BJU International

Cover image for Vol. 119 Issue 3

Edited By: Prokar Dasgupta

Impact Factor: 4.387

ISI Journal Citation Reports © Ranking: 2015: 10/77 (Urology & Nephrology)

Online ISSN: 1464-410X

Virtual Issues

List of BJUI Virtual Issues

Best of Australia and New Zealand 2017

BJU USANZ Cover 2017

BJUI present The Best of Australia and New Zealand 2017. A free collection of the best articles from those countries published in the BJUI over the past year.

68Ga-PSMA has a high detection rate of prostate cancer recurrence outside the prostatic fossa in patients being considered for salvage radiation treatment
Pim J. van Leeuwen, Phillip Stricker, George Hruby, Andrew Kneebone, Francis Ting, Ben Thompson, Quoc Nguyen, Bao Ho and Louise Emmett

Guideline of guidelines: follow-up after nephrectomy for renal cell carcinoma
Timothy J. Williamson, John R. Pearson, Joseph Ischia, Damien M. Bolton and Nathan Lawrentschuk

Patterns-of-care and health economic analysis of robot-assisted radical prostatectomy in the Australian public health system
Marnique Basto, Niranjan Sathianathen, Luc te Marvelde, Shane Ryan, Jeremy Goad, Nathan Lawrentschuk, Anthony J. Costello, Daniel A. Moon, Alexander G. Heriot, Jim Butler and Declan G. Murphy

Aquablation – image-guided robot-assisted waterjet ablation of the prostate: initial clinical experience
Peter Gilling, Rana Reuther, Arman Kahokehr and Mark Fraundorfer

The use of portable video media vs standard verbal communication in the urological consent process: a multicentre, randomised controlled, crossover trial
Matthew Winter, Jonathan Kam, Sunny Nalavenkata, Ellen Hardy, Marcus Handmer, Hannah Ainsworth, Wai Gin Lee and Mark Louie-Johnsun

Urology technical and non-technical skills development: the emerging role of simulation
Prem Rashid and Troy R.J. Gianduzzo

Conjoint Urological Society of Australia and New Zealand (USANZ) and Urogynaecological Society of Australasia (UGSA) Guidelines on the management of adult non-neurogenic overactive bladder
Vincent Tse, Jennifer King, Caroline Dowling, Sharon English, Katherine Gray, Richard Millard, Helen O'Connell, Samantha Pillay and Jeffrey Thavaseelan

Best of India 2017


To celebrate the Golden Jubilee of USICON taking place this month in Mumbai, BJUI presents the best papers from India of 2016 beginning with a blog by Amit Ghose on the last days of the great Kabiguru Rabindranath Tagore.


Tagore’s Last Days: the little Prostate ends a big Legend

The three best Indian papers of 2016

Comparative testing of reliability and audit utility of ordinal objective calculus complexity scores. Can we make an informed choice yet?
Jiten Jaipuria, Manav Suryavanshi and Tridib K. Sen

Role of oral pentosan polysulphate in the reduction of local side effects of BCG therapy in patients with non-muscle-invasive bladder cancer: a pilot study
Suresh Yadav, Vinay Tomar, Sher Singh Yadav, Shivam Priyadarshi and Indraneel Banerjee

Factors predicting outcomes of micropercutaneous nephrolithotomy: results from a large single-centre experience
Arvind Ganpule, Jaspreet Singh Chhabra, Vinayak Kore, Shashikant Mishra, Ravindra Sabnis and Mahesh Desai

The three best International papers with significant Indian contribution

Preoperative JJ stent placement in ureteric and renal stone treatment: results from the Clinical Research Office of Endourological Society (CROES) ureteroscopy (URS)
Global Study Dean Assimos, Alfonso Crisci, Daniel Culkin, Wei Xue, Anita Roelofs, Mordechai Duvdevani, Mahesh Desai, Jean de la Rosette and on behalf of the CROES URS Global Study Group

Super-mini percutaneous nephrolithotomy (SMP): a new concept in technique and instrumentation
Guohua Zeng, ShawPong Wan, Zhijian Zhao, Jianguo Zhu, Aierken Tuerxun, Chao Song, Liang Zhong, Ming Liu, Kewei Xu, Hulin Li, Zhiqiang Jiang, Sanjay Khadgi, Shashi K. Pal, Jianjun Liu, Guoxi Zhang, Yongda Liu, Wenqi Wu, Wenzhong Chen and Kemal Sarica

Robot-assisted partial nephrectomy in cystic tumours: analysis of the Vattikuti Global Quality Initiative in Robotic Urologic Surgery (GQI-RUS) database
Giacomo Novara, Sabrina La Falce, Ronney Abaza, James Adshead, Rajesh Ahlawat, Nicolò Maria Buffi, Ben Challacombe, Prokar Dasgupta, Daniel A. Moon, Dipen J. Parekh, Francesco Porpiglia, Sudhir Rawal, Craig Rogers, Alessandro Volpe, Mahendra Bhandari and Alexander Mottrie

Best of China 2016

BJU Best of China 16

In recent years, an increase in the quantity and quality of research from urologists in China had led to a corresponding rise in the number of articles being published in prestigious journals like BJUI. We are pleased to present this virtual issue of some of the last best papers from China published in the BJUI over the last two years. The virtual issue included six studies from Chinese urologists covering the translational science, clinical research, and high-quality systematic review. Innovation is the soul of scientific and technological development. Zeng and colleagues introduced a novel miniature endoscopic system, named the “super-mini-percutaneous nephrolithotomy” (SMP), which appeared to be a safe and efficient procedure for moderate size kidney stones. Xu and colleagues explained the mechanism of enhancer of zeste homolog 2 (EZH2) in renal cell carcinoma (RCC) progress, and believed EZH2 might be a potential therapeutic target for advanced RCC. Two of these six articles relate to prostate disease. Li and colleagues reported their ten years of experience in the transperineal template-guided prostate biopsy. Wang and colleagues provided the evidence to show prostatic arterial embolization is a safe and effective treatment for patients with lower urinary tract symptoms caused by benign prostatic hyperplasia. Urethral stricture is a common and recurring condition in contemporary urological practice. To understand the current causes and treatment of urethral strictures in China, Xu and colleagues conducted a multi-center observational survey of male urethral strictures in China between 2005 and 2010. Pelvic floor reconstruction with mesh has become the main surgical procedure for the treatment of pelvic organ prolapse and stress urinary incontinence. In the meta-analysis by Deng et al., we can learn the risk factors for mesh erosion after female pelvic floor reconstruction with synthetic meshes, which is helpful for us for selecting better surgical procedures. We hope that you enjoy reading these articles and that you find this collection useful and stimulating.

