British Journal of Clinical Pharmacology

© The British Pharmacological Society

Cover image for Vol. 73 Issue 3

Accepted Articles (Accepted, unedited articles published online for future issues)

Edited By: J.M. Ritter (Editor-in-Chief), A. Cohen (European Editor), Y.K. Loke (European Editor), A. Somogyi (Australasian Editor), L.D. Lewis (American Editor), and A. Ferro (Reviews Editor)

Impact Factor: 3.063

ISI Journal Citation Reports © Ranking: 2010: 74/249 (Pharmacology & Pharmacy)

Online ISSN: 1365-2125

Associated Title(s): British Journal of Pharmacology

  1. Pharmacokinetics(PK)

    1. Population Pharmacokinetics of Mycophenolic Acid and Dose Optimisation with Limited Sampling Strategy in Liver Transplant Children

      Caroline Barau, Valérie Furlan, Dominique Debray, Anne-Marie Taburet and Aurélie Barrail-Tran

      Accepted manuscript online: 13 FEB 2012 09:30AM EST | DOI: 10.1111/j.1365-2125.2012.04213.x

  2. Book Reviews

    1. Facilitating Learning in Healthcare

      David Williams

      Accepted manuscript online: 9 FEB 2012 10:57AM EST | DOI: 10.1111/j.1365-2125.2012.04215.x

  3. Pharmacodynamics(PD)

    1. Investigation of the haemodynamic effects of exenatide in healthy male subjects

      B Mendis, E Simpson, I MacDonald and P Mansell

      Accepted manuscript online: 9 FEB 2012 10:57AM EST | DOI: 10.1111/j.1365-2125.2012.04214.x

  4. Meta-analysis

    1. Towards the identification of blood biomarkers for acute stroke in humans: a comprehensive systematic review

      Nazeeha Hasan, Peter McColgan, Paul Bentley, Robert J Edwards and Pankaj Sharma

      Accepted manuscript online: 9 FEB 2012 10:55AM EST | DOI: 10.1111/j.1365-2125.2012.04212.x

  5. Review

    1. Therapeutic strategies to deplete macrophages in atherosclerotic plaques

      Inge De Meyer, Wim Martinet and Guido R.Y. De Meyer

      Accepted manuscript online: 6 FEB 2012 03:32PM EST | DOI: 10.1111/j.1365-2125.2012.04211.x

  6. Pharmacokinetics (PK)

    1. Urinary pharmacokinetic methodology to determine the relative lung bioavailability of inhaled beclometasone

      Amira Ahmed, Lindsay P Harding and Henry Chrystyn

      Accepted manuscript online: 2 FEB 2012 09:49AM EST | DOI: 10.1111/j.1365-2125.2012.04210.x

    2. Effect of Ethinyl estradiol/ Levonorgestrel combined oral contraceptive on the activity of Cytochrome P4503A in obese women.

      Alison Edelman, Myrna Munar, Miriam R. Elman, Dennis Koop and Ganesh Cherala

      Accepted manuscript online: 2 FEB 2012 09:46AM EST | DOI: 10.1111/j.1365-2125.2012.04209.x

  7. Methods in clinical pharmacology

    1. Disease Progress and Response to Treatment as Predictors of Survival, Disability, Cognitive Impairment, and Depression in Parkinson's Disease

      Thuy C. Vu, John G. Nutt and Nicholas HG Holford

      Accepted manuscript online: 2 FEB 2012 09:44AM EST | DOI: 10.1111/j.1365-2125.2012.04208.x

  8. Pharmacokinetics (PK)

    1. The pharmacokinetics of oxypurinol in people with gout

      Sophie L Stocker, Andrew J McLachlan, Radojka M Savic, Carl M Kirkpatrick, Garry G Graham, Kenneth M Williams and Richard O Day

      Accepted manuscript online: 2 FEB 2012 09:39AM EST | DOI: 10.1111/j.1365-2125.2012.04207.x

  9. Paediatric clinical pharmacology

    1. Scaling of pharmacokinetics across paediatric populations: the lack of interpolative power of allometric models

      M Cella, C Knibbe, S N de Wildt, J Van Gerven, M Danhof and O Della Pasqua

      Accepted manuscript online: 2 FEB 2012 09:38AM EST | DOI: 10.1111/j.1365-2125.2012.04206.x

  10. Pharmacokinetics (PK)

    1. Integration of data from multiple sources for simultaneous modelling analysis: experience from nevirapine population pharmacokinetics

      Elin Svensson, Jan-Stefan van der Walt, Karen I Barnes, Karen Cohen, Tamara Kredo, Alwin Huitema, Jean B Nachega, Mats O Karlsson and Paolo Denti

      Accepted manuscript online: 2 FEB 2012 09:38AM EST | DOI: 10.1111/j.1365-2125.2012.04205.x

