Cancer Science

Cover image for Vol. 105 Issue 7

Early View (Online Version of Record published before inclusion in an issue)

Edited By: Yusuke Nakamura

Impact Factor: 3.479

ISI Journal Citation Reports © Ranking: 2012: 69/197 (Oncology)

Online ISSN: 1349-7006

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  1. Original Articles

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      Transforming growth factor-β-induced lncRNA-Smad7 inhibits apoptosis of mouse breast cancer JygMC(A) cells

      Mayu Arase, Kana Horiguchi, Shogo Ehata, Masato Morikawa, Shuichi Tsutsumi, Hiroyuki Aburatani, Kohei Miyazono and Daizo Koinuma

      Article first published online: 25 JUL 2014 | DOI: 10.1111/cas.12454

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      A long non-coding RNA, termed lncRNA-Smad7, was identified as a target of TGF-β in mouse mammary gland epithelial cell and breast cancer cells. lncRNA-Smad7 had anti-apoptotic functions downstream of TGF-β without altering the process of TGF-β-induced epithelial–mesenchymal transition, phosphorylation of Smad2, or expression of the Smad7 gene.

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      Significance of c-MET overexpression in cytotoxic anticancer drug-resistant small-cell lung cancer cells

      Hiroaki Ozasa, Tetsuya Oguri, Ken Maeno, Osamu Takakuwa, Eiji Kunii, Yoshitaka Yagi, Takehiro Uemura, Daishi Kasai, Mikinori Miyazaki and Akio Niimi

      Article first published online: 25 JUL 2014 | DOI: 10.1111/cas.12447

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      Activation of c-MET signaling pathway through an increase in the number of c-MET gene loci is one of novel mechanisms contributing to acquired resistance to cytotoxic anticancer drugs. c-MET inhibitor may overcome the rapid development of drug resistance, which results in the poor prognosis of lung cancer patients.

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      Phase II study of zoledronic acid combined with docetaxel for non-small-cell lung cancer: West Japan Oncology Group

      Haruyasu Murakami, Takeharu Yamanaka, Takashi Seto, Kenji Sugio, Isamu Okamoto, Toshiyuki Sawa, Tomonori Hirashima, Koji Takeda, Shinji Atagi, Masahiro Fukuoka, Yoichi Nakanishi, Kazuhiko Nakagawa and Nobuyuki Yamamoto

      Article first published online: 12 JUL 2014 | DOI: 10.1111/cas.12448

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      A randomized phase II study was evaluate the efficacy and safety of zoledronic acid in combination with docetaxel in previously treated patients with non-small cell lung cancer (NSCLC) and bone metastases. This study demonstrated the safety and tolerability of the combination of zoledronic acid and docetaxel but did not meet the primary endpoint of PFS in advanced NSCLC patients with bone metastasis.

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      Newly defined aberrant crypt foci as a marker for dysplasia in the rat colon

      Masako Ochiai, Yoshitaka Hippo, Masashi Izumiya, Masatoshi Watanabe and Hitoshi Nakagama

      Article first published online: 12 JUL 2014 | DOI: 10.1111/cas.12446

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      This study provides a simple methodology for accurate detection of dysplasia by a novel type of aberrant crypt foci, directly on the whole colon without histological examination. The newly defined lesion proved superior to all the previously described pre-malignant lesions, in terms of sensitivity and specificity for dysplasia, and simplicity in detection and diagnosis, which will likely pave the way for more detailed analysis of early stages of intestinal tumor development.

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      Indoleamine 2,3-dioxygenase promotes peritoneal metastasis of ovarian cancer by inducing an immunosuppressive environment

      Yuko Tanizaki, Aya Kobayashi, Saori Toujima, Michihisa Shiro, Mika Mizoguchi, Yasushi Mabuchi, Shigetaka Yagi, Sawako Minami, Osamu Takikawa and Kazuhiko Ino

      Article first published online: 27 JUN 2014 | DOI: 10.1111/cas.12445

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      Tumor-derived IDO promotes the peritoneal dissemination and progression of ovarian cancer through inducing an immunotolerogenic tumor microenvironment.

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