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Annals of Clinical and Translational Neurology

Articles are published under the terms of the Creative Commons License as stated in the final article.

Cover image for Vol. 2 Issue 5

Editor-in-Chief: Jack Kessler, MD

Online ISSN: 2328-9503

Just Published Articles

  1. You have full text access to this OnlineOpen article
    Cerebrospinal fluid aquaporin-4-immunoglobulin G disrupts blood brain barrier

    Nasrin Asgari, Carsten Tue Berg, Marlene Thorsen Mørch, Reza Khorooshi and Trevor Owens

    Article first published online: 29 MAY 2015 | DOI: 10.1002/acn3.221

  2. You have full text access to this OnlineOpen article
    A systems-level “misunderstanding”: the plasma metabolome in Huntington's disease

    Herminia D. Rosas, Gheorghe Doros, Swati Bhasin, Beena Thomas, Sona Gevorkian, Keith Malarick, Wayne Matson and Steven M. Hersch

    Article first published online: 28 MAY 2015 | DOI: 10.1002/acn3.214

  3. You have full text access to this OnlineOpen article
    CSF neurofilament light chain reflects corticospinal tract degeneration in ALS

    Ricarda A. L. Menke, Elizabeth Gray, Ching-Hua Lu, Jens Kuhle, Kevin Talbot, Andrea Malaspina and Martin R. Turner

    Article first published online: 25 MAY 2015 | DOI: 10.1002/acn3.212

  4. You have full text access to this OnlineOpen article
    Rapidly progressive intracranial artery stenosis in primary antiphospholipid syndrome

    Christian L. Seifert, Markus C. Kowarik, Klaus Thürmel, Achim Berthele, Sascha Prothmann and Silke Wunderlich

    Article first published online: 25 MAY 2015 | DOI: 10.1002/acn3.215

  5. You have full text access to this OnlineOpen article
    Low neural exosomal levels of cellular survival factors in Alzheimer's disease

    Edward J. Goetzl, Adam Boxer, Janice B. Schwartz, Erin L. Abner, Ronald C. Petersen, Bruce L. Miller, Olga D. Carlson, Maja Mustapic and Dimitrios Kapogiannis

    Article first published online: 13 MAY 2015 | DOI: 10.1002/acn3.211


Meet the Editor

Meet the editor

John Kessler

John "Jack" Kessler, MD, has been appointed Editor-in-Chief of Annals of Clinical and Translational Neurology. Dr. Kessler is the Ken and Ruth Davee Professor of Stem Cell Biology at Northwestern University and previously was chair of Neurology at Northwestern University Feinberg School of Medicine. His laboratory investigates stem cell biology and approaches to regeneration of the damaged or diseased nervous system. Dr. Kessler’s research has focused extensively on the regulation of gene expression by neural stem/progenitor cells and their differentiated progeny. Read Dr. Kessler's inaugural editorial here.

The American Neurological Association

Journal Events

Save the Date

ANA's 140th Annual Meeting September 27-29, 2015 Chicago, IL
For more information click here.


The American Neurological Association (ANA) is a professional society of academic neurologists and neuroscientists devoted to understanding and treating diseases of the central nervous system. The ANA publishes the Annals of Neurology. It has a 2012 Impact Factor of 11.193 and is among the most prestigious peer-reviewed clinical neurology journals worldwide. The Annals of Neurology supports Annals of Clinical and Translational Neurology by referring selected papers to the journal.

Annals of Neurology

Journal News

Journal News

ACTN is now listed in the Directory of Open Access Journals (DOAJ), an online directory that indexes and provides access to quality open access, peer-reviewed journals.


NEW FINDING: Dual MRI technique leads to more accurate ALS diagnosis

The article, Multi-modal MRI as a Diagnostic Biomarker for Amyotrophic Lateral Sclerosis, explains how two different types of magnetic resonance imaging (MRI) on the brain can diagnose amyotrophic lateral sclerosis (ALS) more accurately than using a single type of MRI alone. This finding could aid in earlier diagnoses, and more effective treatment, of the deadly disease.

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Annals of Clinical and Translational Neurology is a peer-reviewed journal for rapid dissemination of high-quality research related to all areas of neurology. The journal publishes original research and scholarly reviews focused on the mechanisms and treatments of diseases of the nervous system; high-impact topics in neurologic education; and other topics of interest to the clinical neuroscience community.

Reasons to publish with ACTN:
• High standard, rigorous peer review
• Quality and reputation: supported by ANA’s Annals of Neurology
• Rapid publication
• Article-by-article publication – no delay in waiting for the issue to close
• Open access: freely available on Wiley Online Library
• Authors retain copyright and articles are published under a Creative Commons License
• Fully compliant with open access mandates: meeting the requirements of funding organizations and institutions where these apply.


Annals of Clinical and Translational Neurology is now included in PubMedCentral. All content that has been, and will be, published in the journal will be processed for indexing in PubMedCentral.

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