Loss of YAP1 defines neuroendocrine differentiation of lung tumors
Takeshi Ito, Daisuke Matsubara, Ichidai Tanaka, Kanae Makiya, Zen-ichi Tanei, Yuki Kumagai, Shu-Jen Shiu, Hiroki J. Nakaoka, Shumpei Ishikawa, Takayuki Isagawa, Teppei Morikawa, Aya Shinozaki-Ushiku, Yasushi Goto, Tomoyuki Nakano, Takehiro Tsuchiya, Hiroyoshi Tsubochi, Daisuke Komura, Hiroyuki Aburatani, Yoh Dobashi, Jun Nakajima, Shunsuke Endo, Masashi Fukayama, Yoshitaka Sekido, Toshiro Niki and Yoshinori Murakami
Version of Record online: 9 SEP 2016 | DOI: 10.1111/cas.13013
YAP1 is possibly involved in the regulation of neuroendocrine differentiation of lung tumors. Loss of YAP1 correlated with strong expression of neuroendocrine markers. Loss of YAP1 is a predictor of chemothensitivity in high-grade neuroendocrine tumors.