Cancer Medicine

Cover image for Vol. 3 Issue 3

Early View (Online Version of Record published before inclusion in an issue)

Edited By: Qingyi Wei, M.D., Ph.D.

Online ISSN: 2045-7634

VIEW

  1. 1 - 67
  1. Original Research

    1. You have full text access to this OnlineOpen article
      HPV-positive oropharyngeal squamous cell carcinoma is associated with TIMP3 and CADM1 promoter hypermethylation

      Pauline M. W. van Kempen, Liselotte van Bockel, Weibel W. Braunius, Cathy B. Moelans, Marina van Olst, Rick de Jong, Inge Stegeman, Paul J. van Diest, Wilko Grolman and Stefan M. Willems

      Article first published online: 25 JUL 2014 | DOI: 10.1002/cam4.313

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      HPV-positive and HPV-negative oropharynx squamous cell carcinoma show distinct biological and clinical features. Our study further underscores this diversity by illustrating that HPV-positive and HPV-negative oropharyngeal squamous cell carcinoma (OPSCCs) also differ epigenetically.

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      Outpatient treatment costs and their potential impact on cancer care

      Takahiro Isshiki

      Article first published online: 24 JUL 2014 | DOI: 10.1002/cam4.308

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      Address points of stomach (orange), liver (green) cancer patients, and the hospital (red).

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      Contribution of transcription factor, SP1, to the promotion of HB-EGF expression in defense mechanism against the treatment of irinotecan in ovarian clear cell carcinoma

      Kohei Miyata, Fusanori Yotsumoto, Sung Ouk Nam, Takashi Odawara, Sadao Manabe, Toyokazu Ishikawa, Hiroaki Itamochi, Junzo Kigawa, Shuji Takada, Hiroshi Asahara, Masahide Kuroki and Shingo Miyamoto

      Article first published online: 24 JUL 2014 | DOI: 10.1002/cam4.301

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      In this study, we screened for transcription factor(s) that promote HB-EGF expression. Our results indicated that induction of HB-EGF expression contributed to defense mechanism against treatment of SN38 through the transcriptional activity of SP1 in OCCC cells.

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      Recurring DNA copy number gain at chromosome 9p13 plays a role in the activation of multiple candidate oncogenes in progressing oral premalignant lesions

      Rebecca Towle, Ivy F. L. Tsui, Yuqi Zhu, Sara MacLellan, Catherine F. Poh and Cathie Garnis

      Article first published online: 24 JUL 2014 | DOI: 10.1002/cam4.307

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      We report a recurrent DNA copy number gain event at chromosome 9p13 that is detectable in the earliest stages of oral premalignancy and is associated with increased progression likelihood for early stage oral lesions (which currently have no clinically viable means of delineating this risk). We find evidence that this alteration event is a product of selection for the activation of multiple oncogenes in parallel, each of which we show to be capable of regulating oral cancer phenotypes.

    5. You have full text access to this OnlineOpen article
      Inhibition of epidermal growth factor signaling by the cardiac glycoside ouabain in medulloblastoma

      Daniel Wolle, Seung Joon Lee, Zhiqin Li, Alisa Litan, Sonali P. Barwe and Sigrid A. Langhans

      Article first published online: 23 JUL 2014 | DOI: 10.1002/cam4.314

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      Aberrant activation of EGFR signaling has been observed in a high percentage of cancers and often is associated with poor outcome but targeted therapy for EGFR/ErbB signaling has remained a challenge due to its complex nature. We now show that the cardiac glycoside ouabain, an inhibitor of Na,K-ATPase, inhibits EGF signaling in medulloblastoma cells and prevents EGF-induced cell migration, a prerequisite for an invasive phenotype in these tumors. Thus, Na,K-ATPase is an attractive target to develop novel therapeutic strategies for cancers with aberrant activation of EGFR signaling.

    6. You have full text access to this OnlineOpen article
      Serum biomarkers reflecting specific tumor tissue remodeling processes are valuable diagnostic tools for lung cancer

      Nicholas Willumsen, Cecilie L. Bager, Diana J. Leeming, Victoria Smith, Claus Christiansen, Morten A. Karsdal, David Dornan and Anne-Christine Bay-Jensen

      Article first published online: 18 JUL 2014 | DOI: 10.1002/cam4.303

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      Noninvasive biomarkers reflecting degradation of collagen type I and citrullinated vimentin are highly applicable in the lung cancer setting. In the future, these markers may aid in diagnosing and characterizing patients with lung cancer.

    7. You have full text access to this OnlineOpen article
      Impact of adverse events, treatment modifications, and dose intensity on survival among patients with advanced renal cell carcinoma treated with first-line sunitinib: a medical chart review across ten centers in five European countries

      Camillo Porta, Antonin Levy, Robert Hawkins, Daniel Castellano, Joaquim Bellmunt, Paul Nathan, Ray McDermott, John Wagstaff, Paul Donnellan, John McCaffrey, Francis Vekeman, Maureen P. Neary, Jose Diaz, Faisal Mehmud and Mei Sheng Duh

      Article first published online: 18 JUL 2014 | DOI: 10.1002/cam4.302

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      This study of a large cohort of patients with advanced renal cell carcinoma (RCC) treated with sunitinib in Europe found a significant relationship between adverse events and dose intensity. It also found significant correlations between dose intensity and shorter survival, and between dose discontinuation and shorter survival.

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      Roles of histamine on the expression of aldehyde dehydrogenase 1 in endometrioid adenocarcinoma cell line

      Yi Wang, Yang Jiang, Jun-ichiro Ikeda, Tian Tian, Atsushi Sato, Hiroshi Ohtsu and Eiichi Morii

      Article first published online: 10 JUL 2014 | DOI: 10.1002/cam4.296

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      Histamine increased aldehyde dehydrogenase 1 (ALDH1) high population in endometrioid adenocarcinoma via histamine H1 receptor. As ALDH1 activity is supposed to be a general cancer-initiating cell (CIC) marker, this finding may provide an adjuvant therapeutic approach to eradicate CICs.

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      Newly established ELISA for N-ERC/mesothelin improves diagnostic accuracy in patients with suspected pleural mesothelioma

      Tadashi Sato, Yohei Suzuki, Takanori Mori, Masahiro Maeda, Masaaki Abe, Okio Hino and Kazuhisa Takahashi

      Article first published online: 10 JUL 2014 | DOI: 10.1002/cam4.297

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      The current study was designed to improve our previous enzyme-linked immunosorbent assay (ELISA) system for measuring N-ERC/mesothelin and to demonstrate the clinical usefulness of the modified ELISA system in patients with suspected pleural mesothelioma. A newly established ELISA system improved the sensitivity and specificity for the diagnosis of pleural mesothelioma in the current cohort compared with our previous system. A new ELISA showed better reproducibility and displayed the tendency of both higher sensitivity and higher specificity in plasma than in serum.

