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Clinical Liver Disease

Cover image for Clinical Liver Disease

Edited By: Michael Lucey, MD

Online ISSN: 2046-2484

Associated Title(s): Hepatology, Liver Transplantation

Pathology of the Liver


NakhlehRaouf E. Nakhleh, M.D., F.C.A.P
Professor of Laboratory Medicine and Pathology
Mayo Clinic

In this special issue of Clinical Liver Disease (CLD), Dr. Nakhleh brings together a team of experts in the pathology of the liver to deliver new reviews and videos addressing normal liver anatomy, microscopic anatomy of the liver, and the role of special stains in diagnostic liver pathology. He has also selected the articles, interviews, and presentations published in CLD that are most relevant to understanding the pathology of the liver.

Recent pathology content from CLD:

Normal Liver Anatomy
Lena Sibulesky, M.D.

Silbulesky Presentation

Dr. Sibulesky, in this review and video presentation of the article, reviews the nomenclature of hepatic anatomy and surgical resection.
Read the full text.Watch the article presentation.Answer questions and earn CME.

Histopathology of Alcoholic Liver Disease
Neil D. Theise, M.D.
Theise

Alcoholic liver disease is characterized by three stages of histopathological changes: steatosis, steatohepatitis, and steatofibrosis. Dr. Theise describes each stage, how histological findings may change with patient abstinence, and how to distinguish ALD from NAFLD.
Read the full text.Listen to the article presentation.Answer questions and earn CME.

Microscopic Anatomy of the Liver
Murli Krisna, M.D.

Krishna Presentation

Dr. Krisna discusses the normal microanatomy of the liver with the aim of establishing a basic understanding that will help recognize patterns of injury in liver diseases in this review and video presentation of the article.
Read the full text.Watch the article presentation.Answer questions and earn CME.

Role of Special Stains in Diagnostic Liver Pathology
Murli Krisna, M.D.


Krishna Presentation

In this review and video presentation of the article, Dr. Krisna discusses the common stains used in the evaluation of nonneoplastic liver specimens and their importance in providing information of clinical relevance.
Read the full text.Watch the article presentation.Answer questions and earn CME.


Test your knowledge of liver pathology.
Access the CLD Pathology of the Liver Practice Question Bank for a free self-assessment resource addressing concepts related to liver pathology.


Read more pathology content from CLD:

Histopathologic features of hepatocellular carcinoma
Elizabeth M. Brunt, M.D.
Article first published online: 23 JAN 2013

Histopathology of HCC

The image above displays hematoxylin and eosin (H&E)-stained images of hepatocellular carcinoma. For more images and descriptions of the histopathologic features of HCC, read the article or watch the videos.
Read the full text.Watch the article presentation.Watch the article presentation.Answer questions and earn CME.

Histological Assessment of Nonalcoholic Fatty Liver Disease in Adults and Children
Elizabeth M. Brunt, MD
Article first published online: 25 SEP 2012

Histopathology of NAFLD

Adult NASH: Delicate strands of collagen can be seen in this example of zone 3 perisinusoidal fibrosis. For more images and a discussion of the histological assessment of nonalcoholic fatty liver disease in adults and children, read the article or watch the videos.
Read the full text.Watch the author interview.Answer questions and earn CME.

Hepatopathology of hepatitis B
Zachary D. Goodman, M.D., Ph.D.
Article first published online: 1 MAR 2013

Hepatopathology of Hep B

This liver biopsy from a patient with a severe flare shows hepatocellular ballooning and apoptosis, hypertrophied Kupffer cells, sinusoidal lymphocytes, and a few binucleate regenerating hepatocytes. For more images and a discussion of the hepatopathology of hepatitis B, read the article or watch the videos.
Read the full text.Watch the article presentation.Answer questions and earn CME.

Is There Still a Role for Liver Biopsy in Managing Hepatitis C Virus Infections?
Syed-Mohammed R. Jafri, M.D. and Stuart C. Gordon, M.D.
Article first published online: 26 APR 2012

Liver Biopsy of Hep C

The image above displays sustained virological response rates by the degree of fibrosis in the REALIZE trial. For a full discussion of the potential role for liver biopsy in managing hepatitis C, read the article or watch the videos.
Read the full text.Watch the author interview.Watch the article presentation.Answer questions and earn CME.

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