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Recently Published Articles

  1. Gold Nanoparticles Doped with 199Au Atoms and Their Use for Targeted Cancer Imaging by SPECT

    Yongfeng Zhao, Bo Pang, Hannah Luehmann, Lisa Detering, Xuan Yang, Deborah Sultan, Scott Harpstrite, Vijay Sharma, Cathy S. Cutler, Younan Xia and Yongjian Liu

    Article first published online: 10 FEB 2016 | DOI: 10.1002/adhm.201500992

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    Radioactive Au nanoparticles doped with 199Au atoms are conjugated with D-Ala1-peptide T-amide to serve as a CCR5-targeted nanoprobe for the sensitive and specific detection of both triple negative breast cancer and its metastasis in a mouse model by single photon emission computed tomography.

  2. Modular Assembly Approach to Engineer Geometrically Precise Cardiovascular Tissue

    Benjamin W. Lee, Bohao Liu, Adam Pluchinsky, Nathan Kim, George Eng and Gordana Vunjak-Novakovic

    Article first published online: 10 FEB 2016 | DOI: 10.1002/adhm.201500956

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    This modular assembly approach to microfabricate functional cardiovascular tissue composites enables quantitative assessment of the effects of microarchitecture on cellular function. Cardiac and endothelial modules are micromolded separately, designed to direct cardiomyocyte alignment and anisotropic contraction or vascular network formation. Assembled cardiovascular tissue composites synchronously contract, facilitating the use of this tissue-engineering platform to study structure–function relationships in the heart.

  3. Mannosylation Allows for Synergic (CD44/C-Type Lectin) Uptake of Hyaluronic Acid Nanoparticles in Dendritic Cells, but Only upon Correct Ligand Presentation

    Arianna Gennari, Maria Pelliccia, Roberto Donno, Ian Kimber and Nicola Tirelli

    Article first published online: 10 FEB 2016 | DOI: 10.1002/adhm.201500941

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    Mannosylation allows for a higher and adjuvant-dependent uptake of hyaluronic acid nanoparticles, although the critical receptor of their internalization appears still to be CD44.

  4. Image-Reversal Soft Lithography: Fabrication of Ultrasensitive Biomolecular Detectors

    Tina Saberi Safaei, Jagotamoy Das, Sahar Sadat Mahshid, Peter M. Aldridge, Edward H. Sargent and Shana O. Kelley

    Article first published online: 10 FEB 2016 | DOI: 10.1002/adhm.201501025

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    Image-reversal soft lithography enables the straightforward fabrication of high-performance biosensors without requiringhigh-resolution photolitography.

  5. Biomaterial-Stabilized Soft Tissue Healing for Healing of Critical-Sized Bone Defects: the Masquelet Technique

    Magdalena Tarchala, Edward J. Harvey and Jake Barralet

    Article first published online: 8 FEB 2016 | DOI: 10.1002/adhm.201500793

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    The Masquelet technique is a two-step surgical procedure used to treat critical-sized bone defects. Although clinically effective, the physiology of healing is not well understood and much has yet to be elucidated and optimized. Multiple modifiable factors have been identified and implemented. This review looks at the factors crucial to the success of the Masquelet technique and how we can further optimize them in clinical practice.