Advanced Healthcare Materials

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Recently Published Articles

  1. Additively Manufactured Device for Dynamic Culture of Large Arrays of 3D Tissue Engineered Constructs

    Pedro F. Costa, Dietmar W. Hutmacher, Christina Theodoropoulos, Manuela E. Gomes, Rui L. Reis and Cédryck Vaquette

    Article first published online: 26 FEB 2015 | DOI: 10.1002/adhm.201400591

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    This study demonstrates the utilization of additive manufacturing to simultaneously manufacture a multichamber perfusion culture device and arrays of 3D scaffolds readily enclosed within. Such device enables surface modification, seeding, and culture of cells onto the inner scaffolds. Given its versatility and scalability, the employed methodology may in the future lead to high levels of automation in tissue engineering strategies.

  2. Mild Hyperthermia Enhances Transport of Liposomal Gemcitabine and Improves In Vivo Therapeutic Response

    Dickson K. Kirui, Christian Celia, Roberto Molinaro, Shyam S. Bansal, Donato Cosco, Massimo Fresta, Haifa Shen and Mauro Ferrari

    Article first published online: 26 FEB 2015 | DOI: 10.1002/adhm.201400738

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    This team reports on successful utility of gold nanorod-mediated mild hyperthermia (MHT) therapy to prime tumor microenvironment, improve vascular transport, and enhance delivery, and efficacy of gemcitabine. Combinational treatment leads to a twofold increase in therapeutic efficacy and inhibition of CAPAN-1 tumor growth, which is directly correlated to the increase in intratumor gemcitabine concentration.

  3. Biocompatible Enzymatic Roller Pens for Direct Writing of Biocatalytic Materials: “Do-it-Yourself” Electrochemical Biosensors

    Amay J. Bandodkar, Wenzhao Jia, Julian Ramírez and Joseph Wang

    Article first published online: 26 FEB 2015 | DOI: 10.1002/adhm.201400808

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    A biocompatible enzymatic-ink-based roller pen is described to draw user-defined electrochemical biosensors directly on diverse unconventional surfaces for healthcare, environmental, and defense applications.

  4. A Lysinated Thiophene-Based Semiconductor as a Multifunctional Neural Bioorganic Interface

    Simone Bonetti, Assunta Pistone, Marco Brucale, Saskia Karges, Laura Favaretto, Massimo Zambianchi, Tamara Posati, Anna Sagnella, Marco Caprini, Stefano Toffanin, Roberto Zamboni, Nadia Camaioni, Michele Muccini, Manuela Melucci and Valentina Benfenati

    Article first published online: 26 FEB 2015 | DOI: 10.1002/adhm.201400786

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    A biomodified quaterthiophene semiconductor having lysine-alpha ends, namely T4Lys, is explored as multifunctional organic neural interface. T4Lys exhibits exceptional properties in terms of adhesion and outgrowth of primary neurons without the need of additional coating, combined to fluorescence, electronic transport of the π-conjugated framework as well as humidity-activated ionic conduction. Novel biomodified materials could enable simplified bioelectronic device architecture to interact with neural cells.

  5. Advances in Skin Regeneration: Application of Electrospun Scaffolds

    Mohammad Norouzi, Samaneh Moghadasi Boroujeni, Noushin Omidvarkordshouli and Masoud Soleimani

    Article first published online: 26 FEB 2015 | DOI: 10.1002/adhm.201500001

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    This article reviews the application of biocompatible natural and synthetic polymers, biomolecules (i.e., growth factors and genes) and therapeutic agents (i.e., antibiotics, nanoparticles, and natural medicine) in order to fabricate bioactive electrospun scaffolds as skin substitutes and wound dressings.