Cancer Science

Cover image for Vol. 107 Issue 9

Early View (Online Version of Record published before inclusion in an issue)

Edited By: Yusuke Nakamura

Impact Factor: 3.896

ISI Journal Citation Reports © Ranking: 2015: 62/213 (Oncology)

Online ISSN: 1349-7006

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  1. 1 - 19
  1. Original Articles

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      Comparison of methods using paraffin-embedded tissues and exfoliated cervical cells to evaluate human papillomavirus genotype attribution

      Yutaka Torii, Takuma Fujii, Iwao Kukimoto, Miyuki Saito, Takashi Iwata, Hiroshi Takahashi, Ryoko Ichikawa, Satoshi Kawai, Sayaka Otani and Daisuke Aoki

      Version of Record online: 24 SEP 2016 | DOI: 10.1111/cas.13030

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      In the present retrospective cross-sectional study for efficacy monitoring of human papillomavirus (HPV) vaccines, we compared three procedures for HPV genotyping using readily available cervical exfoliated cells relative to conventionally used formalin-fixed paraffin-embedded (FFPE) tissues. We suggest that the Clinichip® HPV test and modified GP5+/6+ PCR coupled with fluorescent bead sorter detection methods coupled with the hierarchical attribution formula can be used with cervical exfoliated cells for efficacy monitoring of HPV vaccines.

  2. Review Articles

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      Glycogen synthase kinase-3β is a pivotal mediator of cancer invasion and resistance to therapy

      Takahiro Domoto, Ilya V. Pyko, Takuya Furuta, Katsuyoshi Miyashita, Masahiro Uehara, Takeo Shimasaki, Mitsutoshi Nakada and Toshinari Minamoto

      Version of Record online: 24 SEP 2016 | DOI: 10.1111/cas.13028

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      Tumor invasion and therapy resistance are inextricably linked to each other in refractory cancer, thereby presenting challenges to current cancer treatment paradigms. Increasing evidence of an unexpected role for GSK3β in sustaining tumor cell survival and proliferation underpins the targeting of GSK3β as a novel cancer treatment. This review provides new insights into the unwanted association between cancer invasion and therapy resistance by focusing on previously unrecognized functions of GSK3β as a molecular hub that integrates distinct biological pathways.

  3. Original Articles

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      FBXW7 is involved in the acquisition of the malignant phenotype in epithelial ovarian tumors

      Shoko Kitade, Ichiro Onoyama, Hiroaki Kobayashi, Hiroshi Yagi, Sachiko Yoshida, Masaya Kato, Ryosuke Tsunematsu, Kazuo Asanoma, Kenzo Sonoda, Norio Wake, Kenichiro Hata, Keiichi I. Nakayama and Kiyoko Kato

      Version of Record online: 24 SEP 2016 | DOI: 10.1111/cas.13026

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      FBXW7 is a known tumor-suppressor gene, and mutations in FBXW7 have been reported in various human malignancies. In this study, we found that the expression level of FBXW7 was correlated with the malignant potential of epithelial ovarian tumor other than mutational status of FBXW7. This is the first report that FBXW7 expression was downregulated in ovarian cancer and that p53 mutational status had an impact on the DNA methylation status of the 5′-upstream regions of FBXW7.

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      Calpain inhibitor calpeptin suppresses pancreatic cancer by disrupting cancer–stromal interactions in a mouse xenograft model

      Masaki Yoshida, Yoshihiro Miyasaka, Kenoki Ohuchida, Takashi Okumura, Biao Zheng, Nobuhiro Torata, Hayato Fujita, Toshinaga Nabae, Tatsuya Manabe, Masaya Shimamoto, Takao Ohtsuka, Kazuhiro Mizumoto and Masafumi Nakamura

      Version of Record online: 24 SEP 2016 | DOI: 10.1111/cas.13024

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      Calpeptin, a calpain inhibitor, reduced the volume of xenograft tumors containing pancreatic cancer cells (PCCs) and pancreatic stellate cells (PSCs). Calpeptin suppressed proliferation, migration, and invasion of PCCs and PSCs. Furthermore, calpeptin reduced the migration of PCCs and PSCs by disrupting the cancer-stromal interaction.

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      Phase I, multicenter, open-label, dose-escalation study of sonidegib in Asian patients with advanced solid tumors

      Hironobu Minami, Yuichi Ando, Brigette Buig Yue Ma, Jih- Hsiang Lee, Hiroyuki Momota, Yutaka Fujiwara, Leung Li, Koichi Fukino, Koji Ito, Takeshi Tajima, Asuka Mori and Chia-Chi Lin

      Version of Record online: 24 SEP 2016 | DOI: 10.1111/cas.13022

      Sonidegib showed a similar safety profile in East Asian patients as that of Western population. No new AEs were reported in the Asian population. The recommended dose of sonidegib in East Asian patients (400 mg) was lower than Western MTD (800 mg daily or 250 mg twice daily) suggesting a difference in tolerability between the 2 populations.

