British Journal of Dermatology

Cover image for Vol. 174 Issue 5

Early View (Online Version of Record published before inclusion in an issue)

Editor: Alex Anstey, Bangor, UK

Impact Factor: 4.275

ISI Journal Citation Reports © Ranking: 2014: 6/63 (Dermatology)

Online ISSN: 1365-2133

Associated Title(s): Clinical and Experimental Dermatology

VIEW

  1. 1 - 72
  1. Research Letters

  2. Medical Dermatology

    1. Diagnostic patch testing following tuberculosis-associated cutaneous adverse drug reactions induces systemic reactions in HIV-infected persons

      R.J. Lehloenya, G. Todd, J. Wallace, M.R. Ngwanya, R. Muloiwa and K. Dheda

      Version of Record online: 26 MAY 2016 | DOI: 10.1111/bjd.14492

      What's already known about this topic?

      • HIV-infected persons are predisposed to frequent and severe cutaneous adverse drug reactions (CADRs).
      • The utility of patch testing in the diagnosis of CADR varies with the type of CADR and the offending drug.
      • Patch testing is not well defined for tuberculosis-associated CADR in HIV-infected persons.

      What does this study add?

      • In HIV-infected persons with tuberculosis-associated CADR, patch testing reactions to first-line antituberculosis drugs seem to be associated with systemic features, not localized reactions.
  3. Research Letters

    1. Is a punch biopsy reliable in subtyping basal cell carcinoma? A systematic review

      D.J. Kadouch, A. van Haersma de With, J. Limpens, A.C. van der Wal, A. Wolkerstorfer, M.W. Bekkenk and M.A. de Rie

      Version of Record online: 26 MAY 2016 | DOI: 10.1111/bjd.14458

  4. Epidemiology

    1. Comorbidities and inpatient mortality for pemphigus in the U.S.A.

      D.Y. Hsu, J. Brieva, A.A. Sinha, S.M. Langan and J.I. Silverberg

      Version of Record online: 25 MAY 2016 | DOI: 10.1111/bjd.14463

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      What's already known about this topic?

      • Pemphigus is associated with morbidity and mortality.
      • The inpatient comorbidities and mortality of pemphigus have not been well described.

      What does this study add?

      • The present study revealed novel associations between pemphigus and numerous medical and mental health comorbidities in children and adults, including infections and autoimmune, cardiovascular, endocrine, haematological and neuropsychiatric disorders.
      • Although inpatient mortality rates for patients with pemphigus were higher than for those without pemphigus, we found substantially lower inpatient mortality rates than traditionally reported in pemphigus.
  5. Research Letters

  6. Epidemiology

    1. Predictive factors of self-reported hand eczema in adult Danes: a population-based cohort study with 5-year follow-up

      N.G. Heede, J.P. Thyssen, B.H. Thuesen, A. Linneberg and J.D. Johansen

      Version of Record online: 24 MAY 2016 | DOI: 10.1111/bjd.14476

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      What's already known about this topic?

      • Atopic dermatitis (AD), female sex, contact sensitization and wet work are known risk factors for hand eczema.
      • Knowledge about predictive factors of hand eczema in the adult general population is limited.

      What does this study add?

      • A history of AD predicts both incident and persistent hand eczema in adults.
      • Filaggrin gene (FLG) null mutations strongly predict persistent hand eczema, but the association with incident hand eczema in adults is nonsignificant.
      • Contact sensitization is significantly associated with persistent hand eczema, also in participants without AD.
  7. Review Articles

    1. Is early detection of basal cell carcinoma worthwhile? Systematic review based on the WHO criteria for screening

      I. Hoorens, K. Vossaert, K. Ongenae and L. Brochez

      Version of Record online: 24 MAY 2016 | DOI: 10.1111/bjd.14477

      What's already known about this topic?

      • Basal cell carcinoma (BCC) is the most common (skin) cancer in Europe. Its incidence is rising dramatically, and it is associated with an important direct treatment cost for healthcare budgets.
      • BCCs slowly increase in size, with a median increase in diameter of 0·5 mm over 10 weeks.
      • Delays in diagnosis and appropriate treatment are the most important underlying causes of giant BCC and metastasis.

      What does this study add?

      • Early detection and starting of adequate treatment of BCC seem to be crucial for BCC of the face, more specifically in the H-zone.
      • Small changes in size can affect treatment options (e.g. type of surgery), their effectiveness and the associated costs.
  8. Letters to the Editor

  9. Research Letters

    1. Trichoscopy as an additional tool for the differential diagnosis of tinea capitis: a prospective clinical study

      A. Brasileiro, S. Campos, J. Cabete, C. Galhardas, A. Lencastre and V. Serrão

      Version of Record online: 23 MAY 2016 | DOI: 10.1111/bjd.14413

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  10. Research letters

    1. Risk of bias does not differ between full papers and letters reporting dermatological randomized controlled trials

      D.N. Chauhan, S.R. Wilkes, S. Ratib, E. Doney, J.M. Batchelor, N.K. Rogers and H.C. Williams

      Version of Record online: 22 MAY 2016 | DOI: 10.1111/bjd.14455

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  11. Systematic Reviews

    1. The epidemiology of childhood psoriasis: a scoping review

      E. Burden-Teh, K.S. Thomas, S. Ratib, D. Grindlay, E. Adaji and R. Murphy

      Version of Record online: 22 MAY 2016 | DOI: 10.1111/bjd.14507

      What's already known about this topic?

