Arthritis & Rheumatology

Cover image for Vol. 68 Issue 8

Accepted Articles (Accepted, unedited articles published online and citable. The final edited and typeset version of record will appear in future.)

Edited By: Richard J. Bucala, MD, PhD

Online ISSN: 2326-5205

Associated Title(s): Arthritis Care & Research

VIEW

  1. 1 - 100
  2. 101 - 122
  1. Full Length

    1. The regulatory B cell compartment expands transiently during childhood and is contracted in children with autoimmunity

      Ioannis Kalampokis, Guglielmo M. Venturi, Jonathan C. Poe, Jeffrey A. Dvergsten, John W. Sleasman and Thomas F. Tedder

      Accepted manuscript online: 18 JUL 2016 10:41AM EST | DOI: 10.1002/art.39820

    2. Tofacitinib ameliorates murine lupus and its associated vascular dysfunction

      Yasuko Furumoto, Carolyne K. Smith, Luz Blanco, Wenpu Zhao, Stephen R. Brooks, Seth G. Thacker, Zarzour Abdalrahman, Giuseppe Sciumè, Wanxia L. Tsai, Anna M. Trier, Leti Nunez, Laurel Mast, Victoria Hoffmann, Alan T. Remaley, John J. O'Shea, Mariana J. Kaplan and Massimo Gadina

      Accepted manuscript online: 18 JUL 2016 10:41AM EST | DOI: 10.1002/art.39818

    3. Platelets induce thymic stromal lymphopoietin production by endothelial cells: Contribution to human systemic sclerosis fibrosis

      Marie-Elise Truchetet, Béatrice Demoures, Jorge E. Guimaraes, Anne Bertrand, Paôline Laurent, Valérie Jolivel, Isabelle Douchet, Clément Jacquemin, Liliane Khoryati, Pierre Duffau, Estibaliz Lazaro, Christophe Richez, Julien Seneschal, Marie-Sylvie Doutre, Jean-Luc Pellegrin, Joël Constans, Thierry Schaeverbeke, Patrick Blanco, Cécile Contin-Bordes and on behalf of the FHU ACRONIM

      Accepted manuscript online: 18 JUL 2016 10:40AM EST | DOI: 10.1002/art.39817

  2. Review Article

    1. Novel insights into TNF receptor, DR3 and progranulin pathways in arthritis and bone remodeling

      Anwen Williams, Eddie C. Y. Wang, Lorenz Thurner and Chuan-ju Liu

      Accepted manuscript online: 18 JUL 2016 10:40AM EST | DOI: 10.1002/art.39816

  3. Editorial

    1. Closing in on the role of TSLP inhibition as a therapeutic entry point for systemic sclerosis

      Alsya A. Affandi and Joel A.G. van Roon

      Accepted manuscript online: 18 JUL 2016 10:40AM EST | DOI: 10.1002/art.39815

  4. Full Length

    1. The association of serum calprotectin (S100A8/S100A9) levels with disease relapses in PR3-ANCA-associated vasculitis

      Ruth J. Pepper MBBS, Juliana B. Draibe, Ben Caplin, Fernando C. Fervenza, Gary S. Hoffman, Cees G.M. Kallenberg, Carol A. Langford, Paul A. Monach, Philip Seo, Robert Spiera, E. William St Clair, Nadia K. Tchao, John H. Stone, Ulrich Specks, Peter A. Merkel, A.D. Salama and RAVE-ITN Research Group

      Accepted manuscript online: 18 JUL 2016 10:40AM EST | DOI: 10.1002/art.39814

    2. Myeloperoxidase-ANCA-Positive and ANCA-Negative Patients With Granulomatosis With Polyangiitis: Distinct Patient Subsets

      E.M. Miloslavsky, N. Lu, S. Unizony, H.K. Choi, P.A. Merkel, P. Seo, R. Spiera, C.A. Langford, G.S Hoffman, C.G.M. Kallenberg, E.W. St. Clair, N.K. Tchao, F. Fervenza, P.A. Monach, U. Specks and J.H. Stone

      Accepted manuscript online: 18 JUL 2016 10:39AM EST | DOI: 10.1002/art.39812

  5. Brief Reports

    1. Altered Innate Lymphoid Cells subsets in human lymph node biopsies during the at risk and earliest phase of rheumatoid arthritis

      Javier Rodríguez-Carrio, Janine S. Hähnlein, Tamara H. Ramwadhdoebe, Johanna F. Semmelink, Ivy Y. Choi, Krijn P. van Lienden, Mario Maas, Danielle M. Gerlag, Paul P. Tak, Teunis B. H. Geijtenbeek and Lisa G. M. van Baarsen

      Accepted manuscript online: 18 JUL 2016 10:38AM EST | DOI: 10.1002/art.39811

  6. Full Length

    1. Tartrate-Resistant Acid Phosphatase Deficiency in the Predisposition to Systemic Lupus Erythematosus

      Jie An, Tracy A Briggs, Audrey Dumax-vorzet, Marta E Alarcón-Riquelme, Alexandre Belot, Michael Beresford, Ian Bruce, Claudia Carvalho, Laurence Chaperot, Johan Frostegård, Joel Plumas, Gillian I Rice, Timothy J Vyse, Alice Wiedeman, Yanick J Crow and Keith B Elkon

      Accepted manuscript online: 7 JUL 2016 09:39AM EST | DOI: 10.1002/art.39810

    2. Post-hoc analysis of the Phase II/III APRIL-SLE study: Association between response to atacicept and serum biomarkers including BLyS and APRIL

      Caroline Gordon, David Wofsy, Stephen Wax, Yong Li, Claudia Pena Rossi and David Isenberg

      Accepted manuscript online: 7 JUL 2016 09:39AM EST | DOI: 10.1002/art.39809

    3. You have full text access to this OnlineOpen article
      A Randomized Phase 2b Study of ABT-494, a Selective JAK1 Inhibitor in Patients with Rheumatoid Arthritis and an Inadequate Response to Methotrexate

      Mark C. Genovese, Josef S. Smolen, Michael E. Weinblatt, Gerd R. Burmester, Sebastian Meerwein, Heidi S. Camp, Li Wang, Ahmed A. Othman, Nasser Khan, Aileen L. Pangan and Steven Jungerwirth

      Accepted manuscript online: 7 JUL 2016 09:38AM EST | DOI: 10.1002/art.39808

  7. Editorial

    1. You have full text access to this OnlineOpen article
      Can Prevotella copri Be a Causative Pathobiont in Rheumatoid Arthritis?

