Biotechnology Progress

Copyright © 2013 American Institute of Chemical Engineers

Cover image for Vol. 29 Issue 2

Early View (Online Version of Record published before inclusion in an issue)

Edited By: Michael M. Domach

Impact Factor: 2.34

ISI Journal Citation Reports © Ranking: 2011: 25/128 (Food Science & Technology); 70/158 (Biotechnology & Applied Microbiology)

Online ISSN: 1520-6033

Associated Title(s): AIChE Journal, Environmental Progress & Sustainable Energy, Process Safety Progress

  1. Bioseparations and Downstream Processing

    1. Profiling the effects of process changes on residual host cell proteins in biotherapeutics by mass spectrometry

      Matthew R. Schenauer, Gregory C. Flynn and Andrew M. Goetze

      Article first published online: 21 MAY 2013 | DOI: 10.1002/btpr.1748

  2. Cell Culture and Tissue Engineering

    1. You have full text access to this OnlineOpen article
      Very high density of Chinese hamster ovary cells in perfusion by alternating tangential flow or tangential flow filtration in WAVE bioreactor™—part II: Applications for antibody production and cryopreservation

      Marie-Françoise Clincke, Carin Mölleryd, Puneeth K Samani, Eva Lindskog, Eric Fäldt, Kieron Walsh and Véronique Chotteau

      Article first published online: 21 MAY 2013 | DOI: 10.1002/btpr.1703

    2. You have full text access to this OnlineOpen article
      Very high density of CHO cells in perfusion by ATF or TFF in WAVE bioreactor™. Part I. Effect of the cell density on the process

      Marie-Françoise Clincke, Carin Mölleryd, Ye Zhang, Eva Lindskog, Kieron Walsh and Véronique Chotteau

      Article first published online: 21 MAY 2013 | DOI: 10.1002/btpr.1704

    3. Comparative analysis of reference gene stability in human mesenchymal stromal cells during osteogenic differentiation

      Angela Jacobi, Juliane Rauh, Peter Bernstein, Cornelia Liebers, Xuenong Zou and Maik Stiehler

      Article first published online: 15 MAY 2013 | DOI: 10.1002/btpr.1747

  3. Biocatalysts and Bioreactor Design

    1. Enzymatic digestion of alkaline-sulfite pretreated sugar cane bagasse and its correlation with the chemical and structural changes occurring during the pretreatment step

      Fernanda M. Mendes, Debora F. Laurito, Mariana Bazzeggio, André Ferraz and Adriane M. F. Milagres

      Article first published online: 11 MAY 2013 | DOI: 10.1002/btpr.1746

  4. Applied Cellular Physiology and Metabolic Engineering

    1. Manipulation of kynurenine pathway for enhanced daptomycin production in Streptomyces roseosporus

      Guojian Liao, Lei Wang, Qing Liu, Feifei Guan, Yuqi Huang and Changhu Hu

      Article first published online: 11 MAY 2013 | DOI: 10.1002/btpr.1740

  5. Process Sensing and Control

    1. The critical flux method for reduced filter membrane fouling when monitoring high-solids digesters

      Stephan Tait, Christopher R. Carney and Damien J. Batstone

      Article first published online: 11 MAY 2013 | DOI: 10.1002/btpr.1743

  6. Cell Culture and Tissue Engineering

    1. Improvement of mammalian cell culture performance through surfactant enabled concentrated feed media

      Patrick Hossler, Sean McDermott, Christopher Racicot and John C. H. Fann

      Article first published online: 11 MAY 2013 | DOI: 10.1002/btpr.1739

  7. Biocatalysts and Bioreactor Design

    1. Mass production of spores of lactic acid-producing Rhizopus oryzae NBRC 5384 on agar plate

      Tsuneo Yamane and Ryosuke Tanaka

      Article first published online: 9 MAY 2013 | DOI: 10.1002/btpr.1744

    2. Enhancing operational stability and exhibition of enzyme activity by removing water in the immobilized lipase-catalyzed production of erythorbyl laurate

      Da Eun Lee, Kyung Min Park, Seung Jun Choi, Jae-Hoon Shim and Pahn-Shick Chang

      Article first published online: 9 MAY 2013 | DOI: 10.1002/btpr.1745

  8. Cell Culture and Tissue Engineering

    1. Three-dimensional neural differentiation of embryonic stem cells with ACM induction in microfibrous matrices in bioreactors

