British Journal of Dermatology

Cover image for Vol. 175 Issue S1

Early View (Online Version of Record published before inclusion in an issue)

Editor: Alex Anstey, Bangor, UK

Impact Factor: 4.317

ISI Journal Citation Reports © Ranking: 2015: 5/61 (Dermatology)

Online ISSN: 1365-2133

Associated Title(s): Clinical and Experimental Dermatology

VIEW

  1. 1 - 100
  2. 101 - 109
  1. Translational Research

    1. Development of stratum corneum chymotrypsin-like protease activity and natural moisturizing factors from birth to 4 weeks of age compared with adults

      J. Chittock, A. Cooke, T. Lavender, K. Brown, A. Wigley, S. Victor, M.J. Cork and S.G. Danby

      Version of Record online: 22 JUL 2016 | DOI: 10.1111/bjd.14568

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      What's already known about this topic?

      • From birth the acidification and hydration of the infant stratum corneum to adult levels suggests transitory mechanisms underlying differentiation and desquamation.

      What does this study add?

      • Superficial chymotrypsin-like protease activity and natural moisturizing factors (NMF) increase from birth to 4 weeks of age and differ from those of adults.
      • Impaired barrier function at birth is accompanied by elevated protease activity and reduced NMF, highlighting why certain infants are predisposed to epidermal barrier breakdown and the development of atopic dermatitis (AD).

      What is the translational message?

      • Our data reinforce the need for infant skincare regimens from birth that protect and support normal barrier development.
      • Targeted skincare strategies to ameliorate heightened protease activity and low NMF may be an important preventative measure for neonates at increased risk of developing AD.
  2. Research Letters

    1. Iatrogenic delusional infestation: an observational study

      C.L. Marshall, C. Ellis, V. Williams, R.E. Taylor and A.P. Bewley

      Version of Record online: 22 JUL 2016 | DOI: 10.1111/bjd.14558

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    2. Fine arts curriculum improves observational skills of dermatology trainees: a pilot study

      J.T. Huang, S.D. Reynolds, B. DiGiovanni Evans, C. Zimmermann, C.J. Joyce, J.T. Katz and E. Buzney

      Version of Record online: 22 JUL 2016 | DOI: 10.1111/bjd.14616

    3. Major psychological complications and decreased health-related quality of life among survivors of Stevens–Johnson syndrome and toxic epidermal necrolysis

      R.P. Dodiuk-Gad, C. Olteanu, A. Feinstein, R. Hashimoto, R. Alhusayen, S. Whyte-Croasdaile, Y. Finkelstein, M. Burnett, S. Sade, R. Cartotto, M. Jeschke and N.H. Shear

      Version of Record online: 21 JUL 2016 | DOI: 10.1111/bjd.14799

  3. Letters to the Editor

    1. Vitiligo: a potential autoimmune sequela of DRESS syndrome

      S. Lonowski, J. Hau and S. Worswick

      Version of Record online: 20 JUL 2016 | DOI: 10.1111/bjd.14625

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  4. Epidemiology

    1. Bullous pemphigoid and dipeptidyl peptidase IV inhibitors: a case–noncase study in the French Pharmacovigilance Database

      J. Béné, G. Moulis, I. Bennani, M. Auffret, P. Coupe, S. Babai, D. Hillaire-Buys, J. Micallef, S. Gautier and the French Association of Regional PharmacoVigilance Centres

      Version of Record online: 19 JUL 2016 | DOI: 10.1111/bjd.14601

      What's already known about this topic?

      • Implication of dipeptidyl peptidase (DPP)-IV inhibitors in bullous pemphigoid occurrence has been suggested in several case reports.

      What does this study add?

      • There is a significant signal for an increased risk of bullous pemphigoid during DPP-IV inhibitor exposure.
      • This signal is outlined for each DPP-IV inhibitor, suggesting a class effect.
      • The signal of risk of bullous pemphigoid is higher with vildagliptin than with other DPP-IV inhibitors.
  5. Meeting Reports

    1. You have full text access to this OnlineOpen article
      Report from the fourth international consensus meeting to harmonize core outcome measures for atopic eczema/dermatitis clinical trials (HOME initiative)

      J.R. Chalmers, E. Simpson, C.J. Apfelbacher, K.S. Thomas, L. von Kobyletzki, J. Schmitt, J.A. Singh, Å. Svensson, H.C. Williams, K. Abuabara, V. Aoki, M. Ardeleanu, M. Awici-Rasmussen, S. Barbarot, T.L. Berents, J. Block, A. Bragg, T. Burton, K.K. Bjerring Clemmensen, A. Creswell-Melville, M. Dinesen, A. Drucker, L. Eckert, C. Flohr, M. Garg, L.A.A. Gerbens, A.L.B. Graff, J. Hanifin, D. Heinl, R. Humphreys, H.A. Ishii, Y. Kataoka, Y.A. Leshem, B. Marquort, M.-A. Massuel, S. Merhand, H. Mizutani, H. Murota, D.F. Murrell, T. Nakahara, I. Nasr, K. Nograles, Y. Ohya, I. Osterloh, J. Pander, C. Prinsen, L. Purkins, M. Ridd, T. Sach, M.-L. A. Schuttelaar, S. Shindo, J. Smirnova, A. Sulzer, E. Synnøve Gjerde, R. Takaoka, H. Vestby Talmo, M. Tauber, F. Torchet, A. Volke, C.-F. Wahlgren, S. Weidinger, E. Weisshaar, A. Wollenberg, K. Yamaga, C.Y. Zhao and P.I. Spuls

      Version of Record online: 19 JUL 2016 | DOI: 10.1111/bjd.14773

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      What's already known about this topic?

      • Previous meetings of the Harmonising Outcome Measures for Eczema (HOME) initiative have achieved international consensus that the domains of clinician-reported signs, patient-reported symptoms, quality of life and long-term control should be measured as the core outcomes for atopic eczema clinical trials.
      • It has been recommended that clinician-reported signs should be measured using the Eczema Area and Severity Index.

      What does this study add?

      • During the HOME IV meeting (Spring 2015, Malmö, Sweden), a consensus was achieved that the Patient-Oriented Eczema Measure should be used to capture patient-reported symptoms in future atopic eczema trials.
      • The remaining two core outcome domains of quality of life and long-term control require further work to determine the preferred core outcome measurement instruments.
  6. Systematic Reviews

    1. Efficacy, effectiveness and safety of fumaric acid esters in the treatment of psoriasis: a systematic review of randomized and observational studies

      D.M.W. Balak, S. Fallah Arani, E. Hajdarbegovic, C.A.F. Hagemans, W.M. Bramer, H.B. Thio and H.A.M. Neumann

      Version of Record online: 19 JUL 2016 | DOI: 10.1111/bjd.14500

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      What's already known about this topic?

      • The introduction of fumaric acid esters (FAEs) for the treatment of psoriasis has not been based on high-quality evidence stemming from well-performed randomized controlled trials.
      • FAEs are licensed in Germany. Outside Germany, the use of FAEs to treat psoriasis has been limited and is unlicensed.

      What does this study add?

