Journal of Neurochemistry

Cover image for Vol. 138 Issue 2

Edited By: Jörg Schulz

Impact Factor: 3.842

ISI Journal Citation Reports © Ranking: 2015: 71/256 (Neurosciences); 83/289 (Biochemistry & Molecular Biology)

Online ISSN: 1471-4159

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Recently Published Articles

  1. Loss of divalent metal transporter 1 function promotes brain copper accumulation and increases impulsivity

    Murui Han, JuOae Chang and Jonghan Kim

    Version of Record online: 22 JUL 2016 | DOI: 10.1111/jnc.13717

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    Iron-copper model: Mutations in the divalent metal transporter 1 (DMT1) decrease body iron status and up-regulate copper absorption, which leads to copper loading in the brain and consequently increases metal-induced oxidative stress. This event disrupts GABAergic neurotransmission and promotes impulsivity-like behavior. Our model provides better understanding of physiological risks associated with imbalanced metal metabolism in mental function and, more specifically, the interactions with GABA and redox control in the treatment of emotional disorders.

  2. Haptoglobin increases the vulnerability of CD163-expressing neurons to hemoglobin

    Jing Chen-Roetling and Raymond F. Regan

    Version of Record online: 22 JUL 2016 | DOI: 10.1111/jnc.13720

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    Haptoglobin (Hp) binds hemoglobin (Hb) with high affinity and provides the primary defense against its toxicity after intravascular hemolysis. Neurons are exposed to extracellular Hb after CNS hemorrhage, and a therapeutic effect of Hp via Hb sequestration has been hypothesized. In this study, we tested the hypothesis that Hp protects neurons from Hb in primary mixed cortical cell cultures. Binding of hemoglobin to haptoglobin directs Hb to CD163 +  neurons and microglia and away from astrocytes. This decreases expression of ferritin by astrocytes and increases neuronal injury.

  3. Proteolysis of α-Synuclein Fibrils in the Lysosomal Pathway Limits Induction of Inclusion Pathology

    Amanda N. Sacino, Mieu My Thi Brooks, Paramita Chakrabarty, Kaustuv Saha, Habibeh Khoshbouei, Todd E. Golde and Benoit I. Giasson

    Accepted manuscript online: 18 JUL 2016 03:40AM EST | DOI: 10.1111/jnc.13743

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    Role of GABAAR trafficking in the plasticity of inhibitory synapses

    Miranda Mele, Graciano Leal and Carlos B. Duarte

    Accepted manuscript online: 18 JUL 2016 03:40AM EST | DOI: 10.1111/jnc.13742

  5. Molecular mode of action of CGS 9895 at α1β2γ2GABAA receptors

    Maria C. Maldifassi, Roland Baur and Erwin Sigel

    Version of Record online: 18 JUL 2016 | DOI: 10.1111/jnc.13711

    Thumbnail image of graphical abstract

    GABAA receptors are the main inhibitory neurotransmitter receptors in the brain and are targets for numerous clinically important drugs such as benzodiazepines, anxiolytics and anesthetics. We have identified the α1 Y209 residue present at the extracellular α+/β− subunit interface as a key residue for the positive allosteric modulation of the GABAA receptor by CGS 9895. This receptor harbors additional modulatory sites for this compound at subunit interfaces in the transmembrane domain.

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