Prof. Guohua Zeng,
The First Affiliated Hospital of Guangzhou Medical University


Enhancer of zeste homolog 2 (EZH2) promotes tumour cell migration and invasion via epigenetic repression of E-cadherin in renal cell carcinoma
Li Liu, Zhibing Xu, Lei Zhong, Hang Wang, Shuai Jiang, Qilai Long, Jiejie Xu and Jianming Guo

Prostatic arterial embolization for the treatment of lower urinary tract symptoms caused by benign prostatic hyperplasia: a comparative study of medium- and large-volume prostates
Maoqiang Wang, Liping Guo, Feng Duan, Kai Yuan, Guodong Zhang, Kai Li, Jieyu Yan, Yan Wang and Haiyan Kang

Risk factors for mesh erosion after female pelvic floor reconstructive surgery: a systematic review and meta-analysis
Tuo Deng, Banghua Liao, Deyi Luo, Hong Shen and Kunjie Wang

Changing trends in the causes and management of male urethral stricture disease in China: an observational descriptive study from 13 centres
Yue-Min Xu, Lu-Jie Song, Kun-Jie Wang, Jian Lin, Guang Sun, Zhong-Jin Yue, Hai Jiang, Yu-Xi Shan, Shao-Xing Zhu, Yu-Jie Wang, Zhi-Ming Liu, Zhen-Hua Li, Zhong-Hua Liu, Qing-Ke Chen and Min-Kai Xie

Transperineal template-guided prostate biopsy: 10 years of experience
Zhipeng Mai, Weigang Yan, Yi Zhou, Zhien Zhou, Jian Chen, Yu Xiao, Zhiyong Liang, Zhigang Ji and Hanzhong Li

Super-mini percutaneous nephrolithotomy (SMP): a new concept in technique and instrumentation
Guohua Zeng, ShawPong Wan, Zhijian Zhao, Jianguo Zhu, Aierken Tuerxun, Chao Song, Liang Zhong, Ming Liu, Kewei Xu, Hulin Li, Zhiqiang Jiang, Sanjay Khadgi, Shashi K. Pal, Jianjun Liu, Guoxi Zhang, Yongda Liu, Wenqi Wu, Wenzhong Chen and Kemal Sarica

Best of Korea


Robot-assisted Fallopian tube transection and anastomosis using the new REVO-I robotic surgical system: feasibility in a chronic porcine model
Ali Abdel Raheem, Irela Soto Troya, Dae Keun Kim, Se hoon Kim, Park Dong Won, Park Sung Joon, Gim Soo Hyun and Koon Ho Rha

Low testosterone level is an independent risk factor for high-grade prostate cancer detection at biopsy
Juhyun Park, Sung Yong Cho, Seung-hwan Jeong, Seung Bae Lee, Hwancheol Son and Hyeon Jeong

Testosterone modulates endothelial progenitor cells in rat corpus cavernosum
Insang Hwang, Hyun-Suk Lee, Ho Song Yu, Mi Eun Kim, Jun Sik Lee and Kwangsung Park

De Ritis ratio (aspartate transaminase/alanine transaminase ratio) as a significant prognostic factor after surgical treatment in patients with clear-cell localized renal cell carcinoma: a propensity score-matched study
Hakmin Lee, Sang Eun Lee, Seok-Soo Byun, Hyeon Hoe Kim, Cheol Kwak and Sung Kyu Hong

Comparison of the efficacy and safety of tolterodine 2 mg and 4 mg combined with an α-blocker in men with lower urinary tract symptoms (LUTS) and overactive bladder: a randomized controlled trial
Tae Heon Kim, Wonho Jung, Yoon Seok Suh, Soonhyun Yook, Hyun Hwan Sung and Kyu-Sung Lee

Virtual Issue: The Best of Asia 2016

UAA VI 2016
As the 14th Urological Association of Asia Congress gets underway in Singapore this week, BJUI presents a free Virtual Issue of some of the best recently published papers from UAA’s member countries.

Safety and efficacy of mirabegron as ‘add-on’ therapy in patients with overactive bladder treated with solifenacin: a post-marketing, open-label study in Japan (MILAI study)
Osamu Yamaguchi, Hidehiro Kakizaki, Yukio Homma, Yasuhiko Igawa, Masayuki Takeda, Osamu Nishizawa, Momokazu Gotoh, Masaki Yoshida, Osamu Yokoyama, Narihito Seki, Akira Okitsu, Takuya Hamada, Akiko Kobayashi and Kentarou Kuroishi

Stratification of patients with intermediate-risk prostate cancer
Jin-Woo Jung, Jung Keun Lee, Sung Kyu Hong, Seok-Soo Byun and Sang Eun Lee

Transurethral intraprostatic injection of botulinum neurotoxin type A for the treatment of chronic prostatitis/chronic pelvic pain syndrome: results of a prospective pilot double-blind and randomized placebo-controlled study
Siavash Falahatkar, Elaheh Shahab, Keivan Gholamjani Moghaddam and Ehsan Kazemnezhad

