Functional Living Biointerphases
Anas Saadeddin, Aleixandre Rodrigo-Navarro, Vicente Monedero, Patricia Rico, David Moratal, María Luisa González-Martín, David Navarro, Andrés J. García and Manuel Salmerón-Sánchez
Article first published online: 28 FEB 2013 | DOI: 10.1002/adhm.201200473
Lactococcus lactis is modified to express a fibronectin fragment (FNIII7-10) as a membrane protein. This interphase, based on a living system, can be further exploited to provide spatio-temporal factors to direct cell function at the material interface. This approach establishes a new paradigm in biomaterial surface functionalization for biomedical applications.