Cancer Medicine

Cover image for Vol. 5 Issue 5

Early View (Online Version of Record published before inclusion in an issue)

Edited By: Qingyi Wei, M.D., Ph.D.

Impact Factor: 2.5

ISI Journal Citation Reports © Ranking: 2014: 121/211 (Oncology)

Online ISSN: 2045-7634

VIEW

  1. 1 - 85
  1. Original Research

    1. You have full text access to this OnlineOpen article
      Reduction in squamous cell carcinomas in mouse skin by dietary zinc supplementation

      Jin Sun, Rulong Shen, Morgan S. Schrock, James Liu, Xueliang Pan, Donald Quimby, Nicola Zanesi, Teresa Druck, Louise Y. Fong and Kay Huebner

      Version of Record online: 17 MAY 2016 | DOI: 10.1002/cam4.768

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      Zn supplementation can suppress tumor formation in rodent models. To determine if it could suppress development of nonmelanoma skin cancers, the most common cancer in humans, occurring with high frequency and morbidity in patients, we induced skin papillomas and squamous cell carcinoma (SCCs) in mice by carcinogen treatment. Zn supplementation suppressed the frequency of SCCs in both sexes of two mouse strains, suggesting that Zn supplementation should be tested for prevention of SCCs in high-risk humans.

    2. You have full text access to this OnlineOpen article
      An examination of racial differences in 5-year survival of cervical cancer among African American and white American women in the southeastern US from 1985 to 2010

      Janaka Weragoda, Andres Azuero, Suguna Badiga, Walter C. Bell, Roland Matthews and Chandrika Piyathilake

      Version of Record online: 17 MAY 2016 | DOI: 10.1002/cam4.765

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      We did not observe strong evidence for racial differences in survival of cervical cancer. The study suggests that the age at diagnosis, cancer stage, mode of treatment, and histological subtype are the most salient characteristics predicting 5-year survival.

    3. You have full text access to this OnlineOpen article
      Expressions of SH3BP5, LMO3, and SNAP25 in diffuse large B-cell lymphoma cells and their association with clinical features

      Kyoko Kobayashi, Motoko Yamaguchi, Kana Miyazaki, Hiroshi Imai, Kaori Yokoe, Ryoichi Ono, Tetsuya Nosaka and Naoyuki Katayama

      Version of Record online: 17 MAY 2016 | DOI: 10.1002/cam4.753

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      DLBCL cells can express SH3BP5, LMO3, and SNAP25 proteins. The SH3BP5 and LMO3 protein expressions are associated with clinical features of DLBCL patients.

    4. You have full text access to this OnlineOpen article
      High expression of integrin β6 in association with the Rho–Rac pathway identifies a poor prognostic subgroup within HER2 amplified breast cancers

      Krisha Desai, Madhumathy G. Nair, Jyothi S. Prabhu, Anupama Vinod, Aruna Korlimarla, Savitha Rajarajan, Radhika Aiyappa, Rohini S. Kaluve, Annie Alexander, P. S. Hari, Geetashree Mukherjee, Rekha V. Kumar, Suraj Manjunath, Marjorrie Correa, B. S. Srinath, Shekhar Patil, M. S. N. Prasad, K. S. Gopinath, Raman N. Rao, Shelia M. Violette, Paul H. Weinreb and T. S. Sridhar

      Version of Record online: 17 MAY 2016 | DOI: 10.1002/cam4.756

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      The evidence for the involvement of αvβ6 integrin in the progression of breast cancer rests on data from two large European cohorts of patients. However, the identity of the downstream pathways involved is unclear. We have used two independent case series (N = 460) and have confirmed the observations of Moore et al. More importantly, we have found supporting evidence for the activation of the Rho–Rac pathway in HER2+ patients with elevated levels of ITGB6 expression.

    5. You have full text access to this OnlineOpen article
      Fascin-1 as a novel diagnostic marker of triple-negative breast cancer

      Chao-Qun Wang, Chih-Hsin Tang, Hao-Teng Chang, Xiao-Ni Li, Yong-Ming Zhao, Chen-Ming Su, Gui-Nv Hu, Tao Zhang, Xin-Xin Sun, Yue Zeng, Zhang Du, Yan Wang and Bi-Fei Huang

      Version of Record online: 17 MAY 2016 | DOI: 10.1002/cam4.746

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      A new scoring criterion for strong positive fascin-1 expression is proposed. A comparison between strong positive fascin-1 expression and fluorescence in situ hybridization (FISH) analysis was carried out. Strong positive fascin-1 expression has high sensitivity and specificity for predicting triple-negative breast cancer (TNBC).

    6. You have full text access to this OnlineOpen article
      BET and BRAF inhibitors act synergistically against BRAF-mutant melanoma

      Luca Paoluzzi, Douglas Hanniford, Elena Sokolova, Iman Osman, Farbod Darvishian, Jinhua Wang, James E. Bradner and Eva Hernando

      Version of Record online: 11 MAY 2016 | DOI: 10.1002/cam4.667

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      We believe that the combination of BRAF inhibitors with new epigenetic drugs such as Bromodomain and extraterminal domain (BET) inhibitors offers a unique chance for the development of novel treatment programs for challenging malignancies such as melanoma.

    7. You have full text access to this OnlineOpen article
      Genome-wide analysis of long noncoding RNA (lncRNA) expression in colorectal cancer tissues from patients with liver metastasis

      Dong Chen, Qiang Sun, Xiaofei Cheng, Lufei Zhang, Wei Song, Dongkai Zhou, Jianjiang Lin and Weilin Wang

      Version of Record online: 11 MAY 2016 | DOI: 10.1002/cam4.738

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      Although the biological and pathological functions of most lncRNAs are still unclear, there is increasing evidence that many long noncoding RNA (lncRNAs) play significant roles in the regulation of colorectal cancer (CRC). We examined differentially expressed lncRNAs and mRNAs in tissues obtained from CRC patients with liver metastasis and without any metastasis, to identify novel diagnostic and prognostic markers.

    8. You have full text access to this OnlineOpen article
      A novel histologic grading scheme based on poorly differentiated clusters is applicable to treated rectal cancer and is associated with established histopathological prognosticators

      Michelle Yang, Aseeb Ur Rehman, Chunlai Zuo, Christine E. Sheehan, Edward C Lee, Jingmei Lin, Zijin Zhao, Euna Choi and Hwajeong Lee

      Version of Record online: 11 MAY 2016 | DOI: 10.1002/cam4.740

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      This study employed the use of a novel histologic grading system independent of gland formation to discover its positive correlation with known histopathological prognosticators in treated rectal cancer.

    9. You have full text access to this OnlineOpen article
      Proton beam therapy for pediatric malignancies: a retrospective observational multicenter study in Japan

      Masashi Mizumoto, Shigeyuki Murayama, Tetsuo Akimoto, Yusuke Demizu, Takashi Fukushima, Yuji Ishida, Yoshiko Oshiro, Haruko Numajiri, Hiroshi Fuji, Toshiyuki Okumura, Hiroki Shirato and Hideyuki Sakurai

      Version of Record online: 11 MAY 2016 | DOI: 10.1002/cam4.743

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      The effects of proton beam therapy (PBT) were examined in 343 pediatric patients treated at four sites in Japan from 1983 to 2014. The median follow-up period was 22.6 months. The 1-, 3-, 5-, and 10-year survival rates were 82.7%, 67.4%, 61.4%, and 58.7%, respectively. There were 52 events of toxicity ≥ grade 2 in 43 patients. Grade 4 toxicities occurred in only five patients. These results suggest that PBT is safe in pediatric patients.

    10. You have full text access to this OnlineOpen article
      Detection of somatic BRCA1/2 mutations in ovarian cancer – next-generation sequencing analysis of 100 cases

      Koczkowska Magdalena, Zuk Monika, Gorczynski Adam, Ratajska Magdalena, Lewandowska Marzena, Biernat Wojciech, Limon Janusz and Wasag Bartosz

      Version of Record online: 11 MAY 2016 | DOI: 10.1002/cam4.748

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      The use of a tumor sample for molecular analysis and further mutational analysis of the entire coding sequence of both BRCA1 and BRCA2 may significantly increase the total number of patients who may potentially benefit from the targeted therapies with PARP inhibitors. In addition, such a genetic testing would allow to identify more family members with BRCA1/2 mutations.