Significance of the interval between first and second transurethral resection on recurrence and progression rates in patients with high-risk non-muscle-invasive bladder cancer treated with maintenance intravesical Bacillus Calmette-Guérin
Sümer Baltacı, Murat Bozlu, Asıf Yıldırım, Mehmet İlker Gökçe, İlker Tinay, Güven Aslan, Cavit Can, Levent Türkeri, Uğur Kuyumcuoğlu and Aydın Mungan

Propensity-score matched analysis comparing robot-assisted with laparoscopic partial nephrectomy
Zhenjie Wu, Mingmin Li, Shangqing Song, Huamao Ye, Qing Yang, Bing Liu, Chen Cai, Bo Yang, Liang Xiao, Qi Chen, Chen Lü, Xu Gao, Chuanliang Xu, Xiaofeng Gao, Jianguo Hou, Linhui Wang and Yinghao Sun

Comparative effectiveness and safety of various treatment procedures for lower pole renal calculi: a systematic review and network meta-analysis
Shaun Wen-Huey Lee, Nathorn Chaiyakunapruk, Huey-Yi Chong and Men-Long Liong

Transrectal ultrasonography (TRUS)-guided pelvic plexus block to reduce pain during prostate biopsy: a randomised controlled trial
Tarun Jindal, Subhabrata Mukherjee, Rajan K. Sinha, Mir R. Kamal, Nabankur Ghosh, Barun Saha, Nilanjan Mitra, Pramod K. Sharma, Soumendra N. Mandal and Dilip Karmakar

The #BAUS16 Virtual Issue

BAUS 2016
We hope you will enjoy the BJUI Editor-in-Chief’s selection of the best of recent British papers published as a BJUI Virtual Issue to coincide with BAUS 2016. This year’s articles include clinical research, basic science and reviews and cover a wide range of urological topics.

Determination of optimal drug dose and light dose index to achieve minimally invasive focal ablation of localised prostate cancer using WST11-vascular-targeted photodynamic (VTP) therapy
Caroline M. Moore, Abel-Rahmene Azzouzi, Eric Barret, Arnauld Villers, Gordon H. Muir, Neil J. Barber, Simon Bott, John Trachtenberg, Nimalan Arumainayagam, Bertrand Gaillac, Clare Allen, Avigdor Schertz and Mark Emberton

The emerging use of Twitter by urological journals
Gregory J. Nason, Fardod O'Kelly, Michael E. Kelly, Nigel Phelan, Rustom P. Manecksha, Nathan Lawrentschuk and Declan G. Murphy

Am I normal? A systematic review and construction of nomograms for flaccid and erect penis length and circumference in up to 15 521 men
David Veale, Sarah Miles, Sally Bramley, Gordon Muir and John Hodsoll

Diagnosis and treatment of chronic bacterial prostatitis and chronic prostatitis/chronic pelvic pain syndrome: a consensus guideline
Jon Rees, Mark Abrahams, Andrew Doble, Alison Cooper and for the Prostatitis Expert Reference Group (PERG)

Is there an antiandrogen withdrawal syndrome with enzalutamide?
Alejo Rodriguez-Vida, Diletta Bianchini, Mieke Van Hemelrijck, Simon Hughes, Zafar Malik, Thomas Powles, Amit Bahl, Sarah Rudman, Heather Payne, Johann de Bono and Simon Chowdhury

International multicentre psychometric evaluation of patient-reported outcome data for the treatment of Peyronie's disease
Verena Kueronya, Arkadius Miernik, Slavisa Stupar, Vladimir Kojovic, Georgios Hatzichristodoulou, Paulo H. Egydio, Georgi Tosev, Marco Falcone, Francesco De Luca, Demir Mulalic, Miroslav Djordjevic, Martin Schoenthaler, Christian Fahr and Franklin E. Kuehhas

Development of a standardised training curriculum for robotic surgery: a consensus statement from an international multidisciplinary group of experts
Kamran Ahmed, Reenam Khan, Alexandre Mottrie, Catherine Lovegrove, Ronny Abaza, Rajesh Ahlawat, Thomas Ahlering, Goran Ahlgren, Walter Artibani, Eric Barret, Xavier Cathelineau, Ben Challacombe, Patrick Coloby, Muhammad S. Khan, Jacques Hubert, Maurice Stephan Michel, Francesco Montorsi, Declan Murphy, Joan Palou, Vipul Patel, Pierre-Thierry Piechaud, Hendrik Van Poppel, Pascal Rischmann, Rafael Sanchez-Salas, Stefan Siemer, Michael Stoeckle, Jens-Uwe Stolzenburg, Jean-Etienne Terrier, Joachim W. Thüroff, Christophe Vaessen, Henk G. Van Der Poel, Ben Van Cleynenbreugel, Alessandro Volpe, Christian Wagner, Peter Wiklund, Timothy Wilson, Manfred Wirth, Jörn Witt and Prokar Dasgupta

Burden of male lower urinary tract symptoms (LUTS) suggestive of benign prostatic hyperplasia (BPH) – focus on the UK
Mark Speakman, Roger Kirby, Scott Doyle and Chris Ioannou

Simulation-based training for prostate surgery
Raheej Khan, Abdullatif Aydin, Muhammad Shamim Khan, Prokar Dasgupta and Kamran Ahmed

Diagnostic accuracy of magnetic resonance imaging (MRI) prostate imaging reporting and data system (PI-RADS) scoring in a transperineal prostate biopsy setting
Alistair D.R. Grey, Manik S. Chana, Rick Popert, Konrad Wolfe, Sidath H. Liyanage and Peter L. Acher

ATP release from freshly isolated guinea-pig bladder urothelial cells: a quantification and study of the mechanisms involved
Linda M. McLatchie and Christopher H. Fry

Virtual Issue: Articles of the Month 2015


Every issue the BJUI Editor-in-Chief, Prokar Dasgupta, selects a paper he thinks is the most important, interesting or clinically useful as the Article of the Month. Here we collect all of the 2015 Articles of the Month into one Virtual Issue making them free to all our readers.

