Advanced Healthcare Materials

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Recently Published Articles

  1. A Polyphenylene Dendrimer Drug Transporter with Precisely Positioned Amphiphilic Surface Patches

    René Stangenberg, Yuzhou Wu, Jana Hedrich, Dennis Kurzbach, Daniel Wehner, Gilbert Weidinger, Seah Ling Kuan, Malin Insa Jansen, Fedor Jelezko, Heiko J. Luhmann, Dariush Hinderberger, Tanja Weil and Klaus Müllen

    Article first published online: 2 SEP 2014 | DOI: 10.1002/adhm.201400291

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    A universal platform for designing a drug transporter that mimics many features of proteins is achieved by the precise positioning of hydrophilic and hydrophobic groups at the periphery of the semirigid polyphenylene dendrimer scaffolds. The thus-derived, highly refined architectures with tunable lipophilic pockets allow drug transport that can even penetrate the blood–brain barrier and exhibit no toxicity in zebrafish embryos.

  2. A Compressible Scaffold for Minimally Invasive Delivery Of Large Intact Neuronal Networks

    Amélie Béduer, Thomas Braschler, Oliver Peric, Georg E. Fantner, Sébastien Mosser, Patrick C. Fraering, Sidi Benchérif, David J. Mooney and Philippe Renaud

    Article first published online: 1 SEP 2014 | DOI: 10.1002/adhm.201400250

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    Centimeter-sized injectable neural scaffolds based on macroporous cryogels are presented. They can be injected through a syringe needle, while conserving neuron viability, neurite organization, and scaffold integrity. The system is an answer to a major dilemma in neural tissue engineering for the central nervous system: large preorganized scaffolds that should be delivered in minimally invasive fashion to avoid further tissue damage.

  3. Modified Poly(lactic-co-glycolic Acid) Nanoparticles for Enhanced Cellular Uptake and Gene Editing in the Lung

    Rachel J. Fields, Elias Quijano, Nicole Ali McNeer, Christina Caputo, Raman Bahal, Kavi Anandalingam, Marie E. Egan, Peter M. Glazer and W. Mark Saltzman

    Article first published online: 25 AUG 2014 | DOI: 10.1002/adhm.201400355

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    Surface-modified poly(lactic-co-glycolic acid) (PLGA)/poly(β-aminoester)(PBAE)nanoparticles(NPs) have shown great promisein gene delivery. In this work, the pulmonary cellular uptake of these NPs is evaluated and surface-modified PLGA/PBAE NPs are shown to achieve higher cellular association and gene editing than traditional NPs composed of PLGA or PLGA/PBAE blends alone.

  4. Monocyte-Targeting Supramolecular Micellar Assemblies: A Molecular Diagnostic Tool for Atherosclerosis

    Eun Ji Chung, Laurie B. Mlinar, Kathryn Nord, Matthew J. Sugimoto, Emily Wonder, Francis J. Alenghat, Yun Fang and Matthew Tirrell

    Article first published online: 22 AUG 2014 | DOI: 10.1002/adhm.201400336

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    Monocyte-targeting, peptide amphiphile micelles are a promising new class of diagnostic agents for molecular imaging of atherosclerosis. In addition to discriminating and detecting the varying stages of atherosclerosis in vivo, these nanoparticles have the potential to be developed as theranostic systems for a variety of diseases where inflammation is the underlying cause.

  5. Nanoparticles Containing a Liver X Receptor Agonist Inhibit Inflammation and Atherosclerosis

    Xue-Qing Zhang, Orli Even-Or, Xiaoyang Xu, Mariska van Rosmalen, Lucas Lim, Suresh Gadde, Omid C. Farokhzad and Edward A. Fisher

    Article first published online: 22 AUG 2014 | DOI: 10.1002/adhm.201400337

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    The nuclear hormone receptor LXR has a number of properties that would be valuable in preventing or treating atherosclerosis, the underlying cause of heart attacks and stroke. Nanoparticles containing an activator of LXR are described and demonstrated to produce significant atherosclerosis benefits without stimulating liver lipid metabolism in a mouse model of atherosclerosis.