Journal of Neurochemistry
© International Society for Neurochemistry
Edited By: Jörg Schulz
Impact Factor: 3.973
ISI Journal Citation Reports © Ranking: 2012: 71/252 (Neurosciences); 83/290 (Biochemistry & Molecular Biology)
Online ISSN: 1471-4159
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Recently Published Articles
- Activation of rhodopsin gene transcription in cultured retinal precursors of chicken embryo: role of Ca2+ signaling and hyperpolarization-activated cation channels
Marianne Bernard, Camille Dejos, Thierry Bergès, Matthieu Régnacq and Pierre Voisin
Article first published online: 11 DEC 2013 | DOI: 10.1111/jnc.12624
Rhodopsin gene expression in cultured retinal precursors from chicken embryo relies on a Ca2+-dependent mechanism whereby hyperpolarization-activated cyclic nucleotide-gated channels (HCN) activate T-type voltage-dependent Ca2+ channels (VDCC) through membrane depolarization, causing calmodulin-dependent kinase II (CaMKII) to phosphorylate the cAMP-responsive element-binding protein (CREB) and leading to activation of rhodopsin gene transcription. Photoreceptor localization and development of HCN1 channels suggest similar role in vivo.
- You have free access to this contentMicrotubules in neurons as information carriers
Erik W. Dent and Peter W. Baas
Article first published online: 11 DEC 2013 | DOI: 10.1111/jnc.12621
We review here the possibility of neuronal microtubules acting as “information carriers”, conveying biochemical factors within axons and dendrites. The more dynamic regions of longer microtubules associate at their plus ends with information-rich proteins called +TIPs that can be deposited or interact with other proteins or structures encountered by the microtubule as it assembles. Short stable microtubules that transit within the axon (and presumably the dendrite) may also serve as vehicles for the delivery of such information. Microtubules are broadly known for their roles in architecture and transport, and we posit that such a role as information carriers may be a third major role for microtubules in neurons.
- In vitro Characterization of a small molecule inhibitor of the alanine serine cysteine transporter -1 (SLC7A10)
Jeffrey M. Brown, Lisa Hunihan, Margaret M. Prack, David G. Harden, Joanne Bronson, Carolyn D. Dzierba, Robert G. Gentles, Adam Hendricson, Rudy Krause, John E. Macor and Ryan S. Westphal
Article first published online: 10 DEC 2013 | DOI: 10.1111/jnc.12618
Enhancing NMDA function by increasing synaptic D-serine is a proposed therapeutic approach for the treatment of schizophrenia. Synaptic D-serine levels are regulated by the alanine, serine, cysteine transporter 1 (asc-1). The following study describes the first novel asc-1 inhibitor, Compound 1 (BMS-466442), and provides a path forward for the development of additional asc-1 inhibitors.
- Molecular, pharmacological, and signaling properties of octopamine receptors from honeybee (Apis mellifera) brain
Sabine Balfanz, Nadine Jordan, Teresa Langenstück, Johanna Breuer, Vera Bergmeier and Arnd Baumann
Article first published online: 10 DEC 2013 | DOI: 10.1111/jnc.12619
The biogenic amine octopamine is an important modulator of behavior and physiology in arthropods. Binding of octopamine to specific G protein-coupled receptors causes elevation of [Ca2+]i or [cAMP]i. Only one honeybee octopamine receptor inducing Ca2+ signals has been experimentally characterized, yet. Here, we present the pharmacological properties of four additional members of the honeybee octopamine receptor family causing cAMP production.
- Ethanol, not detectably metabolized in brain, significantly reduces brain metabolism, probably via action at specific GABA(A) receptors and has measureable metabolic effects at very low concentrations
Caroline D. Rae, Joanne E. Davidson, Anthony D. Maher, Benjamin D. Rowlands, Mohammed A. Kashem, Fatima A. Nasrallah, Sundari K. Rallapalli, James M Cook and Vladimir J. Balcar
Accepted manuscript online: 7 DEC 2013 09:11AM EST | DOI: 10.1111/jnc.12634