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  1. Simultaneously Photo-Cleavable and Activatable Prodrug-Backboned Block Copolymer Micelles for Precise Anticancer Drug Delivery

    Dongfang Zhou, Jinshan Guo, Gloria B. Kim, Jizhen Li, Xuesi Chen, Jian Yang and Yubin Huang

    Version of Record online: 27 JUL 2016 | DOI: 10.1002/adhm.201600470

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    A simultaneously photo-cleavable and activatable prodrug-backboned block copolymer (BCP) micelle strategy is demonstrated. Without light treatment, the micelles stay silent and inactivated, being biocompatible to normal tissues. Concurrent chain cleavage of BCP micelles and the activation of Pt(IV) prodrug could be temporally and spatially triggered by UV or even visible light for precise anticancer drug delivery.

  2. Biomaterials for Metastasis: Bridging the Gap between Basic and Translational Research

    João Conde, Noam Shomron and Natalie Artzi

    Version of Record online: 26 JUL 2016 | DOI: 10.1002/adhm.201600414

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    Cancer therapy has leveraged the progress in biomaterials science to target the primary tumor, giving priority to systemic treatments despite the benefits of local therapies. Herein lies the issue of how to best approach metastasis therapeutics in a focused manner. By outlining the current challenges researchers face, we develop a framework by which to examine the optimal therapeutic approach to forthcoming anti-metastatic nanotherapies.

  3. Synthesis of Self-Assembled Spermidine-Carbon Quantum Dots Effective against Multidrug-Resistant Bacteria

    Yu-Jia Li, Scott G. Harroun, Yu-Chia Su, Chun-Fang Huang, Binesh Unnikrishnan, Han-Jia Lin, Chia-Hua Lin and Chih-Ching Huang

    Version of Record online: 22 JUL 2016 | DOI: 10.1002/adhm.201600297

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    Spermidine, a biogenic polyamine, when self-assembled on carbon quantum dots (CQDs), exhibits >25 000-fold improvement in its antimicrobial activity against multidrug resistant bacteria. Antibacterial wound-healing assays reveal that the spermidine-modified CQDs are an effective dressing nanomaterial for treatment of bacterial infections.

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    3D Bioprinting: 3D Bioprinting Using a Templated Porous Bioink (Adv. Healthcare Mater. 14/2016) (page 1681)

    James P. K. Armstrong, Madeline Burke, Benjamin M. Carter, Sean A. Davis and Adam W. Perriman

    Version of Record online: 20 JUL 2016 | DOI: 10.1002/adhm.201670070

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    A.W. Perriman and co-workers describe a new cell-containing hybrid bio-ink that allows the 3D printing of physiological architectures with templated micropores on page 1724. The printed constructs are then used in cartilage and bone tissue engineering, giving rise to well-distributed extracellular matrix components.

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    Osteoanabolic Implants: Osteoanabolic Implant Materials for Orthopedic Treatment (Adv. Healthcare Mater. 14/2016) (page 1682)

    Yun-Fei Ding, Rachel W. Li, Masaaki Nakai, Trina Majumdar, Dong-Hai Zhang, Mitsuo Niinomi, Nick Birbilis, Paul N. Smith and Xiao-Bo Chen

    Version of Record online: 20 JUL 2016 | DOI: 10.1002/adhm.201670071

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    On page 1740, Xiao-Bo Chen and co-workers report an orthopedic implant material specifically designed for osteoporotic bone fractures. A newl strontium phosphate coating applied to a bone-mimicking low elastic titanium alloy with a comparative Young's modulus to that of natural bone results in upregulating the growth of osteoblasts and downregulating that of osteoclasts. Such a promising osteoanabolic effect reveals a suitability in particular for patients who suffer from low quality bone organism and slow fracture recovery.

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