Advanced Healthcare Materials

Cover image for Vol. 6 Issue 14

Early View (Online Version of Record published before inclusion in an issue)

Editor-in-Chief: Lorna Stimson; Deputy Editor: Uta Goebel

Online ISSN: 2192-2659

Associated Title(s): Advanced Biosystems, Advanced Functional Materials, Advanced Materials, Advanced Materials Technologies, Advanced Science, Biotechnology Journal, Macromolecular Bioscience, Small

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  1. 1 - 74
  1. Full Papers

    1. Graphene Quantum Dots Downregulate Multiple Multidrug-Resistant Genes via Interacting with Their C-Rich Promoters

      Chao Luo, Yanfang Li, Lijuan Guo, Fangwei Zhang, Hui Liu, Jiali Zhang, Jing Zheng, Jingyan Zhang and Shouwu Guo

      Version of Record online: 27 JUL 2017 | DOI: 10.1002/adhm.201700328

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      Graphene quantum dots (GQDs) downregulate multiple multidrug-resistant (MDR) genes via interacting with C-rich regions of their promoters. The inhibitory ability of the GQDs to MDR genes is validated by reversing doxorubicin resistance of MCF-7/ADR cells.

  2. Communications

    1. Protein Coating of DNA Nanostructures for Enhanced Stability and Immunocompatibility

      Henni Auvinen, Hongbo Zhang, Nonappa, Alisa Kopilow, Elina H. Niemelä, Sami Nummelin, Alexandra Correia, Hélder A. Santos, Veikko Linko and Mauri A. Kostiainen

      Version of Record online: 24 JUL 2017 | DOI: 10.1002/adhm.201700692

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      DNA origami nanostructures can be coated with well-defined protein–dendron conjugates. Plain DNA origami nanostructures often suffer from poor delivery properties, stability, and immunogenicity in biological systems. Coating of the origami with inert proteins (e.g., serum albumin) can, however, alleviate these issues efficiently.

  3. Full Papers

    1. Monodispersed Bioactive Glass Nanoclusters with Ultralarge Pores and Intrinsic Exceptionally High miRNA Loading for Efficiently Enhancing Bone Regeneration

      Yumeng Xue, Yi Guo, Meng Yu, Min Wang, Peter X. Ma and Bo Lei

      Version of Record online: 24 JUL 2017 | DOI: 10.1002/adhm.201700630

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      Monodispersed bioactive glass nanoclusters (BGNCs) with ultra-large mesopores (10–30 nm) are developed for miRNA delivery to enhance bone regeneration. BGNCs demonstrated an ultrahigh miRNA loading and transfection efficiency, overpassing commercial lipofectamine. BGNCs-mediated miRNA delivery significantly improved osteogenic differentiation of bone marrow stromal stem cells in vitro and enhanced bone formation in vivo.

    2. Newly Designed Silica-Containing Redox Nanoparticles for Oral Delivery of Novel TOP2 Catalytic Inhibitor for Treating Colon Cancer

      Long Binh Vong, Shinya Kimura and Yukio Nagasaki

      Version of Record online: 24 JUL 2017 | DOI: 10.1002/adhm.201700428

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      Novel silica-containing redox nanoparticle (siRNP) is developed to enhance the stability and drug loading capacity with reactive oxygen species (ROS) scavenging activity. Oral administration of hydrophobic drug-loaded siRNP significantly improves drug bioavailability to inhibit the tumor growth in a mouse colon cancer model. By accumulating in gastrointestinal tract, ROS scavenging capacity of siRNP suppresses the systemic side effect of anticancer drug. siRNP is a promising candidate as novel nanotherapeutic and nanocarrier for a wide range of water-insoluble chemotherapeutic agents.

    3. Controlled Exposure of Bioactive Growth Factor in 3D Amyloid Hydrogel for Stem Cells Differentiation

      Subhadeep Das, Rakesh Kumar, Narendra Nath Jha and Samir K. Maji

      Version of Record online: 24 JUL 2017 | DOI: 10.1002/adhm.201700368

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      Amyloid hydrogel for sustained growth factors delivery in tissue engineering applications. Amyloid based hydrogels can mimic the extracellular matrix and serve as matrices for tissue engineering applications both in vitro and in vivo. A pH responsive, self-assembled amyloid hydrogel system is used to encapsulate various growth factors for driving stem cell differentiation toward neuronal lineage.

  4. Communications

    1. Mechanically Tunable Bioink for 3D Bioprinting of Human Cells

      Aurelien Forget, Andreas Blaeser, Florian Miessmer, Marius Köpf, Daniela F. Duarte Campos, Nicolas H. Voelcker, Anton Blencowe, Horst Fischer and V. Prasad Shastri

      Version of Record online: 21 JUL 2017 | DOI: 10.1002/adhm.201700255

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      Carboxylated agarose hydrogels with mechanical property independent of the bioink solution viscosity allow the high-viability 3D bioprinting of human mesenchymal stem cells. Furthermore, addition of collagen to the carboxylated agarose induces the proliferation of the human mesenchymal stem cells used in this study.

  5. Full Papers

    1. Targeted Nanotherapeutics Encapsulating Liver X Receptor Agonist GW3965 Enhance Antiatherogenic Effects without Adverse Effects on Hepatic Lipid Metabolism in Ldlr−/− Mice

      Mikyung Yu, Jaume Amengual, Arjun Menon, Nazila Kamaly, Felix Zhou, Xiaoding Xu, Phei Er Saw, Seung-Joo Lee, Kevin Si, Carleena Angelica Ortega, Won Il Choi, In-Hyun Lee, Yazan Bdour, Jinjun Shi, Morteza Mahmoudi, Sangyong Jon, Edward A. Fisher and Omid C. Farokhzad

      Version of Record online: 21 JUL 2017 | DOI: 10.1002/adhm.201700313

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      A new form of liver X receptor-based therapeutics based on the nanoparticles (NPs) decorated with collagen IV targeting ligands is generated. The NPs with optimal polyethylene glycol density can successfully reach atherosclerotic lesions and enhance therapeutic efficacy of GW3965 while maintaining hepatic lipid metabolism. This targeted NP system suggests a new modality for combating inflammation in advanced atherosclerosis.

    2. Aspherical, Nanostructured Microparticles for Targeted Gene Delivery to Alveolar Macrophages

      Michael Möhwald, Shashank Reddy Pinnapireddy, Bodo Wonnenberg, Marcel Pourasghar, Marijas Jurisic, Andrea Jung, Claudia Fink-Straube, Thomas Tschernig, Udo Bakowsky and Marc Schneider

      Version of Record online: 20 JUL 2017 | DOI: 10.1002/adhm.201700478

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      A novel aspherical, nanostructured microparticle for pulmonary gene delivery is fabricated utilizing a template-assisted engineering technique. Here, nanoparticles build up rod-like shaped structures in the micrometer size range, stabilized with plasmid-DNA and polyethylenimine. The carrier provides the introduction of genes into alveolar macrophages both in vitro and in vivo, qualifying the system for the genetic engineering of immunocompetent phagocytes.

