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Recently Published Articles

  1. Effective Targeted Photothermal Ablation of Multidrug Resistant Bacteria and Their Biofilms with NIR-Absorbing Gold Nanocrosses

    Choon Peng Teng, Tielin Zhou, Enyi Ye, Shuhua Liu, Leng Duei Koh, Michelle Low, Xian Jun Loh, Khin Yin Win, Lianhui Zhang and Ming-Yong Han

    Version of Record online: 23 JUN 2016 | DOI: 10.1002/adhm.201600346

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    Multiple branched gold nanostructures with strong near-infrared absorption are synthesized and conjugated with primary and secondary antibodies for effective targeted photothermal ablation of multidrug-resistant bacteria, which have become increasingly difficult to be treated with clinically available antibiotics. This method improves the efficiency in eliminating bacteria/biofilms and offers flexibility by changing the corresponding primary antibodies to target other bacteria strains.

  2. Synergistic Combination of Multistage Magnetic Guidance and Optimized Ligand Density in Targeting a Nanoplatform for Enhanced Cancer Therapy

    Chih-Sheng Chiang, Yi-Shang Shen, Jun-Jen Liu, Woei-Cherng Shyu and San-Yuan Chen

    Version of Record online: 23 JUN 2016 | DOI: 10.1002/adhm.201600479

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    Trastuzumab-targeted, doxorubicin-encapsulated magnetic nanocarriers (T-Dox-MNCs) synthesized using thiol-functionalized poly(methacrylic acid)-grafted poly(vinyl alcohol) copolymer (PVA/PMASH) and superparamagnetic nanoparticles can generate tunable bridging sites for precise Tra conjugation and controlled pH-sensitive drug release. With precise Tra density and multiple-stage magnetic targeting, localized accumulation and intratumoral distribution of therapeutic T-Dox-MNCs are improved, increasing the efficient efficacy of the cancer therapy.

  3. Wrinkled-Surface Mediated Reverse Transfection Platform for Highly Efficient, Addressable Gene Delivery

    Hyunwoo Joo, Jisoo Shin, Seung-Woo Cho and Pilnam Kim

    Version of Record online: 23 JUN 2016 | DOI: 10.1002/adhm.201600354

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    A novel reverse transfection platform, which embraces a wrinkled-surface, is developed for highly efficient long-term gene delivery. Since reverse transfection utilizes the contact between cell and substrate, the increase in the contact area between substrate and cells significantly increases the gene delivery rate. Furthermore, by adopting microwell structures, multiplex, addressable delivery of exogenous materials is successfully demonstrated.

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    3D Bioprinting Using a Templated Porous Bioink

    James P. K. Armstrong, Madeline Burke, Benjamin M. Carter, Sean A. Davis and Adam W. Perriman

    Version of Record online: 29 APR 2016 | DOI: 10.1002/adhm.201600022

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    3D tissue printing with adult stem cells is reported. A novel cell-containing multicomponent bioink is used in a two-step 3D printing process to engineer bone and cartilage architectures.

  5. Human Skin Constructs with Spatially Controlled Vasculature Using Primary and iPSC-Derived Endothelial Cells

    Hasan E. Abaci, Zongyou Guo, Abigail Coffman, Brian Gillette, Wen-han Lee, Samuel K. Sia and Angela M. Christiano

    Version of Record online: 22 JUN 2016 | DOI: 10.1002/adhm.201500936

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    Human skin equivalents with perfusable and preorganized vasculature are developed using both primary- and induced-pluripotent-stem-cell-derived endothelial cells. The vascularized human skin equivalents, which have a robust epidermis and endothelial barrier function, enable the study of systemic delivery of drugs in vitro. In addition, they both promote and guide neovascularization during wound healing in mice.