Advanced Healthcare Materials

Cover image for Vol. 4 Issue 3

Early View (Online Version of Record published before inclusion in an issue)


  1. 1 - 68
  1. Communications

    1. Dynamic Nano-Interfaces Enable Harvesting of Functional 3D-Engineered Tissues

      Akihiro Nishiguchi, Michiya Matsusaki, Shigeru Miyagawa, Yoshiki Sawa and Mitsuru Akashi

      Article first published online: 27 FEB 2015 | DOI: 10.1002/adhm.201500065

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      Functional 3D-engineered tissues are successfully harvested from a substrate using stimuli-responsive hydrogel films with dynamic nano-interface. The dynamic wettability control at the interfaces allows cellular detachment, leading to tissue harvesting without serious damage and remaining polymers. This method can be applied to various types of organs and used for tissue transplantation in regenerative medicine.

    2. Microneedle Biosensor for Real-Time Electrical Detection of Nitric Oxide for In Situ Cancer Diagnosis During Endomicroscopy

      Do Hee Keum, Ho Sang Jung, Taejun Wang, Myeong Hwan Shin, Young-Eun Kim, Ki Hean Kim, G-One Ahn and Sei Kwang Hahn

      Article first published online: 27 FEB 2015 | DOI: 10.1002/adhm.201500012

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      A dual-diagnostic system of endom­icroscope and microneedle sensor is developed to demonstrate high-resolution imaging combined with electrical real-time detection of NO released from cancer tissues. The dual-diagnostic system can be a new platform for facile, precise, rapid, and accurate detection of cancers in various biomedical applications.

    3. NIR-Triggered Drug Delivery by Collagen-Mediated Second Harmonic Generation

      Aoune Barhoumi, Borja Salvador-Culla and Daniel S. Kohane

      Article first published online: 27 FEB 2015 | DOI: 10.1002/adhm.201400768

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      Second harmonic generation is a process through which nonlinear materials such as collagen can absorb two photons and scatter one with twice the energy. Collagen upconverts 730 nm (near-IR) to 365 nm (UV) through second harmonic generation, which cleaves a molecule bound to collagen via a UV-sensitive linker.

  2. Full Papers

    1. Additively Manufactured Device for Dynamic Culture of Large Arrays of 3D Tissue Engineered Constructs

      Pedro F. Costa, Dietmar W. Hutmacher, Christina Theodoropoulos, Manuela E. Gomes, Rui L. Reis and Cédryck Vaquette

      Article first published online: 26 FEB 2015 | DOI: 10.1002/adhm.201400591

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      This study demonstrates the utilization of additive manufacturing to simultaneously manufacture a multichamber perfusion culture device and arrays of 3D scaffolds readily enclosed within. Such device enables surface modification, seeding, and culture of cells onto the inner scaffolds. Given its versatility and scalability, the employed methodology may in the future lead to high levels of automation in tissue engineering strategies.

    2. Mild Hyperthermia Enhances Transport of Liposomal Gemcitabine and Improves In Vivo Therapeutic Response

      Dickson K. Kirui, Christian Celia, Roberto Molinaro, Shyam S. Bansal, Donato Cosco, Massimo Fresta, Haifa Shen and Mauro Ferrari

      Article first published online: 26 FEB 2015 | DOI: 10.1002/adhm.201400738

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      This team reports on successful utility of gold nanorod-mediated mild hyperthermia (MHT) therapy to prime tumor microenvironment, improve vascular transport, and enhance delivery, and efficacy of gemcitabine. Combinational treatment leads to a twofold increase in therapeutic efficacy and inhibition of CAPAN-1 tumor growth, which is directly correlated to the increase in intratumor gemcitabine concentration.

    3. Biocompatible Enzymatic Roller Pens for Direct Writing of Biocatalytic Materials: “Do-it-Yourself” Electrochemical Biosensors

      Amay J. Bandodkar, Wenzhao Jia, Julian Ramírez and Joseph Wang

      Article first published online: 26 FEB 2015 | DOI: 10.1002/adhm.201400808

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      A biocompatible enzymatic-ink-based roller pen is described to draw user-defined electrochemical biosensors directly on diverse unconventional surfaces for healthcare, environmental, and defense applications.

    4. A Lysinated Thiophene-Based Semiconductor as a Multifunctional Neural Bioorganic Interface

      Simone Bonetti, Assunta Pistone, Marco Brucale, Saskia Karges, Laura Favaretto, Massimo Zambianchi, Tamara Posati, Anna Sagnella, Marco Caprini, Stefano Toffanin, Roberto Zamboni, Nadia Camaioni, Michele Muccini, Manuela Melucci and Valentina Benfenati

      Article first published online: 26 FEB 2015 | DOI: 10.1002/adhm.201400786

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      A biomodified quaterthiophene semiconductor having lysine-alpha ends, namely T4Lys, is explored as multifunctional organic neural interface. T4Lys exhibits exceptional properties in terms of adhesion and outgrowth of primary neurons without the need of additional coating, combined to fluorescence, electronic transport of the π-conjugated framework as well as humidity-activated ionic conduction. Novel biomodified materials could enable simplified bioelectronic device architecture to interact with neural cells.

  3. Reviews

    1. Advances in Skin Regeneration: Application of Electrospun Scaffolds

      Mohammad Norouzi, Samaneh Moghadasi Boroujeni, Noushin Omidvarkordshouli and Masoud Soleimani

      Article first published online: 26 FEB 2015 | DOI: 10.1002/adhm.201500001

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      This article reviews the application of biocompatible natural and synthetic polymers, biomolecules (i.e., growth factors and genes) and therapeutic agents (i.e., antibiotics, nanoparticles, and natural medicine) in order to fabricate bioactive electrospun scaffolds as skin substitutes and wound dressings.

    2. MEMS: Enabled Drug Delivery Systems

      Angelica Cobo, Roya Sheybani and Ellis Meng

      Article first published online: 20 FEB 2015 | DOI: 10.1002/adhm.201400772

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      This Review presents the use of microelectromechanical systems (MEMS) technologies to produce drug delivery devices and discusses delivery mechanisms, device formats employed, and various biomedical applications. The integration of dosing control systems, examples of commercially available microtechnology-enabled drug delivery devices, remaining challenges, and future outlook are also discussed.

