British Journal of Clinical Pharmacology

Cover image for Vol. 80 Issue 6

Accepted Articles (Accepted, unedited articles published online and citable. The final edited and typeset version of record will appear in future.)

Edited By: A.F. Cohen (Editor-in-Chief), Y.K. Loke (European Editor) A. de Boer (European Editor), A. Somogyi (Australasian Editor), D. Flockhart (American Editor), A. Ferro (Reviews Editor), A. Gilchrist (Online Editor) and S. Ross (Education Editor)

Impact Factor: 3.878

ISI Journal Citation Reports © Ranking: 2014: 46/255 (Pharmacology & Pharmacy)

Online ISSN: 1365-2125

Associated Title(s): British Journal of Pharmacology, Pharmacology Research & Perspectives


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  1. Clinical Trials

    1. The haemodynamic effects of intravenous paracetamol (acetaminophen) in healthy volunteers: a double-blinded, randomized, triple crossover trial

      Elizabeth Chiam, Laurence Weinberg, Michael Bailey, Larry McNicol and Rinaldo Bellomo

      Accepted manuscript online: 25 NOV 2015 05:07PM EST | DOI: 10.1111/bcp.12841

  2. Letters to Editor

    1. Gender difference in platelet aggregation and reactivity induced by recombinant human erythropoietin

      Lucrezia Gambardella, Rosa Vona, Simona Pichini, Roberta Pacifici, Walter Malorni and Elisabetta Straface

      Accepted manuscript online: 23 NOV 2015 04:27AM EST | DOI: 10.1111/bcp.12835

    2. Opioids in COPD: the ‘whole picture’ includes results from real-world, population-based observational studies

      Nicholas T Vozoris, Sudeep S Gill and Denis E O'Donnell

      Accepted manuscript online: 23 NOV 2015 03:09AM EST | DOI: 10.1111/bcp.12838

  3. Letter to the Editors

    1. The rest of the story of the letter to the editors: “Hypersensitivity to amoxicillin after… (DRESS) to carbamazepine…: a possible co-sensitization”

      Zohra Chadli, Nadia Ben Fredj, Monia Youssef, Amel Chaabane, Naceur A. Boughattas, Jamel Eddine Zili and Karim Aouam

      Accepted manuscript online: 23 NOV 2015 12:06AM EST | DOI: 10.1111/bcp.12823

  4. Review - Themed Issues

    1. Pharmacological management of anticholinergic delirium - theory, evidence and practice

      Andrew H. Dawson and Nicholas A. Buckley

      Accepted manuscript online: 21 NOV 2015 12:46AM EST | DOI: 10.1111/bcp.12839

  5. Clinical Trials

    1. Paracetamol decreases steady-state exposure to lamotrigine by induction of glucuronidation in healthy subjects

      Sandra Gastrup, Tore Bjerregaard Stage, Palle Bach Nielsen Fruekilde and Per Damkier

      Accepted manuscript online: 20 NOV 2015 05:00PM EST | DOI: 10.1111/bcp.12840

  6. Letter to the Editor

  7. Drug Metabolism

    1. Paracetamol (acetaminophen) protein adduct concentrations during therapeutic dosing

      Kennon Heard, Jody L. Green, Victoria Anderson, Becki Bucher-Bartelson and Richard C. Dart

      Accepted manuscript online: 19 NOV 2015 07:41PM EST | DOI: 10.1111/bcp.12831

  8. Clinical Trials

    1. Rivaroxaban compared with standard thromboprophylaxis after major orthopaedic surgery: co-medication interactions

      Reinhold Kreutz, Sylvia Haas, Gerlind Holberg, Michael R. Lassen, Lorenzo G. Mantovani, André Schmidt and Alexander G. G. Turpie

      Accepted manuscript online: 18 NOV 2015 04:00PM EST | DOI: 10.1111/bcp.12836

    2. Pharmacokinetics and pharmacodynamics of everolimus in patients with renal angiomyolipoma and tuberous sclerosis complex or lymphangioleiomyomatosis

      Klemens Budde, Bernard A. Zonnenberg, Michael Frost, Wing Cheung, Shweta Urva, Thomas Brechenmacher, Karen Stein, David Chen, J. Christopher Kingswood and John J. Bissler

      Accepted manuscript online: 18 NOV 2015 04:00PM EST | DOI: 10.1111/bcp.12834

  9. Pharmacokinetics

    1. External Evaluation of Published Population Pharmacokinetic Models of Tacrolimus in Adult Renal Transplant Recipients

      Chen-Yan Zhao, Zheng Jiao, Jun-Jun Mao and Xiao-Yan Qiu

      Accepted manuscript online: 17 NOV 2015 04:29AM EST | DOI: 10.1111/bcp.12830

  10. Pharmacoepidemiology

    1. Antidepressants and antipsychotics classified with Torsades de Pointes arrhythmia risk and mortality in older adults - a Swedish nationwide study

