Advanced Healthcare Materials

Cover image for Vol. 5 Issue 3

Early View (Online Version of Record published before inclusion in an issue)

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  1. 1 - 45
  1. Full Papers

    1. Gold Nanoparticles Doped with 199Au Atoms and Their Use for Targeted Cancer Imaging by SPECT

      Yongfeng Zhao, Bo Pang, Hannah Luehmann, Lisa Detering, Xuan Yang, Deborah Sultan, Scott Harpstrite, Vijay Sharma, Cathy S. Cutler, Younan Xia and Yongjian Liu

      Article first published online: 10 FEB 2016 | DOI: 10.1002/adhm.201500992

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      Radioactive Au nanoparticles doped with 199Au atoms are conjugated with D-Ala1-peptide T-amide to serve as a CCR5-targeted nanoprobe for the sensitive and specific detection of both triple negative breast cancer and its metastasis in a mouse model by single photon emission computed tomography.

  2. Communications

    1. Modular Assembly Approach to Engineer Geometrically Precise Cardiovascular Tissue

      Benjamin W. Lee, Bohao Liu, Adam Pluchinsky, Nathan Kim, George Eng and Gordana Vunjak-Novakovic

      Article first published online: 10 FEB 2016 | DOI: 10.1002/adhm.201500956

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      This modular assembly approach to microfabricate functional cardiovascular tissue composites enables quantitative assessment of the effects of microarchitecture on cellular function. Cardiac and endothelial modules are micromolded separately, designed to direct cardiomyocyte alignment and anisotropic contraction or vascular network formation. Assembled cardiovascular tissue composites synchronously contract, facilitating the use of this tissue-engineering platform to study structure–function relationships in the heart.

  3. Full Papers

    1. Mannosylation Allows for Synergic (CD44/C-Type Lectin) Uptake of Hyaluronic Acid Nanoparticles in Dendritic Cells, but Only upon Correct Ligand Presentation

      Arianna Gennari, Maria Pelliccia, Roberto Donno, Ian Kimber and Nicola Tirelli

      Article first published online: 10 FEB 2016 | DOI: 10.1002/adhm.201500941

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      Mannosylation allows for a higher and adjuvant-dependent uptake of hyaluronic acid nanoparticles, although the critical receptor of their internalization appears still to be CD44.

  4. Communications

    1. Image-Reversal Soft Lithography: Fabrication of Ultrasensitive Biomolecular Detectors

      Tina Saberi Safaei, Jagotamoy Das, Sahar Sadat Mahshid, Peter M. Aldridge, Edward H. Sargent and Shana O. Kelley

      Article first published online: 10 FEB 2016 | DOI: 10.1002/adhm.201501025

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      Image-reversal soft lithography enables the straightforward fabrication of high-performance biosensors without requiringhigh-resolution photolitography.

  5. Reviews

    1. Biomaterial-Stabilized Soft Tissue Healing for Healing of Critical-Sized Bone Defects: the Masquelet Technique

      Magdalena Tarchala, Edward J. Harvey and Jake Barralet

      Article first published online: 8 FEB 2016 | DOI: 10.1002/adhm.201500793

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      The Masquelet technique is a two-step surgical procedure used to treat critical-sized bone defects. Although clinically effective, the physiology of healing is not well understood and much has yet to be elucidated and optimized. Multiple modifiable factors have been identified and implemented. This review looks at the factors crucial to the success of the Masquelet technique and how we can further optimize them in clinical practice.

  6. Full Papers

    1. In Vivo Host Response and Degradation of Copolymer Scaffolds Functionalized with Nanodiamonds and Bone Morphogenetic Protein 2

      Salwa Suliman, Yang Sun, Torbjorn O. Pedersen, Ying Xue, Joachim Nickel, Thilo Waag, Anna Finne-Wistrand, Doris Steinmüller-Nethl, Anke Krueger, Daniela E. Costea and Kamal Mustafa

      Article first published online: 8 FEB 2016 | DOI: 10.1002/adhm.201500723

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      Functionalizing poly[(l-lactide)-co-(ε-caprolactone)] scaffolds with nanodiamonds and physisorbed BMP-2 accelerates their degradation and promotes osteogenicity while reducing in vivo foreign-body reactions ectopically in Balb/c mice. Nondegradable nanodiamonds are left in the site of implantation after the scaffold degrades with no adverse effects. This new modality of delivering BMP-2 attenuates inflammatory response while lowering the dose promoting its clinical applications.

