Brain and Behavior

Cover image for Vol. 3 Issue 3

Early View (Online Version of Record published before inclusion in an issue)

Edited By: Andrei V. Alexandrov, University of Alabama at Birmingham, USA and Maryann Martone, University of California, San Diego, USA

Online ISSN: 2162-3279

  1. Original Research

    1. You have full text access to this OnlineOpen article
      Effect of language task demands on the neural response during lexical access: a functional magnetic resonance imaging study

      Gabriela Gan, Christian Büchel and Frédéric Isel

      Article first published online: 1 MAY 2013 | DOI: 10.1002/brb3.133

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      To clarify the functional role of the inferior frontal gyrus (IFG) for semantic processing with respect to semantic decision making compared to semantic processing per se, we used a linguistic task that involved either a binary decision process (i.e., semantic categorization; Experiment 1) or not (silently thinking about a word's meaning; Experiment 2). With the present functional magnetic resonance imaging (fMRI) study, we showed that the same left-lateralized temporo-frontal network including the IFG is recruited during lexical-semantic processing irrespective of linguistic task demands. The present findings give rise to the assumption that activation of the IFG in the semantic domain might be important for semantic processing in general and not only for semantic decision making.

    2. You have full text access to this OnlineOpen article
      An fMRI investigation of delay discounting in patients with schizophrenia

      Kathy Burton Avsar, Rosalyn Eve Weller, James Edward Cox, Meredith Amanda Reid, David Matthew White and Adrienne Carol Lahti

      Article first published online: 24 APR 2013 | DOI: 10.1002/brb3.135

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      fMRI in patients with schizophrenia was performed during a delay-discounting task. Patients compared with matched controls showed increased task-related activation in regions of the DMN and reduced activation in regions associated with executive, reward, and emotional networks.

    3. You have full text access to this OnlineOpen article
      B6eGFPChAT mice overexpressing the vesicular acetylcholine transporter exhibit spontaneous hypoactivity and enhanced exploration in novel environments

      Paul M. Nagy and Isabelle Aubert

      Article first published online: 17 APR 2013 | DOI: 10.1002/brb3.139

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      Cholinergic innervation is extensive throughout the central and peripheral nervous systems. We used the hypercholinergic B6eGFPChAT congenic mouse model, shown to overexpression the vesicular acetylcholine transporter (VAChT), and present data to suggest that modest increases in VAChT expression can have a significant effect on spontaneous locomotion, reaction to novel stimuli and the adaptation to novel environments.

    4. You have full text access to this OnlineOpen article
      A phenotypic model recapitulating the neuropathology of Parkinson's disease

      Craig F. Ferris, Mathieu Marella, Brian Smerkers, Thomas M. Barchet, Benjamin Gershman, Akemi Matsuno-Yagi and Takao Yagi

      Article first published online: 17 APR 2013 | DOI: 10.1002/brb3.138

      Thumbnail image of graphical abstract

      This is a model of Parkinson's disease in rats recapitulating all of the molecular and cellular biomarkers associated with human disease including Lewy bodies.

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