Advanced Healthcare Materials
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Recently Published Articles
- Review of the Development of Methods for Characterization of Microspheres for Use in Embolotherapy: Translating Bench to Cathlab
Marcus Caine, Dario Carugo, Xunli Zhang, Martyn Hill, Matthew R. Dreher and Andrew L. Lewis
Version of Record online: 20 FEB 2017 | DOI: 10.1002/adhm.201601291
Particulate embolization is used to block blood vessels, particularly within hypervascularized tumors, as they are available in calibrated sizes and can be delivered distally via microcatheters for precise occlusion with optional locoregional drug delivery. The current progress in development of bespoke techniques incorporating physical handling, fluid dynamics, occlusive behavior, and sustained drug elution kinetics within vascular systems is reviewed.
- Long-Term Tissue Culture of Adult Brain and Spleen Slices on Nanostructured Scaffolds
Sonja Kallendrusch, Felicitas Merz, Ingo Bechmann, Stefan G. Mayr and Mareike Zink
Version of Record online: 20 FEB 2017 | DOI: 10.1002/adhm.201601336
Organotypic tissue culture of adult rodent brain and spleen slices is demonstrated on TiO2 nanotube scaffolds for 5 and 14 days. In contrast to often employed polytetrafluoroethylene (PTFE) membranes, nanotube scaffolds support tissue adhesion and good medium supply due to their nanogeometry. In fact, for different tissues, the nanotube structure must be adapted to support cell survival and tissue integrity.
- Electrical Differentiation of Mesenchymal Stem Cells into Schwann-Cell-Like Phenotypes Using Inkjet-Printed Graphene Circuits
Suprem R. Das, Metin Uz, Shaowei Ding, Matthew T. Lentner, John A. Hondred, Allison A. Cargill, Donald S. Sakaguchi, Surya Mallapragada and Jonathan C. Claussen
Version of Record online: 20 FEB 2017 | DOI: 10.1002/adhm.201601087
Inkjet-printed graphene circuits induce mesenchymal stem cell differentiation into Schwann cells via solely electrical stimulation. Fluorescent immunolabeling and paracrine activity measurements reveal higher levels of differentiation for cells grown on and electrical stimulated by the graphene circuits versus conventional chemical methods. These results are a step toward the creation of implantable neural network circuits for in vivo stem cell differentiation for neuroregeneration.
- Radiolabelled Polymeric Materials for Imaging and Treatment of Cancer: Quo Vadis?
Kritee Pant, Ondřej Sedláček, Robin A. Nadar, Martin Hrubý and Holger Stephan
Version of Record online: 20 FEB 2017 | DOI: 10.1002/adhm.201601115
In this review the historical progress as well as recent advances of radiolabelled natural and synthetic polymers applied in cancer imaging and treatment, including drug delivery systems, are highlighted. Advantages and disadvantages of different radiolabelling as well as targeting strategies are discussed.
- Bisphosphonate-Functionalized Imaging Agents, Anti-Tumor Agents and Nanocarriers for Treatment of Bone Cancer
Robin A. Nadar, Nicola Margiotta, Michele Iafisco, Jeroen J. J. P. van den Beucken, Otto C. Boerman and Sander C. G. Leeuwenburgh
Version of Record online: 16 FEB 2017 | DOI: 10.1002/adhm.201601119
Novel bisphosphonate-functionalized imaging and therapeutic agents as well as nanocarriers are being developed for treatment of bone cancer. This review provides an update on the preclinical efficacy of bisphosphonate-functionalized fluorophores, anti-tumor agents and nanocarriers for the treatment of bone metastases.