Journal of Neurochemistry

Cover image for Vol. 134 Issue 5

Edited By: Jörg Schulz

Impact Factor: 4.281

ISI Journal Citation Reports © Ranking: 2014: 55/252 (Neurosciences); 72/289 (Biochemistry & Molecular Biology)

Online ISSN: 1471-4159

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Recently Published Articles

  1. Down-regulation of BDNF in cell and animal models increases striatal-enriched protein tyrosine phosphatase 61 (STEP61) levels

    Jian Xu, Pradeep Kurup, Garikoitz Azkona, Tyler D. Baguley, Ana Saavedra, Angus C. Nairn, Jonathan A. Ellman, Esther Pérez-Navarro and Paul J. Lombroso

    Accepted manuscript online: 28 AUG 2015 07:26AM EST | DOI: 10.1111/jnc.13295

  2. Nicotinic acetylcholine receptors mediate donepezil-induced oligodendrocyte differentiation

    Osamu Imamura, Masaaki Arai, Minori Dateki, Ogata Toru, Ryuji Uchida, Hiroshi Tomoda and Kunio Takishima

    Accepted manuscript online: 28 AUG 2015 07:06AM EST | DOI: 10.1111/jnc.13294

  3. Distinct Binding of Amyloid Imaging Ligands to Unique Amyloid-β Deposited in the Presubiculum of Alzheimer's Disease

    Bin Ji, Chun-Jen Chen, Kazunori Bando, Hiroki Ashino, Hideaki Shiraishi, Hiroaki Sano, Hiroyuki Kasahara, Takao Minamizawa, Kazutaka Yamada, Maiko Ono, Ming-Rong Zhang, Chie Seki, Lars Farde, Tetsuya Suhara and Makoto Higuchi

    Accepted manuscript online: 28 AUG 2015 07:05AM EST | DOI: 10.1111/jnc.13293

  4. Treatment with human immunoglobulin G improves the early disease course in a mouse model of Duchenne muscular dystrophy

    Jana Zschüntzsch, Yaxin Zhang, Florian Klinker, Gregor Makosch, Lars Klinge, Dörthe Malzahn, Heinrich Brinkmeier, David Liebetanz and Jens Schmidt

    Article first published online: 28 AUG 2015 | DOI: 10.1111/jnc.13269

    Thumbnail image of graphical abstract

    Two monthly intraperitoneal injections of human immunoglobulin G (IgG) improved the early 11-week disease phase of mdx mice. Voluntary running was improved and serum levels of creatine kinase were diminished. In the skeletal muscle, myopathic damage was ameliorated and key inflammatory markers such as mRNA expression of SPP1 and infiltration by macrophages were reduced. The study suggests that IgG could be explored as a potential treatment option for Duchenne muscular dystrophy and that pre-clinical long-term studies should be helpful.

  5. Molecular cloning, epigenetic regulation, and functional characterization of Prkd1 gene promoter in dopaminergic cell culture models of Parkinson's disease

    Muhammet Ay, Huajun Jin, Dilshan S. Harischandra, Arunkumar Asaithambi, Arthi Kanthasamy, Vellareddy Anantharam and Anumantha G. Kanthasamy

    Article first published online: 28 AUG 2015 | DOI: 10.1111/jnc.13261

    Thumbnail image of graphical abstract

    Previously, we demonstrated that protein kinase D1 (PKD1) plays a survival role during the early stage of oxidative stress in dopaminergic neuronal cells. Here, we cloned and characterized the mouse Prkd1 gene promoter. Our results suggest that Sp1, Sp3, and NF-κB-p65 transactivate the mouse Prkd1 promoter and that histone acetylation and DNA methylation play important roles in regulating Prkd1 expression in neuronal cells.

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