You have full text access to this Open Access content

Cancer Science

Cover image for Vol. 108 Issue 9

Edited By: Yusuke Nakamura

Impact Factor: 3.974

ISI Journal Citation Reports © Ranking: 2016: 68/217 (Oncology)

Online ISSN: 1349-7006

Recently Published Issues

See all


Increased Impact Factor 3.974 !
Read, cite the journal, or submit your paper to keep contributing to the success of Cancer Science.
Click here to access the TOP cited articles published in 2015-2016.

Download the Free App on your iPhone/iPad or Android today!




Open AccessAll articles published by Cancer Science are freely available to read, download and share. To cover the cost of publishing, a publication fee will be charged. Please refer to the article publication charges page for more details.
For inquires, contact

Open access


piR-823 contributes to colorectal tumorigenesis by enhancing the transcriptional activity of HSF1
Jie Yin, Xiao-Yu Jiang, et al.

Characterization of V-set and immunoglobulin domain containing 1 exerting a tumor suppressor function in gastric, lung, and esophageal cancer cells
Yusuke Inoue, Shun Matsuura, et al.

Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands
Norihito Shibata, Naoki Miyamoto, et al.

Upregulation of ASAP3 contributes to colorectal carcinogenesis and indicates poor survival outcome
Haiying Tian, Jin Qian, et al.

Puquitinib, a novel orally available PI3Kδ inhibitor, exhibits potent antitumor efficacy against acute myeloid leukemia
Chengying Xie, Ye He, et al.

Endothelium originated from colorectal cancer stem cells constitute cancer blood vessels
Wenqi Shangguan, Chuanwen Fan, et al.

CLDN8, an androgen-regulated gene, promotes prostate cancer cell proliferation and migration
Daisaku Ashikari, Ken-ichi Takayama, et al.

Programmed death-ligand 1 expression at tumor invasive front is associated with epithelial-mesenchymal transition and poor prognosis in esophageal squamous cell carcinoma
Satoshi Tsutsumi, Hiroshi Saeki, et al.

Exome sequencing deciphers a germline MET mutation in familial epidermal growth factor receptor-mutant lung cancer
Naoki Tode, Toshiaki Kikuchi, et al.

Extracellular vesicles as trans-genomic agents: Emerging roles in disease and evolution
Yumi Kawamura, Yusuke Yamamoto, et al.

Cytokine biomarkers to predict antitumor responses to nivolumab suggested in a phase 2 study for advanced melanoma
Naoya Yamazaki, Yoshio Kiyohara, et al.

Ets1 and ESE1 reciprocally regulate expression of ZEB1/ZEB2, dependent on ERK1/2 activity, in breast cancer cells
Nguyen Duy Sinh, Kaori Endo, et al.

Suppressors of cytokine signaling: Potential immune checkpoint molecules for cancer immunotherapy
Shunsuke Chikuma, Mitsuhiro Kanamori, et al.

Identification of FERM domain-containing protein 5 as a novel target of β-catenin/TCF7L2 complex
Chi Zhu, Kiyoshi Yamaguchi, et al.

Mitochondrial uncoupler exerts a synthetic lethal effect against β-catenin mutant tumor cells
Yuki Shikata, Masaki Kiga, et al.

Androgen-induced lncRNA POTEF-AS1 regulates apoptosis-related pathway to facilitate cell survival in prostate cancer cells
Aya Misawa, Ken-ichi Takayama, et al.

Cetuximab strongly enhances immune cell infiltration into liver metastatic sites in colorectal cancer
Yuka Inoue, Shoichi Hazama, et al.

Prediction and prioritization of neoantigens: integration of RNA sequencing data with whole-exome sequencing
Takahiro Karasaki, Kazuhiro Nagayama, et al.

Leukemogenic kinase FIP1L1-PDGFRA and a small ubiquitin-like modifier E3 ligase, PIAS1, form a positive cross-talk through their enzymatic activities
Makoto Ibata, Junko Iwasaki, et al.

