Journal of Neurochemistry

Cover image for Vol. 132 Issue 1

Edited By: Jörg Schulz

Impact Factor: 4.244

ISI Journal Citation Reports © Ranking: 2013: 63/252 (Neurosciences); 74/291 (Biochemistry & Molecular Biology)

Online ISSN: 1471-4159

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Recently Published Articles

  1. You have free access to this content
    Complementary roles of the neuron-enriched endosomal proteins NEEP21 and calcyon in neuronal vesicle trafficking (pages 20–31)

    Nagendran Muthusamy, Yong-Jun Chen, Dong-Min Yin, Lin Mei and Clare Bergson

    Article first published online: 17 DEC 2014 | DOI: 10.1111/jnc.12989

    Thumbnail image of graphical abstract

    This review focuses on two closely related, neuron-enriched endosomal proteins: NEEP21 and Calcyon which perform distinct roles in regulating receptor endocytosis, recycling, and degradation. Based on an in-depth examination of the literature, we argue that these two proteins carry out complementary yet sometimes opposing vesicle trafficking functions that impact excitatory transmission, transcytosis, axonal transport, and also proteolytic processing by beta-secretase I (BACE1). Finally, we propose that balancing NEEP21 and Calcyon expression and/or activity could be important for homeostasis in a variety of signaling pathways, and also lead to a novel therapeutic strategy for disorders like Alzheimer's disease and schizophrenia. AMPA = α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor; NMDA = N-Methyl-D-aspartate.

  2. Polyphenols from green tea prevent antineuritogenic action of Nogo-A via 67-kDa laminin receptor and hydrogen peroxide (pages 70–84)

    Usha Gundimeda, Thomas H. McNeill, Barsegh A. Barseghian, William S. Tzeng, David V. Rayudu, Enrique Cadenas and Rayudu Gopalakrishna

    Article first published online: 17 DEC 2014 | DOI: 10.1111/jnc.12964

    Thumbnail image of graphical abstract

    Currently, several agents are being evaluated for overcoming axonal growth inhibitors to promote functional recovery after stroke and spinal cord injury. Epigallocatechin-3-gallate (EGCG), present in green tea polyphenol mixture (GTPP), prevents antineuritogenic activity of Nogo-A, a myelin-derived axonal growth inhibitor. The preventive action of EGCG involves the cell-surface-associated 67-kDa laminin receptor and H2O2. GTPP may complement ongoing efforts to treat neuronal injuries.

  3. You have free access to this content
  4. Susceptibility to excitotoxicity in aged hippocampal cultures and neuroprotection by non-steroidal anti-inflammatory drugs: role of mitochondrial calcium

    María Calvo, Sara Sanz-Blasco, Erica Caballero, Carlos Villalobos and Lucía Núñez

    Accepted manuscript online: 9 DEC 2014 08:28AM EST | DOI: 10.1111/jnc.13004

  5. Rapid mitochondrial dysfunction mediates TNF-alpha-induced neurotoxicity

    Danielle N. Doll, Stephanie L. Rellick, Taura L. Barr, Xuefang Ren and James W. Simpkins

    Accepted manuscript online: 9 DEC 2014 08:27AM EST | DOI: 10.1111/jnc.13008