Advanced Healthcare Materials

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Recently Published Articles

  1. Modular Poly(ethylene glycol) Matrices for the Controlled 3D-Localized Osteogenic Differentiation of Mesenchymal Stem Cells

    Stéphanie Metzger, Philipp S. Lienemann, Chafik Ghayor, Wilfried Weber, Ivan Martin, Franz E. Weber and Martin Ehrbar

    Article first published online: 31 OCT 2014 | DOI: 10.1002/adhm.201400547

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    This strategy for the local 3D differentiation of cells uses a streptavidin linker to immobilize biotinylated growth factors in controlled areas of a poly(ethylene glycol) scaffold. Human mesenchymal stem cells can be locally differentiated towards the osteogenic lineage inside poly(ethylene glycol) by tethering biotinylated bone morphogenetic protein-2 in confined areas.

  2. Rigid and Flexible Organic Electrochemical Transistor Arrays for Monitoring Action Potentials from Electrogenic Cells

    Chunlei Yao, Qianqian Li, Jing Guo, Feng Yan and I-Ming Hsing

    Article first published online: 31 OCT 2014 | DOI: 10.1002/adhm.201400406

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    Rigid and flexible organic electrochemical transistor arrays are successfully implemented for monitoring cardiac action potentials. Excellent signal to noise ratios are achieved with values routinely larger than 4. These devices are promising to be used in both conventional and emerging areas.

  3. Body-Monitoring and Health Supervision by Means of Optical Fiber-Based Sensing Systems in Medical Textiles

    Brit M. Quandt, Lukas J. Scherer, Luciano F. Boesel, Martin Wolf, Gian-Luca Bona and René M. Rossi

    Article first published online: 30 OCT 2014 | DOI: 10.1002/adhm.201400463

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    This Review deals with possibilities in health-care monitoring by means of polymer optical fiber sensing. Fundamentals of optics and different optical fiber sensing techniques are discussed followed by a materials section and the various available noninvasive applications in which optical fibers can be used. The last section includes approaches for textile integration to allow for wearable long-term monitoring systems.

  4. Poly(N-vinylcaprolactam): A Thermoresponsive Macromolecule with Promising Future in Biomedical Field

    Ji Liu, Antoine Debuigne, Christophe Detrembleur and Christine Jérôme

    Article first published online: 29 OCT 2014 | DOI: 10.1002/adhm.201400371

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    Thermo-induced global-coil transition of poly(N-vinylcaprolactam) (PNVCL), well-defined PNVCL-based homopolymer, block copolymer, random copolymer, and brush copolymer via controlled radical polymerization, as well as their corresponding topological self-assembly structures, like micelles, hydrogels, organic/inorganic nanohybrids, functional surface via surface-initiated polymerization; and potential biomedical applications, like cell culture matrix, controlled drug release, tissue engineering, etc.

  5. Flavonoid-Modified Surfaces: Multifunctional Bioactive Biomaterials with Osteopromotive, Anti-Inflammatory, and Anti-Fibrotic Potential

    Alba Córdoba, María Satué, Manuel Gómez-Florit, Margarita Hierro-Oliva, Christiane Petzold, Staale P. Lyngstadaas, María Luisa González-Martín, Marta Monjo and Joana M. Ramis

    Article first published online: 21 OCT 2014 | DOI: 10.1002/adhm.201400587

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    Bioactive Ti surfaces functionalized with flavonoids taxifolin and quercitrin are successfully fabricated. These innovative, simple, cheap, and robust surfaces exhibit osteogenic, osteopromotive, anti-inflammatory, and anti-fibrotic properties with promising applications in implantable bone medical devices. Given the broad range of functionalities of flavonoid compounds (antioxidant, antibacterial, antiviral, etc.), these surfaces could be extended to other biomedical applications.