Advanced Healthcare Materials
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Recently Published Articles
- Compositions Including Synthetic and Natural Blends for Integration and Structural Integrity: Engineered for Different Vascular Graft Applications
Mozhgan Shojaee and Chris A. Bashur
Version of Record online: 29 MAR 2017 | DOI: 10.1002/adhm.201700001
Blends of synthetic and naturally-derived materials can overcome the engineered vascular graft challenges of stenosis and dilation by providing improved cellular remodeling and more time for remodeling. Other discussions include the impact of processing on crystallinity and component distribution, importance of considering the specific application when designing vascular grafts, and strategies to promote endothelialization for arteries with diameters <4 mm.
- Advanced Materials for Health Monitoring with Skin-Based Wearable Devices
Han Jin, Yasmin Shibli Abu-Raya and Hossam Haick
Version of Record online: 29 MAR 2017 | DOI: 10.1002/adhm.201700024
Concepts and approaches in skin-based wearable device that can serve for health monitoring and diagnosing disease, with an emphasis on emerging materials and fabrication techniques in the relevant fields, are reviewed and discussed.
- Control of Cell Alignment and Morphology by Redesigning ECM-Mimetic Nanotopography on Multilayer Membranes
Maria P. Sousa, Sofia G. Caridade and João F. Mano
Version of Record online: 29 MAR 2017 | DOI: 10.1002/adhm.201601462
Flexible and freestanding biomimetic multilayer membranes, which topography resemble the nanofeatures of the extracellular matrix, are successfully developed using a friendly user layer-by-layer technology. The ability to crosslink with genipin as well as the presence of a patterned topography on the surface of the natural-based membranes provides a promising system to tailor cellular behavior including cell alignment and differentiation.
- An Engineered Cell-Instructive Stroma for the Fabrication of a Novel Full Thickness Human Cervix Equivalent In Vitro
Vincenza De Gregorio, Giorgia Imparato, Francesco Urciuolo, Maria L. Tornesello, Clorinda Annunziata, Franco M. Buonaguro and Paolo A. Netti
Version of Record online: 29 MAR 2017 | DOI: 10.1002/adhm.201601199
In this work a bottom-up tissue engineering strategy is developed to obtain an engineered cell-instructive stroma by using human cervical microtissue precursors as functional building units. Starting from such 3D cervical stromal equivalent, a novel full thickness human cervical equivalent has been realized capable of expressing fundamental in vivo like functional characteristics.
- Versatile Polymer Nanoparticles as Two-Photon-Triggered Photosensitizers for Simultaneous Cellular, Deep-Tissue Imaging, and Photodynamic Therapy
Liang Guo, Jiechao Ge, Qian Liu, Qingyan Jia, Hongyan Zhang, Weimin Liu, Guangle Niu, Sha Liu, Jianru Gong, Steffen Hackbarth and Pengfei Wang
Version of Record online: 24 MAR 2017 | DOI: 10.1002/adhm.201601431
Multimodal polymer nanoparticles are developed for the first time as both two-photon fluorescence imaging and two-photon-excited photodynamic therapy (PDT) agent due to its strong two-photon-induced fluorescence, efficient 1O2 generation, high tissue penetration capability up to 2100 µm in mock tissue, and specific accumulation in lysosomes of HeLa cells.