      Donghyun Kim and Wan-Uk Kim

      Accepted manuscript online: 7 JUL 2016 09:38AM EST | DOI: 10.1002/art.39807

  8. Full Length

    1. You have full text access to this OnlineOpen article
      Effect of secukinumab on patient-reported outcomes in patients with active ankylosing spondylitis: A Phase 3 randomized trial (MEASURE 1)

      A Deodhar, M Dougados, D Baeten, C Wei, P Geusens, A Readie, H Richards, R Martin and B Porter

      Accepted manuscript online: 7 JUL 2016 09:38AM EST | DOI: 10.1002/art.39805

  9. Editorial

    1. Subduing Lupus: Can Preclinical Autoimmune Disease Be Arrested?

      Heather M. Berens-Norman and Susan A. Boackle

      Accepted manuscript online: 7 JUL 2016 09:37AM EST | DOI: 10.1002/art.39804

  10. Brief Reports

    1. Vitamin D Deficiency Is Associated With Endothelial Dysfunction and Increases Type-1 Interferon Gene Expression in a Murine Model of SLE

      John A Reynolds, Avi Z Rosenberg, Carolyne K Smith, Jamie C Sergeant, Gillian I Rice, Tracy A Briggs, Ian N Bruce and Mariana J Kaplan

      Accepted manuscript online: 7 JUL 2016 09:37AM EST | DOI: 10.1002/art.39803

    2. Dialister as microbial marker of disease activity in spondyloarthritis

      Raul Y. Tito, Heleen Cypers, Marie Joossens, Gaëlle Varkas, Liesbet Van Praet, Elien Glorieus, Filip Van den Bosch, Martine De Vos, Jeroen Raes and Dirk Elewaut

      Accepted manuscript online: 7 JUL 2016 09:37AM EST | DOI: 10.1002/art.39802

  11. Full Length

    1. You have full text access to this OnlineOpen article
      A Phase 2b Study of ABT-494, a Selective JAK1 Inhibitor, in Patients With Rheumatoid Arthritis and an Inadequate Response to Anti–TNF Therapy

      Joel M. Kremer, Paul Emery, Heidi S. Camp, Alan Friedman, Li Wang, Ahmed A. Othman, Nasser Khan, Aileen L. Pangan, Steven Jungerwirth and Edward C. Keystone

      Accepted manuscript online: 7 JUL 2016 09:37AM EST | DOI: 10.1002/art.39801

  12. Brief Reports

    1. C-X-C Motif Chemokine 10 is a Possible Biomarker for the Development of Psoriatic Arthritis among Patients with Psoriasis

      Fatima Abji, Remy A. Pollock, Kun Liang, Vinod Chandran and Dafna D. Gladman

      Accepted manuscript online: 7 JUL 2016 09:37AM EST | DOI: 10.1002/art.39800

  13. Review Articles

    1. Gout: A roadmap to approaches for improving global outcomes

      Nicola Dalbeth, Hyon K. Choi and Robert Terkeltaub

      Accepted manuscript online: 7 JUL 2016 09:37AM EST | DOI: 10.1002/art.39799

  14. Brief Reports

    1. Power Doppler ultrasonography for detection of increased vascularity in the fascia: A potential early diagnostic tool in fasciitis of dermatomyositis

      Ken Yoshida, Makiko Nishioka, Satoshi Matsushima, Kensuke Joh, Yosuke Oto, Masayuki Yoshiga, Kazuhiro Otani, Haruyasu Ito, Kenichiro Hirai, Kazuhiro Furuya, Taro Ukichi, Kentaro Noda, Isamu Kingetsu and Daitaro Kurosaka

      Accepted manuscript online: 7 JUL 2016 09:37AM EST | DOI: 10.1002/art.39798

  15. Full Length

    1. An Autotaxin-LPA-IL-6 Amplification Loop Drives Scleroderma Fibrosis

      Flavia V. Castelino, Gretchen Bain, Veronica A. Pace, Katharine E. Black, Leaya George, Clemens K. Probst, Lance Goulet, Robert Lafyatis and Andrew M. Tager

      Accepted manuscript online: 7 JUL 2016 09:37AM EST | DOI: 10.1002/art.39797

    2. Long interspersed nuclear element-1 retroelements are expressed in patients with systemic autoimmune disease and induce type I interferon

      Clio P. Mavragani, Irina Sagalovskiy, Qiu Guo, Adrianos Nezos, Efstathia K. Kapsogeorgou, Pin Lu, Jun Liang Zhou, Kyriakos A. Kirou, Surya V. Seshan, Haralampos M. Moutsopoulos and Mary K. Crow

      Accepted manuscript online: 24 JUN 2016 05:01AM EST | DOI: 10.1002/art.39795

  16. Editorial

    1. LINEing Up to Boost Interferon Production: Activation of Endogenous Retroviral DNA in Autoimmunity

      Andras Perl

      Accepted manuscript online: 24 JUN 2016 05:01AM EST | DOI: 10.1002/art.39794

  17. Full Length

    1. Human Gut-Derived Prevotella histicola Suppresses Inflammatory Arthritis in Humanized Mice

      Eric V. Marietta, Joseph A. Murray, David H. Luckey, Patricio R. Jeraldo, Abhinav Lamba, Robin Patel, Harvinder S. Luthra, Ashutosh Mangalam and Veena Taneja

      Accepted manuscript online: 23 JUN 2016 09:32AM EST | DOI: 10.1002/art.39785

    2. Outcome and trends in treatment of systemic juvenile idiopathic arthritis in the German National Pediatric Rheumatological Database from 2000 to 2013