    10. You have full text access to this OnlineOpen article
      Cardiovascular event-free survival after adjuvant radiation therapy in breast cancer patients stratified by cardiovascular risk

      Nneka C. Onwudiwe, Young Kwok, Eberechukwu Onukwugha, John D. Sorkin, Ilene H. Zuckerman, Fadia T. Shaya and C. Daniel Mullins

      Article first published online: 10 JUL 2014 | DOI: 10.1002/cam4.283

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      The objective of this study was to estimate the risk of a cardiovascular event or death associated with modern radiation in breast cancer patients with varying baseline cardiovascular risk. This study showed that elderly women with breast cancer who had preexisting cardiovascular disease and receiving radiation treatment are at a greater risk for the combined outcome in the first 6 months.

    11. You have full text access to this OnlineOpen article
      Volumetric PET/CT parameters predict local response of head and neck squamous cell carcinoma to chemoradiotherapy

      Atsushi Hanamoto, Mitsuaki Tatsumi, Yukinori Takenaka, Toshimitsu Hamasaki, Toshimichi Yasui, Susumu Nakahara, Yoshifumi Yamamoto, Yuji Seo, Fumiaki Isohashi, Kazuhiko Ogawa, Jun Hatazawa and Hidenori Inohara

      Article first published online: 9 JUL 2014 | DOI: 10.1002/cam4.295

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      It is not well established whether pretreatment 18F-FDG PET/CT can predict local response of head and neck squamous cell carcinoma to chemoradiotherapy. Predictive efficacy of pretreatment 18F-FDG PET/CT varies with different primary sites and chosen parameters. Local response of laryngohypopharyngeal cancer is highly predictable by volume-based PET/CT parameters.

    12. You have full text access to this OnlineOpen article
      New prognostic factors and scoring system for patients with skeletal metastasis

      Hirohisa Katagiri, Rieko Okada, Tatsuya Takagi, Mitsuru Takahashi, Hideki Murata, Hideyuki Harada, Tetsuo Nishimura, Hirofumi Asakura and Hirofumi Ogawa

      Article first published online: 9 JUL 2014 | DOI: 10.1002/cam4.292

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      The results of this study identified six significant prognostic factors, including laboratory data, for the patients with skeletal metastasis. With this updated scoring system, life expectancy may be predicted more accurately; thus, a more optimal treatment may be selected.

    13. You have full text access to this OnlineOpen article
      Fatigue in patients with advanced renal cell carcinoma receiving sunitinib on an intermittent versus continuous dosing schedule in a randomized phase II trial

      David Cella, Sally E. Jensen, Elizabeth A. Hahn, Jennifer L. Beaumont, Beata Korytowsky, Helen Bhattacharyya and Robert Motzer

      Article first published online: 9 JUL 2014 | DOI: 10.1002/cam4.286

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      In a randomized trial comparing the sunitinib 4-week on/2-week off schedule to a continuous daily dose schedule, the 4/2 arm was associated with a greater degree of variability in fatigue reflecting a possible “on-off” effect whereby patients receiving the 4/2 schedule reported less fatigue at the beginning of each cycle compared to Day 29. The findings can inform the care for individuals with advanced renal cell carcinoma receiving intermittent dosing of sunitinib.

    14. You have full text access to this OnlineOpen article
      Epidemiology and survivorship of soft tissue sarcomas in adults: a national cancer database report

      Robert M. Corey, Katrina Swett and William G. Ward

      Article first published online: 8 JUL 2014 | DOI: 10.1002/cam4.288

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      The data reported herein contains demographic and survivorship data on 34 distinct soft tissue sarcomas in 63,714 patients. These data are unprecedented in its scope and size and provides an accurate oversight picture of the number of such cases in the USA and the true overall associated survivorship for these entities over the years reported. These data should form a reference baseline for comparisons of future series.

    15. You have full text access to this OnlineOpen article
      Use of percutaneous image-guided coaxial core-needle biopsy for diagnosis of intraabdominal lymphoma

      Ikuo Shimizu, Yoichi Okazaki, Wataru Takeda, Takehiko Kirihara, Keijiro Sato, Yuko Fujikawa, Toshimitsu Ueki, Yuki Hiroshima, Masahiko Sumi, Mayumi Ueno, Naoaki Ichikawa and Hikaru Kobayashi

      Article first published online: 8 JUL 2014 | DOI: 10.1002/cam4.224

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      Percutaneous core-needle biopsy revealed highly effective for diagnosis of intraabdominal lymphomas in comparison to surgical biopsy. It also helps attain immunohistological distinction as well as more timely therapy initiation.

    16. You have full text access to this OnlineOpen article
      Primary squamous cell carcinomas in the thyroid gland: an individual participant data meta-analysis

      Jae Keun Cho, Seung-Hoon Woo, Junoh Park, Min-Ji Kim and Han-Sin Jeong

      Article first published online: 4 JUL 2014 | DOI: 10.1002/cam4.287

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      To better understand the clinical characteristics of primary thyroid squamous cell carcinomas and to identify the prognostic factors, we performed a systematic review and individual participant data meta-analysis. The survival of these patients was ~20% in 3 years, but complete resection of disease correlated with improved survival.

    17. You have full text access to this OnlineOpen article
      Combining the pan-aurora kinase inhibitor AMG 900 with histone deacetylase inhibitors enhances antitumor activity in prostate cancer

      Channing J. Paller, Michel D. Wissing, Janet Mendonca, Anup Sharma, Eugene Kim, Hea-Soo Kim, Madeleine S. Q. Kortenhorst, Stephanie Gerber, Marc Rosen, Faraz Shaikh, Marianna L. Zahurak, Michelle A. Rudek, Hans Hammers, Charles M. Rudin, Michael A. Carducci and Sushant K. Kachhap

      Article first published online: 2 JUL 2014 | DOI: 10.1002/cam4.289

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      Combination therapy consisting of AMG 900, a pan-aurora kinase inhibitor, with the histone deacetylase inhibitors (HDACIs) valproic acid (VPA), and vorinostat (SAHA) was tested in prostate cancer cells. In vitro, the combination had synergistic antitumor activity. In vivo studies indicated decreased tumor growth in mice treated with low-dose AMG 900 and vorinostat compared to either agent alone.