      • The prevalence of psoriasis in children is lower than in adults, but the significant number of adults who first developed skin disease in childhood supports the frequent persistence of psoriasis into adulthood.
      • Genetic and environmental factors both play an important role in the onset of psoriasis.
      • Disease associations, such as obesity, are an important area of current research activity.

      What does this study add?

      • Mapping has shown a dramatic increase in the number of published studies over the past 25 years.
      • Studies have been concentrated in Europe, Asia and North America. These studies have largely been case series or cross-sectional studies.
      • Specific studies with standardized methodologies are needed to provide data on the frequency, clinical presentation, risk factors, associated diseases and long-term outcomes for childhood-onset psoriasis.
  12. Research Letters

    1. Parkinson disease and multiple sclerosis are not associated with autoantibodies against structural proteins of the dermal–epidermal junction

      A. Recke, A. Oei, F. Hübner, K. Fechner, J. Graf, J. Hagenah, C. May, D. Woitalla, A. Salmen, D. Zillikens, R. Gold, W. Schlumberger and E. Schmidt

      Version of Record online: 18 MAY 2016 | DOI: 10.1111/bjd.14538

  13. Translational Research

    1. Elevation of serum squamous cell carcinoma antigen 2 in patients with psoriasis: associations with disease severity and response to the treatment

      Y. Watanabe, Y. Yamaguchi, N. Komitsu, S. Ohta, Y. Azuma, K. Izuhara and M. Aihara

      Version of Record online: 18 MAY 2016 | DOI: 10.1111/bjd.14426

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      What's already known about this topic?

      • Squamous cell carcinoma antigen (SCCA) belongs to the ovalbumin–serpin family.
      • Serum SCCA level has been widely used as a tumour marker.
      • Serum SCCA level is increased in patients with psoriasis.

      What does this study add?

      • SCCA2 level was significantly higher in patients with psoriasis than healthy volunteers in both skin and serum.
      • Serum SCCA2 level was strongly correlated with psoriasis severity score and reflected treatment efficacy.
      • Expression of SCCA2 was elevated in the epidermis of patients with psoriasis and its intensity was correlated with serum SCCA2 level.
      • SCCA2 was strongly induced by T-helper (Th) 17-type cytokines in human keratinocytes.

      What is the translational message?

      • SCCA2 may be a useful biomarker in psoriasis, reflecting Th17-type inflammation.
  14. Letters to the Editor

    1. Bier anaemic spots, cyanosis with urticaria-like eruption (BASCULE) syndrome: a new entity?

      D. Bessis, É. Jeziorski, V. Rigau, P. Pralong and V. Pallure

      Version of Record online: 18 MAY 2016 | DOI: 10.1111/bjd.14589

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  15. Translational Research

    1. Zinc finger protein A20 is involved in the antipsoriatic effect of calcipotriol

      X. Liu, Y. Liu, M. Xu, J. Li, X. Teng, H. Cheng and Y. Xia

      Version of Record online: 14 MAY 2016 | DOI: 10.1111/bjd.14481

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      What's already known about this topic?

      • TNFAIP3 (encoding A20) polymorphisms are associated with the susceptibility to psoriasis.
      • A20 exhibits an anti-apoptotic effect on various types of cells, and regulates nuclear factor kappa B (NF-κB) activation.
      • Calcipotriol ameliorates psoriasis through inducing apoptosis of keratinocytes.

      What does this study add?

      • A20 expression increases in keratinocytes under psoriatic inflammation.
      • Calcipotriol suppresses A20 expression in psoriatic tissues or keratinocytes.
      • Under psoriatic inflammation, NF-κB inhibition occurs in keratinocytes with A20 downregulation induced by calcipotriol.
      • Calcipotriol promotes the binding of A20 to ring finger protein 114 (RNF114) and A20-binding inhibitor of NF-κB-1 (ABIN-1) partners, which are known to downregulate the NF-κB pathway.

      What is the translational message?

      • The A20 pathway may be a therapeutic target for treating psoriasis.
  16. Research letters

  17. General Dermatology

    1. You have full text access to this OnlineOpen article
      Psychometric properties of the Itch Numeric Rating Scale in patients with moderate-to-severe plaque psoriasis

      A.B. Kimball, A.N. Naegeli, E. Edson-Heredia, C.-Y. Lin, C. Gaich, E. Nikaï, K. Wyrwich and G. Yosipovitch

      Version of Record online: 8 MAY 2016 | DOI: 10.1111/bjd.14464

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      What's already known about this topic?

      • Itching is a profoundly distressing symptom for many patients with psoriasis, but has not been rigorously studied using validated tools for this condition.
      • The Itch Numeric Rating Scale is a single-item instrument that assesses the severity of itch due to psoriasis.

      What does this study add?

      • The Itch Numeric Rating Scale demonstrated sufficient reliability, validity and responsiveness, and appropriate interpretation standards for evaluating change over time in itch severity among patients with moderate-to-severe plaque psoriasis.
  18. Translational Research

    1. Increased expression of CXCR3 and its ligands in patients with vitiligo and CXCL10 as a potential clinical marker for vitiligo

      X. X. Wang, Q. Q. Wang, J. Q. Wu, M. Jiang, L. Chen, C. F. Zhang and L. H. Xiang

      Version of Record online: 4 MAY 2016 | DOI: 10.1111/bjd.14416

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      What's already known about this topic?

      • A T-cell-mediated immune response is responsible for melanocyte destruction in vitiligo.
      • CXCL10 is critical for the progression and maintenance of depigmentation in a mouse model of vitiligo.

      What does this study add?

