Cancer Science

Cover image for Vol. 105 Issue 4

Early View (Online Version of Record published before inclusion in an issue)

Edited By: Yusuke Nakamura

Impact Factor: 3.479

ISI Journal Citation Reports © Ranking: 2012: 69/197 (Oncology)

Online ISSN: 1349-7006

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  1. 1 - 16
  1. Original Articles

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      Inhibitors of differentiation-1 promotes nitrosopyrrolidine-induced transformation of HPV 16-immortalized cervical epithelial cell

      Lingxia Xie, Jinke Li, Yi Zhang, Bao Liu, Xue Peng, Yong Lin, Wenming Xu and Lina Hu

      Article first published online: 15 APR 2014 | DOI: 10.1111/cas.12398

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      Our study suggests that Id-1 promotes cervical epithelial transformation, which sheds lights on cervical cancer development and implies Id-1 as a potential target for cervical cancer prevention and therapy.

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      Genetic variants at 8q24 are associated with risk of esophageal squamous cell carcinoma in a Chinese population

      Ningbin Dai, Mingfeng Zheng, Cheng Wang, Yong Ji, Jiangbo Du, Chen Zhu, Yisha He, Meng Zhu, Xun Zhu, Min Sun, Juncheng Dai, Hongxia Ma, Jingyu Chen, Zhibin Hu, Haiyong Gu, Guangfu Jin and Hongbing Shen

      Article first published online: 13 APR 2014 | DOI: 10.1111/cas.12399

      We evaluated the relationship of gastric cancer (GC) risk-related variants at 1q22, 3q13.3, 5p13.1 and 8q24 with the risk of esophageal squamous cell carcinoma (ESCC) in a Chinese population with 2139 cases and 2273 controls. We found the T allele of rs2294008, an intronic variant of PSCA at 8q24 that was associated with an increased risk of GC, was inversely associated with a decreased risk of ESCC (OR = 0.90, 95 %CI: 0.81–0.99, P = 0.034).

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      Quercetin enhances apoptotic effect of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in ovarian cancer cells through reactive oxygen species (ROS) mediated CCAAT enhancer-binding protein homologous protein (CHOP)-death receptor 5 pathway

      Liu Yi, Yang Zongyuan, Gong Cheng, Zhang Lingyun, Yu GuiLian and Gong Wei

      Article first published online: 11 APR 2014 | DOI: 10.1111/cas.12395

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      Mitochondrial proteins (ROS) are mediating the apoptotic process, downstream or in parallel, CHOP might be a crucial player for DR5 upregulation and cancer cell killing by quercetin. IRE1a-JNK signaling could also be considered to be the major ER-stress pathway for quercetin induced CHOP expression, thus contributing to the enhanced apoptotic death of ovarian cancer cells to TRAIL. Quercetin could be an attractive candidate for combined chemotherapy against cancer.

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      Gene expression profiling of Epstein–Barr virus-positive diffuse large B-cell lymphoma of the elderly reveals alterations of characteristic oncogenetic pathways

      Harumi Kato, Kennosuke Karube, Kazuhito Yamamoto, Jun Takizawa, Shinobu Tsuzuki, Yasushi Yatabe, Teru Kanda, Miyuki Katayama, Yukiyasu Ozawa, Kenji Ishitsuka, Masataka Okamoto, Tomohiro Kinoshita, Koichi Ohshima, Shigeo Nakamura, Yasuo Morishima and Masao Seto

      Article first published online: 9 APR 2014 | DOI: 10.1111/cas.12389

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      EBV-positive diffuse large B-cell lymphoma (DLBCL) of the elderly is newly classified as a subtype of DLBCL in the 4th WHO classification. Comprehensive genetic analysis has not been investigaed. We identified the activation of JAK-STAT and NF-κB pathways was characteristic of the disease.

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      An inhibition of p62/SQSTM1 caused autophagic cell death of several human carcinoma cells

      Kaito Nihira, Yasuhiro Miki, Katsuhiko Ono, Takashi Suzuki and Hironobu Sasano

      Article first published online: 9 APR 2014 | DOI: 10.1111/cas.12396

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      p62/SQSTM1 (p62) is a multifunctional protein implicated in several signal transduction pathways and selectively degraded by autophagy, a process for lysosomal degradation of protein and organelle. Results of our present study revealed that p62-silencing resulted in the formation of mis-regulated multilayer autophagosomes and an autophagic cell death, and p62 can therefore be an attractive target for the development of anti-neoplastic agents.