  11. Review

    1. Educating non-medical prescribers

      Derek Stewart, Katie MacLure and Johnson George

      Accepted manuscript online: 2 FEB 2012 09:38AM EST | DOI: 10.1111/j.1365-2125.2012.04204.x

    2. Does It Matter Where We Measure Blood Pressure?

      LA Tomlinson and IB Wilkinson

      Accepted manuscript online: 2 FEB 2012 09:38AM EST | DOI: 10.1111/j.1365-2125.2012.04203.x

  12. Therapeutics

    1. NeuroD1 A45T and PAX4 R121W polymorphisms are associated with plasma glucose level of repaglinide monotherapy in Chinese patient with type 2 diabetes

      Zhi-Cheng Gong, Qiong Huang, Xing-Ping Dai, Guang-Hua Lei, Hong-Bin Lu, Ji-Ye Yin, Xiao-Jing Xu, Jian Qu, Qi Pei, Min Dong, Bo-Ting Zhou, Jie Shen, Gan Zhou, Hong-Hao Zhou and Zhao-Qian Liu

      Accepted manuscript online: 1 FEB 2012 12:55PM EST | DOI: 10.1111/j.1365-2125.2012.04202.x

  13. Review

    1. Intracerebroventricular opioids for intractable pain

      Robert B. Raffa and Joseph V. Pergolizzi Jr

      Accepted manuscript online: 1 FEB 2012 12:55PM EST | DOI: 10.1111/j.1365-2125.2012.04201.x

  14. Short Report

    1. Effects of genetic variation in the P2RX7 gene on pharmacodynamics of a P2X7 receptor antagonist: a prospective genotyping approach

      Simon M McHugh, Shilina Roman, Bill G Davis, Annelize Koch, Alison M Pickett, Jill C Richardson, Sam R Miller, Sally Wetten, Charles J Cox, Fredrik Karpe, John A Todd and Edward T Bullmore

      Accepted manuscript online: 1 FEB 2012 12:44PM EST | DOI: 10.1111/j.1365-2125.2012.04200.x

  15. letter

    1. Comparison of Serum and Lithium-Heparinate Plasma for the Accurate Measurements of Endogenous and Exogenous Morphine Concentrations

      Alexis Laux, Nadja Gräfe, Jinane Mouheiche, Denise Stuber, Ingeborg D. Welters, François Delalande, Pierrick Poisbeau, Patrick Garnero, Marie-Hélène Metz-Boutigue, Francis Schneider and Yannick Goumon

      Accepted manuscript online: 1 FEB 2012 12:43PM EST | DOI: 10.1111/j.1365-2125.2012.04199.x

  16. Pharmacokinetics (PK)

    1. Simultaneous Population Pharmacokinetic Modeling of Ketamine and Three Major Metabolites in Patients with Treatment-Resistant Bipolar Depression

      Xiaochen Zhao, Swarajya Lakshmi Vattem Venkata, Ruin Moaddel, Dave A. Luckenbaugh, Nancy E. Brutsche, Lobna Ibrahim, Carlos A. Zarate Jr, Donald E. Mager and Irving W. Wainer

      Accepted manuscript online: 1 FEB 2012 12:43PM EST | DOI: 10.1111/j.1365-2125.2012.04198.x

  17. PK-PD relationships

    1. Model-based treatment optimisation of a novel VEGFR-inhibitor

      Ron J Keizer, Anubha Gupta, Robert Shumaker, Jos H Beijnen, Jan HM Schellens and Alwin DR Huitema

      Accepted manuscript online: 1 FEB 2012 12:43PM EST | DOI: 10.1111/j.1365-2125.2012.04197.x

  18. Drug interactions

    1. Drug interaction profile for GSK2248761, a next-generation non-nucleoside reverse transcriptase inhibitor

      Steve Piscitelli, Joseph Kim, Elizabeth Gould, Yu Lou, Scott White, Mark de Serres, Mark Johnson, Xiao-Jian Zhou, Keith Pietropaolo and Douglas Mayers

      Accepted manuscript online: 30 JAN 2012 10:31PM EST | DOI: 10.1111/j.1365-2125.2012.04194.x

  19. Methods in clinical pharmacology

    1. You have full text access to this OnlineOpen article
      Cluster randomised trials of prescription medicines or prescribing policy– public and general practitioner opinions in Scotland

      Isla S Mackenzie, Li Wei, Kenneth R Paterson and Thomas M MacDonald

      Accepted manuscript online: 30 JAN 2012 10:31PM EST | DOI: 10.1111/j.1365-2125.2012.04195.x

  20. Reviews

    1. Prescribing and the core curriculum for tomorrow's doctors: BPS Curriculum in Clinical Pharmacology and Prescribing for Medical Students

      Sarah Ross and Simon Maxwell

      Accepted manuscript online: 30 JAN 2012 10:25PM EST | DOI: 10.1111/j.1365-2125.2012.04186.x