    18. You have full text access to this OnlineOpen article
      Intensity-modulated pelvic radiation therapy and simultaneous integrated boost to the prostate area in patients with high-risk prostate cancer: a preliminary report of disease control

      Biancamaria Saracino, Maria Grazia Petrongari, Simona Marzi, Vicente Bruzzaniti, Gomellini Sara, Stefano Arcangeli, Giorgio Arcangeli, Paola Pinnarò, Carolina Giordano, Anna Maria Ferraro and Lidia Strigari

      Article first published online: 28 JUN 2014 | DOI: 10.1002/cam4.278

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      The treatment of pelvic nodes for high-risk prostate cancer is still controversial. The benefit and safety of whole pelvic irradiation using pelvic intensity-modulated radiation therapy (IMRT) and simultaneous boost to the prostatic area in association with 2-year androgen deprivation therapy (ADT) was evaluated. It was found that simultaneous integrated boost (SIB) technique is a well-tolerated treatment. High disease control in patients with prostate cancer requiring lymph node treatment was achieved.

    19. You have full text access to this OnlineOpen article
      Osteoprotegerin expression in triple-negative breast cancer cells promotes metastasis

      Michael Weichhaus, Prabu Segaran, Ashleigh Renaud, Dirk Geerts and Linda Connelly

      Article first published online: 28 JUN 2014 | DOI: 10.1002/cam4.277

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      Breast tumor cells express the protein osteoprotegerin (OPG), but the functional consequences of this are not clear. Here, we show that OPG expression promotes metastasis in triple-negative breast cancer cells.

    20. You have full text access to this OnlineOpen article
      Cancer stem cells and cisplatin-resistant cells isolated from non-small-lung cancer cell lines constitute related cell populations

      Blanca D. Lopez-Ayllon, Veronica Moncho-Amor, Ander Abarrategi, Inmaculada Ibañez de Cáceres, Javier Castro-Carpeño, Cristobal Belda-Iniesta, Rosario Perona and Leandro Sastre

      Article first published online: 24 JUN 2014 | DOI: 10.1002/cam4.291

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      Cisplatin-resistant cells were isolated from H460 and A549 non-small-cell lung cancer cell lines after a single treatment with the drug, simulating patient-treatment protocols. Cancer stem cells were also isolated from these cell lines for comparison. Both cisplatin resistant and stem cells showed increased cisplatin resistance, tumorigenicity, angiogenic, and metastatic capacity. Their gene expression profiles were highly related. Furthermore, the presence of cells with Stem characteristics in patient's surgical samples was related to their sensitivity to cisplatin.

    21. You have full text access to this OnlineOpen article
      Early inflammatory response in epithelial ovarian tumor cyst fluids

      Björg Kristjánsdóttir, Karolina Partheen, Eric T. Fung, Christine Yip, Kristina Levan and Karin Sundfeldt

      Article first published online: 20 JUN 2014 | DOI: 10.1002/cam4.282

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      The majority of epithelial ovarian cancer consists of cysts, the cyst fluid is in direct contact or inside the pathology itself. Inflammation has a central role in all steps of cancer, and we hypothesized and confirmed that inflammatory response could be found in the closeness to the pathology before it presents in the peripheral circulation.

    22. You have full text access to this OnlineOpen article
      CT versus FDG-PET/CT response evaluation in patients with metastatic colorectal cancer treated with irinotecan and cetuximab

      Kristin Skougaard, Helle Hjorth Johannesen, Dorte Nielsen, Jakob Vasehus Schou, Benny Vittrup Jensen, Estrid V. S. Høgdall and Helle Westergren Hendel

      Article first published online: 18 JUN 2014 | DOI: 10.1002/cam4.271

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      Colorectal cancer patients treated with irinotecan and cetuximab were evaluated with both computed tomography (CT) and positron emission tomography (PET/CT). Morphologic and metabolic response agreement was poor. Response Evaluation Criteria in Solid Tumors and Positron Emission Tomography Response Criteria in Solid Tumors response distribution correlated differently with survival.

    23. You have full text access to this OnlineOpen article
      The effect of metformin on breast cancer outcomes in patients with type 2 diabetes

      Bridget A. Oppong, Lindsay A. Pharmer, Sabine Oskar, Anne Eaton, Michelle Stempel, Sujata Patil and Tari A. King

      Article first published online: 18 JUN 2014 | DOI: 10.1002/cam4.259

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      Here, we examine whether metformin use influences breast cancer (BC) outcomes in women with type 2 diabetes. We find that in our study cohort of patients with type 2 diabetes receiving systemic chemotherapy for invasive BC, the use of metformin was not associated with improved outcomes.

    24. You have full text access to this OnlineOpen article
      Statin use and its effect on all-cause mortality of melanoma patients: a population-based Dutch cohort study

      Elisabeth Livingstone, Loes M. Hollestein, Myrthe P. P. van Herk-Sukel, Lonneke van de Poll-Franse, Arjen Joosse, Bastian Schilling, Tamar Nijsten, Dirk Schadendorf and Esther de Vries

      Article first published online: 17 JUN 2014 | DOI: 10.1002/cam4.285

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      Statins have demonstrated anticancer effects on melanoma cell lines and in mouse models. In this population-based study, statin use either before or after melanoma diagnosis did not have a significant effect on survival of melanoma patients. Stratification on gender, however, showed a favorable outcome in male statin users compared to nonusers but was unchanged in females.

    25. You have full text access to this OnlineOpen article
      The natural history of intravascular lymphomatosis

      Ekokobe Fonkem, Edwin Lok, David Robison, Shiva Gautam and Eric T. Wong

      Article first published online: 14 JUN 2014 | DOI: 10.1002/cam4.269

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      Predictive factors for response to rituximab and doxorubicin. Three-dimensional plot of the MANOVA analysis showing a cut off of age at 71 years and LDH at 577 had the greatest influence on the time from treatment to death (two degrees of freedom, P = 0.0345).

