British Journal of Clinical Pharmacology

Cover image for Vol. 81 Issue 5

Accepted Articles (Accepted, unedited articles published online and citable. The final edited and typeset version of record will appear in future.)

Edited By: A.F. Cohen (Editor-in-Chief), A. de Boer (European Editor), A. Ferro (Reviews Editor), A. Gilchrist (Online Editor), G. Isbister (Australasian Editor), S. Ross (Education Editor) and A. Webb (European Editor)

Impact Factor: 3.878

ISI Journal Citation Reports © Ranking: 2014: 46/255 (Pharmacology & Pharmacy)

Online ISSN: 1365-2125

Associated Title(s): British Journal of Pharmacology, Pharmacology Research & Perspectives


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  1. Pharmacokinetics

    1. Salivary Caffeine Concentrations are Comparable to Plasma Concentrations in Preterm Infants Receiving Extended Caffeine Therapy

      N. R. Dobson, X. Liu, L. M. Rhein, R. A. Darnall, M. J. Corwin, B. L. McEntire, R. M. Ward, L. P. James, C. M. T. Sherwin, T. C. Heeren and C. E. Hunt

      Accepted manuscript online: 4 MAY 2016 04:00PM EST | DOI: 10.1111/bcp.13001

  2. Pharmacoepidemiology

    1. Prescribing Trends of Attention-Deficit Hyperactivity Disorder (ADHD) Medications in UK Primary Care, 1995-2015

      Christel Renoux, Ju-Young Shin, Sophie Dell'Aniello, Emma Fergusson and Samy Suissa

      Accepted manuscript online: 4 MAY 2016 02:31PM EST | DOI: 10.1111/bcp.13000

  3. Pharmacokinetics

    1. Model-based evaluation of pulmonary pharmacokinetics in asthmatic and COPD patients after oral olodaterol inhalation

      Jens Markus Borghardt, Benjamin Weber, Alexander Staab, Christina Kunz and Charlotte Kloft

      Accepted manuscript online: 4 MAY 2016 01:30PM EST | DOI: 10.1111/bcp.12999

  4. Methods in Clinical Pharmacology

  5. Pharmacokinetic Dynamic Relationships

    1. R-and S-citalopram concentrations have differential effects on neuropsychiatric scores in elders with dementia and agitation

      T. Ho, B. G. Pollock, B. H. Mulsant, O. Schantz, D. P. Devanand, J. E. Mintzer, A. P. Porsteinsson, L. S. Schneider, D. Weintraub, J. Yesavage, L. T. Drye, C. A. Munro, D. M. Shade, C. Lyketsos and R. Bies

      Accepted manuscript online: 4 MAY 2016 11:31AM EST | DOI: 10.1111/bcp.12997

  6. Reviews

    1. Cell membranes… and how long drugs may exert beneficial pharmacological activity in vivo.

      Georges Vauquelin

      Accepted manuscript online: 2 MAY 2016 05:30AM EST | DOI: 10.1111/bcp.12996

  7. Pharmacoepidemiologies

    1. Potentially inappropriate prescribing according to STOPP and START and adverse outcomes in community-dwelling older people: a prospective cohort study

      Frank Moriarty, Kathleen Bennett, Caitriona Cahir, Rose Anne Kenny and Tom Fahey

      Accepted manuscript online: 2 MAY 2016 05:18AM EST | DOI: 10.1111/bcp.12995

  8. Pharmacokinetic Dynamic Relationships

    1. Models for change in tumour size, appearance of new lesions and survival probability in patients with advanced epithelial ovarian cancer

      Chiara Zecchin, Ivelina Gueorguieva, Nathan H. Enas and Lena E. Friberg

      Accepted manuscript online: 2 MAY 2016 04:45AM EST | DOI: 10.1111/bcp.12994

  9. Drugs in Pregnancy and Lactation

    1. Population Pharmacokinetics of 17α-hydroxyprogesterone caproate in singleton gestation

      Shringi Sharma, Steve Caritis, Gary Hankins, Menachem Miodovnik, Mary F. Hebert, Don Mattison and Raman Venkatramanan

      Accepted manuscript online: 2 MAY 2016 12:10AM EST | DOI: 10.1111/bcp.12990

  10. Review Themed Issue

    1. Oleuropein aglycone and polyphenols from olive mill wastewater ameliorate cognitive deficits and neuropathology

      Daniela Pantano, Ilaria Luccarini, Pamela Nardiello, Maurizio Servili, Massimo Stefani and Fiorella Casamenti