      • CXCL9 and CXCL10, in parallel with their receptor, CXCR3, are present in patients with vitiligo and correlate with disease activity and severity.
      • Serum CXCL10 may be a novel biomarker in monitoring disease activity and guiding treatment of progressive vitiligo.

      What is the translational message?

      • Blocking the CXCL10/CXCR3 chemotactic mechanism may present a new form of therapy for progressive vitiligo.
  19. Review Articles

    1. You have full text access to this OnlineOpen article
      Development of core outcome sets in hidradenitis suppurativa: systematic review of outcome measure instruments to inform the process

      J.R. Ingram, S. Hadjieconomou and V. Piguet

      Version of Record online: 2 MAY 2016 | DOI: 10.1111/bjd.14475

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      What's already known about this topic?

      • The recent hidradenitis suppurativa (HS) Cochrane review identified heterogeneity of outcome measure instruments as an important obstacle in the design of future HS trials.
      • The Harmonising Outcome Measures for Eczema (HOME) initiative provides a roadmap for developing a core outcomes set in HS.

      What does this study add?

      • Twenty-seven of the 30 outcome measure instruments used in HS randomized controlled trials are not supported by any formal validation data.
      • Where available, validation evidence is generally of relatively low methodological quality, or remains incomplete, and so no instruments can be fully recommended currently.
  20. General Dermatology

    1. N-Acyl ethanolamide and eicosanoid involvement in irritant dermatitis

      A.C. Kendall, S.M. Pilkington, G. Sassano, L.E. Rhodes and A. Nicolaou

      Version of Record online: 28 APR 2016 | DOI: 10.1111/bjd.14521

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      What's already known about this topic?

      • Bioactive lipid mediators are emerging as important players in cutaneous homeostasis and inflammation.
      • Irritant dermatitis is a considerable problem in dermatology/occupational health, and would benefit from greater understanding of the role of lipids in the skin's response to irritants.

      What does this study add?

      • Specific eicosanoid and endocannabinoid mediators contribute to the inflammatory response to the common irritant sodium lauryl sulfate but not to ultraviolet radiation challenge matched to generate comparable erythema.
      • Our findings provide insights into pathways involved in irritant dermatitis, with potential translation to novel treatments and new means for assessing contact irritants.
  21. Systematic Reviews

    1. Education to improve quality of life of people with chronic inflammatory skin conditions: a systematic review of the evidence

      K. Pickett, G. Frampton and E. Loveman

      Version of Record online: 28 APR 2016 | DOI: 10.1111/bjd.14435

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      What's already known about this topic?

      • People with chronic inflammatory skin conditions can experience poor health-related quality of life (HRQoL).
      • There is mixed evidence about whether patient education improves HRQoL.

      What does this study add?

      • Education often focuses on information about a condition and its treatment. This systematic review examines outcomes of education that specifically aims to improve HRQoL or includes elements that could improve HRQoL.
      • The limited available evidence shows inconsistent HRQoL effects and the need for more theoretically based interventions.
  22. Translational Research

    1. Serum and salivary IgG and IgA antibodies to desmoglein 3 in mucosal pemphigus vulgaris

      S. Ali, C. Kelly, S.J. Challacombe, A.N.A. Donaldson, B.S. Bhogal and J.F. Setterfield

      Version of Record online: 27 APR 2016 | DOI: 10.1111/bjd.14410

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      What's already known about this topic?

      • The use of serum to test for IgG autoantibodies to desmoglein (Dsg)3 by enzyme-linked immunosorbent assay has been well documented.
      • Salivary IgG anti-Dsg3 antibodies have been previously detected in three studies in pemphigus vulgaris (PV) and have been proposed as a diagnostic marker.

      What does this study add?

      • This study demonstrates that detection of salivary antibodies provides a practical alternative to serum in the diagnosis of PV. Salivary antibodies may also be used for the monitoring of disease activity in patients with PV.
      • Both IgG and IgA serum antibodies to Dsg3 are detected in IgG-driven PV. Further investigation is needed to understand the role of IgA in the pathogenesis of PV.

      What is the translational message?

      • The simplicity of obtaining a whole saliva sample and the demonstration that anti-Dsg3 IgG antibodies can be easily detected suggests that saliva may become a useful diagnostic screening test for PV.
      • As titres are related to disease activity, repeated noninvasive sampling offers the possibility of routine remote monitoring of disease.
  23. Research Letters

    1. Methotrexate in psoriasis under real-world conditions: long-term efficacy and tolerability

      J. West, S. Ogston, C. Palmer, C. Fleming, R. Dawe, V. Kumar, S. Waterston and J. Foerster

      Version of Record online: 26 APR 2016 | DOI: 10.1111/bjd.14452

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  24. Clinical Trials

    1. Oral alitretinoin treatment in patients with palmoplantar pustulosis inadequately responding to standard topical treatment: a randomized phase II study

      K. Reich, O. Graff and N. Mehta

      Version of Record online: 26 APR 2016 | DOI: 10.1111/bjd.14401

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      What's already known about this topic?

      • Alitretinoin is a retinoid X receptor and retinoid A receptor agonist with effects on cutaneous inflammation and hyperkeratinization.
      • Findings from earlier uncontrolled studies of alitretinoin indicate that it could be a meaningful treatment option for palmoplantar pustulosis.

      What does this study add?

