Cancer Science

Cover image for Vol. 107 Issue 6

Early View (Online Version of Record published before inclusion in an issue)

Edited By: Yusuke Nakamura

Impact Factor: 3.896

ISI Journal Citation Reports © Ranking: 2015: 62/213 (Oncology)

Online ISSN: 1349-7006

VIEW

  1. 1 - 28
  1. Original Articles

    1. You have full text access to this OnlineOpen article
      Dynamic changes in immune cell profile in head and neck squamous cell carcinoma: Immunomodulatory effects of chemotherapy

      Hideyuki Takahashi, Koichi Sakakura, Ikko Mito, Shota Ida and Kazuaki Chikamatsu

      Version of Record online: 24 JUN 2016 | DOI: 10.1111/cas.12976

      Thumbnail image of graphical abstract

      Dynamic changes of the proportion and activation status were observed in peripheral immune regulatory cells and CD8+ T cell subsets in patients with head and neck squamous cell carcinoma. Moreover, chemotherapy triggered not only a transient reduction in immune regulatory cells but also further activation of CD8+ T cells.

    2. You have full text access to this OnlineOpen article
      Regulation of CD44 expression and focal adhesion by Golgi phosphatidylinositol 4-phosphate in breast cancer

      Takeshi Ijuin, Yukiko Takeuchi, Yohei Shimono, Miki Fukumoto, Emi Tokuda and Tadaomi Takenawa

      Version of Record online: 24 JUN 2016 | DOI: 10.1111/cas.12968

      Thumbnail image of graphical abstract

      Phosphatidylinositol-4-phosphate (PI(4)P) at the golgi regulated CD44 expression and focal adhesion formation in breast cancer cells. Knockdown of PI(4)P phosphatase SAC1 increased expression of CD44s and CD44v in breast cancer cells. Taken together, our results provide evidences that Golgi PI(4)P regulates breast cancer cell invasion and motility.

  2. Review Articles

    1. You have full text access to this OnlineOpen article
      Development of polymeric micelles for targeting intractable cancers

      Nobuhiro Nishiyama, Yasuhiro Matsumura and Kazunori Kataoka

      Version of Record online: 24 JUN 2016 | DOI: 10.1111/cas.12960

      Thumbnail image of graphical abstract

      Polymeric micelles can target lymph nodes metastasis of murine melanoma cells through not only the lymphatic route from primary tumors but also the blood vascular route.

  3. Original Articles

    1. You have full text access to this OnlineOpen article
      Multiwalled carbon nanotubes intratracheally instilled into the rat lung induce development of pleural malignant mesothelioma and lung tumors

      Masumi Suzui, Mitsuru Futakuchi, Katsumi Fukamachi, Takamasa Numano, Mohamed Abdelgied, Satoru Takahashi, Makoto Ohnishi, Toyonori Omori, Shuji Tsuruoka, Akihiko Hirose, Jun Kanno, Yoshimitsu Sakamoto, David B. Alexander, William T. Alexander, Xu Jiegou and Hiroyuki Tsuda

      Version of Record online: 23 JUN 2016 | DOI: 10.1111/cas.12954

      Thumbnail image of graphical abstract

      Rats were administered 0.125 mg MWCNT-N via the airway using intratracheal instillation every other day for two weeks (total 1 mg/rat). MWCNT intratracheally instilled into the rat lung induced development of malignant mesothelioma and lung tumors.

    2. You have full text access to this OnlineOpen article
      Tumor-associated macrophages induce capillary morphogenesis of lymphatic endothelial cells derived from human gastric cancer

      Yukie Tauchi, Hiroaki Tanaka, Kanako Kumamoto, Mao Tokumoto, Chie Sakimura, Katsunobu Sakurai, Kenjiro Kimura, Takahiro Toyokawa, Ryosuke Amano, Naoshi Kubo, Kazuya Muguruma, Masakazu Yashiro, Kiyoshi Maeda, Masaichi Ohira and Kosei Hirakawa

      Version of Record online: 22 JUN 2016 | DOI: 10.1111/cas.12977

      Thumbnail image of graphical abstract

      In this study, we explored the macrophage-induced lymphangiogenesis, which is promoted in tumor microenvironment. We showed that direct interaction between macrophages and lymphatic endothelial cells could be the initial step of metastatic spread of lymph nodes in gastric cancer.

