Advanced Healthcare Materials

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Recently Published Articles

  1. Targeting and Microenvironment-Responsive Lipid Nanocarrier for the Enhancement of Tumor Cell Recognition and Therapeutic Efficiency

    Wei Gao, Tingting Meng, Nianqiu Shi, Hongmeng Zhuang, Zhenzhen Yang and Xianrong Qi

    Article first published online: 17 DEC 2014 | DOI: 10.1002/adhm.201400675

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    Folic acid and tumor microenvironment-sensitive polypeptide (TMSP) co-modified lipid-nanocarrier (F/TMSP-NLC) are successfully formulated in response to the overexpression of folate receptor and the upregulation of matrix metalloproteinase-2 (MMP-2) in tumor microenvironment. The present nanocarrier modified with both TMSP and folic acid is a potential drug delivery system for tumor cell recognition and therapy.

  2. Laser 3D Printing with Sub-Microscale Resolution of Porous Elastomeric Scaffolds for Supporting Human Bone Stem Cells

    Peter E. Petrochenko, Jan Torgersen, Peter Gruber, Lucas A. Hicks, Jiwen Zheng, Girish Kumar, Roger J. Narayan, Peter L. Goering, Robert Liska, Jürgen Stampfl and Aleksandr Ovsianikov

    Article first published online: 17 DEC 2014 | DOI: 10.1002/adhm.201400442

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    Fabrication of scaffolds by two-photon polymerization (2PP) of a biodegradable urethane and acrylate-based photoelastomer is demonstrated. This material supports 2PP processing with sub-micrometer spatial resolution. The high photoreactivity of the biophoto­elastomer permits 2PP processing at a scanning speed of 1000 mm s−1, facilitating rapid fabrication of large structures (>5 mm3). Stable scaffolds with porosities of greater than 60% can be produced using 2PP.

  3. Biomineral Coating Increases Bone Formation by Ex Vivo BMP-7 Gene Therapy in Rapid Prototyped Poly(l-lactic acid) (PLLA) and Poly(ε-caprolactone) (PCL) Porous Scaffolds

    Eiji Saito, Darilis Suarez-Gonzalez, William L. Murphy and Scott J. Hollister

    Article first published online: 16 DEC 2014 | DOI: 10.1002/adhm.201400424

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    The combination of indirect solid freeform fabrication (SFF) technique and biomineral coating is applied to create scaffolds from two kinds of base materials, poly (l-lactic acid) (PLLA) and poly (ε-caprolactone) (PCL), with the same architecture, and able to improve in vivo bone ingrowth. The improved bone ingrowth compensates scaffold mechanical loss during its degradation.

  4. Plasmon-Coupled Gold Nanospheres for Two-Photon Imaging and Photoantibacterial Activity

    Peiyan Yuan, Xin Ding, Zhenping Guan, Nengyue Gao, Rizhao Ma, Xiao-Fang Jiang, Yi Yan Yang and Qing-Hua Xu

    Article first published online: 15 DEC 2014 | DOI: 10.1002/adhm.201400524

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    Positively charged Au nanospheres are found to form aggregates on the bacterial surface, resulting in significantly enhanced two-photon photoluminescence (TPPL). The enhanced TPPL is successfully utilized to image bacterial cells in the NIR region. In addition, these Au NSs effectively eradicate the bacterial cells by laser pulses in the same NIR region due to the photothermal effect.

  5. You have free access to this content
    Advanced Functional Polymers for Medicine (pages 1939–1940)

    Andreas Lendlein, Axel T. Neffe and Christine Jérôme

    Article first published online: 9 DEC 2014 | DOI: 10.1002/adhm.201400718