ChemistryOpen

Articles are published under the terms of the Creative Commons License as stated in the final article.

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Editors: Karen Hindson, Haymo Ross; Deputy Editor: Natalia Ortúzar

Online ISSN: 2191-1363

Associated Title(s): Angewandte Chemie International Edition, Chemistry - A European Journal, Chemistry – An Asian Journal

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ChemistryOpen covers all aspects of chemistry, including the exciting interface to the life sciences. Read the latest articles:

Barbara Ganisl, Kathrin Breuker
Does Electron Capture Dissociation Cleave Protein Disulfide Bonds? [Full Paper]
ChemistryOpen2012, 1, 260–268.
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Estela Climent, Ramón Martínez-Máñez, Angel Maquieira, Félix Sancenón, M. Dolores Marcos, Eva M. Brun, Juan Soto, Pedro Amorós
Antibody-Capped Mesoporous Nanoscopic Materials: Design of a Probe for the Selective Chromo-Fluorogenic Detection of Finasteride [Full Paper]
ChemistryOpen2012, 1, 251–259.
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Anna Svitova, Klaus Braun, Alexey A. Popov, Lothar Dunsch
A Platform for Specific Delivery of Lanthanide–Scandium Mixed-Metal Cluster Fullerenes into Target Cells [Communication]
ChemistryOpen2012, 1, 207–210.
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Recently Published Articles

  1. You have full text access to this OnlineOpen article
    Rapid Microfluidic Immunoassays of Cancer Biomarker Proteins Using Disposable Inkjet-Printed Gold Nanoparticle Arrays

    Colleen E. Krause, Brunah A. Otieno, Dr. Alina Latus, Dr. Ronaldo C. Faria, Dr. Vyomesh Patel, Dr. J. Silvio Gutkind and Dr. James F. Rusling

    Article first published online: 12 JUN 2013 | DOI: 10.1002/open.201300018

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    Off-line amplification: A low-cost inkjet-printed gold nanoparticle immunoarray was integrated into a microfluidic device for multiple protein determinations. The use of heavily labeled magnetic beads allows optimization either for ultrasensitive detection of biomarker proteins (low fg mL−1 levels) or for rapid 8 min assays within clinically relevant detection ranges.

  2. You have full text access to this OnlineOpen article
    Incorporation of Bulky and Cationic Cyclam-Triazole Moieties into Marimastat Can Generate Potent MMP Inhibitory Activity without Inducing Cytotoxicity (pages 99–105)

    Mingfeng Yu, Dr. Ngee H. Lim, Samantha Ellis, Prof. Hideaki Nagase, Prof. James A. Triccas, Dr. Peter J. Rutledge and Dr. Matthew H. Todd

    Article first published online: 12 JUN 2013 | DOI: 10.1002/open.201300014

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    Choices, choices: A conjugate of cyclam and the matrix metalloproteinase (MMP) inhibitor marimastat was synthesized to give a compound with two potential zinc-binding groups (ZBGs). The first equivalent of Cu(II) or Zn(II) was chelated by the cyclam-triazole moiety rather than the hydroxamic acid. Both the conjugate and its metal complexes exhibited potent and selective MMP inhibitory activity, and displayed no cytotoxicity, suggesting future applications in the imaging of MMP activity.

  3. You have full text access to this OnlineOpen article
    Benchmark Study of the Performance of Density Functional Theory for Bond Activations with (Ni,Pd)-Based Transition-Metal Catalysts (pages 115–124)

    Marc Steinmetz and Stefan Grimme

    Article first published online: 3 JUN 2013 | DOI: 10.1002/open.201300012

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    Catch 23: An extensive benchmark for evaluating modern density functionals in transition-metal-catalyzed bond-activation reactions is presented. The study focuses on the class of sophisticated double-hybrid functionals and finds dispersion-corrected PWPB95 and PBE0 as the most robust and well-performing methods.

  4. You have full text access to this OnlineOpen article
    Synthesis and Characterization of Fe10BO3/Fe3O4/SiO2 and GdFeO3/Fe3O4/SiO2: Nanocomposites of Biofunctional Materials (pages 88–92)

    Prof. Shanmin Gao, Xin Liu, Prof. Tao Xu, Xuehua Ma, Prof. Zheyu Shen, Prof. Aiguo Wu, Dr. Yinghuai Zhu and Prof. Narayan S. Hosmane

    Article first published online: 13 MAY 2013 | DOI: 10.1002/open.201300007

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    The sum of its parts: Nanocomposites of Fe10BO3/Fe3O4/SiO2 and GdFeO3/Fe3O4/SiO2, synthesized by a gel combustion technique using citric acid as fuel and chelation, exhibited strong magnetic properties indicating that they might have potential applications in diagnostic analysis of cancer through use in neutron capture therapy.

  5. You have full text access to this OnlineOpen article
    Nonlinear d10-ML2 Transition-Metal Complexes (pages 106–114)

    Lando P. Wolters and Prof. Dr. F. Matthias Bickelhaupt

    Article first published online: 6 MAY 2013 | DOI: 10.1002/open.201300009

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    π Electrons can do that! They can bend the otherwise linear d10-ML2 complexes through backbonding. Bonding analyses reveal that the second π-accepting ligand is, in a sense, hunting for “fresh” (not yet stabilized) dπ electrons. The magnitude of the effect depends on the nature of both metal and ligand; L[BOND]M[BOND]L angles adopt values as small as 128.6°.

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