  21. PK-PD Relationships

    1. Progression of Motor and Non-Motor Features of Parkinson's Disease and Their Response to Treatment

      Thuy C. Vu, John G. Nutt and Nicholas HG Holford

      Accepted manuscript online: 29 JAN 2012 01:40AM EST | DOI: 10.1111/j.1365-2125.2012.04192.x

  22. Pharmacoepidemiology

    1. Non-Steroidal Anti-Inflammatory Drugs and The Risk of Clostridium Difficile-Associated Disease

      Daniel Suissa , Joseph A C Delaney, Sandra Dial and Paul Brassard

      Accepted manuscript online: 29 JAN 2012 01:37AM EST | DOI: 10.1111/j.1365-2125.2012.04191.x

  23. Clinical Trials

    1. Repeated supratherapeutic dosing of strontium ranelate 4g/d over 15 days does not prolong QTc interval in healthy volunteers

      Jorg Taubel, Asif Naseem, Duolao Wang, Radivoj Arezina, Ulrike Lorch and A. John Camm

      Accepted manuscript online: 29 JAN 2012 01:35AM EST | DOI: 10.1111/j.1365-2125.2012.04190.x

  24. Pharmacogenetics

    1. Effects of Angiotensin Receptor Blockers on Endothelial Nitric Oxide Release — The Role of eNOS Variants

      R. Preston Mason, Robert F. Jacob, Ruslan Kubant, Adam Jacoby, Febee Louka, J. Jose Corbalan and Tadeusz Malinski

      Accepted manuscript online: 29 JAN 2012 01:35AM EST | DOI: 10.1111/j.1365-2125.2012.04189.x

  25. Main Paper

    1. You have free access to this content
      Dose-response relationship between Selective Serotonin Reuptake Inhibitors and Injurious Falls: A study in Nursing Home Residents with Dementia

      Carolyn S. Sterke, Gijsbertus Ziere, Ed F. van Beeck, Caspar W. N. Looman and Tischa J. M. van der Cammen

      Accepted manuscript online: 18 JAN 2012 09:28PM EST | DOI: 10.1111/j.1365-2125.2012.04124.x

  26. Paediatric Clinical Pharmacology

    1. Adaptive trials in paediatric development: dealing with heterogeneity and uncertainty in pharmacokinetic differences in children

      Massimo Cella, Meindert Danhof and Oscar Della Pasqua

      Accepted manuscript online: 18 JAN 2012 10:56AM EST | DOI: 10.1111/j.1365-2125.2012.04187.x

  27. Short Reports

    1. Trends of reporting of “serious” versus “non-serious” Adverse Drug Reactions over time: a study in the French PharmacoVigilance Database

      Guillaume Moulis, Agnès Sommet, Geneviève Durrieu, Haleh Bagheri, Maryse Lapeyre-Mestre and Jean-Louis Montastruc, The French Association of PharmacoVigilance Centres.

      Accepted manuscript online: 18 JAN 2012 10:53AM EST | DOI: 10.1111/j.1365-2125.2012.04185.x

  28. Pharmacoepidemiology

    1. Influence of the drug exposure definition on the assessment of the antipsychotic metabolic impact in patients initially treated with mood-stabilizers

      Marie Tournier, Bernard Bégaud, Audrey Cougnard, Guy-Robert Auleley, Jean Deligne, Claudine Blum-Boisgard, Anne CM Thiébaut and Hélène Verdoux

      Accepted manuscript online: 18 JAN 2012 10:53AM EST | DOI: 10.1111/j.1365-2125.2012.04184.x

  29. Therapeutics

    1. Implementing a statin switching programme in primary care: Patients’ views and experiences

      Janet Krska, K Allison, M Delargy, L Murray and Hillary Smith

      Accepted manuscript online: 18 JAN 2012 10:50AM EST | DOI: 10.1111/j.1365-2125.2012.04183.x

  30. Review

    1. A NEW TAXONOMY FOR DESCRIBING AND DEFINING ADHERENCE TO MEDICATIONS

      B. Vrijens, S. De Geest, D. A. Hughes, P. Kardas, J. Demonceau, T. Ruppar, F. Dobbels, E. Fargher, V. Morrison, P. Lewek, M. Matyjaszczyk, C. Mshelia, W. Clyne, J.K. Aronson and J. Urquhart, ABC project team

      Accepted manuscript online: 16 JAN 2012 08:23AM EST | DOI: 10.1111/j.1365-2125.2011.04167.x

  31. Drug Interactions

    1. The Effects of Febuxostat on the Pharmacokinetic Parameters of Rosiglitazone, A CYP2C8 Substrate

      Himanshu Naik, Jing-tao Wu, Robert Palmer and Lachy McLean

      Accepted manuscript online: 13 JAN 2012 10:09AM EST | DOI: 10.1111/j.1365-2125.2012.04182.x

