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Recently Published Articles

  1. Osteogenic/Angiogenic Dual Growth Factor Delivery Microcapsules for Regeneration of Vascularized Bone Tissue

    Ramesh Subbiah, Mintai Peter Hwang, Se Young Van, Sun Hee Do, Hansoo Park, Kangwon Lee, Sang Heon Kim, Kyusik Yun and Kwideok Park

    Article first published online: 2 JUL 2015 | DOI: 10.1002/adhm.201500341

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    A novel dual growth factor delivery system composed of bone morphogenetic protein (BMP-2)-loaded poly(lactic-co-glycolic acid) (PLGA) NPs and vascular endothelial growth factor (VEGF)-encapsulated alginate microcapsule (MC) proves a synergistic effect of osteogenic differentiation of umbilical cord blood-derived mesenchymal stem cells (UCB-MSC) on 2D and 3D environment in vitro and vascularized bone formation using a rat calvarial bone defect model in vivo.

  2. Biofabricated Nanoparticle Coating for Liver-Cell Targeting

    Cheng Zhang, Xue Qu, Jinyang Li, Hua Hong, Jianbo Li, Jie Ren, Gregory F. Payne and Changsheng Liu

    Article first published online: 2 JUL 2015 | DOI: 10.1002/adhm.201500202

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    Biology often uses noncovalent interactions to create responsive structures and confer complex functions (e.g., molecular recognition). Using biology as a source of materials and inspiration, a responsive nanoparticle coating is self-assembled with terminal galactomannan residues to confer liver-cell targeting function.

  3. Nanofibrous Spongy Microspheres Enhance Odontogenic Differentiation of Human Dental Pulp Stem Cells

    Rong Kuang, Zhanpeng Zhang, Xiaobing Jin, Jiang Hu, Melanie J. Gupte, Longxing Ni and Peter X. Ma

    Article first published online: 2 JUL 2015 | DOI: 10.1002/adhm.201500308

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    Nanofibrous spongy microspheres (NF-SMS) are developed for dentin regeneration. NF-SMS enhance the proliferation and odontogenic differentiation of human dental pulp stem cells, compared to nanofibrous microspheres without micropores and conventional solid microspheres with neither nanofibers nor pores. NF-SMS also enhance dentin matrix deposition in vivo, demonstrating great potential as an injectable cell carrier for dentin regeneration.

  4. 3D Cardiac Microtissues Encapsulated with the Co-Culture of Cardiomyocytes and Cardiac Fibroblasts

    Harpinder Saini, Ali Navaei, Alison Van Putten and Mehdi Nikkhah

    Article first published online: 30 JUN 2015 | DOI: 10.1002/adhm.201500331

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    3D cardiac microtissues embedded with the co-culture of cardiomyocytes and cardiac fibroblasts are engineered. The findings demonstrate that the cell–cell ratio, and the construct size are among the crucial parameters which need to be optimized to enhance the functionalities of the engineered microtissues.

  5. Synthesis of Carbohydrate Capped Silicon Nanoparticles and their Reduced Cytotoxicity, In Vivo Toxicity, and Cellular Uptake

    Jayshree H. Ahire, Mehrnaz Behray, Carl A. Webster, Qi Wang, Victoria Sherwood, Nattika Saengkrit, Uracha Ruktanonchai, Noppawan Woramongkolchai and Yimin Chao

    Article first published online: 29 JUN 2015 | DOI: 10.1002/adhm.201500298

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    Carbohydrate capped silicon nanoparticles including galactose, glucose, mannose, and lactose are successfully developed as targeting and monitoring agent for drug delivery. They show reduced toxicity both in vitro and in vivo compared to amine terminated silicon nanoparticles, and can be taken up more readily by cancerous cells than noncancerous cells.