British Journal of Clinical Pharmacology

Cover image for Vol. 81 Issue 2

Accepted Articles (Accepted, unedited articles published online and citable. The final edited and typeset version of record will appear in future.)

Edited By: A.F. Cohen (Editor-in-Chief), A. de Boer (European Editor), A. Ferro (Reviews Editor), A. Gilchrist (Online Editor), G. Isbister (Australasian Editor), S. Ross (Education Editor) and A. Webb (European Editor)

Impact Factor: 3.878

ISI Journal Citation Reports © Ranking: 2014: 46/255 (Pharmacology & Pharmacy)

Online ISSN: 1365-2125

Associated Title(s): British Journal of Pharmacology, Pharmacology Research & Perspectives


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  1. Systematic Reviews

    1. Effect of Monoclonal Antibodies to PCSK9 on high-sensitivity C-reactive protein levels: A Meta-Analysis of 16 Randomized Controlled Treatment Arms

      Amirhossein Sahebkar, Paolo Di Giosia, Cosimo Andrea Stamerra, Davide Grassi, Claudio Pedone, Ferretti Gianna, Bacchetti Tiziana, Claudio Ferri and Paolo Giorgini

      Accepted manuscript online: 9 FEB 2016 11:28PM EST | DOI: 10.1111/bcp.12905

  2. Paediatric Clinical Pharmacology

    1. Pragmatic Pharmacology: Population Pharmacokinetic Analysis of Fentanyl using Remnant Samples from Children after Cardiac Surgery

      S. L. Van Driest, M. D. Marshall, B. Hachey, C. Beck, K. Crum, J. Owen, A. H. Smith, P. J. Kannankeril, A. Woodworth, R. M. Caprioli and L. Choi

      Accepted manuscript online: 9 FEB 2016 10:39PM EST | DOI: 10.1111/bcp.12903

  3. Drug Interactions

    1. Fulvestrant decreases anastrozole drug concentrations when taken concurrently by patients with metastatic breast cancer treated on SWOG study S0226

      Daniel L. Hertz, William E. Barlow, Kelley M. Kidwell, Kathy S. Albain, Ted A. Vandenberg, Shaker R. Dakhil, Nagendra R. Tirumali, Robert B. Livingston, Julie Gralow, Daniel F. Hayes, Gabriel N. Hortobagyi, Rita S. Mehta and James M. Rae

      Accepted manuscript online: 9 FEB 2016 08:30AM EST | DOI: 10.1111/bcp.12904

  4. PK-PD relationships

    1. Safety, Pharmacokinetics and Pharmacodynamics of GLPG0974, a potent and selective FFA2 antagonist, in healthy male subjects

      Florence Namour, Rená Galien, Tim Van Kaem, Annegret Van der Aa, Frédéric Vanhoutte, Johan Beetens and Gerben van't Klooster

      Accepted manuscript online: 8 FEB 2016 02:46AM EST | DOI: 10.1111/bcp.12900

  5. Pharmacokinetics

    1. Pooled population pharmacokinetic model of imipenem in plasma and the lung epithelial lining fluid

      J. G. Coen van Hasselt, Matthew L. Rizk, Mallika Lala, Cynthia Chavez-Eng, Sandra A. G. Visser, Thomas Kerbusch, Meindert Danhof, Gauri Rao and Piet H. van der Graaf

      Accepted manuscript online: 6 FEB 2016 10:11AM EST | DOI: 10.1111/bcp.12901

  6. Review - Themed Issue

    1. The Role of Nutraceuticals for the Treatment of Non-Alcoholic Fatty Liver Disease

      Maria Del Ben, Licia Polimeni, Francesco Baratta, Daniele Pastori and Francesco Angelico