      Jens Klotsche, Anna Raab, Martina Niewerth, Claudia Sengler, Gerd Ganser, Tilmann Kallinich, Tim Niehues, Markus Hufnagel, Angelika Thon, Toni Hospach, Gerd Horneff and Kirsten Minden

      Accepted manuscript online: 22 JUN 2016 11:15AM EST | DOI: 10.1002/art.39796

    3. Clinical and genetic features of patients with TNFRSF1A variants in Japan: Findings of a nationwide survey

      Naoyasu Ueda, Hiroaki Ida, Masakazu Washio, Hisaaki Miyahara, Shoji Tokunaga, Fumiko Tanaka, Hiroki Takahashi, Koichi Kusuhara, Koichiro Ohmura, Manabu Nakayama, Osamu Ohara, Ryuta Nishikomori, Seiji Minota, Shuji Takei, Takao Fujii, Yoshiaki Ishigatsubo, Hiroshi Tsukamoto, Tomoko Tahira and Takahiko Horiuchi

      Accepted manuscript online: 22 JUN 2016 11:14AM EST | DOI: 10.1002/art.39793

    4. Epigenetic signatures of salivary gland inflammation in sjögren's syndrome

      Michael B. Cole, Hong Quach, Diana Quach, Baker Alice, Kimberly E. Taylor, Lisa F. Barcellos and Lindsey A. Criswell

      Accepted manuscript online: 22 JUN 2016 11:14AM EST | DOI: 10.1002/art.39792

    5. You have full text access to this OnlineOpen article
      Mitochondrial dysfunction in the liver and antiphospholipid antibody production precede disease onset and respond to rapamycin in lupus-prone mice

      Zachary Oaks, Thomas Winans, Tiffany Caza, David Fernandez, Yuxin Liu, Steve K. Landas, Katalin Banki and Andras Perl

      Accepted manuscript online: 22 JUN 2016 11:14AM EST | DOI: 10.1002/art.39791

    6. Relapsing polychondritis can be characterized by 3 different clinical phenotypes: Analysis of a recent series of 142 patients

      Jérémie Dion, Nathalie Costedoat-Chalumeau, Damien Sène, Judith Cohen-Bittan, Gaëlle Leroux, Charlotte Dion, Camille Francès and Jean-Charles Piette

      Accepted manuscript online: 22 JUN 2016 11:14AM EST | DOI: 10.1002/art.39790

  18. Editorial

    1. IgA responses and future development of Rheumatoid Arthritis

      Ignacio Sanz

      Accepted manuscript online: 22 JUN 2016 11:14AM EST | DOI: 10.1002/art.39789

  19. Letter to the Editor

    1. Primary or secondary effect of quadriceps exercises on subsequent need for knee replacement?

      Bruce Rothschild

      Accepted manuscript online: 22 JUN 2016 11:14AM EST | DOI: 10.1002/art.39788

  20. Reply to Letter to the Editor

    1. Reply to letter to the editor: “Primary or secondary effect of quadriceps exercises on subsequent need for knee replacement?”

      Adam G. Culvenor, Wolfgang Wirth, Anja Ruhdorfer and Felix Eckstein

      Accepted manuscript online: 22 JUN 2016 11:09AM EST | DOI: 10.1002/art.39787

  21. Full Length

    1. Myeloperoxidase-ANCA associated Granulomatosis with polyangiitis is a clinically distinct subset within ANCA-associated vasculitis

      Jan H. Schirmer, Marvin N. Wright, Kristine Herrmann, Martin Laudien, Bernhard Nölle, Eva Reinhold-Keller, Jan P. Bremer, Frank Moosig and Julia U. Holle

      Accepted manuscript online: 22 JUN 2016 11:09AM EST | DOI: 10.1002/art.39786

    2. Secretory Activity of Neutrophils Correlates With Genotype in Familial Mediterranean Fever

      Faekah Gohar, Banu Orak, Tilmann Kallinich, Marion Jeske, Mareike Lieber, Horst von Bernuth, Arnd Giese, Elisabeth Weissbarth-Riedel, Johannes-Peter Haas, Frank Dressler, Dirk Holzinger, Peter Lohse, Ulrich Neudorf, Elke Lainka, Claas Hinze, Katja Masjosthusmann, Christoph Kessel, Toni Weinhage, Dirk Foell and Helmut Wittkowski

      Accepted manuscript online: 22 JUN 2016 11:09AM EST | DOI: 10.1002/art.39784

    3. Dysbiosis contributes to arthritis development via activation of autoreactive T cells in the intestine

      Yuichi Maeda, Takashi Kurakawa, Eiji Umemoto, Daisuke Motooka, Yoshinaga Ito, Kazuyoshi Gotoh, Keiji Hirota, Masato Matsushita, Yoki Furuta, Masashi Narazaki, Noriko Sakaguchi, Hisako Kayama, Shota Nakamura, Tetsuya Iida, Yukihiko Saeki, Atsushi Kumanogoh, Shimon Sakaguchi and Kiyoshi Takeda

      Accepted manuscript online: 22 JUN 2016 11:08AM EST | DOI: 10.1002/art.39783

  22. Clinical Image

    1. Pseudo-Pelger-Huёt anomaly in systemic lupus erythematosus

      Wan Yin Yeung and Chi Chiu Mok

      Accepted manuscript online: 22 JUN 2016 11:08AM EST | DOI: 10.1002/art.39782

  23. Full Length

    1. A novel mechanism for generating the interferon signature in lupus: opsonization of dead cells by complement and IgM

      Haoyang Zhuang, Shuhong Han, Yi Li, Deborah Kienhöfer, Pui Lee, Stepan Shumyak, Richard Meyerholz, Krzysztof Rosadzinski, Danielle Rosner, Annie Chan, Yuan Xu, Mark Segal, Eric Sobel, Li-Jun Yang, Markus H. Hoffmann and Westley H. Reeves

      Accepted manuscript online: 6 JUN 2016 08:01AM EST | DOI: 10.1002/art.39781

    2. HLA-DRB1 amino acid positions 11/13, 71 and 74 are associated with inflammation level, disease activity and the Health Assessment Questionnaire disability index in patients with inflammatory polyarthritis

      Stephanie F. Ling, Sebastien Viatte, Mark Lunt, Alper M. Van Sijl, Lucia Silva-Fernandez, Deborah P.M. Symmons, Adam Young, Alexander J. Macgregor and Anne Barton

      Accepted manuscript online: 6 JUN 2016 08:01AM EST | DOI: 10.1002/art.39780

  24. Letter to the Editor

    1. “Ultrasound as timely investigation to refer to chest computer tomography in systemic sclerosis”

      Marco Sperandeo, Vincenzo Carnevale and Maria Arcangela Grimaldi

      Accepted manuscript online: 6 JUN 2016 08:00AM EST | DOI: 10.1002/art.39779

    2. Pulmonary function parameters other than vital capacity should be considered for the screening of interstitial lung disease in systemic sclerosis: Comment on the article by Suliman et al.

