Advanced Healthcare Materials

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Recently Published Articles

  1. Co-Delivery of Antiviral and Antifungal Therapeutics for the Treatment of Sexually Transmitted Infections using a Moldable, Supramolecular Hydrogel

    Ashlynn L.Z. Lee, Victor W.L. Ng, Ghim Lee Poon, Xiyu Ke, James L. Hedrick and Yi Yan Yang

    Article first published online: 18 SEP 2014 | DOI: 10.1002/adhm.201400340

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    A topically applied antiviral/antifungal hydrogel that can potentially enhance HIV prevention and simultaneously circumvent sexually transmitted infections (STIs) is presented. The entrapment of antiretroviral drug tenofovir within hydrogels enables an appreciably sustained release of the drug. Hydrogels loaded with antimicrobial polymers effectively eradicate the biomass and reduce the viability of microbes residing as Candida albicans biofilms.

  2. Tapered Microtract Array Platform for Antimigratory Drug Screening of Human Glioblastoma Multiforme

    Junghwa Cha, Ilkyoo Koh, Yemuk Choi, Jungwhoi Lee, Chulhee Choi and Pilnam Kim

    Article first published online: 17 SEP 2014 | DOI: 10.1002/adhm.201400384

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    Tapered microtract array platform (TMAP), which mimics the anatomical features of brain tissue, induces the native characteristics and behavior of glioma cells by topographic cues. The glioma cells on the TMAP exhibit remarkable phenotype transition (crawling-to-saltatory migration). By simply varying the topographic cues, the TMAP can be employed to efficiently screen anti-cancer drug of human brain tumor cells.

  3. Inhibition of Angiogenesis by Antioxidant Micelles

    Masaki Moriyama, Stéphanie Metzger, André J. van der Vlies, Hiroshi Uyama, Martin Ehrbar and Urara Hasegawa

    Article first published online: 11 SEP 2014 | DOI: 10.1002/adhm.201400249

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    Antioxidant micelles having catechol moieties in the core efficiently inhibit angiogenesis by scavenging reactive oxygen species as shown in the human umbilical vein endothelial cells (HUVECs) tube formation and ex ovo chicken chorioallantoic membrane (CAM) assay. These micelles may be useful in anti-angiogenic therapy to treat various diseases such as cancer.

  4. Elongation of Fibers from Highly Viscous Dextran Solutions Enables Fabrication of Rapidly Dissolving Drug Carrying Fabrics

    John P. Frampton, David Lai, Maxwell Lounds, Kyeongwoon Chung, Jinsang Kim, John F. Mansfield and Shuichi Takayama

    Article first published online: 10 SEP 2014 | DOI: 10.1002/adhm.201400287

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    A new method for creating fabrics composed entirely of dextran shows promise for use as a topical drug delivery system for antibiotics and hemostatic agents. This method uses the cohesive and adhesive forces of a highly viscous dextran solution to elongate fibers of approximately 10 μm in diameter between two substrates.

  5. You have free access to this content
    Masthead: (Adv. Healthcare Mater. 9/2014)

    Article first published online: 8 SEP 2014 | DOI: 10.1002/adhm.201470046