    3. Retardation of Antigen Release from DNA Hydrogel Using Cholesterol-Modified DNA for Increased Antigen-Specific Immune Response

      Yuka Umeki, Masaaki Saito, Yuki Takahashi, Yoshinobu Takakura and Makiya Nishikawa

      Version of Record online: 20 JUL 2017 | DOI: 10.1002/adhm.201700355

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      A hydrophobic interaction-based sustained release system of ovalbumin (OVA), a model antigen, from immunostimulatory cytosine-phosphate-guanine (CpG) DNA hydrogel is developed by the use of cholesterol-modified DNA and urea-denatured OVA, and this system efficiently inhibits tumor growth. This study further supports the importance of sustained release of both antigen and CpG DNA to induce antigen-specific immune responses.

    4. Multifunctional Nanotube–Mucoadhesive Poly(methyl vinyl ether-co-maleic acid)@Hydroxypropyl Methylcellulose Acetate Succinate Composite for Site-Specific Oral Drug Delivery

      Nattha Kerdsakundee, Wei Li, João Pedro Martins, Zehua Liu, Feng Zhang, Marianna Kemell, Alexandra Correia, Yaping Ding, Mikko Airavaara, Jouni Hirvonen, Ruedeekorn Wiwattanapatapee and Hélder A. Santos

      Version of Record online: 17 JUL 2017 | DOI: 10.1002/adhm.201700629

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      Multifunctional nano-in-micro particles composed of mucoadhesive polymer modified halloysite nanotubes and pH-responsive polymer are developed by microfluidics for oral drug delivery applications. The microparticles can release the drug site specifically in response to the pH condition of small intestine, strongly interact with small intestine, and significantly increase the permeability of a poorly water-soluble drug.

    5. Surface-Modified Mesh Filter for Direct Nucleic Acid Extraction and its Application to Gene Expression Analysis

      Jae Bem You, Yong Tae Kim, Kyoung G. Lee, Yunho Choi, Seongkyun Choi, Chi Hyun Kim, Kyung Hoon Kim, Sung Jin Chang, Tae Jae Lee, Seok Jae Lee and Sung Gap Im

      Version of Record online: 17 JUL 2017 | DOI: 10.1002/adhm.201700642

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      A surface-modified mesh filter (SMF) is devised via initiated chemical vapor deposition (iCVD) for convenient extraction, amplification, and detection of nucleic acids (NAs). The iCVD polymer coated on the filter interacts with NAs by charge interaction and facilitates NA extraction from cell lysate without the use of extra instrumentation. Foodborne pathogen can also be detected from real food samples using the SMF.

  6. Communications

    1. Stretchable Dry Electrodes with Concentric Ring Geometry for Enhancing Spatial Resolution in Electrophysiology

      Kaiping Wang, Udit Parekh, Tejaswy Pailla, Harinath Garudadri, Vikash Gilja and Tse Nga Ng

      Version of Record online: 17 JUL 2017 | DOI: 10.1002/adhm.201700552

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      Multichannel concentric-ring electrodes are stencil printed on stretchable elastomers modified to improve adhesion to skin and minimize motion artifacts for electrophysiological recordings of electroencephalography, electromyography, and electrocardiography. These dry electrodes show lower noise than that of commercial gel electrodes. This work shows a new fabrication approach to integrate and create designs that enhance spatial resolution for high-quality electrophysiology monitoring devices.

  7. Full Papers

    1. Direct Laser Interference Patterning of CoCr Alloy Surfaces to Control Endothelial Cell and Platelet Response for Cardiovascular Applications

      Romain Schieber, Federico Lasserre, Michael Hans, Marc Fernández-Yagüe, Maribel Díaz-Ricart, Ginés Escolar, Maria-Pau Ginebra, Frank Mücklich and Marta Pegueroles

      Version of Record online: 17 JUL 2017 | DOI: 10.1002/adhm.201700327

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      This work offers a new use of direct laser interference patterning (DLIP) technique, on cobalt-chromium (CoCr) alloys, to obtain linear patterned and chemically modified surfaces. The obtained topography induces endothelial cell alignment and migration, and, chemical changes reduce platelet adhesion. Consequently, DLIP can be a one-step technique to obtain surfaces with the capacity to enhance endothelialization and reduce thrombogenicity.

    2. pH-Responsive Nanoscale Coordination Polymer for Efficient Drug Delivery and Real-Time Release Monitoring

      Kai Han, Wei-Yun Zhang, Jin Zhang, Zhao-Yu Ma and He-You Han

      Version of Record online: 17 JUL 2017 | DOI: 10.1002/adhm.201700470

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      A nanoscale coordination polymer is developed to deliver drug to tumor tissue and realize real-time monitoring of drug release. Extremely high drug loading efficiency is achieved, and pH-responsive drug release in lysosome is monitored by the recovered fluorescence of drug itself. Importantly, this polyphenol-rich coordination polymer significantly inhibits tumor growth with negligible heart toxicity.

    3. Egg Albumen as a Fast and Strong Medical Adhesive Glue

      Kaige Xu, Yuqing Liu, Shousan Bu, Tianyi Wu, Qiang Chang, Gurankit Singh, Xiaojian Cao, Chuang Deng, Bingyun Li, Gaoxing Luo and Malcolm Xing

      Version of Record online: 17 JUL 2017 | DOI: 10.1002/adhm.201700132

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      Egg albumen adhesive (EAA) is formed by simply adding raw egg albumen powder to water. EAA exhibits outstanding adhesion strength on pigskin tissues, polydimethylsiloxane, and glass substrates especially. EAA on nanofibrous mesh shows reliable biocompatibility and biodegradability, and great wound closure performance. EAA also has exceptional underwater adhesive strength when combined with Vaseline.

  8. Communications

    1. Impermeable Robust Hydrogels via Hybrid Lamination

      German A. Parada, Hyunwoo Yuk, Xinyue Liu, Alex J. Hsieh and Xuanhe Zhao

      Version of Record online: 17 JUL 2017 | DOI: 10.1002/adhm.201700520

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      A general and versatile strategy to develop robust, stretchable and impermeable hydrogel laminates is presented to overcome common limitations of hydrogel materials such as weak mechanical properties and permeability. The laminates have tunable mechanical properties and enable spatial control of the sensing and release properties, as demonstrated by drug release and pH sensing to different sides of the laminate.

    2. Centrifugal Lithography: Self-Shaping of Polymer Microstructures Encapsulating Biopharmaceutics by Centrifuging Polymer Drops

      Huisuk Yang, Suyong Kim, Geonwoo Kang, Shayan F. Lahiji, Mingyu Jang, Young Mi Kim, Jae-Myung Kim, Sang-Nae Cho and Hyungil Jung

      Version of Record online: 13 JUL 2017 | DOI: 10.1002/adhm.201700326

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      Centrifugal lithography (CL)enables fabrication of polymer microstructures via self-shaping during a centrifugation under controlled environment for biopharmaceutics. Dissolving microneedle (DMN) array composed of hyaluronic acid and tuberculin purified protein derivatives (PPD) is fabricated by CL under refrigerated conditions (4 °C) to preserve PPD. Diagnosis of tuberculosis with the DMNs indicates minimal damage, as opposed to the traditional hypodermic needles.