  4. Communications

    1. Tattoo Conductive Polymer Nanosheets for Skin-Contact Applications

      Alessandra Zucca, Christian Cipriani, Sudha, Sergio Tarantino, Davide Ricci, Virgilio Mattoli and Francesco Greco

      Article first published online: 19 FEB 2015 | DOI: 10.1002/adhm.201400761

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      Conductive tattoo nanosheets are fabricated on top of decal transfer paper and transferred on target surfaces as temporary transfer tattoos. Circuits are patterned with ink-jet printing. Tattoo nanosheets are envisioned as unperceivable human–device interfaces because of conformal adhesion to complex surfaces including skin. They are tested as dry electrodes for surface electromyography (sEMG), which permits the control of a robotic hand.

  5. Full Papers

    1. You have free access to this content
      Lipid-Conjugation of Endogenous Neuropeptides: Improved Biotherapy against Human Pancreatic Cancer

      Gopakumar Gopalakrishnan, Sinda Lepetre, Andrei Maksimenko, Simona Mura, Didier Desmaële and Patrick Couvreur

      Article first published online: 18 FEB 2015 | DOI: 10.1002/adhm.201400816

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      Less toxic biotherapeutic drug formulation for combined cancer therapy: Lipid conjugation of the opioid growth factor neuropeptide Met-Enkephalin has shown increased efficacy in human pancreatic cancer treatment. Results suggest that using squalene-conjugated Met-Enkephalin in a combination therapy with reduced doses of Gemcitabine allows one to cut down the use of toxic drugs in cancer patients.

    2. Porous Hyaluronic Acid Hydrogels for Localized Nonviral DNA Delivery in a Diabetic Wound Healing Model

      Talar Tokatlian, Cynthia Cam and Tatiana Segura

      Article first published online: 18 FEB 2015 | DOI: 10.1002/adhm.201400783

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      Porous hydrogel scaffolds promote gene transfer and enhance wound closure in diabetic mice. Compared with nonporous hydrogels which do not degrade and essentially provide a mechanical barrier to closure, 60 and 100 μm porous hydrogels allow significantly faster wound closure. Interestingly, the delivery of pDNA/PEI polyplexes positively promotes granulation tissue formation even when the DNA does not encode for an angiogenic protein.

  6. Communications

    1. Regulation of Cellular Response Pattern to Phosphorus Ion is a New Target for the Design of Tissue-Engineered Blood Vessel

      Wen Chen, Fangjuan Wang, Wen Zeng, Jun Sun, Li Li, Mingcan Yang, Jiansen Sun, Yangxiao Wu, Xiaohui Zhao and Chuhong Zhu

      Article first published online: 18 FEB 2015 | DOI: 10.1002/adhm.201400763

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      Regulation of cellular response pattern to phosphorus ion (PI) is a new target for the design of tissue-engineered materials. Changing cellular response pattern to high PI can maintain monocyte/macrophage survival in TEBV and the signal of increasing PI can be converted by klotho to the adenosine signals through regulating energy metabolism in monocytes/macrophages.

    2. Creeping Proteins in Microporous Structures: Polymer Brush-Assisted Fabrication of 3D Gradients for Tissue Engineering

      Michel Klein Gunnewiek, Andrea Di Luca, Hermannes Z. Bollemaat, Clemens A. van Blitterswijk, G. Julius Vancso, Lorenzo Moroni and Edmondo M. Benetti

      Article first published online: 13 FEB 2015 | DOI: 10.1002/adhm.201400797

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      Coupling of rapid prototyping techniques and surface-confined polymerizations allows the fabrication of 3D multidirectional gradients of biomolecules within microporous scaffolds. The compositional gradients can be tailored by polymer-brush-assisted diffusion of protein solutions. This technique allows spatial control over stem cells manipulation within 3D environments.

  7. Full Papers

    1. Magnetosomes, Biogenic Magnetic Nanomaterials for Brain Molecular Imaging with 17.2 T MRI Scanner

      Sébastien Mériaux, Marianne Boucher, Benjamin Marty, Yoann Lalatonne, Sandra Prévéral, Laurence Motte, Christopher T. Lefèvre, Françoise Geffroy, Franck Lethimonnier, Michel Péan, Daniel Garcia, Géraldine Adryanczyk-Perrier, David Pignol and Nicolas Ginet

      Article first published online: 13 FEB 2015 | DOI: 10.1002/adhm.201400756

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      Compared to a commercially available ferumoxide contrast agent, a very low dose of few picomoles per kilo of magnetosomes, magnetite nanocrystals biomineralized by magnetotactic bacteria, can still be detected in the mouse brain with high field magnetic resonance imaging scanner.

  8. Communications

    1. Mussel-Inspired Gold Hollow Superparticles for Photothermal Therapy

      Ye Tian, Shun Shen, Jiachun Feng, Xingguo Jiang and Wuli Yang

      Article first published online: 11 FEB 2015 | DOI: 10.1002/adhm.201400787

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      Gold hollow superparticles are prepared taking advantage of the dopamine chemistry. The plasmon coupling of the gold nanoparticles makes the superparticles an effective photothermal conversion agent in the photothermal therapy of cancer. Moreover, the mussel-inspired assembly approach could be extremely useful for the transfer of nanomaterial science to realistic technologies.

  9. Full Papers

    1. Coupling Freshly Isolated CD44+ Infrapatellar Fat Pad-Derived Stromal Cells with a TGF-β3 Eluting Cartilage ECM-Derived Scaffold as a Single-Stage Strategy for Promoting Chondrogenesis

      Henrique V. Almeida, Gráinne M. Cunniffe, Tatiana Vinardell, Conor T. Buckley, Fergal J. O'Brien and Daniel J. Kelly

      Article first published online: 6 FEB 2015 | DOI: 10.1002/adhm.201400687

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      The migration, proliferation, and chondrogenic differentiation of adult stem cells depend on the concentration/porosity of cartilage extracellular matrix (ECM) derived scaffolds. Chondrogenesis in vitro is enhanced in scaffolds with larger-sized pores. Furthermore, seeding freshly isolated CD44+ infrapatellar fat pad-derived stromal cells onto such ECM-derived scaffolds leads to the development of a cartilage-like tissue in vivo.

    2. Nanostructured Architectures by Assembling Polysaccharide-Coated BSA Nanoparticles for Biomedical Application

      Zhenming Wang, Kefeng Wang, Xiong Lu, Chen Li, Lu Han, Chaoming Xie, Yaling Liu, Shuxin Qu and Guanming Zhen

      Article first published online: 5 FEB 2015 | DOI: 10.1002/adhm.201400684

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      The preparation of BMP-2 loaded cationic nanoparticles (CBNPs) and vancomycin (Van) loaded anionic nanoparticles (OCBNPs) is presented. The CBNPs and OCBNPs are assembled on Ti surfaces to construct nanostructured architectures via electrostatic and covalent interactions. BMSCs culture tests confirm that the nanostructured architectures facilitate attachment, proliferation, and differentiation of cells.