      • This systemic review provides a comprehensive summary and appraisal of available studies that reported the clinical effects of FAEs in patients with psoriasis.
      • There was low-quality evidence to recommend the use of FAEs for the treatment of psoriasis with unclear and high-risk studies reporting favourable efficacy and tolerability of FAEs.
      • Studies on the long-term use of FAEs and comparative studies were lacking.
  7. Book Reviews

  8. Translational Research

    1. KIR3DL2 (CD158k) is a potential therapeutic target in primary cutaneous anaplastic large-cell lymphoma

      M. Battistella, A. Janin, F. Jean-Louis, C. Collomb, C. Leboeuf, H. Sicard, C. Bonnafous, A. Dujardin, C. Ram-Wolff, M.E. Kadin, A. Bensussan, M. Bagot and L. Michel

      Version of Record online: 13 JUL 2016 | DOI: 10.1111/bjd.14626

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      What's already known about this topic?

      • KIR3DL2 (CD158k) is expressed aberrantly in Sézary syndrome and transformed mycosis fungoides tumour cells.
      • The IPH4102 anti-KIR3DL2 humanized monoclonal antibody has shown potent antitumour activity against Sézary cells in preclinical studies.

      What does this study add?

      • KIR3DL2 is expressed by tumour cells in primary cutaneous anaplastic large-cell lymphoma (pcALCL) and by CD30+ lymphoproliferative disease cell lines.
      • IPH4102 has potent antitumour activity against CD30+ lymphoproliferative disease cell lines in vitro.

      What is the translational message?

      • KIR3DL2 expression by tumour cells in pcALCL and by CD30+ lymphoproliferative disease cell lines is associated with the potent antitumour activity of IPH4102 against CD30+ lymphoproliferative disease cell lines in vitro.
      • This suggests that therapeutic targeting of KIR3DL2 might be a future innovative treatment for patients with pcALCL.
  9. General Dermatology

    1. Influence of meteorological data on sun tolerance in patients with erythropoietic protoporphyria in France

      S. de Bataille, H. Dutartre, H. Puy, J.-C. Deybach, L. Gouya, E. Raffray, M. Pithon, J.-F. Stalder, J.-M. Nguyen and S. Barbarot

      Version of Record online: 13 JUL 2016 | DOI: 10.1111/bjd.14600

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      What's already known about this topic?

      • Erythropoietic protoporphyria (EPP) is a metabolic disorder, characterized by photosensitivity.
      • Avoidance of sun exposure is recommended but some patients reported a paradoxical improvement of symptoms with sun exposure.

      What does this study add?

      • The results support the hypothesis of an acquired solar tolerance phenomenon in EPP.
      • The benefit of natural progressive sun exposure for patients with EPP is proposed.
  10. Book Reviews

  11. Medical Dermatology

    1. Primary care-based screening for cardiovascular risk factors in patients with psoriasis

      M.K. Rutter, K. Kane, M. Lunt, L. Cordingley, A. Littlewood, H.S. Young, C.A. Chew-Graham, R. Hilton, D.P.M. Symmons and C.E.M. Griffiths

      Version of Record online: 12 JUL 2016 | DOI: 10.1111/bjd.14557

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      What's already known about this topic?

      • Several studies have suggested that patients with psoriasis have a greater number of risk factors for cardiovascular disease (CVD) and a higher risk for vascular events compared with the general population.
      • However, the prevalence data used to support systematic CVD risk factor screening in psoriasis have been limited by selection bias, inappropriate choice of control groups or reliance on risk factors measured for other clinical reasons.

      What does this study add?

      • Cardiovascular risk factor screening of primary care-based adults with psoriasis identified a high proportion of patients (i) at high CVD risk, (ii) with screen-detected risk factors and (iii) with suboptimally managed known risk factors.
      • These findings need to be considered alongside reports that detected limited responses of clinicians to identified risk factors before universal CVD screening can be recommended.
  12. Translational Research

    1. The spectrophotometrical analysis of rhododendrol-induced leucoderma using a novel multispectral camera

      M. Inoue, K. Kikuchi, A. Watabe, K. Yamasaki and S. Aiba

      Version of Record online: 10 JUL 2016 | DOI: 10.1111/bjd.14548

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      What's already known about this topic?

      • Rhododendrol-induced leucoderma (RDIL) is different from vitiligo vulgaris (VV) in that RDIL lesions exhibit incomplete depigmentation.
      • Most patients recover pigmentation following the discontinuation of use of cosmetics containing rhododendrol.

      What does this study add?

      • Using a novel multispectral camera, this study quantitatively demonstrated the difference in loss of pigmentation that occurs in RDIL and VV lesions and also showed repigmentation following the discontinuation of use of cosmetics containing rhododendrol.

      What is the translational message?

      • This approach can be applied in various clinical dermatology settings such as the evaluation of erythema, the discrimination between melanocytic lesion and haemorrhage, and evaluation of the efficacy of laser therapy or cosmetic treatment targeting skin colour.
  13. Medical Dermatology

    1. You have full text access to this OnlineOpen article
      Low- and high-risk human papillomavirus genotype infections in intra-anal warts in HIV-positive men who have sex with men

      M.L. Siegenbeek van Heukelom, O. Richel, H.J.C. de Vries, M.M. van de Sandt, S. Beck, H.A.M. van den Munckhof, E.C. Pirog, M.N.C. de Koning, J.M. Prins and K.D. Quint

      Version of Record online: 6 JUL 2016 | DOI: 10.1111/bjd.14567

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      What is already known about this topic?

      • Intra-anal warts in HIV-positive men who have sex with men can contain regions of high-grade anal intraepithelial neoplasia (AIN).
      • Individual components of high-grade AIN are caused by single human papillomavirus (HPV) genotype infections.

      What does this study add?

      • Low-grade AIN lesions can be caused by high-risk HPV genotypes and vice versa.
      • Positive p16 immunostaining identifies AIN lesions caused by high-risk HPV types.
  14. Research Letters

    1. Interleukin-17 and interleukin-23 regulate Langerhans cell migration

      L.H. Eaton, R.J. Dearman, I. Kimber and C.E.M. Griffiths

      Version of Record online: 5 JUL 2016 | DOI: 10.1111/bjd.14541

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  15. Case Reports

    1. In vivo reflectance confocal microscopy characterization of silver deposits in localized cutaneous argyria

      P. García-Martínez, D. López Aventín, S. Segura, I. Gómez-Martín, J. Lloreta, J. Ibáñez, J.J. Elvira and R.M. Pujol

      Version of Record online: 5 JUL 2016 | DOI: 10.1111/bjd.14571

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  16. Research Letters

    1. Inclusion and exclusion criteria in phase III trials with systemic agents in psoriasis: the external validity of drug development

      N. Kirsten, C. Bulai Livideanu, M.A. Richard, M.P. Konstantinou, A. Khemis, C. Balluteaud, C. Goujon, M. Beylot-Barry, C. Paul and for the French Psoriasis Research Group

      Version of Record online: 5 JUL 2016 | DOI: 10.1111/bjd.14622

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  17. Systematic Reviews

    1. Prevalence and odds of Staphylococcus aureus carriage in atopic dermatitis: a systematic review and meta-analysis

      J.E.E. Totté, W.T. van der Feltz, M. Hennekam, A. van Belkum, E.J. van Zuuren and S.G.M.A. Pasmans

      Version of Record online: 5 JUL 2016 | DOI: 10.1111/bjd.14566

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      What's already known about this topic?

      • Staphylococcus aureus colonizes the skin of patients with atopic dermatitis.

      What does this study add?

