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Recently Published Articles

  1. Extracellular Matrix-Based Biohybrid Materials for Engineering Compliant, Matrix-Dense Tissues

    Laura G. Bracaglia and John P. Fisher

    Article first published online: 30 JUL 2015 | DOI: 10.1002/adhm.201500236

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    Materials made by incorporating polymer components with extracellular matrix (ECM)-derived proteins capitalize on polymer mechanical and degradation properties while still actively guiding tissue remodeling. These characteristics are paramount in engineering a tissue to withstand the force from the environment throughout the remodeling process in skin, vasculature, tendon, and intestinal wall reconstruction.

  2. Engineering Nanoscale Stem Cell Niche: Direct Stem Cell Behavior at Cell–Matrix Interface

    Yan Zhang, Andrew Gordon, Weiyi Qian and Weiqiang Chen

    Article first published online: 29 JUL 2015 | DOI: 10.1002/adhm.201500351

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    Recent exciting advances in nanotechnology and materials science have enabled versatile, robust, and large-scale stem cell engineering in vitro through developments of synthetic nanotopographic surfaces mimicking topological features of stem cell niches. This Progress Report provides a summary of recent progress on emerging methods for generating nanotopographic surfaces and their applications in stem cell research.

  3. Bioinspired Nanoparticulate Medical Glues for Minimally Invasive Tissue Repair

    Yuhan Lee, Chenjie Xu, Monisha Sebastin, Albert Lee, Nathan Holwell, Calvin Xu, David Miranda Nieves, Luye Mu, Robert S. Langer, Charles Lin and Jeffrey M. Karp

    Article first published online: 27 JUL 2015 | DOI: 10.1002/adhm.201500419

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    Methods to deliver viscous medical glues to tissues through small incisions or with small channels are critical for minimally invasive surgeries. Inspired by the granule-packaged glue delivery system of sandcastle worms, nanoparticulate formulation of viscous hydrophobic light-activated adhesive based on poly(glycerol sebacate)-acrylate is shown here.

  4. Nanomechanics of Cells and Biomaterials Studied by Atomic Force Microscopy

    Jason I. Kilpatrick, Irène Revenko and Brian J. Rodriguez

    Article first published online: 22 JUL 2015 | DOI: 10.1002/adhm.201500229

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    Atomic force microscopy is an indispensable tool for nanomechanical measurements of cells, cell microenvironments, and biomaterials. The mechanical properties of cells and their function are influenced by the elasticity of the extracellular matrix. Thus, understanding the nanomechanical properties is key for tissue engineering applications.

  5. Bright Lu2O3:Eu Thin-Film Scintillators for High-Resolution Radioluminescence Microscopy

    Debanti Sengupta, Stuart Miller, Zsolt Marton, Frederick Chin, Vivek Nagarkar and Guillem Pratx

    Article first published online: 16 JUL 2015 | DOI: 10.1002/adhm.201500372

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    Thin-film Lu2O3:Eu scintillators are used to successfully produce high-resolution images of glucose uptake in human cancer cells. The sensitivity of this novel material is quantified and shown to be a fourfold improvement over previously used thicker CdWO4-based scintillators. This work has key implications for high-resolution and real-time imaging of cell metabolism using radiotracers.