  10. Reviews

    1. Cartilage Tissue Engineering: Recent Advances and Perspectives from Gene Regulation/Therapy

      Kuei-Chang Li and Yu-Chen Hu

      Article first published online: 5 FEB 2015 | DOI: 10.1002/adhm.201400773

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      Successful cartilage engineering is dictated by intricate coordination of scaffolds, cells, biological signals, and physical/mechanical factors. In particular, gene therapy in combination with cell therapy offers a promising solution to cartilage repair. This article not only reviews the four pillars of cartilage engineering, but also focuses on the cartilage repair from the perspectives of gene therapy.

  11. Full Papers

    1. Magnetically Targeted Nanocapsules for PAA-Cisplatin-Conjugated Cores in PVA/SPIO Shells via Surfactant-Free Emulsion for Reduced Nephrotoxicity and Enhanced Lung Cancer Therapy

      Chih-Sheng Chiang, Yi-Hsuan Tseng, Bang-Jie Liao and San Yuan Chen

      Article first published online: 5 FEB 2015 | DOI: 10.1002/adhm.201400794

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      Magnetic cis-diamminedichloroplatinum-encapsulated nanocapsules (CDDP-PAA-NCs) synthesized via surfactant-free emulsion to conceal the polyacrylic acid -CDDP complex in the core of polyvinyl alcohol/superparamagnetic iron oxide. The nanocapsules display high loading efficiency and significantly increase the blood circulation time of CDDP in vivo. With magnetic targeting, the CDDP-PAA-NCs can achieve efficacious therapy with negligible side effects.

  12. Communications

    1. Surface Charge Regulation of Osteogenic Differentiation of Mesenchymal Stem Cell on Polarized Ferroelectric Crystal Substrate

      Jianhua Li, Xiaoning Mou, Jichuan Qiu, Shu Wang, Dongzhou Wang, Dehui Sun, Weibo Guo, Deshuai Li, Anil Kumar, Xuebin Yang, Aixue Li and Hong Liu

      Article first published online: 5 FEB 2015 | DOI: 10.1002/adhm.201500032

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      Polarized ferroelectric crystal lithium niobate wafers with different cuts are selected to offer differently charged surfaces. By induction of the mesenchymal stem cells differentiation into osteoblasts on different charged surfaces, the specific osteogenic-associated markers are assessed and the results illustrate that the positively charged wafer surface enhances rBMMSCs osteogenic differentiation.

  13. Full Papers

    1. Development of a Cost-Effective and Simple Protocol for Decellularization and Preservation of Human Amniotic Membrane as a Soft Tissue Replacement and Delivery System for Bone Marrow Stromal Cells

      Mazaher Gholipourmalekabadi, Masoud Mozafari, Mohammad Salehi, Amelia Seifalian, Mojgan Bandehpour, Hossein Ghanbarian, Aleksandra M. Urbanska, Marzieh Sameni, Ali Samadikuchaksaraei and Alexander M. Seifalian

      Article first published online: 4 FEB 2015 | DOI: 10.1002/adhm.201400704

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      Human amniotic membrane (HAM) is successfully decellularized by non-enzymatic agents as a cost-effective and simple protocol. The samples are stained with immunohistochemistry (IHC), hematoxylin and eosin, and DAPI (4′,6-diamidino-2-phenylindole) to evaluate histologically the removal of cells from tissue. The results show the fully removal of cells from the tissue, while the extracellular matrix of the HAM remains unchanged.

    2. Targeting Cell Membrane Lipid Rafts by Stoichiometric Functionalization of Gold Nanoparticles with a Sphingolipid-Binding Domain Peptide

      David Paramelle, Daniel Nieves, Benjamin Brun, Rachel S. Kraut and David G. Fernig

      Article first published online: 3 FEB 2015 | DOI: 10.1002/adhm.201400730

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      Lipid raft targeting on live cells membrane is achieved with peptidol and thiolated alkane ethylene glycol ligand-capped gold nanoparticles, stoichiometrically functionalized with a sphingolipid-binding domain peptide (SBD). Real-time photothermal microscopy reveals the dynamics of gold nanoparticles-tagged lipid microdomains. The SBD-nanoparticles allow for non-membrane protein-based tracking of lipid rafts without prior chemical modification of the cells.

    3. pH-Responsive Reversible PEGylation Improves Performance of Antineoplastic Agent

      Diankui Sun, Jianxun Ding, Chunsheng Xiao, Jinjin Chen, Xiuli Zhuang and Xuesi Chen

      Article first published online: 2 FEB 2015 | DOI: 10.1002/adhm.201400736

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      A pH-responsive reversible PEGylated doxorubicin is developed as a promising antitumor drug formulation, which integrates the advantages of PEGylation and acid-sensitivity. Specifically, the prodrug exhibits acid-accelerated drug release, efficient cellular internalization, and proliferation inhibition in vitro, and selective intratrumoral accumulation and excellent tumor suppression with high security in vivo.

  14. Reviews

    1. Spatio-temporal Control of LbL Films for Biomedical Applications: From 2D to 3D

      Claire Monge, Jorge Almodóvar, Thomas Boudou and Catherine Picart

      Article first published online: 27 JAN 2015 | DOI: 10.1002/adhm.201400715

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      The layer-by-layer (LbL) technique allows the engineering of biofunctional surface coatings with tremendous potential for biomedical applications. In this Review, the aims are to highlight the recent progresses in the field of LbL films for biomedical applications and to discuss the various ways to control spatially and temporally the biochemical and mechanical properties of multilayers.

  15. Full Papers

    1. Multimodality Imaging of Coiled-Coil Mediated Self-Assembly in a “Drug-Free” Therapeutic System

      Rui Zhang, Jiyuan Yang, Te-Wei Chu, Jonathan M. Hartley and Jindřich Kopeček

      Article first published online: 21 JAN 2015 | DOI: 10.1002/adhm.201400679

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      A coiled-coil-mediated macromolecular therapeutic is designed to specifically kill non-Hodgkin's lymphoma cells without the aid of a drug or toxin. Two complementary conjugates are consecutively administered and bound to lymphoma B cell surface, resulting in CD20 crosslinking, membrane reorganization, and ultimately cell apoptosis. Multiple fluorescent images demonstrate that two conjugates can recognize and assemble at cancer cell surface in vitro and in vivo.