    3. You have full text access to this OnlineOpen article
      New mouse model of acute adult T-cell leukemia generated by transplantation of AKT, BCLxL, and HBZ-transduced T cells

      Yumiko Kasugai, Noriaki Yoshida, Koichi Ohshima, Keitaro Matsuo, Masao Seto and Shinobu Tsuzuki

      Version of Record online: 22 JUN 2016 | DOI: 10.1111/cas.12974

      Thumbnail image of graphical abstract

      Adult T cell leukemia is an intractable cancer and prevalent in Japan. Recently, a comprehensive study of gene mutations in ATL has been reported, but their roles in ATL development are not explored partly due to the lack of an animal model that allows rapid generation of ATL-like disease. Here, we present such a model mouse, which is a versatile tool to study roles of mutated genes in ATL development.

    4. You have full text access to this OnlineOpen article
      Induction of apoptosis by HBI-8000 in adult T-cell leukemia/lymphoma is associated with activation of Bim and NLRP3

      Hiroo Hasegawa, Reid P. Bissonnette, Mireille Gillings, Daisuke Sasaki, Hiroaki Taniguchi, Hideaki Kitanosono, Kazuto Tsuruda, Kousuke Kosai, Naoki Uno, Yoshitomo Morinaga, Yoshitaka Imaizumi, Yasushi Miyazaki and Katsunori Yanagihara

      Version of Record online: 22 JUN 2016 | DOI: 10.1111/cas.12971

      Thumbnail image of graphical abstract

      HBI-8000, a novel oral histone deacetylase inhibitor, induced apoptosis in both primary ATL cells and cell lines. In addition, findings obtained with DNA microarray analysis revealed that activation of Bim and NLRP3 inflammasome pathway is critical. Our results provide a rationale for a clinical investigation of the efficacy of HBI-8000 in patients with ATL. HBI-8000 may be part of a novel therapeutic strategy for cancer based on the NLRP3 pathway.

    5. You have full text access to this OnlineOpen article
      World Health Organization grade II–III astrocytomas consist of genetically distinct tumor lineages

      Natsuki Hattori, Yuichi Hirose, Hikaru Sasaki, Shunsuke Nakae, Saeko Hayashi, Shigeo Ohba, Kazuhide Adachi, Takuro Hayashi, Yuya Nishiyama, Mitsuhiro Hasegawa and Masato Abe

      Version of Record online: 22 JUN 2016 | DOI: 10.1111/cas.12969

      Thumbnail image of graphical abstract

      Genetic subgrouping based on DNA copy number aberrations and IDH1 gene mutations revealed grade II–III astrocytomas consist of multiple lineages. The differences in their biological nature should be taken into consideration during their clinical management.

    6. You have full text access to this OnlineOpen article
      Bystander killing effect of DS-8201a, a novel anti-human epidermal growth factor receptor 2 antibody–drug conjugate, in tumors with human epidermal growth factor receptor 2 heterogeneity

      Yusuke Ogitani, Katsunobu Hagihara, Masataka Oitate, Hiroyuki Naito and Toshinori Agatsuma

      Version of Record online: 22 JUN 2016 | DOI: 10.1111/cas.12966

      Thumbnail image of graphical abstract

      Bystander killing effect of DS-8201a was evaluated by detecting HER2-negative cells using an in vivo imaging system. DS-8201a killed HER2-negative cells under co-inoculating condition in both HER2-positive and negative cells.

    7. You have full text access to this OnlineOpen article
      MicroRNA-124-3p regulates cell proliferation, invasion, apoptosis, and bioenergetics by targeting PIM1 in astrocytoma

      Danni Deng, Lei Wang, Yao Chen, Bowen Li, Lian Xue, Naiyuan Shao, Qiang Wang, Xiwei Xia, Yilin Yang and Feng Zhi

      Version of Record online: 21 JUN 2016 | DOI: 10.1111/cas.12946

      Thumbnail image of graphical abstract

      miR-124-3p inhibits astrocytoma cancer cell proliferation, invasion and aerobic glycolysis, and promotes apoptosis in vitro.

