British Journal of Dermatology

Cover image for Vol. 172 Issue 3

Early View (Online Version of Record published before inclusion in an issue)

Editor: Alex Anstey, Newport, UK

Impact Factor: 4.1

ISI Journal Citation Reports © Ranking: 2013: 7/61 (Dermatology)

Online ISSN: 1365-2133

Associated Title(s): Clinical and Experimental Dermatology

VIEW

  1. 1 - 88
  1. Therapeutics

    1. You have full text access to this OnlineOpen article
      Long-term efficacy and safety of ustekinumab, with and without dosing adjustment, in patients with moderate-to-severe psoriasis: results from the PHOENIX 2 study through 5 years of follow-up

      R.G. Langley, M. Lebwohl, G.G. Krueger, P.O. Szapary, Y. Wasfi, D. Chan, M.C. Hsu, Y. You, Y. Poulin, N. Korman, J.C. Prinz, K. Reich and on behalf of the PHOENIX 2 Investigators

      Article first published online: 22 MAR 2015 | DOI: 10.1111/bjd.13469

      What's already known about this topic?

      • Data regarding dosing adjustment from PHOENIX 1 are limited. Protocol-defined dose-interval adjustment was permitted only early in the study based on clinical response.

      What does this study add?

      • PHOENIX 2 evaluated both protocol-defined and investigator-initiated dose and/or dose-interval adjustment.
      • Improved response was generally demonstrated following dosing adjustments; further investigations are required to quantify the actual incremental benefits.
      • Some patients may desire treatment goals beyond 75% improvement in Psoriasis Area and Severity Index.
  2. Epidemiology and Health Services Research

    1. Psoriasis and obesity in French children: a case–control, multicentre study

      E. Mahé, A. Beauchet, C. Bodemer, A. Phan, A.-C. Bursztejn, F. Boralevi, A.-L. Souillet, C. Chiaverini, E. Bourrat, J. Miquel, P. Vabres, S. Barbarot, D. Bessis, C. Eschard, S. Hadj-Rabia and for the Groupe de Recherche de la Société Française de Dermatologie Pédiatrique

      Article first published online: 22 MAR 2015 | DOI: 10.1111/bjd.13507

      What's already known about this topic?

      • The frequency and severity of psoriasis are associated with a high prevalence of obesity in adults.
      • Obesity is associated with severe plaque psoriasis in children.

      What does this study add?

      • Childhood psoriasis is associated with overweight with abdominal obesity, or obesity per se irrespective of the type of psoriasis and its severity.
      • There is no difference in the determinants for obesity in children with psoriasis and controls.
      • The main determinants for overweight in children with psoriasis are female sex and having a parent who is overweight.
  3. Cutaneous Biology

    1. Differential expression and functionality of ATP-binding cassette transporters in the human hair follicle

      I.S. Haslam, C. El-Chami, H. Faruqi, A. Shahmalak, C.A. O'Neill and R. Paus

      Article first published online: 19 MAR 2015 | DOI: 10.1111/bjd.13549

      What's already known about this topic?

      • ATP-binding cassette (ABC) transporters are expressed in the epidermis and cutaneous immune cells (Langerhans cells).
      • ABCB1 and ABCG2 may enhance the transepidermal movement of substrate drugs.
      • ABCC1 is present in the hair follicle.

      What does this study add?

      • A detailed expression and localization map for numerous well-characterized xenobiotic and lipid-transporting ABC proteins in the human hair follicle.
      • The first functional data indicating that ABCB1 and ABCG2 actively reduce the accumulation of substrates within the hair follicle.
  4. Systematic Reviews

    1. The value of in vivo reflectance confocal microscopy in the diagnosis and monitoring of inflammatory and infectious skin diseases: a systematic review

      L. Hoogedoorn, M. Peppelman, P.C.M. van de Kerkhof, P.E.J. van Erp and M.J.P. Gerritsen

      Article first published online: 19 MAR 2015 | DOI: 10.1111/bjd.13499

      What's already known about this topic?

      • Many inflammatory and infectious skin diseases have been imaged by in vivo reflectance confocal microscopy (RCM).

      What does this study add?

      • This systematic review provides an overview and accuracy assessment of RCM features and diagnoses.
      • This review facilitates further implementation of RCM in dermatological practice.
  5. Case Reports

    1. Epidermal barrier abnormalities in exfoliative ichthyosis with a novel homozygous loss-of-function mutation in CSTA

      V. Moosbrugger-Martinz, A. Jalili, A.S. Schossig, K. Jahn-Bassler, J. Zschocke, M. Schmuth, G. Stingl, K.M. Eckl, H.C. Hennies and R. Gruber

      Article first published online: 18 MAR 2015 | DOI: 10.1111/bjd.13545

      What's already known about this topic?

      • Recently, loss-of-function mutations in CSTA, encoding cysteine protease inhibitor A, were reported to cause autosomal recessive exfoliative ichthyosis (AREI).

      • There is evidence for a key role of cysteine protease inhibitor A in desmosome-mediated cell–cell adhesion within the basal and spinous layers of the human epidermis.

      What does this study add?

      • We report a novel homozygous loss-of-function mutation in CSTA.
      • Transmission electron microscopy revealed epidermal barrier abnormalities in AREI.
      • We compare the morphological characteristics between AREI and Netherton syndrome (also caused by a protease inhibitor deficiency).
  6. Correspondence

    1. Arthritis possibly induced and exacerbated by a tumour necrosis factor antagonist in a patient with psoriasis vulgaris

      T. Takahashi, Y. Asano, S. Shibata, K. Nakamura, M. Nakao, R. Shida, A. Mitsui, M. Araki, R. Watanabe, H. Fujita, Y. Tada and S. Sato

      Article first published online: 18 MAR 2015 | DOI: 10.1111/bjd.13587

  7. Research Letters

    1. The global burden of disease associated with alopecia areata

      C. Karimkhani, L.N. Boyers, M. Naghavi, L.E. Coffeng, J.P. Lott, S. Wulf, R. Hay, H.C. Williams, M.A. Weinstock, S.A. Norton, A.W. Armstrong, C.A. Dunnick, D.A. Norris and R.P. Dellavalle

      Article first published online: 18 MAR 2015 | DOI: 10.1111/bjd.13559

  8. Review Articles

    1. Phototherapy, photodynamic therapy and photophoresis in the treatment of connective-tissue diseases: a review

      E.A. Gordon Spratt, L.V. Gorcey, N.A. Soter and J.A. Brauer

      Article first published online: 18 MAR 2015 | DOI: 10.1111/bjd.13544

      What's already known about this topic?

      • Connective-tissue diseases, including lupus erythematosus, morphoea/scleroderma and dermatomyositis, occur in patients who are medically complex and have unique cutaneous manifestations that may be recalcitrant to conventional therapies.
      • Given the association of connective-tissue diseases and photosensitivity, the use of light-based therapeutic modalities for these conditions is controversial.

      What does this study add?