      Accepted manuscript online: 6 FEB 2016 09:42AM EST | DOI: 10.1111/bcp.12899

  7. Letter to the Editor

    1. Meta-analysis Requires Independent Observations and Freedom from Bias

      Michael B. Bracken

      Accepted manuscript online: 4 FEB 2016 09:00AM EST | DOI: 10.1111/bcp.12898

  8. Editorials

    1. You have free access to this content
      Big Data: Challenges and Opportunities for Clinical Pharmacology

      David Flockhart, Robert R Bies, Marc R. Gastonguay and Sorell L. Schwartz

      Accepted manuscript online: 4 FEB 2016 08:34AM EST | DOI: 10.1111/bcp.12896

  9. Pharmacodynamics

    1. A Model-Based Approach to Assess the Exposure-Response Relationship of Lorenzo's Oil in Adrenoleukodystrophy

      Mariam A. Ahmed, Reena V. Kartha, Richard Brundage, James Cloyd, Cynthia Basu, Bradley P. Carlin, Richard O. Jones, Ann B. Moser, Ali Fatemi and Gerald V. Raymond

      Accepted manuscript online: 2 FEB 2016 09:11AM EST | DOI: 10.1111/bcp.12897

  10. Drug Interactions

    1. Effect of esomeprazole on the oral absorption of dasatinib in a patient with Philadelphia-positive acute lymphoblastic leukemia

      Elise Pape, Delphine Michel, Julien Scala-Bertola, Thomas Schiestel, Alexandre Harlé, Stéphane Bouchet, Audrey Contet, Cécile Pochon and Nicolas Gambier

      Accepted manuscript online: 1 FEB 2016 03:30AM EST | DOI: 10.1111/bcp.12895

  11. Reviews - Themed Issue

    1. Who Gets Antidotes? Choosing the Chosen Few

      Nicholas A. Buckley, Andrew H. Dawson, David N. Juurlink and Geoffrey K. Isbister

      Accepted manuscript online: 27 JAN 2016 08:20AM EST | DOI: 10.1111/bcp.12894

    2. New perspectives on mTOR inhibitors (Rapamycin, Rapalogs and TORKinibs) in transplantation

      Matthias Waldner, Daniel Fantus, Mario Solari and Angus W. Thomson

      Accepted manuscript online: 26 JAN 2016 05:25AM EST | DOI: 10.1111/bcp.12893

  12. Pharmacokinetics

    1. Population pharmacokinetics of oseltamivir and oseltamivir carboxylate in obese and Non-obese volunteers

      Kalayanee Chairat, Podjanee Jittamala, Warunee Hanpithakpong, Nicholas P. J. Day, Nicholas J. White, Sasithon Pukrittayakamee and Joel Tarning

      Accepted manuscript online: 26 JAN 2016 05:25AM EST | DOI: 10.1111/bcp.12892

  13. Pharmacodynamics

    1. A model-based evaluation of single metrics for discriminating changes in rheumatoid arthritis disease activity

      Jessica Wojciechowski, Michael D. Wiese, Susanna M. Proudman, David J. R. Foster and Richard N. Upton

      Accepted manuscript online: 26 JAN 2016 03:55AM EST | DOI: 10.1111/bcp.12891

  14. Drug Metabolism

    1. Scaling factors for the in vitro-in vivo extrapolation (IV-IVE) of renal drug and xenobiotic glucuronidation clearance

      Kathleen M. Knights, Shane M. Spencer, John K. Fallon, Nuy Chau, Philip C. Smith and John O. Miners

      Accepted manuscript online: 25 JAN 2016 02:41PM EST | DOI: 10.1111/bcp.12889

  15. Review-Themed Issue

    1. You have free access to this content
      Targeting mTOR for the treatment of B cell malignancies

      J. Scott Lee, Thanh-Trang Vo and David A. Fruman

      Accepted manuscript online: 25 JAN 2016 03:31AM EST | DOI: 10.1111/bcp.12888

  16. Pharmacokinetics

    1. Single dose sublingual testosterone and oral sildenafil versus a dual-route/dual-release fixed-dose combination tablet: a pharmacokinetic comparison

      J. Bloemers, K. van Rooij, L. de Leede, H. W. Frijlink, H. P. F. Koppeschaar, B. Olivier and A. Tuiten

      Accepted manuscript online: 25 JAN 2016 12:39AM EST | DOI: 10.1111/bcp.12887

  17. Pharmacogenetics

    1. Association of CYP2C19*2 and Associated Haplotypes with Lower Norendoxifen Levels in Tamoxifen-treated Asian Breast Cancer Patients