  32. Pharmacokinetics

    1. Population Pharmacokinetics and Pharmacodynamics of Rivaroxaban in Patients with Acute Coronary Syndromes

      X. S. Xu, K. Moore, P. Burton, K. Stuyckens, W. Mueck, S. Rossenu, A. Plotnikov, M. Gibson and A. Vermeulen

      Accepted manuscript online: 13 JAN 2012 10:09AM EST | DOI: 10.1111/j.1365-2125.2012.04181.x

  33. Systematic Reviews

    1. Medication Review and Reconciliation with Cooperation between Pharmacist and General Practitioner and the Benefit for the Patient: a Systematic Review

      Marlies M.E. Geurts, Jaap Talsma, Jacobus R.B.J. Brouwers and Johan J. de Gier

      Accepted manuscript online: 13 JAN 2012 09:55AM EST | DOI: 10.1111/j.1365-2125.2012.04178.x

  34. Letters

    1. Authors’ response to Hermann et al. Minimum quality criteria are needed in the assessment and communication of unexpected drug safety findings of marketed products from RCTs

      Koenraad Blot and Martin C. Michel

      Accepted manuscript online: 13 JAN 2012 09:54AM EST | DOI: 10.1111/j.1365-2125.2012.04180.x

  35. Reviews

    1. The use of tumour volumetrics to assess response to therapy in anti-cancer clinical trials

      Gregory V Goldmacher and James Conklin

      Accepted manuscript online: 13 JAN 2012 09:53AM EST | DOI: 10.1111/j.1365-2125.2012.04179.x

    2. Use of Dicarboxylic Acids in Type 2 Diabetes

      Geltrude Mingrone, Lidia Castagneto-Gissey and Katherine Macé

      Accepted manuscript online: 13 JAN 2012 09:49AM EST | DOI: 10.1111/j.1365-2125.2012.04177.x

  36. Pharmacodynamics

    1. Changes of Blood Endocannabinoids during Anaesthesia: a Special Case for Fatty Acid Amide Hydrolase Inhibition by Propofol?

      Carina Jarzimski, Matthias Karst, Alexander A. Zoerner, Christin Rakers, Marcus May, Maria T. Suchy, Dimitrios Tsikas, Joachim K. Krauss, Dirk Scheinichen, Jens Jordan and Stefan Engeli

      Accepted manuscript online: 13 JAN 2012 09:47AM EST | DOI: 10.1111/j.1365-2125.2012.04175.x

  37. Letters

    1. Minimum Quality Criteria are needed in the Assessment and Communication of Unexpected Drug Safety Findings of Marketed Products from RCTs

      Robert Hermann, Peter Cnota and Joachim Maus

      Accepted manuscript online: 13 JAN 2012 09:45AM EST | DOI: 10.1111/j.1365-2125.2012.04176.x

  38. Pharmacokinetics

    1. Pharmacokinetics of linagliptin in subjects with hepatic impairment

      Ulrike Graefe-Mody, Peter Rose, Silke Retlich, Arne Ring, Lisa Waldhauser, Rodica Cinca and Hans-Juergen Woerle

      Accepted manuscript online: 13 JAN 2012 09:44AM EST | DOI: 10.1111/j.1365-2125.2012.04173.x

    2. Bioequivalence of Two Omega-3 Fatty Acid Ethyl Ester Formulations: a Case of Clinical Pharmacology of Dietary Supplements

      C. Galli, F.M. Maggi, P.Gian Marco Risé and C.R. Sirtori

      Accepted manuscript online: 13 JAN 2012 09:44AM EST | DOI: 10.1111/j.1365-2125.2012.04174.x

    3. Pharmacokinetic Predictions for Patients with Renal Impairment: Focus on Peptides and Protein Drugs.

      David Czock, Frieder Keller and Hanna Seidling

      Accepted manuscript online: 13 JAN 2012 09:43AM EST | DOI: 10.1111/j.1365-2125.2012.04172.x

  39. Drug Interactions

    1. Lack of a Meaningful Effect of Anacetrapib on the Pharmacokinetics and Pharmacodynamics of Warfarin in Healthy Subjects

      Rajesh Krishna, Daria Stypinski, Melissa Ali, Amit Garg, Josee Cote, Andrea Maes, Bruce DeGroot, Yang Liu, Susie Li, Sandra M. Connolly, John A. Wagner and S. Aubrey Stoch

      Accepted manuscript online: 13 JAN 2012 09:40AM EST | DOI: 10.1111/j.1365-2125.2012.04171.x

  40. Pharmacoepidemiology

    1. Long-term use of drugs affecting the renin-angiotensin system and the risk of cancer. A population-based case-control study.