      • For the first time, data on S. aureus colonization in atopic dermatitis are systematically summarized showing an increased risk of colonization of lesional skin, nonlesional skin and the nose in patients vs. healthy controls.
  18. General Dermatology

    1. Alopecia areata and health-related quality of life: a systematic review and meta-analysis

      F. Rencz, L. Gulácsi, M. Péntek, N. Wikonkál, P. Baji and V. Brodszky

      Version of Record online: 2 JUL 2016 | DOI: 10.1111/bjd.14497

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      What's already known about this topic?

      • A number of studies using various measures have shown that alopecia areata reduces health-related quality of life.
      • No generic or dermatology-specific quality-of-life instrument has yet been validated in alopecia areata.

      What does this study add?

      • Comparing patients with AA with the general population, the most significantly impaired domains of health status are role-emotional, mental health and vitality.
      • Wearing a wig has a positive impact, while scalp involvement, anxiety and depression have a negative impact on quality of life.
    2. Frontal fibrosing alopecia: possible association with leave-on facial skin care products and sunscreens; a questionnaire study

      N. Aldoori, K. Dobson, C.R. Holden, A.J. McDonagh, M. Harries and A.G. Messenger

      Version of Record online: 30 JUN 2016 | DOI: 10.1111/bjd.14535

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      What's already known about this topic?

      • Frontal fibrosing alopecia (FFA) is an inflammatory scarring alopecia that mainly involves the frontal and frontal/temporal hairline and eyebrows. The histopathology is identical to that of lichen planopilaris.
      • FFA mainly affects postmenopausal women although it also occurs in younger women and occasionally in men.
      • First reported in 1994, FFA remained rare during the 1990s but has become increasingly common in the last 10–15 years.

      What does this study add?

      • Leave-on facial skin care products are implicated in the aetiology of FFA.
      • It is suggested that sunscreen chemicals play a causative role.
      • It is suggested that there is an increased predisposition to immune-mediated disease in FFA.
  19. Review Articles

    1. Heat urticaria: a revision of published cases with an update on classification and management

      E. Pezzolo, A. Peroni, P. Gisondi and G. Girolomoni

      Version of Record online: 30 JUN 2016 | DOI: 10.1111/bjd.14543

      What's already known about this topic?

      • Heat urticaria (HU) is a rare form of inducible urticaria, which can present with different subtypes.
      • Treatment options still need better definition.

      What does this study add?

      • A comprehensive review of all published cases allowed a detailed analysis of clinical features.
      • More than 80% of patients affected by HU were young women with an immediate reaction.
      • Most of the patients with immediate-type HU achieved partial or complete remission with heat desensitization alone.
      • Pharmacological intervention included nonsedating H1 and H2 antihistamines as well as omalizumab.
  20. Medical Dermatology

    1. Comparison of screening questionnaires to identify psoriatic arthritis in a primary-care population: a cross-sectional study

      L.C. Coates, L. Savage, R. Waxman, A.R. Moverley, S. Worthington and P.S. Helliwell

      Version of Record online: 30 JUN 2016 | DOI: 10.1111/bjd.14604

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      What's already known about this topic?

      • National Institute for Health and Care Excellence guidance for management of psoriasis recommends annual screening for patients to identify psoriatic arthritis.
      • Many screening questionnaires are available but there is little evidence comparing them.
      • A new screening questionnaire (CONTEST) was developed using the most discriminative items from existing questionnaires after the CONTEST study identified increasing positive predictive value with positivity on multiple questionnaires in secondary care.

      What does this study add?

      • This study confirms that the Psoriasis Epidemiology Screening Tool and CONTEST questionnaires can be used to identify psoriatic arthritis in patients in primary care.
      • It suggests that lower cut points on these questionnaires optimize sensitivity and specificity.
  21. Letters to the Editor

    1. Glycaemic control in patients with diabetes and concomitant psoriasis

      G. Shalom, J. Shapiro, J. Dreiher, A. Nathan, T. Freud, D. Comaneshter, A. Horev, R. Khoury, S. Vinker and A.D. Cohen

      Version of Record online: 30 JUN 2016 | DOI: 10.1111/bjd.14545

  22. Research Letters

  23. General Dermatology

    1. Dermoscopy, a useful tool for general practitioners in melanoma screening: a nationwide survey

      P. Chappuis, G. Duru, O. Marchal, P. Girier, S. Dalle and L. Thomas

      Version of Record online: 30 JUN 2016 | DOI: 10.1111/bjd.14495

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      What's already known about this topic?

      • National surveys regarding the use of dermoscopy by general practitioners have been conducted mainly in Australia and Italy.
      • The use by French general practitioners has never previously been described, despite dermoscopy being a useful tool for the diagnosis of melanoma.

      What does this study add?

      • Dermoscopy provides new and important diagnostic criteria to diagnose melanoma more accurately and reliably.
      • We report herein the first study evaluating the use of dermoscopy by general practitioners in France.
      • We aimed to analyse the current use, opinions, teaching modalities and research in this field.
    2. TOX expression in cutaneous T-cell lymphomas: an adjunctive diagnostic marker that is not tumour specific and not restricted to the CD4+ CD8 phenotype

      A.M.R. Schrader, P.M. Jansen and R. Willemze

      Version of Record online: 29 JUN 2016 | DOI: 10.1111/bjd.14508

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      What's already known about this topic?

      • TOX is associated with development of CD4+ CD8 T cells in the thymus, but is suppressed in mature CD4+ T cells.
      • TOX is aberrantly expressed in mycosis fungoides and Sézary syndrome.

      What does this study add?

      • TOX is expressed by various types of cutaneous T-cell lymphoma (CTCL), but also – although less strongly and less frequently – by reactive T cells in benign inflammatory dermatoses.
      • Expression of TOX is not restricted to CD4+ CD8 (neoplastic) T cells.
      • TOX expression may contribute to the diagnosis of CTCL.
  24. Letters to the Editor

  25. Translational Research

    1. Antimelanogenic effects of luteolin 7-sulfate isolated from Phyllospadix iwatensis Makino

      J.Y. Kwak, J.K. Seok, H.-J. Suh, Y.-H. Choi, S.S. Hong, D.S. Kim and Y.C. Boo

      Version of Record online: 28 JUN 2016 | DOI: 10.1111/bjd.14496

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      What's already known about this topic?

      • Previous efforts to develop antimelanogenic agents have investigated the activity of various plants against mushroom tyrosinase. However, this approach is not appropriate because of the inherent differences between mushroom and human tyrosinases.

      What does this study add?

      • This study screened 50 marine plants for human tyrosinase inhibitory effects and found that Phyllospadix iwatensis extract and its constituent, luteolin 7-sulfate, inhibited human tyrosinase activity and attenuated melanin synthesis in B16/F10 cells and human epidermal melanocytes.

      What is the translational message?

      • Marine plants have attracted attention as under-researched resources for bioactive compounds, and this study demonstrates that luteolin 7-sulfate isolated from Phyllospadix iwatensis Makino, a kind of seagrass, is a more potent and safer inhibitor of cellular melanin synthesis than luteolin.
      • If these findings are confirmed by clinical studies, the flavonoid sulfate may be useful for the control of unwanted skin pigmentation due to excessive melanin synthesis.
  26. Book Reviews

  27. Clinical Trials

    1. You have full text access to this OnlineOpen article
      A randomized, double-blind, phase III, multicentre study to evaluate the safety and efficacy of BF-200 ALA (Ameluz®) vs. placebo in the field-directed treatment of mild-to-moderate actinic keratosis with photodynamic therapy (PDT) when using the BF-RhodoLED® lamp

      U. Reinhold, T. Dirschka, R. Ostendorf, R. Aschoff, C. Berking, W.G. Philipp-Dormston, S. Hahn, K. Lau, A. Jäger, B. Schmitz, H. Lübbert and R.-M. Szeimies

      Version of Record online: 25 JUN 2016 | DOI: 10.1111/bjd.14498

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      What's already known about this topic?

