Clinical Liver Disease
© 2014 The American Association for the Study of Liver Diseases
Pathology of the Liver
|Raouf E. Nakhleh, M.D., F.C.A.P|
Professor of Laboratory Medicine and Pathology
In this special issue of Clinical Liver Disease (CLD), Dr. Nakhleh brings together a team of experts in the pathology of the liver to deliver new reviews and videos addressing normal liver anatomy, microscopic anatomy of the liver, and the role of special stains in diagnostic liver pathology. He has also selected the articles, interviews, and presentations published in CLD that are most relevant to understanding the pathology of the liver.
Recent pathology content from CLD:
Normal Liver Anatomy
Histopathology of Alcoholic Liver Disease
Alcoholic liver disease is characterized by three stages of histopathological changes: steatosis, steatohepatitis, and steatofibrosis. Dr. Theise describes each stage, how histological findings may change with patient abstinence, and how to distinguish ALD from NAFLD.
Microscopic Anatomy of the Liver
Dr. Krisna discusses the normal microanatomy of the liver with the aim of establishing a basic understanding that will help recognize patterns of injury in liver diseases in this review and video presentation of the article.
| Role of Special Stains in Diagnostic Liver Pathology|
Murli Krisna, M.D.
In this review and video presentation of the article, Dr. Krisna discusses the common stains used in the evaluation of nonneoplastic liver specimens and their importance in providing information of clinical relevance.
Test your knowledge of liver pathology.
Access the CLD Pathology of the Liver Practice Question Bank for a free self-assessment resource addressing concepts related to liver pathology.
Read more pathology content from CLD:
Histopathologic features of hepatocellular carcinoma
The image above displays hematoxylin and eosin (H&E)-stained images of hepatocellular carcinoma. For more images and descriptions of the histopathologic features of HCC, read the article or watch the videos.
Histological Assessment of Nonalcoholic Fatty Liver Disease in Adults and Children
Adult NASH: Delicate strands of collagen can be seen in this example of zone 3 perisinusoidal fibrosis. For more images and a discussion of the histological assessment of nonalcoholic fatty liver disease in adults and children, read the article or watch the videos.
Hepatopathology of hepatitis B
This liver biopsy from a patient with a severe flare shows hepatocellular ballooning and apoptosis, hypertrophied Kupffer cells, sinusoidal lymphocytes, and a few binucleate regenerating hepatocytes. For more images and a discussion of the hepatopathology of hepatitis B, read the article or watch the videos.
Is There Still a Role for Liver Biopsy in Managing Hepatitis C Virus Infections?
The image above displays sustained virological response rates by the degree of fibrosis in the REALIZE trial. For a full discussion of the potential role for liver biopsy in managing hepatitis C, read the article or watch the videos.