      Jesper Hallas, Rene dePont Christensen, Morten Andersen, Søren Friis and Lars Bjerrum

      Accepted manuscript online: 13 JAN 2012 09:40AM EST | DOI: 10.1111/j.1365-2125.2012.04170.x

  41. Drug Interactions

    1. Concomitant use of clopidogrel and statins and risk of major adverse cardiovascular events following coronary stent implantation

      Morten Schmidt, Martin B. Johansen, Michael Maeng, Anne Kaltoft, Lisette O. Jensen, Hans-Henrik Tilsted, Hans E. Bøtker, John A. Baron and Henrik Toft Sørensen

      Accepted manuscript online: 13 JAN 2012 09:40AM EST | DOI: 10.1111/j.1365-2125.2012.04169.x

  42. Drug interactions

    1. You have full text access to this OnlineOpen article
      Lack of Effect of Tofacitinib (Cp 690,550) on The Pharmacokinetics of Cyp3a4 Substrate Midazolam in Healthy Volunteers: Confirmation of in Vitro Data

      Pankaj Gupta, Christine. Alvey, Rong Wang, Martin E. Dowty, Odette A. Fahmi, Robert L. Walsky, Richard J. Riese and Sriram Krishnaswami

      Accepted manuscript online: 11 JAN 2012 01:30AM EST | DOI: 10.1111/j.1365-2125.2012.04168.x

  43. Drug Safety

    1. Novel Δ9-tetrahydrocannabinol formulation Namisol® has beneficial pharmacokinetics and promising pharmacodynamic effects

      Linda E. Klumpers, Tim L. Beumer, Johan G.C. van Hasselt, Astrid Lipplaa, Lennard B. Karger, H. Daniël Kleinloog, Jan I. Freijer, Marieke L. de Kam and Joop M.A. van Gerven

      Accepted manuscript online: 28 DEC 2011 03:14PM EST | DOI: 10.1111/j.1365-2125.2011.04164.x

  44. Review

    1. A review of medication incidents reported to the National Reporting and Learning System in England and Wales over six years (2005 – 2010)

      DH Cousins, D Gerrett and B Warner

      Accepted manuscript online: 22 DEC 2011 02:25AM EST | DOI: 10.1111/j.1365-2125.2011.04166.x

  45. Short Report

    1. Pilot Study of Rosiglitazone as an in vivo Probe of Paclitaxel Exposure

      Daniel L Hertz, Christine M Walko, Arlene S Bridges, J. Heyward Hull, Jill Herendeen, Kristan Rollins, Paul B Watkins and E. Claire Dees

      Accepted manuscript online: 22 DEC 2011 02:25AM EST | DOI: 10.1111/j.1365-2125.2011.04165.x

  46. Pharmacogenetics

    1. Influence of CYP2B6 and ABCB1 SNPs on Nevirapine Plasma Concentrations in Burundese HIV-positive Patients Using Dried Sample Spot Devices

      A Calcagno, A D'Avolio, M Simiele, J Cusato, R Rostagno, V Libanore, L Baietto, M Siccardi, S Bonora and G Di Perri

      Accepted manuscript online: 22 DEC 2011 02:25AM EST | DOI: 10.1111/j.1365-2125.2011.04163.x

  47. Pharmacoepidemiology

    1. The impact of antibiotic use on the incidence and resistance pattern of ESBL-producing bacteria in primary and secondary healthcare settings

      Mamoon A. Aldeyab, Stephan Harbarth, Nathalie Vernaz, Mary P. Kearney, Michael G. Scott, Feras W. Darwish Elhajji, Motasem A. Aldiab and James C. McElnay

      Accepted manuscript online: 9 DEC 2011 12:40AM EST | DOI: 10.1111/j.1365-2125.2011.04161.x

  48. Obituary

    1. David Grahame Grahame-Smith : Clinical pharmacologist 1933-2011

      Jeffrey K Aronson

      Accepted manuscript online: 6 DEC 2011 01:20AM EST | DOI: 10.1111/j.1365-2125.2011.04160.x

  49. Review

    1. Therapeutic drug monitoring to adjust dosing in morbid obesity – a new use for an old methodology

      Jennifer H. Martin, Mohamed Saleem and David Looke

      Accepted manuscript online: 1 DEC 2011 04:06AM EST | DOI: 10.1111/j.1365-2125.2011.04159.x

  50. Pharmacokinetics (PK)

    1. Model-based approach to dose optimization of lopinavir/ritonavir when co-administered with rifampicin

      Chao Zhang, Paolo Denti, Eric Decloedt, Gary Maartens, Mats O Karlsson, Ulrika SH Simonsson and Helen McIlleron

      Accepted manuscript online: 30 NOV 2011 01:37AM EST | DOI: 10.1111/j.1365-2125.2011.04154.x

  51. Letter

    1. Severe coagulopathy caused by rifampicin in patients with primary sclerosing cholangitis and refractory pruritus

      Fotios Sampaziotis and William JH Griffiths

      Accepted manuscript online: 29 NOV 2011 07:15AM EST | DOI: 10.1111/j.1365-2125.2011.04158.x

