Fluorescent Nanodiamonds with Bioorthogonally Reactive Protein-Resistant Polymeric Coatings
Dr. Ivan Rehor, Dr. Hana Mackova, Dr. Sergey K. Filippov, Dr. Jan Kucka, Dr. Vladimir Proks, Jitka Slegerova, Dr. Stuart Turner, Prof. Gustaaf Van Tendeloo, Dr. Miroslav Ledvina, Dr. Martin Hruby and Dr. Petr Cigler
Article first published online: 5 DEC 2013 | DOI: 10.1002/cplu.201300395
The back cover picture shows fluorescent, near-IR-emitting diamond nanoparticles coated with a biocompatible polymer interface. The coating is partially peeled off from the particle to reveal the layered structure. First, an ultrathin silica layer is attached to the diamond core. The copolymer chains formed from N-(2-hydroxypropyl)methacrylamide and alkyne-containing methacrylamide monomer are grafted from the silica layer. In their Full Paper (DOI: 10.1002/cplu.201300395), P. Cigler and co-workers show that thanks to their superior colloidal stability, the nanoparticles can be dissolved in an aqueous buffer of high ionic strength. The coating is translucent, and moreover, it is protein-resistant: it protects the particles against nonspecific protein adsorption.