    2. Traceable Self-Assembly of Laser-Triggered Cyanine-Based Micelle for Synergistic Therapeutic Effect

      Yuan-I Chen, Cheng-Liang Peng, Pei-Chi Lee, Ming-Hsien Tsai, Chun-Yen Lin, Ying-Hsia Shih, Min-Feng Wei, Tsai-Yueh Luo and Ming-Jium Shieh

      Article first published online: 21 JAN 2015 | DOI: 10.1002/adhm.201400729

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      Doxo@Cy-micelle based on the novel amphiphilic copolymer, methoxy poly­(ethylene glycol) (mPEG)-cyanine-poly(ε-caprolactone) (mPEG-Cy-PCL), is simultaneously used for tracking and NIRF image-guided drug delivery. The obtained Doxo@Cy-micelles exhibit the laser-triggered release of Doxo and an excellent synergistic effect for the combined phototherapy and chemotherapy of cancer.

    3. X-Ray Excited Luminescence Chemical Imaging of Bacterial Growth on Surfaces Implanted in Tissue

      Fenglin Wang, Yash Raval, Tzuen-Rong J. Tzeng and Jeffrey N. Anker

      Article first published online: 21 JAN 2015 | DOI: 10.1002/adhm.201400685

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      A pH sensor film is coupled with an X-ray excited scintillator light source in order to image the local acidosis on the sensor film surface during bacterial growth. High spatial resolution pH imaging is achieved through tissue by irradiating the film surface with a narrowly collimated X-ray beam and collecting the luminescence spectrum point-by-point as the sample is moved relative to the beam.

    4. Development of a Cellularly Degradable PEG Hydrogel to Promote Articular Cartilage Extracellular Matrix Deposition

      Balaji V. Sridhar, John L. Brock, Jason S. Silver, Jennifer L. Leight, Mark A. Randolph and Kristi S. Anseth

      Article first published online: 21 JAN 2015 | DOI: 10.1002/adhm.201400695

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      A cell-mediated degradable hydrogel based on peptide- and protein-functionalized poly(ethylene glycol) hydrogels is designed to allow local cell degradation in a manner that promotes wide-spread cartilage extracellular matrix production, which leads to constructs with improved mechanical properties over just 14 d. The approach exploits the synergistic effects of co-culture between mesenchymal stem cells and chondrocytes to facilitate degradation of an MMP-cleavable peptide sequence.

  16. Communications

    1. Trap Effect of Three-dimensional Fibers Network for High Efficient Cancer-Cell Capture

      Lan Ma, Gao Yang, Nü Wang, Pengchao Zhang, Fengyun Guo, Jingxin Meng, Feilong Zhang, Zuojun Hu, Shutao Wang and Yong Zhao

      Article first published online: 21 JAN 2015 | DOI: 10.1002/adhm.201400650

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      Cells are trapped: The 3D fibrous interfaces, including microfibers, nanofibers, and nanofibers/microbeads composite interfaces, are fabricated by electrospinning. After coated with anti-EpCAM, these 3D fibrous interfaces allow cancer cells to be firmly trapped into the networks that show the outstanding capability for cancer cell capture from real blood.

  17. Full Papers

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      Injectable Colloidal Gold for Use in Intrafractional 2D Image-Guided Radiation Therapy

      Rasmus I. Jølck, Jonas S. Rydhög, Anders N. Christensen, Anders E. Hansen, Linda M. Bruun, Henrik Schaarup-Jensen, Asger Stevner von Wenck, Betina Børresen, Annemarie T. Kristensen, Mads H. Clausen, Andreas Kjær, Knut Conradsen, Rasmus Larsen, Per Munck af Rosenschöld and Thomas L. Andresen

      Article first published online: 21 JAN 2015 | DOI: 10.1002/adhm.201400651

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      First liquid fiducial marker for image-guided radiation therapy is visible in both 2D- and 3D X-ray-based imaging. Doping sucrose acetate isobutyrate with poly(N-isopropyl acrylamide)-coated gold nanoparticles results in a liquid fiducial marker (nanogel) with a contrast level >1000 HU. External radiation therapy is delivered by depositing the nanogel intratumorally in a canine patient with spontaneous cancer, providing evidence of the clinical potential of the developed nanogel.

  18. Communications

    1. Collagen Scaffolds Incorporating Coincident Gradations of Instructive Structural and Biochemical Cues for Osteotendinous Junction Engineering

      Steven R. Caliari, Daniel W. Weisgerber, William K. Grier, Ziad Mahmassani, Marni D. Boppart and Brendan A. C. Harley

      Article first published online: 19 JAN 2015 | DOI: 10.1002/adhm.201400809

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      A fully 3D biomaterial containing overlapping gradations of structural, compositional, and biomolecular cues as seen in native orthopedic interfaces is described for the first time. A multi-compartment collagen scaffold is created for engineering tendon-bone junctions connected by a continuous interface that could induce spatially specific MSC differentiation down tenogenic and osteogenic lineages without the use of differentiation media.

  19. Full Papers

    1. Magnetically Labeled Cells with Surface-Modified Fe3O4 Spherical and Rod-Shaped Magnetic Nanoparticles for Tissue Engineering Applications

      Sara Gil, Clara R. Correia and João F. Mano

      Article first published online: 15 JAN 2015 | DOI: 10.1002/adhm.201400611

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      A study of cellular internalization of amino-surface-modified iron oxide nanoparticles of two different shapes (nanospheres or nanorods) is presented. This approach shows promise for cell guidance and homing towards tissue regeneration. Moreover, upon magnetization individually magnetized cells create their own extracellular ­matrix, forming sheet-like constructs.

    2. The Impact of Aspect Ratio on the Biodistribution and Tumor Homing of Rigid Soft-Matter Nanorods

      Sourabh Shukla, Fabian J. Eber, Adithy S. Nagarajan, Nicholas A. DiFranco, Nora Schmidt, Amy M. Wen, Sabine Eiben, Richard M. Twyman, Christina Wege and Nicole F. Steinmetz

      Article first published online: 13 JAN 2015 | DOI: 10.1002/adhm.201400641

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      A bioinspired, bottom-up assembly strategy is used to control the aspect ratio of rigid, soft-matter nanoassemblies derived from tobacco mosaic virus (TMV) components. The aspect ratio can be engineered to tailor biodistribution, longevity, and tumor penetration by the carrier. In combination with molecular recognition chemistry, modulating the aspect ratio is a powerful tool for the development of nanomedicines.