  9. Full Papers

    1. Self-Normalized Detection of ANXA3 from Untreated Urine of Prostate Cancer Patients without Digital Rectal Examination

      Minhong Jeun, Sungwook Park, Yongdeok Kim, Jaewon Choi, Sang Hoon Song, In Gab Jeong, Choung-Soo Kim and Kwan Hyi Lee

      Version of Record online: 13 JUL 2017 | DOI: 10.1002/adhm.201700449

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      The IRUS (ion-responsive urine sensor) proposed is capable of quantitative analyzing minuscule amounts of prostate cancer biomarkers from untreated patient's urine samples by self-normalizing method. The IRUS has a low limit of detection (≈1 fg mL−1) as well as high reliability and sensitivity. The quantitative analysis of the biomarkers is useful to predict the prostate tumor volume of the patients.

    2. Timed Delivery of Therapy Enhances Functional Muscle Regeneration

      Christine A. Cezar, Praveen Arany, Sarah A. Vermillion, Bo Ri Seo, Herman H. Vandenburgh and David J. Mooney

      Version of Record online: 13 JUL 2017 | DOI: 10.1002/adhm.201700202

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      Externally actuated ferrogels are used to demonstrate the importance of timing of biologic therapies with respect to injury-induced inflammation. Delaying treatment until the peak of inflammation leads to both early and long-term regenerative benefits surpassing those seen with treatment initiated at the time of injury. This strategy can likely be applied broadly to both new and existing cell transplantation therapies.

  10. Comments

    1. Response to “Correspondence Concerning Hemocompatibility of Superhemophobic Titania Surfaces”

      S. Movafaghi, V. Leszczak, W. Wang, J. A. Sorkin, L. P. Dasi, K. C. Popat and A. K. Kota

      Version of Record online: 13 JUL 2017 | DOI: 10.1002/adhm.201700647

  11. Communications

    1. Phospholipid Capped Mesoporous Nanoparticles for Targeted High Intensity Focused Ultrasound Ablation

      Adem Yildirim, Rajarshi Chattaraj, Nicholas T. Blum, Dennis Shi, Kaushlendra Kumar and Andrew P. Goodwin

      Version of Record online: 12 JUL 2017 | DOI: 10.1002/adhm.201700514

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      High intensity focused ultrasound (HIFU) is promising for tissue ablation but suffers from off-target side effects. This work reports 100 nm mesoporous, hydrophobically modified silica nanoparticles coated with phospholipid monolayers, polyethylene glycol, and folate. These particles are uptaken into breast cancer cells without change in viability, but administration of HIFU with uptaken particles results in cell death.

    2. Promoting Cell Migration in Tissue Engineering Scaffolds with Graded Channels

      Degang Yang, Zhitong Zhao, Fan Bai, Shutao Wang, Antoni P. Tomsia and Hao Bai

      Version of Record online: 12 JUL 2017 | DOI: 10.1002/adhm.201700472

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      Cell migration within 3D scaffolds is crucial for bone regeneration at critical size defects. Here, hydroxyapatite scaffolds with different microstructures are fabricated. Cell migration is greatly promoted within the scaffolds with graded channels comparing with those having tortuous or parallel channels. The results provide new insights and guidance for designing novel scaffolds to regulate cell migration behavior for bone regeneration.

    3. You have full text access to this OnlineOpen article
      Enzyme Prodrug Therapy Engineered into Electrospun Fibers with Embedded Liposomes for Controlled, Localized Synthesis of Therapeutics

      Rona Chandrawati, Morten T. J. Olesen, Thatiane C. C. Marini, Gurpal Bisra, Anne Géraldine Guex, Marcelo G. de Oliveira, Alexander N. Zelikin and Molly M. Stevens

      Version of Record online: 12 JUL 2017 | DOI: 10.1002/adhm.201700385

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      β-glucuronidase is an enzyme with historically validated performance in enzyme prodrug therapy, however β-glucuronidase retains its activity in biomaterials for an insufficiently long period of time, typically not exceeding 7 d. Here, encapsulation of β-glucuronidase in liposomal subcompartments within electrospun fibers affords a highly stable preparation of biocatalytically active materials with activity of the enzyme sustained over at least seven weeks.

  12. Full Papers

    1. Melt Electrospinning Writing of Poly-Hydroxymethylglycolide-co-ε-Caprolactone-Based Scaffolds for Cardiac Tissue Engineering

      Miguel Castilho, Dries Feyen, María Flandes-Iparraguirre, Gernot Hochleitner, Jürgen Groll, Pieter A. F. Doevendans, Tina Vermonden, Keita Ito, Joost P. G. Sluijter and Jos Malda

      Version of Record online: 12 JUL 2017 | DOI: 10.1002/adhm.201700311

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      Fabrication of highly ordered microfiber scaffolds for cardiac tissue engineering is achieved by melt electrospinning writing of a hydroxyl-functionalized polyester. These scaffolds can support and guide the growth of cardiac progenitor cells while recapitulating the mechanical environment of the native cardiac tissue. This approach provides a framework for the development of therapeutically viable in vitro engineered cardiac tissues.

    2. tBHQ Suppresses Osteoclastic Resorption in Xenogeneic-Treated Dentin Matrix-Based Scaffolds

      Jingjing Sun, Jie Li, Hui Li, Hefeng Yang, Jinlong Chen, Bo Yang, Fangjun Huo, Weihua Guo and Weidong Tian

      Version of Record online: 11 JUL 2017 | DOI: 10.1002/adhm.201700127

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      Xenogeneic-treated dentin matrix (xTDM)-based scaffolds present severe osteolysis and resorption lacunae causing regenerated tooth root failure. Antioxidant, tert-butylhydroquinone (tBHQ), inhibits xTDM seeded with allogeneic dental follicle cells (xTDM/aDFCs)-induced osteoclastogenesis and reduces osteolysis and osteoclastic resorption of xTDM/aDFCs scaffolds. The regenerated tooth root constructed of xTDM and aDFCs keep intact and regular in jaws of rhesus macaques under tBHQ treatment.

    3. Evaluation of Electrical Impedance Spectroscopy-on-a-Needle as a Novel Tool to Determine Optimal Surgical Margin in Partial Nephrectomy

      Hyeon Woo Kim, Joho Yun, Jeong Zoo Lee, Dong Gil Shin and Jong-Hyun Lee

      Version of Record online: 11 JUL 2017 | DOI: 10.1002/adhm.201700356

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      Electrical impedance spectroscopy (EIS) on a hypodermic needle to determine optimal surgical margin during partial nephrectomy (PN). The electrical impedance differences between renal parenchymal tissues and renal cell carcinoma tumors are investigated with regard to the distance from the tumors.