    8. You have full text access to this OnlineOpen article
      Combination of panobinostat with ponatinib synergistically overcomes imatinib-resistant CML cells

      Yasufumi Matsuda, Takahiro Yamauchi, Naoko Hosono, Kanako Uzui, Eiju Negoro, Koji Morinaga, Rie Nishi, Akira Yoshida, Shinya Kimura, Taira Maekawa and Takanori Ueda

      Version of Record online: 21 JUN 2016 | DOI: 10.1111/cas.12965

      Thumbnail image of graphical abstract

      A combination of panobinostat and ponatinib synergistically overcame imatinib-resistant chronic myeloid leukemia cells including BCR-ABL T315I mutation. The combination of these two agents might offer a new therapeutic strategy with excellent anti-CML activity.

    9. You have full text access to this OnlineOpen article
      Rebiopsy for patients with non-small-cell lung cancer after epidermal growth factor receptor-tyrosine kinase inhibitor failure

      Takahisa Kawamura, Hirotsugu Kenmotsu, Tetsuhiko Taira, Shota Omori, Kazuhisa Nakashima, Kazushige Wakuda, Akira Ono, Tateaki Naito, Haruyasu Murakami, Keita Mori, Takashi Nakajima, Yasuhisa Ohde, Masahiro Endo and Toshiaki Takahashi

      Version of Record online: 21 JUN 2016 | DOI: 10.1111/cas.12963

      Thumbnail image of graphical abstract

      Rebiopsy for detecting acquired EGFR T790 M mutations can be challenging for both patients and physicians. We aimed to investigate factors that keep patients from undergoing rebiopsies, and other issues in these procedures and their outcomes.

    10. You have full text access to this OnlineOpen article
      CD44 variant-dependent redox status regulation in liver fluke-associated cholangiocarcinoma: A target for cholangiocarcinoma treatment

      Malinee Thanee, Watcharin Loilome, Anchalee Techasen, Eiji Sugihara, Shogo Okazaki, Shinya Abe, Shiho Ueda, Takashi Masuko, Nisana Namwat, Narong Khuntikeo, Attapol Titapun, Chawalit Pairojkul, Hideyuki Saya and Puangrat Yongvanit

      Version of Record online: 20 JUN 2016 | DOI: 10.1111/cas.12967

      Thumbnail image of graphical abstract

      The redox status regulation of CCA cells depends on the expression of CD44v to contribute the xCT function and is a link to the carcinogenesis and poor prognosis of patients.

    11. You have full text access to this OnlineOpen article
      Dose escalation study of proton beam therapy with concurrent chemotherapy for stage III non-small cell lung cancer

      Hideyuki Harada, Hiroshi Fuji, Akira Ono, Hirotsugu Kenmotsu, Tateaki Naito, Haruo Yamashita, Hirofumi Asakura, Tetsuo Nishimura, Toshiaki Takahashi and Shigeyuki Murayama

      Version of Record online: 20 JUN 2016 | DOI: 10.1111/cas.12955

      Thumbnail image of graphical abstract

      This is a dose-finding study for locally advanced non-small cell lung cancer using proton beam therapy and concurrent chemotherapy. We tested two doses of proton beam therapy, namely 66 Gy(RBE) and 74 Gy (RBE). From overall clinical viewpoints, 66 Gy (RBE) was determined as the recommended dose for future clinical trials.

  4. Review Articles

    1. You have full text access to this OnlineOpen article
      To wake up cancer stem cells, or to let them sleep, that is the question

      Shoichiro Takeishi and Keiichi I. Nakayama

      Version of Record online: 20 JUN 2016 | DOI: 10.1111/cas.12958

      Thumbnail image of graphical abstract

      Intrinsic and extrinsic regulation of CSC behavior. CSC quiescence is regulated by internal molecules as well as by those in the CSC niche.

  5. Retraction

    1. You have full text access to this Open Access content
  6. Original Articles

    1. You have full text access to this OnlineOpen article
      A prognostic risk model for patients with triple negative breast cancer based on stromal natural killer cells, tumor-associated macrophages and growth-arrest specific protein 6

      Wenjing Tian, Le Wang, Lili Yuan, Wenming Duan, Wenhui Zhao, Shuhuai Wang and Qingyuan Zhang

      Version of Record online: 14 JUN 2016 | DOI: 10.1111/cas.12964

      Thumbnail image of graphical abstract

      The prognostic risk model showed significant effect on overall survivals of triple negative breast cancer patients. The prognostic risk score of this model was a significant indicator of prognosis for patients with triple negative breast cancer.

