Advanced Healthcare Materials

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Recently Published Articles

  1. Monocyte-Targeting Supramolecular Micellar Assemblies: A Molecular Diagnostic Tool for Atherosclerosis

    Eun Ji Chung, Laurie B. Mlinar, Kathryn Nord, Matthew J. Sugimoto, Emily Wonder, Francis J. Alenghat, Yun Fang and Matthew Tirrell

    Article first published online: 22 AUG 2014 | DOI: 10.1002/adhm.201400336

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    Monocyte-targeting, peptide amphiphile micelles are a promising new class of diagnostic agents for molecular imaging of atherosclerosis. In addition to discriminating and detecting the varying stages of atherosclerosis in vivo, these nanoparticles have the potential to be developed as theranostic systems for a variety of diseases where inflammation is the underlying cause.

  2. Nanoparticles Containing a Liver X Receptor Agonist Inhibit Inflammation and Atherosclerosis

    Xue-Qing Zhang, Orli Even-Or, Xiaoyang Xu, Mariska van Rosmalen, Lucas Lim, Suresh Gadde, Omid C. Farokhzad and Edward A. Fisher

    Article first published online: 22 AUG 2014 | DOI: 10.1002/adhm.201400337

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    The nuclear hormone receptor LXR has a number of properties that would be valuable in preventing or treating atherosclerosis, the underlying cause of heart attacks and stroke. Nanoparticles containing an activator of LXR are described and demonstrated to produce significant atherosclerosis benefits without stimulating liver lipid metabolism in a mouse model of atherosclerosis.

  3. Biocompatible Reactive Oxygen Species (ROS)-Responsive Nanoparticles as Superior Drug Delivery Vehicles

    Dinglin Zhang, Yanling Wei, Kai Chen, Xiangjun Zhang, Xiaoqiu Xu, Qing Shi, Songling Han, Xin Chen, Hao Gong, Xiaohui Li and Jianxiang Zhang

    Article first published online: 22 AUG 2014 | DOI: 10.1002/adhm.201400299

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    A novel reactive oxygen species (ROS)-responsive nanoplatform can be successfully manufactured from a ROS-triggerable β-cyclodextrin material. Extensive in vitro and in vivo studies validate that this nanoscaled system may serve as a new drug delivery vehicle with well-defined ROS-sensitivity and superior biocompatibility. This nanocarrier can be used for ROS-triggered transport of diverse therapeutics and imaging agents.

  4. Anisotropic Cellular Network Formation in Engineered Muscle Tissue through the Self-Organization of Neurons and Endothelial Cells

    Hironobu Takahashi, Tatsuya Shimizu, Masamichi Nakayama, Masayuki Yamato and Teruo Okano

    Article first published online: 21 AUG 2014 | DOI: 10.1002/adhm.201400297

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    Tissue anisotropy directed by cell sheets: Aligned myoblasts can be harvested as an anisotropic cell sheet using a micropatterned thermoresponsive substrate. Neurons and endothelial cells sandwiched between multiple anisotropic cell sheets self-organize oriented cellular networks in the tissue construct. This simple tissue engineering technique is useful for creation of biomimetic microstructures in complex tissue, required for future advances in regenerative medicine.