ChemistryOpen

Cover image for Vol. 4 Issue 1

Early View (Online Version of Record published before inclusion in an issue)

Editors: Karen Hindson, Haymo Ross; Deputy Editor: Natalia Ortúzar

Impact Factor: 2.938

ISI Journal Citation Reports © Ranking: 2013: 44/148 (Chemistry Multidisciplinary)

Online ISSN: 2191-1363

Associated Title(s): Angewandte Chemie International Edition, Chemistry - A European Journal, Chemistry – An Asian Journal

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  1. 1 - 35
  1. Full Papers

    1. You have full text access to this OnlineOpen article
      Surfactant-Free and Controlled Synthesis of Hexagonal CeVO4 Nanoplates: Photocatalytic Activity and Superhydrophobic Property

      Xiaojuan Yang, Wenli Zuo, Dr.  Feng Li and Dr.  Taohai Li

      Article first published online: 30 MAR 2015 | DOI: 10.1002/open.201402163

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      Nanoplates to go! Nanomaterials with superhydrophobic surface properties as well as photocatalytic activities could have important applications. CeVO4 hexagonal nanoplates were synthesized under simple and mild conditions. Solutions of the nanoparticles could photocatalytically degrade rhodamine B dye. The nanoplates were also used to coat glass substrates, forming superhydrophobic surfaces, with contact angles reaching 169.5 °.

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      Tetra- versus Pentavalent Inhibitors of Cholera Toxin

      Ou Fu, Dr. Aliaksei V. Pukin, H. C. Quarles van Ufford, Dr. Thomas R. Branson, Dr. Dominique M. E. Thies-Weesie, Dr.  W. Bruce Turnbull, Dr. Gerben M. Visser and Prof. Dr. Roland J. Pieters

      Article first published online: 21 MAR 2015 | DOI: 10.1002/open.201500006

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      Carbohydrates combating cholera! Simultaneous binding of the five B-subunits of the cholera toxin (CTB5) enhances its affinity and facilitates its cellular entry. Thus, blocking the toxins initial attachment to the cell surface could stop the disease. The binding pattern and potency of tetra- and pentavalent CTB5 inhibitors based on the same GM1 ganglioside scaffold are compared for the first time.

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      Solvent-Tuned Self-Assembled Nanostructures of Chiral l/d-Phenylalanine Derivatives of Protoporphyrin IX

      Mr. Sharad R. Bobe, Dr. Mohammad Al Kobaisi, Sheshanath V. Bhosale and Dr. Sidhanath V. Bhosale

      Article first published online: 14 MAR 2015 | DOI: 10.1002/open.201500011

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      Porphyrin self-assembly: We used l- and d-phenylalanine to modify protoporphyrin IX into methyl l/d-phenylalanine diamideprotoporphyrin IX (1 and 2). Solvophobic-controlled self-assembly of these chiral peptide—porphyrin derivatives led to the formation of nanostructures of various morphologies: spheres, nanofibers, lamellar structures, and thread-like and spherical shells.

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      Functionalization of a Rigid Divalent Ligand for LecA, a Bacterial Adhesion Lectin

      Ou Fu, Dr. Aliaksei V. Pukin, H. C. Quarles van Ufford, Dr. Johan Kemmink, Dr. Nico J. de Mol and Prof. Dr. Roland J. Pieters

      Article first published online: 9 MAR 2015 | DOI: 10.1002/open.201402171

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      Linkers for lectin ligands! The P. aeruginosa lectin and virulence factor LecA can be efficiently blocked by divalent galactoside ligands containing a rigid spacer. Further functionalization of the spacer was explored in order to foster spacer–protein interactions. Positively and negatively charged groups as well as lipophilic groups were used for this purpose.