    2. You have full text access to this OnlineOpen article
      Prognosis of metastatic renal cell carcinoma with first-line interferon-α therapy in the era of molecular-targeted therapy

      Yoshiaki Kawano, Wataru Takahashi, Masatoshi Eto, Tomomi Kamba, Hideaki Miyake, Masato Fujisawa, Takao Kamai, Hirotsugu Uemura, Taiji Tsukamoto, Haruhito Azuma, Akio Matsubara, Kazuo Nishimura, Tsuyoshi Nakamura, Osamu Ogawa and Seiji Naito

      Version of Record online: 14 JUN 2016 | DOI: 10.1111/cas.12951

      Thumbnail image of graphical abstract

      In this study, the authors show remarkably extended overall survival of metastatic renal cell carcinoma (mRCC) patients whose first-line therapy was IFN-α in the era of molecular targeted therapy, compared to the previous studies. This study suggests that IFN-α is not a “vintage” option yet but still a useful agent for mRCC as first-line treatment even in the post-cytokine era, particularly in the context of sequential therapy with molecular targeted agents.

    3. You have full text access to this OnlineOpen article
      C-terminal Src kinase-mediated EPIYA phosphorylation of Pragmin creates a feed-forward C-terminal Src kinase activation loop that promotes cell motility

      Yoshie Senda, Naoko Murata-Kamiya and Masanori Hatakeyama

      Version of Record online: 13 JUN 2016 | DOI: 10.1111/cas.12962

      Thumbnail image of graphical abstract

      Pragmin is one of the few mammalian proteins containing the EPIYA tyrosine-phosphorylation motif. Here we found that the Pragmin–C-terminal Src kinase (Csk) interaction, triggered by the EPIYA phosphorylation of Pragmin, creates a feed-forward regulatory loop of Csk kinase activation at focal adhesions, which induces cell-morphological transformation and cell scattering. Deregulation of the Pragmin–Csk axis may induce abnormal cell migration and invasion that contribute to tumor invasion and metastasis.

    4. You have full text access to this OnlineOpen article
      Utility of KRAS mutation detection using circulating cell-free DNA from patients with colorectal cancer

      Takeshi Yamada, Takuma Iwai, Goro Takahashi, Hayato Kan, Michihiro Koizumi, Akihisa Matsuda, Seiichi Shinji, Aya Yamagishi, Yasuyuki Yokoyama, Atsushi Tatsuguchi, Tatsuro Kawagoe, Shiro Kitano, Masato Nakayama, Satoshi Matsumoto and Eiji Uchida

      Version of Record online: 13 JUN 2016 | DOI: 10.1111/cas.12959

      Thumbnail image of graphical abstract

      We showed the usefulness of detecting KRAS mutations in cell-free DNA in patients with KRAS wild-type and mutated colorectal cancer using our new high-sensitivity method and digital PCR. It is as an attractive method for predicting patient prognosis, monitoring tumor progression, and predicting response to epidermal growth factor receptor (EGFR) blockade, allowing for more personalized patient care. Moreover, we showed the utility of detection of KRAS mutations in cell-free DNA as a biomarker for early detection of recurrence in patients with KRAS mutated tumors.

    5. You have full text access to this OnlineOpen article
      Identification of cooperative genes for E2A-PBX1 to develop acute lymphoblastic leukemia

      Yasuyuki Sera, Norimasa Yamasaki, Hideaki Oda, Akiko Nagamachi, Linda Wolff, Takeshi Inukai, Toshiya Inaba and Hiroaki Honda

      Version of Record online: 13 JUN 2016 | DOI: 10.1111/cas.12945

    6. You have full text access to this OnlineOpen article
      miR-199a-5p regulates β1 integrin through Ets-1 to suppress invasion in breast cancer

      Wentong Li, Hui Wang, Jinbao Zhang, Limin Zhai, Weijuan Chen and Chunling Zhao

      Version of Record online: 13 JUN 2016 | DOI: 10.1111/cas.12952

      Thumbnail image of graphical abstract

      Our results provide insight into the regulation of β1 integrin through miR-199a-5p-mediated Ets-1 silence and help in designing new therapeutic strategies to inhibit signal pathways induced by miR-199a-5p in breast cancer invasion.