      Ning Liu, Anli Ouyang, Yan Li and Shang-Tian Yang

      Article first published online: 9 MAY 2013 | DOI: 10.1002/btpr.1742

  9. Bioseparations and Downstream Processing

    1. Effect of glycosylation on the partition behavior of a human antibody in aqueous two-phase systems

      J.-W. Lee and D. Forciniti

      Article first published online: 9 MAY 2013 | DOI: 10.1002/btpr.1741

  10. Cell Culture and Tissue Engineering

    1. Computational fluid modeling and performance analysis of a bidirectional rotating perfusion culture system

      Chang-Wei Kang, Yan Wang, Marshella Tania, Huancheng Zhou, Yi Gao, Te Ba, Guo-Dong Sean Tan, Sangho Kim and Hwa Liang Leo

      Article first published online: 9 MAY 2013 | DOI: 10.1002/btpr.1736

    2. Interaction between abscisic acid and nitric oxide in PB90-induced catharanthine biosynthesis of catharanthus roseus cell suspension cultures

      Qian Chen, Zunwei Chen, Li Lu, Haihong Jin, Lina Sun, Qin Yu, Hongke Xu, Fengxia Yang, Mengna Fu, Shengchao Li, Huizhong Wang and Maojun Xu

      Article first published online: 2 MAY 2013 | DOI: 10.1002/btpr.1738

  11. Biocatalysts and Bioreactor Design

    1. Effect of enzyme dehydration on alcalase-catalyzed dipeptide synthesis in near-anhydrous organic media

      Petra Vossenberg, Rik Beeftink, Martien Cohen Stuart and Hans Tramper

      Article first published online: 2 MAY 2013 | DOI: 10.1002/btpr.1737

  12. Bioseparations and Downstream Processing

    1. Experimental and theoretical investigation of multistage extraction of 1,3-propanediol using the extraction system phosphate/1-butyl-3-methylimidazolium trifluoromethanesulfonate/water

      Anja Müller, Philip Lutze and Andrzej Górak

      Article first published online: 2 MAY 2013 | DOI: 10.1002/btpr.1735

  13. Cell Culture and Tissue Engineering

    1. Use of the mitochondria toxicity assay for quantifying the viable cell density of microencapsulated jurkat cells

      M. Werner, K. Biss, V. Jérôme, F. Hilbrig, R. Freitag, K. Zambrano, H. Hübner, R. Buchholz, R. Mahou and C. Wandrey

      Article first published online: 2 MAY 2013 | DOI: 10.1002/btpr.1734

  14. Bioseparations and Downstream Processing

    1. You have full text access to this OnlineOpen article
      Differential response in downstream processing of CHO cells grown under mild hypothermic conditions

      Andrew S. Tait, Richard D. R. Tarrant, M. Lourdes Velez-Suberbie, Daniel I. R. Spencer and Daniel G. Bracewell

      Article first published online: 2 MAY 2013 | DOI: 10.1002/btpr.1726

  15. Applied Cellular Physiology and Metabolic Engineering

    1. Strictosidine-related enzymes involved in the alkaloid biosynthesis of Uncaria tomentosa root cultures grown under oxidative stress

      Ileana Vera-Reyes, Ariana A. Huerta-Heredia, Teresa Ponce-Noyola, Isvett Josefina Flores-Sanchez, Fernando Esparza-García, Carlos M. Cerda-García-Rojas, Gabriela Trejo-Tapia and Ana C. Ramos-Valdivia

      Article first published online: 22 APR 2013 | DOI: 10.1002/btpr.1723

  16. Bioseparations and Downstream Processing

    1. Purification and biochemical characterization of feruloyl esterases from Aspergillus terreus MTCC 11096

      C. Ganesh Kumar, Avijeet Kamle and Ahmed Kamal

      Article first published online: 22 APR 2013 | DOI: 10.1002/btpr.1729

  17. Cell Culture and Tissue Engineering

    1. Fermentanomics informed amino acid supplementation of an antibody producing mammalian cell culture

      Erik K. Read, Scott A. Bradley, Tim A. Smitka, Cyrus D. Agarabi, Scott C. Lute and Kurt A. Brorson