      • Although the results were unexpected based on previous studies of alitretinoin in the treatment of palmoplantar pustulosis, this study provided no evidence to support further exploration of alitretinoin in the treatment of severe palmoplantar pustulosis.
  25. Translational Research

    1. Characterization of patients at high risk of melanoma in Austria

      C. Müller, J. Wendt, S. Rauscher, S. Burgstaller-Muehlbacher, R. Sunder-Plassmann, C. Scheurecker, E. Richtig, I. Fae, G. Fischer, H. Pehamberger and I. Okamoto

      Version of Record online: 26 APR 2016 | DOI: 10.1111/bjd.14407

      What's already known about this topic?

      • Melanoma risk is determined by environmental and genetic risk factors.
      • The frequency and type of disease-causing gene mutations vary between different countries.

      What does this study add?

      • This is the first comprehensive description of Austrian patients at high risk of melanoma.
      • The heterogeneity of the different subgroups suggests diverse pathways.
      • We present functional prediction of MC1R and CDK4 variants with unknown biological significance in high-risk patients, and three novel cases with MITF variants in high-risk patients.

      What is the translational message?

      • Identification of high-risk individuals helps to reduce mortality.
      • The risk of melanoma is comprised of a complex interplay between genetic and environmental factors; however, genetic mutations associated with melanoma might differ from country to country.
      • Knowledge of these mutations and adjustment of criteria for testing could be required for adequate risk assessments.
    2. Common and rare CARD14 gene variants affect the antitumour necrosis factor response among patients with psoriasis

      P. Coto-Segura, D. González-Fernández, A. Batalla, J. Gómez, L. González-Lara, R. Queiro, B. Alonso, S. Iglesias and E. Coto

      Version of Record online: 25 APR 2016 | DOI: 10.1111/bjd.14461

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      What's already known about this topic?

      • Patients with psoriasis treated with antitumour necrosis factor (anti-TNF) agents (and other biological therapies) exhibit a heterogeneous response.
      • This could be explained partly by the variability in genes that encode components of immunological pathways.
      • Rare and common CARD14 variants have been linked to the risk for psoriasis, but no study about the effect on anti-TNF response has been reported.

      What does this study add?

      • Our study showed that the CARD14 rs11652075 polymorphism (Arg820Trp) was associated with the response to anti-TNF agents among patients with psoriasis.
      • The genotype that increased the risk for psoriasis was also a significant predictor of a better anti-TNF response, measured as ≥ 75% improvement in Psoriasis Area and Severity Index at week 24.

      What is the translational message?

      • Variants of the CARD14 gene (a regulator of nuclear factor-κB-mediated pathways) have been associated with the overall risk of developing psoriasis in case–control studies.
      • In this work, we show that CARD14 variants are also related to the response to anti-TNF agents.
      • If the results are confirmed by others, the analysis of this gene might help dermatologists to optimize treatment with anti-TNF biological drugs.
    3. Skin expression of mammalian target of rapamycin and forkhead box transcription factor O1, and serum insulin-like growth factor-1 in patients with acne vulgaris and their relationship with diet

      N.F. Agamia, D.M. Abdallah, O. Sorour, B. Mourad and D.N. Younan

      Version of Record online: 20 APR 2016 | DOI: 10.1111/bjd.14409

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      What's already known about this topic?

      • A high-glycaemic-load diet and insulin-like growth factor-1 play roles in the induction of acne.
      • Increased mammalian target of rapamycin (mTOR)C1 signalling has been reported in patients with acne compared with healthy controls.

      What does this study add?

      • This study provides immunohistochemical evidence of increased cytoplasmic expression of the metabolic transcription factor FoxO1 and increased expression of mTOR in the skin of patients with acne.
      • We provide experimental evidence supporting the hypothesis of decreased nuclear FoxO1 signalling in patients with acne.

      What is the translational message?

      • Nutritional therapy for acne should (i) normalize total calorie intake, (ii) lower glycaemic load and (iii) restrict total dairy protein consumption.
      • Understanding nutrient signalling may help dermatologists to understand the central role of the Western diet in the pathogenesis and treatment of acne.
      • Our results may offer novel therapeutic strategies for the treatment of acne based on upregulation of nuclear FoxO1.
  26. Research Letters

    1. PSTPIP1 gene mutation in a pyoderma gangrenosum, acne and suppurative hidradenitis (PASH) syndrome

      X. Calderón-Castrat, D. Bancalari-Díaz, C. Román-Curto, A. Romo-Melgar, D. Amorós-Cerdán, L.A. Alcaraz-Mas, E. Fernández-López and J. Cañueto

      Version of Record online: 19 APR 2016 | DOI: 10.1111/bjd.14383

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  27. General Dermatology

    1. Carbon dioxide laser ablation of basal cell carcinoma with visual guidance by reflectance confocal microscopy: a proof-of-principle pilot study

      B.P. Hibler, H. Sierra, M. Cordova, W. Phillips, M. Rajadhyaksha, K.S. Nehal and A.M. Rossi

      Version of Record online: 19 APR 2016 | DOI: 10.1111/bjd.14414

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      What's already known about this topic?

      • Nonsurgical treatment including laser ablation of skin cancer is limited by lack of histologically confirmed clearance.
      • Reflectance confocal microscopy provides noninvasive, in vivo imaging of skin with cellular-level resolution

      What does this study add?

      • Confocal microscopy can effectively map tumour margins preablation and also detect residual tumour postablation.
      • Carbon dioxide laser ablation guided by confocal microscopy may represent a suitable alternative treatment for low-risk basal cell carcinoma in nonsurgical candidates.
  28. Letters to the Editor

  29. Translational Research

    1. IgE and FcεRI are highly expressed on innate cells in psoriasis

      K-X. Yan, Q. Huang, X. Fang, Z-H. Zhang, L. Han, K. Gadaldi, K-F. Kang, Z-Z. Zheng, J-H. Xu and N. Yawalkar

      Version of Record online: 18 APR 2016 | DOI: 10.1111/bjd.14459

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      What's already known about this topic?

