Dempsey and Therese B. Bevers

      Article first published online: 18 MAR 2014 | DOI: 10.1002/cam4.223

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      A retrospective study of patients with atypical lobular hyperplasia (ALH) and lobular carcinoma in situ (LCIS), who were presented to multidisciplinary conference and offered chemoprevention and monitored, revealed that clinical management is an efficacious alternative to surgical excision for well-defined in situ lobular lesions with a low potential for an upgrade at excision.

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      Decreased decorin expression in the tumor microenvironment

      Benedek Bozoky, Andrii Savchenko, Hayrettin Guven, Fredrik Ponten, George Klein and Laszlo Szekely

      Article first published online: 17 MAR 2014 | DOI: 10.1002/cam4.231

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      Decorin is a known tumor suppressor in experimental systems. By examining the Human Protein Atlas online database, we compared decorin expression in the stroma of several normal and cancerous tissues. We found that decorin expression was decreased in all the tumors studied.

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      15-LOX-1 suppression of hypoxia-induced metastatic phenotype and HIF-1α expression in human colon cancer cells

      Yuanqing Wu, Fei Mao, Xiangsheng Zuo, Micheline J. Moussalli, Elias Elias, Weiguo Xu and Imad Shureiqi

      Article first published online: 15 MAR 2014 | DOI: 10.1002/cam4.222

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      15-lipoxygenase-1 (15-LOX-1) reexpression in colon cancer cells inhibited survival, vascular endothelial growth factor expression, angiogenesis, cancer cell migration and invasion, and hypoxia-inducible factor-1α protein expression and stability under hypoxia. These findings demonstrate that 15-LOX-1 expression loss in cancer cells promotes metastasis and that therapeutically targeting ubiquitous 15-LOX-1 loss in cancer cells has the potential to be used to suppress metastasis.

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      Modeling tandem AAG8-MEK inhibition in melanoma cells

      Bing Sun, Masahiro Kawahara and Teruyuki Nagamune

      Article first published online: 14 MAR 2014 | DOI: 10.1002/cam4.233

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      We uniquely discovered AAG8 antagonists as new MEK inhibitors in melanoma cells, and model a drug combination strategy for melanoma therapy through investigating the mechanisms of anti-cancer effects and the drug resistance generation of AAG8 antagonism. AAG8 antagonists inhibit the RAS-CRAF-MEK signaling to restrict melanoma cell growth. The finding that MEK plays a central role in resistant mechanism led to our proposal of tandem AAG8-MEK inhibition, which was proved to efficiently kill resistant melanoma cells. This drug combination has instrumental implications for clinical melanoma prevention.

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      Epidemiology and survival of HPV-related tonsillar carcinoma

      Georgios Psychogios, Christoph Alexiou, Abba Agaimy, Kathrin Brunner, Michael Koch, Konstantinos Mantsopoulos, Andrea Tomppert and Heinrich Iro

      Article first published online: 10 MAR 2014 | DOI: 10.1002/cam4.212

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      This study showed an increase in the percentage of p16-positive patients in tonsillar carcinoma from 23.2% between 2005 and 2007 to 58.6% between 2010 and 2012. The majority (80.2%) of p16-positive patients presented with early T-category tumor but most of these (79.0%) also had lymph node metastases. Nevertheless, p16-positive patients had excellent oncologic results and could be considered for de-escalation of treatment.

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      Odds of death after glioblastoma diagnosis in the United States by chemotherapeutic era

      Mitchell S. Wachtel and Shengping Yang

      Article first published online: 10 MAR 2014 | DOI: 10.1002/cam4.213

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      This study provided evidence that temozolomide positively impacted survival and that adding bevacizumab to the regimen further improved survival among US glioblastoma patients in general. Because near-complete follow-up characterizes modern databases, binary logit regression, used here to analyze the data, is an attractive alternative to Cox regression when proportional hazards violations are deemed important.

  15. Short Reports

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      Significant SNPs have limited prediction ability for thyroid cancer

      Shicheng Guo, Yu-Long Wang, Yi Li, Li Jin, Momiao Xiong, Qing-Hai Ji and Jiucun Wang

      Article first published online: 3 MAR 2014 | DOI: 10.1002/cam4.211

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      Five significantly thyroid cancer-associated genetic variants which have been discovered and validated by GWAS and case–control studies were taken as the predictor in nine prediction models. We found that the four SNPs were significantly associated with thyroid cancer in Han Chinese population, but with limited power to predict thyroid cancer.

