Cancer Science

Cover image for Vol. 105 Issue 7

Early View (Online Version of Record published before inclusion in an issue)

Edited By: Yusuke Nakamura

Impact Factor: 3.534

ISI Journal Citation Reports © Ranking: 2013: 68/202 (Oncology)

Online ISSN: 1349-7006

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  1. Original Articles

    1. You have full text access to this OnlineOpen article
      WHI-P154 enhances the chemotherapeutic effect of anticancer agents in ABCG2-overexpressing cells

      Hui Zhang, Yun-Kai Zhang, Yi-Jun Wang, Rishil J. Kathawala, Atish Patel, Hua Zhu, Kamlesh Sodani, Tanaji T. Talele, Suresh V. Ambudkar, Zhe-Sheng Chen and Li-Wu Fu

      Article first published online: 21 AUG 2014 | DOI: 10.1111/cas.12462

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      Our findings highlight WHI-P154 could significantly reverse ABCG2-mediated MDR by directly blocking the efflux function of the transporter and warrants consideration for combination chemotherapy in the clinic.

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      Th17 cells and interleukin-17 increase with poor prognosis in patients with acute myeloid leukemia

      Yixiang Han, Aifang Ye, Laixi Bi, Jianbo Wu, Kang Yu and Shenghui Zhang

      Article first published online: 11 AUG 2014 | DOI: 10.1111/cas.12459

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      Elevated frequency of Th17 cells and decreased frequency of Th1 cells exist in peripheral blood mononuclear cells and bone marrow mononuclear cells from AML patients compared with healthy donors. IL-17A induces the proliferation of IL-17 receptor (IL-17R)-positive AML cells via IL-17R, in which activation of PI3K/Akt and Jak/Stat3 signaling pathway may play important roles. Th17 cells play a crucial role in the pathogenesis of AML and may be an important therapeutic target and prognostic predictor.

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      Clinical impact of c-MET expression and genetic mutational status in colorectal cancer patients after liver resection

      Hirokazu Shoji, Yasuhide Yamada, Hirokazu Taniguchi, Kengo Nagashima, Natsuko Okita, Atsuo Takashima, Yoshitaka Honma, Satoru Iwasa, Ken Kato, Tetsuya Hamaguchi and Yasuhiro Shimada

      Article first published online: 7 AUG 2014 | DOI: 10.1111/cas.12453

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      A high expression of c-MET in primary tumors was associated with worse RFS for patients who had undergone curative hepatectomy.

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      In vivo imaging of membrane type-1 matrix metalloproteinase with a novel activatable near-infrared fluorescence probe

      Yoichi Shimizu, Takashi Temma, Isao Hara, Akira Makino, Naoya Kondo, Ei-ichi Ozeki, Masahiro Ono and Hideo Saji

      Article first published online: 31 JUL 2014 | DOI: 10.1111/cas.12457

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      Schematic illustration of the design and strategy of MT1-hIC7L. Quenched MT1-hIC7L first attaches to MT1-MMP expressed on tumor cells, and is then delivered to the cell interior via MT1-MMP internalization whereupon fluorescence signals are emitted following probe degradation.

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      Antitumor effect of nuclear factor-κB decoy transfer by mannose-modified bubble lipoplex into macrophages in mouse malignant ascites

      Yusuke Kono, Shigeru Kawakami, Yuriko Higuchi, Kazuo Maruyama, Fumiyoshi Yamashita and Mitsuru Hashida

      Article first published online: 31 JUL 2014 | DOI: 10.1111/cas.12452

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      We demonstrated that the combinatorial use of mannose-modified bubble lipoplexes with ultrasound exposure achieved the efficient delivery of NF-κB decoy oligonucleotides into tumor-associated macrophages (TAM) in a mouse peritoneal dissemination model of Ehrlich ascites carcinoma. Using this method, NF-κB decoy transfer into TAM inhibited the malignant ascites progression significantly that may be the phenotypic conversion of TAM from M2 toward M1.

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      Baseline carcinoembryonic antigen (CEA) serum levels predict bevacizumab-based treatment response in metastatic colorectal cancer

      Gerald W. Prager, Kira H. Braemswig, Alexandra Martel, Matthias Unseld, Georg Heinze, Thomas Brodowicz, Werner Scheithauer, Gabriela Kornek and Christoph C. Zielinski

      Article first published online: 31 JUL 2014 | DOI: 10.1111/cas.12451

      Previously, we found that CEA induces angiogenesis independent of VEGF. The data presented here now give first evidence that baseline serum CEA levels in patients might constitute an important predictor for the efficacy of first-line bevacizumab-based therapy for metastatic colorectal cancer.