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      Suppression of REV7 enhances cisplatin sensitivity in ovarian clear cell carcinoma cells

      Kaoru Niimi, Yoshiki Murakumo, Naoki Watanabe, Takuya Kato, Shinji Mii, Atsushi Enomoto, Masato Asai, Naoya Asai, Eiko Yamamoto, Hiroaki Kajiyama, Kiyosumi Shibata, Fumitaka Kikkawa and Masahide Takahashi

      Article first published online: 7 APR 2014 | DOI: 10.1111/cas.12390

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      Immunohistochemical analysis of 137 epithelial ovarian cancer specimens revealed that high levels of REV7 expression were detected in clear cell carcinomas (CCC), and were associated with poor prognosis of advanced epithelial ovarian cancer. REV7 depletion in CCC cells enhanced sensitivity to cisplatin in vitro and in vivo, suggesting that REV7 could be a molecular target for CCC therapy.

  2. In This Issue

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      In This Issue

      Article first published online: 7 APR 2014 | DOI: 10.1111/cas.12402

  3. Original Articles

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      Duodenal follicular lymphoma: Comprehensive gene expression analysis with insights into pathogenesis

      Katsuyoshi Takata, Motohiko Tanino, Daisuke Ennishi, Akira Tari, Yasuharu Sato, Hiroyuki Okada, Yoshinobu Maeda, Naoe Goto, Hiroshi Araki, Mai Harada, Midori Ando, Masaya Iwamuro, Mitsune Tanimoto, Kazuhide Yamamoto, Randy D. Gascoyne and Tadashi Yoshino

      Article first published online: 6 APR 2014 | DOI: 10.1111/cas.12392

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      In the present study, we examined 10 DFL, 18 NFL, 10 gastric MALT lymphoma samples by gene expression analysis. Gene expression profiles of the 3 lymphoma types were compared using 2918 differentially expressed genes (DEGs) and results suggested that DFL shares characteristics of MALT lymphoma. Increased expression of CCL20 and MAdCAM-1 and co-expression of CCL20 and CCR6 may play an important role in tumorigenesis in DFL.

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      Diagnostic approach for cancer cells in urine sediments by 5-aminolevulinic acid-based photodynamic detection in bladder cancer

      Makito Miyake, Yasushi Nakai, Satoshi Anai, Yoshihiro Tatsumi, Masaomi Kuwada, Sayuri Onishi, Yoshitomo Chihara, Nobumichi Tanaka, Yoshihiko Hirao and Kiyohide Fujimoto

      Article first published online: 6 APR 2014 | DOI: 10.1111/cas.12393

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      The ALA-based fluorescence detection assays detected bladder cancer cells in urine sediments of low-grade and low-stage bladder urothelial cells at higher rate than conventional urine markers. The ALA-based assay are promising tool for the management of bladder cancer.

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      Bone resorption facilitates osteoblastic bone metastatic colonization by cooperation of insulin-like growth factor and hypoxia

      Takahiro Kuchimaru, Takuya Hoshino, Tomoya Aikawa, Hisataka Yasuda, Tatsuya Kobayashi, Tetsuya Kadonosono and Shinae Kizaka-Kondoh

      Article first published online: 3 APR 2014 | DOI: 10.1111/cas.12391

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      Bone resorption facilitates cancer cell colonization of osteoblastic bone metastasis. We revealed that insulin-like growth factor-1 released from the bone during bone resorption and hypoxia-inducible factor activity cooperatively promote cancer cell colonization in hypoxic bone marrow.

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      High-resolution genomic copy number profiling of primary intraocular lymphoma by single nucleotide polymorphism microarrays

      Ludan Wang, Aiko Sato-Otsubo, Sunao Sugita, Hiroshi Takase, Manabu Mochizuki, Yoshihiko Usui, Hiroshi Goto, Takatoshi Koyama, Hiroki Akiyama, Osamu Miura, Seishi Ogawa and Ayako Arai

      Article first published online: 1 APR 2014 | DOI: 10.1111/cas.12388

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      The genetic features of primary intraocular lymphoma (PIOL) have not yet been elucidated. We carried out single nucleotide polymorphism array karyotyping of IOL using genomic DNA extracted from vitreous fluid. Recurrent copy number gain regions in PIOLs were detected most frequently on chromosome 1q followed by 18q and 19q. There was a correlation between gain of the IL-10 gene located on 1q and intravitreal interleukin-10 concentration, which was higher in IOL than in benign uveitis.

