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Recently Published Articles

  1. Microfluidic Organ-on-a-Chip Technology for Advancement of Drug Development and Toxicology

    Jeremy D. Caplin, Norma G. Granados, Myra R. James, Reza Montazami and Nastaran Hashemi

    Article first published online: 26 MAR 2015 | DOI: 10.1002/adhm.201500040

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    Current technologies pertaining to organ-on-a-chip systems are studied and analyzed in this Review. A systematic approach is taken, in which research conducted on each organ is compiled and individually analyzed. Particular attention is brought to the design processes and the experimental layout. Finally, multi-organ systems are analyzed and scaling laws for these systems are presented, with a final goal of creating a “human-on-a-chip.”

  2. Oxide Nanomembrane Hybrids with Enhanced Mechano- and Thermo-Sensitivity for Semitransparent Epidermal Electronics

    Minjoon Park, Kyungsik Do, Jaemin Kim, Donghee Son, Ja Hoon Koo, Jinkyung Park, Jun-Kyul Song, Ji Hoon Kim, Minbaek Lee, Taeghwan Hyeon and Dae-Hyeong Kim

    Article first published online: 23 MAR 2015 | DOI: 10.1002/adhm.201500097

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    Oxide nanomembrane hybrids with enhanced mechano- and thermo-sensitivity for semitransparent epidermal electronics are developed. The use of nanomaterials (single wall nanotubes and silver nanoparticles) embedded in the oxide nanomembranes significantly enhances mechanical and thermal sensitivities. These mechanical and thermal sensors are utilized in wheelchair control and hypothermia detection, which are useful for patients with strokes.

  3. Blended Nanoparticle System Based on Miscible Structurally Similar Polymers: A Safe, Simple, Targeted, and Surprisingly High Efficiency Vehicle for Cancer Therapy

    Wei Tao, Jinxie Zhang, Xiaowei Zeng, Danny Liu, Gan Liu, Xi Zhu, Yanlan Liu, Qingtong Yu, Laiqiang Huang and Lin Mei

    Article first published online: 19 MAR 2015 | DOI: 10.1002/adhm.201400751

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    A novel blended nanoparticle (NP) system for the delivery of anticancer drugs and its surprisingly high efficacy for cancer chemotherapy by blending a targeting polymer folic acid-poly(ethylene glycol)-b-poly(lactide- co-glycolide) (FA-PEG-b-PLGA) and a miscible structurally similar polymer D-α-tocopheryl polyethylene glycol 1000 succinate-poly(lactide-co-glycolide) (TPGS-PLGA) are reported. This blended NP system can be achieved through a simple and effective nanoprecipitation technique, possessing unique properties.

  4. Incorporation of TGF-Beta 3 within Collagen–Hyaluronic Acid Scaffolds Improves their Chondrogenic Potential

    Amos Matsiko, Tanya J. Levingstone, John P. Gleeson and Fergal J. O'Brien

    Article first published online: 19 MAR 2015 | DOI: 10.1002/adhm.201500053

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    Incorporation of therapeutics in the form of growth factors within biomaterials can enhance their biofunctionality. Two methods of incorporating transforming growth factor-beta 3 within collagen–hyaluronic acid scaffolds are described, markedly improving mesenchymal stem cell-mediated chondrogenic differentiation and matrix production. Such scaffolds offer control over the release of therapeutics, demonstrating their potential for repair of complex chondral defects requiring additional stimuli.

  5. Generation and Assessment of Functional Biomaterial Scaffolds for Applications in Cardiovascular Tissue Engineering and Regenerative Medicine

    Svenja Hinderer, Eva Brauchle and Katja Schenke-Layland

    Article first published online: 16 MAR 2015 | DOI: 10.1002/adhm.201400762

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    Various biomaterial design and generation methods for myocardial, heart valve, and blood vessel engineering are reviewed. In vitro and in vivo studies as well as clinical trials are discussed and novel contact- and marker-free biomaterial and extracellular matrix assessment methods are highlighted.