    7. You have full text access to this OnlineOpen article
      Equol inhibits prostate cancer growth through degradation of androgen receptor by S-phase kinase-associated protein 2

      Momoe Itsumi, Masaki Shiota, Ario Takeuchi, Eiji Kashiwagi, Junichi Inokuchi, Katsunori Tatsugami, Shunichi Kajioka, Takeshi Uchiumi, Seiji Naito, Masatoshi Eto and Akira Yokomizo

      Version of Record online: 13 JUN 2016 | DOI: 10.1111/cas.12948

      Thumbnail image of graphical abstract

      In this study, we revealed that the soy isoflavones, especially equol, inhibit AR expression in prostate cancer cell lines. Furthermore, we found that the mechanism of AR inhibition by equol is mediated by Skp2.

    8. You have full text access to this OnlineOpen article
      Chronic mesothelial reaction and toxicity of potassium octatitanate fibers in the pleural cavity in mice and F344 rats

      Masanao Yokohira, Yuko Nakano-Narusawa, Keiko Yamakawa, Nozomi Hashimoto, Shota Yoshida, Shohei Kanie and Katsumi Imaida

      Version of Record online: 13 JUN 2016 | DOI: 10.1111/cas.12944

      Thumbnail image of graphical abstract

      This study demonstrated that intra-thoracic infusion of TISMO fiber did not cause malignant mesothelioma but did cause severe chronic inflammation and proliferation of pleural mesothelial cells in all strains of mice and rats.

    9. You have full text access to this OnlineOpen article
      Combined inhibition of EZH2 and histone deacetylases as a potential epigenetic therapy for non-small-cell lung cancer cells

      Taichi Takashina, Ichiro Kinoshita, Junko Kikuchi, Yasushi Shimizu, Jun Sakakibara-Konishi, Satoshi Oizumi, Masaharu Nishimura and Hirotoshi Dosaka-Akita

      Version of Record online: 13 JUN 2016 | DOI: 10.1111/cas.12957

      Thumbnail image of graphical abstract

      The present study clearly demonstrated that the combined therapy with inhibitors of the histone methylase EZH2 and the histone de acetylases HDACs had a synergistic growth suppressive effect and induced substantial apoptosis in NSCLC cells. Interestingly, the co-treatment suppressed the in vivo tumor growth of EGFR-mutant, EGFR-TKI-resistant H1975 cells more effectively than single treatment via inhibition of the EGFR signaling pathway, suggesting that the combined pharmacological targeting of the histone modification enzymes may provide more effective epigenetic therapeutics for NSCLC including that with EGFR-TKI-resistant mutations.

    10. You have full text access to this OnlineOpen article
      Dual preventive benefits of iron elimination by desferal in asbestos-induced mesothelial carcinogenesis

      Li Jiang, Shan-Hwu Chew, Kosuke Nakamura, Yuuki Ohara, Shinya Akatsuka and Shinya Toyokuni

      Version of Record online: 13 JUN 2016 | DOI: 10.1111/cas.12947

      Thumbnail image of graphical abstract

      Immunohistochemical analysis of 8-OHdG of the peritoneal mesothelial cells after asbestos injection in the presence or absence of iron chelators revealed that NTA increased mesothelial nuclear 8-OHdG whereas desferal decreased it. Desferal presents dual merits for mesothelioma prevention after asbestos exposure by quenching inflammation and suppressing mesothelioma proliferation.

    11. You have full text access to this OnlineOpen article
      B7-H4 facilitates proliferation of esophageal squamous cell carcinoma cells through promoting interleukin-6/signal transducer and activator of transcription 3 pathway activation

      Xinran Chen, Ling Wang, Wei Wang, Lianmei Zhao and Baoen Shan

      Version of Record online: 27 MAY 2016 | DOI: 10.1111/cas.12949

      Thumbnail image of graphical abstract

      STAT3 is mainly located in the nucleus, with small part distributing in the cytoplasm, in ESCC cells.

    12. You have full text access to this OnlineOpen article
      Linkage of E2F1 transcriptional network and cell proliferation with respiratory chain activity in breast cancer cells

      Kazunori Mori, Tetsu Uchida, Motonori Fukumura, Shigetoshi Tamiya, Masato Higurashi, Hirosato Sakai, Fumihiro Ishikawa and Motoko Shibanuma

      Version of Record online: 20 MAY 2016 | DOI: 10.1111/cas.12953

      Thumbnail image of graphical abstract

      A novel coupling between ETC activity and the core regulatory machinery for cell cycle progression.

VIEW

  1. 1 - 28

SEARCH

SEARCH BY CITATION