      • This review is the first report to examine the evidence available in the literature for the treatment of lupus, morphoea, scleroderma and dermatomyositis with phototherapy, photodynamic therapy and photopheresis.
      • Cutaneous manifestations of some of these connective-tissue disorders may be effectively and safely treated with light-based modalities despite associations with photosensitivity.
  9. Research Letters

    1. New immune system genetic polymorphisms associated with moderate-to-severe plaque psoriasis: a case–control study

      R. Prieto-Pérez, G. Solano-López, T. Cabaleiro, M. Román, D. Ochoa, M. Talegón, O. Baniandrés, J.L.L. Estebaranz, P. de la Cueva, E. Daudén and F. Abad-Santos

      Article first published online: 18 MAR 2015 | DOI: 10.1111/bjd.13585

  10. Therapeutics

    1. Latent tuberculosis infection in patients with chronic plaque psoriasis: evidence from the Italian Psocare Registry

      P. Gisondi, S. Cazzaniga, S. Chimenti, M. Maccarone, M. Picardo, G. Girolomoni, L. Naldi and the Psocare Study Group

      Article first published online: 17 MAR 2015 | DOI: 10.1111/bjd.13539

      What's already known about this topic?

      • Screening for latent tuberculosis infection (LTBI) is mandatory in patients with psoriasis candidate to biological therapy.
      • The risk of developing active tuberculosis in patients treated with tumour necrosis factor-α inhibitors is significantly higher than in subjects not exposed to biologics.

      What does this study add?

      • The nationwide prevalence of LTBI in patients with psoriasis enrolled in the Psocare registry is 8·3%.
      • Independent factors associated with LTBI were male sex, age over 55 years and being entered into a conventional treatment.
  11. Photodermatology

    1. Efficacy of ablative fractional laser-assisted photodynamic therapy for the treatment of actinic cheilitis: 12-month follow-up results of a prospective, randomized, comparative trial

      S.H. Choi, K.H. Kim and K.-H. Song

      Article first published online: 15 MAR 2015 | DOI: 10.1111/bjd.13542

      What's already known about this topic?

      • Photodynamic therapy (PDT) is less efficient for actinic cheilitis (AC) than for actinic keratosis.
      • Use of an erbium:yttrium–aluminium–garnet ablative fractional laser (Er:YAG AFL) improves the methyl aminolaevulinate (MAL) penetration into deeper portions of lesions.

      What does this study add?

      • The present study showed Er:YAG AFL-assisted MAL-PDT is better for the treatment of AC and requires fewer sessions than conventional MAL-PDT.
  12. Scholarly Reviews

    1. Approach to chronic wound infections

      D. Leaper, O. Assadian and C.E. Edmiston

      Article first published online: 15 MAR 2015 | DOI: 10.1111/bjd.13677

      What's already known about this topic?

      • Infection is the most likely cause of stalled healing in chronic wounds.
      • Infection in chronic wounds is a clinical decision-making process; a diagnostic would be useful for practitioners.
      • Presence of biofilm cannot be detected clinically and a diagnostic is needed.

      What does this study add?

      • Presence of biofilm is the likely cause of persistent infection and requires maintenance debridement at dressing changes, as well as topical antiseptic intervention.
      • Use of antibiotics to treat infections in chronic wounds requires strict antibiotic stewardship.
  13. Correspondence

    1. Successful switch to dabrafenib after vemurafenib-induced toxic epidermal necrolysis

      G. Jeudy, S. Dalac-Rat, B. Bonniaud, A. Hervieu, T. Petrella, E. Collet and P. Vabres

      Article first published online: 15 MAR 2015 | DOI: 10.1111/bjd.13522

    2. Acute generalized exanthematous pustulosis: a retrospective audit of practice between 1994 and 2011 at a single centre

      S. Ingen-Housz-Oro, C. Hotz, L. Valeyrie-Allanore, E. Sbidian, F. Hemery, O. Chosidow and P. Wolkenstein

      Article first published online: 15 MAR 2015 | DOI: 10.1111/bjd.13540

  14. Case Reports

    1. Chromium-induced diffuse dermatitis with lymph node involvement resulting from Langerhans cell histiocytosis after metal-on-metal hip resurfacing

      N. Bizzotto, A. Sandri, G. Trivellin, B. Magnan, G.M. Micheloni, A. Zamò, P. Bernardi, A. Sbarbati and D. Regis

      Article first published online: 15 MAR 2015 | DOI: 10.1111/bjd.13517

      What's already known about this topic?

      • Metal-on-metal (MOM) hip resurfacing (HR) is frequently associated with metallic corrosion, the release of wear debris and high levels of metal ions in the blood.
      • Systemic and local signs of prolonged exposure to metal ions include hypersensitivity, possible carcinogenicity and pseudotumour formation.
      • Metal-related dermatitis and lymphadenopathy after orthopaedic joint prostheses are well known.

      What does this study add?

      • Combined diffuse dermatitis with lymph node involvement resulting from Langerhans cell histiocytosis induced by chromium after MOM-HR has not been previously reported.
      • Prolonged release of metal ions and high serum levels may cause sensitization and type IV hypersensitivity reaction to chromium. Lymphadenopathy with diagnosis of special Langerhans cell histiocytosis may be due to prolonged activation of the type IV immune response.
      • Replacing the prosthesis using alternative coupling surfaces is the only approach that can resolve these symptoms.
  15. Correspondence

    1. Comparison of reflectance confocal microscopy and standardized skin surface biopsy for three different lesions in a pityriasis folliculorum patient

      C. Yuan, X.-M. Wang, A. Guichard, T. Lihoreau, S. Mac-Mary, L. Khyat, M. Ardigò and P. Humbert

      Article first published online: 15 MAR 2015 | DOI: 10.1111/bjd.13506

  16. Research Letters

  17. Correspondence

    1. Mutations in GJB6 causing phenotype resembling pachyonychia congenita

      G.I. Hale, N.J. Wilson, F.J.D. Smith, G. Wylie, M.E. Schwartz and M. Zamiri

      Article first published online: 13 MAR 2015 | DOI: 10.1111/bjd.13520

  18. Research Letters

  19. Correspondence

    1. Myopathy in hereditary leiomyomatosis and renal cell cancer in an extended family

      A. España, E. Ornilla, R. Zarate, I. Gil-Bazo and P. Briones

      Article first published online: 11 MAR 2015 | DOI: 10.1111/bjd.13504

    2. You have full text access to this OnlineOpen article
      Statin therapy for venous ulcers

      J.E. Dickerson and H.B. Slade

      Article first published online: 11 MAR 2015 | DOI: 10.1111/bjd.13349

    3. Two novel mutations in the LOR gene in three families with loricrin keratoderma

      A. Hotz, E. Bourrat, I. Hausser, M. Haftek, M.V. da Silva and J. Fischer

      Article first published online: 9 MAR 2015 | DOI: 10.1111/bjd.13414

  20. Dermatological Surgery and Lasers

    1. Mohs micrographic surgery in dermatofibrosarcoma protuberans allows tumour clearance with smaller margins and greater preservation of healthy tissue compared with conventional surgery: a study of 74 primary cases

      C. Serra-Guillén, B. Llombart, E. Nagore, C. Guillén, C. Requena, V. Traves, S. Kindem, R. Alcalá, N. Rivas and O. Sanmartín

      Article first published online: 9 MAR 2015 | DOI: 10.1111/bjd.13417

      What's already known about this topic?