    11. You have full text access to this OnlineOpen article
      Photoimmunotherapy of residual disease after incomplete surgical resection in head and neck cancer models

      Lindsay S. Moore, Esther de Boer, Jason M. Warram, Matthew D. Tucker, William R. Carroll, Melissa L. Korb, Margaret S. Brandwein-Gensler, Gooitzen M. van Dam and Eben L. Rosenthal

      Version of Record online: 11 MAY 2016 | DOI: 10.1002/cam4.752

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      Photoimmunotherapy (PIT) is a novel, cancer-targeted technology with the potential to induce phototoxic damage to tumor cells while sparing precious adjacent normal tissue. Given the ability of PIT agents to be used as dual diagnostic and therapeutic agents, many experts believe that this modality would be best used to eradicate residual microscopic disease after incomplete surgical resection; however, most existing studies in this field use whole-tumor animal models. In order to assess the therapeutic potential of PIT in the proposed role of an adjuvant post-surgical treatment modality, we designed novel in vitro and in vivo models of microscopic and residual disease, as well as obtained fresh human tissue to assess the clinical translatability of this technology.

    12. You have full text access to this OnlineOpen article
      A new simple morphology-based risk score is prognostic in stage I/II colon cancers

      Bruno Märkl, Maximilian Märkl, Tina Schaller, Patrick Mayr, Gerhard Schenkirsch, Bernadette Kriening and Matthias Anthuber

      Version of Record online: 11 MAY 2016 | DOI: 10.1002/cam4.737

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      A morphology-based risk (MBR) score facilitates a stratification of stage I/II colon cancers into three prognostically different groups. It identifies 18% cases of stage II cancers with adverse clinical course, and superior to microsatellite status and NCCN risk stratification.

    13. You have full text access to this OnlineOpen article
      Targeting immune checkpoints in unresectable metastatic cutaneous melanoma: a systematic review and meta-analysis of anti-CTLA-4 and anti-PD-1 agents trials

      Seongseok Yun, Nicole D. Vincelette, Myke R. Green, Andrea E. Wahner Hendrickson and Ivo Abraham

      Version of Record online: 11 MAY 2016 | DOI: 10.1002/cam4.732

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      The efficacy of immune check point inhibitors in previous randomized trials with cutaneous metastatic melanoma patients showed consistent outcomes, however, the degree of benefit varied across studies. In the meta-analysis of six randomized trials, we showed the significant benefit of immune check point inhibitors as a category over conventional therapy and the superiority of anti-PD-1 over anti-CTLA-4 (cytotoxic T lymphocyte-associated antigen-4) agents.

  2. Commentary

    1. You have full text access to this OnlineOpen article
      The Wilms’ tumor (WT1) gene expression correlates with the International Prognostic Scoring System (IPSS) score in patients with myelofibrosis and it is a marker of response to therapy

      Daniela Gallo, Paolo Nicoli, Chiara Calabrese, Valentina Gaidano, Jessica Petiti, Valentina Rosso, Elisabetta Signorino, Sonia Carturan, Giada Bot-Sartor, Gisella Volpe, Francesco Frassoni, Giuseppe Saglio and Daniela Cilloni

      Version of Record online: 11 MAY 2016 | DOI: 10.1002/cam4.735

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      Although myelofibrosis is characterized by mutations of JAk2 and calreticulin (CALR), these mutations are not useful to monitor response to therapy. WT1 correlates with the International Prognostic Scoring System (IPSS) score at diagnosis. WT1 is a good marker for monitoring the response to therapy.

  3. Original Research

    1. You have full text access to this OnlineOpen article
      Effects of psychological interventions and patients' affect on short-term quality of life in patients undergoing colorectal surgery

      Gerold Koplin, Verena Müller, Grit Heise, Johann Pratschke, Wolfgang Schwenk and Oliver Haase

      Version of Record online: 3 MAY 2016 | DOI: 10.1002/cam4.739

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      The EORTC, Gastrointestinal Quality of life Index and PANAS questionnaires were used to examine 60 patients undergoing colorectal resection to identify changes in postoperative quality of life and determine the influence of perioperative applied psychological interventions. Neither Guided Imagery nor Progressive Relaxation was influencing short-term QoL Screening patients' with the PANAS questionnaire might help to identify individuals that are more likely to have a worse QoL postoperatively.

    2. You have full text access to this OnlineOpen article
      Fatty acid synthase regulates invasion and metastasis of colorectal cancer via Wnt signaling pathway

      Haiyu Wang, Qiulei Xi and Guohao Wu

      Version of Record online: 3 MAY 2016 | DOI: 10.1002/cam4.711

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      In this study, we depicted that fatty acid synthase (Fasn) expression was elevated in human colorectal cancer (CRC), which accordingly led to lymphatic and distant metastasis and a more advanced clinical phenotype. Further mechanical exploration revealed that Fasn knockdown could attenuate Wnt signaling pathway via downregulating distinctive genes, namely Wnt5a, Wnt5b, Fzd2, which at least partly contributed to the decrease in metastasis.

    3. You have full text access to this OnlineOpen article
      Human 3β-hydroxysteroid dehydrogenase type 1 in human breast cancer: clinical significance and prognostic associations

      Toru Hanamura, Tokiko Ito, Toshiharu Kanai, Kazuma Maeno, Yasuyo Shimojo, Takeshi Uehara, Takashi Suzuki, Shin-ichi Hayashi and Ken-ichi Ito

      Version of Record online: 3 MAY 2016 | DOI: 10.1002/cam4.708

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      In this study, we applied immunohistochemistry (IHC) to investigate the clinical and prognostic significance of 3β-HSD type 1, which may regulate in situ production or inactivation of active sex steroids in hormone-dependent breast cancers. This is the first study to indicate that 3β-HSD type 1 is potent prognostic factor in hormone-dependent breast cancer.

    4. You have full text access to this OnlineOpen article
      Lack of health maintenance examinations and risk in myeloma patients

      Joseph D. Tariman, Charise Gleason, Beth Faiman, Deborah Doss, Donna Catamero, Jessica Bishop-Royse, Mike Katz, Sandra Kurtin, Diane Moran, The IMF Nurse Leadership Board and Sagar Lonial

      Version of Record online: 27 APR 2016 | DOI: 10.1002/cam4.716

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      Patients with MM, particularly men, require continued education and close monitoring of health maintenance practices. Healthcare providers must incorporate health maintenance promotion during routine clinic visits.

    5. You have full text access to this OnlineOpen article
      Real-world treatment practice in patients with advanced melanoma in the era before ipilimumab: results from the IMAGE study

      Mark R. Middleton, Stéphane Dalle, Joel Claveau, Pilar Mut, Sigrun Hallmeyer, Patrice Plantin, Martin Highley, Srividya Kotapati, Trong Kim Le, Jane Brokaw and Amy P. Abernethy

      Version of Record online: 26 APR 2016 | DOI: 10.1002/cam4.717

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      The IMAGE (ipilimumab: management of advanced melanoma in real practice; ClinicalTrials.gov Identifier: NCT01511913) study is a multi-site, observational study evaluating real-world treatment and patient outcomes for advanced melanoma, both prospectively and retrospectively. Results from the retrospective cohort, which was treated in the era before the immuno-oncology agent ipilimumab, confirm the previous unmet need in advanced melanoma and provide historical information to facilitate the assessment of recent treatment patterns and trends in advanced melanoma.

    6. You have full text access to this OnlineOpen article
      Retrospective analysis of bevacizumab-induced hypertension and clinical outcome in patients with colorectal cancer and lung cancer

      Aya Nakaya, Takayasu Kurata, Takashi Yokoi, Shigeyoshi Iwamoto, Yoshitaro Torii, Yuichi Katashiba, Makoto Ogata, Madoka Hamada, Masanori Kon and Shosaku Nomura

      Version of Record online: 25 APR 2016 | DOI: 10.1002/cam4.701

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      The most common bevacizumab-related adverse event was hypertension. Patients who developed hypertension during treatment with bevacizumab for colorectal cancer and non-small lung cancer had significantly prolonged overall survival.

    7. You have full text access to this OnlineOpen article
      Flow cytometry-based characterization of underlying clonal B and plasma cells in patients with light chain amyloidosis

      Katharina Lisenko, Stefan O. Schönland, Anna Jauch, Mindaugas Andrulis, Christoph Röcken, Anthony D. Ho, Hartmut Goldschmidt, Ute Hegenbart and Michael Hundemer

      Version of Record online: 25 APR 2016 | DOI: 10.1002/cam4.725

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      Systemic amyloid light chain (AL) amyloidosis is a life-threatening protein deposition disorder and an accurate diagnosis of the underlying hematologic disease is important to provide effective therapy. We analyzed the presence of clonal plasma cell (PC) and B cells in the bone marrow of 63 patients with newly diagnosed AL-amyloidosis by multi-parameter flow cytometry (MFC). MFC identified underlying clonal lymphatic cells in all but two patients (61 of 63, 97%). Sixty-one patients harbored malignant PCs, whereas B-cell lymphomas were identified in two patients. These results demonstrate that MFC is a reliable tool for an accurate diagnosis of the underlying hematologic disease in patients with AL amyloidosis.

