Advanced Healthcare Materials

Cover image for Vol. 6 Issue 14

Editor-in-Chief: Lorna Stimson; Deputy Editor: Uta Goebel

Online ISSN: 2192-2659

Associated Title(s): Advanced Biosystems, Advanced Functional Materials, Advanced Materials, Advanced Materials Technologies, Advanced Science, Biotechnology Journal, Macromolecular Bioscience, Small

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Recently Published Articles

  1. Mechanically Tunable Bioink for 3D Bioprinting of Human Cells

    Aurelien Forget, Andreas Blaeser, Florian Miessmer, Marius Köpf, Daniela F. Duarte Campos, Nicolas H. Voelcker, Anton Blencowe, Horst Fischer and V. Prasad Shastri

    Version of Record online: 21 JUL 2017 | DOI: 10.1002/adhm.201700255

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    Carboxylated agarose hydrogels with mechanical property independent of the bioink solution viscosity allow the high-viability 3D bioprinting of human mesenchymal stem cells. Furthermore, addition of collagen to the carboxylated agarose induces the proliferation of the human mesenchymal stem cells used in this study.

  2. Targeted Nanotherapeutics Encapsulating Liver X Receptor Agonist GW3965 Enhance Antiatherogenic Effects without Adverse Effects on Hepatic Lipid Metabolism in Ldlr−/− Mice

    Mikyung Yu, Jaume Amengual, Arjun Menon, Nazila Kamaly, Felix Zhou, Xiaoding Xu, Phei Er Saw, Seung-Joo Lee, Kevin Si, Carleena Angelica Ortega, Won Il Choi, In-Hyun Lee, Yazan Bdour, Jinjun Shi, Morteza Mahmoudi, Sangyong Jon, Edward A. Fisher and Omid C. Farokhzad

    Version of Record online: 21 JUL 2017 | DOI: 10.1002/adhm.201700313

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    A new form of liver X receptor-based therapeutics based on the nanoparticles (NPs) decorated with collagen IV targeting ligands is generated. The NPs with optimal polyethylene glycol density can successfully reach atherosclerotic lesions and enhance therapeutic efficacy of GW3965 while maintaining hepatic lipid metabolism. This targeted NP system suggests a new modality for combating inflammation in advanced atherosclerosis.

  3. Aspherical, Nanostructured Microparticles for Targeted Gene Delivery to Alveolar Macrophages

    Michael Möhwald, Shashank Reddy Pinnapireddy, Bodo Wonnenberg, Marcel Pourasghar, Marijas Jurisic, Andrea Jung, Claudia Fink-Straube, Thomas Tschernig, Udo Bakowsky and Marc Schneider

    Version of Record online: 20 JUL 2017 | DOI: 10.1002/adhm.201700478

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    A novel aspherical, nanostructured microparticle for pulmonary gene delivery is fabricated utilizing a template-assisted engineering technique. Here, nanoparticles build up rod-like shaped structures in the micrometer size range, stabilized with plasmid-DNA and polyethylenimine. The carrier provides the introduction of genes into alveolar macrophages both in vitro and in vivo, qualifying the system for the genetic engineering of immunocompetent phagocytes.

  4. Retardation of Antigen Release from DNA Hydrogel Using Cholesterol-Modified DNA for Increased Antigen-Specific Immune Response

    Yuka Umeki, Masaaki Saito, Yuki Takahashi, Yoshinobu Takakura and Makiya Nishikawa

    Version of Record online: 20 JUL 2017 | DOI: 10.1002/adhm.201700355

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    A hydrophobic interaction-based sustained release system of ovalbumin (OVA), a model antigen, from immunostimulatory cytosine-phosphate-guanine (CpG) DNA hydrogel is developed by the use of cholesterol-modified DNA and urea-denatured OVA, and this system efficiently inhibits tumor growth. This study further supports the importance of sustained release of both antigen and CpG DNA to induce antigen-specific immune responses.

  5. Multifunctional Nanotube–Mucoadhesive Poly(methyl vinyl ether-co-maleic acid)@Hydroxypropyl Methylcellulose Acetate Succinate Composite for Site-Specific Oral Drug Delivery

    Nattha Kerdsakundee, Wei Li, João Pedro Martins, Zehua Liu, Feng Zhang, Marianna Kemell, Alexandra Correia, Yaping Ding, Mikko Airavaara, Jouni Hirvonen, Ruedeekorn Wiwattanapatapee and Hélder A. Santos

    Version of Record online: 17 JUL 2017 | DOI: 10.1002/adhm.201700629

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    Multifunctional nano-in-micro particles composed of mucoadhesive polymer modified halloysite nanotubes and pH-responsive polymer are developed by microfluidics for oral drug delivery applications. The microparticles can release the drug site specifically in response to the pH condition of small intestine, strongly interact with small intestine, and significantly increase the permeability of a poorly water-soluble drug.

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