Utility of KRAS mutation detection using circulating cell-free DNA from patients with colorectal cancer
Takeshi Yamada, Takuma Iwai, Goro Takahashi, Hayato Kan, Michihiro Koizumi, Akihisa Matsuda, Seiichi Shinji, Aya Yamagishi, Yasuyuki Yokoyama, Atsushi Tatsuguchi, Tatsuro Kawagoe, Shiro Kitano, Masato Nakayama, Satoshi Matsumoto and Eiji Uchida
Version of Record online: 13 JUN 2016 | DOI: 10.1111/cas.12959
We showed the usefulness of detecting KRAS mutations in cell-free DNA in patients with KRAS wild-type and mutated colorectal cancer using our new high-sensitivity method and digital PCR. It is as an attractive method for predicting patient prognosis, monitoring tumor progression, and predicting response to epidermal growth factor receptor (EGFR) blockade, allowing for more personalized patient care. Moreover, we showed the utility of detection of KRAS mutations in cell-free DNA as a biomarker for early detection of recurrence in patients with KRAS mutated tumors.