Advanced Healthcare Materials

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Recently Published Articles

  1. A Platform for Controlled Dual-Drug Delivery to the Retina: Protective Effects against Light-Induced Retinal Damage in Rats

    Nobuhiro Nagai, Hirokazu Kaji, Hideyuki Onami, Yuki Katsukura, Yumi Ishikawa, Zhaleh Kashkouli Nezhad, Kaori Sampei, Satoru Iwata, Shuntaro Ito, Matsuhiko Nishizawa, Toru Nakazawa, Noriko Osumi, Yukihiko Mashima and Toshiaki Abe

    Article first published online: 19 APR 2014 | DOI: 10.1002/adhm.201400114

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    Controlled transscleral co-delivery of two drugs, edaravone (EDV) and unoprostone (UNO), using a platform that comprises a microfabricated reservoir, controlled-release cover, and drug formulations, which are made of photopolymerized poly(ethyleneglycol) dimethacrylates, shows synergistic retinal neuroprotection against light injury in rats when compared with single-drug-loaded devices. The device would offer a safer therapeutic method than intravitreal injections for retinal disease treatments.

  2. Small-Dose-Sensitive X-Ray Image Pixel with HgI2 Photoconductor and Amorphous Oxide Thin-Film Transistor

    Jae Chul Park, Pyo Jin Jeon, Jin Sung Kim and Seongil Im

    Article first published online: 19 APR 2014 | DOI: 10.1002/adhm.201400077

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    A new X-ray image sensor is demonstrated with oxide thin-film transistor backplane and HgI2 sensing material. It displays outstanding image quality under a low X-ray exposure and a low electric field. It is promising as a state-of-the-art device to realize highly resolved images at a low X-ray dose for a variety of medical X-ray imaging applications.

  3. Bioreducible Carboxymethyl Dextran Nanoparticles for Tumor-Targeted Drug Delivery

    Thavasyappan Thambi, Dong Gil You, Hwa Seung Han, V. G. Deepagan, Sang Min Jeon, Yung Doug Suh, Ki Young Choi, Kwangmeyung Kim, Ick Chan Kwon, Gi-Ra Yi, Jun Young Lee, Doo Sung Lee and Jae Hyung Park

    Article first published online: 17 APR 2014 | DOI: 10.1002/adhm.201300691

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    Bioreducible nanoparticles bearing the disulfide bond are developed for the site-specific delivery of poorly water-soluble anticancer drugs at the tumor microenvironment. The nanoparticles are composed of hydrophilic carboxymethyl dextran and hydrophobic bile acid with an intervening disulfide bond. The hydrophilic shells of nanoparticles allow their prolonged circulation in the bloodstream, whereas the bioreducible disulfide bonds trigger the drug release inside the tumor cells after internalization of nanoparticles.

  4. Selection of Functional Human Sperm with Higher DNA Integrity and Fewer Reactive Oxygen Species

    Waseem Asghar, Vanessa Velasco, James L. Kingsley, Muhammad S. Shoukat, Hadi Shafiee, Raymond M. Anchan, George L. Mutter, Erkan Tüzel and Utkan Demirci

    Article first published online: 17 APR 2014 | DOI: 10.1002/adhm.201400058

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    Conventional sperm sorting methods employed in reproductive clinics to treat infertile couples involve centrifugation steps that damage sperm morphology and produce reactive oxygen species (ROS) and DNA fragmentation. Here, a centrifugation-free high-throughput sperm sorting assay that rapidly isolates functional sperm with high DNA integrity and fewer ROS is presented.

  5. Injectable Colloidal Gold in a Sucrose Acetate Isobutyrate Gelating Matrix with Potential Use in Radiation Therapy

    Rasmus I. Jølck, Tina Binderup, Anders E. Hansen, Jonas B. Scherman, Per Munch af Rosenschold, Andreas Kjær and Thomas L. Andresen

    Article first published online: 15 APR 2014 | DOI: 10.1002/adhm.201300668

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    A liquid injectable fiducial marker (nanogel) based on acylated sucrose and PEGylated gold nanoparticles with potential use in image-guided radiation therapy is evaluated in vitro and in vivo. The excellent X-ray contrast, high stability in vivo, high biocompatibility, and ease of administration make it a promising platform for use in radiation therapy.