Advanced Healthcare Materials

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Recently Published Articles

  1. Molecularly Engineered Self-Assembling Membranes for Cell-Mediated Degradation

    Daniela S. Ferreira, Yi-An Lin, Honggang Cui, Jeffrey A. Hubbell, Rui L. Reis and Helena S. Azevedo

    Article first published online: 21 NOV 2014 | DOI: 10.1002/adhm.201400586

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    Self-assembling membranes, molecularly designed with enzyme-cleavable building blocks (hyaluronan and peptide amphiphiles containing a proteolytic domain) afford cell-mediated degradation and lead to enhanced cellular colonization of the membranes. This concept can be used as a strategy to develop artificial matrices with more biomimetic degradation for tissue engineering applications.

  2. Antimicrobial Polymers

    Anjali Jain, L. Sailaja Duvvuri, Shady Farah, Nurit Beyth, Abraham J. Domb and Wahid Khan

    Article first published online: 19 NOV 2014 | DOI: 10.1002/adhm.201400418

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    Antimicrobial polymers are the materials having the capability to kill/inhibit the growth of microbes on their surface or surrounding environment. Recently, they gained considerable interest for both research and industry applications. In this Review, an overview of different antimicrobial polymers, their mechanism of action, factors affecting antimicrobial activity and application in various fields are given.

  3. Organic Transdermal Iontophoresis Patch with Built-in Biofuel Cell

    Yudai Ogawa, Koichiro Kato, Takeo Miyake, Kuniaki Nagamine, Takuya Ofuji, Syuhei Yoshino and Matsuhiko Nishizawa

    Article first published online: 17 NOV 2014 | DOI: 10.1002/adhm.201400457

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    A completely organic iontophoresis patch is reported. A built-in biofuel cell is mounted on the patch that generates transdermal iontophoretic administration of compounds into the skin. The amplitude of transdermal current is tuned by integrating a conducting polymer-based stretchable resistor of predetermined resistance.

  4. Contact Lens Sensors in Ocular Diagnostics

    Nicholas M. Farandos, Ali K. Yetisen, Michael J. Monteiro, Christopher R. Lowe and Seok Hyun Yun

    Article first published online: 17 NOV 2014 | DOI: 10.1002/adhm.201400504

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    Contact lens sensors have been used as minimally invasive and continuous analytical devices to diagnose glaucoma by measuring intraocular pressure, and diabetes from lachrymal glucose. This Review covers contact lens sensors from concept to market by analyzing detection mechanisms, micro/nanofabrication, powering, readout techniques, and high-volume manufacturing, supplemented by a case study. A market analysis and FDA approval process are also outlined.

  5. Controlling the Dynamics of Cell Transition in Heterogeneous Cultures using Surface Chemistry

    Graham J. Hickman, Robert C. Rees, David J. Boocock, A. Graham Pockley and Carole C. Perry

    Article first published online: 13 NOV 2014 | DOI: 10.1002/adhm.201400525

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    An amino-functionalized tissue culture material, which promotes enrichment of an epithelial phenotype from a cancer cell line containing both epithelial and mesenchymal subpopulations, is described. Transitional events in culture between epithelial and mesenchymal phenotypes are implicated in metastasis, isolation, and transitional control of such subpopulations using functional materials will enhance our understanding of cancer cell growth, differentiation, and invasion.