      • BF-200 ALA is an exceptionally effective, well-tolerated drug for photodynamic therapy (PDT) of actinic keratosis (AK).
      • AK affects extended skin areas and requires field-directed treatment.
      • PDT with BF-200 ALA is most effective with narrowband light-emitting diode lamps.

      What does this study add?

      • This study evaluates the safety and efficacy of BF-200 ALA when used together with the BF-RhodoLED lamp for the field-directed treatment of AK.
      • This trial demonstrates a strong rejuvenation effect of PDT with BF-200 ALA on an entire treatment field.
      • Our results show that field-directed therapy with BF-200 ALA and BF-RhodoLED lamp is highly effective and well tolerated for multiple mild-to-moderate AK lesions.
  28. Letters to the Editor

  29. Medical Dermatology

    1. Body mass index predicts discontinuation due to ineffectiveness and female sex predicts discontinuation due to side-effects in patients with psoriasis treated with adalimumab, etanercept or ustekinumab in daily practice: a prospective, comparative, long-term drug-survival study from the BioCAPTURE registry

      J. Zweegers, J.M.P.A. van den Reek, P.C.M. van de Kerkhof, M.E. Otero, A.L.A. Kuijpers, M.I.A. Koetsier, W.P. Arnold, M.A.M. Berends, L. Weppner-Parren, P.M. Ossenkoppele, M.D. Njoo, J.M. Mommers, P.P.M. van Lümig, R.J.B. Driessen, W. Kievit and E.M.G.J. de Jong

      Version of Record online: 25 JUN 2016 | DOI: 10.1111/bjd.14552

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      What's already known about this topic?

      • Drug survival of biologics for psoriasis has been analysed, but few publications used prospective multicentre daily-practice data.
      • These studies found that ustekinumab had the highest confounder-corrected overall drug survival, but they did not split survival analysis for the different biologics or for different reasons of discontinuation.
      • Different predictors for overall drug survival were found in prospective and retrospective studies.

      What does this study add?

      • This study reports on a longer period of drug survival than previous studies.
      • Ustekinumab has a higher confounder-corrected drug survival and higher survival for discontinuation due to ineffectiveness and side-effects than adalimumab and etanercept.
      • Higher body mass index (BMI) predicts discontinuation due to ineffectiveness in etanercept and ustekinumab, and female sex is a consistent predictor for discontinuation due to side-effects in all three biologics.
  30. Book Reviews

  31. Clinical Trials

    1. You have full text access to this OnlineOpen article
      A prospective phase III, randomized, double-blind, placebo-controlled study of brodalumab in patients with moderate-to-severe plaque psoriasis

      K.A. Papp, K. Reich, C. Paul, A. Blauvelt, W. Baran, C. Bolduc, D. Toth, R.G. Langley, J. Cather, A.B. Gottlieb, D. Thaçi, J.G. Krueger, C.B. Russell, C.E. Milmont, J. Li, P.A. Klekotka, G. Kricorian and A. Nirula

      Version of Record online: 23 JUN 2016 | DOI: 10.1111/bjd.14493

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      What's already known about this topic?

      • Anti-interleukin (anti-IL)-17 receptor A and anti-IL-17A antibodies have been shown to be efficacious in treating patients with moderate-to-severe plaque psoriasis.

      What does this study add?

      • This study further demonstrates that brodalumab therapy in patients with moderate-to-severe plaque psoriasis results in a high degree of complete skin clearance.
      • This study also further elucidates the safety profile of brodalumab.
  32. Research letters

    1. Extending the spectrum of AKT1 mosaicism: not just the Proteus syndrome

      S. Polubothu, L. Al-Olabi, L. Wilson, W.K. Chong and V.A. Kinsler

      Version of Record online: 23 JUN 2016 | DOI: 10.1111/bjd.14478

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  33. Letters to the Editor

  34. Translational Research

    1. Epidermal filaggrin deficiency mediates increased systemic T-helper 17 immune response

      C.M. Bonefeld, T.H. Petersen, J. Bandier, C. Agerbeck, A. Linneberg, K. Ross-Hansen, S. Stender, P.B. Szecsi, J.D. Johansen, C. Geisler and J.P. Thyssen

      Version of Record online: 23 JUN 2016 | DOI: 10.1111/bjd.14570

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      What's already known about this topic?

      • An increased level of T-helper (Th)17 cells is found in the skin of flaky tail mice.
      • Th17 cells seem to be involved in the pathogenesis of atopic dermatitis.

      What does this study add?

      • We show that loss-of-function mutations in the filaggrin gene could be a driver of increased frequency of peripheral Th17 cells in both humans and mice.
      • The increase in Th17 cells is most likely mediated by extrinsic factors.

      What is the translational message?

      • Atopic dermatitis owing to filaggrin deficiency appears to have a Th17 profile.
      • Future experiments may examine whether anti-interleukin-17 medicaments may reduce disease severity.
  35. Research Letters

  36. General Dermatology

    1. Preoperative prediction of histopathological outcome in basal cell carcinoma: flat surface and multiple small erosions predict superficial basal cell carcinoma in lighter skin types

      I. Ahnlide, I. Zalaudek, F. Nilsson, M. Bjellerup and K. Nielsen

      Version of Record online: 23 JUN 2016 | DOI: 10.1111/bjd.14499

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      What's already known about this topic?

      • Superficial basal cell carcinomas (sBCCs) can be treated nonsurgically, but a correct diagnosis is crucial.
      • sBCCs exhibit certain macroscopic and dermoscopic characteristics.
      • Few studies have evaluated the accuracy of preoperative prediction of subtype of BCC in a routine clinical setting.

      What does this study add?

      • Mandatory use of dermoscopy improves the preoperative prediction of sBCC.
      • A flat surface and multiple small erosions are the best predictors for sBCC in lighter skin types.
  37. Systematic Reviews

    1. Interventions for hirsutism excluding laser and photoepilation therapy alone: abridged Cochrane systematic review including GRADE assessments

      E.J. van Zuuren and Z. Fedorowicz

      Version of Record online: 23 JUN 2016 | DOI: 10.1111/bjd.14486

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      What's already known about this topic?

      • Hirsutism is a common disorder with a major impact on quality of life.
      • Polycystic ovary syndrome is the most frequent cause of hirsutism.
      • It is unclear which treatments are safe and which are the most effective.

      What does this study add?

      • There is evidence that oral contraceptives, flutamide 250 mg twice daily and spironolactone 100 mg daily are effective and safe.
      • There was inconsistency of results for the effectiveness of finasteride and gonadotropin-releasing analogues.
      • Metformin appeared to be ineffective for the treatment of hirsutism.
  38. Book Reviews

  39. Letters to the Editor

  40. Medical Dermatology

    1. Both low circulating insulin-like growth factor-1 and high-density lipoprotein cholesterol are associated with hair loss in middle-aged women

      R. Noordam, D.A. Gunn, K. van Drielen, G. Westgate, P.E. Slagboom, A.J.M. de Craen and D. van Heemst

      Version of Record online: 23 JUN 2016 | DOI: 10.1111/bjd.14529

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      What's already known about this topic?