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      Patritumab plus trastuzumab and paclitaxel in human epidermal growth factor receptor 2-overexpressing metastatic breast cancer

      Hirofumi Mukai, Toshiaki Saeki, Kenjiro Aogi, Yoichi Naito, Nobuaki Matsubara, Takashi Shigekawa, Shigeto Ueda, Seiki Takashima, Fumikata Hara, Tomonari Yamashita, Shoichi Ohwada and Yasutsuna Sasaki

      Version of Record online: 15 SEP 2016 | DOI: 10.1111/cas.13017

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      We examined the safety and pharmacokinetics of patritumab, a human anti-HER3 monoclonal antibody that has shown anticancer activity in preclinical models, in combination with trastuzumab and paclitaxel in patients with HER2-overexpressing metastatic breast cancer. No dose-limiting toxicities were observed, and the target trough serum concentration was achieved in all patients at a dose of 18 mg/kg. Patritumab plus trastuzumab and paclitaxel was tolerable and efficacious at both doses, but we recommend the 18 mg/kg dose for future studies.

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      Negative prognostic impact of low absolute CD4+ T cell counts in peripheral blood in mantle cell lymphoma

      Xin-Yu Zhang, Ji Xu, Hua-Yuan Zhu, Yan Wang, Li Wang, Lei Fan, Yu-Jie Wu, Jian-Yong Li and Wei Xu

      Version of Record online: 14 SEP 2016 | DOI: 10.1111/cas.13020

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      We studied 68 consecutive patients with mantle cell lymphoma (MCL) and found that low CD4+ T cell counts (<0.445 × 109/L) were associated with inferior overall survival (OS) by both univariate analysis and multivariate analysis. So we suppose that evaluation of peripheral blood CD4+ T cell counts could be a useful indicator of clinical outcome in MCL patients.

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      Loss of YAP1 defines neuroendocrine differentiation of lung tumors

      Takeshi Ito, Daisuke Matsubara, Ichidai Tanaka, Kanae Makiya, Zen-ichi Tanei, Yuki Kumagai, Shu-Jen Shiu, Hiroki J. Nakaoka, Shumpei Ishikawa, Takayuki Isagawa, Teppei Morikawa, Aya Shinozaki-Ushiku, Yasushi Goto, Tomoyuki Nakano, Takehiro Tsuchiya, Hiroyoshi Tsubochi, Daisuke Komura, Hiroyuki Aburatani, Yoh Dobashi, Jun Nakajima, Shunsuke Endo, Masashi Fukayama, Yoshitaka Sekido, Toshiro Niki and Yoshinori Murakami

      Version of Record online: 9 SEP 2016 | DOI: 10.1111/cas.13013

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      YAP1 is possibly involved in the regulation of neuroendocrine differentiation of lung tumors. Loss of YAP1 correlated with strong expression of neuroendocrine markers. Loss of YAP1 is a predictor of chemothensitivity in high-grade neuroendocrine tumors.

  4. Review Articles

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      Oncolytic virus therapy: A new era of cancer treatment at dawn

      Hiroshi Fukuhara, Yasushi Ino and Tomoki Todo

      Version of Record online: 9 SEP 2016 | DOI: 10.1111/cas.13027

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      Oncolytic virus therapy is rapidly emerging as a new approach of cancer treatment. This review depicts this new trend of cancer therapy, in which the common feature that is expected to play a major role in prolonging the survival of cancer patients is an induction of specific antitumor immunity in the course of tumor specific viral replication. It is likely that cancer patients will be able to choose oncolytic virus therapy freely as a treatment option in the very near future.

  5. Original Articles

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      Role of galectin-1 in urinary bladder urothelial carcinoma cell invasion through the JNK pathway

      Kun-Hung Shen, Chien-Feng Li, Lan-Hsiang Chien, Cheng-Hao Huang, Chia-Cheng Su, Alex C. Liao and Ting-Feng Wu

      Version of Record online: 4 SEP 2016 | DOI: 10.1111/cas.13016

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      Galectin-1 participated in bladder cancer cell invasion through mediating the activity of matrix metalloproteinase 9 via Ras–Rac1–MAP/ERK kinase kinase 4–c-Jun N-terminal protein kinase–AP1 signaling pathway.

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      Quantitative assessment of chemotherapy-induced peripheral neurotoxicity using a point-of-care nerve conduction device

      Ayumu Matsuoka, Ayako Mitsuma, Osamu Maeda, Hiroaki Kajiyama, Hitoshi Kiyoi, Yasuhiro Kodera, Masato Nagino, Hidemi Goto and Yuichi Ando

      Version of Record online: 2 SEP 2016 | DOI: 10.1111/cas.13010

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      Chemotherapy-induced peripheral neurotoxicity (CIPN) seriously impairs patients’ quality of life. Because assessment of CIPN usually depends on patients’ subjective evaluation of symptoms, objective and quantitative measures are needed. We validated a point-of-care nerve conduction device, which has been originally developed for the assessment of diabetic peripheral neuropathy, in patients who had been given a clinical diagnosis of CIPN.