      Accepted manuscript online: 30 APR 2016 10:08AM EST | DOI: 10.1111/bcp.12993

  11. Clinical Trials

    1. Pharmacokinetic-pharmacodynamic modeling of acute N-terminal pro B-type natriuretic peptide after doxorubicin infusion in breast cancer

      Shuang Liang, Richard C. Brundage, Pamala A. Jacobson, Anne Blaes and Mark N. Kirstein

      Accepted manuscript online: 29 APR 2016 11:15AM EST | DOI: 10.1111/bcp.12989

  12. Pharmacokinetics

    1. Pharmacokinetics of ixazomib, an oral proteasome inhibitor, in solid tumour patients with moderate or severe hepatic impairment

      N. Gupta, M. J. Hanley, K. Venkatakrishnan, R. Perez, R. E. Norris, J. Nemunaitis, H. Yang, M. G. Qian, G. Falchook, R. Labotka and S. Fu

      Accepted manuscript online: 28 APR 2016 03:30AM EST | DOI: 10.1111/bcp.12991

  13. Clinical Trials

    1. Brentuximab vedotin, an antibody-drug conjugate, in patients with CD30-positive haematologic malignancies and hepatic or renal impairment

      B. Zhao, R. Chen, O. A. O'Connor, A. K. Gopal, R. Ramchandren, A. Goy, J. V. Matous, A. A. Fasanmade, T. J. Manley and T. H. Han

      Accepted manuscript online: 26 APR 2016 11:25AM EST | DOI: 10.1111/bcp.12988

  14. Reviews

    1. Therapeutic Nucleic Acids: Current clinical status

      Nithya J. Gogtay and Kannan Sridharan

      Accepted manuscript online: 25 APR 2016 06:17AM EST | DOI: 10.1111/bcp.12987

  15. Review Themed Issue

    1. Polyphenol intake from a Mediterranean diet decreases inflammatory biomarkers related to atherosclerosis: A sub-study of The PREDIMED trial

      Alexander Medina-Remón, Rosa Casas, Anna Tressserra-Rimbau, Emilio Ros, Miguel A. Martínez-González, Montserrat Fitó, Dolores Corella, Jordi Salas-Salvadó, Rosa M. Lamuela-Raventos, Ramón Estruch and on behalf of the PREDIMED Study Investigators

      Accepted manuscript online: 21 APR 2016 04:05PM EST | DOI: 10.1111/bcp.12986

  16. Pharmacokinetics

    1. Pharmacokinetics of lamotrigine and its metabolite N-2-glucuronide: Influence of polymorphism of UDP-glucuronosyltransferases and drug transporters

      Daniela Milosheska, Bogdan Lorber, Tomaž Vovk, Matej Kastelic, Vita Dolžan and Iztok Grabnar

      Accepted manuscript online: 20 APR 2016 10:35AM EST | DOI: 10.1111/bcp.12984

  17. Pharmacoepidemiologies

    1. Evaluation of the risk of cardiovascular events with clarithromycin using both propensity score and self-controlled study designs.

      Adrian A. Root, Angel Y. S. Wong, Yonas Ghebremichael-Weldeselassie, Liam Smeeth, Krishnan Bhaskaran, Stephen J. W. Evans, Ruth Brauer, Ian Chi Kei Wong, Vidya Navaratnam and Ian Douglas

      Accepted manuscript online: 19 APR 2016 07:06AM EST | DOI: 10.1111/bcp.12983

  18. Meta-analysis

    1. Peripheral vasoconstriction induced by beta-blockers: a systematic review and a network meta-analysis.

      C. Khouri, T. Jouve, S. Blaise, P. Carpentier, J. L. Cracowski and M. Roustit

      Accepted manuscript online: 16 APR 2016 02:30PM EST | DOI: 10.1111/bcp.12980

  19. Drugs in Pregnancy and Lactation

    1. Atropinic burden of drugs during pregnancy and psychological development of children: a cohort study in the EFEMERIS database

      Anna-Belle Beau, Jean-Louis Montastruc, Isabelle Lacroix, François Montastruc, Caroline Hurault-Delarue and Christine Damase-Michel

      Accepted manuscript online: 16 APR 2016 01:50PM EST | DOI: 10.1111/bcp.12978

  20. Pharmacokinetics

    1. Population pharmacokinetic analysis to recommend the optimal dose of udenafil in patients with mild and moderate hepatic impairment

      Anhye Kim, Jongtae Lee, Donghoon Shin, Yong Jin Jung, Mi Young Bahng, Joo-Youn Cho and In-Jin Jang

