Synergistic association of STX1A and VAMP2 with cryptogenic epilepsy in North Indian population
Ruchi Baghel, Sandeep Grover, Harpreet Kaur, Ajay Jajodia, Shama Parween, Juhi Sinha, Ankit Srivastava, Achal Kumar Srivastava, Kiran Bala, Puneet Chandna, Suman Kushwaha, Rachna Agarwal and Ritushree Kukreti
Version of Record online: 14 JUN 2016 | DOI: 10.1002/brb3.490
We hypothesize the involvement of genetic variants from synaptic vesicle cycle (presynapse), ion channels and their functionally related genes (postsynapse) in pathophysiology of epilepsy. A highly significant interactive two-locus model of STX1A_rs4363087|VAMP2_rs2278637 was observed in cryptogenic epilepsy (Corrected P = 0.012; CVC = 10/10; OR = 4.59, 95% CI = 2.57–8.22), thus revealing the possible functional relatedness of presynapse with pathophysiology of cryptogenic epilepsy.