Cancer Science

Cover image for Vol. 107 Issue 5

Early View (Online Version of Record published before inclusion in an issue)

Edited By: Yusuke Nakamura

Impact Factor: 3.523

ISI Journal Citation Reports © Ranking: 2014: 73/211 (Oncology)

Online ISSN: 1349-7006

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  1. 1 - 18
  1. Review Articles

    1. You have full text access to this OnlineOpen article
      Gene aberrations for precision medicine against lung adenocarcinoma

      Motonobu Saito, Kouya Shiraishi, Hideo Kunitoh, Seiichi Takenoshita, Jun Yokota and Takashi Kohno

      Version of Record online: 25 MAY 2016 | DOI: 10.1111/cas.12941

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      In this review, we summarized the gene aberrations that underlie carcinogenesis and guide personalized therapy against LADC.

  2. Original Articles

    1. You have full text access to this OnlineOpen article
      Linkage of E2F1 transcriptional network and cell proliferation with respiratory chain activity in breast cancer cells

      Kazunori Mori, Tetsu Uchida, Motonori Fukumura, Shigetoshi Tamiya, Masato Higurashi, Hirosato Sakai, Fumihiro Ishikawa and Motoko Shibanuma

      Version of Record online: 20 MAY 2016 | DOI: 10.1111/cas.12953

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      A novel coupling between ETC activity and the core regulatory machinery for cell cycle progression.

    2. You have full text access to this OnlineOpen article
      Metabonomic changes from pancreatic intraepithelial neoplasia to pancreatic ductal adenocarcinoma in tissues from rats

      Shi Wen, Zhishui Li, Jianghua Feng, Jianxi Bai, Xianchao Lin and Heguang Huang

      Version of Record online: 17 MAY 2016 | DOI: 10.1111/cas.12939

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      The metabonomic alterations in pancreatic intraepithelial neoplasia and pancreatic ductal adenocarcinoma in SD rats were analysed with NMR-based metabonomic method.The differences in metabonomics and corresponding signatures were discovered to be beneficial for better understanding of pathophysiological mechanism and early diagnosis of PDAC.

    3. You have full text access to this OnlineOpen article
      Negative influence of programmed death-1-ligands on the survival of esophageal cancer patients treated with chemotherapy

      Koji Tanaka, Hiroshi Miyata, Keijiro Sugimura, Takashi Kanemura, Mika Hamada-Uematsu, Yu Mizote, Makoto Yamasaki, Hisashi Wada, Kiyokazu Nakajima, Shuji Takiguchi, Masaki Mori, Yuichiro Doki and Hideaki Tahara

      Version of Record online: 16 MAY 2016 | DOI: 10.1111/cas.12938

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      In this study, we examined the expression of programmed death-1ligands (PD-Ls; PD-L1 and PD-L2), which may play important roles in immunological tumor evasion, in esophageal cancer tissue obtained from patients with or without preoperative chemotherapy. The results showed significant involvement of PD-1/PD-Ls mechanism in the survival after the chemotherapy. Our findings provide the rationale of combination of conventional chemotherapy and blockade of immunological tumor evasion system such as PD-1/PD-Ls pathway and could lead to the logical development of novel treatments for esophageal cancer.

    4. You have full text access to this OnlineOpen article
      Novel p53 target gene FUCA1 encodes a fucosidase and regulates growth and survival of cancer cells

      Issei Ezawa, Yuichiro Sawai, Tatsuya Kawase, Atsushi Okabe, Shuichi Tsutsumi, Hitoshi Ichikawa, Yuka Kobayashi, Fumio Tashiro, Hideo Namiki, Tadashi Kondo, Kentaro Semba, Hiroyuki Aburatani, Yoichi Taya, Hitoshi Nakagama and Rieko Ohki

      Version of Record online: 16 MAY 2016 | DOI: 10.1111/cas.12933

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      We show that a p53 target gene, FUCA1, encodes a fucosidase and has a tumor suppressive function. Expression of FUCA1 suppressed the growth of cancer cells and induced cell death in a manner dependent on its enzymatic activity. Furthermore, we showed that expression of FUCA1 reduced the fucosylation and activation of EGFR, and concomitantly suppressed downstream EGF signaling pathways. In addition, we found that loss-of-function mutations in FUCA1 occur in some cancers, as well as reduced expression. Low FUCA1 expression is also associated with poorer prognosis in cancer patients. These results collectively suggest that defucosylation by FUCA1 contributes to tumor suppression, and thus identifies a novel mechanism of tumor suppression that involves FUCA1-mediated protein defucosylation.

    5. You have full text access to this OnlineOpen article
      Phase II trial of neoadjuvant chemotherapy with docetaxel, nedaplatin, and S1 for advanced esophageal squamous cell carcinoma

      Yoshihiro Tanaka, Kazuhiro Yoshida, Toshiyuki Tanahashi, Naoki Okumura, Nobuhisa Matsuhashi and Kazuya Yamaguchi

      Version of Record online: 12 MAY 2016 | DOI: 10.1111/cas.12943

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      This DGS regimen was well tolerated and highly active.