  20. Communications

    1. Radiofrequency Ablation of Drug-Resistant Cancer Cells Using Molecularly Targeted Carboxyl-Functionalized Biodegradable Graphene

      Abhilash Sasidharan, Amal J. Sivaram, Archana P. Retnakumari, Parwathy Chandran, Giridharan Loghanathan Malarvizhi, Shantikumar Nair and Manzoor Koyakutty

      Article first published online: 13 JAN 2015 | DOI: 10.1002/adhm.201400670

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      Under ultralow radiofrequency (RF) power, transferrin-conjugated graphene nanoparticles can thermally ablate drug- or radiation-resistant cancer cells very effectively. The results suggest that graphene-based RF hyperthermia can be an efficient method to manage drug-/radiation-resistant cancers.

  21. Full Papers

    1. γ-PGA-Coated Mesoporous Silica Nanoparticles with Covalently Attached Prodrugs for Enhanced Cellular Uptake and Intracellular GSH-Responsive Release

      Xin Du, Lin Xiong, Sheng Dai and Shi Zhang Qiao

      Article first published online: 12 JAN 2015 | DOI: 10.1002/adhm.201400726

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      An intracellular GSH (glutathione)-responsive mesoporous silica nanoparticles (MSNs)-based drug delivery system is developed by disulfide-bond grafting of anticancer drug in the MSNs interior for GSH-triggered drug release in the cytoplasm and the subsequent electrostatic adsorption of poly (γ-glutamic acid) on MSNs surface for γ-glutamyl transpeptidase-mediated endocytosis to enhance cellular uptake capability.

  22. Essays

    1. Going Beyond Compromises in Multifunctionality of Biomaterials

      Axel T. Neffe and Andreas Lendlein

      Article first published online: 28 DEC 2014 | DOI: 10.1002/adhm.201400724

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      Prioritizing one function in biomaterial and biomedical device design goes hand in hand with compromises with respect to other functions. Strategies to overcome the limitations of such an approach for realizing novel fields of biomaterial application are critically evaluated to promote interdisciplinary and integrative research.

  23. Full Papers

    1. Spatial Control of Cell Gene Expression by siRNA Gradients in Biodegradable Hydrogels

      Michael C. Hill, Minh K. Nguyen, Oju Jeon and Eben Alsberg

      Article first published online: 22 DEC 2014 | DOI: 10.1002/adhm.201400458

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      Short interfering RNA (siRNA) can post-transcriptionally silence cell gene expression, and spatially regulating its presentation to cells may be valuable for engineering complex tissues. Here, a dextran hydrogel is engineered to contain a linear, continuous concentration gradient of siRNA targeting green fluorescent protein (GFP), which induces a spatial gradient of GFP expression in encapsulated cells that persists over time.

    2. Light-Mediated Activation of siRNA Release in Diblock Copolymer Assemblies for Controlled Gene Silencing

      Abbygail A. Foster, Chad T. Greco, Matthew D. Green, Thomas H. Epps III and Millicent O. Sullivan

      Article first published online: 22 DEC 2014 | DOI: 10.1002/adhm.201400671

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      A photocleavable diblock copolymer is used to provide localized cytoplasmic siRNA delivery and light-activated siRNA release. Cellular delivery of siRNA-containing structures indicates stable siRNA association in the absence of a light trigger and effective reduction of target protein expression following irradiation.

  24. Communications

    1. A Multifunctional Probe with Aggregation-Induced Emission Characteristics for Selective Fluorescence Imaging and Photodynamic Killing of Bacteria Over Mammalian Cells

      Meng Gao, Qinglian Hu, Guangxue Feng, Nikodem Tomczak, Rongrong Liu, Bengang Xing, Ben Zhong Tang and Bin Liu

      Article first published online: 22 DEC 2014 | DOI: 10.1002/adhm.201400654

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      A multifunctional probe aggregation-induced emission-Zinc(II)-dipicolylamine (AIE-ZnDPA) is developed for selective targeting, fluorescence imaging, and photodynamic killing of both Gram-positive and Gram-negative bacteria over mammalian cells. The probe has significant advantages in simple probe design, enhanced fluorescence upon bacteria binding, excellent photostability, and broad-spectrum antibacterial activity with almost no harm to mammalian cells.

  25. Full Papers

    1. Targeting and Microenvironment-Responsive Lipid Nanocarrier for the Enhancement of Tumor Cell Recognition and Therapeutic Efficiency

      Wei Gao, Tingting Meng, Nianqiu Shi, Hongmeng Zhuang, Zhenzhen Yang and Xianrong Qi

      Article first published online: 17 DEC 2014 | DOI: 10.1002/adhm.201400675

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      Folic acid and tumor microenvironment-sensitive polypeptide (TMSP) co-modified lipid-nanocarrier (F/TMSP-NLC) are successfully formulated in response to the overexpression of folate receptor and the upregulation of matrix metalloproteinase-2 (MMP-2) in tumor microenvironment. The present nanocarrier modified with both TMSP and folic acid is a potential drug delivery system for tumor cell recognition and therapy.

    2. Laser 3D Printing with Sub-Microscale Resolution of Porous Elastomeric Scaffolds for Supporting Human Bone Stem Cells

      Peter E. Petrochenko, Jan Torgersen, Peter Gruber, Lucas A. Hicks, Jiwen Zheng, Girish Kumar, Roger J. Narayan, Peter L. Goering, Robert Liska, Jürgen Stampfl and Aleksandr Ovsianikov

      Article first published online: 17 DEC 2014 | DOI: 10.1002/adhm.201400442

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      Fabrication of scaffolds by two-photon polymerization (2PP) of a biodegradable urethane and acrylate-based photoelastomer is demonstrated. This material supports 2PP processing with sub-micrometer spatial resolution. The high photoreactivity of the biophoto­elastomer permits 2PP processing at a scanning speed of 1000 mm s−1, facilitating rapid fabrication of large structures (>5 mm3). Stable scaffolds with porosities of greater than 60% can be produced using 2PP.

