Journal of Neurochemistry

Cover image for Vol. 140 Issue 5

Edited By: Jörg Schulz

Impact Factor: 3.842

ISI Journal Citation Reports © Ranking: 2015: 71/256 (Neurosciences); 83/289 (Biochemistry & Molecular Biology)

Online ISSN: 1471-4159

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Recently Published Articles

  1. Cerebrospinal fluid levels of catecholamines and its metabolites in Parkinson's disease: Effect of L-DOPA treatment and changes in levodopa-induced dyskinesia

    A D Andersen, M Blaabjerg, M Binzer, A Kamal, H Thagesen, T W Kjaer, E Stenager and J B Gramsbergen

    Accepted manuscript online: 28 FEB 2017 02:55AM EST | DOI: 10.1111/jnc.13997

  2. Peripheral viral challenge elevates extracellular glutamate in the hippocampus leading to seizure hypersusceptibility

    Holly C. Hunsberger, Gregory W. Konat and Miranda N. Reed

    Accepted manuscript online: 28 FEB 2017 02:51AM EST | DOI: 10.1111/jnc.13999

  3. Neuroprotection and endocytosis: erythropoietin receptors in insect nervous systems

    Natasa Miljus, Bita Massih, Marissa A. Weis, Jan Vincent Rison, Christel B. Bonnas, Inge Sillaber, Hannelore Ehrenreich, Bart R. H. Geurten and Ralf Heinrich

    Version of Record online: 28 FEB 2017 | DOI: 10.1111/jnc.13967

    Thumbnail image of graphical abstract

    We demonstrate that erythropoietin and its neuroprotective non-erythropoietic splice variant EV-3 exert neuroprotective functions on primary cultured locust brain neurons by activating the transcription factor STAT, leading to the expression of anti-apoptotic factors. Binding of Epo or EV-3 to the neuroprotective receptor initiates endocytotic internalization of the ligand-receptor complex. The shared functions of Epo and EV-3 in insect and mammalian neurons suggest the existence of a shared ancient Epo-like signalling system involved in neuroprotection.

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    Linking amyotrophic lateral sclerosis and spinal muscular atrophy through RNA-transcriptome homeostasis: a genomics perspective

    Margarida Gama-Carvalho, Marina L. Garcia-Vaquero, Francisco R. Pinto, Florence Besse, Joachim Weis, Aaron Voigt, Jörg B. Schulz and Javier De Las Rivas

    Version of Record online: 28 FEB 2017 | DOI: 10.1111/jnc.13945

    Thumbnail image of graphical abstract

    Emerging intricate connections between four multifunctional proteins involved in RNA metabolism with a causal role in Amyotrophic Lateral Sclerosis and Spinal Muscular Atrophy – TDP-43, FUS, SMN, and Senataxin – highlight key biomolecular processes underlying these diseases and bring transcriptome homeostasis into the spotlight as a common theme in motor neuron degeneration.

  5. Differential regulation of sphingolipid metabolism in plasma, hippocampus, and cerebral cortex of mice administered sphingolipid modulating agents

    Corey Giles, Ryusuke Takechi, Natalie A. Mellett, Peter J. Meikle, Satvinder Dhaliwal and John C. Mamo

    Version of Record online: 28 FEB 2017 | DOI: 10.1111/jnc.13964

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    Substantiative evidence suggests sphingolipid metabolism is perturbed early in the development of neurodegenerative disorders. Peripheral sphingolipids are attractive biomarkers for predicting disease risk, however, it is not known how these relate to cerebral sphingolipid homeostasis. Using a suite of sphingolipid modulating agents, we describe the major pathways regulating sphingolipid metabolism in plasma, hippocampus, and cerebral cortex of mice.