Advanced Healthcare Materials
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Recently Published Articles
- Towards an Improved anti-HIV Activity of NRTI via Metal–Organic Frameworks Nanoparticles
Valentina Agostoni, Tamim Chalati, Patricia Horcajada, Hervé Willaime, Resmi Anand, Nicolas Semiramoth, Tarek Baati, Shaun Hall, Guillaume Maurin, Hélène Chacun, Kawthar Bouchemal, Charlotte Martineau, Francis Taulelle, Patrick Couvreur, Christine Rogez-Kreuz, Pascal Clayette, Sandra Monti, Christian Serre and Ruxandra Gref
Article first published online: 17 JUN 2013 | DOI: 10.1002/adhm.201200454
Important payloads of AZT-TP are adsorbed within the porous cages of Iron trimesate nanoparticles (MIL-100 nanoMOFs) by impregnation. The active triphosphorylated metabolites strongly interact with the nanoparticles matrix by P-O-Fe coordination and are efficiently delivered within HIV-infected human mononuclear cells, significantly inhibiting the viral replication.
- Aligned Chitosan-Polycaprolactone Polyblend Nanofibers Promote the Migration of Glioblastoma Cells
Forrest M. Kievit, Ashleigh Cooper, Soumen Jana, Matthew C. Leung, Kui Wang, Dennis Edmondson, David Wood, Jerry S. H. Lee, Richard G. Ellenbogen and Miqin Zhang
Article first published online: 17 JUN 2013 | DOI: 10.1002/adhm.201300092
Human glioblastoma cells cultured on various nanofiber topographies show marked differences in migratory behavior. Cells exhibits directional persistence on all aligned nanofiber of different diameters, but the migratory behavior is most similar to that in vivo on 400 nm fibers, which provides a unique in vitro culture substrate for development of therapies for treatment of glioblastoma multiforme.
- Engineering Polymeric Microparticles as Theranostic Carriers for Selective Delivery and Cancer Therapy
Khin Yin Win, Enyi Ye, Choon Peng Teng, Shan Jiang and Ming-Yong Han
Article first published online: 28 MAY 2013 | DOI: 10.1002/adhm.201300077
Multifunctional polymeric nano- and microparticles are engineered as theranostic carriers and their selective size-dependent cellular uptake is demonstrated. It is found that effective uptake and accumulation of nanoparticles occurs in both normal and cancer cells, whereas, that of microparticles occurs in cancer cells but not in normal cells, allowing cancer cells to be specifically targeted for local drug delivery.
- Micropatterning Hydrophobic Liquid on a Porous Polymer Surface for Long-Term Selective Cell-Repellency
Erica Ueda and Pavel A. Levkin
Article first published online: 28 MAY 2013 | DOI: 10.1002/adhm.201300073
A simple method to form precise micropatterns of hydrophobic liquids using porous hydrophilic–hydrophobic substrates is presented. The micropatterns of hydrophobic liquid exhibit long-term stability, excellent cell-repellency, no cytotoxicity, and are more efficient than conventional PEG or superhydrophobic surfaces in controlling eukaryotic cell adhesion.
- Functional Morphometric Analysis in Cellular Behaviors: Shape and Size Matter
Haiyang Yu, Kee Pah Lim, Sijing Xiong, Lay Poh Tan and Winston Shim
Article first published online: 27 MAY 2013 | DOI: 10.1002/adhm.201300053
This is the first comprehensive review on common methodologies in morphological characterization of cellular systems. In this review, the underlying principles, assumptions, and limitations of morphological characterizations are discussed. The significance, challenges, and implications of quantitative morphometric characterization of cell shapes and sizes in cellular function are highlighted.