Journal of Neurochemistry

Cover image for Vol. 130 Issue 3

Edited By: Jörg Schulz

Impact Factor: 4.244

ISI Journal Citation Reports © Ranking: 2013: 63/251 (Neurosciences); 74/291 (Biochemistry & Molecular Biology)

Online ISSN: 1471-4159

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Recently Published Articles

  1. Elevation of striatal urate in experimental models of Parkinson's disease: a compensatory mechanism triggered by dopaminergic nigrostriatal degeneration?

    Maria Antonietta De Luca, Omar Cauli, Micaela Morelli and Nicola Simola

    Article first published online: 30 JUL 2014 | DOI: 10.1111/jnc.12809

    Thumbnail image of graphical abstract

    This study evaluated the in vivo modifications in the striatal urate levels in the mouse MPTP and the rat 6-OHDA models of Parkinson's disease-like dopaminergic nigrostriatal toxicity. The results obtained demonstrated that dopaminergic neurotoxicity is associated with higher urate levels in the striatum, which would strengthen the idea of a link between endogenous urate and Parkinson's disease.

  2. Amphetamine potency varies with dopamine uptake rate across striatal subregions

    Cody A. Siciliano, Erin S. Calipari and Sara R. Jones

    Article first published online: 30 JUL 2014 | DOI: 10.1111/jnc.12808

    Thumbnail image of graphical abstract

    Amphetamine is a central nervous system psychostimulant with a high potential for abuse, which may be augmented by increased dopamine transporter (DAT) expression. We here show that the ability of amphetamine to inhibit dopamine (DA) transport and deplete dopamine vesicles increases in a graded manner across striatal subregions from ventral to dorsal with the greatest effects on DA neurotransmission in the dorsal caudate-putamen. Additionally, DA uptake rate and amphetamine potency positively correlated, suggesting that differences across regions result from disparate DA transporter levels.

  3. Striatal Serotonin 2C receptors decrease nigrostriatal dopamine release by increasing GABA-A receptor tone in the substantia nigra

    M.V. Burke, C. Nocjar, A.J. Sonneborn, A.C. McCreary and E.A. Pehek

    Accepted manuscript online: 29 JUL 2014 08:42AM EST | DOI: 10.1111/jnc.12842

  4. Pleiotrophin differentially regulates the rewarding and sedative effects of ethanol

    Marta Vicente-Rodríguez, Carmen Pérez-García, Marcel Ferrer-Alcón, María Uribarri, María G. Sánchez-Alonso, María P. Ramos and Gonzalo Herradón

    Accepted manuscript online: 29 JUL 2014 08:42AM EST | DOI: 10.1111/jnc.12841