      Bruno Degano, Thibaud Soumagne, Guillaume Eberst, Nadine Méaux-Ruault, Helder Gil and Nadine Magy-Bertrand

      Accepted manuscript online: 6 JUN 2016 08:00AM EST | DOI: 10.1002/art.39778

  25. Clinical Image

    1. IgG4-related disease with an aorto-duodenal fistula after abdominal aortic aneurysm repair

      Kunihiro Ichinose, Saeko Araki, Ayuko Takatani, Tomonori Tanaka and Atsushi Kawakami

      Accepted manuscript online: 6 JUN 2016 08:00AM EST | DOI: 10.1002/art.39777

  26. Brief Reports

    1. Management of Chronic Post-Chikungunya Rheumatic Disease: The Martinican Experience

      Marie Blettery, Lauren Brunier, Kathleen Polomat, Florence Moinet, Christophe Deligny, Serge Arfi, Georges Jean-Baptiste and Michel De Bandt

      Accepted manuscript online: 6 JUN 2016 08:00AM EST | DOI: 10.1002/art.39775

  27. Full Length

    1. Statins and Risk of Rheumatoid Arthritis - A Nested Case-Control Study

      Koray Tascilar, Sophie Dell'Aniello, Marie Hudson and Samy Suissa

      Accepted manuscript online: 6 JUN 2016 07:59AM EST | DOI: 10.1002/art.39774

    2. IgG4-related disease is associated with a history of malignancy

      Zachary S. Wallace, Carly J. Wallace, Na Lu, Hyon K. Choi and John H. Stone

      Accepted manuscript online: 6 JUN 2016 07:59AM EST | DOI: 10.1002/art.39773

    3. Effect of comedication with conventional synthetic DMARDs on TNF inhibitors-retention in patients with spondyloarthritis: A prospective cohort

      Alexandre Sepriano, Sofia Ramiro, Désirée van der Heijde, Pedro Ávila-Ribeiro, Rita Fonseca, Joana Borges, Lídia Teixeira, Pedro Carvalho, Marcos Cerqueira, Joana Neves, Tiago Meirinhos, Anabela Barcelos, Graça Sequeira, Maria João Salvador, José António Canas da Silva, Helena Santos, Miguel Bernardes, Elsa Vieira-Sousa, Helena Canhão, Jaime C. Branco, Fernando Pimentel-Santos and Robert Landewé

      Accepted manuscript online: 6 JUN 2016 07:59AM EST | DOI: 10.1002/art.39772

    4. IgA Plasmablasts are Elevated in Subjects At Risk for Future Rheumatoid Arthritis

      Jennifer D. Kinslow, Lisa K. Blum, Kevin D. Deane, M. Kristen Demoruelle, Yuko Okamoto, Mark Parish, Sarah Kongpachith, Lauren J. Lahey, Jill M. Norris, William H. Robinson and V. Michael Holers

      Accepted manuscript online: 6 JUN 2016 07:59AM EST | DOI: 10.1002/art.39771

  28. Brief Reports

    1. Late onset cryopyrin-associated periodic syndrome due to myeloid-restricted somatic NLRP3 mosaicism

      Anna Mensa-Vilaro, María Teresa Bosque, Giuliana Magri, Yoshitaka Honda, Helios Martínez-Banaclocha, Marta Casorran-Berges, Jordi Sintes, Eva González-Roca, Estibaliz Ruiz-Ortiz, Toshio Heike, Juan J. Martínez-Garcia, Alberto Baroja-Mazo, Andrea Cerutti, Ryuta Nishikomori, Jordi Yagüe, Pablo Pelegrín, Concha Delgado-Beltran and Juan I. Aróstegui

      Accepted manuscript online: 6 JUN 2016 07:59AM EST | DOI: 10.1002/art.39770

  29. Letter to the Editor

    1. Febuxostat for patients with gout and severe chronic kidney disease: which is the appropriate dosage? Comment on the article by Saag et al.

      Neus Quilis, Mariano Andrés, Susana Gil, Laura Ranieri, Paloma Vela and Eliseo Pascual

      Accepted manuscript online: 6 JUN 2016 07:58AM EST | DOI: 10.1002/art.39769

  30. Reply to Letter to the Editor

    1. Response to Letter from Dr. Quilis and colleagues

      Kenneth Saag and Lhanoo Gunawardhana

      Accepted manuscript online: 6 JUN 2016 07:58AM EST | DOI: 10.1002/art.39768

  31. Brief Reports

    1. Trends in Hospitalizations Due to Acute Coronary Syndromes and Stroke in Patients with Systemic Lupus Erythematosus, 1996 To 2012

      Maria G. Tektonidou, Zhong Wang and Michael M. Ward

      Accepted manuscript online: 6 JUN 2016 07:57AM EST | DOI: 10.1002/art.39758

    2. Anti-Eukaryotic Initiation Factor 2B Autoantibodies are Associated with Interstitial Lung Disease in Patients with Systemic Sclerosis

      Zoe E. Betteridge, Felix Woodhead, Hui Lu, Gavin Shaddick, Christopher C. Bunn, Christopher P. Denton, David J. Abraham, Roland M. du Bois, Mervyn Lewis, Athol U. Wells and Neil J. McHugh