      Accepted manuscript online: 16 APR 2016 01:10PM EST | DOI: 10.1111/bcp.12977

  21. Systematic Reviews

    1. Adverse effects of herbal or dietary supplements in G6PD deficiency: A systematic review

      Shaun Wen Huey Lee, Nai Ming Lai, Nathorn Chaiyakunapruk and David Weng Kwai Chong

      Accepted manuscript online: 15 APR 2016 05:55PM EST | DOI: 10.1111/bcp.12976

    2. The feasibility and the effect of deprescribing in older adults on mortality and health: A systematic review

      Amy T. Page, Rhonda M. Clifford, Kathleen Potter, Darren Schwartz and Christopher D. Etherton-Beer

      Accepted manuscript online: 14 APR 2016 03:45PM EST | DOI: 10.1111/bcp.12975

  22. Drug Safety

    1. Muscle rupture associated with statin use

      C. Ekhart, L. A. W. de Jong, L. D. Gross-Martirosyan and F. P. A. M. van Hunsel

      Accepted manuscript online: 13 APR 2016 06:05PM EST | DOI: 10.1111/bcp.12973

  23. Pharmacoeconomics

    1. What influences persistence with medicines? A multinational discrete choice experiment of 2549 patients

      Emily A. F. Holmes, Valerie L. Morrison and Dyfrig A. Hughes

      Accepted manuscript online: 13 APR 2016 11:00AM EST | DOI: 10.1111/bcp.12971

  24. Therapeutics

    1. Quantifying rigidity of Parkinson's disease in relation to laxative treatment: a service evaluation

      Aisha D. Augustin, André Charlett, Clive Weller, Sylvia M. Dobbs, David Taylor, Ingvar Bjarnason and R. John Dobbs

      Accepted manuscript online: 8 APR 2016 12:00PM EST | DOI: 10.1111/bcp.12967

  25. Reviews

    1. The Great ESCAPE-a Clinical Pharmacologist's Journey in Stroke Research

      David Williams

      Accepted manuscript online: 8 APR 2016 12:00PM EST | DOI: 10.1111/bcp.12966

  26. Pharmacoepidemiology

    1. High prevalence of risk factors in elderly patients using drugs related to acquired Torsades de Pointes chronically in Colombia

      Paula Andrea Moreno-Gutiérrez, Andrés Gaviria-Mendoza, Mauricio Montoya Cañón and Jorge Enrique Machado-Alba

      Accepted manuscript online: 8 APR 2016 11:53AM EST | DOI: 10.1111/bcp.12969

  27. Pharmacokinetics

    1. COMPARE: pharmacokinetic profiles of subcutaneous peginterferon beta-1a and subcutaneous interferon beta-1a over 2 weeks in healthy subjects

      Xiao Hu, Shulian Shang, Ivan Nestorov, Jawad Hasan, Ali Seddighzadeh, Katherine Dawson, Bjørn Sperling and Brian Werneburg

      Accepted manuscript online: 8 APR 2016 11:53AM EST | DOI: 10.1111/bcp.12968

  28. Reviews

    1. Injection Site Reactions after subcutaneous oligonucleotide therapy

      L. van Meer, M. Moerland, J. Gallagher, M. B. A. van Doorn, E. P. Prens, A. F. Cohen, R. Rissmann and J. Burggraaf

      Accepted manuscript online: 7 APR 2016 11:02AM EST | DOI: 10.1111/bcp.12961

  29. Review - Themed Issue

    1. Systems biology approaches to understand the effects of nutrition and promote health

      Lina Badimon, Gemma Vilahur and Teresa Padro

      Accepted manuscript online: 7 APR 2016 09:08AM EST | DOI: 10.1111/bcp.12965

  30. Drug Safety

    1. Ventricular tachyarrhythmia and sudden cardiac death with domperidone use in Parkinson's Disease

      Christel Renoux, Sophie Dell'Aniello, Paul Khairy, Connie Marras, Shawn Bugden, Tanvir Chowdhury Turin, Lucie Blais, Hala Tamim, Charity Evans, Russell Steele, Colin Dormuth, Pierre Ernst and The Canadian Network for Observational Drug Effect Studies (CNODES) Investigators

      Accepted manuscript online: 7 APR 2016 02:41AM EST | DOI: 10.1111/bcp.12964

  31. Pharmacokinetics

    1. Pharmacokinetics of the novel oral prostacyclin receptor agonist selexipag in subjects with hepatic or renal impairment

      Priska Kaufmann, Hans G. Cruz, Andreas Krause, Ivan Ulč, Atef Halabi and Jasper Dingemanse

