Journal of Neurochemistry

Cover image for Vol. 132 Issue 3

Edited By: Jörg Schulz

Impact Factor: 4.244

ISI Journal Citation Reports © Ranking: 2013: 63/252 (Neurosciences); 74/291 (Biochemistry & Molecular Biology)

Online ISSN: 1471-4159

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Recently Published Articles

  1. Ligand-directed delivery of fluorophores to track native calcium-permeable AMPA receptors in neuronal cultures

    Rosamund E. Combs-Bachmann, Jeffreys Nate Johnson, Devaiah Vytla, Amanda M. Hussey, Maria L. Kilfoil and James J. Chambers

    Accepted manuscript online: 1 FEB 2015 06:18AM EST | DOI: 10.1111/jnc.13051

  2. Peripheral adipose tissue insulin resistance alters lipid composition and function of hippocampal synapses

    Hanaa S. Sallam, Batbayar Tumurbaatar, Wen-Ru Zhang, Demidmaa Tuvdendorj, Manisha Chandalia, Filippo Tempia, Fernanda Laezza, Giulio Taglialatela and Nicola Abate

    Accepted manuscript online: 1 FEB 2015 06:17AM EST | DOI: 10.1111/jnc.13043

  3. Protein kinase A directly phosphorylates metabotropic glutamate receptor 5 to modulate its function

    Ken Uematsu, Myriam Heiman, Marina Zelenina, Júlio Padovan, Brian T. Chait, Anita Aperia, Akinori Nishi and Paul Greengard

    Accepted manuscript online: 1 FEB 2015 06:06AM EST | DOI: 10.1111/jnc.13038

  4. Clozapine influences cytoskeleton structure and calcium homeostasis in rat cerebral cortex and has a different proteomic profile than risperidone

    Sylwia Kedracka-Krok, Bianka Swiderska, Urszula Jankowska, Bozena Skupien-Rabian, Joanna Solich, Katarzyna Buczak and Marta Dziedzicka-Wasylewska

    Article first published online: 30 JAN 2015 | DOI: 10.1111/jnc.13007

    Thumbnail image of graphical abstract

    Using two-dimensional differential electrophoresis, we demonstrate that chronic treatment the healthy rats with anti-psychotics, clozapine and risperidone, induce changes in expression of cytoskeletal, synaptic, and regulatory proteins in the cerebral cortex. While risperidone increases the level of proteins regulating cell proliferation, namely, fatty acid-binding protein-7 and translin-associated factor X, the clozapine significantly up-regulates calcium sensors, i.e., visinin-like protein 1 and neurocalcin δ. 2D DIGE, Differential in Gel Electrophoresis; Cy2, Cy3, and Cy5 are cyanine dyes.

  5. COB231 targets amyloid plaques in post-mortem human brain tissue and in an Alzheimer mouse model

    Dominique Garin, Angélique Virgone-Carlotta, Bülent Gözel, Fatima Oukhatar, Pascale Perret, Danièle Marti-Battle, Monique Touret, Philippe Millet, Michel Dubois-Dauphin, David Meyronet, Nathalie Streichenberger, Frank M. Laferla, Martine Demeunynck, Sabine Chierici, Marcelle Moulin Sallanon and Catherine Ghezzi

    Article first published online: 30 JAN 2015 | DOI: 10.1111/jnc.12951

    Thumbnail image of graphical abstract

    Previous work has shown that naturally fluorescent proflavine derivatives label Abeta plaques. Our aim was to further characterize the properties of one of them: 3-acetylamino-6-[3-(propargylamino) propanoyl]aminoacridine (COB231). We demonstrated the Abeta deposit binding properties of COB231 in vitro on Alzheimer (AD) patient brain slices (see image showing COB231 labelling of Abeta deposits), and in vivo in an AD mice model. These results are particularly attractive with regard to the flexible chemistry of COB231 that allows further radiolabelling for in vivo imaging or combination with a therapeutic agent targeting Abeta aggregates.