      Accepted manuscript online: 6 JUN 2016 07:57AM EST | DOI: 10.1002/art.39755

  32. Full Length

    1. Myeloid-derived suppressor cells induce the expansion of regulatory B cells and ameliorate autoimmunity in Roquinsan/san mice, one of murine models of SLE

      Min-Jung Park, Sung-Hee Lee, Eun-Kyung Kim, Eun-Jung Lee, Sung-Hwan Park, Seung-Ki Kwok and Mi-La Cho

      Accepted manuscript online: 23 MAY 2016 02:40PM EST | DOI: 10.1002/art.39767

    2. Clinical and imaging signs of spondyloarthritis in first-degree relatives of HLA-B27 positive ankylosing spondylitis patients: The pre-spondyloarthritis (Pre-SpA) cohort

      Maureen C. Turina, Janneke J. de Winter, Jacky E. Paramarta, Mihaela Gamala, Nataliya Yeremenko, Marita N. Nabibux, Robert Landewé and Dominique L. Baeten

      Accepted manuscript online: 23 MAY 2016 02:40PM EST | DOI: 10.1002/art.39766

  33. Brief Reports

    1. HLA DRB1, DQA1 and DQB1 in Juvenile Onset Systemic Sclerosis

      Anne M. Stevens, Sami B. Kanaan, Kathryn S. Torok, Thomas A. Medsger, Maureen D. Mayes, John D. Reveille, Marisa Klein-Gitelman, Ann M. Reed, Tzielan Lee, Suzanne C. Li, Gretchen Henstorf, Christine Luu, Tessa Aydelotte and J. Lee Nelson

      Accepted manuscript online: 23 MAY 2016 02:40PM EST | DOI: 10.1002/art.39765

  34. Editorial

    1. Axial SpA: the recurrence plot thickens

      Ismail Sari and Nigil Haroon

      Accepted manuscript online: 23 MAY 2016 02:40PM EST | DOI: 10.1002/art.39764

  35. Full Length

    1. The phenotype and genotype of mevalonate kinase deficiency: A series of 114 cases from the Eurofever Registry

      Nienke M. ter Haar, Jerold Jeyaratnam, Helen J. Lachmann, Anna Simon, Paul A. Brogan, Matteo Doglio, Marco Cattalini, Jordi Anton, Consuelo Modesto, Pierre Quartier, Esther Hoppenreijs, Silvana Martino, Antonella Insalaco, Luca Cantarini, Loredana Lepore, Maria Alessio, Inmaculada Calvo Penades, Christina Boros, Rita Consolini, Donato Rigante, Ricardo Russo, Jana Pachlopnik Schmid, Thirusha Lane, Alberto Martini, Nicolino Ruperto, Joost Frenkel, Marco Gattorno and for the Paediatric Rheumatology International Trials Organisation (PRINTO) and Eurofever Project.

      Accepted manuscript online: 23 MAY 2016 02:40PM EST | DOI: 10.1002/art.39763

    2. Risk of Myocardial Infarction and Stroke in Patients with Granulomatosis with Polyangiitis: A Population-Based Study

      J. Antonio Aviña-Zubieta, Alice Mai, Neda Amiri, Natasha Dehghan, Ju Ann Tan, Eric C. Sayre and Hyon K. Choi

      Accepted manuscript online: 23 MAY 2016 02:40PM EST | DOI: 10.1002/art.39762

  36. Brief Reports

    1. Risk for Gastrointestinal Perforation among Rheumatoid Arthritis Patients receiving Tofacitinib, Tocilizumab, or other Biologics

      Fenglong Xie, Huifeng Yun, Sasha Bernatsky and Jeffrey R Curtis

      Accepted manuscript online: 23 MAY 2016 02:40PM EST | DOI: 10.1002/art.39761

  37. Full Length

    1. You have full text access to this OnlineOpen article
      Genetic variation in FOXO3 is associated with reductions in inflammation and disease activity in inflammatory polyarthritis

      Sebastien Viatte, James C. Lee, Bo Fu, Marion Espéli, Mark Lunt, Jack N.E. De Wolf, Lily Wheeler, John A. Reynolds, Madhura Castelino, Deborah P.M. Symmons, Paul A. Lyons, Anne Barton and Kenneth G.C. Smith

      Accepted manuscript online: 23 MAY 2016 02:40PM EST | DOI: 10.1002/art.39760

  38. Review Articles

    1. Long non-coding RNAs in the regulation of inflammatory pathways in rheumatoid arthritis and osteoarthritis

      Mark J. Pearson and Simon W. Jones

      Accepted manuscript online: 23 MAY 2016 02:39PM EST | DOI: 10.1002/art.39759

  39. Full Length

    1. How hand osteoarthritis, comorbidity and pain interact to determine functional limitation in older people: Observations from the eposa study

      Paola Siviero, Sabina Zambon, Federica Limongi, Maria Victoria Castell, Cyrus Cooper, Dorly J.H. Deeg, Michael D. Denkinger, Elaine M. Dennison, Mark H. Edwards, Antonella Gesmundo, Ángel Otero, Nancy L. Pedersen, Richard Peter, Rocio Queipo, Erik J. Timmermans, Natasja M. van Schoor, Stefania Maggi and for the EPOSA Research Group

      Accepted manuscript online: 23 MAY 2016 02:37PM EST | DOI: 10.1002/art.39757

  40. Reply to Letter to the Editor

    1. Mesenchymal stem cell transplantation in systemic sclerosis: Reply to the comment from P Cipriani et al.

      Alexandre TJ Maria, Christian Jorgensen, Alain Le Quellec, Danièle Noël and Philippe Guilpain

      Accepted manuscript online: 23 MAY 2016 02:37PM EST | DOI: 10.1002/art.39756

  41. Letter to the Editor

    1. Mesenchymal stem cells transplantation in Systemic Sclerosis: comment on the article by ATJ Maria et al

      Paola Cipriani, Paola Di Benedetto, Vasiliki Liakouli and Roberto Giacomelli

      Accepted manuscript online: 23 MAY 2016 02:37PM EST | DOI: 10.1002/art.39754

  42. Full Length

    1. Muscle biopsy in combination with myositis-specific autoantibodies aids prediction of outcomes in juvenile dermatomyositis