  13. Comments

    1. Comment on: “Hemocompatibility of Superhemophobic Titania Surfaces”

      Steffen Braune, Robert A. Latour, Andreas Lendlein and Friedrich Jung

      Version of Record online: 10 JUL 2017 | DOI: 10.1002/adhm.201700294

  14. Full Papers

    1. Electrostimulated Release of Neutral Drugs from Polythiophene Nanoparticles: Smart Regulation of Drug–Polymer Interactions

      Anna Puiggalí-Jou, Paolo Micheletti, Francesc Estrany, Luis J. del Valle and Carlos Alemán

      Version of Record online: 3 JUL 2017 | DOI: 10.1002/adhm.201700453

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      An electric-field-responsive polymeric nanoparticles system for programmed drug delivery is presented. More specifically, curcumine loaded into stabilized poly(3,4-ethylenedioxythiophene) electroactive nanoparticles is released by applying a controlled external voltage. Curcumine···polymer interactions are crucial to regulate the release. This nontoxic biocompatible system is of potential use for advanced biomedical applications.

    2. Ultrasound-Triggered Destruction of Folate-Functionalized Mesoporous Silica Nanoparticle-Loaded Microbubble for Targeted Tumor Therapy

      Yongjiu Lv, Yang Cao, Pan Li, Jianxin Liu, Huali Chen, Wenjing Hu and Liangke Zhang

      Version of Record online: 3 JUL 2017 | DOI: 10.1002/adhm.201700354

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      A novel drug delivery vehicle based on folate-modified mesoporous silica nanoparticles and microbubbles is designed and fabricated. The resulting multifunctional vehicle, which combines the merits of high drug loading capacity, multitargeting, and ultrasound-guided drug release, can enhance the efficacy of anticancer drugs, reduce undesirable side effects, and provide a new strategy for tumor targeting.

  15. Communications

    1. Superoxide Dismutase-Loaded Porous Polymersomes as Highly Efficient Antioxidants for Treating Neuropathic Pain

      Sonia Kartha, Lesan Yan, Christine L. Weisshaar, Meagan E. Ita, Vladimir V. Shuvaev, Vladimir R. Muzykantov, Andrew Tsourkas, Beth A. Winkelstein and Zhiliang Cheng

      Version of Record online: 3 JUL 2017 | DOI: 10.1002/adhm.201700500

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      Highly efficient antioxidants based on superoxide dismutase (SOD)-loaded porous polymersomes are developed for treating neuropathic pain. The SOD-loaded porous polymersomes are highly permeable to superoxide radical, while retaining the antioxidant enzyme within their aqueous interiors. Administration of the antioxidant porous polymersomes following a painful nerve root compression is substantially more effective in preventing the onset of pain in rats than comparable or higher doses of free SOD alone.

  16. Full Papers

    1. The Spontaneous Adhesion of BMMC onto Self-Assembled Peptide Nanoscaffold without Activation Inhibits Its IgE-Mediated Degranulation

      Lei Lu, Narcy Arizmendi, Marianna Kulka and Larry D. Unsworth

      Version of Record online: 30 JUN 2017 | DOI: 10.1002/adhm.201700334

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      Herein, for the first time, the effect of self-assembling (RADA)4 nanoscaffold on bone-marrow-derived murine mast cell (BMMC) activities is reported. BMMCs can spontaneously adhere to the synthetic matrix without stimulation. The nanofiber network selectively inhibits IgE-mediated degranulation of adhered BMMC, but not A23187-mediated degranulation. Moreover, tumor necrosis factor α released from adherent BMMCs can be significantly absorbed by the matrix.

  17. Communications

    1. Multifunctional Polymeric Micelles for Combining Chelation and Detection of Iron in Living Cells

      Zhi Liu, Max Purro, Jing Qiao and May P. Xiong

      Version of Record online: 29 JUN 2017 | DOI: 10.1002/adhm.201700162

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      Multifunctional Pluronics F127 micelles are constructed for iron chelation and fluorescence detection by introducing tetraphenylethene and the chelating drug deferoxamine into self-assembling polymeric micelles. Deferoxamine can simultaneously be used to chelate iron(III) and quench the fluorescence emission of tetraphenylethene. This fluorescence “turn-off” process can be used to monitor the iron chelation process in an iron overload cell model.

  18. Full Papers

    1. Efficient Skin Temperature Sensor and Stable Gel-Less Sticky ECG Sensor for a Wearable Flexible Healthcare Patch

      Yuki Yamamoto, Daisuke Yamamoto, Makoto Takada, Hiroyoshi Naito, Takayuki Arie, Seiji Akita and Kuniharu Takei

      Version of Record online: 29 JUN 2017 | DOI: 10.1002/adhm.201700495

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      The effect of film thickness on the precision of monitoring skin temperature as well as a gel-less sticky electrode for electrocardiogram monitoring is studied in this report. Based on the optimized sensor sheet structure, real-time healthcare recording is successfully demonstrated.

  19. Communications

    1. 3D Near-Field Electrospinning of Biomaterial Microfibers with Potential for Blended Microfiber-Cell-Loaded Gel Composite Structures

      Pouria Fattahi, Jordan T. Dover and Justin L. Brown

      Version of Record online: 29 JUN 2017 | DOI: 10.1002/adhm.201700456

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      3D Near-Field Electrospinning (3DNFES) is a new method for printing polymeric fibers in highly organized, controlled, and reproducible manner. 3DNFES offers several significant advantages including: (1) producing precise patterns of fibers on relatively large-scale area, (2) printing in all three directions, (3) offering an inexpensive method, and (4) readily combines with other prepatterned nanostructures or microstructures such as gels.

  20. Full Papers

    1. Liposomes with Silk Fibroin Hydrogel Core to Stabilize bFGF and Promote the Wound Healing of Mice with Deep Second-Degree Scald

      He-Lin Xu, Pian-Pian Chen, De-Li ZhuGe, Qun-Yan Zhu, Bing-Hui Jin, Bi-Xin Shen, Jian Xiao and Ying-Zheng Zhao

      Version of Record online: 29 JUN 2017 | DOI: 10.1002/adhm.201700344

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      Maintaining the stability of basic fibroblast growth factor (bFGF) in wound fluids is important to accelerate wound healing. In this study, a novel liposome (LIP) with silk fibroin (SF) hydrogel core has been proposed as an innovative carrier of bFGF for deep second-degree scald. Due to the protective effect and enhanced penetration ability, SF-bFGF-LIP exhibits a better wound healing effect than free bFGF or the common bFGF-liposome.

    2. Cotransporting Ion is a Trigger for Cellular Endocytosis of Transporter-Targeting Nanoparticles: A Case Study of High-Efficiency SLC22A5 (OCTN2)-Mediated Carnitine-Conjugated Nanoparticles for Oral Delivery of Therapeutic Drugs

      Longfa Kou, Qing Yao, Mengchi Sun, Chunnuan Wu, Jia Wang, Qiuhua Luo, Gang Wang, Yuqian Du, Qiang Fu, Jian Wang, Zhonggui He, Vadivel Ganapathy and Jin Sun

      Version of Record online: 29 JUN 2017 | DOI: 10.1002/adhm.201700165

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      Cotransporting ion, Na+, is found as a trigger for the proceeding of l-carnitine-conjugated poly(lactic-co-glycolic acid) (PLGA) nanoparticles (LC-PLGA NPs) targeting to Na+-coupled organic cation/carnitine transporter 2 (OCTN2). In this case, LC-PLGA NPs and Na+ bind to specific binding sites of OCTN2, and then initiate the conformation change from outward-facing to occluded state to form an energetically stable intermediate complex (OCTN2-Na+-LC-PLGA NPs). The complex induces membrane invagination and the following endocytosis.