      • Multiple biomarkers have been associated with female hair loss, but studies have shown inconsistent results.

      What does this study add?

      • We identified low high-density lipoprotein cholesterol and low insulin-like growth factor-1 as independent risk factors for female hair loss.
      • When the data are replicated, pathways leading to female hair loss can be identified as potential treatment targets.
  41. Case Reports

    1. Segmental basal cell naevus syndrome caused by an activating mutation in smoothened

      Z. Khamaysi, R. Bochner, M. Indelman, L. Magal, E. Avitan-Hersh, O. Sarig, E. Sprecher and R. Bergman

      Version of Record online: 20 JUN 2016 | DOI: 10.1111/bjd.14425

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      What's already known about this topic?

      • Mutations in smoothened (SMO) have been previously reported in acquired basal cell carcinomas but not in basal cell naevus syndrome (BCNS).

      What does this study add?

      • A gain-of-function mutation in SMO was demonstrated in the type 1 mosaic form of BCNS, which further expands the understanding of this syndrome.
  42. Epidemiology

    1. Association between psoriasis and inflammatory bowel disease: a Danish nationwide cohort study

      A. Egeberg, L. Mallbris, R.B. Warren, H. Bachelez, G.H. Gislason, P.R. Hansen and L. Skov

      Version of Record online: 20 JUN 2016 | DOI: 10.1111/bjd.14528

      What's already known about this topic?

      • Co-occurrence of psoriasis and inflammatory bowel disease (IBD) has been described, but data are inconsistent.

      What does this study add?

      • In a nationwide cohort study, we found a bidirectional relationship between psoriasis and IBD.
  43. Letters to the Editor

    1. Epstein–Barr virus-associated B-cell lymphoproliferative disorder in a patient with Sézary syndrome treated by methotrexate

      S. Ingen-Housz-Oro, N. Ortonne, N. Cordel, J. Moroch, G. Do-Pham, M.H. Delfau, C. Haioun and O. Chosidow

      Version of Record online: 20 JUN 2016 | DOI: 10.1111/bjd.14602

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  44. Research Letters

  45. Research letters

  46. Case Reports

    1. Worsening of calcinosis cutis with teriparatide treatment in two osteoporotic patients

      A.F. Echeverri, F.E. Ospina, C.A. Cañas, A. Agualimpia, J.P. Suso, G.J. Tobón and F. Bonilla-Abadía

      Version of Record online: 20 JUN 2016 | DOI: 10.1111/bjd.14550

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      What's already known about this topic?

      • After searching the literature with the medical subject heading terms ‘calcinosis cutis’, ‘teriparatide’ and ‘complications’, we found no known literature on this topic.

      What does this study add?

      • We report two cases of systemic autoimmune disease with concomitant calcinosis cutis that worsened on treatment with teriparatide.
      • We alert practitioners to the possible side-effects of teriparatide in patients with dermatomyositis and CREST syndrome who have calcinosis cutis.
  47. Research Letters

    1. The new Cutaneous Lymphoma International Prognostic index (CLIPi) for early mycosis fungoides failed to identify prognostic groups in a cohort of Spanish patients

      J. Sanz-Bueno, D. Lora, V. Monsálvez, L. Maroñas-Jiménez, C. Postigo, J.L. Rodríguez- Peralto and P.L. Ortiz-Romero

      Version of Record online: 20 JUN 2016 | DOI: 10.1111/bjd.14559

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    2. Increased airway inflammation in patients with psoriasis

      G. Damiani, A. Radaeli, A. Olivini, P. Calvara-Pinton and M. Malerba

      Version of Record online: 20 JUN 2016 | DOI: 10.1111/bjd.14546

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  48. Letters to the Editor

    1. Discrepant mutational status between naevi and melanomas in naevus-associated melanomas: about mutation-specific immunohistochemistry: reply from the authors

      D. Shitara, G. Tell-Martí, C. Badenas, M.M.S.S. Enokihara, L. Alós, A.B. Larque, N. Michalany, J.A. Puig-Butille, C. Carrera, J. Malvehy, S. Puig and E. Bagatin

      Version of Record online: 16 JUN 2016 | DOI: 10.1111/bjd.14613

  49. Case Reports

    1. Endothelial chimerism in chronic sclerotic-type chronic graft-versus-host disease (GVHD) and GVHD-associated angiomatosis

      B.H. Kaffenberger, E. Zhang, J.R. Duncan, S. Jaglowski, R.B. Klisovic, S.M. Devine, H.K. Wong and A.A. Gru

      Version of Record online: 10 JUN 2016 | DOI: 10.1111/bjd.14484

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      What's already known about this topic?

      • Graft-versus-host disease-associated angiomatosis (GVHD-AA) is a recently described uncommon presentation of endothelial proliferation developing exclusively within areas of sclerotic-type GVHD, resulting in friable capillary proliferations.
      • Transplanted human bone marrow has recently been shown to contribute to normal vascular endothelium in female patients with sex-mismatched donors.

      What does this study add?

      • Based on two female patients with sex-mismatched donors, using fluorescence in situ hybridization we show that donor endothelial cells are present in GVHD-AA.
      • While endothelial chimerism has been previously documented following transplantation, this report documents for the first time the occurrence of a benign neoplastic growth in relationship to a form of chronic GVHD.
  50. Research Letters

    1. You have full text access to this OnlineOpen article
  51. Epidemiology

    1. Vitamin D levels and atopic eczema in infancy and early childhood in Norway: a cohort study

      T.L. Berents, K.C. Lødrup Carlsen, P. Mowinckel, L. Sandvik, H.O. Skjerven, L.B. Rolfsjord, B. Kvenshagen, J.O.G. Hunderi, M. Bradley, A. Lieden, K.-H. Carlsen, P.M. Thorsby and P. Gjersvik

      Version of Record online: 9 JUN 2016 | DOI: 10.1111/bjd.14537

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      What's already known about this topic?

      • Epidemiological and clinical data suggest that vitamin D (vitD) may be of importance in atopic eczema (AE).
      • Results from studies on the association between vitD levels and AE are conflicting.

      What does this study add?

      • In a cohort of young children living in Norway, vitD levels were not associated with AE.
  52. Case Reports

    1. CDKN2A mutations with p14 loss predisposing to multiple nerve sheath tumours, melanoma, dysplastic naevi and internal malignancies: a case series and review of the literature

      M.R. Sargen, S.L. Merrill, E.Y. Chu and K.L. Nathanson

      Version of Record online: 8 JUN 2016 | DOI: 10.1111/bjd.14485

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      What's already known about this topic?

      • CDKN2A mutations with p16 loss predispose to melanoma and pancreatic cancer.

      What does this study add?

      • This is the first report of a family with a splice-site mutation resulting in loss of p16INK4 and p14ARF to present with multiple nerve sheath tumours.
      • We provide cancer screening recommendations for patients with mutations in CDKN2A resulting in loss of both p14 and p16, which predispose patients to a variety of carcinomas, sarcomas and brain tumours.
  53. Letters to the Editor

  54. Case Reports

    1. Swamp cancer: a case of human pythiosis and review of the literature

      R.E. Hilton, K. Tepedino, C.J. Glenn and K.L. Merkel

      Version of Record online: 7 JUN 2016 | DOI: 10.1111/bjd.14520

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      What's already known about this topic?

