Advanced Healthcare Materials

Cover image for Vol. 7 Issue 1

Editor-in-Chief: Lorna Stimson; Deputy Editors: Uta Goebel, Emily Hu

Online ISSN: 2192-2659

Associated Title(s): Advanced Biosystems, Advanced Functional Materials, Advanced Materials, Advanced Materials Technologies, Advanced Science, Biotechnology Journal, Macromolecular Bioscience, Small

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Recently Published Articles

  1. Superhydrophobic/Superhydrophilic Janus Fabrics Reducing Blood Loss

    Tang Zhu, Junrong Wu, Ning Zhao, Chao Cai, Zhenchao Qian, Fangfang Si, Heng Luo, Jing Guo, Xuan Lai, Longquan Shao and Jian Xu

    Version of Record online: 15 JAN 2018 | DOI: 10.1002/adhm.201701086

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    A simple strategy of integrating the opposite wettability in hemostatic fabrics is proposed. Reduced blood loss, effective bleeding control, and even prolonged survival time are achieved. Many other benefits like relieving the psychological stress, obscuring the wound from infection, and reducing the transmission of infectious blood diseases may be expected.

  2. Physical Properties of Implanted Porous Bioscaffolds Regulate Skin Repair: Focusing on Mechanical and Structural Features

    Shumeng Jiang, Sabrina Cloud Li, Chenyu Huang, Barbara Pui Chan and Yanan Du

    Version of Record online: 15 JAN 2018 | DOI: 10.1002/adhm.201700894

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    Adjustment of bioscaffolds' physical properties is able to improve the therapeutic efficacy of assisted skin repair. This report provides an overview on the current understanding of the four main roles that bioscaffolds play in assisted wound healing and highlights the influence of bioscaffolds' physical properties, especially mechanical and structural features to regulate these four roles and the resulting skin repair.

  3. Nitric Oxide Dependent Degradation of Polyethylene Glycol-Modified Single-Walled Carbon Nanotubes: Implications for Intra-Articular Delivery

    Kunal Bhattacharya, Cristiano Sacchetti, Pedro M. Costa, Jens Sommertune, Birgit D. Brandner, Andrea Magrini, Nicola Rosato, Nunzio Bottini, Massimo Bottini and Bengt Fadeel

    Version of Record online: 15 JAN 2018 | DOI: 10.1002/adhm.201700916

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    Polyethylene glycol modified carbon nanotubes (PNTs) are injected intra-articularly into the knee-joint of C57BL/6 mice and their fate is monitored by using Raman spectroscopy–microscopy. Degradation of PNTs is documented mainly in the chondrocyte-rich cartilage region. Subsequent in vitro experiments confirm nitric oxide-dependent degradation of PNTs in activated murine chondrocytes as well as cell-free, peroxynitrite-mediated degradation of PNTs.

  4. A Multifunctional Micellar Nanoplatform with pH-Triggered Cell Penetration and Nuclear Targeting for Effective Cancer Therapy and Inhibition to Lung Metastasis

    Yuting Jing, Xiang Xiong, Yang Ming, Jingya Zhao, Xing Guo, Guang Yang and Shaobing Zhou

    Version of Record online: 15 JAN 2018 | DOI: 10.1002/adhm.201700974

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    The high cell penetration and nuclear targeting with a multifunctional micellar nanoplatform are successfully realized both in vitro and in vivo through pH-triggered surface charge reversal. The delivered anticancer drug with this nanoplatform displays a highly effective antitumor efficacy and an inhibition to the spontaneous lung metastasis.

  5. Functionalized Nanoparticles Efficiently Enhancing the Targeted Delivery, Tumor Penetration, and Anticancer Activity of 7-Ethyl-10-Hydroxycamptothecin

    Xun Liu, Jingxing Si, Qianzhi Zhang, Qian Huang, Danxia Gu, Hao Yang, Xu Chen, Youqing Shen and Meihua Sui

    Version of Record online: 15 JAN 2018 | DOI: 10.1002/adhm.201701140

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    Cys-Arg-Gly-Asp-Lys (CRGDK)-functionalized PEG2.4K-p(HEMASN38)3K (C-SN38) and nonfunctionalized control (B-SN38) are successfully synthesized and self-assemble into nanoparticles with two distinct particle sizes, 30 and 100 nm. Further investigations indicate that C-SN38 possesses significantly enhanced tumor accumulation, intratumor penetration, and anticancer activity compared with B-SN38 in human tumors overexpressing neuropilin-1. It is demonstrated for the first time that CRGDK functionalization is a promising strategy for improved delivery and efficacy of SN38.

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