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      Clinical features and prognosis of patients with myelodysplastic syndromes who were exposed to atomic bomb radiation in Nagasaki

      Masatoshi Matsuo, Masako Iwanaga, Hisayoshi Kondo, Midori Soda, Tatsuro Jo, Kensuke Horio, Yumi Takasaki, Yasuhisa Kawaguchi, Hideki Tsushima, Yoshitaka Imaizumi, Daisuke Imanishi, Jun Taguchi, Yasushi Sawayama, Tomoko Hata and Yasushi Miyazaki

      Version of Record online: 2 SEP 2016 | DOI: 10.1111/cas.13025

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      We analyzed the impact of radiation exposure on the prognosis of MDS patients occurred in Nagasaki atomic bomb survivors. Compared to other groups, patients exposed at 1.5 km or less from the hypocenter (exposed to higher radiation dose) had significantly higher frequencies of abnormal chromosome and intermediate or more IPSS and IPSS-R cytogenetic risks, and had tended to progress to leukemia as earlier years within 10 years after the diagnosis.

  6. Review Articles

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      Application of glycoscience to the early detection of pancreatic cancer

      Eiji Miyoshi and Yoshihiro Kamada

      Version of Record online: 2 SEP 2016 | DOI: 10.1111/cas.13011

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      This manuscript is a summary of our researches about a novel glyco-cancer biomarker, fucosylated haptoglobin (Fuc-Hpt), in pancreatic cancer over approximately 10 years

  7. Original Articles

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      Podocalyxin-like protein, linked to poor prognosis of pancreatic cancers, promotes cell invasion by binding to gelsolin

      Keisuke Taniuchi, Mutsuo Furihata, Seiji Naganuma, Ken Dabanaka, Kazuhiro Hanazaki and Toshiji Saibara

      Version of Record online: 2 SEP 2016 | DOI: 10.1111/cas.13018

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      The cell-adhesion glycoprotein PODXL is associated with an aggressive tumor phenotype in several forms of cancer. High PODXL expression is an independent predictor of worse overall survival of pancreatic cancer patients, and that PODXL promotes pancreatic cancer cell motility and invasion by physically binding to the cytoskeletal protein gelsolin.

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      Small-molecule Hedgehog inhibitor attenuates the leukemia-initiation potential of acute myeloid leukemia cells

      Nobuaki Fukushima, Yosuke Minami, Seiji Kakiuchi, Yachiyo Kuwatsuka, Fumihiko Hayakawa, Catoriona Jamieson, Hitoshi Kiyoi and Tomoki Naoe

      Version of Record online: 2 SEP 2016 | DOI: 10.1111/cas.13019

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      HP1 regulates the localization of FANCJ at sites of DNA double-strand breaks

      Wenwen Wu, Yukiko Togashi, Yoshikazu Johmura, Yasuo Miyoshi, Sachihiko Nobuoka, Makoto Nakanishi and Tomohiko Ohta

      Version of Record online: 1 SEP 2016 | DOI: 10.1111/cas.13008

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      Authors demonstrate distinct mechanisms for the localization of the three BRCA1-BRCT-binding proteins, FANCJ, CtIP and RAP80, at sites of DNA double-strand breaks. The RNF8/RNF168/ubiquitin pathway is not upstream of the BRCA1-FANCJ and BRCA1-CtIP complexes, which are instead regulated by HP1 pathway.

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      HBx mutations promote hepatoma cell migration through the Wnt/β-catenin signaling pathway

      Zhen Chen, Jia Tang, Xuefei Cai, Yao Huang, Qingzhu Gao, Li Liang, Ling Tian, Yi Yang, Yaqiu Zheng, Yuan Hu and Ni Tang

      Version of Record online: 1 SEP 2016 | DOI: 10.1111/cas.13014

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      Our results indicate that HBx mutants, especially the Combo mutant, allow constitutive activation of the Wnt signaling pathway and may play a pivotal role in HBV-associated hepatocarcinogenesis.

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      High-dose methotrexate following intravitreal methotrexate administration in preventing central nervous system involvement of primary intraocular lymphoma

      Hiroki Akiyama, Hiroshi Takase, Fumito Kubo, Tohru Miki, Masahide Yamamoto, Makoto Tomita, Manabu Mochizuki, Osamu Miura and Ayako Arai

      Version of Record online: 1 SEP 2016 | DOI: 10.1111/cas.13012

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      Systemic high-dose MTX following intravitreal MTX was effective in preventing CNS involvement of PIOL in comparison with intravitreal MTX. Adverse events of intravitreal and systemic high-dose MTX were mild and tolerable.

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      P38 pathway as a key downstream signal of connective tissue growth factor to regulate metastatic potential in non-small-cell lung cancer

      Shinichiro Kato, Satoru Yokoyama, Yoshihiro Hayakawa, Luhui Li, Yusuke Iwakami, Hiroaki Sakurai and Ikuo Saiki

      Version of Record online: 1 SEP 2016 | DOI: 10.1111/cas.13009

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      CTGF/p38 axis is a novel therapeutic target of NSCLC metastasis particularly those secreting low level of CTGF.

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