Advanced Healthcare Materials

Cover image for Vol. 6 Issue 17

Editor-in-Chief: Lorna Stimson; Deputy Editors: Uta Goebel, Emily Hu

Online ISSN: 2192-2659

Associated Title(s): Advanced Biosystems, Advanced Functional Materials, Advanced Materials, Advanced Materials Technologies, Advanced Science, Biotechnology Journal, Macromolecular Bioscience, Small

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Recently Published Articles

  1. Controlling Differentiation of Stem Cells for Developing Personalized Organ-on-Chip Platforms

    Armin Geraili, Parya Jafari, Mohsen Sheikh Hassani, Behnaz Heidary Araghi, Mohammad Hossein Mohammadi, Amir Mohammad Ghafari, Sara Hasanpour Tamrin, Hassan Pezeshgi Modarres, Ahmad Rezaei Kolahchi, Samad Ahadian and Amir Sanati-Nezhad

    Version of Record online: 14 SEP 2017 | DOI: 10.1002/adhm.201700426

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    Stem-cell-based organ-on-chips (OOCs) are powerful platforms for drug screening and development. This study discusses different OOCs (e.g., brain, liver, heart, tumor, and lung) with the emphasis on the critical role of stem cells. This further recaps the design, improved functionality, high-throughput performance, technical challenges, and future perspectives of stem-cell-based OOCs.

  2. Tailored Approaches in Drug Development and Diagnostics: From Molecular Design to Biological Model Systems

    Cecilia Sahlgren, Annika Meinander, Hongbo Zhang, Fang Cheng, Maren Preis, Chunlin Xu, Tiina A. Salminen, Diana Toivola, Daniel Abankwa, Ari Rosling, Didem Şen Karaman, Outi M. H. Salo-Ahen, Ronald Österbacka, John E. Eriksson, Stefan Willför, Ion Petre, Jouko Peltonen, Reko Leino, Mark Johnson, Jessica Rosenholm and Niklas Sandler

    Version of Record online: 11 SEP 2017 | DOI: 10.1002/adhm.201700258

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    Recent advances and concepts in novel materials and technologies for drug delivery and diagnostics, illustrating how the convergence of biological, pharmaceutical, and medical disciplines is needed to meet the medical challenges of the 21st century, are covered in this review.

  3. Glycan Stimulation Enables Purification of Prostate Cancer Circulating Tumor Cells on PEDOT NanoVelcro Chips for RNA Biomarker Detection

    Mo-Yuan Shen, Jie-Fu Chen, Chun-Hao Luo, Sangjun Lee, Cheng-Hsuan Li, Yung-Ling Yang, Yu-Han Tsai, Bo-Cheng Ho, Li-Rong Bao, Tien-Jung Lee, Yu Jen Jan, Ya-Zhen Zhu, Shirley Cheng, Felix Y. Feng, Peilin Chen, Shuang Hou, Vatche Agopian, Yu-Sheng Hsiao, Hsian-Rong Tseng, Edwin M. Posadas and Hsiao-hua Yu

    Version of Record online: 11 SEP 2017 | DOI: 10.1002/adhm.201700701

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    A glycan-stimulated and poly(3,4-ethylene-dioxythiophene) (PEDOT)-based nanomaterial platform is fabricated to purify circulating tumor cells. This PEDOT NanoVelcro chip not only provides highly efficient and specific capture of cancer cells but also enables competitive binding of glycan with higher affinity (i.e., sorbitol) to release them. Cancer cells purified are further utilized to correlate disease-related RNA biomarkers in prostate cancer patients.

  4. Fabrication of Trabecular Bone-Templated Tissue-Engineered Constructs by 3D Inkjet Printing

    Joseph P. Vanderburgh, Shanik J. Fernando, Alyssa R. Merkel, Julie A. Sterling and Scott A. Guelcher

    Version of Record online: 11 SEP 2017 | DOI: 10.1002/adhm.201700369

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    A tandem microcomputed tomography/inkjet 3D printing process is developed to fabricate tissue-engineered bone constructs (TEBCs) from human trabecular bone templates. TEBC morphometric properties, trabecular interconnectivity, surface roughness, and mechanical properties resemble those of human bone. Human mesenchymal stem cells cultured on the TEBCs exhibit significantly different metabolic activity, osteogenic differentiation, and mineralization depending on the anatomic site.

  5. Biomimetic Artificial Basilar Membranes for Next-Generation Cochlear Implants

    Jongmoon Jang, Jeong Hun Jang and Hongsoo Choi

    Version of Record online: 11 SEP 2017 | DOI: 10.1002/adhm.201700674

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    Artificial basilar membrane (ABM) is an acoustic transducer that mimics cochlear tonotopy. This Progress Report provides a brief review of the ABMs for next-generation cochlear implants. The scope includes tonotopic characteristics of the ABM, in vivo experiments using animal models, and future perspectives of the ABM for next-generation cochlear implants.