    3. Biomineral Coating Increases Bone Formation by Ex Vivo BMP-7 Gene Therapy in Rapid Prototyped Poly(l-lactic acid) (PLLA) and Poly(ε-caprolactone) (PCL) Porous Scaffolds

      Eiji Saito, Darilis Suarez-Gonzalez, William L. Murphy and Scott J. Hollister

      Article first published online: 16 DEC 2014 | DOI: 10.1002/adhm.201400424

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      The combination of indirect solid freeform fabrication (SFF) technique and biomineral coating is applied to create scaffolds from two kinds of base materials, poly (l-lactic acid) (PLLA) and poly (ε-caprolactone) (PCL), with the same architecture, and able to improve in vivo bone ingrowth. The improved bone ingrowth compensates scaffold mechanical loss during its degradation.

  26. Communications

    1. Plasmon-Coupled Gold Nanospheres for Two-Photon Imaging and Photoantibacterial Activity

      Peiyan Yuan, Xin Ding, Zhenping Guan, Nengyue Gao, Rizhao Ma, Xiao-Fang Jiang, Yi Yan Yang and Qing-Hua Xu

      Article first published online: 15 DEC 2014 | DOI: 10.1002/adhm.201400524

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      Positively charged Au nanospheres are found to form aggregates on the bacterial surface, resulting in significantly enhanced two-photon photoluminescence (TPPL). The enhanced TPPL is successfully utilized to image bacterial cells in the NIR region. In addition, these Au NSs effectively eradicate the bacterial cells by laser pulses in the same NIR region due to the photothermal effect.

  27. Full Papers

    1. You have full text access to this OnlineOpen article
      Bacterial Attachment to Polymeric Materials Correlates with Molecular Flexibility and Hydrophilicity

      Olutoba Sanni, Chien-Yi Chang, Daniel G. Anderson, Robert Langer, Martyn C. Davies, Philip M. Williams, Paul Williams, Morgan R. Alexander and Andrew L. Hook

      Article first published online: 9 DEC 2014 | DOI: 10.1002/adhm.201400648

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      The nature of hydrocarbon pendant groups on polyacrylates for maximizing resistance to bacteria is explored, comparing cyclic, aromatic, and linear chemical groups. Bacterial attachment is found to correlate with the combination of molecular rigidity and hydrophobicity for weak amphiphiles. This key observation can readily be used to further develop polymers with resistance to bacterial attachment.

    2. Hydrogen-Bonded Multilayers of Tannic Acid as Mediators of T-Cell Immunity

      Veronika Kozlovskaya, Bing Xue, Weiqi Lei, Lindsey E. Padgett, Hubert M. Tse and Eugenia Kharlampieva

      Article first published online: 9 DEC 2014 | DOI: 10.1002/adhm.201400657

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      Nanothin coatings with antioxidant and immunosuppressive properties capable of modulating both innate and adaptive immune responses are presented. Hydrogen-bonded multilayers of tannic acid with poly(N-vinylpyrrolidone) or poly(N-vinylcaprolactam) efficiently dissipate pro-inflammatory reactive oxygen and nitrogen species, and attenuate the production of pro-inflammatory cytokines by autoreactive CD4+ T cells. These multilayers may provide physical transplant protection and prevent diabetogenic autoreactive T-cell responses.

    3. Development of Functional Poly(amido amine) CXCR4 Antagonists with the Ability to Mobilize Leukocytes and Deliver Nucleic Acids

      Yan Wang, Stuart T. Hazeldine, Jing Li and David Oupický

      Article first published online: 9 DEC 2014 | DOI: 10.1002/adhm.201400608

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      The synthesis of well-defined polymeric inhibitors of CXCR4 chemokine receptor is reported. The polymers inhibit cancer cell invasion, mobilize leukocytes from bone marrow, and deliver genes.

  28. Progress Reports

    1. Flexible Piezoelectric Thin-Film Energy Harvesters and Nanosensors for Biomedical Applications

      Geon-Tae Hwang, Myunghwan Byun, Chang Kyu Jeong and Keon Jae Lee

      Article first published online: 4 DEC 2014 | DOI: 10.1002/adhm.201400642

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      Inorganic-based flexible piezoelectric thin films offer developments of high-performance flexible energy harvesters and mechanical nanosensors for biomedical applications. This paper provides brief review of flexible piezoelectric thin-film technology for use in biomedical field. The scope includes self-powered flexible piezoelectric harvesting devices, nerves/muscles stimulator, sensitive nano­sensors for detecting of acoustic wave/cellular deformations, and advancement of self-powered flexible biomedical system.

  29. Communications

    1. Ultrastretchable and Flexible Copper Interconnect-Based Smart Patch for Adaptive Thermotherapy

      Aftab M. Hussain, Ernesto Byas Lizardo, Galo A. Torres Sevilla, Joanna M. Nassar and Muhammad M. Hussain

      Article first published online: 3 DEC 2014 | DOI: 10.1002/adhm.201400647

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      Unprecedented 800% stretchable, non-polymeric, widely used, low-cost, naturally rigid, metallic thin-film copper (Cu)-based flexible and non-invasive, spatially tunable, mobile thermal patch with wireless controllability, adaptability (tunes the amount of heat based on the temperature of the swollen portion), reusability, and affordability due to low-cost complementary metal oxide semiconductor (CMOS) compatible integration.

  30. Full Papers

    1. Facile Preparation of Doxorubicin-Loaded Upconversion@Polydopamine Nanoplatforms for Simultaneous In Vivo Multimodality Imaging and Chemophotothermal Synergistic Therapy

      Fuyao Liu, Xiuxia He, Zhen Lei, Liang Liu, Junping Zhang, Hongpeng You, Huimao Zhang and Zhenxin Wang

      Article first published online: 3 DEC 2014 | DOI: 10.1002/adhm.201400676

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      NaGdF4:Yb3+,Er3+@NaGdF4 upconverting nanoparticle@polydopamine nanocomposites (UCNP@PDA) are synthesized by facile water-in-oil microemulsion method, which can be employed to construct multifunctional nanotheranostics. In vivo experimental results demonstrate that PEGylated upconverting nanoparticle (UCNP) with 5 nm polydopamine (PDA) shell (UCNP@PDA5-PEG) presents strong contrast enhancement effects on subcutaneous colorectal tumor. After loading with doxorubicin (DOX), the UCNP@PDA5-PEG-DOX exhibits highly effective chemophotothermal synergistic therapy on colorectal tumor.