    8. You have full text access to this OnlineOpen article
      Adherence to cancer screening guidelines in Australian survivors of allogeneic blood and marrow transplantation (BMT)

      Gemma Dyer, Stephen R. Larsen, Nicole Gilroy, Lisa Brice, Matt Greenwood, Mark Hertzberg, Masura Kabir, Louisa Brown, Megan Hogg, Gillian Huang, John Moore, David Gottlieb, John Kwan, Jeff Tan, Christopher Ward and Ian Kerridge

      Version of Record online: 25 APR 2016 | DOI: 10.1002/cam4.729

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      We conducted a cross-sectional survey of 441 Blood and Marrow Transplant (BMT) survivors who were >1 year post transplant, to explore rates of screening for secondary cancers and to identify barriers to adherence with cancer screening recommendations. Rates of cancer screening uptake were as follows: cervical 63.4%, breast 53.3%, skin 52.4%, and bowel 32.3%. Improved quality of life was associated with screening for skin, breast, and cervical cancer. Fear of cancer recurrence negatively impacted on cervical screening. For those who had not undergone screening, the majority reported not being advised to do so by their treatment team.

    9. You have full text access to this OnlineOpen article
      Are parenting behaviors associated with child sleep problems during treatment for acute lymphoblastic leukemia?

      Maria C. McCarthy, Jessica Bastiani and Lauren K. Williams

      Version of Record online: 25 APR 2016 | DOI: 10.1002/cam4.727

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      This study examined sleep problems in children undergoing treatment for acute lymphoblastic leukemia (ALL) compared to healthy children and whether parenting practices are associated with sleep difficulties. Parents of children with ALL reported significantly more child sleep problems and parent–child co-sleeping was significantly associated with child sleep difficulties. Strategies employed by parents during ALL treatment may be a potential modifiable intervention target that could result in improved child quality of life.

    10. You have full text access to this OnlineOpen article
      Circulating CD14+HLA-DR-/low myeloid-derived suppressor cells in leukemia patients with allogeneic hematopoietic stem cell transplantation: novel clinical potential strategies for the prevention and cellular therapy of graft-versus-host disease

      Jin Yin, Chunyan Wang, Min Huang, Xia Mao, Jianfeng Zhou and Yicheng Zhang

      Version of Record online: 25 APR 2016 | DOI: 10.1002/cam4.688

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      This study revealed that MDSCs might be considered as a novel prognostic factor in patients with allo-HSCT and potential new approaches to regulate transplant rejection and achieve the recipient host long-term acceptance and survival. The understanding of the activation and differentiation of MDSCs in human will help to develop inhibitors during their unwanted activity, such as preventing relapse, but also provide options for therapeutical intervention in aGVHD after allo-HSCT.

    11. You have full text access to this OnlineOpen article
      Prognostic microRNA signatures derived from The Cancer Genome Atlas for head and neck squamous cell carcinomas

      Nathan Wong, Shariq S. Khwaja, Callie M. Baker, Hiram A. Gay, Wade L. Thorstad, Mackenzie D. Daly, James S. Lewis Jr and Xiaowei Wang

      Version of Record online: 25 APR 2016 | DOI: 10.1002/cam4.718

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      Prognostic microRNA signatures were identified for head and neck cancers by analysis of public profiling data from The Cancer Genome Atlas (TCGA). This work demonstrates the power of using TCGA as a potential resource to develop prognostic tools for improving individualized patient care.

    12. You have full text access to this OnlineOpen article
      Phase II evaluation of sunitinib in the treatment of recurrent or refractory high-grade glioma or ependymoma in children: a children's Oncology Group Study ACNS1021

      Cynthia Wetmore, Vinay M. Daryani, Catherine A. Billups, James M. Boyett, Sarah Leary, Rachel Tanos, Kelly C. Goldsmith, Clinton F. Stewart, Susan M. Blaney and Amar Gajjar

      Version of Record online: 25 APR 2016 | DOI: 10.1002/cam4.713

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      This Phase II study of sunitinib reports the safety, tolerability and pharmacokinetic disposition in pediatric patients with recurrent high-grade glioma and ependymoma. While there was sufficient level of sunitinib in peripheral blood to modulate plasma vascular endothelial growth factor receptor (VEGFR)2, there were no sustained responses and no single agent activity in this patient cohort.

    13. You have full text access to this OnlineOpen article
      Breast cancer screening disparities among immigrant women by world region of origin: a population-based study in Ontario, Canada

      Mandana Vahabi, Aisha Lofters, Matthew Kumar and Richard H. Glazier

      Version of Record online: 22 APR 2016 | DOI: 10.1002/cam4.700

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      The study found differences in rates of breast cancer screening among Ontario immigrant women by world region of origin. South Asian women had the lowest cancer screening rates. Factors associated with lower screening included living in the lowest income neighborhoods, having a refugee status, being a new immigrant, not having a regular physical examination, not being enrolled in a primary care patient enrollment model, having a male physician, and having an internationally trained physician.

    14. You have full text access to this OnlineOpen article
      Subsequent primary malignancies and acute myelogenous leukemia transformation among myelodysplastic syndrome patients treated with or without lenalidomide

      Dana E. Rollison, Kenneth H. Shain, Ji-Hyun Lee, Shalaka S. Hampras, William Fulp, Kate Fisher, Najla H. Al Ali, Eric Padron, Jeffrey Lancet, Qiang Xu, Martha Olesnyckyj, Laurie Kenvin, Robert Knight, William Dalton, Alan List and Rami S. Komrokji

      Version of Record online: 20 APR 2016 | DOI: 10.1002/cam4.721

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      In a retrospective cohort study of myelodysplastic syndrome (MDS) patients (n = 1248), conducted at Moffitt Cancer Center, lenalidomide was not associated with subsequent primary malignancies (SPMs) incidence in the MDS cohort (HR = 1.04, 95% CI = 0.40–2.74), whereas a significantly reduced SPM risk was observed in the case–control sample (OR = 0.03, 95% CI = <0.01–0.63). Lenalidomide was not associated with acute myeloid leukemia (AML) transformation in the cohort analysis (HR = 0.75, 95% CI = 0.44–1.27) or in the case–control analyses (OR = 1.16, 95% CI = 0.52–2.56), after adjustment for potential confounders. In conclusion, lenalidomide was not associated with increased risk of SPM or AML transformation in a large cohort of MDS patients mostly including nondeletion 5q MDS.

    15. You have full text access to this OnlineOpen article
      HuR-regulated lncRNA NEAT1 stability in tumorigenesis and progression of ovarian cancer

      Yiqing Chai, Jie Liu, Zhikun Zhang and Liwei Liu

      Version of Record online: 14 APR 2016 | DOI: 10.1002/cam4.710

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      LncRNA NEAT1, whose expression was collaboratively controlled by HuR and miR-124-3p, could regulate ovarian carcinogenesis and may serve as a potential target for antineoplastic therapies.

    16. You have full text access to this OnlineOpen article
      A phase I study of the human anti-activin receptor-like kinase 1 antibody PF-03446962 in Asian patients with advanced solid tumors

      Toshihiko Doi, Kyung-Hun Lee, Tae-Min Kim, Atsushi Ohtsu, Tae Yong Kim, Masafumi Ikeda, Kiyotaka Yoh, Corrado Gallo Stampino, Tomoko Hirohashi, Akiyuki Suzuki, Yosuke Fujii, James Andrew Williams and Yung-Jue Bang

      Version of Record online: 14 APR 2016 | DOI: 10.1002/cam4.724

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      This report presents the safety, preliminary activity, and pharmacokinetics results of the first study of the novel anti-activin receptor-like kinase 1 (ALK-1) monoclonal antibody PF-03446962 in Asian patients with advanced solid tumors. The study findings suggest that activin receptor-like kinase-1 (ALK-1) inhibition by PF-03446962 may represent a novel antiangiogenic strategy for patients with advanced solid malignancies, complementary to vascular endothelial growth factor (receptor)-targeted therapy or chemotherapy.

    17. You have full text access to this OnlineOpen article
      Hepatitis B virus mutations, expression quantitative trait loci for PTPN12, and their interactions in hepatocellular carcinoma

      Ci Song, Yao Liu, Lu Xu, Juan Wen, Deke Jiang, Jianguo Chen, Xiangjun Zhai, Zhibin Hu, Li Liu and Jibin Liu

      Version of Record online: 14 APR 2016 | DOI: 10.1002/cam4.712

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      PTPN12 may influence HCC risk accompanied by HBV mutations.

  4. Commentary

    1. You have full text access to this OnlineOpen article
      Moving survivorship care plans forward: focus on care coordination

      Talya Salz and Shrujal Baxi

      Version of Record online: 14 APR 2016 | DOI: 10.1002/cam4.733

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      Five randomized controlled trials of the effectiveness of survivorship care plans have yielded null results. We propose that these trials failed to account for whether survivorship care plans improved the critical outcome of care coordination, and we propose four criteria for future studies that will improve the quality of the evidence base.

