Journal of Neurochemistry

Cover image for Vol. 144 Issue 3

Edited By: Jörg Schulz

Impact Factor: 4.083

ISI Journal Citation Reports © Ranking: 2016: 66/259 (Neurosciences); 78/290 (Biochemistry & Molecular Biology)

Online ISSN: 1471-4159

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Recently Published Articles

  1. Adenosine A2A receptors are required for glutamate mGluR5- and dopamine D1 receptor-evoked ERK1/2 phosphorylation in rat hippocampus: involvement of NMDA receptor

    Paraskevi Krania, Eleni Dimou, Maria Bantouna, Stylianos Kouvaros, Eirini Tsiamaki, Costas Papatheodoropoulos, Konstantinos Sarantis and Fevronia Angelatou

    Version of Record online: 23 JAN 2018 | DOI: 10.1111/jnc.14268

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    Metabotropic glutamate 5 receptors (mGluR5) and N-methyl-d-aspartate receptor (NMDAR) interaction is vital for synaptic plasticity and cognition. mGluR5 and NMDAR synergistically stimulate ERK1/2 (extracellular signal-regulated protein kinase 1/2) phosphorylation in rat hippocampus, requiring the adenosine A2A receptor activation and NR2B(Tyr1472) phosphorylation, which are also required for dopamine D1 receptor-evoked ERK1/2 activation. In line with this, our electrophysiological data show that theta burst stimulation-induced long-term potentiation (LTP) in the hippocampal CA1 region increases ERK1/2 activation and that both phenomena are dependent on the tripartite A2AR, mGluR5, and NMDAR.

  2. Corticotropin-releasing hormone-binding protein is upregulated by brain-derived neurotrophic factor and is secreted in an activity-dependent manner in rat cerebral cortical neurons

    Naoki Adachi, Shingo Suzuki, Hidetada Matsuoka, Satoko Fushimi, Junichiro Ono, Ken-ichi Ohta, Yohei Hirai, Takanori Miki and Hisatsugu Koshimizu

    Accepted manuscript online: 22 JAN 2018 03:03AM EST | DOI: 10.1111/jnc.14310

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    Complex neuroprotective and neurotoxic effects of histone deacetylases

    Elizabeth A. Thomas and Santosh R. D'Mello

    Accepted manuscript online: 22 JAN 2018 02:41AM EST | DOI: 10.1111/jnc.14309

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    An emerging role of astrocytes in vascular contributions to cognitive impairment and dementia

    Brittani R. Price, Christopher M. Norris, Pradoldej Sompol and Donna M. Wilcock

    Version of Record online: 22 JAN 2018 | DOI: 10.1111/jnc.14273

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    We propose that hyperhomocysteinemia (HHcy) results in a pro-inflammatory response at the vasculature, which activates the matrix metalloproteinase MMP9. MMP9 subsequently cleaves the a-b dystroglycan complex, leading to disruption of the astrocytic connection with the vasculature. MMP9 also degrades the dystrophin Dp71 anchoring complex, resulting in the down-regulation of astrocytic end-foot channels. The end result of the end-foot disruption is impaired potassium homeostasis in the brain and impaired neurovascular coupling.

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    Mitochondrial function and autophagy: integrating proteotoxic, redox, and metabolic stress in Parkinson's disease

    Jianhua Zhang, M Lillian Culp, Jason G Craver and Victor Darley-Usmar

    Accepted manuscript online: 17 JAN 2018 07:35AM EST | DOI: 10.1111/jnc.14308