      Claire T. Deakin, Shireena A. Yasin, Stefania Simou, Katie A. Arnold, Sarah L. Tansley, Zoe E. Betteridge, Neil J. McHugh, Hemlata Varsani, Janice L. Holton, Thomas S. Jacques, Clarissa A. Pilkington, Kiran Nistala, Lucy R. Wedderburn and on behalf of the UK Juvenile Dermatomyositis Research Group

      Accepted manuscript online: 23 MAY 2016 02:37PM EST | DOI: 10.1002/art.39753

  43. Clinical Image

    1. Symphalangism

      Amirala S. Pasha and Melissa Weimer

      Accepted manuscript online: 23 MAY 2016 02:36PM EST | DOI: 10.1002/art.39752

  44. Full Length

    1. You have full text access to this OnlineOpen article
      Changes in Ultrasonographic Vascularity upon Initiation of Adalimumab Combination Therapy in Rheumatoid Arthritis Patients with Inadequate Response to Methotrexate

      Gurjit S. Kaeley, Midori J. Nishio, Janak R. Goyal, Daryl K. MacCarter, Alvin F. Wells, Su Chen, Hartmut Kupper and Jasmina Kalabic

      Accepted manuscript online: 23 MAY 2016 02:36PM EST | DOI: 10.1002/art.39751

    2. Anti-GAPDH autoantibodies as a pathogenic determinant and potential biomarker of neuropsychiatric diseases

      Federica Delunardo, Denise Soldati, Veronica Bellisario, Alessandra Berry, Serena Camerini, Marco Crescenzi, Cristiano Alessandri, Fabrizio Conti, Fulvia Ceccarelli, Ada Francia, Guido Valesini, Francesca Cirulli, Alberto Siracusano, Alessandra Siracusano, Cinzia Niolu, Ivo Alex Rubino, Elena Ortona and Paola Margutti

      Accepted manuscript online: 23 MAY 2016 02:36PM EST | DOI: 10.1002/art.39750

    3. MR-detected features of inflammation and erosions occur in symptom-free persons from the general population

      L. Mangnus, H.W. van Steenbergen, M. Reijnierse and A.H.M. van der Helm-van Mil

      Accepted manuscript online: 23 MAY 2016 02:36PM EST | DOI: 10.1002/art.39749

  45. Review Articles

    1. You have full text access to this OnlineOpen article
      Hematopoietic Stem Cell Transplantation for Scleroderma: Effective Immunomodulatory Therapy for Patients with Pulmonary Involvement

      Keith M. Sullivan, Ankoor Shah, Stefanie Sarantopoulos and Daniel E. Furst

      Accepted manuscript online: 23 MAY 2016 02:36PM EST | DOI: 10.1002/art.39748

  46. Full Length

    1. Limb Bud and Heart Development Gene Transcription is Regulated by the Interplay of an Enhancer Risk Allele and DNA Methylation in Rheumatoid Arthritis

      Deepa Hammaker, John W. Whitaker, Keisuke Maeshima, David L. Boyle, Anna-Karin H. Ekwall, Wei Wang and Gary S. Firestein

      Accepted manuscript online: 9 MAY 2016 11:14AM EST | DOI: 10.1002/art.39746

  47. Review Articles

    1. Neutrophils as Invigorated Targets in Rheumatic Diseases

      Peter C. Grayson, Christine Schauer, Martin Herrmann and Mariana J. Kaplan

      Accepted manuscript online: 9 MAY 2016 11:14AM EST | DOI: 10.1002/art.39745

  48. Full Length

    1. BCL-2 as a Therapeutic Target in Human Tubulointerstitial Inflammation

      Kichul Ko, Jianing Wang, Stuart Perper, Yulei Jiang, Denisse Yanez, Natalya Kaverina, Junting Ai, Vladimir M. Liarski, Anthony Chang, Yahui Peng, Li Lan, Susan Westmoreland, Lisa Olson, Maryellen L. Giger, Li Chun Wang and Marcus R. Clark

      Accepted manuscript online: 9 MAY 2016 11:13AM EST | DOI: 10.1002/art.39744

    2. Autoantigens targeted in scleroderma patients with vascular disease are enriched in endothelial lineage cells

      Zsuzsanna H. McMahan, Tricia R. Cottrell, Fredrick M. Wigley, Brendan Antiochos, Elias T. Zambidis, Tea Soon Park, Marc K. Halushka, Laura Gutierrez-Alamillo, Raffaello Cimbro, Antony Rosen and Livia Casciola-Rosen

      Accepted manuscript online: 9 MAY 2016 11:13AM EST | DOI: 10.1002/art.39743

  49. Brief Reports

    1. Causes of stillbirths in women with systemic lupus erythematosus

      Évelyne Vinet, Geneviève Genest, Susan Scott, Christian A. Pineau, Ann E. Clarke, Robert W. Platt and Sasha Bernatsky

      Accepted manuscript online: 9 MAY 2016 11:13AM EST | DOI: 10.1002/art.39742

  50. Full Length

    1. Pin1-targeted therapy against systemic lupus erythematosus

      Shuo Wei, Nobuya Yoshida, Greg Finn, Shingo Kozono, Morris Nechama, Vasileios C. Kyttaris, Xiao Zhen Zhou, George C. Tsokos and Kun Ping Lu

      Accepted manuscript online: 9 MAY 2016 11:13AM EST | DOI: 10.1002/art.39741

  51. Brief Reports

    1. A Prospective Open Label Phase IIa Trial of Tocilizumab In the Treatment of Polymyalgia Rheumatica

      Lindsay Lally, Lindsy Forbess, Christopher Hatzis and Robert Spiera

      Accepted manuscript online: 9 MAY 2016 11:13AM EST | DOI: 10.1002/art.39740

  52. Full Length

    1. Fibroblast growth factor receptor 3 inhibits osteoarthritis progression in knee joints of adult mice

      Junzhou Tang, Nan Su, Siru Zhou, Yangli Xie, Junlan Huang, Xuan Wen, Zuqiang Wang, Quan Wang, Wei Xu, Xiaolan Du, Hangang Chen and Lin Chen