  2. Communications

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      Self-Assembled Functionalized Graphene Nanoribbons from Carbon Nanotubes

      Eunice Cunha, Prof. Maria Fernanda Proença, Prof. Florinda Costa, António J. Fernandes, Marta A. C. Ferro, Dr. Paulo E. Lopes, Dr. Mariam González-Debs, Dr. Manuel Melle-Franco, Dr. Francis Leonard Deepak and Dr. Maria C. Paiva

      Article first published online: 9 MAR 2015 | DOI: 10.1002/open.201402135

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      Ribbons from tubes: Pyrrolidine-functionalized graphene nanoribbons were observed to assemble into few-layer stacks. The interlayer distance was measured by transmission electron microscopy and X-ray diffraction, and calculated by computer modelling, to be approximately 0.5 nm. The nanoribbons were obtained by unzipping of functionalized carbon nanotubes.

  3. Full Papers

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      The Role of Aromaticity, Hybridization, Electrostatics, and Covalency in Resonance-Assisted Hydrogen Bonds of Adenine—Thymine (AT) Base Pairs and Their Mimics

      L. Guillaumes, Dr. S. Simon and Dr. C. Fonseca Guerra

      Article first published online: 9 MAR 2015 | DOI: 10.1002/open.201402132

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      σ beats π! Hydrogen bonds play a crucial role in many biochemical processes. We show quantum chemically that neither aromaticity nor π assistance is responsible for the enhanced stability of the H-bonds in adenine–thymine DNA base pairs. Our bonding analyses reveal that stronger lone pair to σ* N−H donor–acceptor interactions are behind the enhanced and contracted H-bonds between aromatic and other unsaturated model bases, as compared with fully saturated analogs.

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      Computational Exploration of the Photoprotective Potential of Gadusol

      Raúl Losantos, Dr. M. Sandra Churio and Dr. Diego Sampedro

      Article first published online: 9 MAR 2015 | DOI: 10.1002/open.201402125

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      Sunscreen computed: Gadusol is one of the simplest natural UV-absorbing compounds in aquatic organisms. A detailed CASPT2//CASSCF theoretical study describes the underlying features responsible for the photoprotective capacity of gadusol, which very efficiently dissipates light energy as heat. This study provides insight for the design of new synthetic sunscreens.

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      Colorimetric Cyanide Chemosensor Based on 1′,3,3′,4-Tetrahydrospiro[chromene-2,2′-indole]

      Miglė Dagilienė, Prof. Vytas Martynaitis, Vilija Kriščiūnienė, Dr. Sonata Krikštolaitytė and Prof. Algirdas Šačkus

      Article first published online: 19 FEB 2015 | DOI: 10.1002/open.201402117

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      Cyanide before your eyes! A new type of cyanide chemosensor based on the 1′,3,3′,4-tetrahydrospiro-[chromene-2,2′-indole] scaffold is reported. These compounds show a distinct color change visible to the naked eye when treated with cyanide and exhibit high sensitivity, selectivity, and fast response within tens of seconds.

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      Sol-Gel Microspheres Doped with Glycerol: A Structural Insight in Light of Forthcoming Applications in the Polyurethane Foam Industry

      Rosaria Ciriminna, Dr. Alexandra Fidalgo, Prof. Laura M. Ilharco and Dr. Mario Pagliaro

      Article first published online: 19 FEB 2015 | DOI: 10.1002/open.201402107

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      Blasting organosilica microspheres: Porous silica-based microspheres containing glycerol can be curing agents for foams. An easy and scalable sol-gel process was used to make organosilica microspheres doped with glycerol. The structure reveals glycerol is efficiently encapsulated, acts as a template, barely leaches, but is released by depressurization. These microspheres can later be used as high-quality environment-friendly solid curing agents for spray polyurethane foams.

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      Gold(III)–pyrrolidinedithiocarbamato Derivatives as Antineoplastic Agents

      Dr. Chiara Nardon, Dr. Federica Chiara, Leonardo Brustolin, Dr. Alberto Gambalunga, Dr. Francesco Ciscato, Dr. Andrea Rasola, Prof. Andrea Trevisan and Prof. Dolores Fregona

      Article first published online: 19 FEB 2015 | DOI: 10.1002/open.201402091

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      Gold versus cancer! We report here on the synthesis, physico-chemical characterization, and solution behavior of two gold(III) pyrrolidinedithiocarbamates (PDT): [AuIIIBr2(PDT)] and [AuIIICl2(PDT)], with the bromide compound being more cytotoxic towards different cancer cell lines. A chemical and biological evaluation of the bromide compound shows it is able to trigger a ROS cascade, which possibly lead to apoptosis from the opening of the permeability transition pore.