      • Pythiosis is an endemic infectious disease in Thailand associated with high morbidity and mortality; however, it is rare in North America.
      • Very few cases of cutaneous disease have been reported in the literature.

      What does this study add?

      • We present a case of pythiosis in North America, and review the previously reported cases of cutaneous pythiosis.
      • Our case highlights the importance of increased awareness of this infectious disease in order to facilitate early recognition and treatment.
  55. Letters to the Editor

    1. Response to ‘Darier disease in Israel: combined evaluation of genetic and neuropsychiatric aspects’: reply from the authors

      R.P. Dodiuk-Gad, E. Cohen-Barak, M. Khayat, H. Milo, L. Amariglio-Diskin, N. Danial-Faran, M. Sah, M. Ziv, A. Shani-Adir, B. Amichai, A. Zlotogorski, Z. Borochowitz, D. Rozenman and S. Shalev

      Version of Record online: 7 JUN 2016 | DOI: 10.1111/bjd.14544

  56. Research Letters

    1. Comparing the effect of bleach and water baths on skin barrier function in atopic dermatitis: a split-body randomized controlled trial

      V.Y. Shi, N. Foolad, J.N. Ornelas, L.A. Hassoun, G. Monico, N. Takeda, S. Saric, N. Prakash, L.F. Eichenfield and R.K. Sivamani

      Version of Record online: 7 JUN 2016 | DOI: 10.1111/bjd.14483

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  57. Research letters

  58. Clinical Trials

    1. Phase II multicentre trial of oral quisinostat, a histone deacetylase inhibitor, in patients with previously treated stage IB–IVA mycosis fungoides/Sézary syndrome

      F. Child, P.L. Ortiz-Romero, R. Alvarez, M. Bagot, R. Stadler, M. Weichenthal, R. Alves, P. Quaglino, M. Beylot-Barry, R. Cowan, L.J. Geskin, A. Pérez-Ferriols, P. Hellemans, Y. Elsayed, C. Phelps, A. Forslund, M. Kamida and P.L. Zinzani

      Version of Record online: 2 JUN 2016 | DOI: 10.1111/bjd.14427

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      What's already known about this topic?

      • Histone deacetylase inhibitors (HDAC-Is) have been associated with significant clinical activity in different neoplastic disorders. Vorinostat and romidepsin have been approved by the U.S. Food and Drug Administration for treatment of cutaneous T-cell lymphoma (CTCL).
      • Quisinostat is a hydroxamate, second-generation, orally available pan-HDAC-I.

      What does this study add?

      • Oral quisinostat 12 mg three times weekly is active in the treatment of patients with relapsed or refractory CTCL, and has an acceptable safety profile.
      • There was a low global response rate of 8% vs. a cutaneous response rate of 24%.
      • Combination therapy of quisinostat with other novel agents may be appropriate in patients who relapse following current conventional approaches.
  59. Research Letters

  60. General Dermatology

    1. In vivo confocal microscopy efficacy assessment of daylight photodynamic therapy in actinic keratosis patients

      S.M. Seyed Jafari, T. Timchik and R.E. Hunger

      Version of Record online: 30 MAY 2016 | DOI: 10.1111/bjd.14517

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      What's already known about this topic?

      • Actinic keratosis (AK) is the most common precancerous cutaneous lesion.
      • Reflectance confocal microscopy (RCM) is a noninvasive diagnostic technique with an acceptable sensitivity and specificity for AK.

      What does this study add?

      • In vivo RCM technology might be an additional technique to monitor the efficacy of daylight photodynamic therapy for AK.
      • The atypia scoring system is an applicable technique to facilitate the use of RCM technology as an additional monitoring method.
  61. Translational Research

    1. Microarray study reveals a transforming growth factor-β-dependent mechanism of fibrosis in discoid lupus erythematosus

      C. Solé, M. Gimenez-Barcons, B. Ferrer, J. Ordi-Ros and J. Cortés-Hernández

      Version of Record online: 29 MAY 2016 | DOI: 10.1111/bjd.14539

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      What's already known about this topic?

      • Discoid lupus erythematosus (DLE) lesions lead to fibrotic changes, whereas subacute cutaneous lupus erythematosus (SCLE) lesions do not.
      • The mechanism of fibrosis formation is currently unknown.

      What does this study add?

      • The first microarray study between the two types of lupus, showing a significantly high-intensity T-regulatory-cell response in DLE that is sustained over time.
      • Discoid cutaneous lupus lesions express a hyperactivated transforming growth factor-β pathway that contributes to the development of fibrosis.

      What is the translational message?

      • This study provides the first proposed mechanism for the formation and perpetuation of fibrosis in DLE lesions based on the differential molecular patterns found between DLE and SCLE skin biopsies.
      • The results provided allow a better understanding of the pathogenesis of DLE skin lesions and open a new field for the research and development of specific treatments.
  62. Research Letters

    1. Ketoconazole does not decrease fungal amount in patients with seborrhoeic dermatitis

      M.B. Zani, R.C. Soares, A.C.B.B. Arruda, L.H.F. de Arruda and L.C. Paulino

      Version of Record online: 29 MAY 2016 | DOI: 10.1111/bjd.14501

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  63. Medical Dermatology

    1. Diagnostic patch testing following tuberculosis-associated cutaneous adverse drug reactions induces systemic reactions in HIV-infected persons

      R.J. Lehloenya, G. Todd, J. Wallace, M.R. Ngwanya, R. Muloiwa and K. Dheda

      Version of Record online: 26 MAY 2016 | DOI: 10.1111/bjd.14492

      What's already known about this topic?

      • HIV-infected persons are predisposed to frequent and severe cutaneous adverse drug reactions (CADRs).
      • The utility of patch testing in the diagnosis of CADR varies with the type of CADR and the offending drug.
      • Patch testing is not well defined for tuberculosis-associated CADR in HIV-infected persons.

      What does this study add?

      • In HIV-infected persons with tuberculosis-associated CADR, patch testing reactions to first-line antituberculosis drugs seem to be associated with systemic features, not localized reactions.
  64. Research Letters

    1. Is a punch biopsy reliable in subtyping basal cell carcinoma? A systematic review

      D.J. Kadouch, A. van Haersma de With, J. Limpens, A.C. van der Wal, A. Wolkerstorfer, M.W. Bekkenk and M.A. de Rie

      Version of Record online: 26 MAY 2016 | DOI: 10.1111/bjd.14458

  65. Epidemiology

    1. Predictive factors of self-reported hand eczema in adult Danes: a population-based cohort study with 5-year follow-up

      N.G. Heede, J.P. Thyssen, B.H. Thuesen, A. Linneberg and J.D. Johansen

      Version of Record online: 24 MAY 2016 | DOI: 10.1111/bjd.14476

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      What's already known about this topic?

      • Atopic dermatitis (AD), female sex, contact sensitization and wet work are known risk factors for hand eczema.
      • Knowledge about predictive factors of hand eczema in the adult general population is limited.

      What does this study add?