  7. Communications

    1. Development of 3D Microvascular Networks Within Gelatin Hydrogels Using Thermoresponsive Sacrificial Microfibers

      Jung Bok Lee, Xintong Wang, Shannon Faley, Bradly Baer, Daniel A. Balikov, Hak-Joon Sung and Leon M. Bellan

      Article first published online: 4 FEB 2016 | DOI: 10.1002/adhm.201500792

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      A 3D microvascularized gelatin hydrogel is produced using thermoresponsive sacrificial poly(N-isopropylacrylamide) microfibers. The capillary-like microvascular network allows constant perfusion of media throughout the thick hydrogel, and significantly improves the viability of human neonatal dermal fibroblasts encapsulated within the gel at a high density.

  8. Full Papers

    1. ssDNA Functionalized Nanoceria: A Redox Active Aptaswitch for Biomolecular Recognition

      Gonca Bülbül, Akhtar Hayat and Silvana Andreescu

      Article first published online: 4 FEB 2016 | DOI: 10.1002/adhm.201500705

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      A nanoceria based colorimetric aptaswitch for probing bimolecular recognition events is reported. The method capitalizes on a newly discovered phenomenon involving reversible, target tunable electrostatic and steric repulsion of single-stranded DNA aptamers to the surface of nanoceria. The results demonstrate that redox active nanoceria can be used as a universal platform to quantify biomolecular targets by measuring changes in the redox properties at the nanoparticle surface upon binding of the DNA and its target analyte.

    2. Impaired Neurite Contact Guidance in Ubiquitin Ligase E3a (Ube3a)-Deficient Hippocampal Neurons on Nanostructured Substrates

      I. Tonazzini, S. Meucci, G. M. Van Woerden, Y. Elgersma and M. Cecchini

      Article first published online: 4 FEB 2016 | DOI: 10.1002/adhm.201500815

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      The performance of neurite contact guidance and adhesion signaling is addressed in Ubiquitin ligase E3a (Ube3a)-deficient hippocampal neurons (Angelman syndrome model). By using nanogrooved substrates, impairments in the contact guidance and neurite polarization of Ube3aKO neurons in response to pure topographical signals are demonstrated and this behavior is linked to the impaired activation of focal adhesion pathway.

  9. Communications

    1. pH-Responsive Fe(III)–Gallic Acid Nanoparticles for In Vivo Photoacoustic Imaging-Guided Photothermal Therapy

      Jianfeng Zeng, Ming Cheng, Yong Wang, Ling Wen, Ling Chen, Zhen Li, Yongyou Wu, Mingyuan Gao and Zhifang Chai

      Article first published online: 4 FEB 2016 | DOI: 10.1002/adhm.201500898

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      pH-responsive biocompatible Fe(III)–gallic acid nanoparticles with strong near-infrared absorbance are very stable in mild acidic conditions, but easily decomposed in neutral conditions, which enables the nanoparticles to be stable in a tumor and easily metabolized in other organs, thus providing a safe nanoplatform for in vivo photoacoustic imaging/photothermal therapy theranostic applications.

  10. Full Papers

    1. The Role of Surface Nanotopography and Chemistry on Primary Neutrophil and Macrophage Cellular Responses

      Susan N. Christo, Akash Bachhuka, Kerrilyn R. Diener, Agnieszka Mierczynska, John D. Hayball and Krasimir Vasilev

      Article first published online: 4 FEB 2016 | DOI: 10.1002/adhm.201500845

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      Innate immune effector cells can differentially respond to the controlled surface nanotopography in the range of 16, 38, and 68 nm. Additional overcoating of these surfaces with amine, carboxyl, or methyl group rich chemistries demonstrates that surfaces with hydrophillic anionic overcoated 68 nm gold nanoparticles can modulate neutrophil and macrophage functionality.

