Advanced Healthcare Materials

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Recently Published Articles

  1. Dynamic Nano-Interfaces Enable Harvesting of Functional 3D-Engineered Tissues

    Akihiro Nishiguchi, Michiya Matsusaki, Shigeru Miyagawa, Yoshiki Sawa and Mitsuru Akashi

    Article first published online: 27 FEB 2015 | DOI: 10.1002/adhm.201500065

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    Functional 3D-engineered tissues are successfully harvested from a substrate using stimuli-responsive hydrogel films with dynamic nano-interface. The dynamic wettability control at the interfaces allows cellular detachment, leading to tissue harvesting without serious damage and remaining polymers. This method can be applied to various types of organs and used for tissue transplantation in regenerative medicine.

  2. Microneedle Biosensor for Real-Time Electrical Detection of Nitric Oxide for In Situ Cancer Diagnosis During Endomicroscopy

    Do Hee Keum, Ho Sang Jung, Taejun Wang, Myeong Hwan Shin, Young-Eun Kim, Ki Hean Kim, G-One Ahn and Sei Kwang Hahn

    Article first published online: 27 FEB 2015 | DOI: 10.1002/adhm.201500012

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    A dual-diagnostic system of endom­icroscope and microneedle sensor is developed to demonstrate high-resolution imaging combined with electrical real-time detection of NO released from cancer tissues. The dual-diagnostic system can be a new platform for facile, precise, rapid, and accurate detection of cancers in various biomedical applications.

  3. NIR-Triggered Drug Delivery by Collagen-Mediated Second Harmonic Generation

    Aoune Barhoumi, Borja Salvador-Culla and Daniel S. Kohane

    Article first published online: 27 FEB 2015 | DOI: 10.1002/adhm.201400768

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    Second harmonic generation is a process through which nonlinear materials such as collagen can absorb two photons and scatter one with twice the energy. Collagen upconverts 730 nm (near-IR) to 365 nm (UV) through second harmonic generation, which cleaves a molecule bound to collagen via a UV-sensitive linker.

  4. Additively Manufactured Device for Dynamic Culture of Large Arrays of 3D Tissue Engineered Constructs

    Pedro F. Costa, Dietmar W. Hutmacher, Christina Theodoropoulos, Manuela E. Gomes, Rui L. Reis and Cédryck Vaquette

    Article first published online: 26 FEB 2015 | DOI: 10.1002/adhm.201400591

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    This study demonstrates the utilization of additive manufacturing to simultaneously manufacture a multichamber perfusion culture device and arrays of 3D scaffolds readily enclosed within. Such device enables surface modification, seeding, and culture of cells onto the inner scaffolds. Given its versatility and scalability, the employed methodology may in the future lead to high levels of automation in tissue engineering strategies.

  5. Mild Hyperthermia Enhances Transport of Liposomal Gemcitabine and Improves In Vivo Therapeutic Response

    Dickson K. Kirui, Christian Celia, Roberto Molinaro, Shyam S. Bansal, Donato Cosco, Massimo Fresta, Haifa Shen and Mauro Ferrari

    Article first published online: 26 FEB 2015 | DOI: 10.1002/adhm.201400738

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    This team reports on successful utility of gold nanorod-mediated mild hyperthermia (MHT) therapy to prime tumor microenvironment, improve vascular transport, and enhance delivery, and efficacy of gemcitabine. Combinational treatment leads to a twofold increase in therapeutic efficacy and inhibition of CAPAN-1 tumor growth, which is directly correlated to the increase in intratumor gemcitabine concentration.