      • Serum total IgE levels are elevated in patients with psoriasis.

      What does this study add?

      • The expression of IgE and FcεRI was particularly enhanced on innate cells in psoriatic lesions. The numbers of IgE+ and FcεRI+ cells in psoriatic lesions significantly decreased after treatment with ustekinumab.

      What is the translational message?

      • IgE-mediated mechanisms may perpetuate cutaneous inflammation in a subset of patients with psoriasis.
  30. Letters to the Editor

    1. Short-contact, low-dose methyl aminolaevulinate photodynamic therapy for acne vulgaris

      C. Dessinioti, S. Masouri, E. Drakaki, A. Katsambas and C. Antoniou

      Version of Record online: 18 APR 2016 | DOI: 10.1111/bjd.14460

  31. Research Letters

    1. Net-like superficial vascular malformation: clinical description and evidence for lymphatic origin

      L. Noguera-Morel, S.L. Stein, G. Xirotagaros, A. Hernández-Martín, I. de Prada, I.J. Frieden, L. Requena and A. Torrelo

      Version of Record online: 18 APR 2016 | DOI: 10.1111/bjd.14404

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  32. General Dermatology

    1. Multicentre study on inflammatory skin diseases from The International Confocal Working Group: specific confocal microscopy features and an algorithmic method of diagnosis

      M. Ardigo, C. Longo, S. Gonzalez and The International Confocal Working Group Inflammatory Skin Diseases Project

      Version of Record online: 18 APR 2016 | DOI: 10.1111/bjd.14516

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      What's already known about this topic?

      • Reflectance confocal microscopy has been used successfully for the evaluation of several inflammatory skin diseases.

      What does this study add?

      • Reflectance confocal microscopy provides features useful for diagnosis and differential diagnosis of the major inflammatory skin diseases.
      • An algorithmic method originating from multivariate analysis can be used for the diagnosis.
  33. Research letters

    1. Drug survival for azathioprine and enteric-coated mycophenolate sodium in a long-term daily practice cohort of adult patients with atopic dermatitis

      J. van der Schaft, K. Politiek, J.M.P.A. van den Reek, W. Kievit, E.M.G.J. de Jong, C.A.F.M. Bruijnzeel-Koomen, M.L.A. Schuttelaar and M.S. de Bruin-Weller

      Version of Record online: 17 APR 2016 | DOI: 10.1111/bjd.14398

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  34. Case Reports

    1. Topical sodium metabisulfite for the treatment of calcinosis cutis: a promising new therapy

      P. del Barrio-Díaz, C. Moll-Manzur, S. Álvarez-Veliz and C. Vera-Kellet

      Version of Record online: 17 APR 2016 | DOI: 10.1111/bjd.14412

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      What's already known about this topic?

      • Calcinosis cutis is a chronic calcium-mediated disease that causes significant morbidity for patients.
      • Multiple treatments have been tried, many of them with varying results and side-effects. To date, no standard treatment has been generally accepted.

      What does this study add?

      • Topical sodium metabisulfite is a new, inexpensive emerging therapy that should be considered as a valid alternative treatment in patients with calcinosis cutis, especially in countries where topical sodium thiosulfate is not available.
  35. Epidemiology

    1. An estimation of the incidence of tuberous sclerosis complex in a nationwide retrospective cohort study (1997–2010)

      C.-H. Hong, H.-P. Tu, J.-R. Lin and C.-H. Lee

      Version of Record online: 17 APR 2016 | DOI: 10.1111/bjd.14415

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      What's already known about this topic?

      • Patients with tuberous sclerosis complex (TSC) develop systemic hamartomas with significant psychosocial burdens.
      • Two small epidemiological studies have estimated the incidence of TSC to be 0·28–0·56 per 100 000 person-years (PY) in the U.S.A.

      What does this study add?

      • This 14-year-long longitudinal study estimated the incidence of TSC in Taiwan to be 0·153 per 100 000 PY.
      • The prevalence of TSC in 2010 in Taiwan was 1·58 in 100 000.
      • A significantly lower risk of peptic ulcer is found in patients with TSC compared with healthy controls.
  36. Case Reports

    1. Two cases of overlap severe cutaneous adverse reactions to benznidazole treatment for asymptomatic Chagas disease in a nonendemic country

      J. González-Ramos, L. Noguera-Morel, H.Y. Tong, E. Ramírez, E. Ruiz-Bravo, T. Bellón, R. Cabañas, L. Cachafeiro and P. Herranz-Pinto

      Version of Record online: 7 APR 2016 | DOI: 10.1111/bjd.14451

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      What's already known about this topic?

      • Cutaneous reactions to benznidazole are common; however, severe cases have rarely been reported.

      What does this study add?

      • Benznidazole may induce potentially life-threatening severe cutaneous adverse reactions.
      • There should be greater awareness among physicians of this newly reported risk.
  37. Clinical Trials

    1. You have full text access to this OnlineOpen article
      A randomized phase 2b trial of baricitinib, an oral Janus kinase (JAK) 1/JAK2 inhibitor, in patients with moderate-to-severe psoriasis

      K.A. Papp, M.A. Menter, M. Raman, D. Disch, D.E. Schlichting, C. Gaich, W. Macias, X. Zhang and J.M. Janes

      Version of Record online: 5 APR 2016 | DOI: 10.1111/bjd.14403

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      What's already known about this topic?

