Journal of Neurochemistry

Cover image for Vol. 129 Issue 2

Edited By: Jörg Schulz

Impact Factor: 3.973

ISI Journal Citation Reports © Ranking: 2012: 71/252 (Neurosciences); 83/290 (Biochemistry & Molecular Biology)

Online ISSN: 1471-4159

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Recently Published Articles

  1. Rufy3, a protein specifically expressed in neurons, interacts with actin-bundling protein Fascin to control the growth of axons

    Zhe Wei, Ming Sun, Xinyi Liu, Jian Zhang and Ying Jin

    Accepted manuscript online: 10 APR 2014 11:17AM EST | DOI: 10.1111/jnc.12740

  2. A mutation protective against Alzheimer's disease renders amyloid β precursor protein incapable of mediating neurotoxicity

    Yuichi Hashimoto and Masaaki Matsuoka

    Article first published online: 9 APR 2014 | DOI: 10.1111/jnc.12717

    Thumbnail image of graphical abstract

    The A598T mutation of amyloid precursor protein APP is linked to a reduction in the incidence rate of Alzheimer's disease (AD). This study shows that TGFβ2 causes death in neuronal cells expressing wild-type APP, but not in those expressing the AD-protective mutant of APP, suggesting that the AD-protective mutation of APP reduces the incidence rate of AD by attenuating the APP-mediated intracellular death signal.

  3. 3D Electrospun scaffolds promote a cytotrophic phenotype of cultured primary astrocytes

    Chew L. Lau, Michelle Kovacevic, Tine S. Tingleff, John S. Forsythe, Holly S. Cate, Daniel Merlo, Cecilia Cederfur, Francesca L. Maclean, Clare L. Parish, Malcolm K. Horne, David R. Nisbet and Philip M. Beart

    Article first published online: 9 APR 2014 | DOI: 10.1111/jnc.12702

    Thumbnail image of graphical abstract

    Astrocytes exist in phenotypes with pro-survival and destructive components, and their biology can be modulated by changing phenotype. Our findings demonstrate murine astrocytes adopt a healthy phenotype when cultured in 3D. Astrocytes proliferate and extend into poly-ε-caprolactone scaffolds displaying 3D stellated morphologies with reduced GFAP expression and actin stress fibres, plus a cytotrophic gene profile. Bioengineered 3D scaffolds have potential to direct inflammation to aid regenerative neurobiology.

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    Iron Dysregulation in Huntington's Disease

    Michelle Muller and Blair R. Leavitt

    Accepted manuscript online: 9 APR 2014 07:50AM EST | DOI: 10.1111/jnc.12739

  5. The voltage-gated calcium channel blocker lomerizine is neuroprotective in motor neurons expressing mutant SOD1, but not TDP-43

    Luan T. Tran, Benoit J. Gentil, Kathleen E. Sullivan and Heather D. Durham

    Accepted manuscript online: 9 APR 2014 07:50AM EST | DOI: 10.1111/jnc.12738