Journal of Neurochemistry
© International Society for Neurochemistry
Edited By: Jörg Schulz
Impact Factor: 3.973
ISI Journal Citation Reports © Ranking: 2012: 71/252 (Neurosciences); 83/290 (Biochemistry & Molecular Biology)
Online ISSN: 1471-4159
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Recently Published Articles
- DJ-1 deficiency triggers microglia sensitivity to dopamine towards a pro-inflammatory phenotype that is attenuated by rasagiline
Dorit Trudler, Orly Weinreb, Silvia A. Mandel, Moussa B. H. Youdim and Dan Frenkel
Accepted manuscript online: 6 DEC 2013 09:55AM EST | DOI: 10.1111/jnc.12633
- Ischemic neurons activate astrocytes to disrupt endothelial barrier via increasing VEGF expression
Ying-Na Li, Rong Pan, Xu-Jun Qin, Wei-Lin Yang, Zhifeng Qi, Wenlan Liu and Ke Jian Liu
Article first published online: 6 DEC 2013 | DOI: 10.1111/jnc.12611
Little is known about the contribution of neurons to blood–brain barrier (BBB) injury following cerebral ischemia. Using co-culture model of neurons, astrocytes and endothelial cells, we found that ischemic neurons activated astrocytes to increase vascular endothelial growth factor (VEGF) secretion that in turns acted on tight junction proteins to increase BBB permeability. These results clearly suggest an important role of neurons in ischemic BBB damage.
- The role of NMDA and mGluR5 receptors in calcium mobilization and neurotoxicity of homocysteine in trigeminal and cortical neurons and glial cells
Polina A. Abushik, Minna Niittykoski, Raisa Giniatullina, Anastasia Shakirzyanova, Genevieve Bart, Dmitriy Fayuk, Dmitry A. Sibarov, Sergei M. Antonov and Rashid Giniatullin
Article first published online: 4 DEC 2013 | DOI: 10.1111/jnc.12615
We show that NMDA and mGluR5 receptors in trigeminal and cortical neurons and mGluR5 receptors in glial cells mediate homocysteine (HCY)-induced [Ca2+]i elevation whereas HCY-evoked apoptosis involves both NMDA and mGluR5 receptors. This study revealed migraine-related short- and long-term effects of this redox active aminoacid within the nociceptive system and highlights potential targets for anti-nociception and neuroprotection.
- Vascular endothelial growth factor signaling in injured nerves underlies peripheral sensitization in neuropathic pain
Norikazu Kiguchi, Yuka Kobayashi, Yui Kadowaki, Yohji Fukazawa, Fumihiro Saika and Shiroh Kishioka
Article first published online: 4 DEC 2013 | DOI: 10.1111/jnc.12614
Angiogenesis due to VEGF signaling is a key component of chronic inflammation. VEGFA up-regulation and pathological angiogenesis were observed in the injured nerves in mice. Pharmacological inhibition of VEGF signaling suppressed neuropathic pain behaviors. Therefore, VEGFA-related components may underlie peripheral neuroinflammation leading to neuropathic pain.
- N-nitrosomelatonin enhances photic synchronization of mammalian circadian rhythms
Fernando M. Baidanoff, Santiago A. Plano, Fabio Doctorovich, Sebastián A. Suárez, Diego A. Golombek and Juan J. Chiesa
Article first published online: 4 DEC 2013 | DOI: 10.1111/jnc.12613
We demonstrated the chronobiotic effects of a novel nitric oxide donor, N-nitrosomelatonin (NO-Mel), which enhanced light-induced circadian entrainment and gene expression in the suprachiasmatic nuclei, the site of the mammalian biological clock, as well as promoted and accelerated rate of reentrainment to an experimental jetlag protocol. NO-Mel increased nitrate/nitrite levels in the SCN and we suggest our findings represent a novel strategy for the treatment of human circadian disorders.