Advanced Healthcare Materials

Cover image for Vol. 6 Issue 18

Editor-in-Chief: Lorna Stimson; Deputy Editors: Uta Goebel, Emily Hu

Online ISSN: 2192-2659

Associated Title(s): Advanced Biosystems, Advanced Functional Materials, Advanced Materials, Advanced Materials Technologies, Advanced Science, Biotechnology Journal, Macromolecular Bioscience, Small

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Recently Published Articles

  1. Fabrication of Calcium Phosphate-Based Nanocomposites Incorporating DNA Origami, Gold Nanorods, and Anticancer Drugs for Biomedical Applications

    Hongbo Zhang, Xiangmeng Qu, Hong Chen, Haixin Kong, Ruihua Ding, Dong Chen, Xu Zhang, Hao Pei, Hélder A. Santos, Mingtan Hai and David A. Weitz

    Version of Record online: 22 SEP 2017 | DOI: 10.1002/adhm.201700664

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    A biocompatible photothermal and pH dual responsive nano-in-nanocomposite is developed to both protect DNA origami from degradation and facilitate loading of therapeutics. The DNA origami, gold nanorods, and anticancer drugs are co-incorporated into calcium phosphate nanoparticles coated with a thin layer of phospholipid. The nanocomposites synergistically induce cancer cell apoptosis and reduce the multidrug resistance for potential clinical and biomedical applications.

  2. The Influence of Hyaluronic Acid and Glioblastoma Cell Coculture on the Formation of Endothelial Cell Networks in Gelatin Hydrogels

    Mai T. Ngo and Brendan A. Harley

    Version of Record online: 22 SEP 2017 | DOI: 10.1002/adhm.201700687

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    The glioblastoma perivascular niche is incorporated into a gelatin hydrogel via coculture of endothelial, stromal, and glioblastoma cells. Endothelial network complexity can be manipulated through hydrogel stiffness and covalent immobilization of brain-mimetic hyaluronic acid and vascular endothelial growth factor into the hydrogel network. Glioblastoma cells associate closely with endothelial cell networks and promote processes similar to vessel co-option and regression seen in vivo.

  3. Co-Delivery of Drugs and Genes Using Polymeric Nanoparticles for Synergistic Cancer Therapeutic Effects

    Yi Li, Thavasyappan Thambi and Doo Sung Lee

    Version of Record online: 22 SEP 2017 | DOI: 10.1002/adhm.201700886

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    Polymeric nanoparticles-mediated combination therapy is an effective strategy in cancer treatment. Co-delivery of dual drugs or drug/gene can enhance anti-cancer efficacy due to a synergistic effect. Moreover, polymeric nanocarriers can improve biodistribution of the therapeutics as well as release them at target sites. In this Progress Report, recent progresses in preparation and application of polymeric drug and gene co-delivery nanosystems are summarized.

  4. Nanomaterials in the Prevention, Diagnosis, and Treatment of Mycobacterium Tuberculosis Infections

    Kaijin Xu, Zhen Chang Liang, Xin Ding, Haiyang Hu, Shaoqiong Liu, Martin Nurmik, Sheng Bi, Feishu Hu, Zhongkang Ji, Jingjing Ren, Shigui Yang, Yi Yan Yang and Lanjuan Li

    Version of Record online: 21 SEP 2017 | DOI: 10.1002/adhm.201700509

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    The use of nanomaterials in mycobacterium tuberculosis (TB) detection, treatment, and prevention has made significant progress in the past decade. This review discusses nanomaterials for rapid and accurate detection of TB pathogens, nanocarriers for enhancing anti-TB drug concentrations in target organs, and antigen nanocarriers as effective TB vaccine adjuvants.

  5. Coordination-Accelerated “Iron Extraction” Enables Fast Biodegradation of Mesoporous Silica-Based Hollow Nanoparticles

    Liying Wang, Minfeng Huo, Yu Chen and Jianlin Shi

    Version of Record online: 21 SEP 2017 | DOI: 10.1002/adhm.201700720

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    Coordination-accelerated biodegradation strategy: A chemical coordination-accelerated biodegradation strategy is illustrated to endow hollow mesoporous silica nanoparticles with proteinous coordination-responsive biodegradability (via “iron extraction”), on-demand coordination-responsive drug releasing behavior, and significantly enhanced chemotherapeutic efficacy by directly doping iron (Fe) ions into the framework of mesoporous silica.