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      A New Fluorescence Turn-On Probe for Aluminum(III) with High Selectivity and Sensitivity, and its Application to Bioimaging

      Dr. Yi Jiang, Lei-Li Sun, Guang-Zong Ren, Xiang Niu, Wen-zhou Hu and Prof. Zhi-Qiang Hu

      Article first published online: 19 FEB 2015 | DOI: 10.1002/open.201402169

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      Sensing Al! Selective, sensitive fluorescent probes for Al3+ are need given the importance of this metal in biological processes. Herein, a readily available turn-on fluorescent chemosensor is reported, which displays highly selective and sensitive Al3+-amplified fluorescence emission over other common metal ions and is able to detect Al3+ in E. coli via bioimaging.

  4. Communications

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      Development of a Wavelength-Shifting Fluorescent Module for the Adenosine Aptamer Using Photostable Cyanine Dyes

      Heidi-Kristin Walter, Peggy R. Bohländer and Prof. Dr. Hans-Achim Wagenknecht

      Article first published online: 12 FEB 2015 | DOI: 10.1002/open.201402137

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      Split and recombine: A DNA-based aptasensor for adenosine is described. The optical module is attached to the left side of the recognition module and combines a green emitting dye as an energy donor and a red emitting dye as an energy acceptor to allow fluorescent color readout of adenosine binding.

  5. Full Papers

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      Preparation and Characterization of Chitosan Thin Films on Mixed-Matrix Membranes for Complete Removal of Chromium

      Vignesh Nayak, Mannekote Shivanna Jyothi, Prof. R. Geetha Balakrishna, Dr. Mahesh Padaki and Prof. Ahmad Fauzi Ismail

      Article first published online: 12 FEB 2015 | DOI: 10.1002/open.201402133

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      Cleaning up! Chitosan thin films were developed on polysulfone/TiO2 composite membranes and were characterized by IR spectroscopy, XRD, SEM, contact angle measurement, and water uptake studies. The resulting membranes were used for the reduction of toxic CrVI to CrIII, which can then be adsorbed to the surface. This technique will facilitate the removal of toxic CrIV species from polluted water sources.

  6. Communications

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      ‘Nano-impacts’: An Electrochemical Technique for Nanoparticle Sizing in Optically Opaque Solutions

      Her Shuang Toh and Prof. Richard G. Compton

      Article first published online: 10 FEB 2015 | DOI: 10.1002/open.201402161

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      Small events with big impact! The ‘nano-impacts’ technique was shown to be a feasible method for silver nanoparticle detection and size determination in optically opaque medium, such as a solution containing a large amount of alumina, where tradition in situ methods fail. This confers the ‘nano-impacts’ technique a strong advantage over optical methods that are unable to process optically opaque samples.

  7. Full Papers

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      Trichocyanines: a Red-Hair-Inspired Modular Platform for Dye-Based One-Time-Pad Molecular Cryptography

      Dr. Loredana Leone, Dr. Alessandro Pezzella, Prof. Orlando Crescenzi, Prof. Alessandra Napolitano, Prof. Vincenzo Barone and Prof. Marco d'Ischia

      Article first published online: 5 FEB 2015 | DOI: 10.1002/open.201402164

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      Color-coded chemical cryptography: A versatile dye platform could generate an expandable palette of colors specifically suited to implement an unprecedented single-use asymmetric molecular cryptography (MoCryp) system. Eight representative acidichromic cyanine-type dyes were used in the system. The trichocyanine dyes, originally inspired by red hair pigments, were pH-sensitive and tunable through four different control points.

