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  1. Synthesis of Self-Assembled Spermidine-Carbon Quantum Dots Effective against Multidrug-Resistant Bacteria

    Yu-Jia Li, Scott G. Harroun, Yu-Chia Su, Chun-Fang Huang, Binesh Unnikrishnan, Han-Jia Lin, Chia-Hua Lin and Chih-Ching Huang

    Version of Record online: 22 JUL 2016 | DOI: 10.1002/adhm.201600297

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    Spermidine, a biogenic polyamine, when self-assembled on carbon quantum dots (CQDs), exhibits >25 000-fold improvement in its antimicrobial activity against multidrug resistant bacteria. Antibacterial wound-healing assays reveal that the spermidine-modified CQDs are an effective dressing nanomaterial for treatment of bacterial infections.

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    3D Bioprinting: 3D Bioprinting Using a Templated Porous Bioink (Adv. Healthcare Mater. 14/2016) (page 1681)

    James P. K. Armstrong, Madeline Burke, Benjamin M. Carter, Sean A. Davis and Adam W. Perriman

    Version of Record online: 20 JUL 2016 | DOI: 10.1002/adhm.201670070

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    A.W. Perriman and co-workers describe a new cell-containing hybrid bio-ink that allows the 3D printing of physiological architectures with templated micropores on page 1724. The printed constructs are then used in cartilage and bone tissue engineering, giving rise to well-distributed extracellular matrix components.

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    Osteoanabolic Implants: Osteoanabolic Implant Materials for Orthopedic Treatment (Adv. Healthcare Mater. 14/2016) (page 1682)

    Yun-Fei Ding, Rachel W. Li, Masaaki Nakai, Trina Majumdar, Dong-Hai Zhang, Mitsuo Niinomi, Nick Birbilis, Paul N. Smith and Xiao-Bo Chen

    Version of Record online: 20 JUL 2016 | DOI: 10.1002/adhm.201670071

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    On page 1740, Xiao-Bo Chen and co-workers report an orthopedic implant material specifically designed for osteoporotic bone fractures. A newl strontium phosphate coating applied to a bone-mimicking low elastic titanium alloy with a comparative Young's modulus to that of natural bone results in upregulating the growth of osteoblasts and downregulating that of osteoclasts. Such a promising osteoanabolic effect reveals a suitability in particular for patients who suffer from low quality bone organism and slow fracture recovery.

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    Osteochondral Regeneration: Tuning Cell Differentiation into a 3D Scaffold Presenting a Pore Shape Gradient for Osteochondral Regeneration (Adv. Healthcare Mater. 14/2016) (page 1832)

    Andrea Di Luca, Ivan Lorenzo-Moldero, Carlos Mota, Antonio Lepedda, Dietmar Auhl, Clemens Van Blitterswijk and Lorenzo Moroni

    Version of Record online: 20 JUL 2016 | DOI: 10.1002/adhm.201670074

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    A combination of human mesenchymal stem cells with additive manufacturing technology for the fabrication of scaffolds with instructive properties is presented by Lorenzo Moroni and co-workers on page 1753. This new fiber deposition pattern allows the generation of pores of different shapes within the same construct. The most rhomboidal pore geometry sustained enhances alkaline phosphatase activity and osteogenic related genes expression with respect to the other gradient zones when the gradient scaffold is cultured in a medium supporting both osteogenic and chondrogenic differentiation. This may contribute to enhance osteochondral regeneration in orthopedic treatments.

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