    26. You have full text access to this OnlineOpen article
      Expression of two parental imprinted miRNAs improves the risk stratification of neuroblastoma patients

      Charles-Henry Gattolliat, Gwénaël Le Teuff, Valérie Combaret, Eugénie Mussard, Dominique Valteau-Couanet, Pierre Busson, Jean Bénard and Sétha Douc-Rasy

      Article first published online: 13 JUN 2014 | DOI: 10.1002/cam4.264

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      Neuroblastoma, the most common solid tumor of childhood, is characterized by the high variability of its clinical behavior ranging from spontaneous regression to rapid progression despite aggressive therapy. In this study, we found that the expression of two parental imprinted miRNAs, miR-487b and miR-516a-5p, predicts more accurately relapse and death with a greater performance. Expression of miR-487b and miR-516a-5p, biologically stable molecules, might be a surrogate prognostic marker able to improve stratification of neuroblastoma leading to a better treatment management.

    27. You have full text access to this OnlineOpen article
      Risk of squamous cell skin cancer after organ transplant associated with antibodies to cutaneous papillomaviruses, polyomaviruses, and TMC6/8 (EVER1/2) variants

      Margaret M. Madeleine, Joseph J. Carter, Lisa G. Johnson, Gregory C. Wipf, Connie Davis, Daniel Berg, Karen Nelson, Janet R. Daling, Stephen M. Schwartz and Denise A. Galloway

      Article first published online: 10 JUN 2014 | DOI: 10.1002/cam4.280

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      Squamous cell skin cancer (SCSC) disproportionately affects organ transplant recipients, and may be related to increased viral replication in the setting of immune suppression after transplant. This study suggests that HPV37, a betapapillomavirus, may play a role in the excess risk of SCSC among transplant recipients.

    28. You have full text access to this OnlineOpen article
      A phase II trial of BAY 43-9006 (sorafenib) (NSC-724772) in patients with relapsing and resistant multiple myeloma: SWOG S0434

      Gordan Srkalovic, Mohamad A. Hussein, Antje Hoering, Jeffrey A. Zonder, Leslie L. Popplewell, Harsha Trivedi, Sandy Mazzoni, Rachel Sexton, Robert Z. Orlowski and Bart Barlogie

      Article first published online: 10 JUN 2014 | DOI: 10.1002/cam4.276

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      Phase II SWOG trial of multityrosine kinase inhibitor, sorafenib, shown to have limited use as a single agent. Based on well-tolerated side effect profile and mechanism of action, future studies should focus on the addition of sorafenib with current therapies.

    29. You have full text access to this OnlineOpen article
      A three-protein biomarker panel assessed in diagnostic tissue predicts death from prostate cancer for men with localized disease

      Gianluca Severi, Liesel M. FitzGerald, David C. Muller, John Pedersen, Anthony Longano, Melissa C. Southey, John L. Hopper, Dallas R. English, Graham G. Giles and John Mills

      Article first published online: 7 JUN 2014 | DOI: 10.1002/cam4.281

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      We evaluated whether a panel of biomarkers (AZGP1, MUC1, NKX3.1, p53, and PTEN), assessed by immunohistochemistry on diagnostic tissue, could predict death from prostate cancer in men with localized disease. Expression of MUC1 and p53 was associated with increased mortality (MRR 2.51 and 3.08, P < 0.03), whereas AZGP1 expression was associated with decreased mortality (MRR 0.44, P = 0.04). For men with localized disease at diagnosis, assessing the expression of these three proteins in diagnostic tissue could potentially improve estimates of risk of dying from prostate cancer based only on Gleason score and clinical stage.

    30. You have full text access to this OnlineOpen article
      A randomized, phase II study of the anti-insulin-like growth factor receptor type 1 (IGF-1R) monoclonal antibody robatumumab (SCH 717454) in patients with advanced colorectal cancer

      Edward H. Lin, Heinz-Josef Lenz, Mansoor N. Saleh, Mary J. Mackenzie, James A. Knost, Kumudu Pathiraja, Ronald B. Langdon, Siu-Long Yao and Brian D. Lu

      Article first published online: 6 JUN 2014 | DOI: 10.1002/cam4.263

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      In this phase II study, patients with chemotherapy-refractory colorectal cancer were treated with the anti-insulin-like growth factor receptor type 1 (anti-IGF-1R) monoclonal antibody robatumumab. Few if any patients appeared to derive benefit from this treatment.

    31. You have full text access to this OnlineOpen article
      African American women's perceptions of cancer clinical trials

      Lindsey Haynes-Maslow, Paul Godley, Lisa Dimartino, Brandolyn White, Janice Odom, Alan Richmond and William Carpenter

      Article first published online: 6 JUN 2014 | DOI: 10.1002/cam4.284

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      Cancer clinical trials are important for resolving cancer health disparities for several reasons; however, clinical trials participation among African Americans is significantly lower than among Caucasians. This study engaged focus groups with African American cancer survivors or cancer caregivers. Trust in the health system and in one's physician was seen as important factors associated with patient willingness to enroll in clinical trials, and participants suggested that physicians who were compassionate and who engaged and educated their patients would build important trust requisite for patient participation in clinical trials.

    32. You have full text access to this OnlineOpen article
      A systematic review of microRNA expression profiling studies in human gastric cancer

      Sirjana Shrestha, Sheng-Da Hsu, Wei-Yun Huang, Hsi-Yuan Huang, WenLiang Chen, Shun-Long Weng and Hsien-Da Huang

      Article first published online: 5 JUN 2014 | DOI: 10.1002/cam4.246

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      Our study provides the systematic review of fourteen published microRNA expression profiling studies in gastric cancer. MiR-21 was reported consistently upregulated in 10 studies. MiR-375 was reported consistently downregulated in six studies. The group of consistently reported microRNAs in our study would provide information on microRNAs with potential role as the biomarkers in gastric cancer.

    33. You have full text access to this OnlineOpen article
      The impact of dietary isoflavonoids on malignant brain tumors

      Tina Sehm, Zheng Fan, Ruth Weiss, Marc Schwarz, Tobias Engelhorn, Nirjhar Hore, Arnd Doerfler, Michael Buchfelder, IIker Y. Eyüpoglu and Nic E. Savaskan

      Article first published online: 4 JUN 2014 | DOI: 10.1002/cam4.265

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      In this article, we uncovered that isoflavonoids as part of dietary fibers in nutrients are effective in primary brain tumors. Moreover, we identified that in particular biochanin A (BCA) is highly effective on glioma cells and importantly nontoxic for normal differentiated brain tissues. In ex vivo models (organotypic brain slice cultures) we found that BCA operates antiangiogenic and neuroprotective. Furthermore, we conducted in vivo experiments with magnetic resonance imaging scans demonstrating that administered BCA as a monotherapy was effective in reducing tumor-induced brain edema and prolonged survival although not significantly. These findings thus augment with BCA the range of a multimodal treatment approach.

