Advanced Healthcare Materials

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Recently Published Articles

  1. Inhibition of Angiogenesis by Antioxidant Micelles

    Masaki Moriyama, Stéphanie Metzger, André J. van der Vlies, Hiroshi Uyama, Martin Ehrbar and Urara Hasegawa

    Article first published online: 11 SEP 2014 | DOI: 10.1002/adhm.201400249

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    Antioxidant micelles having catechol moieties in the core efficiently inhibit angiogenesis by scavenging reactive oxygen species as shown in the human umbilical vein endothelial cells (HUVECs) tube formation and ex ovo chicken chorioallantoic membrane (CAM) assay. These micelles may be useful in anti-angiogenic therapy to treat various diseases such as cancer.

  2. Elongation of Fibers from Highly Viscous Dextran Solutions Enables Fabrication of Rapidly Dissolving Drug Carrying Fabrics

    John P. Frampton, David Lai, Maxwell Lounds, Kyeongwoon Chung, Jinsang Kim, John F. Mansfield and Shuichi Takayama

    Article first published online: 10 SEP 2014 | DOI: 10.1002/adhm.201400287

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    A new method for creating fabrics composed entirely of dextran shows promise for use as a topical drug delivery system for antibiotics and hemostatic agents. This method uses the cohesive and adhesive forces of a highly viscous dextran solution to elongate fibers of approximately 10 μm in diameter between two substrates.

  3. Masthead: (Adv. Healthcare Mater. 9/2014)

    Article first published online: 8 SEP 2014 | DOI: 10.1002/adhm.201470046

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    Stem Cells: Reconstituting Vascular Microenvironment of Neural Stem Cell Niche in Three-Dimensional Extracellular Matrix (Adv. Healthcare Mater. 9/2014) (page 1349)

    Yoojin Shin, Kisuk Yang, Sewoon Han, Hyun-Ji Park, Yun Seok Heo, Seung-Woo Cho and Seok Chung

    Article first published online: 8 SEP 2014 | DOI: 10.1002/adhm.201470043

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    On page 1457 S.-W. Cho, S. Chung, and co-workers show that neural stem cell (NSC)-vascular niche consisting of a brain vasculature and 3D extracellular matrix (ECM) is reconstituted in a microfluidic system. The in vivo-like microenvironment reconstituted in this system allows NSCs to adopt physiologically relevant phenotypes through the combined effects of 3D ECM and vasculature.

  5. Biomimetic Materials: Peptide-Directed Spatial Organization of Biomolecules in Dynamic Gradient Scaffolds (Adv. Healthcare Mater. 9/2014) (page 1350)

    Lesley W. Chow, Astrid Armgarth, Jean-Philippe St-Pierre, Sergio Bertazzo, Cristina Gentilini, Claudia Aurisicchio, Seth D. McCullen, Joseph A. M. Steele and Molly M. Stevens

    Article first published online: 8 SEP 2014 | DOI: 10.1002/adhm.201470044

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    Peptide-polymer conjugates that specifically and dynamically bind glycosaminoglycans are used to functionalize the surface of biodegradable electrospun fiber scaffolds. The versatile platform presented by L. W. Chow, M. M. Stevens, and colleagues on page 1381 can be used to recreate gradients of ECM-like biomolecule organization within scaffolds to achieve more functional and clinically relevant tissue-engineered constructs.

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