Advanced Healthcare Materials

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Recently Published Articles

  1. Spatial Control of Cell Gene Expression by siRNA Gradients in Biodegradable Hydrogels

    Michael C. Hill, Minh K. Nguyen, Oju Jeon and Eben Alsberg

    Article first published online: 22 DEC 2014 | DOI: 10.1002/adhm.201400458

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    Short interfering RNA (siRNA) can post-transcriptionally silence cell gene expression, and spatially regulating its presentation to cells may be valuable for engineering complex tissues. Here, a dextran hydrogel is engineered to contain a linear, continuous concentration gradient of siRNA targeting green fluorescent protein (GFP), which induces a spatial gradient of GFP expression in encapsulated cells that persists over time.

  2. Light-Mediated Activation of siRNA Release in Diblock Copolymer Assemblies for Controlled Gene Silencing

    Abbygail A. Foster, Chad T. Greco, Matthew D. Green, Thomas H. Epps III and Millicent O. Sullivan

    Article first published online: 22 DEC 2014 | DOI: 10.1002/adhm.201400671

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    A photocleavable diblock copolymer is used to provide localized cytoplasmic siRNA delivery and light-activated siRNA release. Cellular delivery of siRNA-containing structures indicates stable siRNA association in the absence of a light trigger and effective reduction of target protein expression following irradiation.

  3. A Multifunctional Probe with Aggregation-Induced Emission Characteristics for Selective Fluorescence Imaging and Photodynamic Killing of Bacteria Over Mammalian Cells

    Meng Gao, Qinglian Hu, Guangxue Feng, Nikodem Tomczak, Rongrong Liu, Bengang Xing, Ben Zhong Tang and Bin Liu

    Article first published online: 22 DEC 2014 | DOI: 10.1002/adhm.201400654

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    A multifunctional probe aggregation-induced emission-Zinc(II)-dipicolylamine (AIE-ZnDPA) is developed for selective targeting, fluorescence imaging, and photodynamic killing of both Gram-positive and Gram-negative bacteria over mammalian cells. The probe has significant advantages in simple probe design, enhanced fluorescence upon bacteria binding, excellent photostability, and broad-spectrum antibacterial activity with almost no harm to mammalian cells.

  4. Targeting and Microenvironment-Responsive Lipid Nanocarrier for the Enhancement of Tumor Cell Recognition and Therapeutic Efficiency

    Wei Gao, Tingting Meng, Nianqiu Shi, Hongmeng Zhuang, Zhenzhen Yang and Xianrong Qi

    Article first published online: 17 DEC 2014 | DOI: 10.1002/adhm.201400675

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    Folic acid and tumor microenvironment-sensitive polypeptide (TMSP) co-modified lipid-nanocarrier (F/TMSP-NLC) are successfully formulated in response to the overexpression of folate receptor and the upregulation of matrix metalloproteinase-2 (MMP-2) in tumor microenvironment. The present nanocarrier modified with both TMSP and folic acid is a potential drug delivery system for tumor cell recognition and therapy.

  5. Laser 3D Printing with Sub-Microscale Resolution of Porous Elastomeric Scaffolds for Supporting Human Bone Stem Cells

    Peter E. Petrochenko, Jan Torgersen, Peter Gruber, Lucas A. Hicks, Jiwen Zheng, Girish Kumar, Roger J. Narayan, Peter L. Goering, Robert Liska, Jürgen Stampfl and Aleksandr Ovsianikov

    Article first published online: 17 DEC 2014 | DOI: 10.1002/adhm.201400442

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    Fabrication of scaffolds by two-photon polymerization (2PP) of a biodegradable urethane and acrylate-based photoelastomer is demonstrated. This material supports 2PP processing with sub-micrometer spatial resolution. The high photoreactivity of the biophoto­elastomer permits 2PP processing at a scanning speed of 1000 mm s−1, facilitating rapid fabrication of large structures (>5 mm3). Stable scaffolds with porosities of greater than 60% can be produced using 2PP.