      • Psoriasis is a common, chronic, immune-mediated inflammatory skin disease.
      • Key cytokines involved in the pathogenesis of psoriasis use the Janus kinase–signal transducer and activator of transcription (JAK-STAT) pathway.
      • New safe and effective therapies are needed for patients.

      What does this study add?

      • Baricitinib, a selective JAK1/JAK2 inhibitor, demonstrates clinical efficacy in the treatment of psoriasis.
      • Baricitinib was well tolerated over the 24-week trial period.
  38. General Dermatology

    1. You have full text access to this OnlineOpen article
      The 2016 International League of Dermatological Societies' revised glossary for the description of cutaneous lesions

      A. Nast, C.E.M. Griffiths, R. Hay, W. Sterry and J.L. Bolognia

      Version of Record online: 3 APR 2016 | DOI: 10.1111/bjd.14419

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      What's already known about this topic?

      • A unifying language and precise descriptions are key to the practice of dermatology.
      • The International League of Dermatological Societies (ILDS) first published a ‘Glossary of basic dermatology lesions’ in 1987.

      What does this study add?

      • This is an entirely updated and revised version of the 1987 ILDS glossary.
      • The revised nomenclature is written with both dermatologists and nondermatologists in mind.
  39. Medical Dermatology

    1. Calculation of cut-off values based on the Autoimmune Bullous Skin Disorder Intensity Score (ABSIS) and Pemphigus Disease Area Index (PDAI) pemphigus scoring systems for defining moderate, significant and extensive types of pemphigus

      C. Boulard, S. Duvert Lehembre, C. Picard-Dahan, J.S. Kern, G. Zambruno, C. Feliciani, B. Marinovic, P. Vabres, L. Borradori, C. Prost-Squarcioni, B. Labeille, M.A. Richard, S. Ingen-Housz-Oro, E. Houivet, V.P. Werth, D.F. Murrell, M. Hertl, J. Benichou, P. Joly and on behalf of the International Pemphigus Study Group

      Version of Record online: 3 APR 2016 | DOI: 10.1111/bjd.14405

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      What's already known about this topic?

      • The Autoimmune Bullous Skin Disorder Intensity Score (ABSIS) and Pemphigus Disease Area Index (PDAI) are new scoring systems to measure pemphigus activity.
      • The use of these scores in clinical practice is limited by the absence of cut-off values.

      What does this study add?

      • Cut-off values distinguishing moderate, significant and extensive pemphigus were 15 and 45 for PDAI, and 17 and 53 for ABSIS.
      • These disease activity subgroups should help physicians in the management of patients with pemphigus.
  40. Letters to the Editor

  41. Research Letters

  42. Letters to the Editor

  43. Medical Dermatology

    1. Clinical significance of serum YKL-40 in Behçet disease

      J. Seo, Y. Ahn, Z. Zheng, B.O. Kim, M.J. Choi, D. Bang and D.Y. Kim

      Version of Record online: 23 MAR 2016 | DOI: 10.1111/bjd.14376

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      What's already known about this topic?

      • YKL-40, secreted by activated macrophages and neutrophils, is a potential biomarker of inflammation and endothelial dysfunction.
      • Behçet disease (BD) is a chronic multisystemic inflammatory disease, characterized by neutrophil hyperactivation and endothelial injury with subsequent dysfunction.

      What does this study add?

      • Serum YKL-40 levels are increased in patients with BD and positively correlate with disease activity.
      • YKL-40 may play a role in the pathophysiology of BD and could provide a useful marker for monitoring patients with BD.
  44. Research Letters

    1. You have full text access to this OnlineOpen article
      The Predict Study: low risk for digital ulcer development in patients with systemic sclerosis with increasing disease duration and lack of topoisomerase-1 antibodies

      N. Hunzelmann, G. Riemekasten, M.O. Becker, P. Moinzadeh, A. Kreuter, I. Melchers, U. Mueller-Ladner, F. Meier, M. Worm, H. Lee, I. Herrgott, C. Pfeiffer, G. Fierlbeck, J. Henes, A. Juche, G. Zeidler, H. Mensing, C. Günther, M. Sárdy, H. Burkhardt, M. Koehm, K. Kuhr, T. Krieg and C. Sunderkötter

      Version of Record online: 20 MAR 2016 | DOI: 10.1111/bjd.14367

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  45. Case Reports

    1. [18F]-Fluorodeoxy-d-glucose uptake-positive seborrhoeic keratosis on positron emission tomography may result from high expression of glucose transporter

      T. Kariya, Y. Kato, A. Kanzaki, Y. Kanda, T. Ohara and R. Tsuboi

      Version of Record online: 20 MAR 2016 | DOI: 10.1111/bjd.14421

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      What's already known about this topic?

      • [18F]-Fluorodeoxy-d-glucose (FDG) positron emission tomography–computed tomography (PET-CT) is known to be highly accurate in differentiating benign lesions from malignant lesions.
      • In rare cases, benign tumours, viral infections and sarcoidosis of the skin have been reported to show FDG uptake, but the mechanism remains unclear.

      What does this study add?

