Advanced Healthcare Materials
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Recently Published Articles
- Inhibition of Kupffer Cell Autophagy Abrogates Nanoparticle-Induced Liver Injury
Shasha Zhu, Jiqian Zhang, Li Zhang, Wentao Ma, Na Man, Yiming Liu, Wei Zhou, Jun Lin, Pengfei Wei, Peipei Jin, Yunjiao Zhang, Yi Hu, Erwei Gu, Xianfu Lu, Zhilai Yang, Xuesheng Liu, Li Bai and Longping Wen
Version of Record online: 24 FEB 2017 | DOI: 10.1002/adhm.201601252
Kupffer cells prevent upconversion nanoparticles (UCNs) diffusion to hepatocytes and protect liver from nano-hepatotoxicity. Large dose of UCNs deplete Kupffer cells and escape out of sinusoids to hepatocytes, further induce hepatotoxicity. Inhibiting the autophagy of Kupffer cells promotes cells survival and diminishes the uptake of UCNs by hepatocytes, thereby abrogating the nano-hepatotoxicity.
- A Dual Functional Scaffold Tethered with EGFR Antibody Promotes Neural Stem Cell Retention and Neuronal Differentiation for Spinal Cord Injury Repair
Bai Xu, Yannan Zhao, Zhifeng Xiao, Bin Wang, Hui Liang, Xing Li, Yongxiang Fang, Sufang Han, Xiaoran Li, Caixia Fan and Jianwu Dai
Version of Record online: 24 FEB 2017 | DOI: 10.1002/adhm.201601279
A dual functional collagen scaffold tethered with an epidermal growth factor receptor antibody is fabricated. The dual functional scaffold can simultaneously promote adhesion and neuronal differentiation of neural stem cells after spinal cord injury (SCI), which provides a potential strategy for synchronously improving stem cell retention and differentiation with biomaterials for SCI repair.
- Selectively Inducing Cancer Cell Death by Intracellular Enzyme-Instructed Self-Assembly (EISA) of Dipeptide Derivatives
Jie Li, Junfeng Shi, Jamie E. Medina, Jie Zhou, Xuewen Du, Huaimin Wang, Cuihong Yang, Jianfeng Liu, Zhimou Yang, Daniela M. Dinulescu and Bing Xu
Version of Record online: 24 FEB 2017 | DOI: 10.1002/adhm.201601400
A novel process—enzyme-instructed self-assembly (EISA)—to kill cancer cells selectively is reported. We designed two precursors that became self-assembling molecules upon the catalysis of carboxylesterases (CES)–a type of enzyme overexpressed in cancer cells. By amplifying the enzymatic difference between cancer and normal cells, this work provided a new approach for cancer therapy.
- Spatially Assembled Bilayer Cell Sheets of Stem Cells and Endothelial Cells Using Thermosensitive Hydrogels for Therapeutic Angiogenesis
Indong Jun, Taufiq Ahmad, Seongwoo Bak, Joong-Yup Lee, Eun Mi Kim, Jinkyu Lee, Yu Bin Lee, Hongsoo Jeong, Hojeong Jeon and Heungsoo Shin
Version of Record online: 23 FEB 2017 | DOI: 10.1002/adhm.201601340
Cocultured bilayer cell sheets of human mesenchymal stem cells and human umbilical vein endothelial cells on a cell interactive and thermosensitive hydrogel are developed to investigate the effects of a bilayer cell sheet on in vitro proangiogenic functions and in vivo therapeutic angiogenesis of an ischemic injury in a mouse model.
- In Silico Design of Optimal Dissolution Kinetics of Fe-Doped ZnO Nanoparticles Results in Cancer-Specific Toxicity in a Preclinical Rodent Model
Bella B. Manshian, Suman Pokhrel, Uwe Himmelreich, Kaido Tämm, Lauri Sikk, Alberto Fernández, Robert Rallo, Tarmo Tamm, Lutz Mädler and Stefaan J. Soenen
Version of Record online: 23 FEB 2017 | DOI: 10.1002/adhm.201601379
Computational modeling of Fe-doped ZnO reveals concentration- and Fe-level dependent cancer-specific toxicity. The optimal formulation is confirmed in various coculture models, giving selective cancer cell death and resulted in a significant reduction in tumor growth. The data reveal the strength of bioinformatics tools in designing an optimal toxic-by-design nanoparticle formulation for efficient cancer therapy.