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Recently Published Articles

  1. Skin Diseases Modeling using Combined Tissue Engineering and Microfluidic Technologies

    Mohammad Hossein Mohammadi, Behnaz Heidary Araghi, Vahid Beydaghi, Armin Geraili, Farshid Moradi, Parya Jafari, Mohsen Janmaleki, Karol Papera Valente, Mohsen Akbari and Amir Sanati-Nezhad

    Version of Record online: 22 AUG 2016 | DOI: 10.1002/adhm.201600439

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    Tissue engineering and microfluidics have significantly contributed toward engineering of in vitro skin substitutes to test the penetration of chemicals, replace damaged skins and model skin diseases. Organ-on-chip platforms are presenting a novel approach by the integration of microfluidics and biomaterials in order to develop physiologically relevant disease models.

  2. 3D Cell Printing of Functional Skeletal Muscle Constructs Using Skeletal Muscle-Derived Bioink

    Yeong-Jin Choi, Taek Gyoung Kim, Jonghyeon Jeong, Hee-Gyeong Yi, Ji Won Park, Woonbong Hwang and Dong-Woo Cho

    Version of Record online: 16 AUG 2016 | DOI: 10.1002/adhm.201600483

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    Skeletal muscle-derived bioink with 3D cell-printing technology facilitates the fabrication of 3D functional muscle constructs. 3D cell-printing technology can generate various types of constructs and cellular alignments in a controlled manner. The bioink retains the major extracellular matrix molecules that provide a microenvironment similar to that of native muscle and induce myogenesis in 3D cell-printed muscle constructs.

  3. Self-Assembling Doxorubicin Prodrug Forming Nanoparticles and Effectively Reversing Drug Resistance In Vitro and In Vivo

    Xiaoman Mao, Jingxing Si, Qian Huang, Xuanrong Sun, Qianzhi Zhang, Youqing Shen, Jianbin Tang, Xiangrui Liu and Meihua Sui

    Version of Record online: 16 AUG 2016 | DOI: 10.1002/adhm.201600345

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    Amphiphilic PEG2K-DOX prodrug (A) can self-assemble into nanoparticles, which remarkably promote the cellular uptake and subsequent accumulation of doxorubicin in multidrug resistant cancer cell line MCF-7/ADR (B), and significantly improve the pharmacokinetic properties of doxorubicin (C). Eventually, PEG2K-DOX nanoparticles successfully sensitize MCF-7/ADR xenograft tumors to doxorubicin (D).

  4. You have free access to this content
    Masthead: (Adv. Healthcare Mater. 15/2016)

    Version of Record online: 11 AUG 2016 | DOI: 10.1002/adhm.201670081

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    Designed Stem Cell Aggregates: Enhanced Biological Functions of Human Mesenchymal Stem-Cell Aggregates Incorporating E-Cadherin-Modified PLGA Microparticles (Adv. Healthcare Mater. 15/2016) (page 1992)

    Yan Zhang, Hongli Mao, Chao Gao, Suhua Li, Qizhi Shuai, Jianbin Xu, Ke Xu, Lei Cao, Ren Lang, Zhongwei Gu, Toshihiro Akaike and Jun Yang

    Version of Record online: 11 AUG 2016 | DOI: 10.1002/adhm.201670082

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    E-cadherin-modified poly(lactic-co-glycolic acid) (hE-cad-PLGA) microparticles were fabricated and then mediated the 3D cell aggregates of human mesenchymal stem cells (MSCs) on page 1949 by Jun Yang and co-workers. The hE-cad-Fc matrix and the PLGA microparticles synergistically regulate the proliferation and bioactive factors secretions of MSCs by activating EGFR, AKT and ERK1/2 signaling pathways. The hE-cad-PLGA microparticles offer a novel route to expand multipotent stem cell-based clinical applications.