    2. Effects of Graphene Quantum Dots on the Self-Renewal and Differentiation of Mesenchymal Stem Cells

      Jichuan Qiu, Deshuai Li, Xiaoning Mou, Jianhua Li, Weibo Guo, Shu Wang, Xin Yu, Baojin Ma, Shan Zhang, Wei Tang, Yuanhua Sang, Pilar Rivera Gil and Hong Liu

      Article first published online: 2 FEB 2016 | DOI: 10.1002/adhm.201500770

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      Interactions between graphene quantum dots (GQDs) and mesenchymal stem cells (MSCs) are investigated in a systematic way. Good fluorescent property of GQDs facilitates the observation of GQDs uptake by MSCs. Within a certain range of concentration, GQDs have no significant influence on self-renewal potential of MSCs, but even promote and enhance their osteogenic and adipogenic differentiation at the level of mRNA and protein expression.

  11. Communications

    1. Particles for Local Delivery of Proteins Using Intra-Articular Route

      Khosrow Khodabandehlou, Shaomin Tian, James C. Luft, Saad A. Khan and Joseph M. DeSimone

      Article first published online: 2 FEB 2016 | DOI: 10.1002/adhm.201500797

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      Designing a vehicle for local delivery of proteins using intra-articular route is an attractive option to minimize the adverse effects associated with systemic exposure and to maximize the efficacy. Slowly dissolving silylated microparticles are designed with specific size and shape that are capable of extending the retention time of a model protein (bovine serum albumin) in the murine knee joint. No cytotoxicity is observed for the reconstituted formulation when tested against synovial fibroblasts and RAW 264.7 macrophages.

    2. Hydrogel with Aligned and Tunable Pore Via “Hot Ice” Template Applies as Bioscaffold

      Hongjian He, Mingyu Liu, Junjie Wei, Ping Chen, Shilong Wang and Qigang Wang

      Article first published online: 1 FEB 2016 | DOI: 10.1002/adhm.201500707

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      An aligned hydrogel with tunable macropore size via hot ice template is described, which exhibits a high porosity, large pore size, easily modified surface, high survival rate as well as a linear arrangement of NIH3T3 cells.

  12. Full Papers

    1. Integration of 3D Printed and Micropatterned Polycaprolactone Scaffolds for Guidance of Oriented Collagenous Tissue Formation In Vivo

      Sophia P. Pilipchuk, Alberto Monje, Yizu Jiao, Jie Hao, Laura Kruger, Colleen L. Flanagan, Scott J. Hollister and William V. Giannobile

      Article first published online: 28 JAN 2016 | DOI: 10.1002/adhm.201500758

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      A novel scaffold design integrating 3D printed and micropatterned components is developed for guidance of osseous and aligned collagenous tissue formation in vivo. Macro- and microscale cues designed to facilitate regeneration of the bone–ligament complex significantly affect cellular alignment, nuclear elongation, and thickness of oriented collagenous tissue formation.

    2. Dual-Targeting Lactoferrin-Conjugated Polymerized Magnetic Polydiacetylene-Assembled Nanocarriers with Self-Responsive Fluorescence/Magnetic Resonance Imaging for In Vivo Brain Tumor Therapy

      Jen-Hung Fang, Tsung-Lang Chiu, Wei-Chen Huang, Yen-Ho Lai, Shang-Hsiu Hu, You-Yin Chen and San-Yuan Chen

      Article first published online: 28 JAN 2016 | DOI: 10.1002/adhm.201500750

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      Polymerized magnetic polydiacetylene nanocarriers (PDNCs) are developed with ultraviolet cross-linkable 10,12-pentacosadiynoic acid (PCDA) micelles embedded with the superparamagnetic iron oxide nanoparticles (SPIOs) for magnetic resonance imaging (MRI) and sustained curcumin (Cur) release. To enhance the blood–brain barrier (BBB)-crossing efficiency and brain tumor therapy, the lactoferrin (Lf)-conjugated PDNCs are synthesized to achieve increased drug accumulation and half-life in the brain tumors, substantially reducing the systemic drug concentrations and side effects.

