Advanced Healthcare Materials

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Recently Published Articles

  1. From Flab to Fab: Transforming Surgical Waste into an Effective Bioactive Coating Material

    Baiwen Luo, Shaojun Yuan, Selin Ee Min Foo, Marcus Thien Chong Wong, Thiam Chye Lim, Nguan Soon Tan and Cleo Choong

    Article first published online: 26 NOV 2014 | DOI: 10.1002/adhm.201400514

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    Lipoaspirate-derived extracellular matrix (ECM) material, isolated using a purely physical method, is used as a coating material for improving cell–material interactions. This study demonstrates the exploitation of clinical waste material as a useful coating material for tissue engineering and regenerative medicine applications, and is a stepping-stone towards the development of cell-instructive and even patient-specific scaffolds and implants.

  2. Toward Flexible and Wearable Human-Interactive Health-Monitoring Devices

    Kuniharu Takei, Wataru Honda, Shingo Harada, Takayuki Arie and Seiji Akita

    Article first published online: 25 NOV 2014 | DOI: 10.1002/adhm.201400546

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    Several flexible devices toward realizing flexible wearable health-monitoring devices are presented in this Progress Report, including the concept of a “human-interactive” device. Recent advances for flexible health-monitoring sensors are explained and the future outlook is discussed.

  3. Tetracycline Nanoparticles as Antibacterial and Gene-Silencing Agents

    Ulyana Shimanovich, Anat Lipovsky, Dror Eliaz, Sally Zigdon, Tuomas P. J. Knowles, Yeshayahu Nitzan, Shulamit Michaeli and Aharon Gedanken

    Article first published online: 25 NOV 2014 | DOI: 10.1002/adhm.201400631

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    A general approach is described for antibiotic nanoparticles synthesis using high-­intensity ultrasonic waves. The sonochemical method enables the restoration of tetracycline antibiotic activity by converting the antibiotic into densely packed nanoparticle, which can act as a good biocidal agent against TTCL-sensitive and TTCL-resistant bacterial strains, as well as an inducer of gene silencing for Trypanosome brucei parasites.

  4. Molecularly Engineered Self-Assembling Membranes for Cell-Mediated Degradation

    Daniela S. Ferreira, Yi-An Lin, Honggang Cui, Jeffrey A. Hubbell, Rui L. Reis and Helena S. Azevedo

    Article first published online: 21 NOV 2014 | DOI: 10.1002/adhm.201400586

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    Self-assembling membranes, molecularly designed with enzyme-cleavable building blocks (hyaluronan and peptide amphiphiles containing a proteolytic domain) afford cell-mediated degradation and lead to enhanced cellular colonization of the membranes. This concept can be used as a strategy to develop artificial matrices with more biomimetic degradation for tissue engineering applications.

  5. Antimicrobial Polymers

    Anjali Jain, L. Sailaja Duvvuri, Shady Farah, Nurit Beyth, Abraham J. Domb and Wahid Khan

    Article first published online: 19 NOV 2014 | DOI: 10.1002/adhm.201400418

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    Antimicrobial polymers are the materials having the capability to kill/inhibit the growth of microbes on their surface or surrounding environment. Recently, they gained considerable interest for both research and industry applications. In this Review, an overview of different antimicrobial polymers, their mechanism of action, factors affecting antimicrobial activity and application in various fields are given.

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