  16. Original Research

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      Long noncoding RNA HOTAIR is relevant to cellular proliferation, invasiveness, and clinical relapse in small-cell lung cancer

      Hiroshi Ono, Noriko Motoi, Hiroko Nagano, Eisaku Miyauchi, Masaru Ushijima, Masaaki Matsuura, Sakae Okumura, Makoto Nishio, Tetsuro Hirose, Naohiko Inase and Yuichi Ishikawa

      Article first published online: 3 MAR 2014 | DOI: 10.1002/cam4.220

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      We first demonstrated that Hox transcript antisense intergenic RNA (HOTAIR) was expressed in pure small-cell lung cancer (SCLC) and higher expression was significantly related to lymphatic invasion and relapse. Multivariate analyses demonstrated that HOTAIR expression correlated with relapse-free survival. In vitro experiments demonstrated that half of SCLC cell lines expressed HOTAIR at higher levels than normal cells and that, using SBC-3 cells, knockdown of HOTAIR decreased proliferative activity and cellular invasiveness with altered expression of cell adhesion-related genes.

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      Changes in highly sensitive alpha-fetoprotein for the prediction of the outcome in patients with hepatocellular carcinoma after hepatectomy

      Hidenori Toyoda, Takashi Kumada, Toshifumi Tada, Takanori Ito, Atsuyuki Maeda, Yuji Kaneoka, Chiaki Kagebayashi and Shinji Satomura

      Article first published online: 3 MAR 2014 | DOI: 10.1002/cam4.218

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      AFP-L3, tumor biomarker that is specific for hepatocellular carcinoma (HCC) usually decreases after curative hepatectomy as well as AFP and des-gamma-carboxy prothrombin. However, it did not decrease even after curative hepatectomy when AFP-L3 was measured with highly sensitive method, and this will discriminate the outcome of patients with HCC after hepatectomy.

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      Outcome of TCF3-PBX1 positive pediatric acute lymphoblastic leukemia patients in Japan: a collaborative study of Japan Association of Childhood Leukemia Study (JACLS) and Children's Cancer and Leukemia Study Group (CCLSG)

      Daisuke Asai, Toshihiko Imamura, Yuka Yamashita, So-ichi Suenobu, Akiko Moriya-Saito, Daiichiro Hasegawa, Takao Deguchi, Yoshiko Hashii, Mikiya Endo, Naoki Hatakeyama, Hirohide Kawasaki, Hiroki Hori, Keizo Horibe, Keiko Yumura-Yagi, Junichi Hara, Arata Watanabe, Atsushi Kikuta, Megumi Oda, Atsushi Sato and for the Japan Association of Childhood Leukemia Study (JACLS) & Children's Cancer and Leukemia Study Group (CCLSG)

      Article first published online: 28 FEB 2014 | DOI: 10.1002/cam4.221

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      This study reviewed the clinical characteristics of 112 pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL) patients with TCF3-PBX1 fusion treated according to the Japan Association of Childhood Leukemia Study (JACLS) ALL02 and Children's Cancer and Leukemia Study Group (CCLSG) ALL 2004 protocol. Conventional prognostic factors such as age at onset, initial white blood cell count, and National Cancer Institute risk have no impact on prognosis. Interestingly, the two patients with IKZF1 deletion eventually relapsed, as did one patient in the independent cohort of 22 BCP-ALL patients with TCF3-PBX1 fusion CCLSG ALL 2004 protocol who harbored the IKZF1 deletion.

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      Risk-stratified patients with resectable soft tissue sarcoma benefit from epirubicin-based adjuvant chemotherapy

      Aaron D. Schenone, Jingqin Luo, Luke Montgomery, Daniel Morgensztern, Douglas R. Adkins and Brian A. Van Tine

      Article first published online: 27 FEB 2014 | DOI: 10.1002/cam4.209

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      We retrospectively analyzed the effect of adjuvant epirubicin and ifosfamide in a cohort of sarcoma patients. In order to analyze patient survival, we risk stratified patients using the Memorial Sloan Kettering Sarcoma prognostic nomogram and then applied the Inverse Probability of Treatment Weighting statistical method to identify the patients who benefited from adjuvant chemotherapy.