  5. Original Research

    1. You have full text access to this OnlineOpen article
      Organotypic slice cultures of human gastric and esophagogastric junction cancer

      Justus Koerfer, Sonja Kallendrusch, Felicitas Merz, Christian Wittekind, Christoph Kubick, Woubet T. Kassahun, Guido Schumacher, Christian Moebius, Nikolaus Gaßler, Nikolas Schopow, Daniela Geister, Volker Wiechmann, Arved Weimann, Christian Eckmann, Achim Aigner, Ingo Bechmann and Florian Lordick

      Version of Record online: 12 APR 2016 | DOI: 10.1002/cam4.720

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      Gastric and esophagogastric junction cancer was cultured in slices ex vivo. Slice cultures revealed a good morphological preservation up to 6 days and tumor cellularity decreased significantly following cytotoxic treatment in vitro. Individual response to chemotherapy can be observed in human tumor slices cultures.

    2. You have full text access to this OnlineOpen article
      AKT1 and BRAF mutations in pediatric aggressive fibromatosis

      Cristina Meazza, Antonino Belfiore, Adele Busico, Giulio Settanni, Nicholas Paielli, Luca Cesana, Andrea Ferrari, Stefano Chiaravalli, Maura Massimino, Alessandro Gronchi, Chiara Colombo, Silvana Pilotti and Federica Perrone

      Version of Record online: 8 APR 2016 | DOI: 10.1002/cam4.669

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      The aim of this study was to shed more light on the mutational spectrum of 28 pediatric aggressive fibromatosis (AF), comparing it with its adult counterpart. In addition to CTNNB1 mutation (64%), pediatric AF showed AKT1 (31%), BRAF (19%), and TP53 (9%) mutations, whereas only the CTNNB1 mutation was found in 33 adult AF. This intriguing finding, suggesting a mutational spectrum of pediatric AF more complex than that of adult, may have clinical implications and warrants further investigations.

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      Intraoperative frozen section analysis of the proximal bile ducts in hilar cholangiocarcinoma is of limited value

      Hendrik T.J. Mantel, Andrie C. Westerkamp, Egbert Sieders, Paul M. J. G. Peeters, Koert P. de Jong, Marieke T. Boer, Ruben H. de Kleine, Annette S. H. Gouw and Robert J. Porte

      Version of Record online: 6 APR 2016 | DOI: 10.1002/cam4.693

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      The use of intraoperative frozen section analysis of the proximal bile duct in hilar cholangiocarcinoma is of limited clinical value because of the relatively low sensitivity, high risk of false-negative results, and the low rate of secondary obtained tumor-free resection margins. The technique should be reserved for those cases only in which a substantial additional resection is possible.

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      CD8+ tumor-infiltrating lymphocytes contribute to spontaneous “healing” in HER2-positive ductal carcinoma in situ

      Michi Morita, Rin Yamaguchi, Maki Tanaka, Gary M. Tse, Miki Yamaguchi, Naoki Kanomata, Yoshiki Naito, Jun Akiba, Satoshi Hattori, Shigeki Minami, Susumu Eguchi and Hirohisa Yano

      Version of Record online: 6 APR 2016 | DOI: 10.1002/cam4.715

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      We evaluated the spontaneous “healing” phenomenon in ductal carcinoma in situ (DCIS) and its association with tumor-infiltrating lymphocytes (TIL) including CD8 positive lymphocytes. Spontaneous “healing” may be attributable to CD8+ high-TIL associated with high -grade, comedo necrosis, apocrine features, and HER2-positive DCIS.

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      Regulation of multidrug resistance 1 expression by CDX2 in ovarian mucinous adenocarcinoma

      Iemasa Koh, Takao Hinoi, Kazuhiro Sentani, Eiji Hirata, Suguru Nosaka, Hiroaki Niitsu, Masashi Miguchi, Tomohiro Adachi, Wataru Yasui, Hideki Ohdan and Yoshiki Kudo

      Version of Record online: 6 APR 2016 | DOI: 10.1002/cam4.697

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      Resistance against chemotherapeutic agents often develops in ovarian cancer patients, contributing to high recurrence rates. We hypothesized that profiling of CDX2 and MDR1 expression could be an effective strategy for predicting anticancer drug resistance. Here, we demonstrate that CDX2 promotes upregulation of MDR1 expression leading to drug resistance in ovarian mucinous adenocarcinoma. Our findings have direct clinical implications regarding the development of novel therapeutic strategies for ovarian cancer based on CDX2 status.

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      Dermal fibroblasts induce cell cycle arrest and block epithelial–mesenchymal transition to inhibit the early stage melanoma development

      Linli Zhou, Kun Yang, R. Randall Wickett and Yuhang Zhang

      Version of Record online: 6 APR 2016 | DOI: 10.1002/cam4.707

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      We developed a novel genetic approach to deactivate stromal fibroblasts in vivo to determine their role and functions at the onset of melanoma formation. Our findings clearly suggest that dermal fibroblasts defend against melanoma during early stages of tumor formation by inducing a cell cycle arrest, partially through MAPK/ERK and pRB pathways, and blocking epithelial-mesenchymal transition in melanoma cells.

    7. You have full text access to this OnlineOpen article
      Elevated microsatellite alterations at selected tetranucleotides in early-stage colorectal cancers with and without high-frequency microsatellite instability: same, same but different?

      Martin M. Watson, Dordi Lea, Emma Rewcastle, Hanne R. Hagland and Kjetil Søreide

      Version of Record online: 6 APR 2016 | DOI: 10.1002/cam4.709

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      Elevated microsatellite alterations at selected tetranucleotides (EMAST) is a form of microsatellite instability that occurs in up to a quarter of colorectal cancers without traditional microsatellite instability (MSI). Presence of EMAST was not prognostic in this cohort of early colorectal cancer (CRC). A trend toward reduced cancer-specific survival was found for stage II colon cancers with EMAST.

    8. You have full text access to this OnlineOpen article
      GABABR/GSK-3β/NF-κB signaling pathway regulates the proliferation of colorectal cancer cells

      Qing Shu, Jun Liu, Xiupeng Liu, Sufang Zhao, Hualin Li, Yonggang Tan and Jianming Xu

      Version of Record online: 5 APR 2016 | DOI: 10.1002/cam4.686

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      Activation of γ-Aminobutyric acid receptor (GABABR) signaling significantly inhibited the colorectal cell HT29 proliferation by arresting the cell at G1 phase. Inhibition of GABABR could activate GSK-3β by reducing the phosphorylation level of GSK-3β, moreover, activation of GSK-3β blocked the repression of cell proliferation caused by inhibition of GABABR signaling. Activation of GABABR leaded to inhibition of GSK-3β activation to repress the NF-κB function during colorectal cancer cell proliferation.

  6. Short Reports

    1. You have full text access to this OnlineOpen article
      AGK-BRAF gene fusion is a recurrent event in sporadic pediatric thyroid carcinoma

      Maria Isabel C. V. Cordioli, Lais Moraes, Gianna Carvalheira, Luiza Sisdelli, Maria Teresa S. Alves, Rosana Delcelo, Osmar Monte, Carlos A. Longui, Adriano N. Cury and Janete M. Cerutti

      Version of Record online: 31 MAR 2016 | DOI: 10.1002/cam4.698

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      This study described, for the first time, the presence of AGK-BRAF in sporadic pediatric PTC. Understanding the molecular events underlying pediatric PTC may improve preoperative diagnosis, allow molecular prognostication and define a therapeutic approach toward sporadic PTC patients.

  7. Commentary

    1. You have full text access to this OnlineOpen article
      The real role of pseudokinase: linking diabetes to cancers

      Ke Li and Zhuowei Hu

      Version of Record online: 31 MAR 2016 | DOI: 10.1002/cam4.706

      Thumbnail image of graphical abstract

      Pseudokinase TRIB3 has a critical role in the development of diabetes-related cancers via interacting with SQSTM1, a selective autophagy receptor. Interrupting the TRIB3-SQSTM1 interaction, using an α-helix peptide shows a significant antitumor effect both in normal and diabetic mice.

  8. Short Reports

    1. You have full text access to this OnlineOpen article
      Can metronomic maintenance with weekly vinblastine prevent early relapse/progression after bevacizumab–irinotecan in children with low-grade glioma?