  13. Communications

    1. Click-Crosslinked Injectable Gelatin Hydrogels

      Sandeep T. Koshy, Rajiv M. Desai, Pascal Joly, Jianyu Li, Rishi K. Bagrodia, Sarah A. Lewin, Neel S. Joshi and David J. Mooney

      Article first published online: 25 JAN 2016 | DOI: 10.1002/adhm.201500757

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      Injectable gelatin hydrogels formed with bioorthogonal click chemistry (ClickGel) are cell-responsive ECM mimics for in vitro and in vivo biomaterials applications. Gelatin polymers with pendant norbornene (GelN) or tetrazine (GelT) groups can quickly and spontaneously crosslink upon mixing, allowing for high viability of encapsulated cells, establishment of 3D elongated cell morphologies, and biodegradation when injected in vivo.

  14. Full Papers

    1. Water-Borne Endovascular Embolics Inspired by the Undersea Adhesive of Marine Sandcastle Worms

      Joshua P. Jones, Monika Sima, Ryan G. O'Hara and Russell J. Stewart

      Article first published online: 25 JAN 2016 | DOI: 10.1002/adhm.201500825

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      High ionic strength embolic coacervates solidify when injected into renal arteries as they equilibrate to physiological ionic strength.

    2. Flexible pH-Sensing Hydrogel Fibers for Epidermal Applications

      Ali Tamayol, Mohsen Akbari, Yael Zilberman, Mattia Comotto, Emal Lesha, Ludovic Serex, Sara Bagherifard, Yu Chen, Guoqing Fu, Shideh Kabiri Ameri, Weitong Ruan, Eric L. Miller, Mehmet R. Dokmeci, Sameer Sonkusale and Ali Khademhosseini

      Article first published online: 22 JAN 2016 | DOI: 10.1002/adhm.201500553

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      PH-responsive hydrogel fibers that can be used for long-term monitoring of epidermal wound condition are generated. PH-responsive dye is loaded into mesoporous microparticles, which are then embedded into hydrogel fibers developed through microfluidic spinning. The fabricated pH-responsive microfibers are flexible and can create conformal contact with skin. Images of the pH-sensing fibers during real-time pH measurement can be captured with a smart phone camera for convenient readout on-site.

  15. Communications

    1. Sensing Conductive Hydrogels for Rapid Detection of Cytokines in Blood

      Dong-Sik Shin, Zimple Matharu, Jungmok You, Christian Siltanen, Tam Vu, Vijay Krishna Raghunathan, Gulnaz Stybayeva, Ashley E. Hill and Alexander Revzin

      Article first published online: 22 JAN 2016 | DOI: 10.1002/adhm.201500571

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      Conducting polymer hydrogel is fabricated atop gold or ITO electrodes and is functionalized with monoclonal antibodies. Binding of interferon-γ molecules causes redox properties of conductive hydrogel to change in a concentration-dependent fashion without the need for washing or sample handling steps. This conductive hydrogel remains functional in a fouling media such as whole blood.

  16. Full Papers

    1. De Novo Design of Skin-Penetrating Peptides for Enhanced Transdermal Delivery of Peptide Drugs

      Stefano Menegatti, Michael Zakrewsky, Sunny Kumar, Joshua Sanchez De Oliveira, John A. Muraski and Samir Mitragotri

      Article first published online: 22 JAN 2016 | DOI: 10.1002/adhm.201500634

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      A computational method is proposed for identifying skin-penetrating peptides (SPPs) enabling transdermal delivery of therapeutics. The method hinges on the identification of peptide sequences capable of interacting with both keratin and the drug of interest. This approach, validated for the delivery of cyclosporine A, represents an effective procedure for the de novo design of SPPs for delivering therapeutic or personal care products.

    2. Targeting Warburg Effect in Cancers with PEGylated Glucose

      Karthikeyan Narayanan, Nandanan Erathodiyil, Began Gopalan, Shiya Chong, Andrew C. A. Wan and Jackie Y. Ying

      Article first published online: 21 JAN 2016 | DOI: 10.1002/adhm.201500613

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      Cancer cells heavily depend on glucose for ATP generation via glycolysis pathway. Dietary glucose restriction serves as a metabolic control of cancer cell metabolism and proliferation. PEGylated glucose treatment of cancer cells blocks the glucose transporters and inhibits the uptake of glucose, leading to metabolic arrest followed by ATP depletion. This starvation leads to apoptosis in the cancer cells.