      Article first published online: 22 APR 2013 | DOI: 10.1002/btpr.1728

  18. Process Sensing and Control

    1. Feed rate control in fed-batch fermentations based on frequency content analysis

      Ola Johnsson, Jonas Andersson, Gunnar Lidén, Charlotta Johnsson and Tore Hägglund

      Article first published online: 22 APR 2013 | DOI: 10.1002/btpr.1727

  19. Applied Cellular Physiology and Metabolic Engineering

    1. Metabolic engineering of Clostridium acetobutylicum for the enhanced production of isopropanol-butanol-ethanol fuel mixture

      Yu-Sin Jang, Alok Malaviya, Joungmin Lee, Jung Ae Im, Sang Yup Lee, Julia Lee, Moon-Ho Eom, Jung-Hee Cho and Do Young Seung

      Article first published online: 18 APR 2013 | DOI: 10.1002/btpr.1733

  20. Biocatalysts and Bioreactor Design

    1. Chitinolytic enzymes: An appraisal as a product of commercial potential

      S. B. Chavan and M. V. Deshpande

      Article first published online: 18 APR 2013 | DOI: 10.1002/btpr.1732

  21. Cell Culture and Tissue Engineering

    1. Cell-based screening of traditional chinese medicines for proliferation enhancers of mouse embryonic stem cells

      Ding Li, Sarah Isherwood, Andrew Motz, Ru Zang, Shang-Tian Yang, Jufang Wang and Xiaoning Wang

      Article first published online: 18 APR 2013 | DOI: 10.1002/btpr.1731

    2. Chinese hamster ovary K1 host cell enables stable cell line development for antibody molecules which are difficult to express in DUXB11-derived dihydrofolate reductase deficient host cell

      Zhilan Hu, Donglin Guo, Shirley S.M. Yip, Dejin Zhan, Shahram Misaghi, John C. Joly, Bradley R. Snedecor and Amy Y. Shen

      Article first published online: 18 APR 2013 | DOI: 10.1002/btpr.1730

  22. Bioseparations and Downstream Processing

    1. Separation, antitumor activities, and encapsulation of polypeptide from Chlorella pyrenoidosa

      Xiaoqin Wang and Xuewu Zhang

      Article first published online: 18 APR 2013 | DOI: 10.1002/btpr.1725

  23. Formulation and Engineering of Biomaterials

    1. Hemorheological implications of perfluorocarbon based oxygen carrier interaction with colloid plasma expanders and blood

      Diana M. Vásquez, Daniel Ortiz, Oscar A. Alvarez, Juan C. Briceño and Pedro Cabrales

      Article first published online: 18 APR 2013 | DOI: 10.1002/btpr.1724

  24. Cell Culture and Tissue Engineering

    1. Case Study: An accelerated 8-day monoclonal antibody production process based on high seeding densities

      Ishai Padawer, Wai Lam W. Ling and Yunling Bai

      Article first published online: 18 APR 2013 | DOI: 10.1002/btpr.1719

  25. Bioseparations and Downstream Processing

    1. Multipronged approach to managing beta-glucan contaminants in the downstream process: Control of raw materials and filtration with charge-modified nylon 6,6 membrane filters

      Eva Gefroh, Art Hewig, Ganesh Vedantham, Megan McClure, Alla Krivosheyeva, Ajay Lajmi and Yuefeng Lu

      Article first published online: 18 APR 2013 | DOI: 10.1002/btpr.1718

  26. Cell Culture and Tissue Engineering

    1. Use of perfluorocarbons to enhance the performance of perfused three-dimensional hepatic cultures

      Gengbei Shi and Robin N. Coger

      Article first published online: 18 APR 2013 | DOI: 10.1002/btpr.1716

  27. Formulation and Engineering of Biomaterials

    1. Polyethylene glycol-based low generation dendrimers functionalized with β-cyclodextrin as cryo- and dehydro-protectant of catalase formulations

      Patricio R. Santagapita, M. Florencia Mazzobre, Ariel García Cruz, Horacio R. Corti, Reynaldo Villalonga and M. Pilar Buera

      Article first published online: 18 APR 2013 | DOI: 10.1002/btpr.1713

    2. Loofa (Luffa cylindrica) sponge: Review of development of the biomatrix as a tool for biotechnological applications

      Asma Saeed and Muhammad Iqbal

      Article first published online: 18 APR 2013 | DOI: 10.1002/btpr.1702

  28. Cell Culture and Tissue Engineering

    1. Resilient immortals, characterizing and utilizing Bax/Bak deficient Chinese hamster ovary (CHO) cells for high titer antibody production

