Advanced Healthcare Materials

Cover image for Vol. 7 Issue 3

Editor-in-Chief: Lorna Stimson; Deputy Editors: Uta Goebel, Emily Hu

Online ISSN: 2192-2659

Associated Title(s): Advanced Biosystems, Advanced Functional Materials, Advanced Materials, Advanced Materials Technologies, Advanced Science, Biotechnology Journal, Macromolecular Bioscience, Small

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Recently Published Articles

  1. Tropoelastin Implants That Accelerate Wound Repair

    Suzanne M. Mithieux, Behnaz Aghaei-Ghareh-Bolagh, Leping Yan, Kekini V. Kuppan, Yiwei Wang, Francia Garces-Suarez, Zhe Li, Peter K. Maitz, Elizabeth A. Carter, Christina Limantoro, Wojciech Chrzanowski, David Cookson, Alan Riboldi-Tunnicliffe, Clair Baldock, Kosuke Ohgo, Kristin K. Kumashiro, Glenn Edwards and Anthony S. Weiss

    Version of Record online: 16 FEB 2018 | DOI: 10.1002/adhm.201701206

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    Heat-stabilized tropoelastin provides a novel scalable approach to production of elastic materials. This is attractive because no chemicals are used to generate these elastic structures. The resulting heat-treated tropoelastin promotes the repair of full-thickness wounds.

  2. Multifunctional Cell Instructive Silk-Bioactive Glass Composite Reinforced Scaffolds Toward Osteoinductive, Proangiogenic, and Resorbable Bone Grafts

    Joseph Christakiran Moses, Samit Kumar Nandi and Biman B. Mandal

    Version of Record online: 14 FEB 2018 | DOI: 10.1002/adhm.201701418

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    Silk fibroin (mulberry and endemic Indian non-mulberry silk), a widely renowned biopolymer herein is used to derive cell instructive bone scaffolding platforms. These bioactive glass functionalized silk microfibers reinforce composite matrices dictated stem cell differentiation, matrix maturation, endothelial cell migration, homing and network formation in vitro and consequently help in complete restoration of volumetric bone defects in rabbit femurs.

  3. Tough Composite Hydrogels with High Loading and Local Release of Biological Drugs

    Jianyu Li, Eckhard Weber, Sabine Guth-Gundel, Michael Schuleit, Andreas Kuttler, Christine Halleux, Nathalie Accart, Arno Doelemeyer, Anne Basler, Bruno Tigani, Kuno Wuersch, Mara Fornaro, Michaela Kneissel, Alexander Stafford, Benjamin R. Freedman and David J. Mooney

    Version of Record online: 14 FEB 2018 | DOI: 10.1002/adhm.201701393

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    This work reports biocompatible composite hydrogels with high loading and extremely extended, localized release of biological drugs. The hydrogels demonstrate high mechanical toughness (sustain >80% compressive strains), large drug loading capacity (8 mg mL−1), extended release duration (28 d), and highly localized drug release (the ratio of tissue- and serum-level of the drug >10 000).

  4. Injectable, Tough Alginate Cryogels as Cancer Vaccines

    Ting-Yu Shih, Serena O. Blacklow, Aileen W. Li, Benjamin R. Freedman, Sidi Bencherif, Sandeep T. Koshy, Max C. Darnell and David J. Mooney

    Version of Record online: 14 FEB 2018 | DOI: 10.1002/adhm.201701469

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    Combining covalent and ionic crosslinking of cryogels results in a tough methacrylated-alginate cryogel with improved injectability in vitro and in vivo. The tough-cryogel-based cancer vaccine generates strong antigen-specific cellular and humoral responses in vivo, and induces potent antibreast cancer prophylactic efficacy in mice. The tough cryogels are a promising minimally invasive delivery platform for cancer vaccinations.

  5. Broad-Spectrum Neutralization of Pore-Forming Toxins with Human Erythrocyte Membrane-Coated Nanosponges

    Yijie Chen, Mengchun Chen, Yue Zhang, Joo Hee Lee, Tamara Escajadillo, Hua Gong, Ronnie H. Fang, Weiwei Gao, Victor Nizet and Liangfang Zhang

    Version of Record online: 13 FEB 2018 | DOI: 10.1002/adhm.201701366

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    Biomimetic toxin nanosponges made of human RBC membranes are prepared and tested against four distinct pore-forming toxins. The results demonstrate that the nanosponges can completely inhibit the virulence of the toxins in a concentration-dependent manner both in vitro and in vivo. Similar design and test can be readily applied to other cell membrane-coated nanosponges for broad antivirulence applications.

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