Journal of Neurochemistry

Cover image for Vol. 133 Issue 4

Edited By: Jörg Schulz

Impact Factor: 4.244

ISI Journal Citation Reports © Ranking: 2013: 63/252 (Neurosciences); 74/291 (Biochemistry & Molecular Biology)

Online ISSN: 1471-4159

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Recently Published Articles

  1. The regulation of p53 upregulated modulator of apoptosis (Puma) by JNK/c-Jun pathway in β-amyloid induced neuron death

    Rumana Akhter, Priyankar Sanphui, Hrishita Das, Pampa Saha and Subhas Chandra Biswas

    Accepted manuscript online: 17 APR 2015 09:08AM EST | DOI: 10.1111/jnc.13128

  2. Kisspeptin1 modulates odorant-evoked fear response via two serotonin receptor subtypes (5-HT1A and 5-HT2) in zebrafish

    Fatima M. Nathan, Satoshi Ogawa and Ishwar S. Parhar

    Article first published online: 17 APR 2015 | DOI: 10.1111/jnc.13105

    Thumbnail image of graphical abstract

    Kiss1 peptide intracranially (IC) administrated has been shown to decrease olfactory, alarm substance (AS)-evoked fear response. Blockade of the 5-HT1A receptor utilizing WAY 100635 (0.28 mg/kg) and the 5-HT1 and 5-HT2 receptor utilizing methysergide (92.79 mg/kg) produced increased AS-evoked fear responses that were unable to be overcome even during the recovery period. Blockade of this 5-HT system followed by Kiss1 administration showed that the peptide was unable to recover the anxiolytic effects upon 5-HT1A blocking using WAY 100635 with the exception of freezing behaviour while methysergide significantly blocked all the anxiolytic effects of Kiss1. These findings implicate that Kiss1 could modulate AS-evoked fear responses mediated by 5-HT1A and 5-HT2 receptors.

  3. Regulation of peroxisome proliferator-activated receptors (PPAR) α and -γ of rat brain astrocytes in the course of activation by toll-like receptor agonists

    Dmitry V. Chistyakov, Stepan E. Aleshin, Alina A. Astakhova, Marina G. Sergeeva and Georg Reiser

    Article first published online: 16 APR 2015 | DOI: 10.1111/jnc.13101

    Thumbnail image of graphical abstract

    Astrocytes have the triad of PPARα, PPARβ/δ, and PPARγ in regulation of proinflammatory responses. Activation of Toll-like receptors (TLR) leads to PPARβ/δ overexpression, PPARα and PPARγ suppression via TLR/NF-κB pathway on mRNA, protein and activity levels. Mitogen-activated protein kinases (MAPK) p38 and JNK are involved in regulation of PPAR expression. p38 MAPK plays a special role in stabilization of PPAR mRNA.

  4. Molecular mechanism of monoamine oxidase A gene regulation under inflammation and ischemia-like conditions: key roles of the transcription factors GATA2, Sp1 and TBP

    Vinayak Gupta, Abrar A. Khan, Binu K. Sasi and Nitish R. Mahapatra

    Article first published online: 16 APR 2015 | DOI: 10.1111/jnc.13099

    Thumbnail image of graphical abstract

    Dysregulation of monoamine oxidase A (MAOA) have been implicated in several behavioral and neuronal disease states. Here, we identified three crucial transcription factors (GATA2, Sp1 and TBP) that regulate MAOA gene expression in a coordinated manner. Aberrant MAOA expression under pathophysiological conditions including inflammation and ischemia is mediated by altered binding of GATA2/Sp1/TBP with MAOA proximal promoter. Thus, these findings provide new insights into pathogenesis of several common diseases. GATA2, GATA-binding protein 2; Sp1, specificity protein 1; TBP, TATA-binding protein.

  5. Neuroprotective effects of Argon are mediated via an ERK-1/2 dependent regulation of heme-oxygenase-1 in retinal ganglion cells

    Felix Ulbrich, Kai B. Kaufmann, Mark Coburn, Wolf Alexander Lagrèze, Martin Roesslein, Julia Biermann, Hartmut Buerkle, Torsten Loop and Ulrich Goebel

    Accepted manuscript online: 15 APR 2015 08:56PM EST | DOI: 10.1111/jnc.13115