  17. Reviews

    1. Bedside, Benchtop, and Bioengineering: Physicochemical Imaging Techniques in Biomineralization

      Neil M. Eisenstein, Sophie C. Cox, Richard L. Williams, Sarah A. Stapley and Liam M. Grover

      Article first published online: 20 JAN 2016 | DOI: 10.1002/adhm.201500617

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      Using heterotopic ossification as a model tissue, techniques available to clinicians, basic science researchers, and materials scientists interested in analyzing the structural and chemical properties of mineralized tissue are outlined. The utility of each technique is discussed along with the relevance for researchers attempting to create engineered bone. Novel data from combat related heterotopic ossification is provided.

  18. Full Papers

    1. Clustering Small Dendrimers into Nanoaggregates for Efficient DNA and siRNA Delivery with Minimal Toxicity

      Chongyi Liu, Naimin Shao, Yitong Wang and Yiyun Cheng

      Article first published online: 20 JAN 2016 | DOI: 10.1002/adhm.201500679

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      A facile strategy in the development of efficient and biocompatible gene vectors: Phenylboronic acid-modified low molecular weight dendrimers are clustered into 100 nm nanostructures that enable efficient DNA and siRNA delivery and can disassemble into small dendrimers in acidic conditions with significantly less cytotoxicity.

  19. Communications

    1. Polyanionic Macromolecular Prodrugs of Ribavirin: Antiviral Agents with a Broad Spectrum of Activity

      Tracey M. Hinton, Kaja Zuwala, Celine Deffrasnes, Shawn Todd, Shuning Shi, Glenn A. Marsh, Megan Dearnley, Benjamin M. Wohl, Martin Tolstrup and Alexander N. Zelikin

      Article first published online: 20 JAN 2016 | DOI: 10.1002/adhm.201500841

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      Macromolecular prodrugs are developed as multiarmed agents against diverse viral pathogens. Lead candidates inhibit infectivity and replication of HIV, Ebola, influenza, measles, RSV, etc—thus being broad-spectrum antiviral agents.

  20. Full Papers

    1. Reduced Blood Coagulation on Roll-to-Roll, Shrink-Induced Superhydrophobic Plastics

      Jolie M. Nokes, Ralph Liedert, Monica Y. Kim, Ali Siddiqui, Michael Chu, Eugene K. Lee and Michelle Khine

      Article first published online: 19 JAN 2016 | DOI: 10.1002/adhm.201500697

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      Superhydrophobic surfaces are achieved in a roll-to-roll platform by purely structural modification with no need for postprocessing. The biocompatible superhydrophobic hard plastic prevents water, blood, urine, and saliva from adhering to the surface, and blood slides off with no residue. Blood coagulation is significantly reduced on the superhydrophobic surface compared to flat, and superhydrophobic tubes are easily configured for medical applications.

  21. Communications

    1. Tuning Reaction and Diffusion Mediated Degradation of Enzyme-Sensitive Hydrogels

      Stacey C. Skaalure, Umut Akalp, Franck J. Vernerey and Stephanie J. Bryant

      Article first published online: 19 JAN 2016 | DOI: 10.1002/adhm.201500728

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      Enzyme-sensitive hydrogels are promising for cell encapsulation and tissue engineering, but result in complex spatiotemporal degradation behavior that is characteristic of reaction-diffusion mechanisms. An experimental and theoretical approach is presented to identify dimensionless quantities that serve as a design tool for engineering enzyme-sensitive hydrogels with controlled degradation patterns by tuning the initial hydrogel properties and enzyme kinetics.

    2. Highly Fluorescent and Photostable Polymeric Nanofibers as Scaffolds for Cell Interfacing and Long-Term Tracking

      Hua Jia Diao, Kai Wang, Hong Yan Long, Mingfeng Wang and Sing Yan Chew

      Article first published online: 15 JAN 2016 | DOI: 10.1002/adhm.201500693

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      Highly fluorescent polymeric nanofibers fabricated via electrospinning of PCL-DPP-PCL (photostable polycaprolactones–di(thiophene-2-yl)-diketopyrrolopyrrole–photostable polycaprolactones) and commercial PCL mixture show superior photostability and cytocompatibility for long-term tracking of cell–substrate interaction. As a proof of concept, these PCL-DPP-PCL nanofibers enable clear visualization of intricate cell–substrate interactions such as oligodendrocyte myelination.