      Marie Amélie Heng, Laetitia Padovani, Philippe Dory-Lautrec, Jean Claude Gentet, Arnaud Verschuur, Eddy Pasquier, Dominique Figarella-Branger, Didier Scavarda and Nicolas André

      Version of Record online: 31 MAR 2016 | DOI: 10.1002/cam4.699

      Thumbnail image of graphical abstract

      Metronomic maintenance with vinblastine after irinotecan–bevacizumab induction may prevent relapse in children with low-grade glioma.

  9. Original Research

    1. You have full text access to this OnlineOpen article
      ADH1B and ALDH2 are associated with metachronous SCC after endoscopic submucosal dissection of esophageal squamous cell carcinoma

      Kenichi Kagemoto, Yuji Urabe, Tomohiro Miwata, Shiro Oka, Hidenori Ochi, Yasuhiko Kitadai, Shinji Tanaka and Kazuaki Chayama

      Version of Record online: 31 MAR 2016 | DOI: 10.1002/cam4.705

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      The main contribution of our paper is the characteristics of esophageal squamous cell carcinoma (ESCC), and the relationship between metachronous esophageal and/or pharyngeal squamous cell carcinoma (SCC) and the ADH1B & ALDH2 risk alleles. We show that rs1229984, rs671, and smoking status are independently associated with the risk of developing metachronous SCCs. In addition, individuals with three risk factors have a 11.95-fold higher risk for metachrous SCCs than those with no or one risk factors, indicating the cumulative effects of these variations.

    2. You have full text access to this OnlineOpen article
      Development and characterization of an in vitro model of colorectal adenocarcinoma with MDR phenotype

      Lorenzo Cinci, Cristina Luceri, Elisabetta Bigagli, Ilaria Carboni, Sara Paccosi, Astrid Parenti, Daniele Guasti and Marcella Coronnello

      Version of Record online: 25 MAR 2016 | DOI: 10.1002/cam4.694

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      HCT-8/R were fully characterized by multidisciplinary approaches. These approaches allowed to highlight poorly explored features of MDR phenotype. HCT-8/R are suitable model to test novel therapeutic strategies.

    3. You have full text access to this OnlineOpen article
      Outcome of patients with nonmetastatic muscle-invasive bladder cancer not undergoing cystectomy after treatment with noncisplatin-based chemotherapy and/or radiotherapy: a retrospective analysis

      Aristotle Bamias, Petros Tsantoulis, Thomas Zilli, Athanasios Papatsoris, Francesca Caparrotti, Christos Kyratsas, Kimon Tzannis, Kostas Stravodimos, Michael Chrisofos, Gregory J. Wirth, Andreas Skolarikos, Dionysios Mitropoulos, Constantinos A. Constantinides, Charalambos Deliveliotis, Christophe E. Iselin, Raymond Miralbell, Pierre-Yves Dietrich and Meletios A. Dimopoulos

      Version of Record online: 22 MAR 2016 | DOI: 10.1002/cam4.685

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      We herein report the outcome of patients with muscle-invasive bladder cancer who did not undergo cystectomy and did not receive cisplatin-based chemotherapy as they were unfit for both treatment modalities. Treatment included transurethral resection of the tumor, radiotherapy, and carboplatin-based chemotherapy. The outcome of these patients was poor, reflecting the limited therapeutic options and the lack of clinical research focused on this population.

    4. You have full text access to this OnlineOpen article
      Improved survival time trends in Hodgkin's lymphoma

      Matthew Koshy, Andrew Fairchild, Christina H. Son and Usama Mahmood

      Version of Record online: 21 MAR 2016 | DOI: 10.1002/cam4.655

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      This population-based analysis of patients with stage I-IV Hodgkin's disease revealed a higher proportion of patients being diagnosed with stage II disease compared to earlier years. Furthermore, there was a profound improvement in survival over time for patients with Hodgkin's lymphoma which was particularly notable for those with early stage disease.

  10. Reviews

    1. You have full text access to this OnlineOpen article
      The impact of early detection and intervention of breast cancer-related lymphedema: a systematic review

      Chirag Shah, Douglas W. Arthur, David Wazer, Atif Khan, Sheila Ridner and Frank Vicini

      Version of Record online: 19 MAR 2016 | DOI: 10.1002/cam4.691

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      Increasing data supports the role of early detection and treatment of breast cancer-related lymphedema. New diagnostic modalities have increased sensitivity allowing for the earlier detection of lymphedema.

  11. Original Research

    1. You have full text access to this OnlineOpen article
      Comparison of prognoses according to non-positive and positive spectrin αII expression detected immunohistochemically in epithelial ovarian carcinoma: a retrospective study.

      Osamu Maeda, Tomoko Miyata-Takata, Kiyosumi Shibata, Hiroaki Kajiyama, Mika Mizuno, Koji Tamakoshi, Yoshie Shimoyama, Shigeo Nakamura and Fumitaka Kikkawa

      Version of Record online: 19 MAR 2016 | DOI: 10.1002/cam4.683

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      Spectrin αII expression in ovarian carcinoma surgical specimens can be scored according to the scoring criteria used in human epidermal growth factor receptor 2(HER2). Spectrin αII expression is an independent prognostic factor of overall survival and survival after recurrence in ovarian carcinoma. Spectrin αII expression is a useful predictor of anticancer drug resistance in ovarian carcinoma.

    2. You have full text access to this OnlineOpen article
      Dynamic changes of driver genes’ mutations across clinical stages in nine cancer types

      Xia Li

      Version of Record online: 19 MAR 2016 | DOI: 10.1002/cam4.704

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      We investigated 138 driver genes’ mutation changes across clinical stages using 3,477 cases in nine cancer types from the Cancer Genome Atlas (TCGA) and constructed their temporal order relationships. We categorized three patterns for the behaviors of driver genes’ mutation changes in the nine cancer types and observed different codon changes dominated in different stages, highlighting the critical role of the hotspot region for driver gene's tumorigenesis.

  12. Short Reports

    1. You have full text access to this OnlineOpen article
      Mammary tumor growth and metastasis are reduced in c-Kit mutant Sash mice

      Licai He, Zhenfeng Zhu, Shang Chen, Yongping Wang and Haihua Gu

      Version of Record online: 19 MAR 2016 | DOI: 10.1002/cam4.696

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      The function of mast cells in breast cancer is still unclear based on published studies. To clarify the role of mast cells in breast cancer, we examined the effects of loss of mast cells on tumor development and metastasis using the well-known transgenic mammary tumor and mast cell deficient mouse models. Our results support a positive role of mast cells in breast cancer by promoting tumor growth and metastasis.

  13. Original Research

    1. You have full text access to this OnlineOpen article
      Blood lipids and prostate cancer: a Mendelian randomization analysis

      Caroline J. Bull, Carolina Bonilla, Jeff M. P. Holly, Claire M. Perks, Neil Davies, Philip Haycock, Oriana Hoi Yun Yu, J. Brent Richards, Rosalind Eeles, Doug Easton, Zsofia Kote-Jarai, Ali Amin Al Olama, Sara Benlloch, Kenneth Muir, Graham G. Giles, Robert J. MacInnis, Fredrik Wiklund, Henrik Gronberg, Christopher A. Haiman, Johanna Schleutker, Børge G. Nordestgaard, Ruth C. Travis, David Neal, Nora Pashayan, Kay-Tee Khaw, Janet L. Stanford, William J. Blot, Stephen Thibodeau, Christiane Maier, Adam S. Kibel, Cezary Cybulski, Lisa Cannon-Albright, Hermann Brenner, Jong Park, Radka Kaneva, Jyotsna Batra, Manuel R. Teixeira, Agnieszka Micheal, Hardev Pandha, George Davey Smith, Sarah J. Lewis, Richard M. Martin and The PRACTICAL consortium

      Version of Record online: 19 MAR 2016 | DOI: 10.1002/cam4.695

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      Using a Mendelian randomization framework, we have found some evidence to suggest an association between low-density lipoprotein and triglycerides and more clinically severe PCa, but no evidence between high-density lipoprotein and these outcomes. There is an unmet clinical need to distinguish between indolent PCas and those that will progress to impact a man's life. Our findings indicate that blood lipids may be involved in this distinction.

    2. You have full text access to this OnlineOpen article
      A prognostic model for platinum-doublet as second-line chemotherapy in advanced non-small-cell lung cancer patients

      Hongnan Mo, Xuezhi Hao, Yutao Liu, Lin Wang, Xingsheng Hu, Jianping Xu, Sheng Yang, Puyuan Xing, Youwu Shi, Bo Jia, Yan Wang, Junling Li, Hongyu Wang, Ziping Wang, Yan Sun and Yuankai Shi

      Version of Record online: 19 MAR 2016 | DOI: 10.1002/cam4.689

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      This study proposed a prognostic nomogram and a score system for platinum sensitivity in advanced non-small-cell lung cancer (NSCLC), with a median survival of 16.0 months for patients received platinum rechallenge as second-line chemotherapy.