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      Pharmacovigilance in practice: erythropoiesis-stimulating agents

      Michael Hedenus, Heinz Ludwig, David H. Henry and Eduard Gasal

      Article first published online: 3 JUN 2014 | DOI: 10.1002/cam4.275

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      Pharmacovigilance seeks to advance the safe use of marketed medical products by detecting and assessing potential safety issues and taking appropriate action to balance risks and benefits to patients. The pharmacovigilance process was employed to identify and minimize potential risks of erythropoiesis-stimulating agents (ESAs) used to treat anemia in patients with cancer receiving chemotherapy.

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      T-DM1, a novel antibody–drug conjugate, is highly effective against primary HER2 overexpressing uterine serous carcinoma in vitro and in vivo

      Diana P. English, Stefania Bellone, Carlton L. Schwab, Ileana Bortolomai, Elena Bonazzoli, Emiliano Cocco, Natalia Buza, Pei Hui, Salvatore Lopez, Elena Ratner, Dan-Arin Silasi, Masoud Azodi, Peter E. Schwartz, Thomas J. Rutherford and Alessandro D. Santin

      Article first published online: 2 JUN 2014 | DOI: 10.1002/cam4.274

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      Trastuzumab emtansine (T-DM1) shows significant antitumor effect in epidermal growth factor receptor-2 (HER2)-positive uterine serous carcinoma (USC) cell lines and USC xenografts. T-DM1 may represent a novel treatment option for HER2-positive USC patients harboring disease refractory to chemotherapy and/or unresponsive to trastuzumab.

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      High expression of L-type amino acid transporter 1 as a prognostic marker in bile duct adenocarcinomas

      Nobuyuki Yanagisawa, Kiyomi Hana, Norihiro Nakada, Masaaki Ichinoe, Wasaburo Koizumi, Hitoshi Endou, Isao Okayasu and Yoshiki Murakumo

      Article first published online: 2 JUN 2014 | DOI: 10.1002/cam4.272

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      In this study, we analyzed LAT1, LAT2, and CD98 expressions in a total of 134 bile duct adenocarcinomas including distal extrahepatic bile duct adenocarcinomas (EHCs), hilar cholangiocarcinomas (HCs), intrahepatic cholangiocarcinomas (ICCs), and ampullary adenocarcinomas (ACs). We found that LAT1 is useful as a significant prognostic marker in bile duct cancer as well as EHC. These results strongly suggest a potential target for future anticancer therapy with its inhibitors.

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      Development of a complete human anti-human transferrin receptor C antibody as a novel marker of oral dysplasia and oral cancer

      Kentaro Nagai, Shingo Nakahata, Shunsuke Shimosaki, Tomohiro Tamura, Yuudai Kondo, Takashi Baba, Tomohiko Taki, Masafumi Taniwaki, Gene Kurosawa, Yukio Sudo, Seiji Okada, Sumio Sakoda and Kazuhiro Morishita

      Article first published online: 2 JUN 2014 | DOI: 10.1002/cam4.267

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      Transferrin receptor C (TFRC) is a novel cell surface protein marker in oral dysplasia and oral squamous cell carcinoma (OSCC). A complete human anti-human TFRC antibody generated by phage-display method showed the therapeutic efficacy against OSCC cells in vitro and in vivo, suggesting that TFRC is an attractive molecular target in OSCC.

    38. You have full text access to this OnlineOpen article
      Let-7 microRNA-binding-site polymorphism in the 3′UTR of KRAS and colorectal cancer outcome: a systematic review and meta-analysis

      Scott M. Langevin and Brock C. Christensen

      Article first published online: 2 JUN 2014 | DOI: 10.1002/cam4.279

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      We conducted a meta-analysis of the prognostic significance of the LCS6 let-7-binding-site polymorphism in the 3′UTR of KRAS. We did not find any evidence of association with overall or disease-free survival, or by stage at diagnosis or treatment regimen.

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      Urokinase-type plasminogen activator receptor (uPAR) on tumor-associated macrophages is a marker of poor prognosis in colorectal cancer

      Martin Illemann, Ole Didrik Laerum, Jane Preuss Hasselby, Tine Thurison, Gunilla Høyer-Hansen, Hans Jørgen Nielsen, forthe Danish Study Group on Early Detection of Colorectal Cancer and Ib Jarle Christensen

      Article first published online: 30 MAY 2014 | DOI: 10.1002/cam4.242

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      This is the first demonstration that different molecular forms of uPAR are independent prognostic markers in CRC. In tumor-tissue samples, the number of uPAR-positive macrophages located in the tumor core is an independent prognostic marker. In blood from the same patients, the cleaved soluble uPAR-forms are independent prognostic markers. When uPAR(I) in blood and membrane-bound uPAR on macrophages in the tumor core are combined with stage, the prognostic precision increases more than tenfold, as compared to stage alone.

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      Fibroblastic growth factor receptor 1 amplification in osteosarcoma is associated with poor response to neo-adjuvant chemotherapy

      M. Fernanda Amary, Hongtao Ye, Fitim Berisha, Bhavisha Khatri, Georgina Forbes, Katie Lehovsky, Anna M. Frezza, Sam Behjati, Patrick Tarpey, Nischalan Pillay, Peter J. Campbell, Roberto Tirabosco, Nadège Presneau, Sandra J. Strauss and Adrienne M. Flanagan

      Article first published online: 27 MAY 2014 | DOI: 10.1002/cam4.268

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      In this study, we identify ~20% of patients whose osteosarcomas respond poorly to chemotherapy and exhibit FGFR1 gene amplification. This biomarker could be used to stratify patients for targeted therapies.

    41. You have full text access to this OnlineOpen article
      Tumor signatures of PTHLH overexpression, high serum calcium, and poor prognosis were observed exclusively in clear cell but not non clear cell renal carcinomas

      Masahiro Yao, Takayuki Murakami, Koichi Shioi, Nobuhiko Mizuno, Hiroki Ito, Keiichi Kondo, Hisashi Hasumi, Futoshi Sano, Kazuhide Makiyama, Noboru Nakaigawa, Takeshi Kishida, Yoji Nagashima, Shoji Yamanaka and Yoshinobu Kubota

      Article first published online: 26 MAY 2014 | DOI: 10.1002/cam4.270

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      We demonstrated that the previously characterized tumor signatures of high serum Ca due to high parathyroid hormone-like hormone expression and poor prognosis are clear cell renal carcinoma-specific features, whereas these characteristics are rare in non clear cell renal carcinomas.

