High levels of DJ-1 protein and isoelectric point 6.3 isoform in sera of breast cancer patients
Takahiko Kawate, Keiichi Iwaya, Kayoko Koshikawa, Tomoyuki Moriya, Tamio Yamasaki, Sho Hasegawa, Hiroshi Kaise, Tomoyuki Fujita, Hirotaka Matsuo, Takahiro Nakamura, Takashi Ishikawa, Sadayuki Hiroi, Sanae M.M. Iguchi-Ariga, Hiroyoshi Ariga, Keiichi Murota, Minoru Fujimori, Junji Yamamoto, Osamu Matsubara and Norio Kohno
Article first published online: 6 MAY 2015 | DOI: 10.1111/cas.12673
In order to determine the clinical significance of DJ-1 protein in the sera of breast cancer patients, multicenter study was performed. The presence of the DJ-1 isoform at pI 6.3 could clearly differentiate breast cancer from non-cancerous state in patients with high levels of DJ-1 in the serum, which reflect cellular oxidative damage, a major factor of age-related diseases (cancer, neurodegenerative disorder, cardiovascular disease, diabetes, etc.).