Immunity, Inflammation and Disease

Cover image for Vol. 3 Issue 1

Early View (Online Version of Record published before inclusion in an issue)

Editor-in-Chief Dr. Marc Veldhoen

Online ISSN: 2050-4527


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  1. Original Research

    1. Cell extrinsic alterations in splenic B cell maturation in Flt3-ligand knockout mice

      Joseph J. Dolence, Kimberly A. Gwin, Mariya B. Shapiro, Fan-Chi Hsu, Virginia S. Shapiro and Kay L. Medina

      Article first published online: 15 APR 2015 | DOI: 10.1002/iid3.54

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      MFlt3 signaling regulates B cell production in bone marrow and deficiency in Flt3-ligand (FL) alters select B cell subsets in the spleen. Mice deficient in Flt3-ligand (FL-/-) have reduced production of immature B cells in bone marrow and consequently have fewer transitional (TS) B cells in the spleen. Reduced B cell output from the marrow favors the generation of marginal zone (MZ) B cells to provide a source of natural antibody to fight infection. FL replacement therapy restores immature B cell output from the marrow and normalizes the TS and MZ compartments in the spleen. These findings imply that the distribution of B cell subsets in the spleen is not static, but dictated by production in marrow. These findings have implications for alterations in B cell subsets in immunodeficiency diseases, regeneration of the peripheral B cell compartment after marrow ablation, or upon aging.e.

    2. You have full text access to this OnlineOpen article
      Depletion of alveolar macrophages in CD11c diphtheria toxin receptor mice produces an inflammatory response

      Lydia M. Roberts, Hannah E. Ledvina, Shraddha Tuladhar, Deepa Rana, Shaun P. Steele, Gregory D. Sempowski and Jeffrey A. Frelinger

      Article first published online: 23 MAR 2015 | DOI: 10.1002/iid3.51

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      Intranasal treatment of CD11c.DOG mice with diphtheria toxin depletes alveolar macrophages while leaving systemic dendritic cells intact. However, alveolar macrophage depletion is accompanied by numerous changes to the cellular composition and cytokine milieu of the lung. The multitude of changes after diphtheria toxin treatment rendered it impossible to effectively differentiate differences seen in the immune response due to the loss of alveolar macrophages and serve as a cautionary tale for other researchers using this model.

  2. Original Researchs

    1. You have full text access to this OnlineOpen article
      Humoral responses to HIVconsv induced by heterologous vaccine modalities in rhesus macaques

      Nicola J. Borthwick, Maximillian Rosario, Torben Schiffner, Emma Bowles, Tina Ahmed, Peter Liljeström, Guillaume E. Stewart-Jones, Jan W. Drijfhout, Cornelis J. M. Melief and Tomáš Hanke

      Article first published online: 11 MAR 2015 | DOI: 10.1002/iid3.52

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      The humoral immune response was evaluated in macaques immunised with a vaccine composed of the most conserved regions of HIV-1 and delivered by plasmid DNA, human adenovirus serotype 5, simian adenovirus serotype 63, MVA, Semliki Forest virus replicons and adjuvanted overlapping synthetic long peptides (SLP). We found that only the SLP formulation, but none of the genetic vaccine platforms induced antibodies recognizing linear HIVconsv epitopes, median 32/46 SLP.HIVconsv peptides. These antibodies bound to 15-mer and SLP peptides, recombinant gp120 and trimeric gp140 of HIV-1 Bal, YU2, JRFL and UG037, but failed to react with HIV-1 Bal and IIIB virions and HIV-1 Bal- and IIIB-infected human cells, and consequently failed to induce neutralizing antibodies. Antibodies induced by the SLP.HIVconsv vaccination resulted in positive signals in routine HIV-1 tests, an observation that provides important guidance for recruiting volunteers into future clinical trials.

  3. Original Research

    1. You have full text access to this OnlineOpen article
      Immune parameters of patients treated with laquinimod, a novel oral therapy for the treatment of multiple sclerosis: results from a double-blind placebo-controlled study

      Mariusz Stasiolek, Ralf A. Linker, Liat Hayardeny, Oren Bar Ilan and Ralf Gold

      Article first published online: 4 MAR 2015 | DOI: 10.1002/iid3.42

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      The laquinimod treatment in relapsing-remising MS patients exerts immunomodulatory but not immunosuppressive biological activity. Importantly, the laquinimod associated regulatory mechanisms seemed to be specific for particular immune cell populations, especially monocytes and strongly depend on the type of inflammatory stimulation including innate immunity signals.

  4. Original Researchs

    1. You have full text access to this OnlineOpen article
      The proportion of CD16+CD14dim monocytes increases with tumor cell load in bone marrow of patients with multiple myeloma

      Anne M. Sponaas, Siv H. Moen, Nina B. Liabakk, Emadoldin Feyzi, Toril Holien, Solveig Kvam, Lill Anny G. Grøseth, Berit Størdal, Glenn Buene, Terje Espevik, Anders Waage, Therese Standal and Anders Sundan

      Article first published online: 2 MAR 2015 | DOI: 10.1002/iid3.53

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      We have characterized monocytes in bone marrow aspirates from myeloma patients by multi-colour flow cytometry and found that there was significant correlation between the proportion of CX3CR1+, CD16+CD14dim non-classical monocytes and percent plasma cells (PC) in the bone marrow of these patients. The proportion of the non-classical monocytes increased with the tumor load, in particularly in patients with moderate tumor loads.

  5. Original Research

    1. You have full text access to this OnlineOpen article
      Differences in immune responses between CMV-seronegative and -seropositive patients with myocardial ischemia and reperfusion

      Evgeniya V. Shmeleva, Stephen E. Boag, Santosh Murali, Karim Bennaceur, Rajiv Das, Mohaned Egred, Ian Purcell, Richard Edwards, Stephen Todryk and Ioakim Spyridopoulos

      Article first published online: 1 MAR 2015 | DOI: 10.1002/iid3.49

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      The immune response during acute myocardial infarction showed characteristic differences between CMV seronegative and seropositive patients, with a stronger pro-inflammatory response in seropositive patients. The effects of IP-10, IL-16 and IL-10 on characteristics of acute immune responses and formation of different immune profiles in CMV-seropositive individuals require further investigation.

    2. You have full text access to this OnlineOpen article
      Midline 1 controls polarization and migration of murine cytotoxic T cells

      Lasse Boding, Ann K. Hansen, Morten M. Nielsen, Germana Meroni, Thomas H. Braunstein, Anders Woetmann, Niels Ødum, Charlotte M. Bonefeld and Carsten Geisler

      Article first published online: 17 DEC 2014 | DOI: 10.1002/(ISSN)iid3.38.44

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      Midline 1 (MID1) is a microtubule-associated ubiquitin ligase that regulates protein phosphatase 2A levels. Here we show that MID1 mainly localizes to the uropod of migrating cytotoxic T lymphocytes (CTLs),and that it has a substantial impact on CTL polarization and migration in vitro. Furthermore, analysis of contact hypersensitivity responses supported that MID1 controls effector functions of CTLs in hapten-challenged skin in vivo.


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