      Accepted manuscript online: 9 MAY 2016 11:13AM EST | DOI: 10.1002/art.39739

    2. Association between breast cancer recurrence with immunosuppression in rheumatoid arthritis and inflammatory bowel disease: A cohort study

      Ronac Mamtani, Amy S. Clark, Frank I. Scott, Colleen M. Brensinger, Ben Boursi, Lang Chen, Fenglong Xie, Huifeng Yun, Mark T Osterman, Jeffrey R. Curtis and James D. Lewis

      Accepted manuscript online: 9 MAY 2016 11:13AM EST | DOI: 10.1002/art.39738

    3. Early, incomplete, or preclinical autoimmune systemic rheumatic diseases and pregnancy outcome

      Arsenio Spinillo, Fausta Beneventi, Elena Locatelli, Vèronique Ramoni, Roberto Caporali, Claudia Alpini, Giulia Albonico, Chiara Cavagnoli and Carlomaurizio Montecucco

      Accepted manuscript online: 9 MAY 2016 11:13AM EST | DOI: 10.1002/art.39737

    4. A comparative analysis of the peptide repertoires of HLA-DR molecules differentially associated to rheumatoid arthritis

      Erika Scholz, Anna Mestre-Ferrer, Xavier Daura, Noel García-Medel, Montserrat Carrascal, Eddie A. James, William W. Kwok, Francesc Canals and Iñaki Alvarez

      Accepted manuscript online: 9 MAY 2016 11:12AM EST | DOI: 10.1002/art.39736

    5. Associations of circulating cytokines and chemokines with cancer mortality in men with rheumatoid arthritis

      Bryant R. England, Jeremy Sokolove, William H. Robinson, Geoffrey M. Thiele, Apar K. Ganti, Harlan Sayles, Kaleb Michaud, Liron Caplan, Lisa A. Davis, Grant W. Cannon, Brian Sauer, Namrata Singh, E. Blair Solow, Andreas M. Reimold, Gail S. Kerr, Pascale Schwab, Josh F. Baker and Ted R. Mikuls

      Accepted manuscript online: 25 APR 2016 09:50AM EST | DOI: 10.1002/art.39735

    6. Functional Interaction of the Ankylosing Spondylitis Associated Endoplasmic Reticulum Aminopeptidase 2 with the HLA-B*27 Peptidome in Human Cells

      Adrian Martín-Esteban, Pablo Guasp, Eilon Barnea, Arie Admon and José A. López de Castro

      Accepted manuscript online: 25 APR 2016 09:50AM EST | DOI: 10.1002/art.39734

    7. Prion-like MAVS aggregation in lupus patients associates with increased interferon-I

      Wen-Hai Shao, Daniel H. Shu, Yuxuan Zhen, Brendan Hilliard, Stephen O. Priest, Matteo Cesaroni, Jenny P-Y. Ting and Philip L. Cohen

      Accepted manuscript online: 25 APR 2016 09:50AM EST | DOI: 10.1002/art.39733

    8. IL-23-dependent γδ T cells produce IL-17 and accumulate in enthesis, aortic valve, and ciliary body

      Annika Reinhardt, Tetyana Yevsa, Tim Worbs, Stefan Lienenklaus, Inga Sandrock, Linda Oberdörfer, Thomas Korn, Siegfried Weiss, Reinhold Förster and Immo Prinz

      Accepted manuscript online: 25 APR 2016 09:50AM EST | DOI: 10.1002/art.39732

    9. Semi-Quantitative Imaging Biomarkers of Knee Osteoarthritis Progression: Data from the FNIH OA Biomarkers Consortium

      Jamie E. Collins, Elena Losina, Michael C. Nevitt, Frank W. Roemer, Ali Guermazi, John A. Lynch, Jeffrey N. Katz, C. Kent Kwoh, Virginia B. Kraus and David J. Hunter

      Accepted manuscript online: 25 APR 2016 09:50AM EST | DOI: 10.1002/art.39731

  53. Brief Reports

    1. Cross-disease Meta-analysis of Genome-wide Association Studies for Systemic Sclerosis and Rheumatoid Arthritis Reveals IRF4 as a New Common Susceptibility Locus

      Elena López-Isac, Jose-Ezequiel Martín, Shervin Assassi, Carmen P. Simeón, Patricia Carreira, Norberto Ortego-Centeno, Mayka Freire, Emma Beltrán, Javier Narváez, Juan J. Alegre-Sancho, the Spanish Scleroderma Group, Benjamín Fernández-Gutiérrez, Alejandro Balsa, Ana M. Ortiz, Miguel A. González-Gay, Lorenzo Beretta, Alessandro Santaniello, Chiara Bellocchi, Claudio Lunardi, Gianluca Moroncini, Armando Gabrielli, Torsten Witte, Nicolas Hunzelmann, Jörg H.W. Distler, Gabriella Riekemasten, Annete H. van der Helm-van Mil, Jeska de Vries-Bouwstra, Cesar Magro-Checa, Alexandre E. Voskuyl, Madelon C. Vonk, Øyvind Molberg, Tony Merriman, Roger Hesselstrand, Annika Nordin, Leonid Padyukov, Ariane Herrick, Steve Eyre, Bobby P.C. Koeleman, Christopher P. Denton, Carmen Fonseca, Timothy R.D.J. Radstake, Jane Worthington, Maureen D. Mayes and Javier Martín

      Accepted manuscript online: 25 APR 2016 09:50AM EST | DOI: 10.1002/art.39730

  54. Full Length

    1. Comparing presenting clinical features of 48 children with microscopic polyangiitis (MPA) against 183 having granulomatosis with polyangiitis (GPA). An ARChiVe study