      • A history of AD predicts both incident and persistent hand eczema in adults.
      • Filaggrin gene (FLG) null mutations strongly predict persistent hand eczema, but the association with incident hand eczema in adults is nonsignificant.
      • Contact sensitization is significantly associated with persistent hand eczema, also in participants without AD.
  66. Letters to the Editor

  67. Research Letters

    1. Trichoscopy as an additional tool for the differential diagnosis of tinea capitis: a prospective clinical study

      A. Brasileiro, S. Campos, J. Cabete, C. Galhardas, A. Lencastre and V. Serrão

      Version of Record online: 23 MAY 2016 | DOI: 10.1111/bjd.14413

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  68. Research letters

    1. Risk of bias does not differ between full papers and letters reporting dermatological randomized controlled trials

      D.N. Chauhan, S.R. Wilkes, S. Ratib, E. Doney, J.M. Batchelor, N.K. Rogers and H.C. Williams

      Version of Record online: 22 MAY 2016 | DOI: 10.1111/bjd.14455

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  69. Research Letters

    1. Parkinson disease and multiple sclerosis are not associated with autoantibodies against structural proteins of the dermal–epidermal junction

      A. Recke, A. Oei, F. Hübner, K. Fechner, J. Graf, J. Hagenah, C. May, D. Woitalla, A. Salmen, D. Zillikens, R. Gold, W. Schlumberger and E. Schmidt

      Version of Record online: 18 MAY 2016 | DOI: 10.1111/bjd.14538

  70. Letters to the Editor

    1. Bier anaemic spots, cyanosis with urticaria-like eruption (BASCULE) syndrome: a new entity?

      D. Bessis, É. Jeziorski, V. Rigau, P. Pralong and V. Pallure

      Version of Record online: 18 MAY 2016 | DOI: 10.1111/bjd.14589

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  71. Translational Research

    1. Zinc finger protein A20 is involved in the antipsoriatic effect of calcipotriol

      X. Liu, Y. Liu, M. Xu, J. Li, X. Teng, H. Cheng and Y. Xia

      Version of Record online: 14 MAY 2016 | DOI: 10.1111/bjd.14481

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      What's already known about this topic?

      • TNFAIP3 (encoding A20) polymorphisms are associated with the susceptibility to psoriasis.
      • A20 exhibits an anti-apoptotic effect on various types of cells, and regulates nuclear factor kappa B (NF-κB) activation.
      • Calcipotriol ameliorates psoriasis through inducing apoptosis of keratinocytes.

      What does this study add?

      • A20 expression increases in keratinocytes under psoriatic inflammation.
      • Calcipotriol suppresses A20 expression in psoriatic tissues or keratinocytes.
      • Under psoriatic inflammation, NF-κB inhibition occurs in keratinocytes with A20 downregulation induced by calcipotriol.
      • Calcipotriol promotes the binding of A20 to ring finger protein 114 (RNF114) and A20-binding inhibitor of NF-κB-1 (ABIN-1) partners, which are known to downregulate the NF-κB pathway.

      What is the translational message?

      • The A20 pathway may be a therapeutic target for treating psoriasis.
  72. Research letters

  73. General Dermatology

    1. You have full text access to this OnlineOpen article
      Psychometric properties of the Itch Numeric Rating Scale in patients with moderate-to-severe plaque psoriasis

      A.B. Kimball, A.N. Naegeli, E. Edson-Heredia, C.-Y. Lin, C. Gaich, E. Nikaï, K. Wyrwich and G. Yosipovitch

      Version of Record online: 8 MAY 2016 | DOI: 10.1111/bjd.14464

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      What's already known about this topic?

      • Itching is a profoundly distressing symptom for many patients with psoriasis, but has not been rigorously studied using validated tools for this condition.
      • The Itch Numeric Rating Scale is a single-item instrument that assesses the severity of itch due to psoriasis.

      What does this study add?

      • The Itch Numeric Rating Scale demonstrated sufficient reliability, validity and responsiveness, and appropriate interpretation standards for evaluating change over time in itch severity among patients with moderate-to-severe plaque psoriasis.
  74. Review Articles

    1. You have full text access to this OnlineOpen article
      Development of core outcome sets in hidradenitis suppurativa: systematic review of outcome measure instruments to inform the process

      J.R. Ingram, S. Hadjieconomou and V. Piguet

      Version of Record online: 2 MAY 2016 | DOI: 10.1111/bjd.14475

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      What's already known about this topic?

      • The recent hidradenitis suppurativa (HS) Cochrane review identified heterogeneity of outcome measure instruments as an important obstacle in the design of future HS trials.
      • The Harmonising Outcome Measures for Eczema (HOME) initiative provides a roadmap for developing a core outcomes set in HS.

      What does this study add?

      • Twenty-seven of the 30 outcome measure instruments used in HS randomized controlled trials are not supported by any formal validation data.
      • Where available, validation evidence is generally of relatively low methodological quality, or remains incomplete, and so no instruments can be fully recommended currently.
  75. General Dermatology

    1. N-Acyl ethanolamide and eicosanoid involvement in irritant dermatitis

      A.C. Kendall, S.M. Pilkington, G. Sassano, L.E. Rhodes and A. Nicolaou

      Version of Record online: 28 APR 2016 | DOI: 10.1111/bjd.14521

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      What's already known about this topic?

      • Bioactive lipid mediators are emerging as important players in cutaneous homeostasis and inflammation.
      • Irritant dermatitis is a considerable problem in dermatology/occupational health, and would benefit from greater understanding of the role of lipids in the skin's response to irritants.

      What does this study add?

      • Specific eicosanoid and endocannabinoid mediators contribute to the inflammatory response to the common irritant sodium lauryl sulfate but not to ultraviolet radiation challenge matched to generate comparable erythema.
      • Our findings provide insights into pathways involved in irritant dermatitis, with potential translation to novel treatments and new means for assessing contact irritants.
  76. Translational Research

    1. Serum and salivary IgG and IgA antibodies to desmoglein 3 in mucosal pemphigus vulgaris

      S. Ali, C. Kelly, S.J. Challacombe, A.N.A. Donaldson, B.S. Bhogal and J.F. Setterfield

      Version of Record online: 27 APR 2016 | DOI: 10.1111/bjd.14410

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      What's already known about this topic?

      • The use of serum to test for IgG autoantibodies to desmoglein (Dsg)3 by enzyme-linked immunosorbent assay has been well documented.
      • Salivary IgG anti-Dsg3 antibodies have been previously detected in three studies in pemphigus vulgaris (PV) and have been proposed as a diagnostic marker.

      What does this study add?

      • This study demonstrates that detection of salivary antibodies provides a practical alternative to serum in the diagnosis of PV. Salivary antibodies may also be used for the monitoring of disease activity in patients with PV.
      • Both IgG and IgA serum antibodies to Dsg3 are detected in IgG-driven PV. Further investigation is needed to understand the role of IgA in the pathogenesis of PV.

      What is the translational message?

      • The simplicity of obtaining a whole saliva sample and the demonstration that anti-Dsg3 IgG antibodies can be easily detected suggests that saliva may become a useful diagnostic screening test for PV.
      • As titres are related to disease activity, repeated noninvasive sampling offers the possibility of routine remote monitoring of disease.
    2. Common and rare CARD14 gene variants affect the antitumour necrosis factor response among patients with psoriasis

      P. Coto-Segura, D. González-Fernández, A. Batalla, J. Gómez, L. González-Lara, R. Queiro, B. Alonso, S. Iglesias and E. Coto

      Version of Record online: 25 APR 2016 | DOI: 10.1111/bjd.14461

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      What's already known about this topic?

