XRCC3 is a promising target to improve the radiotherapy effect of esophageal squamous cell carcinoma
Jingjing Cheng, Weiran Liu, Xianliang Zeng, Bin Zhang, Yihang Guo, Minghan Qiu, Chao Jiang, Huanhuan Wang, Zhiqiang Wu, Maobin Meng, Hongqing Zhuang, Lujun Zhao, Jihui Hao, Qingqing Cai, Dan Xie, Qingsong Pang, Ping Wang, Zhiyong Yuan and Dong Qian
Article first published online: 6 NOV 2015 | DOI: 10.1111/cas.12820
Our data suggest that XRCC3 protects ESCC cells from ionizing radiation -induced death by promoting DNA damage repair and/or enhancing telomere stability. XRCC3 may be a novel radiosensitivity predictor and promising therapeutic target for ESCC.