Cancer Science

Cover image for Vol. 105 Issue 12

Early View (Online Version of Record published before inclusion in an issue)

Edited By: Yusuke Nakamura

Impact Factor: 3.534

ISI Journal Citation Reports © Ranking: 2013: 68/203 (Oncology)

Online ISSN: 1349-7006

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  1. Original Articles

    1. You have full text access to this OnlineOpen article
      Therapeutic activity of glycoengineered anti-GM2 antibodies against malignant pleural mesothelioma

      Qi Li, Wei Wang, Yusuke Machino, Tadaaki Yamada, Kenji Kita, Masanobu Oshima, Yoshitaka Sekido, Mami Tsuchiya, Yui Suzuki, Ken-ichiro Nan-ya, Shigeru Iida, Kazuyasu Nakamura, Shotaro Iwakiri, Kazumi Itoi and Seiji Yano

      Article first published online: 18 DEC 2014 | DOI: 10.1111/cas.12575

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      In this study, the anti-GM2 antibody BIW-8962 first showed a significant ADCC activity against malignant pleural mesothelioma (MPM) cell line and therapeutic activity in an in vivo orthotropic mouse model using the cell line. Additionally, the GM2 expression was confirmed in the MPM clinical specimens. These data suggest that anti-GM2 antibodies may become a therapeutic option for MPM patients.

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      Inducing malignant transformation of endometriosis in rats by long-term sustaining hyperestrogenemia and type II diabetes

      Chang-Ting Wang, Dan-Bo Wang, Kui-Ran Liu, Yan Li, Chun-Xiao Sun, Cui-Shan Guo and Fang Ren

      Article first published online: 18 DEC 2014 | DOI: 10.1111/cas.12573

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      Hyperestrogenemia and type II diabetes could induce malignant transformation of endometriosis in SD rats. The eutopic endometrium and endometriosis showed similar responses and pathological changes to the carcinogenic simulations; however, endometriosis had higher susceptibility and risk for oncogenesis.

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      Heat shock protein 90 targets a chaperoned peptide to the static early endosome for efficient cross-presentation by human dendritic cells

      Tsutomu Tanaka, Koichi Okuya, Goro Kutomi, Akari Takaya, Toshimitsu Kajiwara, Takayuki Kanaseki, Tomohide Tsukahara, Yoshihiko Hirohashi, Toshihiko Torigoe, Koichi Hirata, Yoshiharu Okamoto, Noriyuki Sato and Yasuaki Tamura

      Article first published online: 15 DEC 2014 | DOI: 10.1111/cas.12570

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      An Hsp90-cancer antigen peptide complex was efficiently cross-presented by human monocyte-derived DCs and induced peptide-specific CTLs. The internalized Hsp90-peptide complex was strictly sorted to the Rab5+, EEA1+ static early endosome, where the Hsp90-chaperoned peptide was processed and bound to MHC class I molecules.

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      Microparticles induce multifactorial resistance through oncogenic pathways independently of cancer cell type

      Paloma Silva de Souza, André L.S. Cruz, João P.B. Viola and Raquel C. Maia

      Article first published online: 15 DEC 2014 | DOI: 10.1111/cas.12566

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      Microparticles promoted microRNA transfer and NFkB and Yb-1 oncogenic pathway activation. Microparticles can induce a multifactorial phenotype in sensitive cancer cells.

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      Intermittent chemotherapy can retain the therapeutic potential of anti-CD137 antibody during the late tumor-bearing state

      Miki Tongu, Nanae Harashima, Koji Tamada, Lieping Chen and Mamoru Harada

      Article first published online: 9 DEC 2014 | DOI: 10.1111/cas.12568

      Intermittent chemotherapy and anti-CD137 antibody therapy.

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      Methylation-induced downregulation of TFPI-2 causes TMPRSS4 overexpression and contributes to oncogenesis in a subset of non-small-cell lung carcinoma

      Junko Hamamoto, Kenzo Soejima, Katsuhiko Naoki, Hiroyuki Yasuda, Yuichiro Hayashi, Satoshi Yoda, Sohei Nakayama, Ryosuke Satomi, Hideki Terai, Shinnosuke Ikemura, Takashi Sato, Daisuke Arai, Kota Ishioka, Keiko Ohgino and Tomoko Betsuyaku

      Article first published online: 8 DEC 2014 | DOI: 10.1111/cas.12569

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      TMPRSS4 was up-regulated by silencing of TFPI-2 through aberrant DNA methylation and contributed to oncogenesis in NSCLC. It will provide novel therapeutic potential for NSCLC patients by suppressing TMPRSS4 through inhibiting TMPRSS4 directly or indirectly through demethylating TFPI-2.

