Synthesis of 11C-labeled Sulfonyl Carbamates through a Multicomponent Reaction Employing Sulfonyl Azides, Alcohols, and [11C]CO
Marc Y. Stevens, Dr. Shiao Y. Chow, Dr. Sergio Estrada, Dr. Jonas Eriksson, Veronika Asplund, Dr. Anna Orlova, Bogdan Mitran, Dr. Gunnar Antoni, Dr. Mats Larhed, Dr. Ola Åberg and Dr. Luke R. Odell
Version of Record online: 5 OCT 2016 | DOI: 10.1002/open.201600091
F-Ang-tasti-11C! A new multicomponent method of preparation of 11C-labeled sulfonyl carbamates from sulfonyl azides, alcohols, and [11C]CO is described. The method can be used to label a series of substrates, including a non-peptide angiotensin II receptor subtype 2 agonist currently in clinical trials. This compound is evaluated in a cell-based prostate cancer assay, and biodistribution and positron emission tomography imaging studies are conducted in healthy rats.