Triostin A Derived Cyclopeptide as Architectural Template for the Alignment of Four Recognition Units
Ursula M. Kotyrba, Dr. Kevin Pröpper, Dr. Eike-F. Sachs, Anastasiya Myanovska, Tobias Joppe, Friederike Lissy, Prof. Dr. George M. Sheldrick, Prof. Dr. Konrad Koszinowski and Prof. Dr. Ulf Diederichsen
Article first published online: 9 JUL 2014 | DOI: 10.1002/open.201400001
Designed to match! Four nucleobases were attached to the disulfide bridged cyclopeptide scaffold derived from the DNA bisintercalator triostin. The aza-TANDEM backbone provides organization and alignment of the nucleobases, allowing for application in sequence-dependent DNA recognition and molecular architecture.