Reproducibility of tract-based white matter microstructural measures using the ENIGMA-DTI protocol
Ashley Acheson, S. Andrea Wijtenburg, Laura M. Rowland, Anderson Winkler, Charles W. Mathias, L. Elliot Hong, Neda Jahanshad, Binish Patel, Paul M. Thompson, Stephen A. McGuire, Paul M. Sherman, Peter Kochunov and Donald M. Dougherty
Version of Record online: 14 JAN 2017 | DOI: 10.1002/brb3.615
In preparation for longitudinal analyses of white matter development in youths with family histories of substance use disorders (FH+) or without such histories (FH−), we examined the reproducibility and reliability of global and regional measures of fractional anisotropy (FA) values, measured using the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA)-diffusion tensor imaging (DTI) protocol in data collected a year apart in 68 FH+ and 21 FH− adolescents. Overall, this study demonstrated an excellent reproducibility of ENIGMA-DTI FA, positing it as viable analysis tools for longitudinal studies and other protocols that repeatedly assess white matter microstructure.