British Journal of Clinical Pharmacology

Cover image for Vol. 84 Issue 1

Edited By: Professor Adam F Cohen

Impact Factor: 3.493

ISI Journal Citation Reports © Ranking: 2016: 60/257 (Pharmacology & Pharmacy)

Online ISSN: 1365-2125

Associated Title(s): British Journal of Pharmacology, Pharmacology Research & Perspectives

Editors' Choice - Volume 84, Issue 1

  • Pharmacokinetic interactions and dosing rationale for antiepileptic drugs in adults and children

    Pharmacokinetic interactions and dosing rationale for antiepileptic drugs in adults and children

    Simulated urinary uric acid (uUA) concentration and estimated pH for uric acid supersaturation, assuming a daily volume of urine of 15 dl. The simulated uUA concentration over time (left-hand panels) and the estimated pH at which this concentration would become supersaturated (right-hand panels). Imperfect adherence is modelled as an 8-day drug holiday (beginning on day 33). The shaded area represents the normal range for urine pH. The upper plots are the central estimates from the pharmacokinetic–pharmacodynamic model for a gout patient with hyperuricaemia from a reduced rate of uric acid clearance, and the lower plots for hyperuricaemia due to overproduction of xanthine. The urate lowering therapies used in these simulations were febuxostat 80 mg and lesinurad 200 mg, both once daily

  • Global population pharmacokinetics of the investigational Aurora A kinase inhibitor alisertib in cancer patients: rationale for lower dosage in Asia

    Global population pharmacokinetics of the investigational Aurora A kinase inhibitor alisertib in cancer patients: rationale for lower dosage in Asia

    Effects of region and race on alisertib apparent clearance (CL/F) based on the updated final model (analysis and validation data sets combined). (A) Box plots of CL/F distributions by region and race. (B) Box plots of CL/F distributions by race. The ‘West (Asian)’ category in (A) and ‘Asian – West’ category in (B) refer to the eight patients in the data set that were of Asian race in the Western region

  • Pharmacokinetic interactions and dosing rationale for antiepileptic drugs in adults and children
  • Global population pharmacokinetics of the investigational Aurora A kinase inhibitor alisertib in cancer patients: rationale for lower dosage in Asia

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