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      ABCB1 polymorphism as prognostic factor in breast cancer patients treated with docetaxel and doxorubicin neoadjuvant chemotherapy

      Hee-Jun Kim, Seock-Ah Im, Bhumsuk Keam, Hye Seon Ham, Kyung Hun Lee, Tae Yong Kim, Yu Jung Kim, Do-Youn Oh, Jee Hyun Kim, Wonshik Han, In-Jin Jang, Tae-You Kim, In Ae Park and Dong Young Noh

      Article first published online: 8 DEC 2014 | DOI: 10.1111/cas.12560

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      ABCB1 encodes P-glycoproteins (P-gp), a membrane-bound efflux pump, which has been shown to remove chemotherapeutic drugs including docetaxel and doxorubicin from the cells. In this prospective observational study, ABCB1 C3435T polymorphism was significantly associated with improved survival as well as increased frequency of toxicity after neoadjuvant combination chemotherapy of docetaxel and doxorubicin in Asian patients with stage II or III breast cancer. This study results provides valuable information on individualized therapy in selecting optimal patients and drugs according to genotypes.

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      High-dose chemotherapeutics of intravesical chemotherapy rapidly induce mitochondrial dysfunction in bladder cancer-derived spheroids

      Takahiro Yoshida, Hiroaki Okuyama, Masashi Nakayama, Hiroko Endo, Norio Nonomura, Kazuo Nishimura and Masahiro Inoue

      Article first published online: 8 DEC 2014 | DOI: 10.1111/cas.12567

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      High-dose chemotherapeutics induce necrosis-like death with round nuclei in contrast to typical apoptosis characterized by DNA fragmentation caused by low-dose chemotherapeutics in bladder cancer-derived spheroids.

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      Immunological significance of the accumulation of autophagy components in oral squamous cell carcinoma

      Koichi Sakakura, Hideyuki Takahashi, Kyoichi Kaira, Minoru Toyoda, Tetsunari Oyama and Kazuaki Chikamatsu

      Article first published online: 8 DEC 2014 | DOI: 10.1111/cas.12559

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      This work describes the correlation between the expression of autophagy-related proteins and infiltration of immune cells in tumour microenvironment. The correlation observed between LC3 or p62/SQSTM1 and the infiltration of T cells suggests that autophagy may actively mobilise immune cells toward the cancer bed. Meanwhile, the three autophagy-associated proteins examined were linked to the malignant potential and an unfavorable prognosis.

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      Prognostic significance of promyelocytic leukemia expression in gastrointestinal stromal tumor; integrated proteomic and transcriptomic analysis

      Hiroshi Ichikawa, Akihiko Yoshida, Tatsuo Kanda, Shin-ichi Kosugi, Takashi Ishikawa, Takaaki Hanyu, Takahiro Taguchi, Marimu Sakumoto, Hitoshi Katai, Akira Kawai, Toshifumi Wakai and Tadashi Kondo

      Article first published online: 4 DEC 2014 | DOI: 10.1111/cas.12565

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      GISTs of the small intestine shows more aggressive behavior than those of the stomach. Integrated proteomic and transcriptomic analysis identified PML, a tumor suppressor gene, was down-regulated in GISTs of the small intestine. Immunohistochemical study revealed the prognostic utility of PML in the cases of GIST from multiple clinical facilities.

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      Determinants of participation in prostate cancer screening: A simple analytical framework to account for healthy-user bias

      Takahiro Tabuchi, Tomio Nakayama, Wakaba Fukushima, Ichiro Matsunaga, Satoko Ohfuji, Kyoko Kondo, Eiji Kawano, Hiroyuki Fukuhara, Yuri Ito and Akira Oshima

      Article first published online: 3 DEC 2014 | DOI: 10.1111/cas.12561

      This is the first study to explore determinants of PSA-screening participation while simultaneously taking into account factors associated with FOBT, and propose a simple analytical framework for “among-responders analysis.” This approach may provide a more sophisticated interpretation of participation in various screenings with different levels of recommendation.

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      Phloroglucinol suppresses metastatic ability of breast cancer cells by inhibition of epithelial-mesenchymal cell transition

      Rae-Kwon Kim, Yongjoon Suh, Ki-Chun Yoo, Yan-Hong Cui, Eunji Hwang, Hyun-Jin Kim, Ju-Seop Kang, Min-Jung Kim, Young Yiul Lee and Su-Jae Lee

      Article first published online: 3 DEC 2014 | DOI: 10.1111/cas.12562

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      Phloroglucinol, a natural phlorotannin component of brown algae has an anticancer activity against metastasis of breast cancer cells to lungs. Phloroglucinol decreases EMT master regulator SLUG through inhibition of PI3K/AKT and RAS/RAF-1/ERK signaling.

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      Estrogen adversely affects the prognosis of patients with lung adenocarcinoma

      Li-Han Hsu, Ko-Jiunn Liu, Ming-Fang Tsai, Chang-Ru Wu, An-Chen Feng, Nei-Min Chu and Shu-Huei Kao

      Article first published online: 28 NOV 2014 | DOI: 10.1111/cas.12558

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      Estrogen up-regulates osteopontin expression and promotes lung cancer cell migration via the MEK/ERK signaling pathway. Osteopontin contributes to the cross-talk between estrogen receptor and epidermal growth factor receptor signaling pathways.

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