      Accepted manuscript online: 7 APR 2016 12:50AM EST | DOI: 10.1111/bcp.12963

  32. PK-PD relationships

    1. Pharmacokinetic/pharmacodynamic modelling of the antimalarial effect of Actelion-451840 in an induced blood stage malaria study in healthy subjects

      Andreas Krause, Jasper Dingemanse, Alexandre Mathis, Louise Marquart, Jörg J. Möhrle and James S. McCarthy

      Accepted manuscript online: 6 APR 2016 05:27PM EST | DOI: 10.1111/bcp.12962

  33. Pharmacoepidemiology

    1. Prescribing pattern of antipsychotic drugs during the years 1996-2010: a population-based database study in Europe with a focus on torsadogenic drugs

      Alessandro Oteri, Giampiero Mazzaglia, Serena Pecchioli, Mariam Molokhia, Sinna Pilgaard Ulrichsen, Lars Pedersen, Elisabetta Poluzzi, Fabrizio De Ponti, Edeltraut Garbe, Tania Schink, Ron Herings, Irene D. Bezemer, Miriam C. J. M. Sturkenboom and Gianluca Trifirò

      Accepted manuscript online: 6 APR 2016 06:20AM EST | DOI: 10.1111/bcp.12955

    2. Usage patterns of single-ingredient and combined paracetamol in France

      Mai Duong, Sinem Ezgi Gulmez, Francesco Salvo, Abdelilah Abouelfath, Régis Lassalle, Cécile Droz, Patrick Blin and Nicholas Moore

      Accepted manuscript online: 5 APR 2016 09:26AM EST | DOI: 10.1111/bcp.12957

  34. Systematic Reviews

    1. Impact of strategies to reduce polypharmacy on clinically relevant endpoints - a systematic review and meta-analysis

      Tim Johansson, Muna E. Abuzahra, Sophie Keller, Eva Mann, Barbara Faller, Christina Sommerauer, Jennifer Höck, Christin Löffler, Anna Köchling, Jochen Schuler, Maria Flamm and Andreas Sönnichsen

      Accepted manuscript online: 5 APR 2016 09:26AM EST | DOI: 10.1111/bcp.12959

  35. Review - Themed Issue

    1. The Therapeutic Potential of mTOR Inhibitors in Breast Cancer

      Linda S. Steelman, Alberto M. Martelli, Lucio Cocco, Massimo Libra, Ferdinando Nicoletti, Stephen L. Abrams and James A. McCubrey

      Accepted manuscript online: 5 APR 2016 09:25AM EST | DOI: 10.1111/bcp.12958

  36. Paediatric Clinical Pharmacology

    1. Developing consensus on hospital prescribing indicators of potential harm for infants and children.

      Andy Fox, Sarah Pontefract, David Brown, Jane Portlock and Jamie Coleman

      Accepted manuscript online: 1 APR 2016 01:40PM EST | DOI: 10.1111/bcp.12954

  37. Others

  38. Clinical Trials

    1. Acute p-synephrine ingestion increases fat oxidation rate during exercise

      Jorge Gutiérrez-Hellín and Juan Del Coso

      Accepted manuscript online: 1 APR 2016 10:45AM EST | DOI: 10.1111/bcp.12952

  39. Drug Interactions

  40. Clinical Trials

    1. Pharmacodynamics, pharmacokinetics, and safety of ticagrelor in Chinese patients with stable coronary artery disease

      Haiyan Li, Jingchuan Guo, Glenn F. Carlson and Renli Teng

      Accepted manuscript online: 1 APR 2016 08:15AM EST | DOI: 10.1111/bcp.12950

  41. Review - Themed Issue

    1. Edible plants for oral delivery of biopharmaceuticals

      Matilde Merlin, Mario Pezzotti and Linda Avesani

      Accepted manuscript online: 1 APR 2016 06:26AM EST | DOI: 10.1111/bcp.12949

    2. Atheroprotective Effects of Conjugated Linoleic Acid

      R. Bruen, S. Fitzsimons and O. Belton

      Accepted manuscript online: 1 APR 2016 05:42AM EST | DOI: 10.1111/bcp.12948

  42. PK-PD relationships

    1. Exploring genetic and non-genetic risk factors for delayed graft function, acute and subclinical rejection in renal transplant recipients

      D.J.A.R. Moes, R.R. Press, O. Ackaert, B.A. Ploeger, F.J. Bemelman, C. Diack, J.A.M. Wessels, T. van der Straaten, M. Danhof, J.S. Sanders, J.J. Homan van der Heide, H.J. Guchelaar and J. W. de Fijter