      • Patients with psoriasis treated with antitumour necrosis factor (anti-TNF) agents (and other biological therapies) exhibit a heterogeneous response.
      • This could be explained partly by the variability in genes that encode components of immunological pathways.
      • Rare and common CARD14 variants have been linked to the risk for psoriasis, but no study about the effect on anti-TNF response has been reported.

      What does this study add?

      • Our study showed that the CARD14 rs11652075 polymorphism (Arg820Trp) was associated with the response to anti-TNF agents among patients with psoriasis.
      • The genotype that increased the risk for psoriasis was also a significant predictor of a better anti-TNF response, measured as ≥ 75% improvement in Psoriasis Area and Severity Index at week 24.

      What is the translational message?

      • Variants of the CARD14 gene (a regulator of nuclear factor-κB-mediated pathways) have been associated with the overall risk of developing psoriasis in case–control studies.
      • In this work, we show that CARD14 variants are also related to the response to anti-TNF agents.
      • If the results are confirmed by others, the analysis of this gene might help dermatologists to optimize treatment with anti-TNF biological drugs.
  77. Research Letters

    1. PSTPIP1 gene mutation in a pyoderma gangrenosum, acne and suppurative hidradenitis (PASH) syndrome

      X. Calderón-Castrat, D. Bancalari-Díaz, C. Román-Curto, A. Romo-Melgar, D. Amorós-Cerdán, L.A. Alcaraz-Mas, E. Fernández-López and J. Cañueto

      Version of Record online: 19 APR 2016 | DOI: 10.1111/bjd.14383

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  78. Letters to the Editor

  79. Translational Research

    1. IgE and FcεRI are highly expressed on innate cells in psoriasis

      K-X. Yan, Q. Huang, X. Fang, Z-H. Zhang, L. Han, K. Gadaldi, K-F. Kang, Z-Z. Zheng, J-H. Xu and N. Yawalkar

      Version of Record online: 18 APR 2016 | DOI: 10.1111/bjd.14459

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      What's already known about this topic?

      • Serum total IgE levels are elevated in patients with psoriasis.

      What does this study add?

      • The expression of IgE and FcεRI was particularly enhanced on innate cells in psoriatic lesions. The numbers of IgE+ and FcεRI+ cells in psoriatic lesions significantly decreased after treatment with ustekinumab.

      What is the translational message?

      • IgE-mediated mechanisms may perpetuate cutaneous inflammation in a subset of patients with psoriasis.
  80. Letters to the Editor

    1. Short-contact, low-dose methyl aminolaevulinate photodynamic therapy for acne vulgaris

      C. Dessinioti, S. Masouri, E. Drakaki, A. Katsambas and C. Antoniou

      Version of Record online: 18 APR 2016 | DOI: 10.1111/bjd.14460

  81. Research Letters

    1. Net-like superficial vascular malformation: clinical description and evidence for lymphatic origin

      L. Noguera-Morel, S.L. Stein, G. Xirotagaros, A. Hernández-Martín, I. de Prada, I.J. Frieden, L. Requena and A. Torrelo

      Version of Record online: 18 APR 2016 | DOI: 10.1111/bjd.14404

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  82. General Dermatology

    1. Multicentre study on inflammatory skin diseases from The International Confocal Working Group: specific confocal microscopy features and an algorithmic method of diagnosis

      M. Ardigo, C. Longo, S. Gonzalez and The International Confocal Working Group Inflammatory Skin Diseases Project

      Version of Record online: 18 APR 2016 | DOI: 10.1111/bjd.14516

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      What's already known about this topic?

      • Reflectance confocal microscopy has been used successfully for the evaluation of several inflammatory skin diseases.

      What does this study add?

      • Reflectance confocal microscopy provides features useful for diagnosis and differential diagnosis of the major inflammatory skin diseases.
      • An algorithmic method originating from multivariate analysis can be used for the diagnosis.
  83. Research letters

    1. Drug survival for azathioprine and enteric-coated mycophenolate sodium in a long-term daily practice cohort of adult patients with atopic dermatitis

      J. van der Schaft, K. Politiek, J.M.P.A. van den Reek, W. Kievit, E.M.G.J. de Jong, C.A.F.M. Bruijnzeel-Koomen, M.L.A. Schuttelaar and M.S. de Bruin-Weller

      Version of Record online: 17 APR 2016 | DOI: 10.1111/bjd.14398

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  84. Case Reports

    1. Topical sodium metabisulfite for the treatment of calcinosis cutis: a promising new therapy

      P. del Barrio-Díaz, C. Moll-Manzur, S. Álvarez-Veliz and C. Vera-Kellet

      Version of Record online: 17 APR 2016 | DOI: 10.1111/bjd.14412

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      What's already known about this topic?

      • Calcinosis cutis is a chronic calcium-mediated disease that causes significant morbidity for patients.
      • Multiple treatments have been tried, many of them with varying results and side-effects. To date, no standard treatment has been generally accepted.

      What does this study add?

      • Topical sodium metabisulfite is a new, inexpensive emerging therapy that should be considered as a valid alternative treatment in patients with calcinosis cutis, especially in countries where topical sodium thiosulfate is not available.
    2. Two cases of overlap severe cutaneous adverse reactions to benznidazole treatment for asymptomatic Chagas disease in a nonendemic country

      J. González-Ramos, L. Noguera-Morel, H.Y. Tong, E. Ramírez, E. Ruiz-Bravo, T. Bellón, R. Cabañas, L. Cachafeiro and P. Herranz-Pinto

      Version of Record online: 7 APR 2016 | DOI: 10.1111/bjd.14451

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      What's already known about this topic?

      • Cutaneous reactions to benznidazole are common; however, severe cases have rarely been reported.

      What does this study add?

      • Benznidazole may induce potentially life-threatening severe cutaneous adverse reactions.
      • There should be greater awareness among physicians of this newly reported risk.
  85. Medical Dermatology

    1. Calculation of cut-off values based on the Autoimmune Bullous Skin Disorder Intensity Score (ABSIS) and Pemphigus Disease Area Index (PDAI) pemphigus scoring systems for defining moderate, significant and extensive types of pemphigus

      C. Boulard, S. Duvert Lehembre, C. Picard-Dahan, J.S. Kern, G. Zambruno, C. Feliciani, B. Marinovic, P. Vabres, L. Borradori, C. Prost-Squarcioni, B. Labeille, M.A. Richard, S. Ingen-Housz-Oro, E. Houivet, V.P. Werth, D.F. Murrell, M. Hertl, J. Benichou, P. Joly and on behalf of the International Pemphigus Study Group

      Version of Record online: 3 APR 2016 | DOI: 10.1111/bjd.14405

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      What's already known about this topic?

      • The Autoimmune Bullous Skin Disorder Intensity Score (ABSIS) and Pemphigus Disease Area Index (PDAI) are new scoring systems to measure pemphigus activity.
      • The use of these scores in clinical practice is limited by the absence of cut-off values.

      What does this study add?

      • Cut-off values distinguishing moderate, significant and extensive pemphigus were 15 and 45 for PDAI, and 17 and 53 for ABSIS.
      • These disease activity subgroups should help physicians in the management of patients with pemphigus.
  86. Research Letters

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