  8. Communications

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      Design and Synthesis of Mixed Oligomers with Thiophenes, Dithienothiophene S,S-Dioxides, Thieno[3,4]pyrazines and 2,1,3-Benzothiadiazoles: Flipper Screening for Mechanosensitive Systems

      Quentin Verolet, Saeideh Soleimanpour, Dr. Kaori Fujisawa, Dr. Marta Dal Molin, Dr. Naomi Sakai and Prof. Stefan Matile

      Article first published online: 5 FEB 2015 | DOI: 10.1002/open.201402139

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      Fluorescent flippers: Mixed oligomers containing dithienothiophene S,S-dioxides, thieno[3,4]pyrazines and 2,1,3-benzothiadiazoles were designed, synthesized and evaluated for their potential use as “fluorescent flippers” in mechanosensitive membrane probes.

  9. Full Papers

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      Revisiting Aromaticity and Chemical Bonding of Fluorinated Benzene Derivatives

      Juan J. Torres-Vega, Alejandro Vásquez-Espinal, Dr. Lina Ruiz, Prof. María A. Fernández-Herrera, Prof. Luis Alvarez-Thon, Prof. Gabriel Merino and Prof. William Tiznado

      Article first published online: 4 FEB 2015 | DOI: 10.1002/open.201402110

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      Determining aromaticity: Here, we analyzed the electron delocalization in fluorinated benzene derivatives (C6H(6−n)Fn) in terms of the induced magnetic field, nucleus-independent chemical shift (NICS), and ring current strength (RCS). Fluorination was found to decrease the paratropic ring current through inductive effects and to decrease the diatropic ring current through resonance effects, and the balance between these two effects decreases aromaticity with increased fluorination.

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      Quantum Chemical Calculations and Experimental Validation of the Photoclick Reaction for Fluorescent Labeling of the 5’ cap of Eukaryotic mRNAs

      Dr. Daniela Stummer, Prof. Carmen Herrmann and Prof. Andrea Rentmeister

      Article first published online: 4 FEB 2015 | DOI: 10.1002/open.201402104

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      Clicking with mRNA! Bioorthogonal click reactions are powerful tools to specifically label biomolecules in living cells. This joint theoretical and experimental study shows that an N-allyl-modified 5’ cap found in mRNA can be reacted with tetrazoles in a photoclick reaction. The combination of enzymatic allylation and photoclick chemistry generates a turn-on fluorophore specifically at the 5’ cap found in eukaryotic mRNAs.

  10. Communications

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      Uniform Functionalization of High-Quality Graphene with Platinum Nanoparticles for Electrocatalytic Water Reduction

      Raffaello Mazzaro, Alessandro Boni, Dr. Giovanni Valenti, Prof. Massimo Marcaccio, Prof. Francesco Paolucci, Dr. Luca Ortolani, Dr. Vittorio Morandi, Prof. Paola Ceroni and Dr. Giacomo Bergamini

      Article first published online: 1 FEB 2015 | DOI: 10.1002/open.201402151

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      A composite material comprised of monodispersed platinum nanoparticles on high-quality graphene was synthesized using two different exfoliating techniques. The materials performance as a catalyst in the electrocatalytic production of hydrogen from water at neutral pH is subsequently evaluated. The material exhibited a remarkably high turnover frequency at zero overpotential (∼4600 h−1 at pH 6.8). The material has potential in the development of robust and scalable water-splitting devices.

  11. Thesis Treasury

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      Cationic Antimicrobial Peptides (AMPs): Thermodynamic Characterization of Peptide–Lipid Interactions and Biological Efficacy of Surface-Tethered Peptides

      Dr. Mojtaba Bagheri

      Article first published online: 1 FEB 2015 | DOI: 10.1002/open.201402149

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      Antimicrobial peptides (AMPs) were investigated both as novel antibiotics and as antimicrobial coatings for biomedical implants. The hydrophobicity, conformational constraint, and strong binding of cyclo-RRRWFW (c-WFW) to the O-antigen region of lipopolysaccharide (LPS) were identified as important features for potent anti-E. coli activity. Furthermore, tethered membrane-active AMPs with uniform distribution of cationic and hydrophobic amino acid residue were identified as good anti-biofilm agents.

