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Recently Published Articles
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Colleen E. Krause, Brunah A. Otieno, Dr. Alina Latus, Dr. Ronaldo C. Faria, Dr. Vyomesh Patel, Dr. J. Silvio Gutkind and Dr. James F. Rusling
Article first published online: 12 JUN 2013 | DOI: 10.1002/open.201300018
Off-line amplification: A low-cost inkjet-printed gold nanoparticle immunoarray was integrated into a microfluidic device for multiple protein determinations. The use of heavily labeled magnetic beads allows optimization either for ultrasensitive detection of biomarker proteins (low fg mL−1 levels) or for rapid 8 min assays within clinically relevant detection ranges.
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Mingfeng Yu, Dr. Ngee H. Lim, Samantha Ellis, Prof. Hideaki Nagase, Prof. James A. Triccas, Dr. Peter J. Rutledge and Dr. Matthew H. Todd
Article first published online: 12 JUN 2013 | DOI: 10.1002/open.201300014
Choices, choices: A conjugate of cyclam and the matrix metalloproteinase (MMP) inhibitor marimastat was synthesized to give a compound with two potential zinc-binding groups (ZBGs). The first equivalent of Cu(II) or Zn(II) was chelated by the cyclam-triazole moiety rather than the hydroxamic acid. Both the conjugate and its metal complexes exhibited potent and selective MMP inhibitory activity, and displayed no cytotoxicity, suggesting future applications in the imaging of MMP activity.
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Marc Steinmetz and Stefan Grimme
Article first published online: 3 JUN 2013 | DOI: 10.1002/open.201300012
Catch 23: An extensive benchmark for evaluating modern density functionals in transition-metal-catalyzed bond-activation reactions is presented. The study focuses on the class of sophisticated double-hybrid functionals and finds dispersion-corrected PWPB95 and PBE0 as the most robust and well-performing methods.
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Prof. Shanmin Gao, Xin Liu, Prof. Tao Xu, Xuehua Ma, Prof. Zheyu Shen, Prof. Aiguo Wu, Dr. Yinghuai Zhu and Prof. Narayan S. Hosmane
Article first published online: 13 MAY 2013 | DOI: 10.1002/open.201300007
The sum of its parts: Nanocomposites of Fe10BO3/Fe3O4/SiO2 and GdFeO3/Fe3O4/SiO2, synthesized by a gel combustion technique using citric acid as fuel and chelation, exhibited strong magnetic properties indicating that they might have potential applications in diagnostic analysis of cancer through use in neutron capture therapy.
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Lando P. Wolters and Prof. Dr. F. Matthias Bickelhaupt
Article first published online: 6 MAY 2013 | DOI: 10.1002/open.201300009
π Electrons can do that! They can bend the otherwise linear d10-ML2 complexes through backbonding. Bonding analyses reveal that the second π-accepting ligand is, in a sense, hunting for “fresh” (not yet stabilized) dπ electrons. The magnitude of the effect depends on the nature of both metal and ligand; LML angles adopt values as small as 128.6°.