      Accepted manuscript online: 30 MAR 2016 08:25AM EST | DOI: 10.1111/bcp.12946

  43. Pharmacoepidemiology

    1. EUROmediCAT signal detection: an evaluation of selected congenital anomaly-medication associations

      Joanne E. Given, Maria Loane, Johannes M. Luteijn, Joan K. Morris, Lolkje T. W. de Jong van den Berg, Ester Garne, Marie-Claude Addor, Ingeborg Barisic, Hermien de Walle, Miriam Gatt, Kari Klungsoyr, Babak Khoshnood, Anna Latos-Bielenska, Vera Nelen, Amanda J. Neville, Mary O'Mahony, Anna Pierini, David Tucker, Awi Wiesel and Helen Dolk

      Accepted manuscript online: 29 MAR 2016 10:55AM EST | DOI: 10.1111/bcp.12947

  44. Systematic Reviews

    1. Adverse Drug Event Reporting Systems-a Systematic Review

      Chantelle Bailey, David Peddie, Maeve E. Wickham, Katherin Badke, Serena S. Small, Mary M. Doyle-Waters, Ellen Balka and Corinne M. Hohl

      Accepted manuscript online: 25 MAR 2016 11:35PM EST | DOI: 10.1111/bcp.12944

  45. Review-Themed Issue

    1. Dietary anthocyanins and health: data from FLORA and ATHENA EU projects

      Chiara Cerletti, Amalia de Curtis, Francesca Bracone, Cinzia Digesù, Alessio G. Morganti, Licia Iacoviello, Giovanni de Gaetano and Maria Benedetta Donati

      Accepted manuscript online: 25 MAR 2016 10:15PM EST | DOI: 10.1111/bcp.12943

  46. Clinical Trials

    1. Pharmacokinetics and pharmacodynamics of multiple doses of BG00010, a neurotrophic factor with anti-hyperalgesic effects, in patients with sciatica

      P. Okkerse, J. L. Hay, E. Versage, Y. Tang, G. Galluppi, B. Ravina, A. Verma, L. Williams, E. Aycardi and G. J. Groeneveld

      Accepted manuscript online: 25 MAR 2016 08:00PM EST | DOI: 10.1111/bcp.12941

    2. Impact of patient characteristics on the pharmacokinetics of corifollitropin alfa during controlled ovarian stimulation

      Anthe S. Zandvliet, Marita Prohn, Rik de Greef, Frank van Aarle, Christine Mc Crary Sisk and Barbara J. Stegmann

      Accepted manuscript online: 18 MAR 2016 07:21AM EST | DOI: 10.1111/bcp.12939

  47. Pharmacoepidemiology

    1. Twenty-five years of prescription opioid use in Australia: A whole-of-population analysis using pharmaceutical claims

      Emily A. Karanges, Bianca Blanch, Nicholas A. Buckley and Sallie-Anne Pearson

      Accepted manuscript online: 18 MAR 2016 07:20AM EST | DOI: 10.1111/bcp.12937

  48. Review-Themed Issue

    1. Potential therapeutic effects of the mtor inhibitors for preventing ageing and progeria-related disorders

      Camilla Evangelisti, Vittoria Cenni and Giovanna Lattanzi

      Accepted manuscript online: 8 MAR 2016 02:29AM EST | DOI: 10.1111/bcp.12928

  49. Review - Themed Issue

    1. You have free access to this content
      It is rocket science – why dietary nitrate is hard to Beet! part II: further mechanisms and therapeutic potential of the nitrate-nitrite-NO pathway

      Charlotte Elizabeth Mills, Jibran Khatri, Perry Maskell, Chimed Odongerel and Andrew James Webb

      Accepted manuscript online: 23 FEB 2016 04:13AM EST | DOI: 10.1111/bcp.12918

  50. Review-Themed Issue

    1. It is Rocket Science – Why dietary nitrate is hard to beet! Part I: Twists and turns in the realisation of the nitrate-nitrite-NO pathway

      Jibran Khatri, Charlotte Elizabeth Mills, Perry Maskell, Chimed Odongerel and Andrew James Webb

      Accepted manuscript online: 20 FEB 2016 08:56AM EST | DOI: 10.1111/bcp.12913

  51. Meta Analysis (REV)

    1. Is the Era of intravenous proton pump inhibitors coming to an end in patients with bleeding peptic ulcers? meta-analysis of the published literature

      Zhixiang Jian, Hui Li, Nicholas S. Race, Tingting Ma, Haosheng Jin and Zi Yin

      Accepted manuscript online: 18 DEC 2015 03:49AM EST | DOI: 10.1111/bcp.12866


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