  52. Human Toxicology

    1. Correlation of paired toxic plasma and saliva paracetamol concentrations following deliberate self-poisoning with paracetamol

      J H Soderstrom, D M Fatovich, C Mandelt, S Vasikaran, D L McCoubrie, F F Daly and S A Burrows

      Accepted manuscript online: 29 NOV 2011 07:15AM EST | DOI: 10.1111/j.1365-2125.2011.04157.x

  53. Letter

    1. A case report of voriconazole therapy failure in a homozygous ultrarapid CYP2C19*17/*17 patient comedicated with carbamazepine

      Mirte M. Malingré, Peggy C.R. Godschalk and Saskia K. Klein

      Accepted manuscript online: 29 NOV 2011 07:15AM EST | DOI: 10.1111/j.1365-2125.2011.04156.x

  54. Drug Interactions

    1. A clinical study to assess CYP1A2 and CYP3A4 induction by AZD7325, a selective GABAA receptor modulator – an in vitro and in vivo comparison

      Diansong Zhou, Maria Sunzel, Maria D. Ribadeneira, Mark A. Smith, Dhaval Desai, Jianrong Lin and Scott W. Grimm

      Accepted manuscript online: 29 NOV 2011 07:15AM EST | DOI: 10.1111/j.1365-2125.2011.04155.x

  55. Review

    1. Using text-mining techniques in electronic patient records to identify ADRs from medicine use

      Pernille Warrer, Ebba Holme Hansen, Lars Juhl-Jensen and Lise Aagaard

      Accepted manuscript online: 29 NOV 2011 07:15AM EST | DOI: 10.1111/j.1365-2125.2011.04153.x

    2. Assessing prescribing competence

      John Mucklow, Lynne Bollington and Simon Maxwell

      Accepted manuscript online: 24 NOV 2011 09:56AM EST | DOI: 10.1111/j.1365-2125.2011.04151.x

  56. Drug Interactions

    1. Inhibition of organic anion-transporting polypeptide 1B1 by quercetin: an in vitro and in vivo assessment

      Lan-Xiang Wu, Cheng-Xian Guo, Wang-Qing Chen, Jing Yu, Qiang Qu, Yao Chen, Zhi-Rong Tan, Guo Wang, Lan Fan, Qing Li, Wei Zhang and Hong-Hao Zhou

      Accepted manuscript online: 24 NOV 2011 09:56AM EST | DOI: 10.1111/j.1365-2125.2011.04150.x

  57. PK-PD Relationships

    1. The pharmacokinetics and pharmacodynamics of cisatracurium in critically ill patients with severe sepsis

      Xin Liu, Peter S. Kruger, Michael Weiss and Michael S. Roberts

      Accepted manuscript online: 24 NOV 2011 09:55AM EST | DOI: 10.1111/j.1365-2125.2011.04149.x

  58. Letter

    1. Oxypurinol, allopurinol and allopurinol-1-riboside in plasma following an acute overdose of allopurinol in a patient with advanced chronic kidney disease

      Diluk R.W. Kannangara, Darren M. Roberts, Timothy J. Furlong, Garry G. Graham, Kenneth M. Williams and Richard O. Day

      Accepted manuscript online: 18 NOV 2011 07:30AM EST | DOI: 10.1111/j.1365-2125.2011.04147.x

  59. Drug Metabolism

    1. Methadone Inhibits CYP2D6 and UGT2B7/2B4 in vivo: a study using codeine in methadone and buprenorphine maintained subjects

      Eloise A. Gelston, Janet K. Coller, Olga V. Lopatko, Heather M. James, Helmut Schmidt, Jason M. White and Andrew A. Somogyi

      Accepted manuscript online: 17 NOV 2011 10:13PM EST | DOI: 10.1111/j.1365-2125.2011.04145.x

  60. Pharmacoepidemiology

    1. You have full text access to this OnlineOpen article
      Influenza H1N1 (swine flu) vaccination: a safety surveillance feasibility study using self-reporting of serious adverse events and pregnancy outcomes

      Isla S Mackenzie, Thomas M MacDonald, Saad Shakir, Moira Dryburgh, Brian J Mantay, Patrick McDonnell and Deborah Layton

      Accepted manuscript online: 15 NOV 2011 02:08AM EST | DOI: 10.1111/j.1365-2125.2011.04142.x

  61. Clinical Trials

    1. Effects of Hydrocortisone on Acute Beta-Blocker and Histamine Induced Bronchoconstriction

      Philip M Short, Peter A Williamson and Brian J Lipworth

      Accepted manuscript online: 14 NOV 2011 03:58AM EST | DOI: 10.1111/j.1365-2125.2011.04143.x

  62. Pharmacogenetics

    1. Multifactorial pharmacogenetic analysis in colorectal cancer patients receiving 5FU-based therapy together with cetuximab-irinotecan