    3. You have full text access to this OnlineOpen article
      Multiplex determination of serological signatures in the sera of colorectal cancer patients using hydrogel biochips

      Veronika I. Butvilovskaya, Sofya B. Popletaeva, Vladimir R. Chechetkin, Zhanna I. Zubtsova, Marya V. Tsybulskaya, Larisa O. Samokhina, Leonid I. Vinnitskii, Aligeydar A. Ragimov, Elena I. Pozharitskaya, Galina A. Grigor´eva, Natalya Y. Meshalkina, Svetlana V. Golysheva, Nadezhda V. Shilova, Nicolai V. Bovin, Aleksander S. Zasedatelev and Alla Y. Rubina

      Version of Record online: 19 MAR 2016 | DOI: 10.1002/cam4.692

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      Successful treatment of colorectal cancer depends on its early diagnostics. Aberrant glycosylation of tumor proteins and lipids results in unique signatures of antibodies against modified molecules. We developed a microarray of hydrogel elements that detects and quantifies these antibodies in patients’ sera (glycochip). Together with the measurement of major antibodies and a panel of conventional tumor markers, the glycochip enables early minimally invasive diagnostics of colorectal cancer (CRC) with the sensitivity and specificity exceeding existing methods.

    4. You have full text access to this OnlineOpen article
      The value of breast MRI in high-risk patients with newly diagnosed breast cancer to exclude invasive disease in the contralateral prophylactic mastectomy: Is there a role to choose wisely patients for sentinel node biopsy?

      Vivianne Freitas, Pavel Crystal, Supriya R. Kulkarni, Sandeep Ghai, Karina Bukhanov, Jaime Escallon and Anabel M. Scaranelo

      Version of Record online: 18 MAR 2016 | DOI: 10.1002/cam4.663

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      The greatest strength of our study certainly is to confirm the highest MRI-negative predictive value for invasive cancers (IC) in this cohort that was of 100%. The clinical impact is relevant when obtained by a noninvasive preoperative method as the sentinel node biopsy (SLNB) is the standard procedure in patient with invasive disease.

    5. You have full text access to this OnlineOpen article
      Recombinant horseradish peroxidase variants for targeted cancer treatment

      Günther Bonifert, Lisa Folkes, Christoph Gmeiner, Gabi Dachs and Oliver Spadiut

      Version of Record online: 15 MAR 2016 | DOI: 10.1002/cam4.668

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      Recombinantly produced glyco-engineered horseradish peroxidase (HRP) C1A is an efficient tool for targeted cancer treatment. Our findings might pave the way for a revival of the powerful combination indole-3-acetic acid IAA/HRP in antibody directed enzyme prodrug therapy (ADEPT) and an increased use of the versatile isoenzyme HRP C1A in cancer research in the future.

    6. You have full text access to this OnlineOpen article
      Radiotherapy plus EGFR TKIs in non-small cell lung cancer patients with brain metastases: an update meta-analysis

      Tao Jiang, Weijie Min, Yanan Li, Zhijian Yue, Chunyan Wu and Caicun Zhou

      Version of Record online: 14 MAR 2016 | DOI: 10.1002/cam4.673

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      Radiotherapy plus epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKIs) produced superior risk ratio and disease control rate, and markedly prolonged the central nervous system (CNS)-TTP and overall survival of non-small cell lung cancer (NSCLC) patients with brain metastasis (BM). Meanwhile, combined group increased the incidence of overall adverse effects, especially rash and dry skin. In future, more high-quality and large-scale clinical trials are necessary to confirm the efficacy and safety of radiotherapy plus EGFR TKIs and select the most benefit population in NSCLC patients with BM.

    7. You have full text access to this OnlineOpen article
      The local treatment modalities in FIGO stage I-II small-cell carcinoma of the cervix are determined by disease stage and lymph node status

      Juan Zhou, Hong-Yi Yang, San-Gang Wu, Zhen-Yu He, Huan-Xin Lin, Jia-Yuan Sun, Qun Li and Zhan-Wen Guo

      Version of Record online: 14 MAR 2016 | DOI: 10.1002/cam4.687

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      Primary surgery is the most effective local treatment for Federation of Gynecology and Obstetrics (FIGO) stage I–II small-cell carcinoma of the cervix, as adjuvant radiotherapy or radical radiotherapy does not improve survival compared to radical surgery, especially in patients with FIGO stage I and lymph node negative disease.

    8. You have full text access to this OnlineOpen article
      Hypoxia-responsive miR-124 and miR-144 reduce hypoxia-induced autophagy and enhance radiosensitivity of prostate cancer cells via suppressing PIM1

      Hao Gu, Mingzhu Liu, Changmao Ding, Xin Wang, Rui Wang, Xinyu Wu and Ruitai Fan

      Version of Record online: 14 MAR 2016 | DOI: 10.1002/cam4.664

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      Hypoxia induced miR-124 and miR-144 downregulation may contribute to a prosurvival mechanism of prostate cancer cells to hypoxia and irradiation at least through attenuated suppressing of PIM1. This presents a potential therapeutic target for the treatment of prostate cancer.

    9. You have full text access to this OnlineOpen article
      Role of cancer stem cells in racial disparity in colorectal cancer

      Lulu Farhana, Fadi Antaki, Mohammad R. Anees, Pratima Nangia-Makker, Stephanie Judd, Timothy Hadden, Edi Levi, Farhan Murshed, Yingjie Yu, Eric Van Buren, Kulsoom Ahmed, Gregory Dyson and Adhip P. N. Majumdar

      Version of Record online: 14 MAR 2016 | DOI: 10.1002/cam4.690

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      Although the incidence of and mortality from colorectal cancer (CRC) is higher among the African Americans (AAs) than White people, the underlying biochemical mechanism(s) for this racial disparity are poorly understood. The present investigation is aimed at elucidating the regulatory mechanisms for differences in cancer stem/stem-like cells (CSCs) in colonic neoplasia between AAs and White people by evaluating the role of microRNAs, specifically the microRNA-1207-5p, which is shown to be upregulated in CRC. microRNA (miR)-1207-5p plays a critical role in regulating stemness in colon CSCs and suggests a potential molecular mechanism for the increased risk of CRC among AAs.

    10. You have full text access to this OnlineOpen article
      90-yttrium-ibritumomab tiuxetan consolidation of fludarabine, mitoxantrone, rituximab in intermediate/high-risk follicular lymphoma: updated long-term results after a median follow-up of 7 years

      Beatrice Casadei, Cinzia Pellegrini, Alessandro Pulsoni, Giorgia Annechini, Amalia De Renzo, Vittorio Stefoni, Alessandro Broccoli, Letizia Gandolfi, Federica Quirini, Lorenzo Tonialini, Alice Morigi, Lisa Argnani and Pier Luigi Zinzani

      Version of Record online: 14 MAR 2016 | DOI: 10.1002/cam4.684

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      Consolidation with radioimmunotherapy (RIT) after the induction phase including conventional chemoimmunotherapy became an attractive strategy for patients with advanced follicular lymphoma but updates of the long-term outcomes of this approach are lacking. For this reason, we report updated long-term efficacy and toxicity results of a sequential treatment with four cycles of fludarabine, mitoxantrone, and rituximab followed by 90Y-IT as a front-line therapy for untreated patients with intermediate/high-risk follicular lymphoma. These data represented the first evidence of a real role even in the long period of RIT after a fludarabine-containing regimen plus rituximab in the treatment of high-risk follicular lymphoma: a long-term of disease-free survival (63%) and a relevant patients' responsiveness to subsequent therapies.

    11. You have full text access to this OnlineOpen article
      Combined detection of serum Dickkopf-1 and its autoantibodies to diagnose esophageal squamous cell carcinoma

      Yu-Hui Peng, Yi-Wei Xu, Hong Guo, Li-Sheng Huang, Hua-Zhen Tan, Chao-Qun Hong, Shan-Shan Li, Li-Yan Xu and En-Min Li

      Version of Record online: 14 MAR 2016 | DOI: 10.1002/cam4.702

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      Detection of serum/plasma biomarker may benefit early diagnosis of esophageal squamous cell carcinoma (ESCC). We evaluate the diagnostic value of serum Dickkopf-1 (DKK-1) combined with DKK-1 autoantibodies in a training cohort and a validation cohort. Our findings offers evidence that combined detection of serum DKK1 and DKK1 autoantibodies has the power of discrimination between early ESCC patients and normal controls. Moreover, serum DKK-1 and DKK-1 autoantibody may be potential markers of therapeutic surveillance for ESCC.