  12. Full Papers

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      Influence of Polarity and Activation Energy in Microwave–Assisted Organic Synthesis (MAOS)

      Dr. Antonio M. Rodríguez, Dr. Pilar Prieto, Prof. Antonio de la Hoz, Prof. Ángel Díaz-Ortiz, D. Raúl Martín and Prof. José I. García

      Article first published online: 1 FEB 2015 | DOI: 10.1002/open.201402123

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      Mastering microwaves: This work sought to determine parameters that have decisive roles in microwave-assisted organic reactions (MAOS) and to develop a model, using computational chemistry, to predict the type of reactions that can be improved by using microwave irradiation. Parameters such as polarity, activation energy, and enthalpy were found to be important in the improvement of MAOS.

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      Nickel(II) Complexes Bearing 4-arylimino-1,2,3-trihydroacridines: Synthesis, Characterization, and Ethylene Oligomerization

      Shengdong Wang, Shizhen Du, Prof. Dr. Wenjuan Zhang, Prof. Dr. Sin Asuha and Prof. Dr. Wen-Hua Sun

      Article first published online: 23 JAN 2015 | DOI: 10.1002/open.201402113

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      Nickel-based catalysis: Nickel(II) complexes make up a new generation of olefin catalysts which are important for processes like ethylene polymerization. Novel 4-arylimino-1,2,3-trihydroacridylnickel(II) dihalide complexes were synthesized in a one-pot reaction and characterized. Upon activation with trimethylaluminium (TMA), all complexes exhibited good activity for ethylene oligomerization and products ranged from butene (C4) to hexadecene (C16).

  13. Thesis Treasury

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      Supported Sulfonic Acids: Solid Catalysts for Batch and Continuous-Flow Synthetic Processes

      Dr. Calogero G. Piscopo

      Article first published online: 16 JAN 2015 | DOI: 10.1002/open.201402148

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      Its easy being green! In this work, supported sulfonic acids were used as effective catalysts for different classes of reactions. They have the advantage of being cheap, safe, and easy to recycle. Reaction conditions are mild, have good atom economy, and work-up steps are very easy, satisfying essential parameters of the “green chemistry” philosophy. Application of these catalysts to continuous-flow processes resulted in a considerable improvement in efficiency.

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      Synthetic Studies of Alkaloids Containing Pyrrolidine and Piperidine Structural Motifs

      Dr. Chinmay Bhat

      Article first published online: 16 JAN 2015 | DOI: 10.1002/open.201402128

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      Avenues to asymmetric alkaloids! Various 2-substituted pyrrolidine and piperidine chiral bioactive natural products were synthesized using a ‘chiral pool’ method. l-proline and l-pipecolinic acids with one chiral center served as the best precursors for the synthesis of these alkaloids. Overall, 14 total synthetic and 11 formal synthetic approaches were developed.

  14. Full Papers

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      Site-Specific Radioiodination of HER2-Targeting Affibody Molecules using 4-Iodophenethylmaleimide Decreases Renal Uptake of Radioactivity

      Joanna Strand, Dr. Patrik Nordeman, Hadis Honarvar, Dr. Mohamed Altai, Dr. Anna Orlova, Prof. Dr. Mats Larhed and Prof. Dr. Vladimir Tolmachev

      Article first published online: 12 JAN 2015 | DOI: 10.1002/open.201402097

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      Reducing renal radioactivity! Affibody molecules are small scaffold-based affinity proteins with promising properties as probes for radionuclide-based molecular imaging. The use of the more lipophilic 125I-4-iodophenethylmaleimide (IPEM) instead of 125I-3-iodo-((4-hydroxyphenyl)ethyl)maleimide (IHPEM) for site-specific radioiodination of Affibody molecules leads to a twofold decrease in renal retention of radioactivity.

