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Recently Published Articles

  1. The Effects of Crystal Phase and Particle Morphology of Calcium Phosphates on Proliferation and Differentiation of Human Mesenchymal Stromal Cells

    Charlène Danoux, Daniel Pereira, Nicola Döbelin, Christoph Stähli, Jake Barralet, Clemens van Blitterswijk and Pamela Habibovic

    Version of Record online: 27 MAY 2016 | DOI: 10.1002/adhm.201600184

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    Understanding the relationship between individual properties of crystalline calcium phosphates and a biological response is important for developing effective synthetic bone graft substitutes. The effects of the calcium phosphate crystal phase and particle structure on the behavior of human mesenchymal stromal cells are investigated by precipitating brushite, monetite, and octacalcium phosphate, with brushite and monetite both as needle-shaped and as plate-shaped particles.

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    Masthead: (Adv. Healthcare Mater. 10/2016)

    Version of Record online: 25 MAY 2016 | DOI: 10.1002/adhm.201670050

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    Cancer Immunotherapy: Comprehensive Mechanism Analysis of Mesoporous-Silica-Nanoparticle-Induced Cancer Immunotherapy (Adv. Healthcare Mater. 10/2016) (page 1246)

    Xiupeng Wang, Xia Li, Kazuko Yoshiyuki, Yohei Watanabe, Yu Sogo, Tadao Ohno, Noriko M. Tsuji and Atsuo Ito

    Version of Record online: 25 MAY 2016 | DOI: 10.1002/adhm.201670051

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    A plain mesoporous silica (MS) nanoparticle without any immunomodulatory molecules enhances anti-cancer immunity in vivo. On page 1169, X.P. Wang, N. M. Tsuji, A. Ito and co-workers show that a plain MS nanoparticle promotes both Th1 and Th2 immune responses, and enhances the effector memory of CD4+ and CD8+ T cell populations in the three most important immune organs (bone marrow, lymph node and spleen) of mice.

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    Photothermal Therapy: Highly Selective Photothermal Therapy by a Phenoxylated-Dextran-Functionalized Smart Carbon Nanotube Platform (Adv. Healthcare Mater. 10/2016) (page 1115)

    Seungmin Han, Taeyun Kwon, Jo-Eun Um, Seungjoo Haam and Woo-Jae Kim

    Version of Record online: 25 MAY 2016 | DOI: 10.1002/adhm.201670047

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    Phenoxylated dextran-coated single-walled carbon nanotubes (pD-SWNT) as photothermal agents that selectively target inflammatory macrophages over normal cells by a specific antibody interaction with the dextran are presented by S. Haam, W.-J. Kim, and co-workers on page 1147. This solution to the nonspecific SWNT-targeting problem shows promise for therapeutic applications since it allows destroying inflammatory macrophages upon NIR irradiation, while leaving normal cells unaffected.

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    Intracellular Delivery: Diamond-Nanoneedle-Array-Facilitated Intracellular Delivery and the Potential Influence on Cell Physiology (Adv. Healthcare Mater. 10/2016) (page 1116)

    Xiaoyue Zhu, Muk Fung Yuen, Li Yan, Zhenyu Zhang, Fujin Ai, Yang Yang, Peter K. N. Yu, Guangyu Zhu, Wenjun Zhang and Xianfeng Chen

    Version of Record online: 25 MAY 2016 | DOI: 10.1002/adhm.201670048

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    G. Zhu, W. Zhang, X. Chen, and co-workers show on page 1157 that diamond needle arrays can efficiently deliver biomolecules into living cells. The study paves the way to a wide application of the nanonneedle treatment by systematically investigating the influence of the treatment on metabolic signal pathways.

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