Journal of Neurochemistry

Cover image for Vol. 131 Issue 3

Edited By: Jörg Schulz

Impact Factor: 4.244

ISI Journal Citation Reports © Ranking: 2013: 63/251 (Neurosciences); 74/291 (Biochemistry & Molecular Biology)

Online ISSN: 1471-4159

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Recently Published Articles

  1. Nuclear diacylglycerol lipase-α in rat brain cortical neurons: evidence of 2-arachidonoylglycerol production in concert with phospholipase C-β activity

    Gontzal García del Caño, Xabier Aretxabala, Imanol González-Burguera, Mario Montaña, Maider López de Jesús, Sergio Barrondo, Ramón J. Barrio, Carmen Sampedro, M. Arantzazu Goicolea and Joan Sallés

    Article first published online: 31 OCT 2014 | DOI: 10.1111/jnc.12963

    Thumbnail image of graphical abstract

    We report that phosphatidylinositol-phospholipase C (PtdIns-PLC) and diacylglycerol lipase (DAGL) activities are co-compartmentalized in isolated adult cortical neuronal nuclei, leading to a nuclear-localized production of the endocannabinoid 2-AG. Our results provide biochemical grounds to hypothesize a role for 2-AG locally produced within the neuronal nucleus. 2-AG, 2-arachidonoylglycerol; AA, arachidonic acid; ABHD6, α-β-hydrolase domain-6; COX-2, cyclooxygenase-2; DAGK, diacylglycerol kinase; DAGs, diacylglycerols; LPP, lipid phosphate phosphatase; MAGL, monoacylglycerol lipase; NAM, N-arachidonoylmaleimide; PA, phosphatidic acid; PGG2-G, prostaglandin G2-glycerol; PLD, phospholipase D; PtdCho, phosphatidylcholine; PtdInsP2, phosphatidylinositol-4,5-bisphosphate; THL, tetrahydrolipstatin.

  2. Ceftriaxone modulates uptake activity of glial glutamate transporter-1 against global brain ischemia in rats

    Yu-Yan Hu, Jing Xu, Min Zhang, Dan Wang, Li Li and Wen-Bin Li

    Article first published online: 31 OCT 2014 | DOI: 10.1111/jnc.12958

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    Glutamate uptake by glial glutamate transporter-1 (GLT-1) is the principal way to regulate extracellular glutamate homeostasis in central nervous system. Over-accumulation of glutamate results in excitotoxicity and injures neurons after cerebral ischemia. Ceftriaxone up-regulates GLT-1 expression and uptake of glutamate, diminishes the excitotoxicity of glutamate and then protects neurons against global brain ischemia.

  3. P301L tau expression affects glutamate release and clearance in the hippocampal trisynaptic pathway

    Holly C. Hunsberger, Carolyn C. Rudy, Seth R. Batten, Greg A. Gerhardt and Miranda N. Reed

    Article first published online: 31 OCT 2014 | DOI: 10.1111/jnc.12967

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    Pre-synaptic vesicular glutamate transporters (vGLUTs) package glutamate into vesicles before exocytosis into the synaptic cleft. Once in the extracellular space, glutamate acts on glutamate receptors. Glutamate is removed from the extracellular space by excitatory amino acid transporters, including GLT-1, predominantly localized to glia. P301L tau expression increases vGLUT expression and glutamate release, while also decreasing GLT-1 expression and glutamate clearance.

  4. Involvement of TG-interacting factor in microglial activation during experimental traumatic brain injury

    Chung-Ching Chio, Ching-Ping Chang, Mao-Tsun Lin, Fang-Cheng Su, Chung-Zhing Yang, Hong-Yu Tseng, Zi-Miao Liu and Huei-Sheng Huang

    Article first published online: 31 OCT 2014 | DOI: 10.1111/jnc.12971

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    This study investigated the roles of transforming growth-interacting factor (TGIF) in a traumatic brain injury (TBI)-rat model. We demonstrated the increase of TGIF levels in the activated microglia of the pericontusional cortex of rats with TBI. Intracerebral knockdown of TGIF in the pericontusional cortex of the TBI rats significantly attenuated micoglial activation, reduced the volume of damaged brain tissue, and facilitated recovery of limb motor function. We suggest that inhibition of TGIF might provide a promising therapeutic strategy for TBI.

  5. Loss of mitofusin 2 (Mfn2) links beta-amyloid-mediated mitochondrial fragmentation and Cdk5-induced oxidative stress in neuron cells

    Junghyung Park, Hoonsung Choi, Ju-Sik Min, Bokyung Kim, Sang-Rae Lee, Jong Won Yun, Myung-Sook Choi, Kyu-Tae Chang and Dong-Seok Lee

    Accepted manuscript online: 30 OCT 2014 11:26PM EST | DOI: 10.1111/jnc.12984