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      Comparison of dynamic contrast-enhanced MR, ultrasound and optical imaging modalities to evaluate the antiangiogenic effect of PF-03084014 and sunitinib

      Cathy C. Zhang, Zhengming Yan, Anand Giddabasappa, Patrick B. Lappin, Cory L. Painter, Qin Zhang, Gang Li, James Goodman, Brett Simmons, Bernadette Pascual, Joseph Lee, Ted Levkoff, Tim Nichols and Zhiyong Xie

      Article first published online: 27 FEB 2014 | DOI: 10.1002/cam4.215

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      We compared different imaging modalities to monitor the vasculature changes in breast cancer xenograft model after the treatment of PF-03084014. Sunitinib served as a comparator to potentially bridge the findings between the clinical and nonclinical settings. This work provides insights into the applications of the imaging technology in the cancer drug discovery process.

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      Copy number increase of ACTN4 is a prognostic indicator in salivary gland carcinoma

      Yukio Watabe, Taisuke Mori, Seiichi Yoshimoto, Takeshi Nomura, Takahiko Shibahara, Tesshi Yamada and Kazufumi Honda

      Article first published online: 27 FEB 2014 | DOI: 10.1002/cam4.214

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      Copy number increase (CNI) of ACTN4 has been associated with poor prognosis and metastatic phenotypes in various human carcinomas. The patients with CNI of ACTN4 had a significantly worse prognosis than the patients with normal copy number of ACTN4 (P = 0.0005 log-rank test). CNI of ACTN4 is a novel indicator for an unfavorable outcome in patients with salivary gland carcinoma .

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      Modulation of circulating protein biomarkers following TRC105 (anti-endoglin antibody) treatment in patients with advanced cancer

      Yingmiao Liu, Mark D. Starr, John C. Brady, Andrew Dellinger, Herbert Pang, Bonne Adams, Charles P. Theuer, Nam Y. Lee, Herbert I. Hurwitz and Andrew B. Nixon

      Article first published online: 14 FEB 2014 | DOI: 10.1002/cam4.207

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      Biomarker changes were detected in cancer patients receiving TRC105. Soluble endoglin was found to significantly increase in a TRC105 dose-dependent manner, likely representing a direct drug effect. Overall biomarker changing pattern in response to TRC105 is distinct from that to bevacizumab, suggesting TRC105 targets a VEGF-independent pathway and advocating the combination of both drugs.

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      Response assessment of NovoTTF-100A versus best physician's choice chemotherapy in recurrent glioblastoma

      Eric T. Wong, Edwin Lok, Kenneth D. Swanson, Shiva Gautam, Herbert H. Engelhard, Frank Lieberman, Sophie Taillibert, Zvi Ram and John L. Villano

      Article first published online: 14 FEB 2014 | DOI: 10.1002/cam4.210

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      The hazard functions for tumor progression in responders and nonresponders. In the NovoTTF-100A cohort, the peak hazard rate for responders is lower than that for nonresponders, while the reverse is seen in the Best Physician's Choice (BPC) chemotherapy cohort. The time of peak hazard rate is delayed in responders compared to nonresponders in both cohorts.

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      Phase II trial of sorafenib and erlotinib in advanced pancreatic cancer

      Dana B. Cardin, Laura Goff, Chung-I Li, Yu Shyr, Charles Winkler, Russell DeVore, Larry Schlabach, Melanie Holloway, Pam McClanahan, Krista Meyer, Julia Grigorieva, Jordan Berlin and Emily Chan

      Article first published online: 12 FEB 2014 | DOI: 10.1002/cam4.208

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      This trial was designed to assess efficacy and safety of sorafenib with erlotinib in the treatment of patients with advanced pancreatic adenocarcinoma. An exploratory correlative study analyzing pretreatment serum samples using a multivariate protein mass spectrometry-based test, previously shown to correlate with outcomes in lung cancer patients treated with erlotinib, was performed. Patients received sorafenib 400 mg daily along with erlotinib 150 mg daily with a primary endpoint of 8-week progression-free survival (PFS) rate.

    10. You have full text access to this OnlineOpen article
      Gamma Knife radiosurgery to four or more brain metastases in patients without prior intracranial radiation or surgery

      Eric Ojerholm, John Y. K. Lee, James Kolker, Robert Lustig, Jay F. Dorsey and Michelle Alonso-Basanta

      Article first published online: 10 FEB 2014 | DOI: 10.1002/cam4.206

      Thumbnail image of graphical abstract

      Gamma Knife radiosurgery as sole initial treatment for four or more simultaneous metastases spares some patients whole-brain radiation therapy and delays it for others. Increased total tumor volume (≥3 cc) is significantly associated with worsened overall survival.

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