Journal of Neurochemistry

Cover image for Vol. 133 Issue 5

Edited By: Jörg Schulz

Impact Factor: 4.244

ISI Journal Citation Reports © Ranking: 2013: 63/252 (Neurosciences); 74/291 (Biochemistry & Molecular Biology)

Online ISSN: 1471-4159

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Recently Published Articles

  1. Striatal-enriched protein tyrosine phosphatase regulates the PTPα/Fyn signaling pathway

    Jian Xu, Pradeep Kurup, Ethan Foscue and Paul J. Lombroso

    Article first published online: 25 MAY 2015 | DOI: 10.1111/jnc.13160

    Thumbnail image of graphical abstract

    STEP61, PTPα, Fyn, and NMDA receptor (NMDAR) have been implicated in ethanol intake behaviors in the dorsomedial striatum (DMS) in rodents. Here, we report that PTPα is a novel substrate for STEP61. Upon ethanol exposure, STEP61 is phosphorylated and inactivated by protein kinase A (PKA) signaling in the DMS. As a result of STEP61 inhibition, there is an increase in the phosphorylation of PTPα, which translocates to lipid rafts and activates Fyn and subsequent NMDAR signaling. The results demonstrate a synergistic regulation of Fyn-NMDAR signaling by STEP61 and PTPα, which may contribute to the regulation of ethanol-related behaviors. NMDA, N-methyl-d-aspartate; PTPα, receptor-type protein tyrosine phosphatase alpha; STEP, STriatal-Enriched protein tyrosine Phosphatase.

  2. The RAGE receptor and its ligands are highly expressed in astrocytes in a grade-dependant manner in the striatum and subependymal layer in Huntington's disease

    Joanne Kim, Henry J Waldvogel, Richard LM Faull, Maurice A Curtis and Louise FB Nicholson

    Accepted manuscript online: 23 MAY 2015 09:12AM EST | DOI: 10.1111/jnc.13178

  3. Optogenetic versus electrical stimulation of dopamine terminals in the Nucleus accumbens elicits local modulation of presynaptic release

    James R. Melchior, Mark J. Ferris, Garret D Stuber, David R. Riddle and Sara R. Jones

    Accepted manuscript online: 23 MAY 2015 09:12AM EST | DOI: 10.1111/jnc.13177

  4. The Mitochondrial Uncoupler DNP Triggers Brain Cell mTOR Signaling Network Reprogramming and CREB Pathway Upregulation

    Dong Liu, Yongqing Zhang, Robert Gharavi, Hee Ra Park, Jaewon Lee, Sana Siddiqui, Richard Telljohann, Matthew R. Nassar, Roy G. Cutler, Kevin G. Becker and Mark P. Mattson

    Accepted manuscript online: 23 MAY 2015 08:57AM EST | DOI: 10.1111/jnc.13176

  5. You have free access to this content
    A central role for the acid sphingomyelinase/ceramide system in neurogenesis and major depression

    Erich Gulbins, Silke Walter, Katrin Anne Becker, Ramona Halmer, Yang Liu, Martin Reichel, Michael J. Edwards, Christian P. Müller, Klaus Fassbender and Johannes Kornhuber

    Article first published online: 23 MAY 2015 | DOI: 10.1111/jnc.13145

    Thumbnail image of graphical abstract

    Major depressive disorder is a severe and chronic illness with high lifetime prevalence and high incidence of suicide. Major depression is caused in part by an imbalance between factors that positively and negatively control neurogenesis. Anti-depressants inhibit the acid sphingomyelinase/ceramide system and thereby reduce the sum of negative factors restoring neurogenesis, neuronal survival, and improved mood.