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Recently Published Articles

  1. Bottom-Up Engineering of Well-Defined 3D Microtissues Using Microplatforms and Biomedical Applications

    Geon Hui Lee, Jae Seo Lee, Xiaohong Wang and Sang Hoon Lee

    Article first published online: 16 APR 2015 | DOI: 10.1002/adhm.201500107

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    Engineering of 3D tissues, which are building blocks for the bottom-up engineering, has been widely developed with the advances of micro-technologies. This article gives an overview of those micro-technologies that facilitate providing well defined 3D tissues and in vivo mimicking platforms, and reports the applications of 3D tissues and future directions.

  2. Photocrosslinkable Gelatin Hydrogel for Epidermal Tissue Engineering

    Xin Zhao, Qi Lang, Lara Yildirimer, Zhi Yuan Lin, Wenguo Cui, Nasim Annabi, Kee Woei Ng, Mehmet R. Dokmeci, Amir M. Ghaemmaghami and Ali Khademhosseini

    Article first published online: 16 APR 2015 | DOI: 10.1002/adhm.201500005

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    A photocrosslinkable, biodegradable, naturally derived hydrogel, gelatin methacrylamide, with tunable mechanical and degradation properties, is developed for skin tissue regeneration. The engineered hydrogels can support keratinocyte adhesion, proliferation, and differentiation to form a multilayered epidermis with barrier functions.

  3. Cell and Tissue Imaging with Molecularly Imprinted Polymers as Plastic Antibody Mimics

    Stephanie Kunath, Maria Panagiotopoulou, Jacqueline Maximilien, Nataliya Marchyk, Jörg Sänger and Karsten Haupt

    Article first published online: 16 APR 2015 | DOI: 10.1002/adhm.201500145

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    Molecularly imprinted polymers can be used as “plastic antibodies” for cell and tissue imaging, as demonstrated using hyaluronan on cell surfaces as a model target. Fluorescent nanoparticles binding a hyaluronan substructure, glucuronic acid, are used to image fixated and living cells and tissues. Plastic antibodies can be tailored to specific targets and easily labeled, and are physically and chemically stable.

  4. Cell Invasion in Collagen Scaffold Architectures Characterized by Percolation Theory

    Jennifer C. Ashworth, Marco Mehr, Paul G. Buxton, Serena M. Best and Ruth E. Cameron

    Article first published online: 16 APR 2015 | DOI: 10.1002/adhm.201500197

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    The relationship between biological scaffold interconnectivity and cell migration is an important but poorly understood factor in tissue regeneration. Here a scale-independent technique for characterization of collagen scaffold interconnectivity is presented, using a combination of X-ray microcomputed tomography and percolation theory. Confocal microscopy of connective tissue cells reveals this technique as highly relevant for determining the extent of cell invasion.

  5. A New Approach for Fabricating Collagen/ECM-Based Bioinks Using Preosteoblasts and Human Adipose Stem Cells

    Hyeong Jin Lee, Yong Bok Kim, Seung Hyun Ahn, Ji-Seon Lee, Chul Ho Jang, Hyeon Yoon, Wook Chun and Geun Hyung Kim

    Article first published online: 15 APR 2015 | DOI: 10.1002/adhm.201500193

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    A strategy for obtaining bioactive collagen/ECM-based bioinks without using toxic chemical cross-linking agents is proposed. This approach uses type-I collagen and the extracellular matrix (ECM) secreted from the cultured cells during a 3-day culture. The cell-laden ECM/collagen and alginate are mixed to obtain reasonable printability, and the bioink is used to fabricate 3D porous cell blocks using a cell-printing method, supplemented by an aerosol cross-linking process.

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