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Clinical Liver Disease

Cover image for Vol. 5 Issue 3

Edited By: Michael Lucey, MD

Online ISSN: 2046-2484

Associated Title(s): Hepatology, Liver Transplantation

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NEW ISSUE: Hepatic Encephalopathy

Guest Edited by Jasmohan Bajaj, M.D.

Pathophysiological Mechanisms of Hepatic Encephalopathy
T.H. Tranah, MD, A. Paolino, MD, Debbie L. Shawcross, MD
The role of ammonia in the development of hepatic encephalopathy
Hepatic encephalopathy (HE) represents a diverse spectrum of complex neuropsychiatric disturbance. Review current understanding and ongoing research into the pathophysiological mechanisms underlying this complex neuropsychiatric condition.
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Prevention of Hepatic Encephalopathy Recurrence
Barjesh Chander Sharma, M.D., and Sudhir Maharshi, D.M.
Successive episodes of HE are associated with increased morbidity, hospitalization, health care burden, poor prognosis, and increased risk of death. What do you need to know to prevent recurrence?
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Nomenclature and Definition of Hepatic Encephalopathy — An Update
Sanath Allampati M.D., M.P.H., and Kevin D. Mullen, M.D., F.R.C.P.I.
As recently as the mid-1990s, nomenclature and definitions for hepatic encephalopathy were not standardized. How far have we come?
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Diagnosing Covert Hepatic Encephalopathy
Mette Munk Lauridsen, Hendrik Vilstrup M.D., Ph.D
When not immediately evident at clinical contact, HE is termed covert (cHE). CHE often causes disabling cognitive deficits, implies a risk for overt HE, severely affects quality of life, and poses a heavy burden on caregivers and the health care system.
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Impact of Minimal/Covert Hepatic Encephalopathy on Patients With Cirrhosis
Radha K. Dhiman, M.D., D.M., F.A.M.S., F.A.C.G.
Minimal HE is regarded as a preclinical stage of HE - know the signs and its impact on HRQOL and patient daily function.
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Management of Hepatic Encephalopathy as an Inpatient
Oliviero Riggio, Ph.D, Silvia Nardelli, M.D., Stefania Gioia, M.D., Cristina Lucidi, M.D., and Manuela Merli, Ph.D
Learn about the four-pronged approach to management of HE recommended in the 2014 EASL/AASLD Practice Guidelines for HE in chronic liver disease.
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Check out what's new in CLD's sister journal, HEPATOLOGY

HEPATOLOGY Highlights




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Series on New Treatments for Hepatitis C

Guest Edited by Donald M. Jensen, M.D., F.A.C.P.

New Therapies for Hepatitis C: Latin American Perspectives
Rafael Claudino Botero, M.D., F.A.C.P., and Martin Tagle, M.D.
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Learn about the unique challenges for treating Hepatitis C in Latin America, including a detailed country by country analysis.
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Prefer to learn in Spanish? Read the article or watch an interview with Dr. Botero, todo en español!

Los Nuevos Tratamiento de Hepatitis C: Perspectivas Latinoamericanas
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Access to New Direct-Acting Antiviral Agents Against HCV Infection: A View From Spain
Santiago Tome, M.D., Esteban Otero, M.D.
The high cost of treatment, assumptions about the need for specialized management, and patient fear all combine to make treating HCV in Spain an ongoing healthcare problem.
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Prefer to learn in Spanish? Read the article or watch an interview with Dr. Tome, todo en español!

Accesibilidad a los nuevos agentes antivirales directoscontra la infeccion por VHC. Un punto de vista desde España
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New Treatments for HCV: Perspective From Asia
Ming-Lung Yu, M.D., Ph.D., and Wan-Long Chuang, M.D., Ph.D.
More than 80% of Asian persons infected with HCV have a favorable host genotype associated with a higher rate of sustained virological response to treatment with pegylated interferon and ribavirin. What does that mean for treatment?
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Treating HCV Infection in Children
Christine K. Lee, M.D., Maureen M. Jonas, M.D.
Perinatal transmission is the most common mode of hepatitis C virus (HCV) acquisition in children - read, watch, or listen to learn more.
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Series on Liver Surgery

Guest Edited by David Reich, M.D.

NEW in Liver Surgery:

Laparoscopic distal pancreatectomy
Rizwan Ahmed M.D., Christi M. Walsh M.S.N., C.R.N.P., and Martin A. Makary M.D., M.P.H.
Laparoscopic distal pancreatectomy
Know the indications, recent advances in and proper application of technique, and the patient outcomes for laparoscopic distal pancreatectomy.
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Pylorus preserving pancreaticoduodenectomy
Jacqueline M. Garonzik-Wang, M. B. Majella Doyle
PD has become the standard of care for resectable pancreatic cancer and premalignant lesions in the periampullary region. Learn about the technique from experts, including key surgical maneuvers.
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MORE from Liver Surgery:

Liver Resection After Thermal Ablation of Parenchymal Transection Margin Using Microwave Energy
David J. Reich, M.D., F.A.C.S.
Learn how applying a zone of thermally induced necrosis at the resection margin before transection can reduce blood loss and other adverse effects.
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Laparoscopic Liver Resection
David A. Geller M.D., Mohammad Khreiss M.D.
Learn why laparoscopic liver resection is rapidly being adopted for certain benign and malignant tumors, with more than 6000 cases now performed worldwide.
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Single-Incision Laparoscopic Cholecystectomy
Figure 4
Andres Castellanos, M.D., Jessica Fazendin, M.D., and Lucian Panait, M.D.
Experts explain what clinicians need to know about the indications, technical aspects, complications, and outcomes of single-incision laparoscopic cholecystectomy.
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