    42. You have full text access to this OnlineOpen article
      Aberrant promoter methylation of PPP1R3C and EFHD1 in plasma of colorectal cancer patients

      Kiyoko Takane, Yutaka Midorikawa, Koichi Yagi, Ayako Sakai, Hiroyuki Aburatani, Tadatoshi Takayama and Atsushi Kaneda

      Article first published online: 23 MAY 2014 | DOI: 10.1002/cam4.273

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      Detection of methylation of PPP1R3C alone or in combination with EFHD1 in plasma DNA showed high sensitivity and specificity in colorectal cancer (CRC) patients. They may be useful biomarkers for CRC, especially for detection of early-stage CRCs.

    43. You have full text access to this OnlineOpen article
      FGFR3 expression in primary and metastatic urothelial carcinoma of the bladder

      Elizabeth A. Guancial, Lillian Werner, Joaquim Bellmunt, Aristotle Bamias, Toni K. Choueiri, Robert Ross, Fabio A. Schutz, Rachel S. Park, Robert J. O'Brien, Michelle S. Hirsch, Justine A. Barletta, David M. Berman, Rosina Lis, Massimo Loda, Edward C. Stack, Levi A. Garraway, Markus Riester, Franziska Michor, Philip W. Kantoff and Jonathan E. Rosenberg

      Article first published online: 20 MAY 2014 | DOI: 10.1002/cam4.262

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      Fibroblast growth factor receptor 3 (FGFR3) is frequently mutated or overexpressed in nonmuscle-invasive urothelial carcinoma (UC) where mutations are generally associated with lower rates of progression to invasive disease. In this report, we demonstrate that FGFR3 staining is present in nearly one third of muscle-invasive UC and half of metastases (albeit at low levels), but IHC detection of FGFR3 does not appear to impact overall survival. While the FGFR3 mutation rate is less than 10% in our population, mutant tumors had an increase in FGFR3 mRNA and a trend toward increased protein expression, similar to nonmuscle-invasive disease.

    44. You have full text access to this OnlineOpen article
      Cancer incidence in Khartoum, Sudan: first results from the Cancer Registry, 2009–2010

      Intisar E. Saeed, Hsin-Yi Weng, Kamal H. Mohamed and Sulma I. Mohammed

      Article first published online: 12 MAY 2014 | DOI: 10.1002/cam4.254

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      Cancer in Sudan and, in general, in the entire sub-Sahara Africa has long being ignored. Part of the problem is lack of data and research to document the need to implement the appropriate governmental policies to control cancer in that region. This manuscript reports on first data from the newly established National Cancer Registry at Khartoum, Sudan.

    45. You have full text access to this OnlineOpen article
      Identification and expression of troponin T, a new marker on the surface of cultured tumor endothelial cells by aptamer ligand

      Mst. Naznin Ara, Mamoru Hyodo, Noritaka Ohga, Kosuke Akiyama, Kyoko Hida, Yasuhiro Hida, Nobuo Shinohara and Hideyoshi Harashima

      Article first published online: 9 MAY 2014 | DOI: 10.1002/cam4.260

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      Aptamer AraHH001 targeted molecular target purification based on affinity purification and proteomic approach. Troponin T, as a AraHH001 target reporting here for the first time and expressed on the surface of tumor endothelial cells. Its presence was confirmed by measuring mRNA, protein levels, western blot, and a gel shift assay of AraHH001 with troponin.

    46. You have full text access to this OnlineOpen article
      The role of laser interstitial thermal therapy in enhancing progression-free survival of difficult-to-access high-grade gliomas: a multicenter study

      Alireza M. Mohammadi, Ammar H. Hawasli, Analiz Rodriguez, Jason L. Schroeder, Adrian W. Laxton, Paul Elson, Stephen B. Tatter, Gene H. Barnett and Eric C. Leuthardt

      Article first published online: 9 MAY 2014 | DOI: 10.1002/cam4.266

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      Laser ablation of brain tumors is a novel treatment modality which can replace surgical resection, especially in difficult to access tumor. This is the first outcome study of laser ablation in glioma patients.

  2. Reviews

    1. You have full text access to this OnlineOpen article
      Biosimilars 101: considerations for U.S. oncologists in clinical practice

      Luis H. Camacho, Craig P. Frost, Esteban Abella, Phuong K. Morrow and Sadie Whittaker

      Article first published online: 8 MAY 2014 | DOI: 10.1002/cam4.258

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      Biosimilars will be available in the United States soon and may provide alternative choices of biologic treatments for patients with cancer. This article reviews key issues for oncologists to consider to make informed decisions about incorporating biosimilars into their clinical practice.

  3. Original Research

    1. You have full text access to this OnlineOpen article
      U-251 revisited: genetic drift and phenotypic consequences of long-term cultures of glioblastoma cells

      Anja Torsvik, Daniel Stieber, Per Øyvind Enger, Anna Golebiewska, Anders Molven, Agnete Svendsen, Bengt Westermark, Simone P. Niclou, Thale Kristin Olsen, Martha Chekenya Enger and Rolf Bjerkvig

      Article first published online: 8 MAY 2014 | DOI: 10.1002/cam4.219

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      The presented work represents a thorough characterization of the commonly used U-251 cell line and its derivatives from its initiation in the 1960 ties. Since this cell line has been extensively misidentified in numerous prior publications, the presented work represents an important reference for the scientific community.

    2. You have full text access to this OnlineOpen article
      High CD49f expression is associated with osteosarcoma tumor progression: a study using patient-derived primary cell cultures

      Patrice Penfornis, David Z. Cai, Michael R. Harris, Ryan Walker, David Licini, Joseph D. A. Fernandes, Griffin Orr, Tejaswi Koganti, Chindo Hicks, Spandana Induru, Mark S. Meyer, Rama Khokha, Jennifer Barr and Radhika R. Pochampally

      Article first published online: 7 MAY 2014 | DOI: 10.1002/cam4.249

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      In this report we demonstrate that CD49 high expression in osteosarcoma (OS) is correlated with aggressive tumor progression. Furthermore, we describe isolation and characterization of four cell lines from primary OS tumors.