      Shahram Misaghi, Yan Qu, Andrew Snowden, Jennifer Chang and Brad Snedecor

      Article first published online: 18 APR 2013 | DOI: 10.1002/btpr.1722

  29. Biocatalysts and Bioreactor Design

    1. Production of humic acids from oil palm empty fruit bunch by submerged fermentation with Trichoderma viride: Cellulosic substrates and nitrogen sources

      F L. Motta and M. H. A. Santana

      Article first published online: 8 APR 2013 | DOI: 10.1002/btpr.1715

    2. Microplates as a microreactor platform for microalgae research

      Adriana Pacheco, Ileana Hernández-Mireles, Cecilia García-Martínez and Mario M. Álvarez

      Article first published online: 8 APR 2013 | DOI: 10.1002/btpr.1721

  30. Formulation and Engineering of Biomaterials

    1. Improving of red colorants production by a new Penicillium purpurogenum strain in submerged culture and the effect of different parameters in their stability

      Valéria Carvalho Santos-Ebinuma, Inês Conceição Roberto, Maria Francisca Simas Teixeira and Adalberto Pessoa Jr

      Article first published online: 1 APR 2013 | DOI: 10.1002/btpr.1720

  31. Bioseparations and Downstream Processing

    1. Separation of nonfucosylated antibodies with immobilized FcγRIII receptors

      Glen R. Bolton, Margaret E. Ackerman and Austin W. Boesch

      Article first published online: 1 APR 2013 | DOI: 10.1002/btpr.1717

  32. Process Sensing and Control

    1. Multispectral image analysis for algal biomass quantification

      Thomas E. Murphy, Keith Macon and Halil Berberoglu

      Article first published online: 1 APR 2013 | DOI: 10.1002/btpr.1714

  33. Applied Cellular Physiology and Metabolic Engineering

    1. Rapid removal of glycerol from frozen-thawed red blood cells

      Ratih E. Lusianti, James D. Benson, Jason P. Acker and Adam Z. Higgins

      Article first published online: 29 MAR 2013 | DOI: 10.1002/btpr.1710

  34. Bioseparations and Downstream Processing

    1. Quantification of protein mixture in chromatographic separation using multi-wavelength UV spectra

      Mark-Henry Kamga, Hae Woo Lee, Jay Liu and Seongkyu Yoon

      Article first published online: 29 MAR 2013 | DOI: 10.1002/btpr.1712

    2. Aqueous biphasic systems composed of ionic liquids and sodium carbonate as enhanced routes for the extraction of tetracycline

      Carlos F. C. Marques, Teresa Mourão, Catarina M. S. S. Neves, Álvaro S. Lima, Isabel Boal-Palheiros, João A. P. Coutinho and Mara G. Freire

      Article first published online: 29 MAR 2013 | DOI: 10.1002/btpr.1708

    3. Intermolecular interactions during ultrafiltration of pegylated proteins

      Krisada Ruanjaikaen and Andrew L. Zydney

      Article first published online: 29 MAR 2013 | DOI: 10.1002/btpr.1709

  35. Cell Culture and Tissue Engineering

    1. Glassy State and Cryopreservation of Mint Shoot Tips

      Aline S. Teixeira, M. Elena González-Benito and Antonio D. Molina-García

      Article first published online: 27 MAR 2013 | DOI: 10.1002/btpr.1711

  36. Applied Cellular Physiology and Metabolic Engineering

    1. Cell-free protein synthesis and purification of human dopamine D2 receptor long isoform

      Dipannita Basu, Jessica M. Castellano, Nancy Thomas and Ram K. Mishra

      Article first published online: 27 MAR 2013 | DOI: 10.1002/btpr.1706

  37. Cell Culture and Tissue Engineering

    1. A CHO cell line engineered to express XBP1 and ERO1-Lα has increased levels of transient protein expression

      Katharine Cain, Shirley Peters, Hanna Hailu, Bernie Sweeney, Paul Stephens, James Heads, Kaushik Sarkar, Andy Ventom, Catherine Page and Alan Dickson

      Article first published online: 20 MAR 2013 | DOI: 10.1002/btpr.1693

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