Journal of Neurochemistry

Cover image for Vol. 130 Issue 6

Edited By: Jörg Schulz

Impact Factor: 4.244

ISI Journal Citation Reports © Ranking: 2013: 63/251 (Neurosciences); 74/291 (Biochemistry & Molecular Biology)

Online ISSN: 1471-4159

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Recently Published Articles

  1. Metabolomic comparison between cells overexpressing isocitrate dehydrogenase 1 and 2 mutants and the effects of an inhibitor on the metabolism

    He Wen, Hye Rim Cho, Taeho Yun, Hyeonjin Kim, Chul-Kee Park, Se-Hoon Lee, Seung Hong Choi and Sunghyouk Park

    Accepted manuscript online: 23 SEP 2014 03:01AM EST | DOI: 10.1111/jnc.12950

  2. LRRK2 Pathobiology in Parkinson's Disease

    Ian Martin, Jungwoo Wren Kim, Valina L. Dawson and Ted M. Dawson

    Accepted manuscript online: 23 SEP 2014 03:01AM EST | DOI: 10.1111/jnc.12949

  3. Larvae of the small white butterfly, Pieris rapae, express a novel serotonin receptor

    Yi-Xiang Qi, Ren-Ying Xia, Ya-Su Wu, David Stanley, Jia Huang and Gong-Yin Ye

    Article first published online: 23 SEP 2014 | DOI: 10.1111/jnc.12940

    Thumbnail image of graphical abstract

    We isolated a cDNA (Pr5-HT8) from larval Pieris rapae, which shares relatively low similarity to the known GPCRs. After heterologous expression in HEK293 cells, Pr5-HT8 mediated increased [Ca2+]i in response to low concentrations (< 10 nM) of 5-HT and various 5-HT receptor agonists. We found orthologs of Pr5-HT8 in some insect pests and vectors such as beetles and mosquitoes, but not in the genomes of honeybee, parasitoid wasps, or mammals.

  4. Continuous infusion of substance P into rat striatum alleviates nociceptive behavior via phosphorylation of extracellular signal-regulated kinase 1/2

    Yoki Nakamura, Hiroki Izumi, Ryo Fukushige, Takumi Shimizu, Kyohei Watanabe, Norimitsu Morioka, Aldric Hama, Hiroyuki Takamatsu and Yoshihiro Nakata

    Article first published online: 23 SEP 2014 | DOI: 10.1111/jnc.12938

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    Noxious stimulation induces a slow-onset substance P (SP) release as a volume transmitter, activating extra-synaptic NK1 receptors, and evokes phosphorylation of extracellular signal-regulated kinase (ERK) 1/2. The SP-NK1-ERK1/2 system in the striatum decreases tonic nociception.

  5. You have full text access to this OnlineOpen article
    Epidermal fatty acid-binding protein protects nerve growth factor-differentiated PC12 cells from lipotoxic injury

    Jo-Wen Liu, Manuel Montero, Liming Bu and Marino De Leon

    Article first published online: 19 SEP 2014 | DOI: 10.1111/jnc.12934

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    Epidermal fatty acid-binding protein (E-FABP) may protect nerve cells from the damaging exposure to high levels of free fatty acids (FA). We show that E-FABP can neutralize the effects of reactive oxygen species (ROS) generated by the high levels of FA in the cell and protect PC12 cells from lipotoxic injuries common in Type 2 diabetes neuropathy. Potentially, E-FABP gene up-regulation may be mediated through the NFkB pathway and future studies are needed to further evaluate this proposition.