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Recently Published Articles

  1. Carbohydrate-Conjugated Hollow Oblate Mesoporous Silica Nanoparticles as Nanoantibiotics to Target Mycobacteria

    Nanjing Hao, Xuan Chen, Seaho Jeon and Mingdi Yan

    Article first published online: 9 OCT 2015 | DOI: 10.1002/adhm.201500491

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    Engineering nanomaterials with enhanced antibacterial activities remains a critical and practical challenge. Hollow oblate mesoporous silica nanoparticles (HOMSNs) are synthesized by a simple protocol of ammonia hydrothermal treatment of oblate mesoporous silica nanoparticles prepared using dibenzyl ether as a cosolvent. When conjugated with trehalose as the targeting ligand, the antibiotic-encapsulated HOMSNs exhibit high binding affinity and antibacterial efficacy toward mycobacteria.

  2. Nuclear-Targeting MSNs-Based Drug Delivery System: Global Gene Expression Analysis on the MDR-Overcoming Mechanisms

    Xiaoyu Li, Limin Pan and Jianlin Shi

    Article first published online: 9 OCT 2015 | DOI: 10.1002/adhm.201500548

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    The biological mechanisms of nuclear-targeting mesoporous silica nanoparticles (MSNs)-based DDSs (DOX@NT-MSNs) in overcoming multidrug resistance of cancer cells have been studied. It is interesting to find for the first time that DOX@NT-MSNs down-regulate the expression of apoptosis suppressor genes and inhibit DNA repair process by disturbing the p53 pathway.

  3. Photomediated Reactive Oxygen Species-Generable Nanoparticles for Triggered Release and Endo/Lysosomal Escape of Drug upon Attenuated Single Light Irradiation

    Eun Ha Seo, Chung-Sung Lee and Kun Na

    Article first published online: 9 OCT 2015 | DOI: 10.1002/adhm.201500622

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    Photomediated reactive oxygen species (ROS)-generable nanoparticles (SRNs) incorporated with ROS-generator and scavenger in a single delivery platform is developed. Under attenuated single light irradiation, doxorubicin loaded SRNs (D-SRNs) synergistically exhibit simultaneous triggered drug release and endo/lysosomal escape as well as photodynamic therapy for highly efficient cancer treatment.

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    Alzheimer's Disease: Targeted Magnetic Nanoparticles for Remote Magnetothermal Disruption of Amyloid-β Aggregates (Adv. Healthcare Mater. 14/2015) (page 2049)

    Colleen N. Loynachan, Gabriela Romero, Michael G. Christiansen, Ritchie Chen, Rachel Ellison, Tiernan T. O'Malley, Ulrich P. Froriep, Dominic M. Walsh and Polina Anikeeva

    Article first published online: 7 OCT 2015 | DOI: 10.1002/adhm.201570081

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    On p. 2100, P. Anikeeva and co-workers demonstrate a technique using remotely triggered local heating to disaggregate deposits of the protein Aβ(1–42), which plays an important role in Alzheimer's Disease pathogenesis. The cover image shows neural network (green) overlayed with amyloid beta plaques (red) that are decorated with magnetic nanoparticles (blue). The glow around the blue spheres represents heat dissipation by nanoparticles, which induces disaggregation of the plaques.