      David A. Cabral, Debra L. Canter, Eyal Muscal, Kabita Nanda, Dawn M. Wahezi, Steven J. Spalding, Marinka Twilt, Susanne M. Benseler, Sarah Campillo, Sirirat Charuvanij, Paul Dancey, Barbara A. Eberhard, Melissa E. Elder, Aimee Hersh, Gloria Higgins, Adam M. Huber, Raju Khubchandani, Susan Kim, Marisa Klein-Gitelman, Mikhail Kostik, Erica Lawson, Tzielan Lee, Joanna M. Lubieniecka, Deborah McCurdy, Lakshmi N. Moorthy, Kimberly A. Morishita, Susan M. Nielsen, Kathleen M. O'Neil, Andreas Reiff, Goran Ristic, Angela B. Robinson, Angelyne Sarmiento, Susan Shenoi, Mary B. Toth, Heather Van Mater, Linda Wagner-Weiner, Jennifer E. Weiss, Andrew J. White, Rae S.M. Yeung and ARChiVe Investigators Network within the PedVas initiative

      Accepted manuscript online: 25 APR 2016 09:50AM EST | DOI: 10.1002/art.39729

    2. Induction of scleroderma fibrosis in skin-humanized mice by anti-Platelet-Derived Growth Factor receptor agonistic autoantibodies

      Michele M. Luchetti, Gianluca Moroncini, Maria Jose Escamez, Silvia Svegliati Baroni, Tatiana Spadoni, Antonella Grieco, Chiara Paolini, Ada Funaro, Enrico V. Avvedimento, Fernando Larcher, Marcela Del Rio and Armando Gabrielli

      Accepted manuscript online: 25 APR 2016 09:50AM EST | DOI: 10.1002/art.39728

  55. Editorial

    1. Are Autoantibodies Involved in the Pathogenesis of Systemic Sclerosis?

      Marvin J. Fritzler and May Y. Choi

      Accepted manuscript online: 25 APR 2016 09:49AM EST | DOI: 10.1002/art.39727

  56. Full Length

    1. Trabecular Bone Score in Patients with Chronic Glucocorticoid-Induced Osteoporosis Treated with Alendronate or Teriparatide

      Kenneth G Saag, Donato Agnusdei, Didier Hans, Lynn A Kohlmeier, Kelly D Krohn, Edward S Leib, Edmund J MacLaughlin, Jahangir Alam, Christine Simonelli, Kathleen A Taylor and Robert Marcus

      Accepted manuscript online: 25 APR 2016 09:49AM EST | DOI: 10.1002/art.39726

    2. MiR-130b ameliorates murine lupus nephritis through targeting type I interferon pathway on resident renal cells

      Xiao Han, Yan Wang, Xiaoyan Zhang, Yuting Qin, Bo Qu, Lingling Wu, Jianyang Ma, Zhenyuan Zhou, Jie Qian, Min Dai, Yuanjia Tang, Edward K. L. Chan, John B. Harley, Shiyu Zhou and Nan Shen

      Accepted manuscript online: 25 APR 2016 09:49AM EST | DOI: 10.1002/art.39725

    3. Association between serum antibodies to periodontal bacteria and rheumatoid factor in NHANES III

      Charlene E. Goh, Jacob Kopp, Panos N. Papapanou, Jerry A. Molitor and Ryan T. Demmer

      Accepted manuscript online: 25 APR 2016 09:49AM EST | DOI: 10.1002/art.39724

  57. Editorial

    1. The Ethics of Recent Gout Trials

      Robert H. Shmerling

      Accepted manuscript online: 25 APR 2016 09:49AM EST | DOI: 10.1002/art.39723

  58. Full Length

    1. You have full text access to this OnlineOpen article
      A multicenter, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of treatment with sirukumab (CNTO 136) in patients with active lupus nephritis

      Brad Rovin, Ronald van Vollenhoven, Cynthia Aranow, Carrie Wagner, Robert Gordon, Yanli Zhuang, Stanley Belkowski and Benjamin Hsu

      Accepted manuscript online: 25 APR 2016 09:49AM EST | DOI: 10.1002/art.39722

  59. Brief Reports

    1. Whole Exome Sequencing for Identification of Potential Causal Variants for Diffuse Cutaneous Systemic Sclerosis

      Angel CY Mak, Paul LF Tang, Clare Cleveland, Melanie H Smith, M Kari Connolly, Tamiko R Katsumoto, Paul J Wolters, Pui-Yan Kwok and Lindsey A Criswell

      Accepted manuscript online: 25 APR 2016 09:49AM EST | DOI: 10.1002/art.39721

  60. Full Length

    1. Epigenetic reprogramming in naïve CD4+ T cells favoring T cell activation and non-Th1 effector T cell immune response as an early event in lupus flares

      Patrick Coit, Mikhail G. Dozmorov, Joan T. Merrill, W. Joseph McCune, Kathleen Maksimowicz-McKinnon, Jonathan D. Wren and Amr H. Sawalha

      Accepted manuscript online: 25 APR 2016 09:48AM EST | DOI: 10.1002/art.39720

    2. You have full text access to this OnlineOpen article
      Nailfold Videocapillaroscopic and Other Clinical Risk Factors for Digital Ulcers in Systemic Sclerosis: A Multicenter, Prospective Cohort Study

      Maurizio Cutolo, Ariane L. Herrick, Oliver Distler, Mike Becker, Emma Beltran, Patrick Carpentier, Clodoveo Ferri, Murat Inanç, Panayiotis Vlachoyiannopoulos, Harbajan Chadha-Boreham, Emmanuelle Cottreel, Thomas Pfister, Daniel Rosenberg, Juan V. Torres, Vanessa Smith and on behalf of the videoCAPillaroscopy (CAP) study investigators.

      Accepted manuscript online: 25 APR 2016 09:48AM EST | DOI: 10.1002/art.39718

  61. Editorial

  62. Full Length

    1. Granulation tissue eroding the subchondral bone also promotes new bone formation in ankylosing spondylitis

      Janine Bleil, Rene Maier, Axel Hempfing, Joachim Sieper, Heiner Appel and Uta Syrbe

      Accepted manuscript online: 25 APR 2016 09:32AM EST | DOI: 10.1002/art.39715

  63. Brief Reports

    1. Estimating disease activity using multi-biomarker disease activity scores in patients with rheumatoid arthritis treated with abatacept or adalimumab

      Roy Fleischmann, Sean E Connolly, Michael A Maldonado and Michael Schiff

      Accepted manuscript online: 25 APR 2016 09:32AM EST | DOI: 10.1002/art.39714

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