  22. Reviews

    1. Micro- and Nanostructured Biomaterials for Sutureless Tissue Repair

      Samuel J. Frost, D. Mawad, J. Hook and Antonio Lauto

      Article first published online: 4 JAN 2016 | DOI: 10.1002/adhm.201500589

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      A critical survey of nanostructured adhesives for tissue repair is presented. The influence of nanotechnology devices on the design of bioadhesives, which are particularly attractive as minimally invasive sealing techniques, is discussed. The overview is focused on laser-activated nanostructured bioadhesives and gives an original perspective of the field.

  23. Full Papers

    1. Highly Disordered Array of Silicon Nanowires: an Effective and Scalable Approach for Performing and Flexible Electrochemical Biosensors

      Luca Maiolo, Davide Polese, Alessandro Pecora, Guglielmo Fortunato, Yosi Shacham-Diamand and Annalisa Convertino

      Article first published online: 30 DEC 2015 | DOI: 10.1002/adhm.201500538

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      Highly disordered array of silicon nanowires (SiNWs) is used to fabricate performing electrochemical biosensors on ultraflexible substrate. This approach is promising for three reasons: first, the system morphology allows high sensing performance; second, the scalable fabrication is suitable for commercial and disposable devices; third, the sensing behavior can be modeled by considering the morphological and surface characteristics over the NW ensemble.

  24. Communications

    1. Fibroblasts Enhance Migration of Human Lung Cancer Cells in a Paper-Based Coculture System

      Gulden Camci-Unal, David Newsome, Brenda K. Eustace and George M. Whitesides

      Article first published online: 30 DEC 2015 | DOI: 10.1002/adhm.201500709

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      A multilayered paper-based platform is used to investigate the interactions between human lung tumor cells and fibroblasts that are isolated from primary patient tumor samples.

  25. Full Papers

    1. pH-Responsive Wormlike Micelles with Sequential Metastasis Targeting Inhibit Lung Metastasis of Breast Cancer

      Xinyu He, Haijun Yu, Xiaoyue Bao, Haiqiang Cao, Qi Yin, Zhiwen Zhang and Yaping Li

      Article first published online: 29 DEC 2015 | DOI: 10.1002/adhm.201500626

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      Cancer metastasis is the main cause for the high mortality in breast cancer patients. Herein, a pH-responsive wormlike micelle loading succinobucol with sequential targeting is first reported with specific targeting abilities to metastases sites and subsequent intracellular pH-stimulus responsive drug release profiles in cancer cells, thereby improving the therapeutic efficacy on inhibiting lung metastasis of breast cancer tumors.

  26. Communications

    1. Mobile Microplates for Morphological Control and Assembly of Individual Neural Cells

      Shotaro Yoshida, Tetsuhiko Teshima, Kaori Kuribayashi-Shigetomi and Shoji Takeuchi

      Article first published online: 29 DEC 2015 | DOI: 10.1002/adhm.201500782

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      A microfabricated device that enables morphological control and assembly of cultured single neural cells is described. Assembly of morphologically controlled single neural cells allows neuroengineers to design in vitro neural circuits with a single-cell resolution. Compared to conventional cell-patterning techniques, the device allows for the highly precise positioning of neural somas and neurites in a reproducible fashion.

  27. Full Papers

    1. Carbon Dots with Intrinsic Theranostic Properties for Bioimaging, Red-Light-Triggered Photodynamic/Photothermal Simultaneous Therapy In Vitro and In Vivo

      Jiechao Ge, Qingyan Jia, Weimin Liu, Minhuan Lan, Bingjiang Zhou, Liang Guo, Hangyue Zhou, Hongyan Zhang, Ying Wang, Ying Gu, Xiangmin Meng and Pengfei Wang

      Article first published online: 23 DEC 2015 | DOI: 10.1002/adhm.201500720

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      Carbon-dots (C-dots) with intrinsic theranostic properties are successfully synthesized by using polythiophene benzoic acid (PBA) as the precursor. The red fluorescence with robust antibleaching and efficient red-light-triggered generation of heat and 1O2 are key properties that enable C-dots to act as cancer theranostic for imaging-guided, photodynamic–photothermal simultaneous therapy.