Progression and treatment of incident lower urinary tract symptoms (LUTS) among men in the California Men's Health Study
Lauren P. Wallner, Jeff M. Slezak, Ronald K. Loo, Virginia P. Quinn, Stephen K. Van Den Eeden and Steven J. Jacobsen

Indications for intervention during active surveillance of prostate cancer: a comparison of the Johns Hopkins and Prostate Cancer Research International Active Surveillance (PRIAS) protocols
Max Kates, Jeffrey J. Tosoian, Bruce J. Trock, Zhaoyong Feng, H. Ballentine Carter and Alan W. Partin

Is there an antiandrogen withdrawal syndrome with enzalutamide?
Alejo Rodriguez-Vida, Diletta Bianchini, Mieke Van Hemelrijck, Simon Hughes, Zafar Malik, Thomas Powles, Amit Bahl, Sarah Rudman, Heather Payne, Johann de Bono and Simon Chowdhury

Clinical performance of the Prostate Health Index (PHI) for the prediction of prostate cancer in obese men: data from the PROMEtheuS project, a multicentre European prospective study
Alberto Abrate, Massimo Lazzeri, Giovanni Lughezzani, Nicolòmaria Buffi, Vittorio Bini, Alexander Haese, Alexandre de la Taille, Thomas McNicholas, Joan Palou Redorta, Giulio M. Gadda, Giuliana Lista, Ella Kinzikeeva, Nicola Fossati, Alessandro Larcher, Paolo Dell'Oglio, Francesco Mistretta, Massimo Freschi and Giorgio Guazzoni

Transient receptor potential channel modulators as pharmacological treatments for lower urinary tract symptoms (LUTS): myth or reality?
Yves Deruyver, Thomas Voets, Dirk De Ridder and Wouter Everaerts

Clinical utility of 18F-fluorocholine positron-emission tomography/computed tomography (PET/CT) in biochemical relapse of prostate cancer after radical treatment: results of a multicentre study
Sonia Rodado-Marina, Mónica Coronado-Poggio, Ana María García-Vicente, Jose Ramón García-Garzón, Juan Carlos Alonso-Farto, Aurora Crespo de la Jara, Antonio Maldonado-Suárez and Antonio Rodríguez-Fernández

Targeted microbubbles: a novel application for the treatment of kidney stones
Krishna Ramaswamy, Vanessa Marx, Daniel Laser, Thomas Kenny, Thomas Chi, Michael Bailey, Mathew D. Sorensen, Robert H. Grubbs and Marshall L. Stoller

Perineal repair of pelvic fracture urethral injury: in pursuit of a successful outcome
Mamdouh M. Koraitim and Mohamed I. Kamel

Patient-reported ‘ever had’ and ‘current’ long-term physical symptoms after prostate cancer treatments
Anna T. Gavin, Frances J. Drummond, Conan Donnelly, Eamonn O'Leary, Linda Sharp and Heather R. Kinnear

Safety and efficacy of mirabegron as ‘add-on’ therapy in patients with overactive bladder treated with solifenacin: a post-marketing, open-label study in Japan (MILAI study)
Osamu Yamaguchi, Hidehiro Kakizaki, Yukio Homma, Yasuhiko Igawa, Masayuki Takeda, Osamu Nishizawa, Momokazu Gotoh, Masaki Yoshida, Osamu Yokoyama, Narihito Seki, Akira Okitsu, Takuya Hamada, Akiko Kobayashi and Kentarou Kuroishi

Final quality of life and safety data for patients with metastatic castration-resistant prostate cancer treated with cabazitaxel in the UK Early Access Programme (EAP) (NCT01254279)
Amit Bahl, Susan Masson, Zafar Malik, Alison J. Birtle, Santhanam Sundar, Rob J. Jones, Nicholas D. James, Malcolm D. Mason, Satish Kumar, David Bottomley, Anna Lydon, Simon Chowdhury, James Wylie and Johann S. de Bono

Virtual Issue: Guideline of Guidelines

GOG VI 2015

I requested our Associate Editor Stacy Loeb, who has a strong background in statistical methodology and health services research, to launch a series entitled ‘Guideline of Guidelines’ (GOGs). Most busy urologists tell me that they often find the many different society guidelines confusing. So we decided to publish a critical summary, finishing up with a set of ‘key points’ that our readers can use in their day-to-day practices. And what better way to kick off than with our biggest controversy – screening for prostate cancer. Here we present all of our GoGs published to date in a free online collection.

Prokar Dasgupta, Editor-in-Chief

Guideline of guidelines: prostate cancer screening
Stacy Loeb

Guideline of guidelines: kidney stones
Justin B. Ziemba and Brian R. Matlaga

Guideline of Guidelines: Imaging of Localized Prostate Cancer
Daniel A. Wollin and Danil V. Makarov

Guideline of guidelines: urinary incontinence
Raveen Syan and Benjamin M. Brucker

Guideline of guidelines: a review of urological trauma guidelines
Darren J. Bryk and Lee C. Zhao

Urological recommendations from the National Institute for Health and Care Excellence (NICE) Guideline, June 2015: Suspected cancer: recognition and referral
Edward R. Jefferies, Simon F. Brewster and on behalf of the BAUS Section on Oncology

Guideline of Guidelines: follow-up after nephrectomy for renal cell carcinoma
Timothy J Williamson, John R Pearson, Joseph Ischia, Damien M Bolton and Nathan Lawrentschuk

New devices and old concepts describe the current treatment choices in BPH.