      • Dermatofibrosarcoma protuberans (DFSP) is a malignant tumour with unpredictable subclinical extension in the form of asymmetric tentacle-like projections.
      • Conventional surgical excision with wide margins usually removes a large amount of healthy skin and does not always completely remove the tumour.
      • Mohs micrographic surgery (MMS) achieves tumour clearance with smaller margins than conventional surgery, but the amount of tissue spared has never been quantified.

      What does this study add?

      • It is impossible to recommend an optimal margin for the conventional excision of DFSP, as each tumour has a unique subclinical extension.
      • MMS should be the treatment of choice in DFSP because it is associated with high cure rates and avoids unnecessarily large surgical defects.
      • The mean percentages of skin spared using MMS rather than conventional surgery with 2- and 3-cm margins are 49·4% and 67·9%, respectively.
  21. Epidemiology and Health Services Research

    1. Relations between the characteristics and psychological comorbidities of chronic pruritus differ between men and women: women are more anxious than men

      A. Stumpf, S. Ständer, B. Warlich, F. Fritz, P. Bruland, B. Pfleiderer, G. Heuft and G. Schneider

      Article first published online: 9 MAR 2015 | DOI: 10.1111/bjd.13492

      What's already known about this topic?

      • Chronic pruritus (CP) is a symptom with a negative impact on quality of life and is known to be associated with anxiety and depression.
      • To our knowledge, no study has investigated sex-specific differences in this context.

      What does this study add?

      • We found sex-specific differences in anxiety levels and distinct pruritus characteristics and clinical features in relation to anxiety and depression. We believe that these findings are of importance to clinicians and basic researchers.
  22. Dermatological Surgery and Lasers

    1. The clinical and dermoscopic features of invasive cutaneous squamous cell carcinoma depend on the histopathological grade of differentiation

      A. Lallas, J. Pyne, A. Kyrgidis, S. Andreani, G. Argenziano, A. Cavaller, J. Giacomel, C. Longo, A. Malvestiti, E. Moscarella, S. Piana, F. Specchio, R. Hofmann-Wellenhof and I. Zalaudek

      Article first published online: 9 MAR 2015 | DOI: 10.1111/bjd.13510

      What's already known about this topic?

      • While the dermoscopic criteria of squamous cell carcinoma (SCC) have been well described, little is currently known about the variability of these criteria with respect to the histopathological grade of differentiation in SCC.

      What does this study add?

      • Poorly differentiated SCC is dermoscopically typified by a predominantly red colour, attributed to the presence of bleeding and/or dense vascularity.
      • Identifying poorly differentiated tumours in vivo may enhance their appropriate management.
  23. Cutaneous Biology

    1. Phenotypic modulation of smooth muscle cells in lymphoedema

      F. Ogata, K. Fujiu, I. Koshima, R. Nagai and I. Manabe

      Article first published online: 9 MAR 2015 | DOI: 10.1111/bjd.13482

      What's already known about this topic?

      • Lymphoedema is a debilitating progressive condition that is frequently observed following cancer surgery and severely restricts quality of life.
      • Although it is known that lymphatic dysfunction and obstruction underlie lymphoedema, the pathogenic mechanism is poorly understood.

      What does this study add?

      • Lymphatic smooth muscle cells play a key role in the development of lymphoedema.
  24. Research Letters

    1. Livedo-like dermatitis and necrotic lesions after high-dose buprenorphine injections: a national French survey

      L. Wainstein, C. Bernier, M. Gérardin, R. Bouquié, O. Espitia, J.M. Mussini, P. Jolliet and C. Victorri-Vigneau

      Article first published online: 9 MAR 2015 | DOI: 10.1111/bjd.13503

  25. Correspondence

  26. Case Reports

    1. Whole-exome sequencing diagnosis of two autosomal recessive disorders in one family

      T. Takeichi, A. Nanda, S. Aristodemou, J.R. McMillan, J. Lee, M. Akiyama, H. Al-Ajmi, M.A. Simpson and J.A. McGrath

      Article first published online: 7 MAR 2015 | DOI: 10.1111/bjd.13473

      What's already known about this topic?

      • Mutations in the suppression of tumorigenicity 14 gene (ST14), encoding matriptase, underlie autosomal recessive congenital ichthyosis type 11 (ARCI11). To date, only four pathogenic mutations in ST14 have been reported.
      • Walker–Warburg syndrome (WWS) is a rare autosomal recessive disorder with developmental malformations, resulting from mutations in POMT1, which encodes O-mannosyltransferase.
      • Next-generation sequencing has the potential to reveal both anticipated and incidental mutations.

      What does this study add?

      • Using whole-exome sequencing, we identified a new homozygous splice-site mutation in ST14 in a 4-year-old Bedouin girl with ARCI11.
      • Bioinformatics analysis of the exome dataset revealed that this girl was also heterozygous for a mutation in POMT1, providing insight into WWS affecting two other siblings in this family.
      • Whole-exome sequencing can provide both molecular diagnostics for known disorders, and data that can improve clinical diagnosis and genetic counselling.
  27. Correspondence

    1. Distinctive clinical and dermoscopic features of BRAF V600K mutated melanomas

      G. Ponti, M. Manfredini, A. Tomasi and G. Pellacani

      Article first published online: 7 MAR 2015 | DOI: 10.1111/bjd.13484

  28. Therapeutics

    1. You have full text access to this OnlineOpen article
      Long-term safety and efficacy of bimatoprost solution 0·03% application to the eyelid margin for the treatment of idiopathic and chemotherapy-induced eyelash hypotrichosis: a randomized controlled trial

      D.A. Glaser, P. Hossain, W. Perkins, T. Griffiths, G. Ahluwalia, E. Weng and F.C. Beddingfield

      Article first published online: 7 MAR 2015 | DOI: 10.1111/bjd.13443

      What's already known about this topic?

      • The safety and efficacy of bimatoprost ophthalmic solution 0·03% have been previously established for idiopathic hypotrichosis in studies lasting up to 4 months.

      What does this study add?

      • Very little has been reported on eyelash loss and regrowth after chemotherapy, and there is currently no standard prevention or treatment for chemotherapy-induced hypotrichosis of the eyelashes.
      • We provide long-term (up to 12 months) safety and efficacy data for treatment with bimatoprost ophthalmic solution 0·03% in chemotherapy-induced and idiopathic hypotrichosis.
  29. Research Letters

    1. BRAF, NRAS and MC1R status in a prospective series of primary cutaneous melanoma

      Z. García-Casado, V. Traves, J. Bañuls, M. Niveiro, E. Gimeno-Carpio, A.I. Jimenez-Sanchez, M. Moragón, J.A. Onrubia, V. Oliver, R. Kumar and E. Nagore

      Article first published online: 6 MAR 2015 | DOI: 10.1111/bjd.13521

  30. Clinical and Laboratory Investigations

    1. Prevalence of myasthenia gravis and associated autoantibodies in paraneoplastic pemphigus and their correlations with symptoms and prognosis

      R. Wang, J. Li, M. Wang, H. Hao, X. Chen, R. Li and X. Zhu

      Article first published online: 5 MAR 2015 | DOI: 10.1111/bjd.13525

      What's already known about this topic?

