British Journal of Clinical Pharmacology

Cover image for Vol. 83 Issue 4

Editor in Chief: A.F. Cohen

Impact Factor: 3.83

ISI Journal Citation Reports © Ranking: 2015: 49/255 (Pharmacology & Pharmacy)

Online ISSN: 1365-2125

Associated Title(s): British Journal of Pharmacology, Pharmacology Research & Perspectives

Editors' Choice - Volume 83, Issue 3

  • The variability in beta-cell function in placebo-treated subjects with type 2 diabetes: application of the weight-HbA1c-insulin-glucose (WHIG) model

    The variability in beta-cell function in placebo-treated subjects with type 2 diabetes: application of the weight-HbA1c-insulin-glucose (WHIG) model

    The disposition index of subjects grouped by their diabetes duration. A robust loess smooth curve was plotted, with a 95% confidence interval around the mean

  • The variability in beta-cell function in placebo-treated subjects with type 2 diabetes: application of the weight-HbA1c-insulin-glucose (WHIG) model

    The variability in beta-cell function in placebo-treated subjects with type 2 diabetes: application of the weight-HbA1c-insulin-glucose (WHIG) model

    Visual predictive checks of the observations of weight, fasting serum insulin (FSI), fasting plasma glucose (FPG) and glycosylated haemoglobin (HbA1c) stratified by study. The shaded areas are the 95% confidence intervals of the 10th, 50th and 90th percentiles of the simulated concentrations. The dotted lines are the 10th and 90th percentiles from the observations and the solid line is the 50th percentile of the observations. The dots are the observations

  • The effect of renal dysfunction and haemodialysis on circulating liver specific miR-122

    The effect of renal dysfunction and haemodialysis on circulating liver specific miR‐122

    miR-122 is stable in plasma. Plasma samples were collected from healthy volunteers (n = 3) and immediately centrifuged to isolate plasma. One plasma sample was stored at −80°C without delay and the remaining tubes were left at room temperature (RT) or 4°C for 24 h or 7 days. Data presented as a Tukey plot

  • The effect of renal dysfunction and haemodialysis on circulating liver specific miR-122

    The effect of renal dysfunction and haemodialysis on circulating liver specific miR‐122

    Total circulating microRNA is lower in chronic kidney disease (CKD) stage IV. microRNA in plasma was quantified by Agilent 2100 Bioanalyzer. Patient groups were healthy controls (n = 17), CKD (n = 20), and end-stage renal disease immediately before and after haemodialysis (pre-HD and post-HD, respectively, both n = 17)

  • The variability in beta-cell function in placebo-treated subjects with type 2 diabetes: application of the weight-HbA1c-insulin-glucose (WHIG) model
  • The variability in beta-cell function in placebo-treated subjects with type 2 diabetes: application of the weight-HbA1c-insulin-glucose (WHIG) model
  • The effect of renal dysfunction and haemodialysis on circulating liver specific miR‐122
  • The effect of renal dysfunction and haemodialysis on circulating liver specific miR‐122

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