      B. Danielsson, J. Collin, G. Jonasdottir Bergman, N. Borg, P. Salmi and J. Fastbom

      Accepted manuscript online: 17 NOV 2015 01:44AM EST | DOI: 10.1111/bcp.12829

  11. Pharmacokinetics

    1. A comparison of the intrasubject variation of drug exposure between generic and brand-name drugs: a retrospective analysis of replicate design trials

      Yang Yu, Steven Teerenstra, Cees Neef, David Burger and Marc Maliepaard

      Accepted manuscript online: 17 NOV 2015 01:36AM EST | DOI: 10.1111/bcp.12828

  12. Translational Research

    1. P2Y12 receptor blockade synergises strongly with nitric oxide and prostacyclin to inhibit platelet activation

      Melissa V. Chan, Rebecca B. M. Knowles, Martina H. Lundberg, Arthur T. Tucker, Nura A. Mohamed, Nicholas S. Kirkby, Paul C. J. Armstrong, Jane A. Mitchell and Timothy D. Warner

      Accepted manuscript online: 11 NOV 2015 04:11PM EST | DOI: 10.1111/bcp.12826

  13. Review - Themed Issue

    1. Antidotes for poisoning by alcohols that form toxic metabolites

      Kenneth McMartin, Dag Jacobsen and Knut Erik Hovda

      Accepted manuscript online: 9 NOV 2015 03:58PM EST | DOI: 10.1111/bcp.12824

  14. Drug Metabolism

    1. Evaluation of an oral uracil loading test to identify DPD-deficient patients using a limited sampling strategy

      Maurice C. van Staveren, Andre B. P. van Kuilenburg, H. J. Guchelaar, Judith Meijer, Cornelis J. A. Punt, Robert S. de Jong, Hans Gelderblom and Jan Gerard Maring

      Accepted manuscript online: 9 NOV 2015 03:01PM EST | DOI: 10.1111/bcp.12821

  15. Review - Themed Issue

    1. Treatment of sulfonylurea and insulin overdose

      Wendy Klein-Schwartz, Gina L. Stassinos and Geoffrey K. Isbister

      Accepted manuscript online: 9 NOV 2015 03:01PM EST | DOI: 10.1111/bcp.12822

    2. Potential therapeutic effects of mTOR inhibition in atherosclerosis

      Ammar Kurdi, Guido R. Y. De Meyer and Wim Martinet

      Accepted manuscript online: 9 NOV 2015 10:21AM EST | DOI: 10.1111/bcp.12820

  16. Editorials

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      Identifying medical wearables and sensor technologies that deliver data on clinical endpoints

      Christophe Mombers, Kathleen Legako and Annette Gilchrist

      Accepted manuscript online: 6 NOV 2015 02:56AM EST | DOI: 10.1111/bcp.12818

  17. Methods in clinical pharmacology

    1. Creatinine-based equations for the adjustment of drug dosage in an obese population

      Antoine Bouquegneau, Emmanuelle Vidal-Petiot, Olivier Moranne, Christophe Mariat, Jean Jacques Boffa, François Vrtovsnik, Andre J. Scheen, Jean Marie Krzesinski, Martin Flamant and Pierre Delanaye

      Accepted manuscript online: 4 NOV 2015 04:06AM EST | DOI: 10.1111/bcp.12817

  18. Pharmacokinetics

    1. Use of an integrated modelling and simulation approach to develop a simplified peginterferon alfa-2a dosing regimen for children with hepatitis C

      Barbara J. Brennan, Annabelle Lemenuel-Diot, Eric Snoeck, Michael McKenna, Jonathan Solsky, Cynthia Wat and Navita L. Mallalieu

      Accepted manuscript online: 3 NOV 2015 09:04AM EST | DOI: 10.1111/bcp.12816

  19. Letter to the Editor

    1. Massive hyperhomocysteinemia as a complication of nitrous oxide inhalation

      Stanislas Faguer, Jean Ruiz and Arnaud Mari

      Accepted manuscript online: 1 NOV 2015 09:14PM EST | DOI: 10.1111/bcp.12813

  20. Letter to Editor

  21. Pharmacokinetics

    1. Prediction of human foetal pharmacokinetics using ex-vivo human placenta perfusion studies and Physiologically Based models

