Advanced Healthcare Materials
Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Editor-in-Chief: Lorna Stimson
Online ISSN: 2192-2659
Associated Title(s): Advanced Energy Materials, Advanced Engineering Materials, Advanced Functional Materials, Advanced Materials, Advanced Materials Interfaces, Advanced Optical Materials, Biotechnology Journal, ChemMedChem, Macromolecular Bioscience, Particle & Particle Systems Characterization, Small
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- Targeting and Microenvironment-Responsive Lipid Nanocarrier for the Enhancement of Tumor Cell Recognition and Therapeutic Efficiency
Wei Gao, Tingting Meng, Nianqiu Shi, Hongmeng Zhuang, Zhenzhen Yang and Xianrong Qi
Article first published online: 17 DEC 2014 | DOI: 10.1002/adhm.201400675
Folic acid and tumor microenvironment-sensitive polypeptide (TMSP) co-modified lipid-nanocarrier (F/TMSP-NLC) are successfully formulated in response to the overexpression of folate receptor and the upregulation of matrix metalloproteinase-2 (MMP-2) in tumor microenvironment. The present nanocarrier modified with both TMSP and folic acid is a potential drug delivery system for tumor cell recognition and therapy.
- Laser 3D Printing with Sub-Microscale Resolution of Porous Elastomeric Scaffolds for Supporting Human Bone Stem Cells
Peter E. Petrochenko, Jan Torgersen, Peter Gruber, Lucas A. Hicks, Jiwen Zheng, Girish Kumar, Roger J. Narayan, Peter L. Goering, Robert Liska, Jürgen Stampfl and Aleksandr Ovsianikov
Article first published online: 17 DEC 2014 | DOI: 10.1002/adhm.201400442
Fabrication of scaffolds by two-photon polymerization (2PP) of a biodegradable urethane and acrylate-based photoelastomer is demonstrated. This material supports 2PP processing with sub-micrometer spatial resolution. The high photoreactivity of the biophotoelastomer permits 2PP processing at a scanning speed of 1000 mm s−1, facilitating rapid fabrication of large structures (>5 mm3). Stable scaffolds with porosities of greater than 60% can be produced using 2PP.
- Biomineral Coating Increases Bone Formation by Ex Vivo BMP-7 Gene Therapy in Rapid Prototyped Poly(l-lactic acid) (PLLA) and Poly(ε-caprolactone) (PCL) Porous Scaffolds
Eiji Saito, Darilis Suarez-Gonzalez, William L. Murphy and Scott J. Hollister
Article first published online: 16 DEC 2014 | DOI: 10.1002/adhm.201400424
The combination of indirect solid freeform fabrication (SFF) technique and biomineral coating is applied to create scaffolds from two kinds of base materials, poly (l-lactic acid) (PLLA) and poly (ε-caprolactone) (PCL), with the same architecture, and able to improve in vivo bone ingrowth. The improved bone ingrowth compensates scaffold mechanical loss during its degradation.
- Plasmon-Coupled Gold Nanospheres for Two-Photon Imaging and Photoantibacterial Activity
Peiyan Yuan, Xin Ding, Zhenping Guan, Nengyue Gao, Rizhao Ma, Xiao-Fang Jiang, Yi Yan Yang and Qing-Hua Xu
Article first published online: 15 DEC 2014 | DOI: 10.1002/adhm.201400524
Positively charged Au nanospheres are found to form aggregates on the bacterial surface, resulting in significantly enhanced two-photon photoluminescence (TPPL). The enhanced TPPL is successfully utilized to image bacterial cells in the NIR region. In addition, these Au NSs effectively eradicate the bacterial cells by laser pulses in the same NIR region due to the photothermal effect.
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