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Recently Published Articles

  1. Design and Printing Strategies in 3D Bioprinting of Cell-Hydrogels: A Review

    Jia Min Lee and Wai Yee Yeong

    Version of Record online: 21 OCT 2016 | DOI: 10.1002/adhm.201600435

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    3D bioprinting of tissue for in vivo application requires comprehensive considerations in multiple aspects including design factors, design considerations, process capabilities, printing parameters and crosslinking strategies. The mapping of material-process-design will inspire future biomaterials research and encourage systematic engineering design in bioprinting. The opportunities and outlook in 3D bioprinting are highlighted in this article.

  2. Targeted Dual pH-Sensitive Lipid ECO/siRNA Self-Assembly Nanoparticles Facilitate In Vivo Cytosolic sieIF4E Delivery and Overcome Paclitaxel Resistance in Breast Cancer Therapy

    Maneesh Gujrati, Amita M. Vaidya, Margaret Mack, Dayton Snyder, Anthony Malamas and Zheng-Rong Lu

    Version of Record online: 10 OCT 2016 | DOI: 10.1002/adhm.201600677

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    Targeted dual pH-sensitive RGD-PEG(HZ)-ECO/siRNA nanoparticles facilitate effective cytosolic siRNA delivery in cancer cells and result in effective gene silencing for at least a week in MDA-MB-231 tumors. Intravenous injections of RGD-PEG(HZ)-ECO/siRNA nanoparticles specific to eIF4E resensitize drug-resistant MDA-MB-231 breast cancer to paclitaxel, resulting in significant tumor regression, with negligible side effects.

  3. Engineered Basement Membranes for Regenerating the Corneal Endothelium

    Rachelle N. Palchesko, James L. Funderburgh and Adam W. Feinberg

    Version of Record online: 10 OCT 2016 | DOI: 10.1002/adhm.201600488

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    Human and bovine corneal endothelial cells are cultured on engineered basement membranes (EBM) designed to mimic the structure of the native Descemet's membrane. Culturing these cells on the EBMs increases monolayer cell density compared to standard compressed collagen I gels. Additionally, the cells on the EBMs have more robust ZO-1 and more cortical F-actin stress fibers.

  4. Theranostic Bioabsorbable Bone Fixation Plate with Drug-Layered Double Hydroxide Nanohybrids

    Myung Hun Kim, Woojune Hur, Goeun Choi, Hye Sook Min, Tae Hyun Choi, Young Bin Choy and Jin-Ho Choy

    Version of Record online: 10 OCT 2016 | DOI: 10.1002/adhm.201600761

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    The combination of a biodegradable bone plate with a theranostic sheet containing risedronate, an anti-resorptive bone remodeling drug, intercalated layered double hydroxide nanohybrid as a theranostic agent, and poly(lactic-co-glycolic-acid) as a binder can constitute a promising system with theranostic ability in both X-ray diagnosis and expedited bone repair.

  5. Regulating Stem Cell Secretome Using Injectable Hydrogels with In Situ Network Formation

    Lei Cai, Ruby E. Dewi, Andrew B. Goldstone, Jeffrey E. Cohen, Amanda N. Steele, Y. Joseph Woo and Sarah C. Heilshorn

    Version of Record online: 6 OCT 2016 | DOI: 10.1002/adhm.201600497

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    A family of shear-thinning hydrogels for injectable encapsulation and long-term delivery (SHIELD) has been designed and synthesized with controlled in situ stiffening properties to regulate the stem cell secretome. The authors demonstrate that SHIELD with an intermediate stiffness (200–400 Pa) could significantly promote the angiogenic potential of human adipose-derived stem cells.