    2. Tropoelastin Incorporation into a Dermal Regeneration Template Promotes Wound Angiogenesis

      Yiwei Wang, Suzanne M. Mithieux, Yvonne Kong, Xue-Qing Wang, Cassandra Chong, Ali Fathi, Fariba Dehghani, Eleni Panas, John Kemnitzer, Robert Daniels, Roy M. Kimble, Peter K. Maitz, Zhe Li and Anthony S. Weiss

      Article first published online: 2 DEC 2014 | DOI: 10.1002/adhm.201400571

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      Human tropoelastin enhances wound vascularization. The effect is seen in large and small animal models. The figure shows live animal imaging and demonstrates increased blood vessel density 2 weeks post-surgery in a mouse wound repair model. Tropoelastin has potential use as a facilitator of wound healing.

  31. Communications

    1. Non-Cell-Adhesive Substrates for Printing of Arrayed Biomaterials

      Eric A. Appel, Benjamin L. Larson, Kathryn M. Luly, Jinseong D. Kim and Robert Langer

      Article first published online: 27 NOV 2014 | DOI: 10.1002/adhm.201400594

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      Cellular microarrays have become extremely useful in expediting the investigation of large libraries of (bio)materials for both in vitro and in vivo biomedical applications. An exceedingly simple strategy is developed for the fabrication of non-cell-adhesive substrates supporting the immobilization of diverse (bio)material features, including both monomeric and polymeric adhesion molecules (e.g., RGD and polylysine), hydrogels, and polymers.

  32. Full Papers

    1. From Flab to Fab: Transforming Surgical Waste into an Effective Bioactive Coating Material

      Baiwen Luo, Shaojun Yuan, Selin Ee Min Foo, Marcus Thien Chong Wong, Thiam Chye Lim, Nguan Soon Tan and Cleo Choong

      Article first published online: 26 NOV 2014 | DOI: 10.1002/adhm.201400514

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      Lipoaspirate-derived extracellular matrix (ECM) material, isolated using a purely physical method, is used as a coating material for improving cell–material interactions. This study demonstrates the exploitation of clinical waste material as a useful coating material for tissue engineering and regenerative medicine applications, and is a stepping-stone towards the development of cell-instructive and even patient-specific scaffolds and implants.

  33. Progress Reports

    1. Toward Flexible and Wearable Human-Interactive Health-Monitoring Devices

      Kuniharu Takei, Wataru Honda, Shingo Harada, Takayuki Arie and Seiji Akita

      Article first published online: 25 NOV 2014 | DOI: 10.1002/adhm.201400546

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      Several flexible devices toward realizing flexible wearable health-monitoring devices are presented in this Progress Report, including the concept of a “human-interactive” device. Recent advances for flexible health-monitoring sensors are explained and the future outlook is discussed.

  34. Full Papers

    1. Tetracycline Nanoparticles as Antibacterial and Gene-Silencing Agents

      Ulyana Shimanovich, Anat Lipovsky, Dror Eliaz, Sally Zigdon, Tuomas P. J. Knowles, Yeshayahu Nitzan, Shulamit Michaeli and Aharon Gedanken

      Article first published online: 25 NOV 2014 | DOI: 10.1002/adhm.201400631

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      A general approach is described for antibiotic nanoparticles synthesis using high-­intensity ultrasonic waves. The sonochemical method enables the restoration of tetracycline antibiotic activity by converting the antibiotic into densely packed nanoparticle, which can act as a good biocidal agent against TTCL-sensitive and TTCL-resistant bacterial strains, as well as an inducer of gene silencing for Trypanosome brucei parasites.

    2. Molecularly Engineered Self-Assembling Membranes for Cell-Mediated Degradation

      Daniela S. Ferreira, Yi-An Lin, Honggang Cui, Jeffrey A. Hubbell, Rui L. Reis and Helena S. Azevedo

      Article first published online: 21 NOV 2014 | DOI: 10.1002/adhm.201400586

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      Self-assembling membranes, molecularly designed with enzyme-cleavable building blocks (hyaluronan and peptide amphiphiles containing a proteolytic domain) afford cell-mediated degradation and lead to enhanced cellular colonization of the membranes. This concept can be used as a strategy to develop artificial matrices with more biomimetic degradation for tissue engineering applications.

  35. Communications

    1. Organic Transdermal Iontophoresis Patch with Built-in Biofuel Cell

      Yudai Ogawa, Koichiro Kato, Takeo Miyake, Kuniaki Nagamine, Takuya Ofuji, Syuhei Yoshino and Matsuhiko Nishizawa

      Article first published online: 17 NOV 2014 | DOI: 10.1002/adhm.201400457

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      A completely organic iontophoresis patch is reported. A built-in biofuel cell is mounted on the patch that generates transdermal iontophoretic administration of compounds into the skin. The amplitude of transdermal current is tuned by integrating a conducting polymer-based stretchable resistor of predetermined resistance.

  36. Reviews

    1. You have free access to this content
      Contact Lens Sensors in Ocular Diagnostics

      Nicholas M. Farandos, Ali K. Yetisen, Michael J. Monteiro, Christopher R. Lowe and Seok Hyun Yun

      Article first published online: 17 NOV 2014 | DOI: 10.1002/adhm.201400504

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      Contact lens sensors have been used as minimally invasive and continuous analytical devices to diagnose glaucoma by measuring intraocular pressure, and diabetes from lachrymal glucose. This Review covers contact lens sensors from concept to market by analyzing detection mechanisms, micro/nanofabrication, powering, readout techniques, and high-volume manufacturing, supplemented by a case study. A market analysis and FDA approval process are also outlined.

  37. Full Papers

    1. Controlling the Dynamics of Cell Transition in Heterogeneous Cultures using Surface Chemistry

      Graham J. Hickman, Robert C. Rees, David J. Boocock, A. Graham Pockley and Carole C. Perry

      Article first published online: 13 NOV 2014 | DOI: 10.1002/adhm.201400525

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      An amino-functionalized tissue culture material, which promotes enrichment of an epithelial phenotype from a cancer cell line containing both epithelial and mesenchymal subpopulations, is described. Transitional events in culture between epithelial and mesenchymal phenotypes are implicated in metastasis, isolation, and transitional control of such subpopulations using functional materials will enhance our understanding of cancer cell growth, differentiation, and invasion.

    2. Boronate Cross-linked ATP- and pH-Responsive Nanogels for Intracellular Delivery of Anticancer Drugs

      Xuejiao Zhang, Katharina Achazi and Rainer Haag

      Article first published online: 12 NOV 2014 | DOI: 10.1002/adhm.201400550

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      A novel adenosine-5′-triphosphate (ATP) and a pH dual-responsive biodegradable dPG nanogel are fabricated by inverse nanoprecipitation for the intracellular delivery and release of anticancer drug. The cross-linkers, boronate ester bonds, are cleavable under organelle acidic conditions and the nanogel is further dissociated in response to a high concentration of ATP in the cytoplasm, inducing a complete release of encapsulated drug payload.

