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Recently Published Articles

  1. LumeNEXT: A Practical Method to Pattern Luminal Structures in ECM Gels

    José A. Jiménez-Torres, Stephen L. Peery, Kyung E. Sung and David J. Beebe

    Article first published online: 26 NOV 2015 | DOI: 10.1002/adhm.201500608

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    In vitro biomimetic modeling of physio­logical structures bridges the gap between 2D in vitro culture and animal models. Lumens (tubular structures) are ubiquitous in vivo, being present in blood vessels, mammary ducts, and the lymphatic system. A method ‘LumeNEXT' is presented here that allows the fabrication of 3D embedded lumens where size, structure, distance, and configuration can be controlled using standard poly­dimethylsiloxane micromolding methods.

  2. Biological and Tribological Assessment of Poly(Ethylene Oxide Terephthalate)/Poly(Butylene Terephthalate), Polycaprolactone, and Poly (L\DL) Lactic Acid Plotted Scaffolds for Skeletal Tissue Regeneration

    Wilhelmus J. Hendrikson, Xiangqiong Zeng, Jeroen Rouwkema, Clemens A. van Blitterswijk, Emile van der Heide and Lorenzo Moroni

    Article first published online: 25 NOV 2015 | DOI: 10.1002/adhm.201500067

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    Poly(caprolactone), poly(L/DL)lactic-acid and poly(ethylene oxide terephthalate)/poly(butylene terephthalate) scaffolds are tested for their biological and tribological behavior. The biomaterials are compared biologically by exposing stem-cell-seeded scaffolds to differentiation media. The effects of biomaterial and scaffold architecture on friction are assessed. The best performing biomaterial and architecture are combined to investigate the influence of extracellular matrix formation on friction coefficient.

  3. Sensing and Sensibility: Single-Islet-based Quality Control Assay of Cryopreserved Pancreatic Islets with Functionalized Hydrogel Microcapsules

    Wanyu Chen, Zhiquan Shu, Dayong Gao and Amy Q. Shen

    Article first published online: 25 NOV 2015 | DOI: 10.1002/adhm.201500515

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    The single-islet-based quality control assay consists of a droplet microfluidic device for islet encapsulation with alginate hydrogel, with oxygen sensitive dye embedded in the capsules for quality control, with an optimized cryopreservation protocol.

  4. Exploring the Potential of Starch/Polycaprolactone Aligned Magnetic Responsive Scaffolds for Tendon Regeneration

    Ana I. Gonçalves, Márcia T. Rodrigues, Pedro P. Carvalho, Manuel Bañobre-López, Elvira Paz, Paulo Freitas and Manuela E. Gomes

    Article first published online: 25 NOV 2015 | DOI: 10.1002/adhm.201500623

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    3D rapid prototyped scaffolds with aligned architecture and magnetic responsiveness promote tenogenic differentiation of adipose stem cells with increasing ECM deposition stimulated by an externally applied magnetic field. The magnetic scaffolds also show biocompatibility in an ectopic rat model. These findings guide the rational design of magnetically responsive scaffolds mimicking tendon microenvironment and enabling the combination of therapeutic and diagnostic tools.

  5. Gallium-Loaded Dissolvable Microfilm Constructs that Provide Sustained Release of Ga3+ for Management of Biofilms

    Maggie Herron, Michael J. Schurr, Christopher J. Murphy, Jonathan F. McAnulty, Charles J. Czuprynski and Nicholas L. Abbott

    Article first published online: 24 NOV 2015 | DOI: 10.1002/adhm.201500599

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    Bacterial biofilms have been shown to delay the healing of wounds. Here, the incorporation of the antibiofilm agent Ga3+ into polymeric nanofilms, modification of the nanofilms by cross-linking to control the release rate of Ga3+, integration of the nanofilms onto wound dressings using micrometer-thick water-soluble casts, and the effectiveness of the nanofilms in inhibiting and dispersing biofilms are reported.