      • We report, for the first time, a case of seborrhoeic keratosis (SK) with increased FDG uptake.
      • The expression of glucose transporter (GLUT)1 and GLUT3 was higher in PET- positive SK than in PET-negative SK or in normal skin.
      • High expression of GLUT1 and GLUT3 in benign tumours like SK, as in this case, might be associated with the uptake of FDG.
  46. Letters to the Editor

    1. Successful rapid subcutaneous desensitization to anakinra in a case of delayed-type hypersensitivity reaction

      V. Leroy, E. Lazaro, A.-S. Darrigade, A. Taïeb, B. Milpied and J. Seneschal

      Version of Record online: 20 MAR 2016 | DOI: 10.1111/bjd.14454

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  47. Research Letters

    1. Evaluation of learning disabilities in segmental neurofibromatosis

      E. Marmottant-Debled, C. Chiaverini, C. Fossoud, T. Passeron, S. Barbarot and J.-P. Lacour

      Version of Record online: 20 MAR 2016 | DOI: 10.1111/bjd.14436

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    2. Atopic dermatitis (eczema) in US female nurses: lifestyle risk factors and atopic comorbidities

      A.M. Drucker, W.-Q. Li, L. Lin, E. Cho, T. Li, C.A. Camargo Jr and A.A. Qureshi

      Version of Record online: 18 MAR 2016 | DOI: 10.1111/bjd.14373

    3. Bullous pemphigoid suggestive of complement-independent blister formation with anti-BP180 IgG4 autoantibodies

      T. Dainichi, W. Nishie, Y. Yamagami, H. Sonobe, H. Ujiie, Y. Kaku and K. Kabashima

      Version of Record online: 18 MAR 2016 | DOI: 10.1111/bjd.14411

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  48. Case Reports

    1. Extensive tumoral melanosis associated with ipilimumab-treated melanoma

      K. Staser, D. Chen, J. Solus, I.S. Rosman, A. Schaffer, L. Cornelius, G.P. Linette and R.C. Fields

      Version of Record online: 18 MAR 2016 | DOI: 10.1111/bjd.14474

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      What's already known about this topic?

      • Limited tumoral melanosis occurs in the context of regressed melanoma.
      • Ipilimumab activates the immune system and promotes tumour killing.

      What does this study add?

      • This study shows tumoral melanosis to an extent previously not described.
      • This extensive melanosis occurred in the context of ipilimumab treatment, suggesting that activated immunity may result in aggressive melanophagocytosis.
  49. Letters to the Editor

  50. Translational Research

    1. Infiltration of M2-polarized macrophages in infected lymphatic malformations: possible role in disease progression

      W. Zhang, K.-F. He, J.-G. Yang, J.-G. Ren, Y.-F. Sun, J.-H. Zhao and Y.-F. Zhao

      Version of Record online: 15 MAR 2016 | DOI: 10.1111/bjd.14471

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      What's already known about this topic?

      • Infection in lymphatic malformations (LMs) promotes the development of the disease.
      • Tertiary lymphoid organs (TLOs) are found in most LMs.
      • Macrophages intensively promote lymphangiogenesis in pathological conditions.

      What does this study add?

      • M2-polarized macrophages are increased in LMs compared with skin tissues.
      • A close relationship between M2-polarized macrophages and TLOs was uncovered in LMs.
      • M2-polarized macrophages and TLOs might contribute to the progression of LMs after infection.

      What is the translational message?

      • Infection or inflammation in LMs indicated poor prognosis of the disease.
      • Targeting M2-polarized macrophages might be a promising therapy for LMs.
      • Targeting TLO formation might alleviate the progression of LMs by reducing macrophage recruitment and lymphatic vessel formation.
  51. Letters to the Editor

  52. Medical Dermatology

    1. Pathophysiology of pruritus in primary localized cutaneous amyloidosis

      H.L. Tey, T. Cao, L.A. Nattkemper, V.W.D. Tan, Z.A.D. Pramono and G. Yosipovitch

      Version of Record online: 15 MAR 2016 | DOI: 10.1111/bjd.14391

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      What's already known about this topic?

      • Itch is frequently associated with primary localized cutaneous amyloidosis (PLCA) and can be debilitating; its pathophysiology is unknown.

      What does this study add?

      • Small-fibre neuropathy is present in PLCA.
      • Pruritus in PLCA is likely associated with hypersensitivity of cutaneous nerve fibres, which may be related to an increased expression of epidermal interleukin (IL)-31 receptors.
      • Targeting IL-31 receptors is a potential therapeutic approach.
  53. Epidemiology

    1. Atopic dermatitis is not associated with actinic keratosis: cross-sectional results from the Rotterdam study

      E. Hajdarbegovic, H. Blom, J.A.C. Verkouteren, A. Hofman, L.M. Hollestein and T. Nijsten

      Version of Record online: 14 MAR 2016 | DOI: 10.1111/bjd.14423

      What's already known about this topic?

      • Patients with severe atopic dermatitis (AD) treated with ultraviolet therapy and immunosuppressants are at an increased risk of keratinocyte malignancies.

      What does this study add?

      • Community-dwelling, average patients with AD do not have more actinic keratoses or keratinocyte cancers than those without AD.
      • There is no support for extra actinic keratosis and keratinocyte cancer screening in patients with mild-to-moderate AD.
  54. Research Letters

  55. Case Reports

    1. Amelioration of junctional epidermolysis bullosa due to exon skipping

      C. Kowalewski, J. Bremer, A. Gostynski, K. Wertheim-Tysarowska, K. Wozniak, J. Bal, M.F. Jonkman and A.M.G. Pasmooij

      Version of Record online: 6 MAR 2016 | DOI: 10.1111/bjd.14374

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      What's already known about this topic?

      • Revertant mosaicism is a naturally occurring event that relies on the spontaneous correction of a pathogenic mutation.
      • Antisense oligonucleotide-mediated exon skipping is a new gene therapy that is under investigation for the treatment of epidermolysis bullosa.

      What does this study add?