      • Paraneoplastic pemphigus is a life-threatening multiorgan autoimmune syndrome.
      • Myasthenia gravis is an autoimmune neurological disorder occasionally associated with various autoimmune diseases.

      What does this study add?

      • This is the first detailed demonstration of a clear association between myasthenia gravis and paraneoplastic pemphigus.
      • Antiacetylcholine receptor and antiacetylcholinesterase antibodies are prominent in patients with paraneoplastic pemphigus, especially those with dyspnoea.
  31. Research Letters

    1. Blaschko line acne on pre-existent hypomelanosis reflecting a mosaic FGFR2 mutation

      D. Kiritsi, A.I. Lorente, R. Happle, J. Bernabeu Wittel and C. Has

      Article first published online: 5 MAR 2015 | DOI: 10.1111/bjd.13491

  32. Clinical and Laboratory Investigations

    1. Morphological features of naevoid melanoma: results of a multicentre study of the International Dermoscopy Society

      C. Longo, S. Piana, A. Marghoob, S. Cavicchini, P. Rubegni, C. Cota, G. Ferrara, A.M. Cesinaro, A. Baade, P.L. Bencini, F. Mantoux, Z.P. Mijuskovic, M.A. Pizzichetta, I. Stanganelli, C. Carrera, G.L. Giovene, S. Ranasinghe, I. Zalaudek, A. Lallas, E. Moscarella, F. Specchio, P. Pepe, G. Pellacani and G. Argenziano

      Article first published online: 5 MAR 2015 | DOI: 10.1111/bjd.13524

      What's already known about this topic?

      • Naevoid melanoma is a rare variant of melanoma, and can be difficult to detect as its clinical and histopathological morphology can simulate a naevus.

      What does this study add?

      • This study provides new insights into the clinical and dermoscopic morphology of naevoid melanoma, facilitating its clinical recognition.
  33. Systematic Reviews

    1. Socioeconomic and lifestyle factors and melanoma: a systematic review

      A.J. Jiang, P.V. Rambhatla and M.J. Eide

      Article first published online: 4 MAR 2015 | DOI: 10.1111/bjd.13500

      What's already known about this topic?

      • Higher socioeconomic status (SES) populations have increased incidence and decreased mortality of melanoma.
      • Lifestyle factors such as occupational exposure, recreational ultraviolet radiation exposure and tanning increase melanoma incidence, and may be related to SES.

      What does this study add?

      • With this systematic review, we found lifestyle factors including occupation, occupational exposure, obesity, recreational sun exposure and tanning may explain the association between SES and melanoma.
  34. Epidemiology and Health Services Research

    1. A pilot trial of mobile, patient-performed teledermoscopy

      M.N. Manahan, H.P. Soyer, L.J. Loescher, C. Horsham, D. Vagenas, D.C. Whiteman, C.M. Olsen and M. Janda

      Article first published online: 4 MAR 2015 | DOI: 10.1111/bjd.13550

      What's already known about this topic?

      • Cancer agencies recommend skin self-examination (SSE).
      • Teledermoscopy (if done during clinic visits) has excellent concordance with face-to-face clinical examination, but the sensitivity and specificity of SSE plus mobile teledermoscopy done by people at home has not been studied.

      What does this study add?

      • The sensitivity of SSE plus teledermoscopy ranges from 42% to 82%, and the specificity from 56·3% to 89·6% depending on the analytical method.
      • SSE could complement melanoma screening and/or surveillance efforts.
  35. Dermatological Surgery and Lasers

    1. Intraoperative diagnosis of nonpigmented nail tumours with ex vivo fluorescence confocal microscopy: 10 cases

      S. Debarbieux, R. Gaspar, L. Depaepe, S. Dalle, B. Balme and L. Thomas

      Article first published online: 4 MAR 2015 | DOI: 10.1111/bjd.13384

      What's already known about this topic?

      • Ex vivo fluorescence confocal microscopy (FCM) enables real-time imaging of freshly excised tissue.

      What does this study add?

      • We describe for the first time ex vivo FCM features of various histological subtypes of nonpigmented tumours of the nail unit.
      • Intraoperative diagnosis of malignant tumours of the nail apparatus may shorten their surgical management.
  36. Meeting Reports

  37. Dermatological Surgery and Lasers

    1. Sentinel lymph node biopsy and risk factors for predicting metastasis in cutaneous squamous cell carcinoma

      J.T. Krediet, M. Beyer, K. Lenz, C. Ulrich, B. Lange-Asschenfeldt, E. Stockfleth and D. Terhorst

      Article first published online: 4 MAR 2015 | DOI: 10.1111/bjd.13508

      What's already known about this topic?

      • Cutaneous squamous cell carcinoma (cSCC) is a common cancer capable of metastasis.
      • Different risk factors such as tumour thickness and tumour diameter have been discussed for determining the risk of metastasis.
      • Sentinel lymph node biopsy (SLNB) may be a valuable adjunct for patients with cSCC at high risk for metastases; however, it is currently described only in case reports and small case series with limited follow-up.

      What does this study add?

      • The risk for metastases from a cSCC is associated with tumour thickness > 4 mm and tumour recurrence.
      • All metastases occurred within 2 years after excision. SLNB seems to have a low sensitivity for metastases of cSCC.
      • Despite a negative SLNB, some patients developed metastatic disease, underlining the necessity of close follow-up of high-risk patients in the first 2 years after excision, regardless of SLNB status.
  38. Epidemiology and Health Services Research

    1. Association between psoriasis and asthma: a population-based retrospective cohort analysis

      H.-Y. Fang, W.-C. Liao, C.-L. Lin, C.-H. Chen and C.-H. Kao

      Article first published online: 4 MAR 2015 | DOI: 10.1111/bjd.13518

      What's already known about this topic?

      • Both psoriasis and asthma are chronic immune-mediated inflammatory diseases.
      • Studies have shown that psoriasis is associated with systemic comorbidities.
      • Recent studies have defined psoriasis as a systemic chronic inflammatory disease.

      What does this study add?

      • After adjusting for age, sex and comorbidities, the risk of asthma was 1·38-fold higher in the cohort with psoriasis than in the reference cohort.
      • The incidence of asthma in male and female patients with psoriasis exhibited nonsignificant differences.
      • Among all patients aged > 50 years, patients with psoriasis were more likely to have higher risk of asthma compared with those without psoriasis.
  39. Clinical and Laboratory Investigations

    1. Alteration in regulatory T cells and programmed cell death 1-expressing regulatory T cells in active generalized vitiligo and their clinical correlation

      M.K. Tembhre, A.S. Parihar, V.K. Sharma, A. Sharma, P. Chattopadhyay and S. Gupta

      Article first published online: 27 FEB 2015 | DOI: 10.1111/bjd.13511

      What's already known about this topic?

      • Generalized vitiligo (GV) is an autoimmune depigmentation disease.
      • Deregulation in immune regulatory components has been proposed in its pathogenesis.