      Maïlys De Sousa Mendes, Deborah Hirt, Cécile Vinot, Elodie Valade, Gabrielle Lui, Claire Pressiat, Naïm Bouazza, Frantz Foissac, Stephane Blanche, Minh Patrick Lê, Gilles Peytavin, Jean-Marc Treluyer, Saik Urien and Sihem Benaboud

      Accepted manuscript online: 31 OCT 2015 05:58AM EST | DOI: 10.1111/bcp.12815

  22. Review - Themed Issue

    1. Pharmacological treatment of cardiac glycoside poisoning

      Darren M. Roberts, Gamini Galappatthy, Asunga Dunuwille and Betty S. Chan

      Accepted manuscript online: 27 OCT 2015 01:38PM EST | DOI: 10.1111/bcp.12814

  23. Clinical Trials

    1. Single dose delta-9-tetrahydrocannabinol in chronic pancreatitis patients: analgesic efficacy, pharmacokinetics and tolerability

      Marjan de Vries, Dagmar C. M. van Rijckevorsel, Kris C. P. Vissers, Oliver H. G. Wilder-Smith, Harry van Goor and Pain and Nociception Neuroscience Research Group

      Accepted manuscript online: 27 OCT 2015 01:01PM EST | DOI: 10.1111/bcp.12811

  24. Reviews

    1. The mass action equation in pharmacology

      Terry Kenakin

      Accepted manuscript online: 27 OCT 2015 12:34PM EST | DOI: 10.1111/bcp.12810

  25. Pharmacoepidemiology

    1. Tiotropium Respimat® vs. HandiHaler®: real-life usage and TIOSPIR trial generalizability

      Sven Schmiedl, Rainald Fischer, Luisa Ibanez, Joan Fortuny, Petra Thürmann, Elena Ballarín, Pili Ferrer, Monica Sabaté, Dominik Rottenkolber, Roman Gerlach, Martin Tauscher, Robert Reynolds, Joerg Hasford and Marietta Rottenkolber

      Accepted manuscript online: 27 OCT 2015 11:58AM EST | DOI: 10.1111/bcp.12808

    2. A population database study of outcomes associated with vitamin K antagonists in atrial fibrillation

      Patrick Blin, Caroline Dureau-Pournin, Regis Lassalle, Abdelilah Abouelfath, Cécile Droz-Perroteau and Nicholas Moore

      Accepted manuscript online: 22 OCT 2015 11:48PM EST | DOI: 10.1111/bcp.12807

  26. PK-PD relationships

    1. Population Pharmacokinetics of Nalmefene in Healthy Subjects and its Relation to μ-Opioid Receptor Occupancy

      Lars-Erik Broksø Kyhl, Shen Li, Kirstine Ullitz Faerch, Birgitte Soegaard, Frank Larsen and Johan Areberg

      Accepted manuscript online: 19 OCT 2015 08:50PM EST | DOI: 10.1111/bcp.12805

  27. Methods in clinical pharmacology

    1. A one-year retrospective audit of quality indicators of clinical pharmacological advice for personalized linezolid dosing: one stone for two birds?

      Federico Pea, Piergiorgio Cojutti, Lucia Dose and Massimo Baraldo

      Accepted manuscript online: 15 OCT 2015 12:58PM EST | DOI: 10.1111/bcp.12806

  28. Review - Themed Issue

    1. Targeting molecules to medicine with mTOR, autophagy, and neurodegenerative disorders

      Kenneth Maiese

      Accepted manuscript online: 15 OCT 2015 12:31PM EST | DOI: 10.1111/bcp.12804

  29. Reviews

    1. Can Paracetamol (Acetaminophen) be administered to Patients with Liver Impairment?

      Kelly L. Hayward, Elizabeth E. Powell, Katharine M. Irvine and Jennifer H. Martin

      Accepted manuscript online: 13 OCT 2015 04:21AM EST | DOI: 10.1111/bcp.12802

  30. Drug Interactions

    1. Celecoxib interferes to a limited extent with aspirin-mediated inhibition of platelets aggregation

      Mark Ruzov, Gilad Rimon, Oleg Pikovsky and David Stepensky

      Accepted manuscript online: 11 OCT 2015 11:38PM EST | DOI: 10.1111/bcp.12801

  31. Pharmacogenetics

    1. Genetic markers in CYP2C19 and CYP2B6 for prediction of cyclophosphamide's 4-hydroxylation, efficacy and side effects in Chinese systemic lupus erythematosus patients

      Wenying Shu, Su. Guan, Xiuyan Yang, Liuqin Liang, Jiali Li, Zhuojia Chen, Yu. Zhang, Lingyan Chen, Xueding Wang and Min Huang