      Joanne Siok Liu Lim, Natalia Sutiman, Thomas E. Muerdter, Onkar Singh, Yin Bun Cheung, Raymond Chee Hui Ng, Yoon Sim Yap, Nan Soon Wong, Peter Ang Cher Siang, Rebecca Dent, Werner Schroth, Matthias Schwab and Balram Chowbay

      Accepted manuscript online: 22 JAN 2016 04:46AM EST | DOI: 10.1111/bcp.12886

  18. Reviews

    1. Mechanism of isoniazid-induced hepatotoxicity: then and now

      Imir G. Metushi, Jack Uetrecht and Elizabeth Phillips

      Accepted manuscript online: 15 JAN 2016 06:41PM EST | DOI: 10.1111/bcp.12885

  19. Pharmacokinetics

    1. You have full text access to this OnlineOpen article
      Absence of ethnic differences in the pharmacokinetics of moxifloxacin, simvastatin, and meloxicam among three East Asian populations and Caucasians

      Tomoko Hasunuma, Masahiro Tohkin, Nahoko Kaniwa, In-Jin Jang, Cui Yimin, Masaru Kaneko, Yoshiro Saito, Masahiro Takeuchi, Hiroshi Watanabe, Yasushi Yamazoe, Yoshiaki Uyama and Shinichi Kawai

      Accepted manuscript online: 15 JAN 2016 06:40PM EST | DOI: 10.1111/bcp.12884

    2. Altered gentamicin pharmacokinetics in term neonates undergoing controlled hypothermia

      Yuma A. Bijleveld, Timo R. de Haan, Johanna H. van der Lee, Floris Groenendaal, Peter H. Dijk, Arno van Heijst, Rogier C. J. de Jonge, Koen P. Dijkman, Henrica L. M. van Straaten, Monique Rijken, Inge A. Zonnenberg, Filip Cools, A. Zecic, Debbie Nuytemans, Anton H. van Kaam, Ron A. A. Mathot and for the PharmaCool study group

      Accepted manuscript online: 13 JAN 2016 01:33AM EST | DOI: 10.1111/bcp.12883

  20. Systematic Reviews

    1. N-acetylcysteine for non-paracetamol drug-induced liver injury: a systematic review

      Mohamed Farouk Chughlay, Nicole Kramer, C. Wendy Spearman, Mahmoud Werfalli and Karen Cohen

      Accepted manuscript online: 12 JAN 2016 06:49AM EST | DOI: 10.1111/bcp.12880

  21. Translational Research

    1. Rotigaptide protects the myocardium and arterial vasculature from Ischaemia reperfusion injury

      Christian M. Pedersen, Sowmya Venkatasubramanian, Henrik Vase, Janus A. Hyldebrandt, Hussain Contractor, Michael R. Schmidt, Hans E. Bøtker, Nicholas L. Cruden, David E. Newby, Raj K. Kharbanda and Ninian N. Lang

      Accepted manuscript online: 11 JAN 2016 01:12AM EST | DOI: 10.1111/bcp.12882

  22. Reviews

    1. The potential exploitation of research participants in high income countries who lack access to health care

      Rafael Dal-Ré, Annette Rid, Ezekiel Emanuel and David Wendler

      Accepted manuscript online: 6 JAN 2016 08:11PM EST | DOI: 10.1111/bcp.12879

  23. Paediatric clinical pharmacology

    1. You have full text access to this OnlineOpen article
      Development of a physiologically based pharmacokinetic model of actinomycin D in children with cancer

      Christopher Walsh, Jennifer J. Bonner, Trevor N. Johnson, Sibylle Neuhoff, Essam A. Ghazaly, John G. Gribben, Alan V. Boddy and Gareth J. Veal

      Accepted manuscript online: 4 JAN 2016 05:50AM EST | DOI: 10.1111/bcp.12878

  24. Pharmacokinetics

    1. Exploring the intracellular pharmacokinetics of the 5-fluorouracil nucleotides during capecitabine treatment

      Ellen J. B. Derissen, Bart A. W. Jacobs, Alwin D. R. Huitema, Hilde Rosing, Jan H. M. Schellens and Jos H. Beijnen

