Advanced Healthcare Materials

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Recently Published Articles

  1. Polysaccharide-Coated PCL Nanofibers for Wound Dressing Applications

    Florence Croisier, Ganka Atanasova, Yves Poumay and Christine Jérôme

    Article first published online: 29 SEP 2014 | DOI: 10.1002/adhm.201400380

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    The preparation of multilayered polysaccharide-based nanofibers by combination of electrospinning and layer-by-layer deposition techniques is reported. The electrospinning of poly(ε-caprolactone) in presence of a block-copolymer bearing carboxylic acid functions leads to the elaboration of charged fibers. These fibers are then coated with polyelectrolytes—notably chitosan and hyaluronic acid poly­saccharides—using layer-by-layer deposition, to finally obtain multilayered fibers.

  2. Organic Electrochemical Transistors for Clinical Applications

    Pierre Leleux, Jonathan Rivnay, Thomas Lonjaret, Jean-Michel Badier, Christian Bénar, Thierry Hervé, Patrick Chauvel and George G. Malliaras

    Article first published online: 29 SEP 2014 | DOI: 10.1002/adhm.201400356

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    It is shown that organic electrochemical transistors are able to record cardiac rhythm, eye movement, and brain activity in humans. These devices, therefore, show promise as amplifying transducers for the recoding of electrophysiological signals of clinical relevance.

  3. Co-Delivery of Antiviral and Antifungal Therapeutics for the Treatment of Sexually Transmitted Infections using a Moldable, Supramolecular Hydrogel

    Ashlynn L.Z. Lee, Victor W.L. Ng, Ghim Lee Poon, Xiyu Ke, James L. Hedrick and Yi Yan Yang

    Article first published online: 18 SEP 2014 | DOI: 10.1002/adhm.201400340

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    A topically applied antiviral/antifungal hydrogel that can potentially enhance HIV prevention and simultaneously circumvent sexually transmitted infections (STIs) is presented. The entrapment of antiretroviral drug tenofovir within hydrogels enables an appreciably sustained release of the drug. Hydrogels loaded with antimicrobial polymers effectively eradicate the biomass and reduce the viability of microbes residing as Candida albicans biofilms.

  4. Tapered Microtract Array Platform for Antimigratory Drug Screening of Human Glioblastoma Multiforme

    Junghwa Cha, Ilkyoo Koh, Yemuk Choi, Jungwhoi Lee, Chulhee Choi and Pilnam Kim

    Article first published online: 17 SEP 2014 | DOI: 10.1002/adhm.201400384

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    Tapered microtract array platform (TMAP), which mimics the anatomical features of brain tissue, induces the native characteristics and behavior of glioma cells by topographic cues. The glioma cells on the TMAP exhibit remarkable phenotype transition (crawling-to-saltatory migration). By simply varying the topographic cues, the TMAP can be employed to efficiently screen anti-cancer drug of human brain tumor cells.

  5. Inhibition of Angiogenesis by Antioxidant Micelles

    Masaki Moriyama, Stéphanie Metzger, André J. van der Vlies, Hiroshi Uyama, Martin Ehrbar and Urara Hasegawa

    Article first published online: 11 SEP 2014 | DOI: 10.1002/adhm.201400249

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    Antioxidant micelles having catechol moieties in the core efficiently inhibit angiogenesis by scavenging reactive oxygen species as shown in the human umbilical vein endothelial cells (HUVECs) tube formation and ex ovo chicken chorioallantoic membrane (CAM) assay. These micelles may be useful in anti-angiogenic therapy to treat various diseases such as cancer.