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      Platelets promote osteosarcoma cell growth through activation of the platelet-derived growth factor receptor-Akt signaling axis

      Satoshi Takagi, Ai Takemoto, Miho Takami, Tomoko Oh-hara and Naoya Fujita

      Article first published online: 28 JUL 2014 | DOI: 10.1111/cas.12464

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      Analysis of phospho-antibody arrays revealed that co-culture of osteosarcoma cells with platelets induced the phosphorylation of PDGFR and Akt. Detailed analysis suggest that PDGF released from platelets plays an important role in the proliferation of osteosarcomas by activating the PDGFR and then Akt. Our results suggest that inhibitors that specifically target osteosarcoma-platelet interactions may eradicate osteosarcomas.

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      Gambogic acid suppresses hypoxia-induced hypoxia-inducible factor-1α/vascular endothelial growth factor expression via inhibiting phosphatidylinositol 3-kinase/Akt/mammalian target protein of rapamycin pathway in multiple myeloma cells

      Fei Wang, Wei Zhang, Liting Guo, Wen Bao, Nan Jin, Ran Liu, Ping Liu, Yonghui Wang, Qinglong Guo and Baoan Chen

      Article first published online: 27 JUL 2014 | DOI: 10.1111/cas.12458

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      GA downregulate HIF-1α protein levels of U266 cells in hypoxia. The inhibition of HIF-1α/VEGF protein expression by GA is associated with the suppression of PI3K/Akt/mTOR pathway.

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      Transforming growth factor-β-induced lncRNA-Smad7 inhibits apoptosis of mouse breast cancer JygMC(A) cells

      Mayu Arase, Kana Horiguchi, Shogo Ehata, Masato Morikawa, Shuichi Tsutsumi, Hiroyuki Aburatani, Kohei Miyazono and Daizo Koinuma

      Article first published online: 25 JUL 2014 | DOI: 10.1111/cas.12454

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      A long non-coding RNA, termed lncRNA-Smad7, was identified as a target of TGF-β in mouse mammary gland epithelial cell and breast cancer cells. lncRNA-Smad7 had anti-apoptotic functions downstream of TGF-β without altering the process of TGF-β-induced epithelial–mesenchymal transition, phosphorylation of Smad2, or expression of the Smad7 gene.

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      Significance of c-MET overexpression in cytotoxic anticancer drug-resistant small-cell lung cancer cells

      Hiroaki Ozasa, Tetsuya Oguri, Ken Maeno, Osamu Takakuwa, Eiji Kunii, Yoshitaka Yagi, Takehiro Uemura, Daishi Kasai, Mikinori Miyazaki and Akio Niimi

      Article first published online: 25 JUL 2014 | DOI: 10.1111/cas.12447

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      Activation of c-MET signaling pathway through an increase in the number of c-MET gene loci is one of novel mechanisms contributing to acquired resistance to cytotoxic anticancer drugs. c-MET inhibitor may overcome the rapid development of drug resistance, which results in the poor prognosis of lung cancer patients.

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      Phase II study of zoledronic acid combined with docetaxel for non-small-cell lung cancer: West Japan Oncology Group

      Haruyasu Murakami, Takeharu Yamanaka, Takashi Seto, Kenji Sugio, Isamu Okamoto, Toshiyuki Sawa, Tomonori Hirashima, Koji Takeda, Shinji Atagi, Masahiro Fukuoka, Yoichi Nakanishi, Kazuhiko Nakagawa and Nobuyuki Yamamoto

      Article first published online: 12 JUL 2014 | DOI: 10.1111/cas.12448

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      A randomized phase II study was evaluate the efficacy and safety of zoledronic acid in combination with docetaxel in previously treated patients with non-small cell lung cancer (NSCLC) and bone metastases. This study demonstrated the safety and tolerability of the combination of zoledronic acid and docetaxel but did not meet the primary endpoint of PFS in advanced NSCLC patients with bone metastasis.

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      Newly defined aberrant crypt foci as a marker for dysplasia in the rat colon

      Masako Ochiai, Yoshitaka Hippo, Masashi Izumiya, Masatoshi Watanabe and Hitoshi Nakagama

      Article first published online: 12 JUL 2014 | DOI: 10.1111/cas.12446

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      This study provides a simple methodology for accurate detection of dysplasia by a novel type of aberrant crypt foci, directly on the whole colon without histological examination. The newly defined lesion proved superior to all the previously described pre-malignant lesions, in terms of sensitivity and specificity for dysplasia, and simplicity in detection and diagnosis, which will likely pave the way for more detailed analysis of early stages of intestinal tumor development.

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      Indoleamine 2,3-dioxygenase promotes peritoneal metastasis of ovarian cancer by inducing an immunosuppressive environment

      Yuko Tanizaki, Aya Kobayashi, Saori Toujima, Michihisa Shiro, Mika Mizoguchi, Yasushi Mabuchi, Shigetaka Yagi, Sawako Minami, Osamu Takikawa and Kazuhiko Ino

      Article first published online: 27 JUN 2014 | DOI: 10.1111/cas.12445

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      Tumor-derived IDO promotes the peritoneal dissemination and progression of ovarian cancer through inducing an immunotolerogenic tumor microenvironment.

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