    3. A Core–Shell-Satellite Structured Fe3O4@g-C3N4–UCNPs–PEG for T1/T2-Weighted Dual-Modal MRI-Guided Photodynamic Therapy

      Lili Feng, Dan Yang, Fei He, Shili Gai, Chunxia Li, Yunlu Dai and Piaoping Yang

      Version of Record online: 23 JUN 2017 | DOI: 10.1002/adhm.201700502

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      A multifunctional nanoplatform demonstrates NIR-irradiated, magnetic targeted, and T1/T2-weighted dual-modal magnetic resonance imaging guided photodynamic anticancer therapy. The platform is constructed by coating mesoporous g-C3N4 on Fe3O4 nanoparticles, following by attaching ultrasmall upconversion nanoparticles (UCNPs) and PEG molecules (denoted as Fe3O4@g-C3N4–UCNPs–PEG).

    4. Cell-Engineered Nanovesicle as a Surrogate Inducer of Contact-Dependent Stimuli

      Junho Kim, Chugmin Han, Wonju Jo, Sehong Kang, Siwoo Cho, Dayeong Jeong, Yong Song Gho and Jaesung Park

      Version of Record online: 23 JUN 2017 | DOI: 10.1002/adhm.201700381

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      Cell-engineered nanovesicles (CNVs) fabricated from feeder cells successfully regulate the fates of embryonic stem cells through contact-dependent stimulus. Unlike feeder layer methods, scalable, diffusible, and storable characteristics of CNVs can constitute a novel tool for embryonic stem cell research. The CNV method might be used in various other applications that require heterotipic cell–cell interactions.

  21. Progress Reports

    1. Interactions of Neurons with Physical Environments

      Michal Marcus, Koby Baranes, Matthew Park, Insung S. Choi, Kyungtae Kang and Orit Shefi

      Version of Record online: 22 JUN 2017 | DOI: 10.1002/adhm.201700267

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      Neurons rely on physical signals throughout development and regeneration. Recent advances in fabrication and materials led to the development of 2D and 3D engineered platforms that can mimic the native extracellular environment. This Progress Report exploits studies of platforms generated with a range of physical topographies, from micro- down to nano- scale, that interact effectively with neurons, affecting differentiation, outgrowth and activity. Matching these specific needs may advance therapies and brain-machine interface applications.

  22. Full Papers

    1. Multicompartment Drug Release System for Dynamic Modulation of Tissue Responses

      Aaron H. Morris, Rajwant S. Mahal, Jillian Udell, Michelle Wu and Themis R. Kyriakides

      Version of Record online: 21 JUN 2017 | DOI: 10.1002/adhm.201700370

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      A multicompartment drug release system is developed for dynamic modulation of tissue responses. The system is composed of electrosprayed spheres embedded within an electrospun mat of core–shell fibers. Different compartments are formed that are capable of releasing drugs over distinct timescales. When anti-inflammatory and antifibrotic drugs are incorporated, these systems are able to reduce the foreign body response to implants.

    2. Directional Matrix Nanotopography with Varied Sizes for Engineering Wound Healing

      Jangho Kim, Won-Gyu Bae, Yeon Ju Kim, Hoon Seonwoo, Han-Wool Choung, Kyoung-Je Jang, Sunho Park, Bog Hee Kim, Hong-Nam Kim, Kyoung Soon Choi, Myung-Sun Kim, Pill-Hoon Choung, Yun-Hoon Choung and Jong Hoon Chung

      Version of Record online: 21 JUN 2017 | DOI: 10.1002/adhm.201700297

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      Nanotopographic features play a crucial role in the regulation of physiologically relevant cell and tissue functions. Here, the feature-size-dependent cell–nanoarchitecture interactions are systemically analyzed using an array of directional matrix nanotopography. It is shown that the properties of repaired tissue matrices in the process of dermis wound healing may be controlled via nanotopographical density-mediated cellular behaviors.

    3. Nonmediated, Label-Free Based Detection of Cardiovascular Biomarker in a Biological Sample

      JuKyung Lee, SuRyon Shin, Anna Desalvo, Geonhui Lee, Jeong Yoon Lee, Alessandro Polini, Sukyoung Chae, Hobin Jeong, Jonghan Kim, Haksoo Choi and HeaYeon Lee

      Version of Record online: 21 JUN 2017 | DOI: 10.1002/adhm.201700231

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      “Direct monitoring with nonmediator” is demonstrated based on impedance spectroscopy under the culture medium in order to overcome the limitation of mediator. The applicability of electrochemical monitoring is shown by detecting alpha-1-anti trypsin, which is known as biomarkers for cardiac damage and is widely chosen in organoid cardiac cell-based chip.

  23. Reviews

    1. You have free access to this content
      Bioinspired Collagen Scaffolds in Cranial Bone Regeneration: From Bedside to Bench

      Justine C. Lee and Elizabeth J. Volpicelli

      Version of Record online: 6 JUN 2017 | DOI: 10.1002/adhm.201700232

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      In this review all of the current extracellular matrix-inspired, collagen-based materials reported in the literature with in vivo success in cranial defect healing in relationship to the clinical indications and challenges of cranial defect reconstruction are summarized. Future multi-disciplinary strategies in translating innovative materials to clinical medicine is discussed.

  24. Progress Reports

    1. You have free access to this content
      Bridging the Knowledge of Different Worlds to Understand the Big Picture of Cancer Nanomedicines

      Vimalkumar Balasubramanian, Zehua Liu, Jouni Hirvonen and Hélder A. Santos

      Version of Record online: 1 JUN 2017 | DOI: 10.1002/adhm.201700432

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      Nanomedicine is emerging as effective therapeutic strategy for cancer therapy. As cancer nanomedicines are at the interface of diverse fields along with complexities lying in nanomedicines and cancer, demanding for an multidisciplinary efforts to advance the understanding and development of cancer-specific nanomedicines are needed to meet the current challenges in translating them into the clinic.

  25. Full Papers

    1. Graphene Oxide/Ag Nanoparticles Cooperated with Simvastatin as a High Sensitive X-Ray Computed Tomography Imaging Agent for Diagnosis of Renal Dysfunctions

      Zhan Li, Longlong Tian, Jianli Liu, Wei Qi, Qiang Wu, Haijing Wang, Mohammad Chand Ali, Wangsuo Wu and Hongdeng Qiu

      Version of Record online: 31 MAY 2017 | DOI: 10.1002/adhm.201700413

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      Graphene oxide and Ag nanoparticle nanocoposites are prepared as enhanced contrast agent of computed tomography (CT) imaging in the presence of simvastatin, which exhibit excellent performance for in vivo CT imaging of the lung, liver, and renal perfusion, and intuitively diagnose the disease of the right renal in renal dysfunction mice.