  15. Communications

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      Ferric Phosphate Hydroxide Microstructures Affect Their Magnetic Properties

      Dr. Junhong Zhao, Youjuan Zhang, Zhen Run, Pengwei Li, Qifei Guo and Prof. Huan Pang

      Article first published online: 12 JAN 2015 | DOI: 10.1002/open.201402112

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      Size and shape matter! Precise control of the morphology of functional mirco/nanomaterials could allow for the control of their performance. Fe4(OH)3(PO4)3 microcrystals of different morphologies were successfully prepared under hydrothermal conditions by changing the reaction time, temperature, or amount of hexadecyltrimethylammonium bromide (CTAB). More importantly, their magnetic properties were affected by their size and shape.

  16. Full Papers

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      Synthesis and Characterization of CeO2 Nanoparticles via Solution Combustion Method for Photocatalytic and Antibacterial Activity Studies

      Thammadihalli Nanjundaiah Ravishankar, Thippeswamy Ramakrishnappa, Ganganagappa Nagaraju and Hanumanaika Rajanaika

      Article first published online: 3 JAN 2015 | DOI: 10.1002/open.201402046

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      Nanoparticles for the environment: CeO2 nanoparticles are competent photocatalysts for environmental applications because of their strong redox ability, nontoxicity, stability, and low cost. We synthesized CeO2 nanoparticles using a solution combustion method. These show photocatalytic activity in the degradation of trypan blue (a typical pollutant dye), antibacterial activity against Pseudomonas aeruginosa, and detoxifying activity as shown in the reduction of CrVI to CrIII.

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      Synthesis and Characterization of Layered Double Hydroxides and Their Potential as Nonviral Gene Delivery Vehicles

      Blake Balcomb, Dr. Moganavelli Singh and Dr. Sooboo Singh

      Article first published online: 18 DEC 2014 | DOI: 10.1002/open.201402074

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      Nonviral gene delivery: Layered double hydroxides (LDHs) exhibit anion-exchange chemistry making them suitable carriers of DNA. Mg−Al, Mg−Fe, Zn−Al, and Zn−Fe compounds known to be LDHs were synthesized and found to bind DNA in varying degrees. Nuclease digestion studies revealed the LDHs afford partial protection to bound DNA. HEK293 cells were successfully transfected using the LDHs, and minimal toxicity was observed, showing their potential as viable alternatives to other nonviral gene delivery systems.

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      Assessment of the Full Compatibility of Copper(I)-Catalyzed Alkyne-Azide Cycloaddition and Oxime Click Reactions for bis-Labelling of Oligonucleotides

      Sandra Estalayo-Adriàn, Dr. Rémy Lartia, Albert Meyer, Dr. Jean-Jacques Vasseur, Dr. François Morvan and Prof. Eric Defrancq

      Article first published online: 10 DEC 2014 | DOI: 10.1002/open.201402099

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      All roads lead to Rome! A new procedure for the efficient bis-conjugation of oligonucleotides through successive oxime ligation (Click-O) and copper(I)-catalyzed alkyne–azide cycloaddition (Click-H) or vice-versa is reported starting from 5′-amino, 3′-diol-functionalized oligonucleotide as an easily accessible precursor. The Click-O followed by Click-H route was found to be more efficient for accessing the bis-labelled oligonucleotide than the reverse.

  17. Communications

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      Chemoselective Oxidation of Benzyl, Amino, and Propargyl Alcohols to Aldehydes and Ketones under Mild Reaction Conditions

      C. B. Rajashekar Reddy, Dr. Sabbasani Rajasekhara Reddy and Shivaji Naidu

      Article first published online: 10 DEC 2014 | DOI: 10.1002/open.201402082

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      Chemoselective alcohol oxidation! Catalytic oxidation reactions often suffer from low yields and selectivity. Here we develop a method using copper(I) catalysts to selectively oxidize a wide range of benzyl and propargyl alcohols to their corresponding aldehydes and ketones under mild reaction conditions and with excellent yields. This chemoselective catalytic oxidation scheme can tolerate even sensitive and oxidizable groups such as alkynes, amines, and phenols.