    6. You have full text access to this OnlineOpen article
      Identification of anti-cancer chemical compounds using Xenopus embryos

      Masamitsu Tanaka, Sei Kuriyama, Go Itoh, Aki Kohyama, Yoshiharu Iwabuchi, Hiroyuki Shibata, Masakazu Yashiro and Namiko Aiba

      Version of Record online: 12 MAY 2016 | DOI: 10.1111/cas.12940

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      Cancer tissues have biological characteristics similar to those observed in embryos during development. A novel chemical-screening approach based on Xenopus embryos in this study is an effective method for isolating anti-cancer drugs especially targeting cancer cell invasion and proliferation.

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      Validation of chemical compound library screening for transcriptional co-activator with PDZ-binding motif inhibitors using GFP-fused transcriptional co-activator with PDZ-binding motif

      Shunta Nagashima, Junichi Maruyama, Shodai Kawano, Hiroaki Iwasa, Kentaro Nakagawa, Mari Ishigami-Yuasa, Hiroyuki Kagechika, Hiroshi Nishina and Yutaka Hata

      Version of Record online: 12 MAY 2016 | DOI: 10.1111/cas.12936

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      Transcriptional co-activator with PDZ-binding motif (TAZ) regulates cell proliferation and differentiation. Hyperactive TAZ confers malignant properties to cancer cells and worsens the clinical prognosis. Thus the development of TAZ inhibitors is important in the cancer therapy. We generated a cell-based assay to search for TAZ inhibitors and evaluated the validity and the limitation of the assay.

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      Phase I study of palbociclib, a cyclin-dependent kinase 4/6 inhibitor, in Japanese patients

      Kenji Tamura, Hirofumi Mukai, Yoichi Naito, Kan Yonemori, Makoto Kodaira, Yuko Tanabe, Noboru Yamamoto, Shozo Osera, Masaoki Sasaki, Yuko Mori, Satoshi Hashigaki, Takashi Nagasawa, Yoshiko Umeyama and Takayuki Yoshino

      Version of Record online: 11 MAY 2016 | DOI: 10.1111/cas.12932

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      This phase 1 study in Japanese patients evaluates the safety, pharmacokinetics, and preliminary efficacy of palbociclib as monotherapy for solid tumors (part 1) and combined with letrozole as first-line treatment of postmenopausal patients with ER+/HER2− advanced breast cancer (part 2). Overall, the results of this study suggest that palbociclib 125 mg was tolerated and is a recommended dose for monotherapy and letrozole combination therapy in Japanese patients.

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      MYC translocation and/or BCL 2 protein expression are associated with poor prognosis in diffuse large B-cell lymphoma

      Keisuke Kawamoto, Hiroaki Miyoshi, Noriaki Yoshida, Naoya Nakamura, Koichi Ohshima, Hirohito Sone and Jun Takizawa

      Version of Record online: 6 MAY 2016 | DOI: 10.1111/cas.12942

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      In this study, we examined the relationships between genomic alterations and protein expression of MYC, BCL2, and BCL6 in diffuse large B-cell lymphoma. Although the clinical utility of protein expression and translocation of MYC and BCL2 is controversial in diffuse large B-cell lymphoma, we confirmed that MYC translocation, as detected by fluorescence in situ hybridization, and BCL2 expression, as analyzed by immunohistochemistry, were important for predicting survival.

    10. You have full text access to this OnlineOpen article
      Cisplatin treatment increases stemness through upregulation of hypoxia-inducible factors by interleukin-6 in non-small cell lung cancer

      Fuquan Zhang, Shanzhou Duan, Ying Tsai, Peter C. Keng, Yongbing Chen, Soo Ok Lee and Yuhchyau Chen

      Version of Record online: 3 MAY 2016 | DOI: 10.1111/cas.12937

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      IL-6 mediated-hypoxia inducible factor up-regulation is important in increasing cancer stem cell numbers during cisplatin-resistance development. We suggest that the strategies of inhibiting IL-6 signaling or its downstream hypoxia inducible factor molecules can be used as future therapeutic approaches to block the cancer stem cell increase after cisplatin treatment in lung cancer.

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      Prognostic significance of CD169-positive lymph node sinus macrophages in patients with endometrial carcinoma

      Koji Ohnishi, Munekage Yamaguchi, Chimeddulam Erdenebaatar, Fumitaka Saito, Hironori Tashiro, Hidetaka Katabuchi, Motohiro Takeya and Yoshihiro Komohara

      Version of Record online: 3 MAY 2016 | DOI: 10.1111/cas.12929

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      We have demonstrated the prognostic significance of CD169+ sinus macrophages in the RLNs of patients with EC. A greater number of CD169+ macrophages and an increased ratio of CD169+-to-CD68+ macrophages in the RLNs were significantly associated with a better clinical prognosis. CD169+ sinus macrophages found in RLNs may therefore be involved in cytotoxic T-cell- and NK cell-mediated antitumor immunity. Evaluation of CD169 protein expression in RLNs may aid estimations of clinical prognoses and improve the monitoring of anti-tumor immune responses in patients with EC.