    2. Dual Role of Mesenchymal Stem Cells Allows for Microvascularized Bone Tissue-Like Environments in PEG Hydrogels

      Ulrich Blache, Stéphanie Metzger, Queralt Vallmajo-Martin, Ivan Martin, Valentin Djonov and Martin Ehrbar

      Article first published online: 22 DEC 2015 | DOI: 10.1002/adhm.201500795

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      3D cocultures of human mesenchymal stem cells (MSCs) and human endothelial cells (ECs) can be directed toward vascularized bone mimicking tissue constructs in synthetic biomimetic poly(ethylene glycol) (PEG)-based matrices. In this microenvironment, MSCs can fulfill two tasks: they a) support the formation of microvascular structures by endothelial cells and b) can be simultaneously osteogenic differentiated.

    3. Design and Control of Nanoconfinement to Achieve Magnetic Resonance Contrast Agents with High Relaxivity

      Kerstin Malzahn, Sandro Ebert, Isabel Schlegel, Oliver Neudert, Manfred Wagner, Gunnar Schütz, Andreas Ide, Farnoosh Roohi, Kerstin Münnemann, Daniel Crespy and Katharina Landfester

      Article first published online: 22 DEC 2015 | DOI: 10.1002/adhm.201500748

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      The nanoconfinement of gadolinium complex provided by its encapsulation in nanocontainers allows for a significant increase of the relaxivity. Both core and shell of the nanocontainers are chemically tailored so that the retention of the complex and its relaxivity can be simultaneously optimized. The obtained nanocontainers are tested successfully in vivo.

    4. High-Resolution Projection Microstereolithography for Patterning of Neovasculature

      Ritu Raman, Basanta Bhaduri, Mustafa Mir, Artem Shkumatov, Min Kyung Lee, Gabriel Popescu, Hyunjoon Kong and Rashid Bashir

      Article first published online: 22 DEC 2015 | DOI: 10.1002/adhm.201500721

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      Projection stereolithographic 3D printing provides an efficient method of patterning cells and biomaterials at physiologically relevant length scales, on the order of single cells. This technology, which enables rapid fabrication of in vitro models of native tissue, has broad applicability in the field of biomedical engineering.

    5. Toward a Molecular Understanding of the Antibacterial Mechanism of Copper-Bearing Titanium Alloys against Staphylococcus aureus

      Mei Li, Zheng Ma, Ye Zhu, Hong Xia, Mengyu Yao, Xiao Chu, Xiaolan Wang, Ke Yang, Mingying Yang, Yu Zhang and Chuanbin Mao

      Article first published online: 22 DEC 2015 | DOI: 10.1002/adhm.201500712

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      Copper ions released from Cu-containing bone implants damage the permeability of bacterial membranes, promote the leakage of the cellular sugars and proteins and the formation of reactive oxygen species, and interfere in gene replication without destroying genome integrity. All of these actions result in the antibacterial effect of the Cu-containing implants.

  28. Communications

    1. A Lysosome-Targeting AIEgen for Autophagy Visualization

      Chris Wai Tung Leung, Zhiming Wang, Engui Zhao, Yuning Hong, Sijie Chen, Ryan Tsz Kin Kwok, Anakin Chun Sing Leung, Rongsen Wen, Bingshi Li, Jacky Wing Yip Lam and Ben Zhong Tang

      Article first published online: 20 DEC 2015 | DOI: 10.1002/adhm.201500674

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      In this work, a morpholine-functionalized aggregation-induced emission luminogen (AIEgen), AIE-LysoY, is reported for lysosomal imaging and autophagy visualization. To attain outstanding imaging contrast, AIE-LysoY is equipped with excited state intramolecular proton transfer (ESIPT) characteristic. AIE-LysoY provides a new platform for lysosome visualization with good biocompatibility, large Stokes shift, superior signal-to-noise ratio, and high photostability.