      Marie-Christine ETIENNE-GRIMALDI, Jaafar BENNOUNA, Jean-Louis FORMENTO, Jean-Yves DOUILLARD, Mireille FRANCOUAL, Isabelle HENNEBELLE, Etienne CHATELUT, Eric FRANCOIS, Roger FAROUX, Chaza EL HANNANI, Jacques-Henri JACOB and Gérard MILANO

      Accepted manuscript online: 7 NOV 2011 03:55AM EST | DOI: 10.1111/j.1365-2125.2011.04141.x

  63. Pharmacokinetics (PK)

    1. Development of Population PK Model with Enterohepatic Circulation for Mycophenolic Acid in Patients with Childhood-onset Systemic Lupus Erythematosus

      Catherine M. T. Sherwin, Anna Carmela P. Sagcal-Gironella, Tsuyoshi Fukuda, Hermine I. Brunner and Alexander A. Vinks

      Accepted manuscript online: 7 NOV 2011 03:55AM EST | DOI: 10.1111/j.1365-2125.2011.04140.x

  64. Review

    1. You have full text access to this OnlineOpen article
      Pleiotropic effects of pitavastatin

      Jean Davignon OC

      Accepted manuscript online: 7 NOV 2011 03:55AM EST | DOI: 10.1111/j.1365-2125.2011.04139.x

  65. Short Report

    1. Unexpected frequent hepatotoxicity of a prescription drug, flupirtine, marketed for about 30 years

      Martin C. Michel, Piotr Radziszewski, Christian Falconer, Daniela Marschall-Kehrel and Koenraad Blot

      Accepted manuscript online: 2 NOV 2011 04:02AM EST | DOI: 10.1111/j.1365-2125.2011.04138.x

  66. Clinical Trials

    1. Assessment of the pharmacology and tolerability of PF-04457845, an irreversible inhibitor of fatty acid amide hydrolase-1, in healthy subjects

      Gai Ling Li, Helen Winter, Rosalin Arends, Gary W Jay, Vu Le, Tim Young and John P Huggins

      Accepted manuscript online: 1 NOV 2011 11:58PM EST | DOI: 10.1111/j.1365-2125.2011.04137.x

  67. Pharmacokinetics (PK)

    1. EFFECTS OF KETOCONAZOLE AND VALPROIC ACID ON THE PHARMACOKINETICS OF THE NEXT-GENERATION NNRTI LERSIVIRINE (UK-453,061) IN HEALTHY ADULT SUBJECTS

      G Langdon, J Davis, G Layton, CL Chong, G Weissgerber and M Vourvahis

      Accepted manuscript online: 1 NOV 2011 01:20AM EST | DOI: 10.1111/j.1365-2125.2011.04136.x

  68. Drug Safety

    1. Adulteration of herbal antidiabetic products with undeclared pharmaceuticals: a case series in Hong Kong

      Dr C K CHING, Mr Y H LAM, Dr Albert Y W CHAN and Dr Tony W L MAK

      Accepted manuscript online: 28 OCT 2011 08:55AM EST | DOI: 10.1111/j.1365-2125.2011.04135.x

  69. Review

    1. New pharmacological strategies for treatment of Alzheimer's disease: focus on disease-modifying drugs

      Salvatore Salomone, Filippo Caraci, Gian Marco Leggio, Julia Fedotova and Filippo Drago

      Accepted manuscript online: 28 OCT 2011 08:55AM EST | DOI: 10.1111/j.1365-2125.2011.04134.x

  70. Short Report

    1. A cross sectional survey of the views of newly registered pharmacists in Great Britain on their potential prescribing role: a cautious approach

      Trudi McIntosh, Kim Munro, James McLay and Derek Stewart

      Accepted manuscript online: 28 OCT 2011 08:55AM EST | DOI: 10.1111/j.1365-2125.2011.04133.x

  71. Pharmacogenetics

    1. Interaction analysis between genetic polymorphisms and pharmacodynamic effect in patients treated with adjunctive cilostazol to dual antiplatelet therapy : Results of the ACCEL-TRIPLE (Accelerated Platelet Inhibition by Triple Antiplatelet Therapy According to Gene Polymorphism) study

      In-Suk Kim, Young-Hoon Jeong, Yongwhi Park, Seong-Eun Yoon, Tae Jung Kwon, Jeong Rang Park, Seok-Jae Hwang, Eun-Ha Koh, Choong Hwan Kwak, Jin-Yong Hwang and Sunjoo Kim

      Accepted manuscript online: 18 OCT 2011 11:37PM EST | DOI: 10.1111/j.1365-2125.2011.04131.x

  72. Short Report

    1. Association between BclI polymorphism in the NR3C1 gene and in vitro individual variations in lymphocyte-responses to methylprednisolone