      Accepted manuscript online: 31 DEC 2015 12:44AM EST | DOI: 10.1111/bcp.12877

  25. Systematic Reviews

  26. Reviews

    1. Review of commonly used age based weight estimates for paediatric drug dosing in relation to the pharmacokinetic properties of resuscitation drugs

      Clare Francesca Carasco, Penny Fletcher and Ian Maconochie

      Accepted manuscript online: 29 DEC 2015 09:15AM EST | DOI: 10.1111/bcp.12876

  27. Pharmacokinetics

    1. Influence of tumour burden on trastuzumab pharmacokinetics in HER2 positive non-metastatic breast cancer

      Guillemette Bernadou, Mario Campone, Jean-Louis Merlin, Valérie Gouilleux-Gruart, Thomas Bachelot, François Lokiec, Keyvan Rezai, Monica Arnedos, Véronique Diéras, Martha Jimenez, Gilles Paintaud and David Ternant

      Accepted manuscript online: 29 DEC 2015 08:25AM EST | DOI: 10.1111/bcp.12875

    2. Pharmacokinetics and tolerability of paritaprevir, a direct-acting antiviral agent for HCV treatment, with and without ritonavir in healthy volunteers

      Rajeev M. Menon, Cheri E. Klein, Thomas J. Podsadecki, Yi-Lin Chiu, Sandeep Dutta and Walid M. Awni

      Accepted manuscript online: 28 DEC 2015 02:43PM EST | DOI: 10.1111/bcp.12873

  28. Drugs in Pregnancy and Lactation

    1. Reproductive Outcomes Following Hydroxychloroquine Use for Autoimmune Diseases: A Systematic Review and Meta-analysis

      Yusuf Cem Kaplan, Jak Ozsarfati, Cheri Nickel and Gideon Koren

      Accepted manuscript online: 23 DEC 2015 04:56PM EST | DOI: 10.1111/bcp.12872

  29. Editorials

    1. You have free access to this content
      The thorough QT study – do we need more of the same?

      Yoon K. Loke

      Accepted manuscript online: 22 DEC 2015 12:50AM EST | DOI: 10.1111/bcp.12871

  30. Letter to the Editor

    1. Reduction of hyperbilirubinemia with hypericum extract (St. John’s Wort) in a patient with Crigler-Najjar syndrome type II

      Oliver Kummer, Felix Hammann, Manuel Haschke and Stephan Krähenbühl

      Accepted manuscript online: 21 DEC 2015 08:31PM EST | DOI: 10.1111/bcp.12869

  31. Book Reviews

    1. Vie D'Or – memoirs of a pharmaceutical physician

      Brian Gennery

      Accepted manuscript online: 21 DEC 2015 05:01PM EST | DOI: 10.1111/bcp.12870

  32. Meta Analysis (REV)

    1. Is the Era of intravenous proton pump inhibitors coming to an end in patients with bleeding peptic ulcers? meta-analysis of the published literature

      Zhixiang Jian, Hui Li, Nicholas S. Race, Tingting Ma, Haosheng Jin and Zi Yin

      Accepted manuscript online: 18 DEC 2015 03:49AM EST | DOI: 10.1111/bcp.12866

  33. Letter to the Editor

    1. Evaluating pharmacotherapy education: urgent need for hard outcomes

      David J. Brinkman, Carolina J. P. W. Keijsers, Jelle Tichelaar, Milan C. Richir and Michiel A. van Agtmael

      Accepted manuscript online: 13 DEC 2015 09:25PM EST | DOI: 10.1111/bcp.12862

  34. Pharmacokinetics

    1. Population pharmacokinetic analysis of sifalimumab from a clinical phase IIb trial in systemic lupus erythematosus patients

      Bo. Zheng, Xiang-Qing Yu, Warren Greth and Gabriel J. Robbie

      Accepted manuscript online: 13 DEC 2015 09:25PM EST | DOI: 10.1111/bcp.12864

  35. Pharmacodynamics

    1. You have full text access to this OnlineOpen article
      The effect of LCZ696 on amyloid-β concentrations in cerebrospinal fluid in healthy subjects

      Thomas H. Langenickel, Chiaki Tsubouchi, Surya Ayalasomayajula, Parasar Pal, Marie-Anne Valentin, Markus Hinder, Stanford Jhee, Hakop Gevorkyan and Iris Rajman