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      Inhibition of histone methyltransferase EZH2 depletes leukemia stem cell of mixed lineage leukemia fusion leukemia through upregulation of p16

      Koki Ueda, Akihide Yoshimi, Yuki Kagoya, Satoshi Nishikawa, Victor E. Marquez, Masahiro Nakagawa and Mineo Kurokawa

      Article first published online: 30 MAR 2014 | DOI: 10.1111/cas.12386

      Leukemia stem cells (LSCs) are main cause of relapse or refractoriness to conventional chemotherapy. Although eradicating LSCs are ideal goal for anti-leukemia therapy, drugs targeting LSCs have scarcely been identified. Polycomb group proteins are associated with controlling stemness including activity of cancer stem cells, and can be pharmacologically targeted by a selective inhibitor of H3K27, DZNep. To our surprise, EZH2 inhibition by DZNep or shRNA not only suppressed MLL fusion leukemia proliferation but also reduced LSCs frequency. Dysregulation of p16 is supposed to be responsible for the effect. We also show that EZH2 are highly enriched around the transcription-start-site of p16, together with H3K27 methylation marks in MLL/ENL cells. Although high expression of Hoxa9 in MLL fusion leukemia is supposed to be responsible for the recruitment of EZH2, our data also suggests that there may be some other mechanisms independent of Hoxa9 activation to suppress p16 expression. We believe that these findings would help us to develop LICs targeted therapy for MLL fusion leukemia.

  4. Review Articles

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      Not just gRASping at flaws: Finding vulnerabilities to develop novel therapies for treating KRAS mutant cancers

      Hiromichi Ebi, Anthony C. Faber, Jeffrey A. Engelman and Seiji Yano

      Article first published online: 26 MAR 2014 | DOI: 10.1111/cas.12383

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      Mutations in Kirsten rat-sarcoma (KRAS) are well appreciated to be major contributors of human cancers through dysregulation of multiple growth and survival pathways. The main effector pathways of KRAS and current approaches to develop combination therapies targeting these KRAS-effector pathways are discussed. Also, other approaches targeting KRAS, including synthetic lethal screening are summarized.

  5. Original Articles

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      Incidence and prediction of invasive disease and nodal metastasis in preoperatively diagnosed ductal carcinoma in situ

      Tomo Osako, Takuji Iwase, Masaru Ushijima, Rie Horii, Yasuyoshi Fukami, Kiyomi Kimura, Masaaki Matsuura and Futoshi Akiyama

      Article first published online: 26 MAR 2014 | DOI: 10.1111/cas.12381

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      Most patients with a preoperative diagnosis of ductal carcinoma in situ of the breast had no metastasis or only micrometastasis in axillary nodes, even though invasive disease was found on final pathology. Predictors of the invasive disease were not completely consistent with those of nodal metastasis. Therefore, the selective application of sentinel node biopsy in patients with a higher risk of invasive disease may not accurately identify the patients with a higher likelihood of sentinel node metastasis.

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      Saracatinib impairs the peritoneal dissemination of diffuse-type gastric carcinoma cells resistant to Met and fibroblast growth factor receptor inhibitors

      Hideki Yamaguchi, Miho Takanashi, Nachi Yoshida, Yuumi Ito, Reiko Kamata, Kiyoko Fukami, Kazuyoshi Yanagihara and Ryuichi Sakai

      Article first published online: 24 MAR 2014 | DOI: 10.1111/cas.12387

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      Saracatinib impaired peritoneal dissemination of 44As3Luc scirrhous gastric carcinoma cells that are resistant to Met and FGFR inhibition.

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      GATA4 immunolocalization in breast carcinoma as a potent prognostic predictor

      Kiyoshi Takagi, Takashi Moriguchi, Yasuhiro Miki, Yasuhiro Nakamura, Mika Watanabe, Takanori Ishida, Masayuki Yamamoto, Hironobu Sasano and Takashi Suzuki

      Article first published online: 19 MAR 2014 | DOI: 10.1111/cas.12382

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      In this study, we explored the possible roles of GATA4 in human breast cancer. GATA4 immunoreactivity was positively associated with distant metastasis, and outcome analyses revealed that GATA4 immunoreactivity was associated with shorter disease-free and breast cancer-specific survival of the patients. These data may suggest important roles of GATA4 in the process of breast cancer progression.

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