The world of minimally-invasive treatments for managing symptomatic Benign Prostatic Hyperplasia (BPH) continues to evolve with several new players emerging and further consolidation occurring on the part of established techniques. This Virtual Issue contains a selection of articles and reviews that have appeared in the BJUI over the past year and these offerings provide a fair representation of the techniques and issues discussed at the major meetings in 2015.

Articles on new and relatively controversial techniques are included. Not only is the mechanism of action uncertain for these techniques but the way they are being utilised in the treatment paradigm is interesting. Porpiglia and colleagues use a novel prostatic stent in symptomatic men with small prostates but remove it after only 5 days and achieve a surprisingly durable result. The prostatic urethral ‘lift’ is examined by Cantwell and colleagues. These authors follow the fortunes of patients in the sham arm of the L.I.F.T. study who had the device placed 3-6 months later per protocol [1]. In the short term the patients appear to do well. Wang and colleagues treated 115 patients with Prostatic Artery Embolisation and compared patients with larger (>80 mL) and smaller glands. Unsurprisingly the larger prostates had larger arteries and longer hospital stays but appeared to get a better clinical result at 12 months. Similarly Somani et al report good results with PAE and provide an overview of the situation in the UK with this modality.

The validation and documentation of a new and improved way of training surgeons who wish to undertake 532nm laser vaporisation is presented by Aydin and colleagues. Several of these authors’ were also involved in providing a similar model for HoLEP training, both of which appear to represent valid and useful tools for the future [2].

Vaporisation of the prostate using different 532nm devices (120 and 180Watts) is further reviewed. The cost compared to TURP was equivalent in the study by Whitty and colleagues. As expected, less perioperative morbidity was noted in the laser group which was offset by greater expense. In a review of the data with the 180 Watt laser by Brunken et al a further reduction in operative times compared with older devices was noted but early-adopter bias may account for most of this. Finally, a comparison of HoLEP with Vaporisation using different 532nm devices in patients in chronic urinary retention was presented by Jaeger and colleagues. Although both procedures were of value in this group the proportion that became catheter free appeared to be greater in the HoLEP group (99%) compared to those in the vaporisation group (74%) as would be expected. This difficult patient population remind us that there remain many BPH patients who will not be well served by techniques that fail to adequately dis-obstruct patients. However, there does appear to be renewed interest in these devices which compete more with medication than traditional TURP. A tailored approach is becoming increasingly necessary.

Peter Gilling, BJUI Consulting Editor, Tauranga, New Zealand

1. Roehrborn CG, Rukstalis DB, Barkin J, Gange SN, Shore ND, Giddens JL, et al. Three year results of the prostatic urethral L.I.F.T. study. Can J Urol. 2015;22(3):7772-82. Epub 2015/06/13.
2. Kuronen-Stewart C, Ahmed K, Aydin A, Cynk M, Miller P, Challacombe B, et al. Holmium Laser Enucleation of the Prostate: Simulation Based Training Curriculum and Validation. Urology. 2015. Epub 2015/07/02.

Temporary implantable nitinol device

1.Temporary implantable nitinol device (TIND): a novel, minimally invasive treatment for relief of lower urinary tract symptoms (LUTS) related to benign prostatic hyperplasia (BPH): feasibility, safety and functional results at 1 year of follow-up
Francesco Porpiglia, Cristian Fiori, Riccardo Bertolo, Diletta Garrou, Giovanni Cattaneo and Daniele Amparore

Prostatic Urethral lift

2. Multicentre prospective crossover study of the ‘prostatic urethral lift’ for the treatment of lower urinary tract symptoms secondary to benign prostatic hyperplasia
Anthony L. Cantwell, William K. Bogache, Steven F. Richardson, Ronald F. Tutrone, Jack Barkin, James E. Fagelson6, Peter T. Chin7 and Henry H. Woo8

Prostate Artery Embolization

3. Prostate artery embolization pae for benign prostatic hyperplasia (BPH)
Bhaskar K. Somani, Nigel Hacking, Timothy Bryant, John Coyne, David Flowers, Mark Harris and Jonathan Dyer

4. Prostatic arterial embolization for the treatment of lower urinary tract symptoms caused by benign prostatic hyperplasia: a comparative study of medium- and large-volume prostates
Maoqiang Wang Maoqiang Wang, Liping Guo, Feng Duan, Kai Yuan, Guodong Zhang, Kai Li, Jieyu Yan, Yan Wang and Haiyan Kang

Photoselective vaporisation

5. Validation of the GreenLight™ Simulator and development of a training curriculum for photoselective vaporisation of the prostate
Abdullatif Aydin, Gordon H. Muir, Manuela E. Graziano, Muhammad Shamim Khan, Prokar Dasgupta And Kamran Ahmed

6. A cost-minimisation analysis comparing photoselective vaporisation (PVP) and transurethral resection of the prostate (TURP) for the management of symptomatic benign prostatic hyperplasia (BPH) in Queensland, Australia
Jennifer A. Whitty, Paul Crosland , Kaye Hewson, Rajan Narula, Timothy R. Nathan, Peter A. Campbell, Andrew Keller and Paul A. Scuffham

7. A systematic review of experience of 180-W XPS GreenLight laser vaporisation of the prostate in 1640 men
Claus Brunken, Christian Seitz and Henry H. Woo

8. Holmium laser enucleation (HoLEP) and photoselective vaporisation of the prostate (PVP) for patients with benign prostatic hyperplasia (BPH) and chronic urinary
Christopher D. Jaeger, Christopher R. Mitchell, Lance A. Mynderse And Amy E. Krambeck

Virtual Issue: Paediatrics

This online Virtual Issue includes some of the important paediatrics publications from BJUI over last two years.