      E. Cuzzoni, S. De Iudicibus, F. Bartoli, A. Ventura and G. Decorti

      Accepted manuscript online: 18 OCT 2011 11:36PM EST | DOI: 10.1111/j.1365-2125.2011.04130.x

  73. Translational Research

    1. Pulse pressure amplification in relation to body fatness

      Andrzej Wykretowicz, Agnieszka Rutkowska, Tomasz Krauze, Dagmara Przymuszala, Przemyslaw Guzik, Ryszard Marciniak and Henryk Wysocki

      Accepted manuscript online: 18 OCT 2011 07:07AM EST | DOI: 10.1111/j.1365-2125.2011.04129.x

  74. Pharmacokinetics (PK)

    1. Convective transport of highly plasma protein bound drugs facilitates direct penetration into deep tissues after topical application

      Yuri Dancik, Yuri G. Anissimov, Owen G. Jepps and Michael S. Roberts

      Accepted manuscript online: 14 OCT 2011 07:37AM EST | DOI: 10.1111/j.1365-2125.2011.04128.x

  75. Pharmacogenetics

    1. Influence of ABCB1 (P-glycoprotein) haplotypes on nortriptyline pharmacokinetics and nortriptyline-induced postural hypotension in healthy volunteers

      Berit Packert Jensen, Rebecca Lee Roberts, Ritva Vyas, Gitte Bonke, David L Jardine and Evan James Begg

      Accepted manuscript online: 14 OCT 2011 07:37AM EST | DOI: 10.1111/j.1365-2125.2011.04126.x

  76. PK-PD Relationships

    1. Model-based design of rituximab dosage optimisation in follicular non-Hodgkin's lymphoma

      David Ternant, Guillaume Cartron, Emilie Hénin, Michel Tod, Pascal Girard and Gilles Paintaud

      Accepted manuscript online: 14 OCT 2011 07:37AM EST | DOI: 10.1111/j.1365-2125.2011.04125.x

  77. Pharmacogenetics

    1. Influence of SLCO1B3 Haplotype-tag SNPs on Docetaxel Disposition in Chinese Nasopharyngeal Cancer Patients

      Sin-Chi Chew, Edwin Sandanaraj, Onkar Singh, Xiangai Chen, Eng-Huat Tan, Wan-Teck Lim, Edmund-JD Lee and Balram Chowbay

      Accepted manuscript online: 13 OCT 2011 09:30AM EST | DOI: 10.1111/j.1365-2125.2011.04123.x

  78. Paediatric Clinical Pharmacology

    1. Population pharmacokinetics and maximum a posteriori probability Bayesian estimator of abacavir: application of individualized therapy in HIV infected infants and toddlers

      W Zhao, M Cella, O Della Pasqua, D Burger and E Jacqz-Aigrain, on behalf of Pediatric European Network for Treatment of AIDS (PENTA) 15 study group

      Accepted manuscript online: 11 OCT 2011 09:00AM EST | DOI: 10.1111/j.1365-2125.2011.04121.x

  79. Clinical Trials

    1. Calcineurin inhibitors acutely improve insulin sensitivity without affecting insulin secretion in healthy human volunteers

      Lara Aygen Øzbay, Niels Møller, Claus Juhl, Mette Bjerre, Jan Carstens, Jørgen Rungby and Kaj Anker Jørgensen

      Accepted manuscript online: 11 OCT 2011 08:57AM EST | DOI: 10.1111/j.1365-2125.2011.04118.x

  80. PK-PD Relationships

    1. Ceftazidime dosage regimen in ICU patients: From a population pharmacokinetic approach to clinical practice via Monte Carlo simulations

      Bernard Georges, Jean-Marie Conil, Stéphanie Ruiz, Thierry Seguin, Pierre Cougot, Olivier Fourcade, Georges Houin and Sylvie Saivin

      Accepted manuscript online: 11 OCT 2011 08:57AM EST | DOI: 10.1111/j.1365-2125.2011.04117.x

  81. Pharmacokinetics (PK)

    1. Population pharmacokinetics of ciclosporin in haematopoietic allogeneic stem cell transplantation with emphasis on limited sampling strategy

      Abraham J. Wilhelm, Peer de Graaf, Agnes I. Veldkamp, Jeroen J.W.M. Janssen, Peter C. Huijgens and Eleonora L. Swart

      Accepted manuscript online: 11 OCT 2011 08:56AM EST | DOI: 10.1111/j.1365-2125.2011.04116.x

  82. PK-PD Relationships

    1. Effects of CYP3A4 inhibition and induction on the pharmacokinetics and pharmacodynamics of tolvaptan a non-peptide AVP antagonist in healthy subjects

      Susan E. Shoaf, Patricia Bricmont and Suresh Mallikaarjun

      Accepted manuscript online: 11 OCT 2011 08:56AM EST | DOI: 10.1111/j.1365-2125.2011.04114.x

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