  18. Full Papers

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      A New Porphyrin for the Preparation of Functionalized Water-Soluble Gold Nanoparticles with Low Intrinsic Toxicity

      Dr. Oriol Penon, Tania Patiño, Prof. Lleonard Barrios, Prof. Carme Nogués, Prof. David B. Amabilino , Prof. Klaus Wurst and Prof. Lluïsa Pérez-García

      Article first published online: 1 DEC 2014 | DOI: 10.1002/open.201402092

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      The power of gold! A new thiolated dissymmetrical porphyrin was synthesized and consequently immobilized onto gold nanoparticles using the Brust–Schiffrin method. Thiolated polyethylene glycol was added to obtain water-soluble nanoparticles. The nanoparticles could be internalized by cells and were nontoxic. Tests on the ability of the functionalized gold nanoparticles to induce singlet oxygen production point to a promising nanosystem for photodynamic therapy.

  19. Communications

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      Regulating the Coordination State of a Heme Protein by a Designed Distal Hydrogen-Bonding Network

      Jun-Fang Du, Dr. Wei Li, Prof. Dr. Lianzhi Li, Prof. Dr. Ge-Bo Wen, Prof. Dr. Ying-Wu Lin and Prof. Dr. Xiangshi Tan

      Article first published online: 1 DEC 2014 | DOI: 10.1002/open.201402108

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      Fine-tuning heme proteins: Heme coordination state determines the functional diversity of heme proteins. We introduced distal glutamic acid (Glu29) and histidine (His43) residues in myoglobin and regulated the heme into a non-native bis-His coordination state with native ligands His64 and His93, resembling natural globins such as cytoglobin and neuroglobin. This new approach can be generally applied for fine-tuning the structure and function of heme proteins.

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      Regioisomer-Free C4h β-Tetrakis(tert-butyl)metallo-phthalocyanines: Regioselective Synthesis and Spectral Investigations

      Norihito Iida, Kenta Tanaka, Etsuko Tokunaga, Hiromi Takahashi and Prof. Norio Shibata

      Article first published online: 21 NOV 2014 | DOI: 10.1002/open.201402093

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      A solid case for regioselectivity! The C4h-selective synthesis of β-(tert-butyl)metallophthalocyanines by tetramerization of α-trialkylsilyl phthalonitriles with metal salts following acid-mediated desilylation is disclosed for the first time. Investigation of regioisomer-free zinc β-tetrakis(tert-butyl)phthalocyanine using spectroscopy showed that the C4h single isomer is distinct in the solid state to zinc β-tetrakis(tert-butyl)phthalocyanine obtained by a conventional method.

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      Efficient Photoelectrochemical Energy Conversion using Spinach Photosystem II (PSII) in Lipid Multilayer Films

      Yun Zhang, Nikki M. Magdaong, Min Shen, Prof. Harry A. Frank and Prof. James F. Rusling

      Article first published online: 21 NOV 2014 | DOI: 10.1002/open.201402080

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      Powered like Popeye! Spinach photosystem II (PSII) protein was used for the first time in lipid films to make a photoelectrochemical device. Photocurrents from PSII in a ∼2 μm biomimetic dimyristoyl-phosphatidylcholine (DMPC) film on a pyrolytic graphite (PG) anode were ∼20 μA cm−2 in 40 mW cm−2 light. When used in a photobiofuel cell with a platinum black mesh cathode, the PSII–DMPC photoanode gave an output voltage of 0.6 V and a maximum output power 14 μW cm−2.

  20. Full Papers

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      Halogen and Hydrogen Bonding Benzothiophene Diol Derivatives: A Study Using ab initio Calculations and X-Ray Crystal Structure Measurements

      Prof. Enzo Cadoni, Dr. Giulio Ferino, Dr. Patrizia Pitzanti, Dr. Francesco Secci, Dr. Claudia Fattuoni, Prof. Francesco Nicolò and Prof. Giuseppe Bruno

      Article first published online: 12 NOV 2014 | DOI: 10.1002/open.201402087

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      Halogen be thy bond: X-ray crystal structures and ab initio calculations reveal that bromo- (top) and iodobenzothiophene diols (bottom) can generate intermolecular interactions with π electrons and/or with oxygen atoms through halogen bonding.

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