Reliable measurements of brain atrophy in individual patients with multiple sclerosis
Dirk Smeets, Annemie Ribbens, Diana M. Sima, Melissa Cambron, Dana Horakova, Saurabh Jain, Anke Maertens, Eline Van Vlierberghe, Vasilis Terzopoulos, Anne-Marie Van Binst, Manuela Vaneckova, Jan Krasensky, Tomas Uher, Zdenek Seidl, Jacques De Keyser, Guy Nagels, Johan De Mey, Eva Havrdova and Wim Van Hecke
Version of Record online: 19 JUL 2016 | DOI: 10.1002/brb3.518
The manuscript highlights the importance of the measurement error for the translation of brain atrophy (measured on MRI) from clinical research (group level) to clinical practice (individual level). We also describe a method that is able to bridge this gap. We believe the translation is essential for neuroimaging research and will have a huge impact in clinical neurology and neuroradiology.