British Journal of Dermatology

Cover image for Vol. 174 Issue 2

Editor: Alex Anstey, Bangor, UK

Impact Factor: 4.275

ISI Journal Citation Reports © Ranking: 2014: 6/63 (Dermatology)

Online ISSN: 1365-2133

Associated Title(s): Clinical and Experimental Dermatology

Image Gallery

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    Histological features of a gastrointestinal polyp, which is associated with basal cell naevus syndrome. (The magnification level is ×60)

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    Basal cell naevus syndrome. The top panels show panoramic views of the jaw, showing multiple keratocystic odontogenic tumours. The lower panel shows calcification of the falx cerebri and meninges.

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    Baicalein attenuates scar hypertrophy and collagen production in vivo. (a) Images of scars 14 days postincision of control mice and baicalein-treated mice. (b) Images of haematoxylin and eosin (H&E)-stained sections. The dashed lines outline the scar. (c) Images of sections with Masson trichrome staining were used to measure the scar elevation index (SEI). ‘D’ represents the thickness of the scar while ‘d’ represents the thickness of adjacent normal skin. SEI is defined as the D/d ratio. (d) Picrosirius red staining. (e) Picrosirius red staining under polarized light and quantification of collagen density. Data are the mean ± SEM. n = 6/6; **P < 0·01; ***P < 0·001. DMSO, dimethylsulfoxide control.

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    Baicalein attenuates hypertrophic scar-derived fibroblast (HSF) activation in vivo and in vitro. (a) Representative images of scar sections with immunohistochemical staining indicating α-smooth muscle actin (α-SMA)-positive cells, 14 (n = 6/6) or 28 (n = 6/6) days postincision with dimethylsulfoxide (DMSO) or baicalein treatment. (b) Quantification of the percentage of α-SMA-positive cells. (c) Immunofluorescence staining for α-SMA and F-actin in cultured HSFs after incubation with transforming growth factor (TGF)-β1 (2 ng mL−1) and DMSO or baicalein for 48 or 72 h. α-SMA is shown by red fluorescence and F-actin by green fluorescence. (d, e) The level of α-SMA in human HSFs pretreated with TGF-β1 and baicalein at different concentrations was detected using Western blotting and thereafter quantified. Data are the mean ± SEM. **P < 0·01; ***P < 0·001. DAPI, 4ʹ,6-diamidino-2-phenylindole; GAPDH, glyceraldehyde 3-phosphate dehydrogenase.

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    Lentigo maligna lesion on the cheek prior to imiquimod therapy.

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    Brown palmar pigmentation.

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    Accepted manuscript online: 13 FEB 2016 03:21AM EST | DOI: 10.1111/bjd.14476

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