    3. You have full text access to this OnlineOpen article
      Predicting pneumonia mortality using CURB-65, PSI, and patient characteristics in patients presenting to the emergency department of a comprehensive cancer center

      Carmen Gonzalez, Tami Johnson, Kenneth Rolston, Kelly Merriman, Carla Warneke and Scott Evans

      Article first published online: 7 MAY 2014 | DOI: 10.1002/cam4.240

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      The performances of the CURB-65 and pneumonia severity index as tools for predicting pneumonia-related mortality in cancer patients are inadequate. Pneumonia patients who have undergone recent radiation therapy or stem cell transplant are at increased risk of mortality.

    4. You have full text access to this OnlineOpen article
      Late toxicity and quality of life after definitive treatment of prostate cancer: redefining optimal rectal sparing constraints for intensity-modulated radiation therapy

      Sravana K. Chennupati, Charles A. Pelizzari, Rangesh Kunnavakkam and Stanley L. Liauw

      Article first published online: 6 MAY 2014 | DOI: 10.1002/cam4.261

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      This is a modern-era (IMRT/IGRT), prospective collection of physician-assigned grade of toxicity, and patient-reported quality of life (EPIC) for several hundred patients. A detailed DVH analysis is performed, which suggests that there is a benefit toward optimizing rectal sparing to V70 Gy <10%. This is a dose sparing limit which is often readily achievable with current technology, but perhaps not as widely used in comparison to the more traditional V70 Gy <20%.

    5. You have full text access to this OnlineOpen article
      Steroid treatment increases the recurrence of radiation-induced organizing pneumonia after breast-conserving therapy

      Keisuke Otani, Kinji Nishiyama, Yuri Ito, Yoshifumi Kawaguchi and Hideo Inaji

      Article first published online: 3 MAY 2014 | DOI: 10.1002/cam4.255

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      The use of corticosteroids for the treatment of radiation-induced organizing pneumonia (RIOP) is controversial because it is associated with frequent relapses. Patient management without steroids substantially decreases relapses and the total duration of RIOP without the development of persistent pulmonary complications.

    6. You have full text access to this OnlineOpen article
      Role of latent membrane protein 1 in chronic active Epstein–Barr virus infection-derived T/NK-cell proliferation

      Takuto Ito, Hidetaka Kawazu, Takayuki Murata, Seiko Iwata, Saki Arakawa, Yoshitaka Sato, Kiyotaka Kuzushima, Fumi Goshima and Hiroshi Kimura

      Article first published online: 3 MAY 2014 | DOI: 10.1002/cam4.256

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      We here found that Epstein–Barr virus (EBV) latent membrane protein 1 plays a role in growth promotion of chronic active EBV infection (CAEBV), a lymphoproliferative disease associated with poor prognosis. Such analysis contributes to understanding of oncogenesis and may provide basic information for development of anti-cancer drug to EBV-positive proliferative diseases and cancers.

    7. You have full text access to this OnlineOpen article
      PAX1/SOX1 DNA methylation and cervical neoplasia detection: a Taiwanese Gynecologic Oncology Group (TGOG) study

      Hung-Cheng Lai, Yu-Che Ou, Tze-Chien Chen, Huei-Jean Huang, Ya-Min Cheng, Chi-Hau Chen, Tang-Yuan Chu, Shih-Tien Hsu, Cheng-Bin Liu, Yao-Ching Hung, Kuo-Chang Wen, Mu-Hsien Yu and Kung-Liahng Wang

      Article first published online: 3 MAY 2014 | DOI: 10.1002/cam4.253

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      A promising DNA methylation testing for cervical cancer detection is validated in a multicenter study. PAX1/SOX1 methylation corroborates Pap smear, providing superior accuracy for CIN3+ detection. Molecular DNA methylation testing may revolutionize cervical cancer screening in the future.

    8. You have full text access to this OnlineOpen article
      Complete response after autologous stem cell transplant in multiple myeloma

      Lalit Kumar, Nida Iqbal, Anjali Mookerjee, Rakesh Kumar Verma, Om D. Sharma, Atul Batra, Raja Pramanik and Ritu Gupta

      Article first published online: 29 APR 2014 | DOI: 10.1002/cam4.257

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      Achievement of complete response following autologous stem cell transplant for multiple myeloma is associated with longer overall and progression-free survival. Among complete responders, those who receive one to two lines of induction therapy pretransplant have superior progression-free and overall survival.

  4. Letters to the Editor

    1. You have full text access to this OnlineOpen article
      Regarding human cytomegalovirus in neuroblastoma

      Ola Forslund, Linda Holmquist Mengelbier and David Gisselsson

      Article first published online: 16 APR 2014 | DOI: 10.1002/cam4.243

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      Wolmer-Solberg et al., reported that six human neuroblastoma cell lines and the vast majority of clinical neuroblastoma samples contained HCMV DNA and expressed HCMV proteins. We could not replicate the data and therefore remain skeptical towards the prevalence of HCMV DNA in neuroblastomas.

  5. Original Research

    1. You have full text access to this OnlineOpen article
      Outcomes after 90Yttrium-ibritumomab tiuxetan-BEAM in diffuse large B-cell lymphoma: a meta-analysis

      Sophie Auger-Quittet, Yohan Duny, Jean-Pierre Daures and Philipe Quittet

      Article first published online: 16 APR 2014 | DOI: 10.1002/cam4.247

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      Diffuse large B-cell lymphoma (DLBCL) in relapse or refractory kept a poor prognosis despite autologous transplantation. In order to evaluate the clinical effects of Zevalin® in combination with BEAM followed by autologous transplantation in DLBCL, we conducted, to our knowledge, the first literature review and meta-analysis. Twelve studies (409 patients) were included. The 2-year OS and PFS were 85.5% and 67.7%, respectively. These results further emphasize the increase efficacy observed with the Z-BEAM regimen by Shimoni in 2012.

    2. You have full text access to this OnlineOpen article
      Environmental scan of anal cancer screening practices: worldwide survey results

      Jigisha Patel, Irving E. Salit, Michael J. Berry, Alexandra de Pokomandy, Mayura Nathan, Fred Fishman, Joel Palefsky and Jill Tinmouth

      Article first published online: 16 APR 2014 | DOI: 10.1002/cam4.250

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      Rates of anal cancer are increasing, particularly in high-risk populations; however, there is no universal consensus on optimal strategies for anal cancer screening, treatment, and follow-up. This survey is the first step toward understanding anal cancer screening practices around the world.