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      Identification of ganglioside GM2 activator playing a role in cancer cell migration through proteomic analysis of breast cancer secretomes

      Jihye Shin, Gamin Kim, Jong Won Lee, Ji Eun Lee, Yoo Seok Kim, Jong-Han Yu, Seung-Taek Lee, Sei Hyun Ahn, Hoguen Kim and Cheolju Lee

      Version of Record online: 27 APR 2016 | DOI: 10.1111/cas.12935

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      Our integrated approach using the secretome analysis for BC cancer cells and publicly available datasets, allowed selection of candidate biomarkers of BC. Of the 12 candidate biomarkers of BC, we were able to show that GM2A plays a key role in migration of BC cells in the current study. Although, Western blot and ELISA data do not provide strong evidence that GM2A is useful as a screening marker for BC, we were able to find that both specificity and sensitivity of GM2A were increased for ER negative patients in comparison with ER positive patients.

    13. You have full text access to this OnlineOpen article
      Y-632 inhibits heat shock protein 90 (Hsp90) function by disrupting the interaction between Hsp90 and Hsp70/Hsp90 organizing protein, and exerts antitumor activity in vitro and in vivo

      Wenqian Wang, Yang Liu, Zhixin Zhao, Chengying Xie, Yongping Xu, Youhong Hu, Haitian Quan and Liguang Lou

      Version of Record online: 27 APR 2016 | DOI: 10.1111/cas.12934

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      Y -632 is a promising Hsp90 inhibitor with novel mechanisms. Y -632 inhibits Hsp90 through disrupting Hsp90-Hop interaction. Hsp90-Hop interaction disruption results from Y -632 induced thiol oxidation.

    14. You have full text access to this OnlineOpen article
      TP53 mutation at early stage of colorectal cancer progression from two types of laterally spreading tumors

      Eiji Sakai, Masaki Fukuyo, Keisuke Matsusaka, Ken Ohata, Noriteru Doi, Kiyoko Takane, Nobuyuki Matsuhashi, Junichi Fukushima, Atsushi Nakajima and Atsushi Kaneda

      Version of Record online: 27 APR 2016 | DOI: 10.1111/cas.12930

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      We conducted targeted exon sequencing study of flat, early colorectal lesions, so-called laterally spreading tumors (LSTs), to gain insight into involvement of molecular alterations in progression of colorectal cancer through de novo pathway. APC mutation was frequently involved by adenoma stages in both granular-type LST (LST-G) and non-granular LST (LST-NG), suggesting its involvement in tumor initiation in LSTs. TP53 mutation was involved during cancer development from adenoma to cancer for both LST-G and LST-NG, but was involved at earlier stage in LST-NG.

    15. You have full text access to this OnlineOpen article
      Clinical prognostic value of DNA methylation in hepatoblastoma: Four novel tumor suppressor candidates

      Shohei Honda, Masashi Minato, Hiromu Suzuki, Masato Fujiyoshi, Hisayuki Miyagi, Masayuki Haruta, Yasuhiko Kaneko, Kanako C. Hatanaka, Eiso Hiyama, Takehiko Kamijo, Tadao Okada and Akinobu Taketomi

      Version of Record online: 27 APR 2016 | DOI: 10.1111/cas.12928

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      Using genome-wide methylation analysis and bisulfite pyrosequencing with specimens from hepatoblastoma tumors, GPR180, MST1R, OCIAD2 and PARP6 were identified as novel tumor suppressor candidates. The methylation status of those genes was significantly associated with a poor prognosis, age at diagnosis and the presence of metastatic tumors in 74 hepatoblastoma cases.

  3. Review Articles

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      Genetic abnormalities associated with acute lymphoblastic leukemia

      Takafumi Yokota and Yuzuru Kanakura

      Version of Record online: 27 APR 2016 | DOI: 10.1111/cas.12927

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      Recent technical advances in next-generation sequencing have shed light on genetic abnormalities in hematopoietic stem/progenitor cells as the precursor to pathogenesis of acute lymphoblastic leukemia. These findings are directly relevant to clinical hematology, and could contribute to accurate diagnosis, effective monitoring of residual disease, and patient-oriented therapies.

  4. Original Articles

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      Enhanced efficacy against cervical carcinomas through polymeric micelles physically incorporating the proteasome inhibitor MG132

      Yoko Matsumoto, Yuichiro Miyamoto, Horacio Cabral, Yu Matsumoto, Kazunori Nagasaka, Shunsuke Nakagawa, Tetsu Yano, Daichi Maeda, Katsutoshi Oda, Kei Kawana, Nobuhiro Nishiyama, Kazunori Kataoka and Tomoyuki Fujii

      Version of Record online: 27 APR 2016 | DOI: 10.1111/cas.12926

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      We focused on the ubiquitin proteasome inhibitor MG132 as the anticancer agent against cervical cancer cells, and physically incorporated it into micellar nanomedicines for achieving selective delivery to solid tumors and improving its in vivo efficacy. These MG132-loaded polymeric micelles (MG132/m) showed strong tumor inhibitory in vivo effect against HPV-positive tumors from HeLa and CaSki cells, and even in HPV-negative tumors from C33A cells.

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