In the realm of paediatric minimally invasive surgery (MIS), robotic application is slowly increasing to complex procedures with safe and critical selection, as described in the review article by Orvieto et al, leading to the next step to reduce surgical morbidity. Authors from Los Angeles have compared different approaches (Open/Robotic and LESS) to nephrectomy and it seems to have the benefits of reduced analgesia and hospitalization, compared to an open approach. The robotic approach requires more time compared to others and probably a steeper learning curve with available instrumentation (Kim et al). The population based study in the USA for pyeloplasty has not shown this widespread adoption of MIS, perhaps due to the study period being 2004-2008. The use of robotic technology became more common after 2008, and the other reason could be that a laparoscopic pyeloplasty has a long learning curve (Knoedler et al).
Hypospadias remains a challenging topic for geneticists and paediatric urologists, as it is difficult to pinpoint the cause, association and how can it be prevented (Iris et al).
The passion to improve the functional outcomes by understanding the anatomy in bladder exstrophy remains a quest, as described by Anusionwu et al, because the long-term sexual satisfaction is suboptimal for males as reported in the present study by Gupta et al. The reconstructions were performed 20 years ago in these patients, and the surgical principles have evolved over these years, and hopefully we will see better outcomes in the next 20 years.
There is a mammoth task to undertake: to streamline and have a structured follow-up for data collection, with respect to urological outcomes in closed spinal dysrahisim and neurogenic bladder patients, as supported by the article by Veenboer et al. Establishing adolescent urology units with a dedicated team may be an answer to this problem (Wood et al).
Pediatric stone management – PNL has shown comparable outcomes and complications with adults as reported by CROES study (Guven et al). ESWL has still to show long-term safety in regards to development of HT, DM and renal growth (El Nahas et al).

Mohan S Gundeti MD MCh FEBU FRCS (Urol) FEAPU
BJUI Consulting Editor, Associate Professor

Early comparison of nephrectomy options in children (open, transperitoneal laparoscopic, laparo-endoscopic single site (LESS), and robotic surgery)
Kim, Ph; Patil, Mb; Kim, Ss; Dorey, F; De Filippo, Re; Chang, Ay; Hardy, Be; Gill, Is; Desai, Mm; Koh, Cj

Robotic paediatric urology
Orvieto, Ma; Large, M; Gundeti, Ms

Risk factors for different phenotypes of hypospadias: results from a Dutch case–control study
Iris A.L.M. van Rooij, Loes F.M. van der Zand en, Marijn M. Brouwers, Nine V.A.M. Knoers, Wout F.J. Feitz and Nel Roeleveld

Comparison of musculoskeletal anatomic relationships, determined by magnetic resonance imaging, in postpubertal female patients with and without classic bladder exstrophy
Ifeanyi Anusionwu, Aylin Tekes, Andrew A. Stec, John P. Gearhart and E. James Wright

Nomogram and scoring system for predicting stone-free status after extracorporeal shock wave lithotripsy in children with urolithiasis
Onal, B; Tansu, N; Demirkesen, O; Yalcin, V; Huang, L; Nguyen, HT; Cilento, BG; Erozenci, A

Percutaneous nephrolithotomy in children in different age groups: data from the Clinical Research Office of the Endourological Society (CROES) Percutaneous Nephrolithotomy Global Study
Guven, S; Frattini, A; Onal, B; Desai, M; Montanari, E; Kums, J; Garofalo, M; de la Rosette, J

Paucity of evidence for urinary tract outcomes in closed spinal dysraphism: a systematic review
Paul W. Veenboer, J.L.H. Ruud Bosch, Floris W.A. van Asbeck and Laetitia M.O. de Kort

Population-based comparison of laparoscopic and open pyeloplasty in paediatric pelvi-ureretic junction obstruction
Knoedler, J; Han, L; Granberg, C; Kramer, S; Chow, G; Gettman, M; Kimball, B; Moriarty, J; Kim, S; Husmann, D

Are there long-term effects of extracorporeal shockwave lithotripsy in paediatric patients?
El-Nahas, AR; Awad, BA; El-Assmy, AM; Abou El-Ghar, ME; Eraky, I; El-Kenawy, MR; Sheir, KZ

Examining long-term outcomes of bladder exstrophy: a 20-year follow-up
Angela D. Gupta, Sameer K. Goel, Christopher R.J. Woodhouse and Dan Wood

Joint Virtual Issue: BJUI and JSM - Best Papers in Sexual Medicine

BJU InternationalJournal of Sexual Medicine

We have the greatest pleasure in presenting this virtual issue of some of the best papers on Sexual Medicine in the BJUI and JSM. The articles are a selection of the highest quality basic, translational and the clinical research in this exciting and evolving field. They encompass both male and female sexual disorders.
This issue showcases a unique collaboration between two journals, bringing together some of our best papers in one place for your reading pleasure. Even better, it is free to all our global readers. Please enjoy them and send us your feedback.

Irwin Goldstein
Ian Eardley
Prokar Dasgupta

Male circumcision wound healing in human immunodeficiency virus (HIV)-negative and HIV- positive men in Rakai, Uganda
Godfrey Kigozi, Richard Musoke, Nehemiah Kighoma, Stephen Watya, David Serwadda, Fred Nalugoda, Noah Kiwanuka, James Nkale, Fred Wabwire-Mangen, Frederick Makumbi, Nelson K. Sewankambo, Ronald H. Gray and Maria J. Wawer
BJU International. Volume 113, Issue 1, January 2014, Pages: 127–132

Valproic acid prevents penile fibrosis and erectile dysfunction in cavernous nerve-injured rats.
Hannan JL, Kutlu O, Stopak BL, Liu X, Castiglione F, Hedlund P, Burnett AL, and Bivalacqua TJ.
J Sex Med 2014;11:1442–1451.

