Journal of Neurochemistry

Cover image for Vol. 133 Issue 5

Edited By: Jörg Schulz

Impact Factor: 4.244

ISI Journal Citation Reports © Ranking: 2013: 63/252 (Neurosciences); 74/291 (Biochemistry & Molecular Biology)

Online ISSN: 1471-4159

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Recently Published Articles

  1. Synaptic vesicle exocytosis and increased cytosolic calcium are both necessary but not sufficient for activity-dependent bulk endocytosis

    Andrew Morton, Jamie R.K. Marland and Michael A. Cousin

    Accepted manuscript online: 25 APR 2015 06:17AM EST | DOI: 10.1111/jnc.13132

  2. NCK is critical for the development of Deleted in Colorectal Cancer (DCC) sensitive spinal circuits

    Ciaran Lane, Jiansong Qi  and James P. Fawcett

    Accepted manuscript online: 25 APR 2015 02:29AM EST | DOI: 10.1111/jnc.13137

  3. Novel splice variants in the 5’UTR of Gtf2i expressed in the rat brain: alternative 5’UTRs and differential expression in the neuronal dendrites

    Yoshinori Shirai, Masahiko Watanabe, Hiroyuki Sakagami and Tatsuo Suzuki

    Accepted manuscript online: 25 APR 2015 02:00AM EST | DOI: 10.1111/jnc.13136

  4. Macrophages treated with particulate matter PM2.5 induce selective neurotoxicity through glutaminase-mediated glutamate generation

    Fang Liu, Yunlong Huang, Fang Zhang, Qiang Chen, Beiqing Wu, Wei Rui, Jialin C. Zheng and Wenjun Ding

    Accepted manuscript online: 25 APR 2015 01:42AM EST | DOI: 10.1111/jnc.13135

  5. 1–42 oligomer-induced leakage in an in vitro blood–brain barrier model is associated with up-regulation of RAGE and metalloproteinases, and down-regulation of tight junction scaffold proteins

    Wenbin Wan, Lan Cao, Lumei Liu, Chunyan Zhang, Bill Kalionis, Xiantao Tai, Yaming Li and Shijin Xia

    Article first published online: 24 APR 2015 | DOI: 10.1111/jnc.13122

    Thumbnail image of graphical abstract

    To reveal the role of RAGE in blood–brain barrier (BBB) disruption in Alzheimer's disease (AD), we employed an monolayer BBB model comprising bEnd.3 cell and found that BBB leakage was induced by treatment with amyloid-β (Aβ), and the levels of tight junction (TJ) scaffold proteins including ZO-1, Claudin-5, and Occludin were decreased. Using receptor for advanced glycation end-products (RAGE) neutralizing polyclonal antibody and siRNA, we confirmed that RAGE played an important role in Aβ-induced BBB leakage and alterations of TJ scaffold proteins and in the up-regulation of matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9). NF-κB, nuclear factor kappa-light-chain-enhancer of activated B cells.