Receptor tyrosine kinase amplification is predictive of distant metastasis in patients with oral squamous cell carcinoma
Yu Oikawa, Kei-ichi Morita, et al.

Clinicopathological significance of SPC18 in colorectal cancer: SPC18 participates in tumor progression
Takuya Hattori, Kazuhiro Sentani, et al.

NS5ABP37 inhibits liver cancer by impeding lipogenesis and cholesterogenesis
Shenghu Feng, Ming Han, et al.

Amphiregulin triggered epidermal growth factor receptor activation confers in vivo crizotinib-resistance of EML4-ALK lung cancer and circumvention by epidermal growth factor receptor inhibitors
Hirokazu Taniguchi, Shinji Takeuchi, et al.

EWSR1/ELF5 induces acute myeloid leukemia by inhibiting p53/p21 pathway
Akifumi Endo, Daisuke Tomizawa, et al.

Phase I trial of GBS-01 for advanced pancreatic cancer refractory to gemcitabine
Masafumi Ikeda, Akihiro Sato, et al.

CITED2 in breast carcinoma as a potent prognostic predictor associated with proliferation, migration and chemoresistance
Hiroyuki Minemura, Kiyoshi Takagi, et al.

Upregulation of programmed cell death ligand 1 promotes resistance response in non-small-cell lung cancer patients treated with neo-adjuvant chemotherapy
Panpan Zhang, Yuanyuan Ma, et al.

Expression of metastasis suppressor gene AES driven by a Yin Yang (YY) element in a CpG island promoter and transcription factor YY2
Fumihiko Kakizaki, Masahiro Sonoshita, et al.

Open access


Genetic alterations in adult T-cell leukemia/lymphoma
Yasunori Kogure and Keisuke Kataoka

Intersection of retinoblastoma tumor suppressor function, stem cells, metabolism, and inflammation
Shunsuke Kitajima and Chiaki Takahashi

DNA origami applications in cancer therapy
Anuttara Udomprasert and Thaned Kangsamaksin

Integrated functions of membrane-type 1 matrix metalloproteinase in regulating cancer malignancy: Beyond a proteinase
Takeharu Sakamoto and Motoharu Seiki

A vicious partnership between AKT and PHLDA3 to facilitate neuroendocrine tumors
Masahiro Takikawa and Rieko Ohki

Clinical development of anti-CD19 chimeric antigen receptor T-cell therapy for B-cell non-Hodgkin lymphoma
Shinichi Makita, Kiyoshi Yoshimura, et al.

Discovery of Mieap-regulated mitochondrial quality control as a new function of tumor suppressor p53
Yasuyuki Nakamura and Hirofumi Arakawa

Emergence of TNIK inhibitors in cancer therapeutics
Tesshi Yamada and Mari Masuda

Recent advances in genetic modification of adenovirus vectors for cancer treatment
Yuki Yamamoto, Masaki Nagasato, et al.

Oncogenic roles of SMARCB1/INI1 and its deficient tumors
Kenichi Kohashi and Yoshinao Oda

Epigenetics in normal and malignant hematopoiesis: An overview and update 2017
Susumu Goyama and Toshio Kitamura

Impact of senescence-associated secretory phenotype and its potential as a therapeutic target for senescence-associated diseases
Sugiko Watanabe, Shimpei Kawamoto, et al.

Molecular-targeting therapies against quantitative abnormalities in gene expression with malignant tumors
Toshiyuki Sakai and Yoshihiro Sowa

Tumor-derived spheroids: Relevance to cancer stem cells and clinical applications
Tatsuya Ishiguro, Hirokazu Ohata, et al.

Possible functions of CD169-positive sinus macrophages in lymph nodes in anti-tumor immune responses
Yoshihiro Komohara, Koji Ohnishi, et al.

Hepatocyte growth factor/MET in cancer progression and biomarker discovery
Kunio Matsumoto, Masataka Umitsu, et al.

Antizyme inhibitor 1: a potential carcinogenic molecule
Shiqiao Qiu, Jing Liu, et al.