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Clinical Liver Disease

Cover image for Vol. 5 Issue 4

Edited By: Michael Lucey, MD

Online ISSN: 2046-2484

Associated Title(s): Hepatology, Liver Transplantation

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NEW ISSUE: Liver and the Microbiome

Guest Edited by Eamonn M.M. Quigley, M.D., F.R.C.P., F.A.C.P., F.A.C.G., F.R.C.P.I.

Microbiome-Immune Interactions and Liver Disease
James H. Tabibian M.D., Ph.D., Cyril Varghese M.D., Steven P. O’Hara Ph.D., and Nicholas F. LaRusso M.D.
Gut microbiome in liver disease
The human intestine represents a complex ecosystem, influenced by numerous factors including host genotype, diet, age, health status, and exposure to antibiotics. Learn about the microbiome and its potential impact on the initiation, progression, and complications of chronic liver disease.
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The Gut Microbiome: What Do We Know?
Francisco Guarner, M.D., Ph.D.
Review the composition, structure, and functions of the microbiome.
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The Metabolic Role of the Microbiota
Wiley Barton B.Sc. Fergus Shanahan M.D., Paul D. Cotter Ph.D., Orla O’Sullivan Ph.D.
Now methods of analysis have opened up our understanding of the microbime, as well as strategies to address disorders related to microbiome dysfunction.
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Is the Gut Microbiota Disturbed in Chronic Liver Disease?
Eamonn M.M. Quigley, M.D., F.R.C.P., F.A.C.P., F.A.C.G., F.R.C.P.I.
Due its location and role, the liver interacts with the microbiome in myriad ways, and disturbances within either can have important health effects.
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Microbiome and Complications of Liver Disease
Jasmohan S. Bajaj, M.D., M.S., F.A.C.G., A.G.A.F.
Microbiota cam influence the development of hepatic fibrosis through dysbiosis, a microbial imbalance that can negatively impact the host. Most cirrhosis treatments focus on changing the microbial landscape, but important questions remain.
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NEW in Liver Transplantation:

Care of the Patient With Cirrhosis
Anitha Yadav, M.D., and Hugo E. Vargas, M.D.
Caring for patients with cirrhosis involves multidisciplinary and timely management of several complications while patients are awaiting LT.
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Update on MELD and Organ Allocation
Eric F. Martin, M.D., and Christopher O’Brien, M.D., A.G.A.F., F.R.C.M.I.
Review the strengths, weaknesses, and recent changes in the MELD score as a tool for evaluation for LT.
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Check out what's new in CLD's sister journal, HEPATOLOGY

HEPATOLOGY Highlights




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Series on New Treatments for Hepatitis C

Guest Edited by Donald M. Jensen, M.D., F.A.C.P.

New Therapies for Hepatitis C: Latin American Perspectives
Rafael Claudino Botero, M.D., F.A.C.P., and Martin Tagle, M.D.
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Learn about the unique challenges for treating Hepatitis C in Latin America, including a detailed country by country analysis.
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Prefer to learn in Spanish? Read the article or watch an interview with Dr. Botero, todo en español!

Los Nuevos Tratamiento de Hepatitis C: Perspectivas Latinoamericanas
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Access to New Direct-Acting Antiviral Agents Against HCV Infection: A View From Spain
Santiago Tome, M.D., Esteban Otero, M.D.
The high cost of treatment, assumptions about the need for specialized management, and patient fear all combine to make treating HCV in Spain an ongoing healthcare problem.
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Prefer to learn in Spanish? Read the article or watch an interview with Dr. Tome, todo en español!

Accesibilidad a los nuevos agentes antivirales directoscontra la infeccion por VHC. Un punto de vista desde España
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New Treatments for HCV: Perspective From Asia
Ming-Lung Yu, M.D., Ph.D., and Wan-Long Chuang, M.D., Ph.D.
More than 80% of Asian persons infected with HCV have a favorable host genotype associated with a higher rate of sustained virological response to treatment with pegylated interferon and ribavirin. What does that mean for treatment?
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Treating HCV Infection in Children
Christine K. Lee, M.D., Maureen M. Jonas, M.D.
Perinatal transmission is the most common mode of hepatitis C virus (HCV) acquisition in children - read, watch, or listen to learn more.
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Series on Liver Surgery

Guest Edited by David Reich, M.D.

NEW in Liver Surgery:

Laparoscopic distal pancreatectomy
Rizwan Ahmed M.D., Christi M. Walsh M.S.N., C.R.N.P., and Martin A. Makary M.D., M.P.H.
Laparoscopic distal pancreatectomy
Know the indications, recent advances in and proper application of technique, and the patient outcomes for laparoscopic distal pancreatectomy.
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Pylorus preserving pancreaticoduodenectomy
Jacqueline M. Garonzik-Wang, M. B. Majella Doyle
PD has become the standard of care for resectable pancreatic cancer and premalignant lesions in the periampullary region. Learn about the technique from experts, including key surgical maneuvers.
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MORE from Liver Surgery:

Liver Resection After Thermal Ablation of Parenchymal Transection Margin Using Microwave Energy
David J. Reich, M.D., F.A.C.S.
Learn how applying a zone of thermally induced necrosis at the resection margin before transection can reduce blood loss and other adverse effects.
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Laparoscopic Liver Resection
David A. Geller M.D., Mohammad Khreiss M.D.
Learn why laparoscopic liver resection is rapidly being adopted for certain benign and malignant tumors, with more than 6000 cases now performed worldwide.
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Single-Incision Laparoscopic Cholecystectomy
Figure 4
Andres Castellanos, M.D., Jessica Fazendin, M.D., and Lucian Panait, M.D.
Experts explain what clinicians need to know about the indications, technical aspects, complications, and outcomes of single-incision laparoscopic cholecystectomy.
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