IKZF1 deletion is associated with a poor outcome in pediatric B-cell precursor acute lymphoblastic leukemia in Japan
Daisuke Asai, Toshihiko Imamura, So-ichi Suenobu, Akiko Saito, Daiichiro Hasegawa, Takao Deguchi, Yoshiko Hashii, Kimikazu Matsumoto, Hirohide Kawasaki, Hiroki Hori, Akihiro Iguchi, Yoshiyuki Kosaka, Koji Kato, Keizo Horibe, Keiko Yumura-Yagi, Junichi Hara and Megumi Oda, The Japan Association of Childhood Leukemia Study (JACLS)
Article first published online: 9 MAY 2013 | DOI: 10.1002/cam4.87
We conducted genetic analyses of IKZF1 deletion, point mutation of JAK2 exon 16, 17, and 21, CRLF2 expression, the presence of P2RY8-CRLF2 fusion and F232C mutation in CRLF2 in 202 pediatric BCP-ALL patients newly diagnosed and registered in Japan Childhood Leukemia Study ALL02 protocol to find out if IKZF1 deletion had reduced event-free survival and overall survival. JAK2 mutations and P2RY8-CRLF2 fusion were rarely detected. IKZF1 deletion was identified as adverse prognostic factor even in pediatric BCP-ALL showing good response to PSL.