      • We identified a patient with junctional epidermolysis bullosa with two correction mechanisms both leading to in-frame skipping of the mutated exon 49 in the COL17A1 gene – (i) premature termination codon-induced exon skipping and (ii) correction of the inherited mutation by a spontaneous somatic splice-site mutation.
      • Our data support the use of antisense oligonucleotide-mediated exon skipping as a therapeutic approach for epidermolysis bullosa.
  56. Research Letters

    1. Skin and soft tissue infections and acute kidney injury: a systematic review

      S.R. Wilkes, E. Burden-Teh, F. Robertson, D. Grindlay and N.M. Selby

      Version of Record online: 3 MAR 2016 | DOI: 10.1111/bjd.14368

    2. Ten years of DNA diagnostics of epidermolysis bullosa in the Czech Republic

      L. Kopečková, H. Bučková, J. Kýrová, R. Gaillyová, J. Němečková, B. Jeřábková, K. Veselý, K. Stehlíková and L. Fajkusová

      Version of Record online: 1 MAR 2016 | DOI: 10.1111/bjd.14370

  57. Letters to the Editor

    1. Bimatoprost solution 0·03% topical application to the eyelid margin for the treatment of eyelash hypotrichosis

      N.R. Arujuna, E.J. Topham, L.R. Atkinson, S.M.C. George, E.K. Derrick and P.B.J. Farrant

      Version of Record online: 1 MAR 2016 | DOI: 10.1111/bjd.14472

  58. General Dermatology

    1. Airborne formaldehyde causes skin barrier dysfunction in atopic dermatitis

      J. Kim, Y. Han, J.H. Ahn, S.W. Kim, S.I. Lee, K.H. Lee and K. Ahn

      Version of Record online: 28 FEB 2016 | DOI: 10.1111/bjd.14357

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      What's already known about this topic?

      • For the proper management of atopic dermatitis (AD), aggravating factors in the environment must be identified and controlled.
      • For example, foods, inhalant allergens, and microorganisms such as bacteria and viruses are well-known factors that can exacerbate AD symptoms.
      • Epidemiological studies have implicated air pollutants and their associated hazardous effects in AD, but these studies have not provided direct evidence for causality.

      What does this study add?

      • We used a provocation test device that we developed for topical stimulation of the skin in children, and found that airborne formaldehyde increases transepidermal water loss and skin pH in healthy children and more prominently in patients with AD.
      • We revealed the causal relationship between airborne formaldehyde and skin barrier dysfunction in children with AD.
      • Exposure to airborne formaldehyde must be avoided to prevent aggravation of AD.
  59. Review Articles

    1. Cutaneous manifestations of Helicobacter cinaedi: a review

      S. Shimizu and H. Shimizu

      Version of Record online: 18 FEB 2016 | DOI: 10.1111/bjd.14353

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      What's already known about this topic?

      • Helicobacter cinaedi causes bacteraemia and cellulitis in immunodeficient individuals; however, details of the cutaneous manifestations and their management are not fully described.

      What does this study add?

      • The cutaneous manifestations, epidemiology and management of H. cinaedi infection are described in detail. Helicobacter cinaedi cellulitis, which appears as multiple painful infiltrated erythemas on the extremities, is the most common cutaneous symptom of H. cinaedi bacteraemia.
  60. Case Reports

    1. Kaposi sarcoma secondary to endogenous adrenocorticotropic hormone-dependent Cushing syndrome

      A. Mayor-Ibarguren, M.C. Roldán-Puchalt, T. Sancho-Bueso, C. Pérez-López, J. Álvarez-Linera, R. Frutos, C. Álvarez-Escolá, R. Regojo-Zapata, M.J. Beato-Merino, P. Herranz-Pinto and B. Lecumberri

      Version of Record online: 11 FEB 2016 | DOI: 10.1111/bjd.14360

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      What's already known about this topic?

      • Kaposi sarcoma (KS) is an angioproliferative disorder related to human herpesvirus 8 infection and immune dysfunction.

      What does this study add?

      • We report a case of a multicentric advanced KS secondary to Cushing syndrome due to an adrenocorticotropic hormone-secreting pituitary microadenoma.
      • This association has rarely been reported, and this case adds evidence to include endogenous Cushing syndrome as a possible cause of KS.
  61. Research Letters

    1. The influence of religious/spiritual well-being on quality of life in dermatological disease

      H.F. Unterrainer, M. Lukanz, M. Pilch, S. Scharf, M. Glawischnig-Goschnik, N. Wutte, R. Fink-Puches and E. Aberer

      Version of Record online: 28 JAN 2016 | DOI: 10.1111/bjd.14359

  62. Scholarly Reviews

    1. Pyoderma gangrenosum and Sweet syndrome: the prototypic neutrophilic dermatoses

      D. Wallach and M.-D. Vignon-Pennamen

      Version of Record online: 22 JUL 2015 | DOI: 10.1111/bjd.13955

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      What's already known about this topic?

      • Pyoderma gangrenosum and Sweet syndrome are the prototypic conditions of the vast group of the neutrophilic dermatoses, characterized by an aseptic infiltration of the skin by polymorphonuclear leucocytes.
      • A similar infiltration may also occur in internal organs, defining the neutrophilic disease.
      • The principles of the management of patients with a neutrophilic disease have been properly described.

      What does this study add?

      • The genetic and molecular mechanisms of neutrophilic inflammation are currently poorly understood.
      • They may be similar to the mechanisms of the monogenic autoinflammatory diseases, which are among the rare causes of neutrophilic dermatoses.

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