Copyright © 2015 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
April 02, 2015
ChemPlusChem 4/2015: Applications in Medicine
Reseach with potential medicinal applications, in the broadest sense, set an unexpected accent in this issue. Narinder Singh reports the nanomolar detection of iodine in aqueous medium and also in urine samples based on the selective recognition behavior of a gold--organic nanoparticle sensor. Chelator-appended cyclodextrin derivatives devised by Gzaziella Vecchio show potential for the treatment of metal-associated neurogenerative diseases. In the research featured on the front cover Giuliano Giambastiani prepared a hetero-bifunctional cross-linker to decorate carbon nanotubes; these in turn can act as nanocarriers for potential biological probes (cover profile).
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Recently Published Articles
- Targeted Delivery of Fluorescent High-Mannose-Type Oligosaccharide Cathepsin Inhibitor Conjugates
Chung S. Wong, Dr. Sascha Hoogendoorn, Prof. Dr. Gijs A. van der Marel, Prof. Dr. Herman S. Overkleeft and Dr. Jeroen D. C. Codée
Article first published online: 21 APR 2015 | DOI: 10.1002/cplu.201500004
Manno, manno! Fluorescent glycoconjugates composed of a peptide epoxysuccinate coupled via a BODIPY dye to oligomannosides (see figure) show mannose-receptor-dependent uptake and ensuing cathepsin inhibition in live dendritic cells. The size of the mannose oligosaccharides proved to influence the amount of inhibition.
- Luminescent Mesoporous Silica Built through Self-Assembly of Polyhedral Oligomeric Silsesquioxane and Europium(III) Ions
Stefano Marchesi, Dr. Fabio Carniato, Prof. Leonardo Marchese and Dr. Enrico Boccaleri
Article first published online: 21 APR 2015 | DOI: 10.1002/cplu.201500143
Pore Eu: The assembly of completely condensed octa(tetramethylammonium)-functionalized polyhedral oligomeric silsesquioxanes and Eu3+ ions leads to a novel luminescent hierarchical mesoporous silica with high surface area, good hydrothermal stability, and interesting optical properties (see figure). This material is a promising multifunctional platform for bio-imaging and optoelectronic applications.
- Dispersion of Synthetic MoS2 Flakes and Their Spontaneous Adsorption on Single-Walled Carbon Nanotubes
Dr. Yoshiyuki Nonoguchi, Dr. Kenji Hata and Prof. Tsuyoshi Kawai
Article first published online: 20 APR 2015 | DOI: 10.1002/cplu.201500084
Affinity and a mismatch: MoS2 flakes with well-exfoliated structures have been prepared that show high dispersibility in common organic solvents. When MoS2 nanoplates were spontaneously adsorbed onto the surface of single-walled carbon nanotubes (SWNTs), the thermoelectric figure of merit, ZT, increased tenfold (see figure).
- One-Step Electrodeposition of Polyallylamine-Functionalized Gold Nanodendrites and Their Application in Sensing
Dr. Pan Li, Tan Huang, Dr. Jie Yang, Prof. Shaohua Wei, Prof. Chenxin Cai, Prof. Yu Chen and Prof. Jong-Min Lee
Article first published online: 17 APR 2015 | DOI: 10.1002/cplu.201500072
Iodate detection: Three-dimensionally polyallylamine-functionalized gold nanodendrites are successfully synthesized by a simple one-step electrodeposition method. This can effectively immobilize the RuIII ion through coordination interactions between RuIII ion and polyallylamine and the resulting electrode shows excellent electrocatalytic activity towards iodate reduction.
- Is TiO2(B) the Future of Titanium-Based Battery Materials?
Dr. Marcus Fehse and Dr. Edgar Ventosa
Article first published online: 15 APR 2015 | DOI: 10.1002/cplu.201500038
Pushing the envelope: The monoclinic TiO2 bronze phase, often referred to as TiO2(B), holds great promise for applications in Li-ion and Na-ion batteries. Strategies for further improvement may result in high-energy-density materials suitable for application in full electric vehicles.