Advanced Healthcare Materials

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Recently Published Articles

  1. Flavonoid-Modified Surfaces: Multifunctional Bioactive Biomaterials with Osteopromotive, Anti-Inflammatory, and Anti-Fibrotic Potential

    Alba Córdoba, María Satué, Manuel Gómez-Florit, Margarita Hierro-Oliva, Christiane Petzold, Staale P. Lyngstadaas, María Luisa González-Martín, Marta Monjo and Joana M. Ramis

    Article first published online: 21 OCT 2014 | DOI: 10.1002/adhm.201400587

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    Bioactive Ti surfaces functionalized with flavonoids taxifolin and quercitrin are successfully fabricated. These innovative, simple, cheap, and robust surfaces exhibit osteogenic, osteopromotive, anti-inflammatory, and anti-fibrotic properties with promising applications in implantable bone medical devices. Given the broad range of functionalities of flavonoid compounds (antioxidant, antibacterial, antiviral, etc.), these surfaces could be extended to other biomedical applications.

  2. Plasmonic Nanodiamonds: Targeted Core–Shell Type Nanoparticles for Cancer Cell Thermoablation

    Ivan Rehor, Karin L. Lee, Kevin Chen, Miroslav Hajek, Jan Havlik, Jana Lokajova, Milan Masat, Jitka Slegerova, Sourabh Shukla, Hamed Heidari, Sara Bals, Nicole F. Steinmetz and Petr Cigler

    Article first published online: 21 OCT 2014 | DOI: 10.1002/adhm.201400421

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    Plasmonic nanodiamonds bearing a thin gold shell are prepared, biocom­patibilized, and functionalized with alkyne groups. Azide-modified transferrin is attached providing particles with high colloidal stability. These nontoxic particles target efficiently cancer cells overexpressing the transferrin receptor and enable quantitative ablation of the cancer cells with a short, one-minute irradiation by a pulse near-infrared laser.

  3. CpG-Loaded Multifunctional Cationic Nanohydrogel Particles as Self-Adjuvanting Glycopeptide Antitumor Vaccines

    Sebastian Hartmann, Lutz Nuhn, Björn Palitzsch, Markus Glaffig, Natascha Stergiou, Bastian Gerlitzki, Edgar Schmitt, Horst Kunz and Rudolf Zentel

    Article first published online: 18 OCT 2014 | DOI: 10.1002/adhm.201400460

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    Self-adjuvanting antitumor vaccines by multifunctional cationic ­nanohydrogels loaded with CpG. A conjugate ­consisting of tumor-associated MUC1-glycopeptide B-cell epitope and tetanus toxin ­T-cell epitope P2 was linked to cationic nanogels. Oligonucleotide CpG complexation enhanced toll-like receptor (TLR) stimulated T-cell proliferation and rapid immune activation. This co-delivery promotes induction of specific MUC1-antibodies binding to human breast ­tumor cells without external adjuvant.

  4. Spheroform: Therapeutic Spheroid-Forming Nanotextured Surfaces Inspired by Desert Beetle Physosterna cribripes

    Mihyun Lee, Kisuk Yang, Yong Hwa Hwang, Youngro Byun, Dong Yun Lee, Seung-Woo Cho and Haeshin Lee

    Article first published online: 17 OCT 2014 | DOI: 10.1002/adhm.201400429

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    An approach is presented to create arrays of quasi-spherical microdroplets by surfaces called “spheroform” inspired by micro-/nanostructures found in the back of the Namib desert beetle. Spheroform is fabricated by microarray formation of catecholamine polymers on the superhydrophobic background. Spheroform is able to precisely control spheroid sizes of therapeutic islet cells and mesenchymal stem cells. The therapeutic spheroids exhibits improved biochemical activities.

  5. Injectable Silk Foams for Soft Tissue Regeneration

    Evangelia Bellas, Tim J. Lo, Eric P. Fournier, Joseph E. Brown, Rosalyn D. Abbott, Eun S. Gil, Kacey G. Marra, J. Peter Rubin, Gary G. Leisk and David L. Kaplan

    Article first published online: 16 OCT 2014 | DOI: 10.1002/adhm.201400506

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    An injectable solid state silk foam is designed for minimally invasive soft tissue regeneration applications. These silk foams can deform to be injected and retain their original dimensions after injection. Foams support stem cell survival in vitro and support tissue ingrowth for at least 3 months in vivo.