Primary cutaneous B-cell lymphoma other than marginal zone: clinicopathologic analysis of 161 cases: Comparison with current classification and definition of prognostic markers
Marco Lucioni, Emilio Berti, Luca Arcaini, Giorgio A. Croci, Aldo Maffi, Catherine Klersy, Gaia Goteri, Carlo Tomasini, Pietro Quaglino, Roberta Riboni, Mariarosa Arra, Elena Dallera, Vieri Grandi, Mauro Alaibac, Antonio Ramponi, Sara Rattotti, Maria Giuseppina Cabras, Silvia Franceschetti, Giulio Fraternali-Orcioni, Nicola Zerbinati, Francesco Onida, Stefano Ascani, Maria Teresa Fierro, Serena Rupoli, Marcello Gambacorta, Pier Luigi Zinzani, Nicola Pimpinelli, Marco Santucci and Marco Paulli
Version of Record online: 26 SEP 2016 | DOI: 10.1002/cam4.865
This article deals with a series of 161 cases of primary cutaneous, nonmarginal zone B-cell lymphoma (BCL), which we retrospectively reviewed. We were able to identify a subset of cases, which we classified as primary cutaneous diffuse large BCL, not otherwise specified, displaying intermediate features—both histologic and clinical—between primary cutaneous follicular and “leg type” lymphoma. We also highlighted the relevance of immunohistochemical characterization—particularly the definition of the histogenic profile and BCL2/MYC expression—as well as of detection of BCL2 translocation in identifying prognostic subsets.