    2. Bioorthogonal Radiopaque Hydrogel for Endoscopic Delivery and Universal Tissue Marking

      Seonki Hong, Jonathan Carlson, Hakho Lee and Ralph Weissleder

      Article first published online: 20 DEC 2015 | DOI: 10.1002/adhm.201500780

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      A novel dual marking hydrogel system is reported for radiological and laparoscopic localization of lesions. Bioorthogonally crosslinked hydrogel containing both tantalum and India ink can be rapidly formed inside the body after injecting precursors, and stably located for several days as a long-term biocompatible carrier for markers.

  29. Full Papers

    1. 3D Tissue Formation of Unilocular Adipocytes in Hydrogel Microfibers

      Amy Y. Hsiao, Teru Okitsu, Hiroki Teramae and Shoji Takeuchi

      Article first published online: 17 DEC 2015 | DOI: 10.1002/adhm.201500673

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      Adipocytes differentiated from adipose derived stem cells in hydrogel microfibers aggregate densely, form into fiber-shaped constructs, are metabolically active, and exhibit intrinsic unilocular morphologies of adipose tissues. The adipocyte fibers are highly observable, highly handleable, and can be mass produced for various biological studies, high-throughput drug screening and testing, and clinical applications.

    2. Ruthenium-Containing Block Copolymer Assemblies: Red-Light-Responsive Metallopolymers with Tunable Nanostructures for Enhanced Cellular Uptake and Anticancer Phototherapy

      Wen Sun, Maria Parowatkin, Werner Steffen, Hans-Jürgen Butt, Volker Mailänder and Si Wu

      Article first published online: 17 DEC 2015 | DOI: 10.1002/adhm.201500827

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      Self-assembled nanostructures of red-light-responsive Ru(II)-containing block copolymers are used for anticancer photo­therapy. The Ru complexes in the block copolymers are photocleavable and anticancer agents. Red light releases the Ru complexes and generates singlet oxygen in cancer cells. A moderate irradiation dose, which prevents photodamage, is sufficient to inhibit the growth of cancer cells.

    3. A Comprehensive Study of Osteogenic Calcium Phosphate Silicate Cement: Material Characterization and In Vitro/In Vivo Testing

      Tianxing Gong, Zhiqin Wang, Yixi Zhang, Yubiao Zhang, Mingxiao Hou, Xinwei Liu, Yu Wang, Lejun Zhao, N. Dorin Ruse, Tom Troczynski and Urs O. Häfeli

      Article first published online: 16 DEC 2015 | DOI: 10.1002/adhm.201500469

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      Monocalcium phosphate-added calcium phosphate silicate cement's biocompatibility, biodegradation, and osteoconductivity are studied in this research. It is found that this particular bone cement is biocompatible and promotes osteoblast proliferation. In addition, it demonstrates slower biodegradation and better osseointegration than clinically used calcium phosphate cement.

    4. A Smart Antibacterial Surface for the On-Demand Killing and Releasing of Bacteria

      Ting Wei, Qian Yu, Wenjun Zhan and Hong Chen

      Article first published online: 11 DEC 2015 | DOI: 10.1002/adhm.201500700

      Thumbnail image of graphical abstract

      A smart antibacterial surface is developed for the on-demand killing and releasing of bacteria. This platform combines the pH responsivity of grafted poly(methacrylic acid) chains and the enhanced local topographic effects of silicon nanowire arrays to regulate the interactions of modified surfaces with proteins and bacterial cells simply through changes to the environmental pH.

    5. Development of Electrically Conductive Double-Network Hydrogels via One-Step Facile Strategy for Cardiac Tissue Engineering

      Boguang Yang, Fanglian Yao, Tong Hao, Wancai Fang, Lei Ye, Yabin Zhang, Yan Wang, Junjie Li and Changyong Wang

      Article first published online: 2 DEC 2015 | DOI: 10.1002/adhm.201500520

      Thumbnail image of graphical abstract

      A homogeneous electrically conductive double-network hydrogel, containing poly(thiophene-3-acetic acid) (PTAA) network and methacrylated aminated gelatin (MAAG) network, is prepared by a one-step strategy. The hydrogels have good mechanical properties and electrical conductivity. Their swelling behaviors can be modulated via adjusting the ratio of PTAA/MAAG. Moreover, they can improve the proliferation and cardiac differentiation efficiency of brown adipose-derived stem cells.

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