Advanced Healthcare Materials

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  1. You have free access to this content
    Stem Cells: Supramolecular Hydrogels for Long-Term Bioengineered Stem Cell Therapy (Adv. Healthcare Mater. 2/2015) (page 324)

    Junseok Yeom, Su Jin Kim, Hyuntae Jung, Hong Namkoong, Jeonga Yang, Byung Woo Hwang, Kyunghoon Oh, Kimoon Kim, Young Chul Sung and Sei Kwang Hahn

    Article first published online: 28 JAN 2015 | DOI: 10.1002/adhm.201570014

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    K. Kim, Y. C. Sung, S. K. Hahn, and co-workers develop supramolecular hydrogels for long-term engineered mesenchymal stem cell (eMSC) therapy using the host-guest chemistry of cucurbit[6]uril and diaminohexane on page 237. The eMSCs can produce enhanced green fluorescence protein within the hydrogels in mice for more than 60 days. This platform technology is successfully applied to the treatment of cancer, reflecting the feasibility for various cell therapy and tissue engineering.

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    Self-Healing Materials: Autonomic Healing of Acrylic Bone Cement (Adv. Healthcare Mater. 2/2015) (page 170)

    A. Sydney Gladman, Asha-Dee N. Celestine, Nancy R. Sottos and Scott R. White

    Article first published online: 28 JAN 2015 | DOI: 10.1002/adhm.201570009

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    Inspired by damage repair in biological systems, S. R. White and team demonstrate a novel self-healing system in a non-living commercial biomaterial on page 202. This self-healing acrylic bone cement is enabled by solvent-filled microcapsules, which heal crack damage and restore up to 80% of the initial fracture toughness of the cement. This innovation has major implications for extending the lifetime of orthopedic joint replacements.

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    Masthead: (Adv. Healthcare Mater. 2/2015)

    Article first published online: 28 JAN 2015 | DOI: 10.1002/adhm.201570013

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    Micropatterning: Activated-Ester-Type Photocleavable Crosslinker for Preparation of Photodegradable Hydrogels Using a Two-Component Mixing Reaction (Adv. Healthcare Mater. 2/2015) (page 245)

    Fumiki Yanagawa, Shinji Sugiura, Toshiyuki Takagi, Kimio Sumaru, Gulden Camci-Unal, Alpesh Patel, Ali Khademhosseini and Toshiyuki Kanamori

    Article first published online: 28 JAN 2015 | DOI: 10.1002/adhm.201570012

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    On page 246 S. Sugiura and co-workers report a novel crosslinker, namely activated-ester-type photocleavable crosslinker, to prepare photodegradable hydrogels. The photocleavable crosslinker is a potentially convenient material for preparing photodegradable hydrogels with biocompatible polymers containing amino moieties (amino-terminated tetra-arm poly(ethylene glycol) or gelatin.

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    Hydrogels: Glacier Moraine Formation-Mimicking Colloidal Particle Assembly in Microchanneled, Bioactive Hydrogel for Guided Vascular Network Construction (Adv. Healthcare Mater. 2/2015) (page 169)

    Min Kyung Lee, Max H. Rich, Artem Shkumatov, Jae Hyun Jeong, Marni D. Boppart, Rashid Bashir, Martha U. Gillette, Jonghwi Lee and Hyunjoon Kong

    Article first published online: 28 JAN 2015 | DOI: 10.1002/adhm.201570008

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    On page 195 J. Lee, H. J. Kong, and colleagues demonstrate a new method to align microparticles releasing bioactive molecules in microchannels of a hydrogel, allowing the guiding of growth direction and spacing of vascular networks.

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