      Accepted manuscript online: 11 OCT 2015 11:37PM EST | DOI: 10.1111/bcp.12800

  32. PK-PD relationships

    1. Predicting allopurinol response in patients with gout

      Daniel F. B. Wright, Stephen B. Duffull, Tony R. Merriman, Nicola Dalbeth, Murray L. Barclay and Lisa K. Stamp

      Accepted manuscript online: 9 OCT 2015 12:19PM EST | DOI: 10.1111/bcp.12799

  33. Therapeutics

    1. An open-label study in healthy men to evaluate the risk of seminal fluid transmission of denosumab to pregnant partners

      Winnie Sohn, Edward Lee, Martin K. Kankam, Ogo Egbuna, Graeme Moffat, Jeanine Bussiere, Desmond Padhi, Eric Ng, Sandeep Kumar and J. Greg Slatter

      Accepted manuscript online: 8 OCT 2015 05:06PM EST | DOI: 10.1111/bcp.12798

  34. Clinical Trials

    1. The early effect of sunitinib on insulin clearance in patients with metastatic renal cell carcinoma

      A. M. J. Thijs, C. J. Tack, W. T. A. van der Graaf, G. A. Rongen and C. M. L. van Herpen

      Accepted manuscript online: 8 OCT 2015 01:50PM EST | DOI: 10.1111/bcp.12797

  35. Pharmacokinetics

    1. A novel approach for estimating ingested dose associated with paracetamol overdose

      Todd J. Zurlinden, Kennon Heard and Brad Reisfeld

      Accepted manuscript online: 6 OCT 2015 12:21PM EST | DOI: 10.1111/bcp.12796

  36. Drug Interactions

    1. The pharmacokinetic and pharmacodynamic interaction of clopidogrel and cilostazol in relation to CYP2C19 and CYP3A5 genotypes

      Ho-Sook Kim, Younghae Lim, Minkyung Oh, Jong-lyul Ghim, Eun-Young Kim, Dong-Hyun Kim and Jae-Gook Shin

      Accepted manuscript online: 1 OCT 2015 04:02PM EST | DOI: 10.1111/bcp.12794

  37. Pharmacogenetics

    1. Beating the odds: efficacy and toxicity of DPD-driven adaptive dosing of 5-FU in patients with digestive cancer

      Manon Launay, Laetitia Dahan, Manon Duval, Anne Rodallec, Gérard Milano, Muriel Duluc, Bruno Lacarelle, Joseph Ciccolini and Jean-Francois Seitz

      Accepted manuscript online: 22 SEP 2015 05:12AM EST | DOI: 10.1111/bcp.12790

  38. Clinical Trials

    1. Stable isotope-intravenous microdose for absolute bioavailability and effect of grapefruit juice on ibrutinib in healthy adults

      Ronald de Vries, Johan W. Smit, Peter Hellemans, James Jiao, Joseph Murphy, Donna Skee, Jan Snoeys, Juthamas Sukbuntherng, Maarten Vliegen, Loeckie de Zwart, Erik Mannaert and Jan de Jong

      Accepted manuscript online: 18 SEP 2015 09:55AM EST | DOI: 10.1111/bcp.12787

  39. Meta Analysis (REV)

  40. PD relationships

    1. A pharmacokinetic-pharmacodynamic model for intrathecal baclofen in patients with severe spasticity

      Herre W Heetla, J H Proost, Barbara H Molmans, Michiel J Staal and Teus van Laar

      Accepted manuscript online: 10 SEP 2015 03:06PM EST | DOI: 10.1111/bcp.12781

  41. Pharmacokinetics

    1. Investigating pulmonary and systemic pharmacokinetics of inhaled olodaterol in healthy volunteers using a population pharmacokinetic approach

      Jens Markus Borghardt, Benjamin Weber, Alexander Staab, Christina Kunz, Stephan Formella and Charlotte Kloft

      Accepted manuscript online: 8 SEP 2015 09:07AM EST | DOI: 10.1111/bcp.12780

  42. Paediatric clinical pharmacology

    1. Bevacizumab dosing strategy in pediatric cancer patients based on population pharmacokinetic analysis with external validation

      Kelong Han, Thomas Peyret, Angelica Quartino, Nathalie H. Gosselin, Sridharan Gururangan, Najat C. Daw, Fariba Navid, Jin Jin and David E. Allison

      Accepted manuscript online: 7 SEP 2015 08:51PM EST | DOI: 10.1111/bcp.12778

  43. Therapeutics

    1. Alkali replacement raises urinary citrate excretion in patients with topiramate-induced hypocitraturia

      R. Allan Jhagroo, Margaret L. Wertheim and Kristina L. Penniston

      Accepted manuscript online: 22 AUG 2015 01:20PM EST | DOI: 10.1111/bcp.12751


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