  38. Communications

    1. Hydrogel Design of Experiments Methodology to Optimize Hydrogel for iPSC-NPC Culture

      Jonathan Lam, S. Thomas Carmichael, William E. Lowry and Tatiana Segura

      Article first published online: 5 NOV 2014 | DOI: 10.1002/adhm.201400410

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      Bioactive signals can be incorporated in hydrogels to direct encapsulated cell behavior. Design of experiments methodology methodically varies the signals systematically to determine the individual and combinatorial effects of each factor on cell activity. Using this approach enables the optimization of three ligands concentrations (RGD, YIGSR, IKVAV) for the survival and differentiation of neural progenitor cells.

  39. Full Papers

    1. Modular Poly(ethylene glycol) Matrices for the Controlled 3D-Localized Osteogenic Differentiation of Mesenchymal Stem Cells

      Stéphanie Metzger, Philipp S. Lienemann, Chafik Ghayor, Wilfried Weber, Ivan Martin, Franz E. Weber and Martin Ehrbar

      Article first published online: 31 OCT 2014 | DOI: 10.1002/adhm.201400547

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      This strategy for the local 3D differentiation of cells uses a streptavidin linker to immobilize biotinylated growth factors in controlled areas of a poly(ethylene glycol) scaffold. Human mesenchymal stem cells can be locally differentiated towards the osteogenic lineage inside poly(ethylene glycol) by tethering biotinylated bone morphogenetic protein-2 in confined areas.

  40. Communications

    1. Rigid and Flexible Organic Electrochemical Transistor Arrays for Monitoring Action Potentials from Electrogenic Cells

      Chunlei Yao, Qianqian Li, Jing Guo, Feng Yan and I-Ming Hsing

      Article first published online: 31 OCT 2014 | DOI: 10.1002/adhm.201400406

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      Rigid and flexible organic electrochemical transistor arrays are successfully implemented for monitoring cardiac action potentials. Excellent signal to noise ratios are achieved with values routinely larger than 4. These devices are promising to be used in both conventional and emerging areas.

  41. Full Papers

    1. Flavonoid-Modified Surfaces: Multifunctional Bioactive Biomaterials with Osteopromotive, Anti-Inflammatory, and Anti-Fibrotic Potential

      Alba Córdoba, María Satué, Manuel Gómez-Florit, Margarita Hierro-Oliva, Christiane Petzold, Staale P. Lyngstadaas, María Luisa González-Martín, Marta Monjo and Joana M. Ramis

      Article first published online: 21 OCT 2014 | DOI: 10.1002/adhm.201400587

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      Bioactive Ti surfaces functionalized with flavonoids taxifolin and quercitrin are successfully fabricated. These innovative, simple, cheap, and robust surfaces exhibit osteogenic, osteopromotive, anti-inflammatory, and anti-fibrotic properties with promising applications in implantable bone medical devices. Given the broad range of functionalities of flavonoid compounds (antioxidant, antibacterial, antiviral, etc.), these surfaces could be extended to other biomedical applications.

  42. Communications

    1. CpG-Loaded Multifunctional Cationic Nanohydrogel Particles as Self-Adjuvanting Glycopeptide Antitumor Vaccines

      Sebastian Hartmann, Lutz Nuhn, Björn Palitzsch, Markus Glaffig, Natascha Stergiou, Bastian Gerlitzki, Edgar Schmitt, Horst Kunz and Rudolf Zentel

      Article first published online: 18 OCT 2014 | DOI: 10.1002/adhm.201400460

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      Self-adjuvanting antitumor vaccines by multifunctional cationic ­nanohydrogels loaded with CpG. A conjugate ­consisting of tumor-associated MUC1-glycopeptide B-cell epitope and tetanus toxin ­T-cell epitope P2 was linked to cationic nanogels. Oligonucleotide CpG complexation enhanced toll-like receptor (TLR) stimulated T-cell proliferation and rapid immune activation. This co-delivery promotes induction of specific MUC1-antibodies binding to human breast ­tumor cells without external adjuvant.

    2. Spheroform: Therapeutic Spheroid-Forming Nanotextured Surfaces Inspired by Desert Beetle Physosterna cribripes

      Mihyun Lee, Kisuk Yang, Yong Hwa Hwang, Youngro Byun, Dong Yun Lee, Seung-Woo Cho and Haeshin Lee

      Article first published online: 17 OCT 2014 | DOI: 10.1002/adhm.201400429

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      An approach is presented to create arrays of quasi-spherical microdroplets by surfaces called “spheroform” inspired by micro-/nanostructures found in the back of the Namib desert beetle. Spheroform is fabricated by microarray formation of catecholamine polymers on the superhydrophobic background. Spheroform is able to precisely control spheroid sizes of therapeutic islet cells and mesenchymal stem cells. The therapeutic spheroids exhibits improved biochemical activities.

    3. Photopatterning of Multifunctional Hydrogels to Direct Adult Neural Precursor Cells

      Mikhail V. Tsurkan, Richard Wetzel, Heidi R. Pérez-Hernández, Karolina Chwalek, Anna Kozlova, Uwe Freudenberg, Gerd Kempermann, Yixin Zhang, Andrés F. Lasagni and Carsten Werner

      Article first published online: 16 OCT 2014 | DOI: 10.1002/adhm.201400395

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      Matrix-metalloproteinase and photosensitive peptide units are combined with heparin and poly(ethylene glycol) into a light-sensitive multicomponent hydrogel material. Localized degradation of the hydrogel matrix allows the creation of defined spatial constraints and adhesive patterning for cells grown in culture. Using this matrix system, it is demonstrated that the degree of confinement determines the fate of neural precursor cells in vitro.

  43. Full Papers

    1. Inhibition of Angiogenesis by Antioxidant Micelles

      Masaki Moriyama, Stéphanie Metzger, André J. van der Vlies, Hiroshi Uyama, Martin Ehrbar and Urara Hasegawa

      Article first published online: 11 SEP 2014 | DOI: 10.1002/adhm.201400249

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      Antioxidant micelles having catechol moieties in the core efficiently inhibit angiogenesis by scavenging reactive oxygen species as shown in the human umbilical vein endothelial cells (HUVECs) tube formation and ex ovo chicken chorioallantoic membrane (CAM) assay. These micelles may be useful in anti-angiogenic therapy to treat various diseases such as cancer.


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