© Stichting International Foundation for Animal Genetics
Edited By: Hans Lenstra
Impact Factor: 1.779
ISI Journal Citation Reports © Ranking: 2015: 8/58 (Agriculture Dairy & Animal Science); 123/166 (Genetics & Heredity)
Online ISSN: 1365-2052
Dr. Johannes A. Lenstra is Editor-in-Chief. Read the editorial about the editors by ISAG President Ernie Bailey here.
Hans Lenstra (Utrecht University, Netherlands) has a background in chemistry and biochemistry. For forty years he has worked on the molecular evolution, eukaryotic gene structure, genome characterization and molecular diversity of livestock and wildlife.
Two papers from 48.3 illustrate in two different species that copy number variation (CNV) near genes essential for development may interfere with development. Bordbari and coauthors present evidence that craniocervical malformations in horse are associated with a 2.7 kb deletion in the HOXDl locus. In the study of Nowacka-Woszuk et al. a CNV near SOX9, the X-chromosomal analogue of SRY, was implicated in canine disorder of sex development. This CNV was found to contain genes coding for homeobox protein and a long intergenic non-coding RNA, which probably increase the expression of SOX9. Especially the last study shows that the effect of mutations can be more complex than the familiar loss-of-function effect and involves molecular mechanisms that are not yet fully understood.
Read for FREE the Editor's Choice papers from Issue 48.3: Deletion of 2.7 kb near HOXD3 in an Arabian horse with occipitoatlantoaxial malformation and Deep sequencing of a candidate region harboring the SOX9 gene for the canine XX disorder of sex development.
Recently Published Articles
- Whole genome sequencing reveals a novel deletion variant in the KIT gene in horses with white spotted coat colour phenotypes
N. Dürig, R. Jude, H. Holl, S. A. Brooks, C. Lafayette, V. Jagannathan and T. Leeb
Version of Record online: 26 APR 2017 | DOI: 10.1111/age.12556
- Haplotype structure and copy number polymorphism of the beta-defensin 7 genes in diverse chicken breeds
M. O. Lee, M. N. Romanov, K. V. Plemyashov, N. V. Dementieva, O. V. Mitrofanova, O. Y. Barkova and J. E. Womack
Version of Record online: 5 APR 2017 | DOI: 10.1111/age.12552
- A novel splice mutation within equine KIT and the W15 allele in the homozygous state lead to all white coat color phenotypes
Heather M. Holl, Samantha A. Brooks, Meredith L. Carpenter, Carlos D. Bustamante and Christa Lafayette
Version of Record online: 5 APR 2017 | DOI: 10.1111/age.12554