  26. Reviews

    1. ‘Printability' of Candidate Biomaterials for Extrusion Based 3D Printing: State-of-the-Art

      Stuart Kyle, Zita M. Jessop, Ayesha Al-Sabah and Iain S. Whitaker

      Version of Record online: 30 MAY 2017 | DOI: 10.1002/adhm.201700264

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      3D bioprinting has the potential to replicate complex tissue architecture and biomanufacture physiologically relevant multicellular constructs on demand. Advanced functional biomaterials, a new generation of bioinks with suitable biocompatibility and high shape/print fidelity, when combined with the appropriate cell source have the potential to match or exceed the physical, chemical and biological properties of human tissue. Successful clinical translation would revolutionize patient care.

  27. Full Papers

    1. Understanding the Effect of Surface Chemistry of Mesoporous Silica Nanorods on Their Vaccine Adjuvant Potency

      Yannan Yang, Manasi Jambhrunkar, Prasanna Lakshmi Abbaraju, Meihua Yu, Min Zhang and Chengzhong Yu

      Version of Record online: 29 MAY 2017 | DOI: 10.1002/adhm.201700466

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      The surface chemistry of mesoporous silica nanorods (MSNR) shows significant impact on their adjuvant potency. Compared to pristine MSNR with [BOND]OH surface group, highly hydrophobic [BOND]C18 functionalization displays significantly enhanced both humoral and cellular mediated immune response, while [BOND]NH2 modification only moderately improves humoral immunity. These findings may provide useful guidance for the rational design of effective silica based vaccines.

  28. Communications

    1. Wet-AMD on a Chip: Modeling Outer Blood-Retinal Barrier In Vitro

      Minhwan Chung, Somin Lee, Byung Joo Lee, Kyungmin Son, Noo Li Jeon and Jeong Hun Kim

      Version of Record online: 29 MAY 2017 | DOI: 10.1002/adhm.201700028

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      On-chip model of wet type age-related macular degeneration (AMD) that causes severe vision loss in the elderly is described. A process that destructs integrity of retinal pigment epithelium by angiogenesis of choroid vessel, a main pathological process of wet-AMD called choroidal neovascularization (CNV), is reconstituted on a microfluidic platform. Inhibitory effect of a therapeutic antiangiogenic compound on CNV is demonstrated.

    2. Biomimetic Model of Tumor Microenvironment on Microfluidic Platform

      Minhwan Chung, Jungho Ahn, Kyungmin Son, Sudong Kim and Noo Li Jeon

      Version of Record online: 24 MAY 2017 | DOI: 10.1002/adhm.201700196

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      A biomimetic tumor microenvironment model that mimics simultaneous angiogenesis and lymphangiogenesis toward tumor mass is created in microfluidic platform. Tumor–stromal mixture induces natural morphogenesis of endothelial cells to migrate through 3D fibrin matrix and interacts directly with the tumor cells. This model can potentially be used not only in drug evaluation but also in studying complex tumor microenvironment systematically.

  29. Full Papers

    1. You have free access to this content
      3D Bioprinting Human Induced Pluripotent Stem Cell Constructs for In Situ Cell Proliferation and Successive Multilineage Differentiation

      Qi Gu, Eva Tomaskovic-Crook, Gordon G. Wallace and Jeremy M. Crook

      Version of Record online: 24 MAY 2017 | DOI: 10.1002/adhm.201700175

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      Human tissues are generated by 3D bioprinting human induced pluripotent stem cells that proliferate and differentiate to form renewable 3D tissues. 3D tissues comprise cells of the three germ lineages—endoderm, ectoderm, and mesoderm, demonstrating the capacity to form all cells and tissues of the body, or more homogeneous neural tissues containing functional (including migrating) neurons and supporting neuroglia.

  30. Communications

    1. Dual Cross-Linked Biofunctional and Self-Healing Networks to Generate User-Defined Modular Gradient Hydrogel Constructs

      Zhao Wei, Daniel M. Lewis, Yu Xu and Sharon Gerecht

      Version of Record online: 23 MAY 2017 | DOI: 10.1002/adhm.201700523

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      A user-defined modular gradient hydrogel system is developed by using dual cross-linked biofunctional and self-healing networks. The modular gradient hydrogel construct can be generated with various gradient distributions and flexible shapes as defined by users. The encapsulated cells are responsive to the gradient cues in the hydrogel construct, which holds potential to study cellular responses to their tissue microenvironment.

  31. Full Papers

    1. Bioprinted Osteogenic and Vasculogenic Patterns for Engineering 3D Bone Tissue

      Batzaya Byambaa, Nasim Annabi, Kan Yue, Grissel Trujillo-de Santiago, Mario Moisés Alvarez, Weitao Jia, Mehdi Kazemzadeh-Narbat, Su Ryon Shin, Ali Tamayol and Ali Khademhosseini

      Version of Record online: 19 MAY 2017 | DOI: 10.1002/adhm.201700015

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      The authors develop a strategy for engineering vascularized bone tissue through bioprinting using cell-laden gelatin methacryloyl (GelMA) hydrogels. The authors bioprint human umbilical vein endothelial cells laden fiber for blood vessel formation surrounded by GelMA fibers containing human mesenchymal stem cells for bone generation. The vascular vessel enables continuous perfusion and supports in vitro bone tissue formation and maturation.

    2. Taxane-Grafted Metal-Oxide Nanoparticles as a New Theranostic Tool against Cancer: The Promising Example of Docetaxel-Functionalized Titanate Nanotubes on Prostate Tumors

      Alexis Loiseau, Julien Boudon, Céline Mirjolet, Gilles Créhange and Nadine Millot

      Version of Record online: 18 MAY 2017 | DOI: 10.1002/adhm.201700245

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      A new docetaxel-nanocarrier based on titanate nanotubes (TiONts) is synthesized step-by-step. Attention is paid to the elaboration of functionalized-TiONts nanohybrids in order to control the surface properties by chemical functionalization. Their efficacy is evaluated using in vitro and in vivo prostate cancer models. TiONts which combine a chemotherapeutic agent and a macrocyclic chelator appear to be an effective theranostic platform.

    3. Peptide-Functionalized Fluorescent Particles for In Situ Detection of Nitric Oxide via Peroxynitrite-Mediated Nitration

      Jason Y. H. Chang, Lesley W. Chow, W. Michael Dismuke, C. Ross Ethier, Molly M. Stevens, W. Daniel Stamer and Darryl R. Overby

      Version of Record online: 17 MAY 2017 | DOI: 10.1002/adhm.201700383

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      Peptide-conjugated fluorescent particles are developed as biosensors to detect nitric oxide (NO) based on 3-nitrotyrosine labelling. The biosensors successfully detect NO release from endothelial cells under shear stress with a sensitivity exceeding that of standard assays. The biosensors provide an integrated measure of NO in the vicinity of the fluorescent particle, thereby allowing spatiotemporal localization of NO production within biological systems.

