Advanced Healthcare Materials

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Recently Published Articles

  1. Gel Scaffolds of BMP-2-Binding Peptide Amphiphile Nanofibers for Spinal Arthrodesis

    Sungsoo S. Lee, Erin L. Hsu, Marco Mendoza, Jason Ghodasra, Michael S. Nickoli, Amruta Ashtekar, Mahesh Polavarapu, Jacob Babu, Rehan M. Riaz, Joseph D. Nicolas, David Nelson, Sohaib Z. Hashmi, Start R. Kaltz, Jeffrey S. Earhart, Bradley R. Merk, Jeff S. McKee, Shawn F. Bairstow, Ramille N. Shah, Wellington K. Hsu and Samuel I. Stupp

    Article first published online: 22 APR 2014 | DOI: 10.1002/adhm.201400129

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    Supramolecular nanofibers presenting BMP-2-binding epitopes on the surface exhibit superior spinal fusion rates in rats, effectively decreasing the therapeutic dose of BMP-2 by 10-fold. Importantly, the bioactive nanofibers elicit 42% fusion rate without the addition of exogenous BMP-2.

  2. Carbon Nanotube Composites as Multifunctional Substrates for In Situ Actuation of Differentiation of Human Neural Stem Cells

    John Landers, Jeffrey T. Turner, Greg Heden, Aaron L. Carlson, Neal K. Bennett, Prabhas V. Moghe and Alexander V. Neimark

    Article first published online: 22 APR 2014 | DOI: 10.1002/adhm.201400042

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    For the first time, single-walled carbon nanotube–polymer composites are shown to enhance human neural stem cell (NSC) differentiation with electrical stimulation. The substrates are electrically conductive, mechanically robust, and highly biocompatible with human NSC cultures. The substrate's fibrous topography mimicking the extracellular matrix enhances neuronal lineage expression and electro-conductivity provides means for controlled stimulation of neuronal maturation.

  3. A Platform for Controlled Dual-Drug Delivery to the Retina: Protective Effects against Light-Induced Retinal Damage in Rats

    Nobuhiro Nagai, Hirokazu Kaji, Hideyuki Onami, Yuki Katsukura, Yumi Ishikawa, Zhaleh Kashkouli Nezhad, Kaori Sampei, Satoru Iwata, Shuntaro Ito, Matsuhiko Nishizawa, Toru Nakazawa, Noriko Osumi, Yukihiko Mashima and Toshiaki Abe

    Article first published online: 19 APR 2014 | DOI: 10.1002/adhm.201400114

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    Controlled transscleral co-delivery of two drugs, edaravone (EDV) and unoprostone (UNO), using a platform that comprises a microfabricated reservoir, controlled-release cover, and drug formulations, which are made of photopolymerized poly(ethyleneglycol) dimethacrylates, shows synergistic retinal neuroprotection against light injury in rats when compared with single-drug-loaded devices. The device would offer a safer therapeutic method than intravitreal injections for retinal disease treatments.

  4. Small-Dose-Sensitive X-Ray Image Pixel with HgI2 Photoconductor and Amorphous Oxide Thin-Film Transistor

    Jae Chul Park, Pyo Jin Jeon, Jin Sung Kim and Seongil Im

    Article first published online: 19 APR 2014 | DOI: 10.1002/adhm.201400077

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    A new X-ray image sensor is demonstrated with oxide thin-film transistor backplane and HgI2 sensing material. It displays outstanding image quality under a low X-ray exposure and a low electric field. It is promising as a state-of-the-art device to realize highly resolved images at a low X-ray dose for a variety of medical X-ray imaging applications.

  5. Bioreducible Carboxymethyl Dextran Nanoparticles for Tumor-Targeted Drug Delivery

    Thavasyappan Thambi, Dong Gil You, Hwa Seung Han, V. G. Deepagan, Sang Min Jeon, Yung Doug Suh, Ki Young Choi, Kwangmeyung Kim, Ick Chan Kwon, Gi-Ra Yi, Jun Young Lee, Doo Sung Lee and Jae Hyung Park

    Article first published online: 17 APR 2014 | DOI: 10.1002/adhm.201300691

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    Bioreducible nanoparticles bearing the disulfide bond are developed for the site-specific delivery of poorly water-soluble anticancer drugs at the tumor microenvironment. The nanoparticles are composed of hydrophilic carboxymethyl dextran and hydrophobic bile acid with an intervening disulfide bond. The hydrophilic shells of nanoparticles allow their prolonged circulation in the bloodstream, whereas the bioreducible disulfide bonds trigger the drug release inside the tumor cells after internalization of nanoparticles.