      What does this study add?

      • Deficiency in regulatory T cells (Tregs), altered expression of Treg-associated parameters and increased percentage of programmed cell death 1-positive Tregs in active GV were the main findings of the study.
      • Clinical correlation was also established. Major defects in immune regulatory components were identified during the first episode of disease attack.
  40. Review Articles

    1. The genetics of pyoderma gangrenosum and implications for treatment: a systematic review

      E.M. DeFilippis, S.R. Feldman and W.W. Huang

      Article first published online: 27 FEB 2015 | DOI: 10.1111/bjd.13493

      What's already known about this topic?

      • Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis characterized by painful skin ulcerations for which treatment can be challenging.

      What does this study add?

      • This study reviews over 823 cases of PG and its associated gene mutations and syndromes.
      • The various treatments of PG, depending on the underlying disease association, are discussed.
  41. Paediatric Dermatology

    1. Human herpesvirus 6 involvement in paediatric drug hypersensitivity syndrome

      J. Ahluwalia, K. Abuabara, M.J. Perman and A.C. Yan

      Article first published online: 27 FEB 2015 | DOI: 10.1111/bjd.13512

      What's already known about this topic?

      • Human herpesvirus (HHV)6 has been associated with a more severe form of drug hypersensitivity syndrome (DHS) in the general adult population.
      • Administration of systemic corticosteroids is the mainstay treatment of DHS.

      What does this study add?

      • This study investigated a retrospective series to evaluate the factor of HHV6 positivity on DHS progression in paediatric patients.
      • Systemic corticosteroid treatment was associated with a trend towards a shorter hospital stay and fewer febrile days.
      • Systemic corticosteroids significantly reduced the number of days until cessation of progression in patients with DHS.
  42. Dermatological Surgery and Lasers

    1. Novel methods for generating fractional epidermal micrografts

      M. Purschke, F.A. Asrani, S.A. Sabir, W.A. Farinelli and R.R. Anderson

      Article first published online: 27 FEB 2015 | DOI: 10.1111/bjd.13468

      What's already known about this topic?

      • Current treatments for vitiligo and chronic wounds are often not very effective and unsatisfying for patients.
      • Conventional epidermal blister grafting is one treatment option for chronic vitiligo, but is time consuming, limited to small areas and requires surgical skill.

      What does this study add?

      • Novel fractional epidermal micrografting is a promising alternative treatment for vitiligo and chronic wounds with fewer side-effects to donor and receptor sites and has the advantage of treating larger lesions.
  43. Clinical and Laboratory Investigations

    1. Thymic stromal lymphopoietin induction by skin irritation is independent of tumour necrosis factor-α, but supported by interleukin-1

      V. Kumari, M. Babina, T. Hazzan and M. Worm

      Article first published online: 27 FEB 2015 | DOI: 10.1111/bjd.13465

      What's already known about this topic?

      • Thymic stromal lymphopoietin (TSLP) is closely associated with allergic diseases of the skin and respiratory tract, where it is mainly produced by epithelial and some mesenchymal cells.
      • TSLP skews T helper type 2 immune responses by targeting multiple immune cells, including dendritic cells.
      • Further up in the hierarchical system, several mediators regulate TSLP expression. Tumour necrosis factor (TNF)-α occupies a prominent position among these mediators when applied exogenously; however, the in vivo relevance of TNF-α is barely defined.

      What does this study add?

      • TSLP is rapidly induced upon physicochemical irritation in murine skin in vivo and enters the circulatory system.
      • Endogenous TNF-α is not involved in skin TSLP production under a multitude of conditions in murine skin, and this seems to apply to an even greater extent in human skin.
      • Interleukin-1 partially mediates this irritation-induced TSLP expression. This effect is more prominent in human skin, which displays significant differences in TSLP regulation compared with murine skin.
  44. Epidemiology and Health Services Research

    1. Occlusive gloves and skin conditions: is there a problem? Results of a cross-sectional study in a semiconductor company

      W. Weistenhöfer, M. Wacker, F. Bernet, W. Uter and H. Drexler

      Article first published online: 27 FEB 2015 | DOI: 10.1111/bjd.13481

      What's already known about this topic?

      • Prolonged glove occlusion is considered to be a risk factor for developing hand eczema similar to wet work.
      • Scientific evidence that it is as damaging as wet work is hitherto largely lacking.

      What does this study add?

      • This study involved a large sample of clean-room workers not exposed to additional hazardous substances.
      • Prolonged wearing of occlusive gloves during whole working days does not affect the skin negatively.
  45. Case Reports

    1. Progressive hyperpigmentation in a Taiwanese child due to an inborn error of vitamin B12 metabolism (cblJ)

      T. Takeichi, C.-K. Hsu, H.-S. Yang, H.-Y. Chen, T.-W. Wong, W.-L. Tsai, S.-C. Chao, J.Y.-Y. Lee, M. Akiyama, M.A. Simpson and J.A. McGrath

      Article first published online: 27 FEB 2015 | DOI: 10.1111/bjd.13413

      What's already known about this topic?

      • Inherited defects affecting vitamin B12 (cobalamin, cbl) metabolism can result in various haematological and neurological abnormalities, as well as occasional changes in the skin.
      • Nine different metabolic defects in the intracellular processing of cbl have been reported, which led to isolated methylmalonic aciduria and/or isolated homocystinuria.
      • The most recently described disease subtype is cblJ, resulting from mutations in ABCD4; three individuals with ABCD4 mutations have been described.

      What does this study add?

      • We identified a homozygous missense mutation in ABCD4 in a 12-year-old girl with progressive hyperpigmentation.
      • ABCD4 mutations can lead to skin hyperpigmentation in the absence of any neurological abnormalities, thus ABCD4 is a further candidate gene for familial progressive hyperpigmentation.
      • Treatment with oral cbl can reduce the hyperpigmentation that results from ABCD4 mutations over several months.
  46. Photobiology

    1. Genotype–phenotype correlation of xeroderma pigmentosum in a Chinese Han population

      Z. Sun, J. Zhang, Y. Guo, C. Ni, J. Liang, R. Cheng, M. Li and Z. Yao

      Article first published online: 27 FEB 2015 | DOI: 10.1111/bjd.13429

      What's already known about this topic?

      • Xeroderma pigmentosum (XP) is a rare autosomal recessive disorder characterized by extreme sensitivity to sunlight, freckle-like pigmentation and a greatly increased incidence of skin cancers.
      • XP has been found in all continents, in all races. However, genetic mutation detection and genotype–phenotype analyses of XP are rarely reported in the Chinese Han population.

      What does this study add?

