Advanced Healthcare Materials

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Recently Published Articles

  1. A Multistep Photothermic-Driven Drug Release System Using Wire-Framed Au Nanobundles

    Doyeon Bang, Taeksu Lee, Jihye Choi, Yeonji Park, Eunkyoung Kim, Yong-Min Huh and Seungjoo Haam

    Article first published online: 19 JUL 2014 | DOI: 10.1002/adhm.201400197

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    Wire-framed Au nanobundles (WNBs) are synthesized for an externally controlled multistep drug release system. WNB consists of randomly oriented and mutually connected Au wires to form a bundle shape. In contrast to conventional nanoparticles that encapsulate a drug on their surface, WNBs preserve the drug payload in the overall inner volume, which provides a drug loading capacity sufficient for cancer therapy.

  2. The Bioactivity of Cartilage Extracellular Matrix in Articular Cartilage Regeneration

    Amanda J. Sutherland, Gabriel L. Converse, Richard A. Hopkins and Michael S. Detamore

    Article first published online: 17 JUL 2014 | DOI: 10.1002/adhm.201400165

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    Cartilage matrix as a biomaterial is a particularly promising material for enhanced cartilage regeneration because of the material's ability to provide stem cells with physical attachment sites, mechanical signals, and chemical signals. Cartilage matrix can be derived from both in vitro and tissue sources. Processing methods also differ as the matrix can be either chemically decellularized or physically devitalized.

  3. Directing Stem Cell Differentiation by Changing the Molecular Mobility of Supramolecular Surfaces

    Ji-Hun Seo, Sachiro Kakinoki, Tetsuji Yamaoka and Nobuhiko Yui

    Article first published online: 10 JUL 2014 | DOI: 10.1002/adhm.201400173

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    The polymer surfaces with a wide range of hydrated surface mobility are developed by a simple deposition method with supramolecular block copolymers. The morphologies of adhering stem cells are greatly dependent on the surface mobility of polymers, and this induces significant changes in the cytoskeletal signaling pathway to direct the downstream stem cell differentiation.

  4. You have free access to this content
    Tissue Engineering: Graphene-Based Patterning and Differentiation of C2C12 Myoblasts (Adv. Healthcare Mater. 7/2014) (page 949)

    Piyush Bajaj, Jose A. Rivera, Daniel Marchwiany, Vita Solovyeva and Rashid Bashir

    Article first published online: 10 JUL 2014 | DOI: 10.1002/adhm.201470033

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    P. Bajaj, R. Bashir, and co-workers use graphene as a biomaterial for muscle tissue engineering. On page 995 enhanced differentiation and spontaneous alignment of myotubes is observed in accordance with the underlying lithographically patterned graphene substrate. In addition, graphene also leads to the functional maturity of C2C12 myotubes. Cover image created by Janet Sinn-Hanlon, DesignGroup@VetMed, University of Illinois-Urbana Champaign.

  5. Contents: (Adv. Healthcare Mater. 7/2014) (pages 951–956)

    Article first published online: 10 JUL 2014 | DOI: 10.1002/adhm.201470035