CMTM3 inhibits cell migration and invasion and correlates with favorable prognosis in gastric cancer
Yu Su, Yi Lin, Lianhai Zhang, Baocai Liu, Wanqiong Yuan, Xiaoning Mo, Xiaohong Wang, Henan Li, Xiaofang Xing, Xiaojing Cheng, Bin Dong, Ying Hu, Hong Du, Yubing Zhu, Ning Ding, Jiyou Li, Weili Liu, Yongzhen Ma, Xiaoyan Qiu, Jiafu Ji and Wenling Han
Article first published online: 28 NOV 2013 | DOI: 10.1111/cas.12304
CMTM3, a novel tumor suppressor gene, was silenced in several gastric cancer cell lines and dramatically downregulated in gastric cancer tissues. CMTM3 inhibited the migration and invasion of gastric cancer cells both in vitro and in vivo, and reduced MMP2 expression and ERK1/2 phosphorylation. More importantly, CMTM3 was associated with favourable prognosis in gastric cancer.