  32. Communications

    1. Self-Assembled Nanoparticles from Phenolic Derivatives for Cancer Therapy

      Yunlu Dai, Junling Guo, Ting-Yi Wang, Yi Ju, Andrew J. Mitchell, Thomas Bonnard, Jiwei Cui, Joseph J. Richardson, Christoph E. Hagemeyer, Karen Alt and Frank Caruso

      Version of Record online: 16 MAY 2017 | DOI: 10.1002/adhm.201700467

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      A polyphenol-based therapeutic nanoparticle system for cancer therapy is prepared by self-assembly and emulsion templating. The nanoparticles have a long blood half-life, accumulate in tumors in vivo, and exhibit better inhibition of tumor growth than either free prodrug or cisplatin.

  33. Full Papers

    1. Microcarriers with Synthetic Hydrogel Surfaces for Stem Cell Expansion

      Andrew D. Dias, Jonathan M. Elicson and William L. Murphy

      Version of Record online: 16 MAY 2017 | DOI: 10.1002/adhm.201700072

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      A hydrogel coating platform for microcarriers based on interfacial polymerization is developed, enabling mesenchymal stem cell (MSC) culture and expansion. The coating system is robust, and MSCs maintain functionality in both serum-containing and serum-free media after expansion. The platform is amenable to customization for biomanufacturing applications.

    2. Topography-Guided Control of Local Migratory Behaviors and Protein Expression of Cancer Cells

      Jung-Youn Shin, Hong Nam Kim, Suk Ho Bhang, Jeong-Kee Yoon, Kahp-Yang Suh, Noo Li Jeon and Byung-Soo Kim

      Version of Record online: 16 MAY 2017 | DOI: 10.1002/adhm.201700155

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      Migration behaviors of cancer cells on various topographies are described. The migratory behaviors of cancer cells in colony are controlled by the topographical guidance or hindrance. Cells at front of the colony display most activated behavior for migration. The expression of the proteins involved in the migratory behaviors is localized in the periphery of the cell colony.

    3. Highly Luminescent Folate-Functionalized Au22 Nanoclusters for Bioimaging

      Kyunglim Pyo, Nguyen Hoang Ly, Sook Young Yoon, Yiming Shen, Seon Young Choi, So Yeong Lee, Sang-Woo Joo and Dongil Lee

      Version of Record online: 15 MAY 2017 | DOI: 10.1002/adhm.201700203

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      Folate-functionalized Au22 nanoclusters show the highest luminescence quantum yield of 42% among other water-soluble gold nanoclusters protected with thiolate ligands. The brightness is enhanced by 8-fold via the rigidification of the surface shell and energy transfer sensitization from the photoexcited folate. The highly luminescent gold clusters with excellent biocompatibility and active targeting ability are well-suited to targeted bioimaging.

    4. Broad Spectrum Macromolecular Antimicrobials with Biofilm Disruption Capability and In Vivo Efficacy

      Jeremy P. K. Tan, Daniel J. Coady, Haritz Sardon, Alexander Yuen, Shujun Gao, Shaun W. Lim, Zhen Chang Liang, Eddy W. Tan, Shrinivas Venkataraman, Amanda C. Engler, Mareva Fevre, Robert Ono, Yi Yan Yang and James L. Hedrick

      Version of Record online: 15 MAY 2017 | DOI: 10.1002/adhm.201601420

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      Biodegradable eight membered polycarbonates that exhibit broad spectrum antimicrobial activity are synthesized by organocatalytic ring-opening polymerization. These materials are nonhemolytic and nontoxic with the ability to lyse individual microbes or biofilm via membrane lytic mechanism. In a blood stream infection mouse model, the polymer, injected intravenously, removes bacteria from the blood more rapidly than the antibiotic Augmentin without causing toxicity.

    5. Multifunctional Liposomes for Image-Guided Intratumoral Chemo-Phototherapy

      Dyego Miranda, Kevin Carter, Dandan Luo, Shuai Shao, Jumin Geng, Changning Li, Upendra Chitgupi, Steven G. Turowski, Nasi Li, G. Ekin Atilla-Gokcumen, Joseph A. Spernyak and Jonathan F. Lovell

      Version of Record online: 15 MAY 2017 | DOI: 10.1002/adhm.201700253

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      Porphyrin–phospholipid (PoP) liposomes are developed to load three hydrophilic cargo: a fluorophore for tracking cargo release; a magnetic resonance imaging agent for monitoring tumor distribution; and a chemotherapeutic. PoP liposomes rapidly release all cargos concurrently under near infrared light. Intratumoral injections are used to demonstrate chemo-phototherapy under image guidance.

    6. A Ferroelectric Ceramic/Polymer Composite-Based Capacitive Electrode Array for In Vivo Recordings

      Changyong Chen, Miaomiao Xue, Yige Wen, Guang Yao, Yan Cui, Feiyi Liao, Zhuocheng Yan, Long Huang, Saeed Ahmed Khan, Min Gao, Taisong Pan, Hulin Zhang, Wei Jing, Daqing Guo, Sanfeng Zhang, Hailiang Yao, Xiong Zhou, Qiang Li, Yang Xia and Yuan Lin

      Version of Record online: 11 MAY 2017 | DOI: 10.1002/adhm.201700305

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      A new implantable capacitive electrode array for electrocorticography signal recording is developed with barium titanate/polyimide (BaTiO3/PI) nanocomposite. This ultrathin and electrically safe capacitive BaTiO3/PI electrode array is capable of attaching to the biological tissue conformably. In vivo neural experiments indicate its feasibility. This work shows the potentials of capacitive BaTiO3/PI electrode arrays in the field of brain/computer interfaces.

    7. Clickable Microgel Scaffolds as Platforms for 3D Cell Encapsulation

      Alexander S. Caldwell, Gavin T. Campbell, Kelly M. T. Shekiro and Kristi S. Anseth

      Version of Record online: 9 MAY 2017 | DOI: 10.1002/adhm.201700254

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      Microgel “building blocks” are designed and assembled in the presence of cells to create polymer-cell composites. These materials have highly tunable mechanical and chemical properties, allowing for a highly versatile cell culture platform.

  34. Progress Reports

    1. You have full text access to this OnlineOpen article
      Mechanotransduction and Growth Factor Signalling to Engineer Cellular Microenvironments

      Amaia Cipitria and Manuel Salmeron-Sanchez

      Version of Record online: 8 MAY 2017 | DOI: 10.1002/adhm.201700052

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      The combination of physical stimuli and growth factor is essential to engineer advanced cellular microenvironments with impact in stem cell technologies, cancer research and regenerative medicine. This progress report discusses the role of properties such as stiffness, geometry, viscoelasticity and other dynamic properties as well as their combination with growth factor presentation in controlling (stem) cell behaviour.

  35. Communications

    1. Bioinspired Pollen-Like Hierarchical Surface for Efficient Recognition of Target Cancer Cells

      Wenshuo Wang, Gao Yang, Haijun Cui, Jingxin Meng, Shutao Wang and Lei Jiang

      Version of Record online: 4 MAY 2017 | DOI: 10.1002/adhm.201700003

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      A pollen-like hierarchical surface is developed by combining a filtering-assisted assembly method and soft lithography. The as-prepared surface can enable the capture of target cancer cells with high efficiency and specificity after modification with recognition agent. The work represents a good example of constructing cell recognition biointerfaces inspired by pollen–stigma adhesion.