      • We identified 13 novel mutations and extended the spectrum of genetic mutation in a Chinese Han population.
      • In our cohort of patients with XP-C (XPC), XP-G (ERCC5), XP-A (XPA) and XP-V (POLH), patients with XP-G have no neurological symptoms, those with XP-A and XP-V have a high incidence of malignancy.
      • Lack of stringent protection against exposure to sunlight, late diagnosis and long duration of disease play an important role in XP in the Chinese Han population.
  47. Case Reports

    1. Dacryocystitis due to Sporothrix brasiliensis: a case report of a successful clinical and serological outcome with low-dose potassium iodide treatment and oculoplastic surgery

      P. Marques de Macedo, D.C.N. Sztajnbok, Z.P. Camargo, A.M. Rodrigues, L.M. Lopes-Bezerra, A.R. Bernardes-Engemann and R. Orofino-Costa

      Article first published online: 27 FEB 2015 | DOI: 10.1111/bjd.13378

      What's already known about this topic?

      • Sporotrichosis is a worldwide granulomatous disease caused by several Sporothrix spp., commonly acquired by local trauma with contaminated organic material or via contact with diseased animals, especially cats.
      • Usual clinical forms are cutaneous/lymphocutaneous and first-line treatment is oral itraconazole.

      What does this study add?

      • Special forms of sporotrichosis have been described mainly in zoonotic epidemics ongoing in South and Southeast Brazil and it could be related to differences in frequencies among Sporothrix spp. as well as types of transmissions involving sapronosis or zoonosis.
      • Therefore, molecular identification may be helpful to guide treatment and for epidemiological purposes. In addition, serology may support clinical decisions.
      • Combined treatment can avoid functional sequelae.
  48. Correspondence

    1. Disseminated atrophic sarcoidosis with elastophagocytosis and elastic tissue loss

      W. Fancher, M. Braniecki, G. Guzman, J. Groth and A. Krunic

      Article first published online: 27 FEB 2015 | DOI: 10.1111/bjd.13401

  49. Dermatological Surgery and Lasers

    1. A national study on adherence to a basal cell carcinoma guideline; development of a tool to assess guideline adherence

      R.J. Borgonjen, J.J.E. van Everdingen, C.A.F.M. Bruijnzeel-Koomen, P.C.M. van de Kerkhof and Ph.I. Spuls

      Article first published online: 27 FEB 2015 | DOI: 10.1111/bjd.13351

      What's already known about this topic?

      • Implementation of a dermatological clinical practice guideline is a complex process.
      • Not all recommendations in a guideline are adhered to.

      What does this study add?

      • Possible implementation barriers when applying a basal cell carcinoma guideline.
      • A method to receive structured feedback from daily dermatological practice.
  50. Correspondence

    1. Three-dimensional high-definition optical coherence tomography image acquisition procedure for basal cell carcinoma

      M. Boone, M. Suppa, M. Miyamoto, A. Marneffe, G.B.E. Jemec, G. Pellacani and V. Del Marmol

      Article first published online: 26 FEB 2015 | DOI: 10.1111/bjd.13474

  51. Cutaneous Biology

    1. The hand eczema proteome: imbalance of epidermal barrier proteins

      S. Molin, J. Merl, K.A. Dietrich, M. Regauer, M. Flaig, V. Letulé, T. Saucke, T. Herzinger, T. Ruzicka and S.M. Hauck

      Article first published online: 26 FEB 2015 | DOI: 10.1111/bjd.13418

      What's already known about this topic?

      • Chronic hand eczema (CHE) is a common skin disease with a high socioeconomic impact.
      • While some light has been shed on genetic factors that predispose individuals to the disease, little is known about its actual pathogenesis.
      • Several recent findings indicate that CHE develops as a consequence of an impaired epidermal barrier.

      What does this study add?

      • We aimed to carry out a systematic and comprehensive analysis of the differential protein expression in CHE using state-of-the-art mass spectrometry.
      • We performed liquid chromatography with tandem mass spectrometry analyses and label-free quantification to analyse the proteomic profile of palmar skin from patients with hand eczema and healthy volunteers.
      • To our knowledge, this is the first study to employ this approach. The results of our study demonstrate that skin-barrier dysfunction plays an essential role in the pathogenesis of CHE.
  52. Correspondence

    1. Dermoscopy margin delineation in radiotherapy planning for superficial or nodular basal cell carcinoma

      R. Ballester Sánchez, O. Pons Llanas, J. Pérez Calatayud and R. Botella Estrada

      Article first published online: 26 FEB 2015 | DOI: 10.1111/bjd.13402

  53. Cutaneous Allergy

    1. Cross-elicitation responses to 2-methoxymethyl-p-phenylenediamine under hair dye use conditions in p-phenylenediamine-allergic individuals

      B. Blömeke, L.M. Pot, P.-J. Coenraads, J. Hennen, M. Kock and C. Goebel

      Article first published online: 26 FEB 2015 | DOI: 10.1111/bjd.13412

      What's already known about this topic?

      • 2-Methoxymethyl-p-phenylenediamine (ME-PPD) is a new p-phenylenediamine (PPD) derivative with reduced skin-sensitization properties.

      What does this study add?

      • Exposure to a hair dye test product containing ME-PPD on the forearm for 30 min indicated a response in nine of 30 (30%) PPD-allergic individuals, while 70% were negative.
      • This response rate is significantly lower than we previously reported for PPD under simulated hair dye use conditions (84%).
  54. Paediatric Dermatology

    1. Henoch–Schönlein purpura and systemic disease in children: retrospective study of clinical findings, histopathology and direct immunofluorescence in 34 paediatric patients

      E.F. Johnson, J.S. Lehman, D.A. Wetter, C.M. Lohse and M.M. Tollefson

      Article first published online: 25 FEB 2015 | DOI: 10.1111/bjd.13472

      What's already known about this topic?

      • Henoch–Schönlein purpura (HSP) is commonly associated with systemic involvement.

      What does this study add?

      • Lesions above the waist and clinically evident oedema are associated with gastrointestinal involvement.
      • Renal involvement is associated with perivascular C3 on direct immunofluorescence and with microscopic dermal oedema.
      • Clinical and microscopic findings may help predict systemic involvement in HSP in children.
  55. Review Articles

    1. Pseudofolliculitis cutis: a vexing disorder of hair growth

      T.J. Jasterzbski and R.A. Schwartz

      Article first published online: 25 FEB 2015 | DOI: 10.1111/bjd.13427

      What's already known about this topic?

      • Pseudofolliculitis cutis (PFC) is a chronic inflammatory condition triggered by ingrown hair, commonly found in the beard region of men of sub-Saharan African lineage.

      What does this study add?

      • A combination of curly hair and a keratin 75 polymorphism may increase the risk for developing PFC.
      • An evaluation of PFC treatment is provided to enhance efficacy, safety and adherence.
  56. Cutaneous Biology

    1. Altered manifestations of skin disease at sites affected by neurological deficit

      E. Azimi, E.A. Lerner and S.B. Elmariah

      Article first published online: 25 FEB 2015 | DOI: 10.1111/bjd.13352

      What's already known about this topic?

      • The manifestation of inflammatory skin disease is altered and typically diminished following nerve damage.

      What does this study add?

