Advanced Healthcare Materials

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Recently Published Articles

  1. Spatio-temporal Control of LbL Films for Biomedical Applications: From 2D to 3D

    Claire Monge, Jorge Almodóvar, Thomas Boudou and Catherine Picart

    Article first published online: 27 JAN 2015 | DOI: 10.1002/adhm.201400715

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    The layer-by-layer (LbL) technique allows the engineering of biofunctional surface coatings with tremendous potential for biomedical applications. In this Review, the aims are to highlight the recent progresses in the field of LbL films for biomedical applications and to discuss the various ways to control spatially and temporally the biochemical and mechanical properties of multilayers.

  2. Multimodality Imaging of Coiled-Coil Mediated Self-Assembly in a “Drug-Free” Therapeutic System

    Rui Zhang, Jiyuan Yang, Te-Wei Chu, Jonathan M. Hartley and Jindřich Kopeček

    Article first published online: 21 JAN 2015 | DOI: 10.1002/adhm.201400679

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    A coiled-coil-mediated macromolecular therapeutic is designed to specifically kill non-Hodgkin's lymphoma cells without the aid of a drug or toxin. Two complementary conjugates are consecutively administered and bound to lymphoma B cell surface, resulting in CD20 crosslinking, membrane reorganization, and ultimately cell apoptosis. Multiple fluorescent images demonstrate that two conjugates can recognize and assemble at cancer cell surface in vitro and in vivo.

  3. Traceable Self-Assembly of Laser-Triggered Cyanine-Based Micelle for Synergistic Therapeutic Effect

    Yuan-I Chen, Cheng-Liang Peng, Pei-Chi Lee, Ming-Hsien Tsai, Chun-Yen Lin, Ying-Hsia Shih, Min-Feng Wei, Tsai-Yueh Luo and Ming-Jium Shieh

    Article first published online: 21 JAN 2015 | DOI: 10.1002/adhm.201400729

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    Doxo@Cy-micelle based on the novel amphiphilic copolymer, methoxy poly­(ethylene glycol) (mPEG)-cyanine-poly(ε-caprolactone) (mPEG-Cy-PCL), is simultaneously used for tracking and NIRF image-guided drug delivery. The obtained Doxo@Cy-micelles exhibit the laser-triggered release of Doxo and an excellent synergistic effect for the combined phototherapy and chemotherapy of cancer.

  4. X-Ray Excited Luminescence Chemical Imaging of Bacterial Growth on Surfaces Implanted in Tissue

    Fenglin Wang, Yash Raval, Tzuen-Rong J. Tzeng and Jeffrey N. Anker

    Article first published online: 21 JAN 2015 | DOI: 10.1002/adhm.201400685

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    A pH sensor film is coupled with an X-ray excited scintillator light source in order to image the local acidosis on the sensor film surface during bacterial growth. High spatial resolution pH imaging is achieved through tissue by irradiating the film surface with a narrowly collimated X-ray beam and collecting the luminescence spectrum point-by-point as the sample is moved relative to the beam.

  5. Development of a Cellularly Degradable PEG Hydrogel to Promote Articular Cartilage Extracellular Matrix Deposition

    Balaji V. Sridhar, John L. Brock, Jason S. Silver, Jennifer L. Leight, Mark A. Randolph and Kristi S. Anseth

    Article first published online: 21 JAN 2015 | DOI: 10.1002/adhm.201400695

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    A cell-mediated degradable hydrogel based on peptide- and protein-functionalized poly(ethylene glycol) hydrogels is designed to allow local cell degradation in a manner that promotes wide-spread cartilage extracellular matrix production, which leads to constructs with improved mechanical properties over just 14 d. The approach exploits the synergistic effects of co-culture between mesenchymal stem cells and chondrocytes to facilitate degradation of an MMP-cleavable peptide sequence.