Effects of 12 weeks of tadalafil treatment on ejaculatory and orgasmic dysfunction and sexual satisfaction in patients with mild to severe erectile dysfunction: integrated analysis of 17 placebo-controlled studies
Darius A. Paduch, Alexander Bolyakov, Paula K. Polzer and Steven D. Watts
BJU International. Volume 111, Issue 2, February 2013, Pages: 334–343

Sildenafil promotes eNOS activation and inhibits NADPH oxidase in the transgenic sickle cell mouse penis.
Musicki B, Bivalacqua TJ, Champion HC, and Burnett AL.
J Sex Med 2014;11:424–430.

Penile Doppler sonographic and clinical characteristics in Peyronie's disease and/or erectile dysfunction: an analysis of 1500 men with male sexual dysfunction
Eric Chung, Hanmu Yan, Ling De Young and Gerald B. Brock
BJU International. Volume 110, Issue 8, October 2012, Pages: 1201–1205

Current opinions on alternative reservoir placement for inflatable penile prosthesis among members of the Sexual Medicine Society of North America.
Karpman E, Sadeghi-Nejad H, Henry G, Khera M, and Morey AF.
J Sex Med 2013;10:2115–2120.

Sexual function with localized prostate cancer: active surveillance vs radical therapy
Roderick C.N. van den Bergh, Ida J. Korfage, Monique J. Roobol, Chris H. Bangma, Harry J. de Koning, Ewout W. Steyerberg and Marie-Louise Essink-Bot
BJU International. Volume 110, Issue 7, October 2012, Pages: 1032–1039

Testosterone improves antidepressant-emergent loss of libido in women: Findings from a randomized, doubleblind, placebo-controlled trial.
Fooladi E, Bell RJ, Jane F, Robinson PJ, Kulkarni J, and Davis SR.
J Sex Med 2014;11:831–839.

Outcomes of clomiphene citrate treatment in young hypogonadal men
Darren J. Katz, Omar Nabulsi, Raanan Tal and John P. Mulhall
BJU International. Volume 110, Issue 4, August 2012, Pages: 573–578

Inhibition of phosphodiesterase 4 enhances clitoral and vaginal blood flow responses to dorsal clitoral nerve stimulation or PGE1 in anesthetized female rats.
Castiglione F, Bergamini A, Russo A, La Croce G, Castagna G, Colciago G, Salonia A, Rigatti P, Montorsi F, and Hedlund P.
J Sex Med 2013;10:939–950.

Virtual Issue: Diabetes, Obesity & Metabolic SyndromeVirtual Issue: Diabetes, Obesity & Metabolic Syndrome

BJUI presents a FREE Virtual Issue bringing together the best recent papers on Diabetes, Obesity and Metabolic Syndrome in Urology, selected by our Editor-in-Chief, Prokar Dasgupta

Introduction: Dr Jonathan Rees, GP, Backwell & Nailsea Medical Group with interest in Men’s Health & Urology

May 2014

The concept of ‘men’s health’ was for many years taken to consist of the male-specific urological conditions such as prostate disease and erectile dysfunction. However, despite the importance of these conditions, particularly in terms of quality of life, it is cardiovascular disease and the components of the metabolic syndrome (hypertension, type 2 diabetes, dyslipidaemia) which have the biggest impact on the shorter life expectancy (and healthy life expectancy) seen in men. This collection of articles reflects the increased interest and awareness of these issues amongst Urologists, and demonstrates a number of important themes that have been seen in the wider urological literature over recent years:

1. Obesity and other components of the metabolic syndrome are seen to significantly increase the risk of developing a number of urological conditions. Insulin resistance, the driving force behind many components of metabolic syndrome also appears to be implicated in the pathogenesis of erectile dysfunction, benign prostatic hyperplasia, prostate cancer, hypogonadism, nephrolithiasis and overactive bladder.

2. The presence of visceral obesity and the metabolic syndrome may influence biological outcomes in many conditions with, for instance, men with high waist circumference (a fundamental component of metabolic syndrome) seen to have more severe lower urinary tract symptoms, whilst those with prostate cancer shown to have more aggressive disease at diagnosis and worse outcomes after radical prostatectomy.

3. Central obesity in particular, and high body mass index in general, increases surgical complexity (with consequent risks to patient safety) and operating times, and is therefore an important factor in predicting surgical outcomes. As understanding of these associations grows within the specialty of Urology, it allows Urologists to act as true advocates for overall men’s health. Just as we have become familiar with looking for undiagnosed diabetes and future cardiovascular risk in men with erectile dysfunction, the evidence increasingly points to the importance of consideration of these issues in many other urological disease processes. Identification of central obesity, hypertension, dyslipidaemia, diabetes or ‘pre-diabetes’ and other components of the metabolic syndrome offers the potential for lifestyle intervention and primary prevention strategies. Urologists may wish to arrange these tests themselves or more likely, liaise with colleagues in primary care with more expertise in the management of these conditions.

Central obesity as measured by waist circumference is predictive of severity of lower urinary tract symptoms
Lee, Richard K.; Chung, Doreen; Chughtai, Bilal; Te, Alexis E.; Kaplan, Steven A.

Obesity is associated with castration-resistant disease and metastasis in men treated with androgen deprivation therapy after radical prostatectomy: results from the SEARCH database
Keto, Christopher J.; Aronson, William J.; Terris, Martha K.; Presti, Joseph C.; Kane, Christopher J.; Amling, Christopher L.; Freedland, Stephen J.

Association between obesity and alteration of sperm DNA integrity and mitochondrial activity
Fariello, Roberta M.; Pariz, Juliana R.; Spaine, Deborah M.; Cedenho, Agnaldo P.; Bertolla, Ricardo P.; Fraietta, Renato

Visceral obesity is a strong predictor of perioperative outcome in patients undergoing laparoscopic radical nephrectomy
Hagiwara, Masayuki; Miyajima, Akira; Hasegawa, Masanori; Jinzaki, Masahiro; Kikuchi, Eiji; Nakagawa, Ken; Oya, Mototsugu

Amelioration of diabetes-induced cavernosal fibrosis by antioxidant and anti-transforming growth factor-beta 1 therapies in inducible nitric oxide synthase-deficient mice
Ferrini, Monica G.; Moon, Joanne; Rivera, Steve; Rajfer, Jacob; Gonzalez-Cadavid, Nestor F.