      • We suggest that sensory neurons are necessary contributors to inflammatory skin disease and that neural blockade may serve as a primary or adjunctive approach to the treatment of certain inflammatory diseases.
  57. Correspondence

    1. Skipped exon in COL7A1 determines the clinical phenotypes of dystrophic epidermolysis bullosa

      E. Toyonaga, W. Nishie, M. Komine, S. Murata, S. Shinkuma, K. Natsuga, H. Nakamura, M. Ohtsuki and H. Shimizu

      Article first published online: 25 FEB 2015 | DOI: 10.1111/bjd.13386

  58. Photobiology

    1. Cutaneous leishmaniasis responds to daylight-activated photodynamic therapy: proof of concept for a novel self-administered therapeutic modality

      C.D. Enk, A. Nasereddin, R. Alper, M. Dan-Goor, C.L. Jaffe and H.C. Wulf

      Article first published online: 25 FEB 2015 | DOI: 10.1111/bjd.13490

      What's already known about this topic?

      • Photodynamic therapy (PDT) is effective for cutaneous leishmaniasis, but requires special equipment.
      • Daylight-activated PDT abolishes the need for artificial light sources and has proven effective for the treatment of actinic keratoses.

      What does this study add?

      • Daylight-activated PDT is effective against cutaneous leishmaniasis caused by both Leishmania major and Leishmania tropica.
      • Daylight-activated PDT is a self-administered regimen that can be performed without professional assistance.
  59. Research Letters

    1. Outcome of treatment with azathioprine in severe atopic dermatitis: a 5-year retrospective study of adult outpatients

      S.F. Thomsen, T. Karlsmark, K.K.B. Clemmensen, C. Graversgaard, K.S. Ibler, G.B.E. Jemec and T. Agner

      Article first published online: 25 FEB 2015 | DOI: 10.1111/bjd.13495

  60. Correspondence

    1. Treatment of hidradenitis suppurativa with intralesional photodynamic therapy using a laser diode attached to an optical cable: a promising new approach

      L.M. Valladares-Narganes, M.A. Rodríguez-Prieto, M.D. Blanco-Suárez, C. Rodriguez-Lage and I. García-Doval

      Article first published online: 25 FEB 2015 | DOI: 10.1111/bjd.13385

    2. A novel locus for primary focal hyperhidrosis mapped on chromosome 2q31.1

      J. Chen, M. Lin, X. Chen, Z. Cao, Z. Tan, W. Xiong, Y. Tu and J. Yang

      Article first published online: 25 FEB 2015 | DOI: 10.1111/bjd.13383

    3. Response of livedoid vasculopathy to rivaroxaban

      D.S. Winchester, L.A. Drage and M.D.P. Davis

      Article first published online: 25 FEB 2015 | DOI: 10.1111/bjd.13428

  61. Clinical and Laboratory Investigations

    1. Lack of activity of betulin-based Oleogel-S10 in the treatment of actinic keratoses: a randomized, multicentre, placebo-controlled double-blind phase II trial

      A. Pflugfelder, E. Andonov, B. Weide, T. Dirschka, C. Schempp, E. Stockfleth, A. Stratigos, S. Krüger-Krasagakis, J. Bauer, C. Garbe and T.K. Eigentler

      Article first published online: 25 FEB 2015 | DOI: 10.1111/bjd.13342

      What's already known about this topic?

      • Previous single open-label trials have shown activity for Oleogel-S10 in actinic keratoses, with a clearance of > 75% of the lesions in 79% and 86% of patients.

      What does this study add?

      • In this multicentre randomized double-blind trial Oleogel-S10 was highly tolerable but could not demonstrate superiority over placebo treatment.
  62. Correspondence

    1. Two Spanish cases of atypical melanosis of the foot, an early stage of acral lentiginous melanoma in situ

      D. Menis, L. Maroñas-Jiménez, J. Rodríguez-Peralto, R. Martin-Llamas and F. Vanaclocha-Sebastián

      Article first published online: 15 FEB 2015 | DOI: 10.1111/bjd.13485

  63. Epidemiology and Health Services Research

    1. Use of health care services by patients with psoriasis: a population-based study

      L.-T. Kao, K.-H. Wang, H.-C. Lin, H.-C. Li, S. Yang and S.-D. Chung

      Article first published online: 15 FEB 2015 | DOI: 10.1111/bjd.13442

      What's already known about this topic?

      • Although there are reports in the literature on the economic burden of psoriasis, few studies have compared differences in health care services use between patients with psoriasis and those without it.
      • Only one study has previously reported that patients with psoriasis incur greater health care costs than a general group of patients.

      What does this study add?

      • With regard to both dermatology and nondermatology services, patients with psoriasis had significantly more outpatient visits, and greater outpatient and total costs than those without it.
      • The total cost for all health services was about 1·4-fold greater for patients with psoriasis than those without it.
  64. Paediatric Dermatology

    1. You have full text access to this OnlineOpen article
      Genetic factors associated with naevus count and dermoscopic patterns: preliminary results from the Study of Nevi in Children (SONIC)

      I. Orlow, J.M. Satagopan, M. Berwick, H.L. Enriquez, K.A.M. White, K. Cheung, S.W. Dusza, S.A. Oliveria, M.A. Marchetti, A. Scope, A.A. Marghoob and A.C. Halpern

      Article first published online: 15 FEB 2015 | DOI: 10.1111/bjd.13467

      What's already known about this topic?

      • Total-body naevus counts and dysplastic naevi are important risk factors for melanoma.
      • Naevi with distinct dermoscopic patterns differ in size, anatomical and age distribution, and host pigmentation characteristics.

      What does this study add?

      • We have identified associations between genetic variants and the number of naevi in early age.
      • We have identified associations between host genetics and the dermoscopic pattern of naevi, supporting the hypothesis that naevi distinguished by their dermoscopic pattern represent distinct biological subsets.
  65. Epidemiology and Health Services Research

    1. Personal history of gallstones and risk of incident psoriasis and psoriatic arthritis in U.S. women

      L.X. Tong, S. Wu, T. Li, A.A. Qureshi, E.L. Giovannucci and E. Cho

      Article first published online: 15 FEB 2015 | DOI: 10.1111/bjd.13463

      What's already known about this topic?

      • Psoriasis, a debilitating chronic disease, may share some common risk factors, and thus aetiological pathways, with gallstones.
      • To date, the association between gallstones and psoriasis has not been investigated.

      What does this study add?

      • A history of cholecystectomy-confirmed gallstones was associated with a higher relative risk of developing both psoriasis and psoriatic arthritis (PsA).
      • A history of gallstones was associated with increased risk of developing concomitant PsA, especially in patients with a body mass index < 30 kg m−2.
  66. Therapeutics

    1. Superiority of ivermectin 1% cream over metronidazole 0·75% cream in treating inflammatory lesions of rosacea: a randomized, investigator-blinded trial

      A. Taieb, J.P. Ortonne, T. Ruzicka, J. Roszkiewicz, J. Berth-Jones, P. Briantais, J. Jacovella and on behalf of the Ivermectin Phase III study group

      Article first published online: 11 FEB 2015 | DOI: 10.1111/bjd.13408

      What's already known about this topic?

      • Few therapeutic alternatives currently exist in treating papulopustular rosacea (PPR).

      What does this study add?

