Reproducibility of Her2/neu scoring in gastric cancer and assessment of the 10% cut-off rule
Hans-Michael Behrens, Viktoria S. Warneke, Christine Böger, Nele Garbrecht, Eva Jüttner, Wolfram Klapper, Micaela Mathiak, Ilske Oschlies, Ursula Rudolph, Christiane Stuhlmann-Laeisz, David Trick, Christoph Röcken and Peter Hufnagl
Article first published online: 16 DEC 2014 | DOI: 10.1002/cam4.365
We studied the reproducibility of Her2/neu scoring in gastric cancer and its effect on the application of Trastuzumab, especially when the ratio of stained tumor is around the cutoff limit of 10%. It was demonstrated that the stained tumor ratio cannot be reliably determined. Thus stained tumor ratios around 10% may lead to erratic decisions whether to apply a Trastuzumab therapy. Therefore we propose to reconsider the 10% cutoff limit.