Asian Journal of Organic Chemistry
Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Recently Published Issues
January 20, 2014
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Recently Published Articles
- Phase-Transfer-Catalyzed Asymmetric α-Arylation of α-Amino Acid Derivatives
Dr. Seiji Shirakawa, Kenichiro Yamamoto, Takashi Tokuda and Prof. Dr. Keiji Maruoka
Article first published online: 5 MAR 2014 | DOI: 10.1002/ajoc.201400004
Set phasers to transfer: Highly enantioselective α-arylation of α-amino acid derivatives was achieved under phase-transfer conditions. This reaction demonstrates a valuable method for the catalytic asymmetric synthesis of α,α-disubstituted α-amino acids containing an aromatic substituent. PTC=phase-transfer catalyst; Tf=trifluoromethanesulfonyl.
- Asymmetric Synthesis of Tetrahydroquinolines via Saegusa-type Oxidative Enamine Catalysis/1,5-Hydride Transfer/Cyclization Sequences
Chang Won Suh, Saet Byeol Woo and Prof. Dr. Dae Young Kim
Article first published online: 5 MAR 2014 | DOI: 10.1002/ajoc.201400022
Enamine catalysis you Sae? The organocatalytic Saegusa-type oxidative enamine catalysis/1,5-hydride transfer/ring closure reaction is described. This neutral reaction cascade allows for the efficient formation of ring-fused tetrahydroquinolines in high enantioselectivity. DNBS=2,4-dinitrobenzensulfonic acid; TMS=trimethylsilyl.
- Organocatalytic Enantio- and Diastereoselective Assembly of Thiazolidine Scaffolds by Formal [3+2] Annulation
Hui Qian and Prof. Jianwei Sun
Article first published online: 5 MAR 2014 | DOI: 10.1002/ajoc.201400025
Great balls of thia: An organocatalytic formal [3+2] annulation is described. With readily available achiral starting materials, a range of thiazolidines can be assembled in excellent yield and with moderate to good enantioselectivity and diastereoselectivity.
- An Organocatalytic Addition of Nitromethane to Activated Ketimines
Yu-Hui Wang, Yun-Lin Liu, Zhong-Yan Cao and Prof. Dr. Jian Zhou
Article first published online: 3 MAR 2014 | DOI: 10.1002/ajoc.201300289
Adding up: We report an organocatalytic addition of nitromethane to aryl α-ketoester-derived N-tosyl (Ts) ketimines 2 or isatin-derived N-tert-butyloxycarbonyl (Boc) ketimines catalyzed by 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU). Initial asymmetric studies resulted in up to 71 % ee for product 5 a.
- N-Heterocyclic Carbene-Catalyzed [3+3] Cyclocondensation of Bromoenals and Ketimines: Highly Enantioselective Synthesis of Dihydropyridinones
Han-Ming Zhang, Wen-Qiang Jia, Zhi-Qin Liang and Prof. Dr. Song Ye
Article first published online: 3 MAR 2014 | DOI: 10.1002/ajoc.201400010
Not Half Clever: The N-heterocyclic carbene (NHC)-catalyzed [3+3] cyclocondensation of bromoenals and cyclic imines was developed. The reaction works well with both acyclic and cyclic ketimines to give the corresponding chiral dihydropyridinones in good yields with high enantioselectivity.