      • Ivermectin 1% cream (IVM 1%) once daily was significantly superior to metronidazole 0·75% cream (MTZ 0.75%) twice-daily, in reducing inflammatory lesion counts, as early as week 3 and through 4 months of treatment.
      • IVM 1% cream can be considered an effective anti-inflammatory treatment for PPR.
  67. Dermatological Surgery and Lasers

    1. Growth of periocular basal cell carcinomas

      E. Tan, F.P.Y. Lin, L.H.N. Sheck, P.J. Salmon and S.G.J. Ng

      Article first published online: 8 FEB 2015 | DOI: 10.1111/bjd.13470

      What's already known about this topic?

      • Basal cell carcinomas (BCCs) have traditionally been regarded as slow-growing tumours.
      • Few studies have prospectively and methodologically assessed the growth of BCCs.

      What does this study add?

      • BCCs in the periorbital region grow rapidly, at a rate of 11·2 mm2 monthly or 0·76 mm in diameter per month.
      • Most tumours grew in spite of an incisional or shave biopsy performed at the first appointment.
      • Factors that were related to a faster growth were large initial tumour size, male sex and a recurrent tumour. This growth could result in increased morbidity.
  68. Research letters

    1. Arguments for neuropathic pain in sensitive skin

      C. Saint-Martory, V. Sibaud, J. Theunis, V. Mengeaud, C. Lauzé, A.-M. Schmitt and L. Misery

      Article first published online: 8 FEB 2015 | DOI: 10.1111/bjd.13466

  69. Epidemiology and Health Services Research

    1. Relevance of congenital melanocytic naevi in vitiligo

      N. van Geel, L. Van Poucke, B. Van de Maele and R. Speeckaert

      Article first published online: 5 FEB 2015 | DOI: 10.1111/bjd.13444

      What's already known about this topic?

      • Some case reports concerning the concomitant presence of congenital melanocytic naevi (CMN), halo naevi and vitiligo have been published. However, their possible link has never been investigated in a large patient population.

      What does this study add?

      • This study provides evidence that CMN may influence the age of onset of vitiligo and trigger the development of halo naevi in patients with vitiligo.
  70. Clinical and Laboratory Investigations

    1. Identification of loci associated with late-onset psoriasis using dense genotyping of immune-related regions

      H.L. Hébert, J. Bowes, Rh.Ll. Smith, E. Flynn, R. Parslew, A. Alsharqi, N.J. McHugh, J.N.W.N. Barker, C.E.M. Griffiths, A. Barton and R.B. Warren

      Article first published online: 5 FEB 2015 | DOI: 10.1111/bjd.13340

      What's already known about this topic?

      • Chronic plaque psoriasis can be dichotomized into early-onset (onset < 40 years) and late-onset (onset ≥ 40 years) subtypes.
      • Genetic studies have so far focused on early-onset psoriasis, identifying 36 loci in white populations.
      • Late-onset psoriasis has generally been neglected in genetic studies.

      What does this study add?

      • This is the first genome-wide study to date of a late-onset psoriasis cohort.
      • There is a novel association at IL1R1, which is specific for late-onset psoriasis.
      • There is significant association of eight loci previously identified in early-onset psoriasis, demonstrating overlap between early- and late-onset psoriasis.
  71. Dermatological Surgery and Lasers

    1. Postoperative radiation therapy for extramammary Paget's disease

      M. Hata, I. Koike, H. Wada, E. Miyagi, T. Kasuya, H. Kaizu, Y. Mukai and T. Inoue

      Article first published online: 5 FEB 2015 | DOI: 10.1111/bjd.13357

      What's already known about this topic?

      • The standard treatment of extramammary Paget's disease (EMPD) is surgery, but the incidence of local recurrence is high.

      What does this study add?

      • Postoperative radiation therapy is safe and effective in establishing local control of EMPD.
      • These results suggest that radiation therapy is a promising adjuvant therapy to prevent local recurrence after surgery in patients with EMPD.
  72. Dermatopathology

    1. The stars within the melanocytic garden: unusual variants of Spitz naevi

      E. Moscarella, S. Al Jalbout, S. Piana, G. Argenziano, A. Lallas, C. Longo, R. Hofmann-Wellenhof and I. Zalaudek

      Article first published online: 18 JAN 2015 | DOI: 10.1111/bjd.13347

      What's already known about this topic?

      • Spitz naevi may present a wide spectrum of morphologies.
      • Clinical and dermoscopic features of unusual variants of Spitz naevi have been reported only rarely.

      What does this study add?

      • We describe clinical, dermoscopic and histopathological features of uncommon morphological variants of Spitz naevi, in order to raise awareness among clinicians about their peculiar patterns of presentation.
  73. Cutaneous Biology

    1. Intravenous transplantation of bone marrow mesenchymal stem cells could effectively promote vascularization and skin regeneration in mechanically stretched skin

      S.B. Zhou, C.A. Chiang, K. Liu and Q.F. Li

      Article first published online: 18 JAN 2015 | DOI: 10.1111/bjd.13251

      What's already known about this topic?

      • Skin expansion can provide clinical reconstruction with regenerated skin but the outcome is strictly limited by the skin's instinctive regenerative capacity.
      • Recent reports have indicated that intradermal injection of bone marrow mesenchymal stem cells (MSCs) have contributed to expanded skin regeneration.
      • Few studies have addressed the influence of intravenous MSC transplantation on skin regeneration induced by mechanical stretch.

      What does this study add?

      • This study reported that intravenously transplanted MSCs could be recruited to expanded skin areas and engrafted in expanded skin.
      • Migrated MSCs could effectively improve skin vascularization and promote skin regeneration.
    2. Propionibacterium species and follicular keratinocyte activation in acneic and normal skin

      A.C. Jahns, H. Eilers, R. Ganceviciene and O.A. Alexeyev

      Article first published online: 11 DEC 2014 | DOI: 10.1111/bjd.13436

      What's already known about this topic?

      • Acne vulgaris is a multifactorial inflammatory disease.
      • Hyperproliferation of keratinocytes is believed to be a major contributing factor to acne vulgaris.
      • Follicular hyperkeratinization and increased sebum production favour the colonization of Propionibacterium acnes.

      What does this study add?

      • Acne and control samples show a comparable keratinocyte proliferation status.
      • There is no link between bacterial colonization and follicular keratinocyte proliferation.
      • P. acnes and P. granulosum occur as distinct populations within the same follicle.
    3. Similar response patterns to topical minoxidil foam 5% in frontal and vertex scalp of men with androgenetic alopecia: a microarray analysis

      P. Mirmirani, M. Consolo, P. Oyetakin-White, E. Baron, P. Leahy and P. Karnik

      Article first published online: 10 DEC 2014 | DOI: 10.1111/bjd.13399

      What's already known about this topic?

      • There are regional variations in the scalp hair miniaturization seen in androgenetic alopecia (AGA).
      • Use of topical minoxidil can lead to reversal of miniaturization in the vertex scalp.

      What does this study add?

      • Frontal scalp of patients with AGA is responsive to minoxidil treatment in a manner similar to vertex scalp.
      • The hair-growth properties of minoxidil topical foam may be mediated through increased production of hair keratin-associated proteins and decreased epidermal differentiation complex and inflammatory gene expression.

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