Advanced Healthcare Materials
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Recently Published Articles
- Bisphosphonate-Functionalized Imaging Agents, Anti-Tumor Agents and Nanocarriers for Treatment of Bone Cancer
Robin A. Nadar, Nicola Margiotta, Michele Iafisco, Jeroen J. J. P. van den Beucken, Otto C. Boerman and Sander C. G. Leeuwenburgh
Version of Record online: 16 FEB 2017 | DOI: 10.1002/adhm.201601119
Novel bisphosphonate-functionalized imaging and therapeutic agents as well as nanocarriers are being developed for treatment of bone cancer. This review provides an update on the preclinical efficacy of bisphosphonate-functionalized fluorophores, anti-tumor agents and nanocarriers for the treatment of bone metastases.
- Interpenetrating Conducting Hydrogel Materials for Neural Interfacing Electrodes
Josef Goding, Aaron Gilmour, Penny Martens, Laura Poole-Warren and Rylie Green
Version of Record online: 15 FEB 2017 | DOI: 10.1002/adhm.201601177
Hybridization of conducting polymers and hydrogels to form interpenetrating networks can be encouraged and controlled through the functionalization of hydrogel macromers with covalently linked, ionic doping groups. The resultant high-quality conducting hydrogels enable neuroprosthetic devices to use smaller electrodes with greater selectivity, reduced impedance, and lower power consumption compared to traditional metal electrodes.
- Cell Guidance on Nanostructured Metal Based Surfaces
Yulia Zhukova and Ekaterina V. Skorb
Version of Record online: 14 FEB 2017 | DOI: 10.1002/adhm.201600914
Metal surface nanostructuring to guide cell behavior is an attractive strategy to improve parts of medical implants, lab-on-a-chip, soft robotics, self-assembled microdevices, and bionic devices. In the review, we discus important parameters, relevant trends, and specific examples of metal surface nanostructuring to guide cell behavior on metal-based hybrid surfaces, control real-time cells dynamics oscillating stimuli-responsive layer-by-layer polyelectrolyte assemblies.
- Functionalized Polymeric Membrane with Enhanced Mechanical and Biological Properties to Control the Degradation of Magnesium Alloy
Hoi Man Wong, Ying Zhao, Frankie K. L. Leung, Tingfei Xi, Zhixiong Zhang, Yufeng Zheng, Shuilin Wu, Keith D. K. Luk, Kenneth M. C. Cheung, Paul K. Chu and Kelvin W. K. Yeung
Version of Record online: 14 FEB 2017 | DOI: 10.1002/adhm.201601269
Schematic illustrating the effects of the change of the ratio between CO and CO before and after the heat treatment as well as release of Mg on osteoblast adhesion and bone formation: (a) Before the heat treatment, cell spreading of osteoblasts diminished and (b) after the heat treatment, cell spreading on the PCL membrane is enhanced.
- Hematite-Based Photoelectrode Materials for Photoelectrocatalytic Inhibition of Alzheimer's β-Amyloid Self-Assembly
Kayoung Kim, Byung Il Lee, You Jung Chung, Woo Seok Choi and Chan Beum Park
Version of Record online: 14 FEB 2017 | DOI: 10.1002/adhm.201601133
Hematite-based photoelectrode platform effectively inhibits β-amyloid (Aβ) aggregation through photoelectrocatalytic process. Upon illumination under anodic bias, the hematite photoanode generates hole-derived radicals (e.g., hydroxyl radicals, OH·) that trigger the oxidation of Aβ residues, blocking further aggregation. The cobalt phosphate co-catalyst deposited on the hematite photoanode enhances the inhibitory effect of the photoanode on Aβ aggregation.