      Accepted manuscript online: 12 DEC 2015 12:33AM EST | DOI: 10.1111/bcp.12861

  36. Pharmacokinetics

    1. Pharmacokinetics and pharmacodynamics of γ-hydroxybutyrate in healthy subjects

      Matthias E. Liechti, Boris B. Quednow, Evangelia Liakoni, Dario Dornbierer, Robin von Rotz, M. Salomé Gachet, Jürg Gertsch, Erich Seifritz and Oliver G. Bosch

      Accepted manuscript online: 11 DEC 2015 10:16AM EST | DOI: 10.1111/bcp.12863

    2. Pharmacokinetics and safety of single doses of tabalumab in subjects with rheumatoid arthritis or systemic lupus erythematosus

      Jennifer Witcher, Roy Fleischmann, Vishala L. Chindalore, Ryan J. Hansen, Leijun Hu, David Radtke, James Voelker, Elisa Gomez and Juliet McColm

      Accepted manuscript online: 9 DEC 2015 05:08AM EST | DOI: 10.1111/bcp.12860

  37. Clinical Trials

    1. Application of Pharmacometric Approaches to Evaluate Effect of Weight and Renal Function on Pharmacokinetics of Alogliptin

      Himanshu Naik, Richard Czerniak and Majid Vakilynejad

      Accepted manuscript online: 30 NOV 2015 01:04AM EST | DOI: 10.1111/bcp.12853

  38. Pharmacokinetics

    1. You have full text access to this OnlineOpen article
      Population pharmacokinetics of tanezumab in phase 3 clinical trials for osteoarthritis pain

      E. Niclas Jonsson, Rujia Xie, Scott F. Marshall and Rosalin H. Arends

      Accepted manuscript online: 27 NOV 2015 09:16AM EST | DOI: 10.1111/bcp.12850

  39. Clinical Trials

    1. You have full text access to this OnlineOpen article
      Rivaroxaban compared with standard thromboprophylaxis after major orthopaedic surgery: co-medication interactions

      Reinhold Kreutz, Sylvia Haas, Gerlind Holberg, Michael R. Lassen, Lorenzo G. Mantovani, André Schmidt and Alexander G. G. Turpie

      Accepted manuscript online: 18 NOV 2015 04:00PM EST | DOI: 10.1111/bcp.12836

    2. Pharmacokinetics and pharmacodynamics of everolimus in patients with renal angiomyolipoma and tuberous sclerosis complex or lymphangioleiomyomatosis

      Klemens Budde, Bernard A. Zonnenberg, Michael Frost, Wing Cheung, Shweta Urva, Thomas Brechenmacher, Karen Stein, David Chen, J. Christopher Kingswood and John J. Bissler

      Accepted manuscript online: 18 NOV 2015 04:00PM EST | DOI: 10.1111/bcp.12834

  40. Pharmacokinetics

    1. External Evaluation of Published Population Pharmacokinetic Models of Tacrolimus in Adult Renal Transplant Recipients

      Chen-Yan Zhao, Zheng Jiao, Jun-Jun Mao and Xiao-Yan Qiu

      Accepted manuscript online: 17 NOV 2015 04:29AM EST | DOI: 10.1111/bcp.12830

  41. Translational Research

    1. You have full text access to this OnlineOpen article
      P2Y12 receptor blockade synergises strongly with nitric oxide and prostacyclin to inhibit platelet activation

      Melissa V. Chan, Rebecca B. M. Knowles, Martina H. Lundberg, Arthur T. Tucker, Nura A. Mohamed, Nicholas S. Kirkby, Paul C. J. Armstrong, Jane A. Mitchell and Timothy D. Warner

      Accepted manuscript online: 11 NOV 2015 04:11PM EST | DOI: 10.1111/bcp.12826

  42. Pharmacokinetics

    1. Investigating pulmonary and systemic pharmacokinetics of inhaled olodaterol in healthy volunteers using a population pharmacokinetic approach

      Jens Markus Borghardt, Benjamin Weber, Alexander Staab, Christina Kunz, Stephan Formella and Charlotte Kloft

      Accepted manuscript online: 8 SEP 2015 09:07AM EST | DOI: 10.1111/bcp.12780


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