Advanced Healthcare Materials

Cover image for Vol. 6 Issue 21

Editor-in-Chief: Lorna Stimson; Deputy Editors: Uta Goebel, Emily Hu

Online ISSN: 2192-2659

Associated Title(s): Advanced Biosystems, Advanced Functional Materials, Advanced Materials, Advanced Materials Technologies, Advanced Science, Biotechnology Journal, Macromolecular Bioscience, Small

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Recently Published Articles

  1. pH/Ultrasound Dual-Responsive Gas Generator for Ultrasound Imaging-Guided Therapeutic Inertial Cavitation and Sonodynamic Therapy

    Qianhua Feng, Wanxia Zhang, Xuemei Yang, Yuzhen Li, Yongwei Hao, Hongling Zhang, Lin Hou and Zhenzhong Zhang

    Version of Record online: 15 NOV 2017 | DOI: 10.1002/adhm.201700957

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    The sonosensitizer loaded mesoporous calcium carbonate nanoparticles decompose instantaneously under the cotriggering of tumoral inherent acidic condition and ultrasound irradiation. The released CO2 and sonosensitizer exploited the merits of synergistic combination of therapeutic inertial cavitation and sonodynamic therapy simultaneously, resulting in antitumor effects with multimechanisms.

  2. Placental Drug Transport-on-a-Chip: A Microengineered In Vitro Model of Transporter-Mediated Drug Efflux in the Human Placental Barrier

    Cassidy Blundell, Yoon-Suk Yi, Lin Ma, Emily R. Tess, Megan J. Farrell, Andrei Georgescu, Lauren M. Aleksunes and Dongeun Huh

    Version of Record online: 9 NOV 2017 | DOI: 10.1002/adhm.201700786

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    This paper presents a microengineered model of the human placental barrier for investigation of maternal–fetal drug transfer in pregnancy. The placenta-on-a-chip system reconstitutes efflux transporter-mediated transport of a test compound, demonstrating proof-of-principle for use as a screening platform for prediction of drug transport in pregnancy.

  3. 3D Maskless Micropatterning for Regeneration of Highly Organized Tubular Tissues

    Chi Ma, Tiejun Qu, Bei Chang, Yan Jing, Jerry Q. Feng and Xiaohua Liu

    Version of Record online: 9 NOV 2017 | DOI: 10.1002/adhm.201700738

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    A unique maskless micropatterning technology is developed to create 3D nanofibrous matrices with highly organized tubular architecture for tissue regeneration. The tubular architecture presents crucial biophysical cues to dental pulp stem cell migration, polarization, and differentiation. When using this 3D tubular hierarchical matrix as a scaffold, functional tubular dentin is successfully regenerated with the same well-organized microstructure as its natural counterpart.

  4. Preventing Obstructions of Nanosized Drug Delivery Systems by the Extracellular Matrix

    Luise Tomasetti and Miriam Breunig

    Version of Record online: 9 NOV 2017 | DOI: 10.1002/adhm.201700739

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    Nanoparticle obstruction by the extracellular matrix endangers therapeutic success. Mobility is restricted by the small pores of the matrix and by electrostatic interactions with the network. Only particle diameters that do not exceed the pore sizes of the matrix (Rd/p < 1) and that have neutral or negative surface charge can pass the barrier. Larger or positively charged particles are trapped.

  5. Progress Toward the Clinical Translation of Bioinspired Peptide and Protein Assemblies

    Kelly M. Hainline, Chelsea N. Fries and Joel H. Collier

    Version of Record online: 8 NOV 2017 | DOI: 10.1002/adhm.201700930

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    Supramolecular peptide biomaterials are being advanced toward clinical applications. This progress report describes self-assembled polypeptide biomaterials that have been translated into clinical applications, along with those making steady progress toward patients. Although the majority of new supramolecular polypeptide materials have yet to be translated, the regulatory approval and commercialization of several examples is encouraging for the field.