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Recently Published Articles

  1. Engineering-Aligned 3D Neural Circuit in Microfluidic Device

    Seokyoung Bang, Sangcheol Na, Jae Myung Jang, Jinhyun Kim and Noo Li Jeon

    Article first published online: 2 SEP 2015 | DOI: 10.1002/adhm.201500397

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    A novel microfluidic platform for formation of 3D neural circuit is reported. Microfluidic channels are filled with Matrigel and hydrostatic pressure is maintained across the width of the gel during cross-linking. This generates aligned extracellular matrix (ECM) structures in the Matrigel to guide the axon growth direction. Compared to neurons cultured in randomly cross-linked Matrigel, axon bundles that connect pre-/post-synaptic neurons can be formed.

  2. Magnetic Nanoparticles Labeled Mesenchymal Stem Cells: A Pragmatic Solution toward Targeted Cancer Theranostics

    Abhalaxmi Singh, Sumeet Jain, Shantibhusan Senapati, Rama Shanker Verma and Sanjeeb K. Sahoo

    Article first published online: 1 SEP 2015 | DOI: 10.1002/adhm.201500343

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    Mesenchymal stem cells (MSCs) can be labeled with magnetic nanoparticles (MNPs) in vitro without altering their inherent properties like differentiation and tumor specific migration ability. Most of the MNPs labeled MSCs get sequestered in organs like liver during intravenous administration which can be minimized through intraperitoneal administration, providing a better approach for delivery of MNPs at the tumor site.

  3. Electrospun Polycaprolactone 3D Nanofibrous Scaffold with Interconnected and Hierarchically Structured Pores for Bone Tissue Engineering

    Tao Xu, Jacob M. Miszuk, Yong Zhao, Hongli Sun and Hao Fong

    Article first published online: 1 SEP 2015 | DOI: 10.1002/adhm.201500345

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    Electrospun polycaprolactone 3D nanofibrous scaffold with interconnected and hierarchically structured pores is morphologically/structurally similar to natural extracellular matrix (ECM), hence well suited for cell functions and tissue formation. The in vitro results indicate that the novel scaffold supports mouse bone marrow mesenchymal stem cells' osteogenic differentiation, while the in vivo results suggest that it acts as favorable synthetic ECM for the physiological process of endochondral ossification.

  4. Polymer Surface Interacts with Calcium in Aqueous Media to Induce Stem Cell Assembly

    Kun-Che Hung and Shan-hui Hsu

    Article first published online: 1 SEP 2015 | DOI: 10.1002/adhm.201500374

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    Smart surfaces that respond in different extents to Ca2+ in aqueous media are developed based on polyurethane anionomers. The surface may respond with fast recruitment of carboxyl and amino groups (“flip-out”) and form surface cage that facilitates the Ca2+ transport. The interface rearrangement triggers calcium trafficking and turns on signals involving cell merging. Nature-inspired smart interfaces may transport ions for improved functions or be utilized for tissue buildup.

  5. A Silk Sericin/Silicone Nerve Guidance Conduit Promotes Regeneration of a Transected Sciatic Nerve

    Hongjian Xie, Wen Yang, Jianghai Chen, Jinxiang Zhang, Xiaochen Lu, Xiaobo Zhao, Kun Huang, Huili Li, Panpan Chang, Zheng Wang and Lin Wang

    Article first published online: 1 SEP 2015 | DOI: 10.1002/adhm.201500355

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    Sericin, a natural protein and a major component of silk, is crosslinked to fabricate a novel nerve guidance conduit with physical and chemical properties designed toward optimal nerve regeneration. When this conduit is implanted to a rat sciatic nerve transection model, it effectively promotes peripheral nerve regeneration, leading to significant histological and functional recovery.