Duodenal follicular lymphoma: Comprehensive gene expression analysis with insights into pathogenesis
Katsuyoshi Takata, Motohiko Tanino, Daisuke Ennishi, Akira Tari, Yasuharu Sato, Hiroyuki Okada, Yoshinobu Maeda, Naoe Goto, Hiroshi Araki, Mai Harada, Midori Ando, Masaya Iwamuro, Mitsune Tanimoto, Kazuhide Yamamoto, Randy D. Gascoyne and Tadashi Yoshino
Article first published online: 6 APR 2014 | DOI: 10.1111/cas.12392
In the present study, we examined 10 DFL, 18 NFL, 10 gastric MALT lymphoma samples by gene expression analysis. Gene expression profiles of the 3 lymphoma types were compared using 2918 differentially expressed genes (DEGs) and results suggested that DFL shares characteristics of MALT lymphoma. Increased expression of CCL20 and MAdCAM-1 and co-expression of CCL20 and CCR6 may play an important role in tumorigenesis in DFL.