  36. Full Papers

    1. You have free access to this content
      Desmoplastic Reaction in 3D-Pancreatic Cancer Tissues Suppresses Molecular Permeability

      Michiya Matsusaki, Misaki Komeda, Simona Mura, Hiroyoshi Y. Tanaka, Mitsunobu R. Kano, Patrick Couvreur and Mitsuru Akashi

      Version of Record online: 27 APR 2017 | DOI: 10.1002/adhm.201700057

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      The design and characterization of in vitro pancreatic cancer–stromal 3D-tissues are reported, which enhance the current understanding of the interactions between cancer cells and fibroblasts and characterize the influence on the secretion of extracellular matrix (ECM). The 3D-pancreatic cancer tissues display a decrease in molecular permeability with increasing secretion of ECM proteins through cancer–stromal cell interactions.

  37. Communications

    1. Modulation of Heterotypic and Homotypic Cell–Cell Interactions via Zwitterionic Lipid Masks

      Matthew Park, Wongu Youn, Doyeon Kim, Eun Hyea Ko, Beom Jin Kim, Sung Min Kang, Kyungtae Kang and Insung S. Choi

      Version of Record online: 21 APR 2017 | DOI: 10.1002/adhm.201700063

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      Easily removable, cell-repellant masks are developed based on zwitterioinic lipids to spatio-selectively seed cells for the study of cell–cell interactions. Prior fabrication methods have often required restrictive conditions or technically complex procedures, but this lipid-based strategy offers a simple and highly biocompatible means of restricting cell adhesion to specified areas, allowing for studies on heterotypic cocultures and collective migration.

    2. Rod-Shaped Neural Units for Aligned 3D Neural Network Connection

      Midori Kato-Negishi, Hiroaki Onoe, Akane Ito and Shoji Takeuchi

      Version of Record online: 21 APR 2017 | DOI: 10.1002/adhm.201700143

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      Assembly of four cortical units—fabricated microfiber-shaped neural tissues with cortical cells. Each unit has an insulated region covered with a thin alginate hydrogel layer to prevent the encapsulated neural tissues from connecting to surrounding cells within the regions; the edges of the unit are connectable, with the spherical ends functioning as glue to connect with other units.

  38. Full Papers

    1. The Role of Titanium Surface Nanostructuring on Preosteoblast Morphology, Adhesion, and Migration

      Yulia Zhukova, Christian Hiepen, Petra Knaus, Marc Osterland, Steffen Prohaska, John W. C. Dunlop, Peter Fratzl and Ekaterina V. Skorb

      Version of Record online: 30 MAR 2017 | DOI: 10.1002/adhm.201601244

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      Different nanotopologies are generated on the surface of titanium implants by ultrasound treatment (left) and by anodic oxidation (right). The structural differences influence morphology and migration behavior of preosteoblastic cells growing on these surfaces. A quantitative wound healing assay in combination with live-cell imaging reveals more collective cell migration behavior on the disordered mesoporous surfaces generated by sonochemistry (left).

    2. Control of Cell Alignment and Morphology by Redesigning ECM-Mimetic Nanotopography on Multilayer Membranes

      Maria P. Sousa, Sofia G. Caridade and João F. Mano

      Version of Record online: 29 MAR 2017 | DOI: 10.1002/adhm.201601462

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      Flexible and freestanding biomimetic multilayer membranes, which topography resemble the nanofeatures of the extracellular matrix, are successfully developed using a friendly user layer-by-layer technology. The ability to crosslink with genipin as well as the presence of a patterned topography on the surface of the natural-based membranes provides a promising system to tailor cellular behavior including cell alignment and differentiation.

    3. Transdermal Protein Delivery Using Choline and Geranate (CAGE) Deep Eutectic Solvent

      Amrita Banerjee, Kelly Ibsen, Yasunori Iwao, Michael Zakrewsky and Samir Mitragotri

      Version of Record online: 24 MAR 2017 | DOI: 10.1002/adhm.201601411

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      Choline and geranate (CAGE) significantly enhances transdermal protein delivery. CAGE acts as an effective material for transdermal drug delivery. Proteins simply dispersed in CAGE retain their secondary conformation and traverse through the skin to demonstrate significantly higher in vivo efficacy compared to proteins in buffer.

  39. Reviews

    1. Materials for Microfluidic Immunoassays: A Review

      Lei Mou and Xingyu Jiang

      Version of Record online: 21 MAR 2017 | DOI: 10.1002/adhm.201601403

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      Microfluidic immunoassays for point-of-care diagnostics can detect biomarkers in a faster and easier way compared to traditional approaches. This Review reports on the materials-related aspects of the recent advances in microfluidic immunoassays including materials for chips fabrication and materials for improving the performance of immunoassays. Some clinical practice, and commercial products in the market have also been discussed.

  40. Full Papers

    1. Selectively Inducing Cancer Cell Death by Intracellular Enzyme-Instructed Self-Assembly (EISA) of Dipeptide Derivatives

      Jie Li, Junfeng Shi, Jamie E. Medina, Jie Zhou, Xuewen Du, Huaimin Wang, Cuihong Yang, Jianfeng Liu, Zhimou Yang, Daniela M. Dinulescu and Bing Xu

      Version of Record online: 24 FEB 2017 | DOI: 10.1002/adhm.201601400

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      A novel process—enzyme-instructed self-assembly (EISA)—to kill cancer cells selectively is reported. We designed two precursors that became self-assembling molecules upon the catalysis of carboxylesterases (CES)–a type of enzyme overexpressed in cancer cells. By amplifying the enzymatic difference between cancer and normal cells, this work provided a new approach for cancer therapy.

    2. Bacterial Interactions with Immobilized Liquid Layers

      Yevgen Kovalenko, Irini Sotiri, Jaakko V. I. Timonen, Jonathan C. Overton, Gareth Holmes, Joanna Aizenberg and Caitlin Howell

      Version of Record online: 8 DEC 2016 | DOI: 10.1002/adhm.201600948

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      The number of bacterial cells adherent on an immobilized liquid layer of silicone oil is significantly affected by the presence or absence of orbital flow, the species of bacteria, and the bacterial cell morphology. In all tested experimental conditions, however, immobilized liquid layers show superior resistance to irreversible bacterial adhesion compared to equivalent solid polydimethylsiloxane surfaces.

    3. Small Subcompartmentalized Microreactors as Support for Hepatocytes

      Yan Zhang, Marie Baekgaard-Laursen and Brigitte Städler

      Version of Record online: 30 NOV 2016 | DOI: 10.1002/adhm.201601141

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      Hepatic bionic tissue is assembled using hepatocytes and sub 10 µm sized core–shell or capsosome-based microreactors. Positive surface charge shows the best integration of the synthetic entities in the proliferating tissue. Upon stressing the bionic tissue with hydrogen peroxide, core–shell microreactors loaded with catalase can alleviate the pressure and improve the viability to the hepatocytes.

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