    3. You have full text access to this OnlineOpen article
      Investigation of cyanine dyes for in vivo optical imaging of altered mitochondrial membrane potential in tumors

      Satoru Onoe, Takashi Temma, Yoichi Shimizu, Masahiro Ono and Hideo Saji

      Article first published online: 16 APR 2014 | DOI: 10.1002/cam4.252

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      Through compound screening, we developed a novel cyanine dye (IC7-1-Bu) which enabled in vivo imaging of tumor mitochondrial hyperpolarization. We found that the length of the dye alkyl side chains greatly affected biodistribution as well as membrane potential sensitivity. This is the first report of a NIR dye that successfully images tumor mitochondrial hyperpolarization in vivo.

    4. You have full text access to this OnlineOpen article
      Intestinal tumor suppression in ApcMin/+ mice by prostaglandin D2 receptor PTGDR

      Brigette L. Tippin, Alan M. Kwong, Michael J. Inadomi, Oliver J. Lee, Jae Man Park, Alicia M. Materi, Virgilio S. Buslon, Amy M. Lin, Lili C. Kudo, Stanislav L. Karsten, Samuel W. French, Shuh Narumiya, Yoshihiro Urade, Eduardo Salido and Henry J. Lin

      Article first published online: 11 APR 2014 | DOI: 10.1002/cam4.251

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      Earlier we discovered that high prostaglandin D2 (PGD2) production inhibits bowel tumors, and here we identify receptor PTGDR as a mediator. PTGDR knockouts raised tumor counts in ApcMin/+ mice 30–40%. More tumors with PTGDR knockouts support a role for PGD2/PTGDR pathways in tumor inhibition—which may have an impact for chemoprevention approaches.

    5. You have full text access to this OnlineOpen article
      Does a parental history of cancer moderate the associations between impaired health status in parents and psychosocial problems in teenagers: a HUNT study

      Elisabeth Jeppesen, Ingvar Bjelland, Sophie D. Fosså, Jon H. Loge, Øystein Sørebø and Alv A. Dahl

      Article first published online: 10 APR 2014 | DOI: 10.1002/cam4.245

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      This study confirmed strong associations between impaired parental health and psychosocial problems in their teenagers. Our hypothesis that a history of parental cancer had small effects on these associations was supported. Such a history weakened several of the significant associations between parental impaired health variables and psychosocial problems in their teenagers.

    6. You have full text access to this OnlineOpen article
      AFAP1L1, a novel associating partner with vinculin, modulates cellular morphology and motility, and promotes the progression of colorectal cancers

      Ryo Takahashi, Satoshi Nagayama, Moritoshi Furu, Yoichiro Kajita, YongHui Jin, Tomohisa Kato, Seiya Imoto, Yoshiharu Sakai and Junya Toguchida

      Article first published online: 10 APR 2014 | DOI: 10.1002/cam4.237

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      AFAP1L1 (actin filament-associated protein 1-like 1) modulates cell shape and motility and inhibits anoikis of colorectal cancer cells by associating with vinculin, and will be a predictive biomarker for rectal cancer recurrences.

    7. You have full text access to this OnlineOpen article
      Prognostic significance of specific anti-WT1 IgG antibody level in plasma in patients with ovarian carcinoma

      Charlotta Andersson, Yusuke Oji, Nina Ohlson, Sihan Wang, Xingru Li, Ulrika Ottander, Eva Lundin, Haruo Sugiyama and Aihong Li

      Article first published online: 8 APR 2014 | DOI: 10.1002/cam4.244

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      We found that WT1 IgG antibody levels in plasma and high-WT1 expression in tissue specimens were associated with poor outcome in the subgroup of ovarian carcinoma (OC) patients. The results indicate that WT1 antibody measurements and WT1 protein staining could be useful as biomarkers for patient outcome in the subtypes of OC for individualized therapy postoperation and support the hypothesis that subtypes of OCs differ considerably in characteristics.

  6. Commentary

    1. You have full text access to this OnlineOpen article
      The scientific method: pillar and pitfall of cancer research

      Shi-Ming Tu, Mehmet Asim Bilen and Nizar M. Tannir

      Article first published online: 8 APR 2014 | DOI: 10.1002/cam4.248

  7. Reviews

    1. You have full text access to this OnlineOpen article
      Complement anaphylatoxins as immune regulators in cancer

      Eli T. Sayegh, Orin Bloch and Andrew T. Parsa

      Article first published online: 8 APR 2014 | DOI: 10.1002/cam4.241

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      Despite the longstanding concept of complement as a beneficial host immune defense, recent research has implicated the complement anaphylatoxins as propagators of tumor growth and progression. A systematic review of the literature identified six studies in experimental cancer models, which collectively suggest that complement regulates the composition and functional phenotype of tumor-infiltrating immune cells.

    2. You have full text access to this OnlineOpen article
      A role for G-CSF and GM-CSF in nonmyeloid cancers

      Alexander M. Aliper, Victoria P. Frieden-Korovkina, Anton Buzdin, Sergey A. Roumiantsev and Alex Zhavoronkov

      Article first published online: 1 APR 2014 | DOI: 10.1002/cam4.239

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      The Granulocyte colony-stimulating factor (G-CSF) or granulocyte-macrophage colony-stimulating factor (GM-CSF)-secreting cancers albeit not very common are, however, among the most rapidly advancing ones due to a cytokine-mediated immune suppression and tumor angiogenesis. Rapid diagnostic tools to differentiate G-CSF- or GM-CSF-secreting cancers are not well developed thus complicating individualized treatment choices for these patients. We analyzed the role of G-CSF and GM-CSF in the cytokine-secreting tumors of brain, lung, bladder, colon, skin, and prostate and provided insights into molecular components of the cytokine/receptor signaling. Given the increasing use of G-/GM-CSF-based vaccines and the recombinant cytokines in adjuvant treatments, there is a possibility of adverse effects and accelerating of the tumor growth in cancers addicted to the G-/GM-CSF-activated signaling.

  8. Original Research

    1. You have full text access to this OnlineOpen article
      A retrospective analysis of the effect of intraoperative opioid dose on cancer recurrence after non-small cell lung cancer resection

      Juan P. Cata, Visesh Keerty, Dinesh Keerty, Lei Feng, Peter H. Norman, Vijaya Gottumukkala, John R. Mehran and Mitchel Engle

      Article first published online: 1 APR 2014 | DOI: 10.1002/cam4.236

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      The use of opioid has been linked to immune suppression and animal studies suggest their association with tumor growth. In the present study, we demonstrated a possible association between cancer recurrence and intraoperative opioid use in stage I non-small cell lung cancer but not in stages II and III.

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