Downregulation of TBXAS1 in an iron-induced malignant mesothelioma model
Daisuke Minami, Nagio Takigawa, Yuka Kato, Kenichiro Kudo, Hideko Isozaki, Shinsuke Hashida, Daijiro Harada, Nobuaki Ochi, Masanori Fujii, Toshio Kubo, Kadoaki Ohashi, Akiko Sato, Takehiro Tanaka, Katsuyuki Hotta, Masahiro Tabata, Shinichi Toyooka, Mitsune Tanimoto and Katsuyuki Kiura
Article first published online: 19 SEP 2015 | DOI: 10.1111/cas.12752
Evidence suggests that the major pathology associated with asbestos-induced mesothelioma is local iron overload. Here, we first confirmed the iron-induced mesothelioma rat model and then examined the entire rat genome using array-based comparative genomic hybridization (CGH). CGH identified a common chromosomal deletion mapped to the chromosomal 4q31 locus, which encompasses the TBXAS1 gene. Finally, we evaluated whether the results of the CGH analysis could be extrapolated to human mesothelioma cell lines and clinical samples.