Journal of Neurochemistry

Cover image for Vol. 134 Issue 3

Edited By: Jörg Schulz

Impact Factor: 4.281

ISI Journal Citation Reports © Ranking: 2014: 55/252 (Neurosciences); 72/289 (Biochemistry & Molecular Biology)

Online ISSN: 1471-4159

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Recently Published Articles

  1. Tissue transglutaminase-catalysed cross-linking induces Apolipoprotein E multimers inhibiting Apolipoprotein E's protective effects towards amyloid-beta-induced toxicity

    Mieke de Jager, Benjamin Drukarch, Marloes Hofstee, John Brevé, Cornelis A. M. Jongenelen, John G. J. M. Bol and Micha M. M. Wilhelmus

    Article first published online: 7 JUL 2015 | DOI: 10.1111/jnc.13203

    Thumbnail image of graphical abstract

    Cerebral amyloid angiopathy (CAA) is a pathological hallmark of Alzheimer's disease (AD) and characterized by amyloid-β (Aβ) protein deposition and cerebral smooth muscle cell (SMC) death. We found that, in contrast to normal vessels, in CAA apolipoprotein E (ApoE) is cross-linked by tissue transglutaminase (tTG) resulting in stable ApoE complexes. These complexes no longer protect cerebral SMC from Aβ-mediated toxicity. Our findings demonstrate a novel mechanism explaining the Aβ-mediated cerebral SMC cell death characteristic of CAA in AD cases.

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  3. Upregulation of c-Jun NH2-terminal kinase-interacting protein 3 (JIP3) contributes to BDNF-enhanced neurotransmitter release

    Bing Chen, Xin-Liang Ma, Zhao Geng, Shu-Hong Huang, Lu-Kai Zhai, Yun-Yun Guo and Zhe-Yu Chen

    Accepted manuscript online: 6 JUL 2015 09:27AM EST | DOI: 10.1111/jnc.13226

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    Shank synaptic scaffold proteins: keys to understanding the pathogenesis of autism and other synaptic disorders

    Carlo Sala, Cinzia Vicidomini, Ilaria Bigi, Adele Mossa and Chiara Verpelli

    Accepted manuscript online: 6 JUL 2015 09:26AM EST | DOI: 10.1111/jnc.13232