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Clinical Liver Disease

Cover image for Vol. 6 Issue 1

Edited By: Michael Lucey, MD

Online ISSN: 2046-2484

Associated Title(s): Hepatology, Liver Transplantation

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  • Current Issue:July 2015

    Volume 6, Issue 1

    Special Issue: The Future in Liver Medicine & Pall...

  • June 2015

    Volume 5, Issue 6

    Special Issue: The Future in Liver Medicine, Liver...

  • May 2015

    Volume 5, Issue 5

    Special Issue: Hepatic Encephalopathy & Liver Tran...

  • April 2015

    Volume 5, Issue 4

    Special Issue: Liver and the Microbiome & Liver Tr...

  • March 2015

    Volume 5, Issue 3

    Special Issue: Hepatic Encephalopathy & Liver in A...

Palliative Care

Guest Edited by Anne Larson, M.D. F.A.C.P. A.G.A.F.

Overall Health-Related Quality of Life in Patients With End-Stage Liver Disease
Zobair Younossi, M.D., M.P.H., and Linda Henry Ph.D.
HRQOL is a multidimensional concept that includes self-reported measures of patient physical and mental health as well as their social well-being. Learn more about HRQOL as it relates specifically to ESLD.
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A ‘‘Good Death’’ With Irreversible Liver Disease: Talking With Patients and Families About Deteriorating Health and Dying
Kirsty Boyd, M.B.Ch.B.(Hon.), F.R.C.P. (Edin.), M.Med.Sci., Barbara Kimbell, Ph.D., Scott Murray, M.B.Ch.B., D.C.H., M.R.C.G.P., M.D., F.R.C.G.P., F.R.C.P.Ed., John Iredale D.M., F.R.C.P., F.Med.Sci., F.R.S.E.
HRQOL is a multidimensional concept that includes self-reported measures of patient physical and mental health as well as their social well-being. Learn more about HRQOL as it relates specifically to ESLD.
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Palliative Care for Patients with End-Stage Liver Disease: An Overview
Mina O. Rakoski, M.D., M.Sc. and Michael L. Volk, M.D., M.Sc., AGAF
The debilitating complications of ESLD are associated with substantial symptom burden. What can clinicians do to optimally manage symptoms and improve patient quality of life?
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Palliative Care for Patients With End-Stage Liver Disease: The Role of the Liver Team
Sean G. Kelly, M.D. and John P. Rice, M.D.
Despite the appropriateness of palliative care in ESLD, its use remains strikingly low. Learn why, and what can we do about it.
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Is Palliative Care Appropriate in the Liver Transplant Candidate?
Rohit Pai M.D., Constantine J. Karvellas M.D., S.M.
If palliative care is appropriate for LT candidates, when and how show it be implemented? Learn more from Drs. Pai and Karvellas.
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Liver and the Microbiome
Guest Edited by Eamonn M.M. Quigley, MD, FRCP, FACP, FACG, FRCPI

Host-Microbiome Interactions in Health and Disease
Liam O’Mahony, PhD
Microbes and metabolites
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Microbiome-Immune Interactions and Liver Disease
James H. Tabibian MD, PhD, Cyril Varghese MD, Steven P. O’Hara PhD, and Nicholas F. LaRusso MD
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The Gut Microbiome: What Do We Know?
Francisco Guarner, MD, PhD
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The Metabolic Role of the Microbiota
Wiley Barton B.Sc. Fergus Shanahan MD, Paul D. Cotter PhD, Orla O’Sullivan PhD
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Is the Gut Microbiota Disturbed in Chronic Liver Disease?
Eamonn M.M. Quigley, MD, FRCP, FACP, FACG, FRCPI
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Microbiome and Complications of Liver Disease
Jasmohan S. Bajaj, MD, MS, FACG, AGAF
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Check out what's new in CLD's sister journal, HEPATOLOGY

HEPATOLOGY Highlights



Popular in our series on New Treatments for Hepatitis C

Guest Edited by Donald M. Jensen, MD, FACP

New Therapies for Hepatitis C: Latin American Perspectives
Rafael Claudino Botero, MD, FACP, and Martin Tagle, MD
Watch the interview
Learn about the unique challenges for treating Hepatitis C in Latin America, including a detailed country by country analysis.
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Prefer to learn in Spanish? Read the article or watch an interview with Dr. Botero, todo en español!

Los Nuevos Tratamiento de Hepatitis C: Perspectivas Latinoamericanas
Read the full textWatch the author interview.

The Future in Liver Medicine

Guest Edited by Meena Bansal, MD

NEW in the Future in Liver Medicine:

Liver Fibrosis: Therapeutic Armory 40 Years On
John P. Iredale, FRCP, F Med Sci, FRSE, and Antonella Pellicoro, PhD
What will management of liver fibrosis look like in 40 years? Drs. Iredale and Pellicoro look at how far we've come and where we're going, and what challenges remain.
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Histologic and Noninvasive Estimates of Liver Fibrosis
Pierre Bedossa, M.D., Ph.D., Keyur Patel, M.D., and Laurent Castera, M.D., Ph.D.
Periportal fibrosis
The severity of liver fibrosis is important in therapeutic decision-making and in predicting prognosis of chronic liver disease, so assessment will remain important, but our methods may change.
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More on the Future in Liver Medicine:

The Future of Hepatology: Embrace Change
Scott L. Friedman MD and Yael L. Friedman MA
Interview with Scott Friedman
If the astounding progress in hepatology over the past 35 years is any indication of the future, the next 35 years will advance in ways that may be unrecognizable by today’s standards.
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Training the Next Generation of Hepatologist: What Will They Need to Know?
Dina L. Halegoua-De Marzio MD, and Steven K. Herrine MD
With major changes in health care on the horizon, it's more important than ever to identify the skills hepatologists will need and what new challenges they will face.
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Personalized Management of Hepatocellular Carcinoma Based on Molecular Information: Future Prospects
Nicolas Goossens, MD, MSc Yujin Hoshida, MD, PhD
Read an overview of the evolving challenges in HCC in relation to the epidemic of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis, and the everexpanding inventories of molecular agents and genomics technologies that have enabled exploration of more personalized management of the patients.
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Increasing Impact of Drug-Induced Liver Injury
Paul H. Hayashi, MD, MPH and Naga P. Chalasani MD
Idiosyncratic drug-induced liver injury (DILI) represents one of the most challenging consultations for a hepatologist. Population incidence is likely on the rise, and for certain medications, the risk may be higher than previously recognized.
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Future Watch: Evolving Trends in the Management of Nonalcoholic Steatohepatitis
Arun J. Sanyal, MBBS, MD
Nonalcoholic steatohepatitis (NASH) has emerged as the leading etiology of chronic liver disease in the United States and is a growing problem in virtually all parts of the world.
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Non-Cirrhotic Portal Hypertension


Guest Edited by Theo Heller, MD, Ohad Etzion, MD, and Christopher Koh, MD

Surgical Management of Noncirrhotic Portal Hypertension
Josep Marti, MD, PhD, Ganesh Gunasekaran, MD, FACS, Kishore Iyer, MD, Myron Schwartz, MD
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Noncirrhotic Portal Hypertension in the Pediatric Population
Amy G. Feldman, MD, Ronald J. Sokol, MD
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Idiopathic Noncirrhotic Portal Hypertension: What Is It?
Guadalupe Garcia-Tsao, MD
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Noncirrhotic Portal Hypertension: Pathology and Nomenclature
David E. Kleiner, MD, PhD
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