  14. Short Reports

    1. You have full text access to this OnlineOpen article
      History of chickenpox in glioma risk: a report from the glioma international case–control study (GICC)

      E. Susan Amirian, Michael E. Scheurer, Renke Zhou, Margaret R. Wrensch, Georgina N. Armstrong, Daniel Lachance, Sara H. Olson, Ching C. Lau, Elizabeth B. Claus, Jill S. Barnholtz-Sloan, Dora Il'yasova, Joellen Schildkraut, Francis Ali-Osman, Siegal Sadetzki, Robert B. Jenkins, Jonine L. Bernstein, Ryan T. Merrell, Faith G. Davis, Rose Lai, Sanjay Shete, Christopher I. Amos, Beatrice S. Melin and Melissa L. Bondy

      Version of Record online: 13 MAR 2016 | DOI: 10.1002/cam4.682

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      Using one of the largest study populations available to date, our study confirms the previously reported inverse association between a positive history of chickenpox and glioma risk. Our results provide additional evidence that the observed protective effect of chickenpox against glioma is unlikely to be coincidental.

  15. Original Research

    1. You have full text access to this OnlineOpen article
      High expression of TRF2, SOX10, and CD10 in circulating tumor microemboli detected in metastatic melanoma patients. A potential impact for the assessment of disease aggressiveness

      Elodie Long, Marius Ilie, Coraline Bence, Catherine Butori, Eric Selva, Salomé Lalvée, Christelle Bonnetaud, Gilles Poissonnet, Jean-Philippe Lacour, Philippe Bahadoran, Patrick Brest, Eric Gilson, Robert Ballotti, Véronique Hofman and Paul Hofman

      Version of Record online: 6 MAR 2016 | DOI: 10.1002/cam4.661

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      We show that circulating tumor cells are frequently detected in blood of MMPs either isolated or as circulating tumor microemboli. The detection of circulating tumor microemboli (CTMs) is synonymous of a higher metastatic potential at baseline and after first line of treatment with Vemurafenib. Higher expression of TRF2, CD10, and SOX10 in CTMs correlated with worse prognosis in MMPs, whereas these molecules were only weakly or not expressed in isolated circulating tumor cells (CTCs).

    2. You have full text access to this OnlineOpen article
      Glasgow prognostic score is an independent marker for poor prognosis with all cases of epithelial ovarian cancer

      Chiaki Omichi, Keiichiro Nakamura, Junko Haraga, Hisashi Masuyama and Yuji Hiramatsu

      Version of Record online: 1 MAR 2016 | DOI: 10.1002/cam4.681

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      This study investigated whether inflammatory markers of the Glasgow prognostic score (GPS) predicted progression-free survival (PFS) and overall survival (OS) for patients with all cases of epithelial ovarian cancer (OC). GPS can serve as an indicator of poor prognosis in patients with all stages of OC cancer, including early-stage disease and regardless of histology.

    3. You have full text access to this OnlineOpen article
      Outcomes of unplanned sarcoma excision: impact of residual disease

      Chris Charoenlap, Jungo Imanishi, Takaaki Tanaka, John Slavin, Samuel Y. Ngan, Sarat Chander, Michelle Maree Dowsey, Chatar Goyal and Peter F.M. Choong

      Version of Record online: 1 MAR 2016 | DOI: 10.1002/cam4.615

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      Residual disease in unplanned excision of soft tissue sarcoma was a poor prognostic predictor for all oncological outcomes. Soft tissue sarcomas should be treated in specialized centers and unplanned excision should be avoided because of its detrimental effect especially when residual disease remains after unplanned excision.

    4. You have full text access to this OnlineOpen article
      Long-term risk of gastrointestinal cancers in persons with gastric or duodenal ulcers

      Kirstine K. Søgaard, Dóra K Farkas, Lars Pedersen, Jennifer L. Lund, Reimar W. Thomsen and Henrik T. Sørensen

      Version of Record online: 29 FEB 2016 | DOI: 10.1002/cam4.680

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      Patients with gastric ulcer and duodenal ulcer have an increased risk of all gastrointestinal cancers, compared with the general population. Site-specific absolute cancer risks were similarly low in both Peptic ulcer disease (PUD) cohorts, and the direction of the associations with both gastric and other GI cancers was consistent among patients with the two ulcer types.

    5. You have full text access to this OnlineOpen article
      EphA4-deleted microenvironment regulates cancer development and leukemoid reaction of the isografted 4T1 murine breast cancer via reduction of an IGF1 signal

      Xuefeng Jing, Takashi Sonoki, Masayasu Miyajima, Takahiro Sawada, Nanako Terada, Shigeki Takemura and Kazushige Sakaguchi

      Version of Record online: 29 FEB 2016 | DOI: 10.1002/cam4.670

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      Host EphA4 expression regulates cancer development mainly via EphA4-mediated IGF1 synthesis signal. Thus, targeting this signaling pathway may provide a potential therapeutic option for cancer treatment.

    6. You have full text access to this OnlineOpen article
      Laparoscopic surgery for patients with colorectal cancer produces better short-term outcomes with similar survival outcomes in elderly patients compared to open surgery

      Soo Yun Moon, Sohee Kim, Soo Young Lee, Eon Chul Han, Sung-Bum Kang, Seung-Yong Jeong, Kyu Joo Park, Jae Hwan Oh and On behalf of the SEoul COlorectal Group (SECOG)

      Version of Record online: 29 FEB 2016 | DOI: 10.1002/cam4.671

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      In this study, laparoscopic colorectal surgery in elderly patients achieved better results than open surgery in terms of bowel function recovery, length of hospital stay, and postoperative complications. Overall survival and recurrence-free survival following laparoscopic and open colorectal resections were similar in the elderly population. These findings indicate that laparoscopic colorectal surgery in elderly patients is safe and feasible, and should be considered as a treatment option.

    7. You have full text access to this OnlineOpen article
      Body mass index and survival after diagnosis of invasive breast cancer: a study based on the Japanese National Clinical Database—Breast Cancer Registry

      Masaaki Kawai, Ai Tomotaki, Hiroaki Miyata, Takayuki Iwamoto, Naoki Niikura, Keisei Anan, Naoki Hayashi, Kenjiro Aogi, Takanori Ishida, Hideji Masuoka, Kotaro Iijima, Shinobu Masuda, Koichiro Tsugawa, Takayuki Kinoshita, Seigo Nakamura and Yutaka Tokuda

      Version of Record online: 29 FEB 2016 | DOI: 10.1002/cam4.678

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      Few studies have reported the association between body mass index and outcome among Asian breast cancer patients. We analyzed data for 20,090 female invasive breast cancer patients who had been followed up for a median period of 6.7 years (119,873.4 person years) entered in the National Clinical Database–Breast Cancer Registry between 2004 and 2006. The timing of body mass index (BMI) measurement was not specified. Being obese or underweight is associated with a higher risk of death among female breast cancer patients in Japan.

    8. You have full text access to this OnlineOpen article
      MiR-24 enhances radiosensitivity in nasopharyngeal carcinoma by targeting SP1

      Min Kang, Jingjian Xiao, Jun Wang, Pingting Zhou, Tingting Wei, Tingting Zhao and Rensheng Wang

      Version of Record online: 29 FEB 2016 | DOI: 10.1002/cam4.660

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      This study aimed to investigate the effect of microRNA (miR)-24 on the radiosensitivity of NPC cells. The results of this study suggested that the identified miR-24/Sp1 pathway contributed to the elucidation of the mechanisms of radiosensitivity in human NPC and that it may represent a potential therapeutic target.

    9. You have full text access to this OnlineOpen article
      The prognostic significance of monoclonal immunoglobulin gene rearrangement in conjunction with histologic B-cell aggregates in the bone marrow of patients with diffuse large B-cell lymphoma

      Yoon Ah Cho, Woo Ick Yang, Jae-Woo Song, Yoo Hong Min and Sun Och Yoon

      Version of Record online: 29 FEB 2016 | DOI: 10.1002/cam4.679

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      Histologic B-cell aggregates were more associated with monoclonality than polyclonality. A combination of monoclonality and histologic B-cell aggregates within the bone marrow was highly associated with poor prognosis and could be used to determine high-risk DLBLC patients with greater sensitivity and specificity than conventional microscopic examination or immunoglobulin gene rearrangement study alone.

    10. You have full text access to this OnlineOpen article
      Association between baseline serum glucose, triglycerides and total cholesterol, and prostate cancer risk categories

      Rhonda Arthur, Henrik Møller, Hans Garmo, Lars Holmberg, Pår Stattin, Håkan Malmstrom, Mats Lambe, Niklas Hammar, Göran Walldius, David Robinson, Ingmar Jungner and Mieke Van Hemelrijck

      Version of Record online: 29 FEB 2016 | DOI: 10.1002/cam4.665

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      Our findings suggest that men with glucose in the diabetic range are more likely to have lower PSA levels, but higher grade or advanced PCa. Conversely, men with glucose in the prediabetic range and those with hypertriglyceridemia tended to have higher PSA levels as well as higher grade or more advanced PCa.

