Advanced Healthcare Materials
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Recently Published Articles
- Desmoplastic Reaction in 3D-Pancreatic Cancer Tissues Suppresses Molecular Permeability
Michiya Matsusaki, Misaki Komeda, Simona Mura, Hiroyoshi Y. Tanaka, Mitsunobu R. Kano, Patrick Couvreur and Mitsuru Akashi
Version of Record online: 27 APR 2017 | DOI: 10.1002/adhm.201700057
The design and characterization of in vitro pancreatic cancer–stromal 3D-tissues are reported, which enhance the current understanding of the interactions between cancer cells and fibroblasts and characterize the influence on the secretion of extracellular matrix (ECM). The 3D-pancreatic cancer tissues display a decrease in molecular permeability with increasing secretion of ECM proteins through cancer–stromal cell interactions.
- Bioresorbable Fe–Mn and Fe–Mn–HA Materials for Orthopedic Implantation: Enhancing Degradation through Porosity Control
Michael Heiden, Eric Nauman and Lia Stanciu
Version of Record online: 27 APR 2017 | DOI: 10.1002/adhm.201700120
A significant problem with permanent implants is long-term complications and second surgeries. Here, the authors construct resorbable, iron–manganese–hydroxyapatite biocomposites that demonstrate high degradability. The development of a second Ca2Mn7O14 phase, paired with tailorable porosity generated by NaCl-leaching facilitates enhanced apatite layer formation, mouse bone marrow mesenchymal stem cell attachment, reduction of detrimental oxide layer flaking, and more clinically ideal degradation rates.
- Arginine-Rich Peptide-Based mRNA Nanocomplexes Efficiently Instigate Cytotoxic T Cell Immunity Dependent on the Amphipathic Organization of the Peptide
Vimal K. Udhayakumar, Ans De Beuckelaer, Joanne McCaffrey, Cian M. McCrudden, Jonathan L. Kirschman, Daryll Vanover, Lien Van Hoecke, Kenny Roose, Kim Deswarte, Bruno G. De Geest, Stefan Lienenklaus, Philip J. Santangelo, Johan Grooten, Helen O. McCarthy and Stefaan De Koker
Version of Record online: 24 APR 2017 | DOI: 10.1002/adhm.201601412
T-cell immunity elicited by mRNA vaccines is heavily influenced by the delivery system. Cell penetrating peptide containing amphipathic RALA motifs condenses mRNA into nanocomplexes that efficiently translocate their mRNA cargo from endocytic vesicles to the cytosol. Through unique immune activation and enhanced expression, nucleoside modified mRNA complexed with RALA peptide induces potent antigen specific cytolytic T cells in vivo.
- Multilayer Nanofilms via Inkjet Printing for Stabilizing Growth Factor and Designing Desired Cell Developments
Moonhyun Choi, Hee Ho Park, Daheui Choi, Uiyoung Han, Tai Hyun Park, Hwankyu Lee, Juhyun Park and Jinkee Hong
Version of Record online: 24 APR 2017 | DOI: 10.1002/adhm.201700216
Nanofilm incorporating basic fibroblast growth factors (bFGFs) are fabricated using inkjet printing and layer-by-layer assembly. During fabrication process, activity of bFGFs is highly stabilized by mixture of glycerol and water (3:7). The bFGFs released from nanofilm have an effect on a various kinds of cells, such as proliferation of human dermal fibroblast or differentiation of induced pluripotent stem cell.
- Modulation of Heterotypic and Homotypic Cell–Cell Interactions via Zwitterionic Lipid Masks
Matthew Park, Wongu Youn, Doyeon Kim, Eun Hyea Ko, Beom Jin Kim, Sung Min Kang, Kyungtae Kang and Insung S. Choi
Version of Record online: 21 APR 2017 | DOI: 10.1002/adhm.201700063
Easily removable, cell-repellant masks are developed based on zwitterioinic lipids to spatio-selectively seed cells for the study of cell–cell interactions. Prior fabrication methods have often required restrictive conditions or technically complex procedures, but this lipid-based strategy offers a simple and highly biocompatible means of restricting cell adhesion to specified areas, allowing for studies on heterotypic cocultures and collective migration.