Safety and efficacy of ureteroscopic lithotripsy for stone disease in obese patients: a systematic review of the literature
Aboumarzouk, Omar M.; Somani, Bhaskar; Monga, Manoj

Obesity is associated with worse oncological outcomes in patients treated with radical cystectomy
Chromecki, Thomas F.; Cha, Eugene K.; Fajkovic, Harun; Rink, Michael; Ehdaie, Behfar; Svatek, Robert S.; Karakiewicz, Pierre I.; Lotan, Yair; Tilki, Derya; Bastian, Patrick J.; Daneshmand, Siamak; Kassouf, Wassim; Durand, Matthieu; Novara, Giacomo; Fritsche, Hans-Martin; Burger, Maximilian; Izawa, Jonathan I.; Brisuda, Antonin; Babjuk, Marek; Pummer, Karl; Shariat, Shahrokh F

Metabolic syndrome increases the risk of aggressive prostate cancer detection
Morote, Juan; Ropero, Jordi; Planas, Jacques; Bastaros, Juan M.; Delgado, Gueisy; Placer, Jose; Celma, Anna; de Torres, Ines M.; Carles, Joan; Reventos, Jaume; Doll, Andreas

Special ASM IssueSpecial ASM Issue: The USANZ Collection

Welcome to this special on-line only edition of the BJUI USANZ Supplement! It is a collection of carefully selected past papers, which I hope members will enjoy reading.

It is the last edition of the Supplement with Prof David Nicol as Editor. Associate Professor Nathan Lawrentschuk takes over as the new Supplement Editor from the next issue and I have no doubt, Nathan will take up the challenge of continuing the great work by David Nicol. David has left a lasting legacy as inaugural editor and members will no doubt join with me enthusiastically in recognising his outstanding contribution to USANZ research and academia.

Nathan has the drive and enthusiasm to ensure the Journal’s quality and depth of publications are maintained. Could I sound a friendly warning that members, and especially SAG leaders will be gently coaxed by Nathan to produce papers for publication. This important period of USANZ history cannot be underestimated in its quest for justified recognition on the very crowded world stage of urology. Australian and New Zealand urologists have for too long been hiding their talents under a bushel. Please support Nathan as vigorously as you can and wish him well as he continues to display his many talents.

The Journal will continue to be available in hardcopy, on-line and via the USANZ website. In time, the paper version will be phased out as members adjust to the world communicating solely electronically!

I personally congratulate those members who have already stepped up to the plate by conducting research and writing papers that have been published. Enjoy your success and please encourage others to emulate your dedication and hard work. May USANZ’ torch shine brightly.

Steve Ruthven, President

Virtual Supplement

Non-steroidal anti-inflammatory drugs for lower urinary tract symptoms in benign prostatic hyperplasia: systematic review and meta-analysis of randomized controlled trials
Arman Kahokehr, Ryash Vather, Anthony Nixon and Andrew G. Hill

Intravesical chemotherapy plus bacille Calmette-Guérin in non-muscle invasive bladder cancer: a systematic review with meta-analysis
Baerin B. Houghton, Venu Chalasani, Dickon Hayne, Peter Grimison, Christopher S. B. Brown, Manish I. Patel, Ian D. Davis and Martin R. Stockler

Factors associated with treatment received by men diagnosed with prostate cancer in Queensland, Australia
Peter D. Baade, Danny R. Youlden, Robert A. Gardiner, Megan Ferguson, Joanne F. Aitken, John Yaxley and Suzanne K. Chambers

A systematic review of stereotactic radiotherapy ablation for primary renal cell carcinoma
Shankar Siva, Daniel Pham, Suki Gill, Niall M. Corcoran and Farshad Foroudi

High grade prostatic intraepithelial neoplasia does not display loss of heterozygosity at the mutation locus in BRCA2 mutation carriers with aggressive prostate cancer
Amber Willems-Jones, Liam Kavanagh, David Clouston, Damien Bolton, kConFab Investigators, Stephen Fox and Heather Thorne

The Prostate Cancer Registry: monitoring patterns and quality of care for men diagnosed with prostate cancer
Sue M. Evans, Jeremy L. Millar, Julie M. Wood, Ian D. Davis, Damien Bolton, Graham G. Giles, Mark Frydenberg, Albert Frauman, Antony Costello and John J. McNeil

A novel technique to limit renal warm ischaemia time during laparoscopic partial nephrectomy
Nikhil Sapre, Niall M. Corcoran, Anthony J. Costello and Dinesh Agarwal

Positive surgical margins are a risk factor for significant biochemical recurrence only in intermediate-risk disease
Niall M. Corcoran, Chris M. Hovens, Charles Metcalfe, Matthew K.H. Hong, John Pedersen, Rowan G. Casey, Justin Peters, Laurence Harewood, S. Larry Goldenberg, Anthony J. Costello and Martin E. Gleave

Conversion rates of abstracts presented at the Urological Society of Australia and New Zealand (USANZ) Annual Scientific Meeting into full-text journal articles
Peter D. Yoon, Venu Chalasani and Henry H. Woo

Greenlight hps™ 120-w laser vaporization vs transurethral resection of the prostate (60 ml): a 2-year randomized double-blind prospective urodynamic investigation

Henry H. Woo and James L. Symons

Trends in the use of of nephron-sparing surgery (NSS) at an Australian tertiary referral centre: an analysis of surgical decision-making using the R.E.N.A.L. nephrometry scoring system
Prassannah Satasivam, Nieroshan Rajarubendra, Ping Han Chia, Aasheen Munshey, Shomik Sengupta and Damien Bolton