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Recently Published Articles

  1. Tissue in Cube: In Vitro 3D Culturing Platform with Hybrid Gel Cubes for Multidirectional Observations

    Masaya Hagiwara, Tomohiro Kawahara and Rina Nobata

    Article first published online: 29 APR 2016 | DOI: 10.1002/adhm.201600167

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    An in vitro 3D culturing platform enabling multidirectional observations of 3D biosamples is presented. The 3D structure of biosamples can be recognized without fluorescence. The cubic platform employs two types of hydrogels that are compatible with conventional culture dishes or well plates, facilitating growth in culture, ease of handling, and viewing at multiple angles.

  2. Multifunctional Polymeric Nanosystems for Dual-Targeted Combinatorial Chemo/Angiogenesis Therapy of Tumors

    Fatima Zohra Dahmani, Yan Xiao, Juan Zhang, Yao Yu, Jianping Zhou and Jing Yao

    Article first published online: 29 APR 2016 | DOI: 10.1002/adhm.201600169

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    A self-assembling nanosystem comprising of LMWH, gambogic acid, and c(RGDyK) peptide is developed for targeted chemo/antiangiogenesis combination therapy. This nanoassembly exhibiting both cytotoxic and antiangiogenic effects along with a dual targeting capability to tumor cells and angiogenic endothelium is shown to substantially improve the therapeutic efficacy of delivered drugs with reduced side-toxicity.

  3. Direct Mechanical Stimulation of Stem Cells: A Beating Electromechanically Active Scaffold for Cardiac Tissue Engineering

    Amy Gelmi, Artur Cieslar-Pobuda, Ebo de Muinck, Marek Los, Mehrdad Rafat and Edwin W. H. Jager

    Article first published online: 29 APR 2016 | DOI: 10.1002/adhm.201600307

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    Here a new type of smart cardiac patch material, the electromechanically active fiber scaffold, is presented. The scaffold is capable of delivering electrical and mechanical stimulation to individual cells and demonstrates controlled volume change actuation. The scaffold is noncytotoxic and may enhance the cardiac differentiation of human induced pluripotent stem cells.

  4. 3D Bioprinting Using a Templated Porous Bioink

    James P. K. Armstrong, Madeline Burke, Benjamin M. Carter, Sean A. Davis and Adam W. Perriman

    Article first published online: 29 APR 2016 | DOI: 10.1002/adhm.201600022

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    3D tissue printing with adult stem cells is reported. A novel cell-containing multicomponent bioink is used in a two-step 3D printing process to engineer bone and cartilage architectures.

  5. Surface-Driven Collagen Self-Assembly Affects Early Osteogenic Stem Cell Signaling

    Tojo Razafiarison, Unai Silván, Daniela Meier and Jess G. Snedeker

    Article first published online: 29 APR 2016 | DOI: 10.1002/adhm.201600128

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    The role of supramolecular ligand assembly on silicone substrates as a potential significant regulator of human bone marrow stromal cell adhesion and differentiation is investigated. A smooth collagen topography obtained on hydrophilic silicone tends to accelerate the onset of osteogenic differentiation when compared to the rough collagen layer on pristine hydrophobic silicone.