    11. You have full text access to this OnlineOpen article
      Recreational physical activity and ovarian cancer risk in African American women

      Sarah E. Abbott, Elisa V. Bandera, Bo Qin, Lauren C. Peres, Patricia G. Moorman, Jill Barnholtz-Sloan, Ann G. Schwartz, Ellen Funkhouser, Edward S. Peters, Michele L. Cote, Anthony J. Alberg, Paul Terry, Melissa Bondy, Lisa E. Paddock, Sydnee Crankshaw, Frances Wang, Fabian Camacho and Joellen M. Schildkraut

      Version of Record online: 29 FEB 2016 | DOI: 10.1002/cam4.677

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      This is the first study of recreational physical activity (RPA) and ovarian cancer in an exclusively African American population, who have a higher prevalence of obesity and poorer ovarian cancer survival compared with whites. We found that mild and strenuous intensity RPA may be associated with reduced ovarian cancer risk. Further, our data suggest that these associations may be more pronounced in obese women.

    12. You have full text access to this OnlineOpen article
      Risk of breast cancer after false-positive results in mammographic screening

      Marta Román, Xavier Castells, Solveig Hofvind and My von Euler-Chelpin

      Version of Record online: 25 FEB 2016 | DOI: 10.1002/cam4.646

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      In this joint analysis based on individual level data from the population-based screening programs in Copenhagen and Funen in Denmark, Norway, and Spain, we estimated that women with false-positive screening results had a twofold risk of a later screen detected breast cancer compared to women with negative screening results. The increased risk should be considered when exploring the possibilities of stratified screening strategies.

  16. OrIginal Research

    1. You have full text access to this OnlineOpen article
      Effects of Nrf2 silencing on oxidative stress-associated intestinal carcinogenesis in mice

      Yuh Yokoo, Aki Kijima, Yuji Ishii, Shinji Takasu, Takuma Tsuchiya and Takashi Umemura

      Version of Record online: 21 FEB 2016 | DOI: 10.1002/cam4.672

      Thumbnail image of graphical abstract

      Nrf2 deficiency increased susceptibility to oxidative stress-induced small intestinal carcinogenesis in mice, in which COX2 overexpression followed by cell-cycle progression was involved. Individuals having single-nucleotide polymorphisms in NRF2 may have a risk of colorectal cancer to some extent.

  17. Original Research

    1. You have full text access to this OnlineOpen article
      Suppression of prostate cancer progression by cancer cell stemness inhibitor napabucasin

      Yiming Zhang, Zhong Jin, Huimin Zhou, Xueting Ou, Yawen Xu, Hulin Li, Chunxiao Liu and Bingkun Li

      Version of Record online: 21 FEB 2016 | DOI: 10.1002/cam4.675

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      A novel cancer cell stemness inhibitor, napabucasin, suppressed advanced prostate cancer effectively via inhibition of prostate stemness-high cancer cells.

    2. You have full text access to this OnlineOpen article
      Human polyomaviruses and incidence of cutaneous squamous cell carcinoma in the New Hampshire skin cancer study

      Anala Gossai, Tim Waterboer, Anne G. Hoen, Shohreh F. Farzan, Heather H. Nelson, Angelika Michel, Martina Willhauck-Fleckenstein, Brock C. Christensen, Ann E. Perry, Michael Pawlita and Margaret R. Karagas

      Version of Record online: 21 FEB 2016 | DOI: 10.1002/cam4.674

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      It is currently unclear whether human polyomaviruses (PyV) play a role in the etiology of cutaneous squamous cell carcinoma (SCC). Our findings from a population-based case–control study conducted in the United States provide limited evidence that certain PyV types may be related to the occurrence of SCC of the skin in the general population.

    3. You have full text access to this OnlineOpen article
      Discussions about reproductive and sexual health among young adult survivors of cancer

      Ying Wang, Leo Chen, Jenny Y. Ruan and Winson Y. Cheung

      Version of Record online: 21 FEB 2016 | DOI: 10.1002/cam4.666

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      We reviewed medical records of young adult cancer survivors regarding reproductive and sexual health discussions with their physicians. Our study highlights that such conversations occur inadequately, even though this dialog is associated with a higher likelihood of fertility preservation strategies.

    4. You have full text access to this OnlineOpen article
      Comparison of outcome of patients with CLL who are referred or nonreferred to a specialized CLL clinic: a Canadian population-based study

      Sara Beiggi, Versha Banerji, Angela Deneka, Jane Griffith, Spencer B. Gibson and James B. Johnston

      Version of Record online: 18 FEB 2016 | DOI: 10.1002/cam4.559

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      Chronic lymphocytic leukemia and small lymphocytic lymphoma (CLL/SLL) patients in Manitoba are either referred to the CLL Clinic at CancerCare Manitoba or are followed by other hematologists and general practitioners. Patients seen in the CLL clinic have an improved overall survival (OS) compared to nonreferred patients and this appears to be primarily related to improved OS in the elderly.

    5. You have full text access to this OnlineOpen article
      Role of palliative radiotherapy in the management of mural cardiac metastases: who, when and how to treat? A case series of 10 patients

      Alireza Fotouhi Ghiam, Laura A. Dawson, Wael Abuzeid, Sarah Rauth, Raymond W. Jang, Eric Horlick and Andrea Bezjak

      Version of Record online: 16 FEB 2016 | DOI: 10.1002/cam4.619

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      The success of palliative radiotherapy in improving clinical symptoms and achieving good local control for mural cardiac metastases calls for further consideration of this modality either as a single modality or in combination with surgery and/or chemotherapy. Our experience shows that common palliative dose fractionation schemes (such as 8, 20, or 30 Gy in 1, 5, and 10 fractions, respectively) is safe and effective and should be considered early in the management of these patients.

    6. You have full text access to this OnlineOpen article
      Is there a progression-free survival benefit of first-line crizotinib versus standard chemotherapy and second-line crizotinib in ALK-positive advanced lung adenocarcinoma? A retrospective study of Chinese patients

      Shaohua Cui, Yizhuo Zhao, Lili Dong, Aiqin Gu, Liwen Xiong, Jialin Qian, Wei Zhang, Yanjie Niu, Feng Pan and Liyan Jiang

      Version of Record online: 16 FEB 2016 | DOI: 10.1002/cam4.659

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      There was a significant progression-free survival (PFS) benefit of first-line crizotinib versus first-line standard chemotherapy in Chinese patients with anaplastic lymphoma kinase (ALK)-positive lung adenocarcinoma. Additionally, crizotinib showed promising efficacy in patients who received it as second-line therapy after progressive disease (PD) had occurred on first-line chemotherapy.

  18. Reviews

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      The role of stem cells in the prevention and treatment of radiation-induced xerostomia in patients with head and neck cancer

      Daan Nevens and Sandra Nuyts

      Version of Record online: 16 FEB 2016 | DOI: 10.1002/cam4.609

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      This review discusses the current knowledge of salivary gland stem cells in radiation-induced xerostomia and their value in the prevention and treatment of radiation-induced xerostomia.

  19. Original Research

    1. You have full text access to this OnlineOpen article
      A novel approach to predict cetuximab-induced hypersensitivity reaction: detection of drug-specific IgE on basophils

      Takuya Iwamoto, Akiharu Okamoto, Hajime Ishinaga, Kasumi Shimizu, Alberto A. Gayle, Naoya Arai, Kazuhiko Takeuchi and Masahiro Okuda

      Version of Record online: 16 FEB 2016 | DOI: 10.1002/cam4.658

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      We indicated for the first time that a quantification of the interaction between cetuximab and IgE on basophils, the site responsible for IgE-mediated allergy, allows a more precise definition of the clinical presentation of allergic reaction due to cetuximab.

    2. You have full text access to this OnlineOpen article
      Glycosylation status of serum immunoglobulin G in patients with prostate diseases

      Saiko Kazuno, Jun-ichi, Furukawa, Yasuro Shinohara, Kimie Murayama, Makoto Fujime, Takashi Ueno and Tsutomu Fujimura

      Version of Record online: 16 FEB 2016 | DOI: 10.1002/cam4.662

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      We report that N-linked (N-acetylhexosamine)2(deoxyhexose)(mannose)3(N-acetylglucosamine)2 was significantly increased in the serum IgG heavy chains of patients with prostate cancer compared with that of either benign prostatic disease patients or healthy normal subjects, whereas (hexose)(N-acetylhexosamine)2(deoxyhexose)(mannose)3 (N-acetylglucosamine)2 was more abundant in the heavy chains of healthy subjects and benign prostatic disease patients. Thus, an absence of the terminal hexose of N-linked glycans has been closely connected to the progression of prostate cancer.

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