British Journal of Dermatology

Cover image for Vol. 174 Issue 6

Early View (Online Version of Record published before inclusion in an issue)

Editor: Alex Anstey, Bangor, UK

Impact Factor: 4.317

ISI Journal Citation Reports © Ranking: 2015: 5/61 (Dermatology)

Online ISSN: 1365-2133

Associated Title(s): Clinical and Experimental Dermatology

VIEW

  1. 1 - 81
  1. Translational Research

    1. Antimelanogenic effects of luteolin 7-sulfate isolated from Phyllospadix iwatensis Makino

      J.Y. Kwak, J.K. Seok, H.-J. Suh, Y.-H. Choi, S.S. Hong, D.S. Kim and Y.C. Boo

      Version of Record online: 28 JUN 2016 | DOI: 10.1111/bjd.14496

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      What's already known about this topic?

      • Previous efforts to develop antimelanogenic agents have investigated the activity of various plants against mushroom tyrosinase. However, this approach is not appropriate because of the inherent differences between mushroom and human tyrosinases.

      What does this study add?

      • This study screened 50 marine plants for human tyrosinase inhibitory effects and found that Phyllospadix iwatensis extract and its constituent, luteolin 7-sulfate, inhibited human tyrosinase activity and attenuated melanin synthesis in B16/F10 cells and human epidermal melanocytes.

      What is the translational message?

      • Marine plants have attracted attention as under-researched resources for bioactive compounds, and this study demonstrates that luteolin 7-sulfate isolated from Phyllospadix iwatensis Makino, a kind of seagrass, is a more potent and safer inhibitor of cellular melanin synthesis than luteolin.
      • If these findings are confirmed by clinical studies, the flavonoid sulfate may be useful for the control of unwanted skin pigmentation due to excessive melanin synthesis.
  2. Book Reviews

  3. Clinical Trials

    1. You have full text access to this OnlineOpen article
      A randomized, double-blind, phase III, multicentre study to evaluate the safety and efficacy of BF-200 ALA (Ameluz®) vs. placebo in the field-directed treatment of mild-to-moderate actinic keratosis with photodynamic therapy (PDT) when using the BF-RhodoLED® lamp

      U. Reinhold, T. Dirschka, R. Ostendorf, R. Aschoff, C. Berking, W.G. Philipp-Dormston, S. Hahn, K. Lau, A. Jäger, B. Schmitz, H. Lübbert and R.-M. Szeimies

      Version of Record online: 25 JUN 2016 | DOI: 10.1111/bjd.14498

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      What's already known about this topic?

      • BF-200 ALA is an exceptionally effective, well-tolerated drug for photodynamic therapy (PDT) of actinic keratosis (AK).
      • AK affects extended skin areas and requires field-directed treatment.
      • PDT with BF-200 ALA is most effective with narrowband light-emitting diode lamps.

      What does this study add?

      • This study evaluates the safety and efficacy of BF-200 ALA when used together with the BF-RhodoLED lamp for the field-directed treatment of AK.
      • This trial demonstrates a strong rejuvenation effect of PDT with BF-200 ALA on an entire treatment field.
      • Our results show that field-directed therapy with BF-200 ALA and BF-RhodoLED lamp is highly effective and well tolerated for multiple mild-to-moderate AK lesions.
  4. Letters to the Editor

  5. Medical Dermatology

    1. Body mass index predicts discontinuation due to ineffectiveness and female sex predicts discontinuation due to side-effects in patients with psoriasis treated with adalimumab, etanercept or ustekinumab in daily practice: a prospective, comparative, long-term drug-survival study from the BioCAPTURE registry

      J. Zweegers, J.M.P.A. van den Reek, P.C.M. van de Kerkhof, M.E. Otero, A.L.A. Kuijpers, M.I.A. Koetsier, W.P. Arnold, M.A.M. Berends, L. Weppner-Parren, P.M. Ossenkoppele, M.D. Njoo, J.M. Mommers, P.P.M. van Lümig, R.J.B. Driessen, W. Kievit and E.M.G.J. de Jong

      Version of Record online: 25 JUN 2016 | DOI: 10.1111/bjd.14552

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      What's already known about this topic?

      • Drug survival of biologics for psoriasis has been analysed, but few publications used prospective multicentre daily-practice data.
      • These studies found that ustekinumab had the highest confounder-corrected overall drug survival, but they did not split survival analysis for the different biologics or for different reasons of discontinuation.
      • Different predictors for overall drug survival were found in prospective and retrospective studies.

      What does this study add?

      • This study reports on a longer period of drug survival than previous studies.
      • Ustekinumab has a higher confounder-corrected drug survival and higher survival for discontinuation due to ineffectiveness and side-effects than adalimumab and etanercept.
      • Higher body mass index (BMI) predicts discontinuation due to ineffectiveness in etanercept and ustekinumab, and female sex is a consistent predictor for discontinuation due to side-effects in all three biologics.
  6. Book Reviews

  7. Clinical Trials

    1. You have full text access to this OnlineOpen article
      A prospective phase III, randomized, double-blind, placebo-controlled study of brodalumab in patients with moderate-to-severe plaque psoriasis

      K.A. Papp, K. Reich, C. Paul, A. Blauvelt, W. Baran, C. Bolduc, D. Toth, R.G. Langley, J. Cather, A.B. Gottlieb, D. Thaçi, J.G. Krueger, C.B. Russell, C.E. Milmont, J. Li, P.A. Klekotka, G. Kricorian and A. Nirula

      Version of Record online: 23 JUN 2016 | DOI: 10.1111/bjd.14493

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      What's already known about this topic?

      • Anti-interleukin (anti-IL)-17 receptor A and anti-IL-17A antibodies have been shown to be efficacious in treating patients with moderate-to-severe plaque psoriasis.

      What does this study add?

      • This study further demonstrates that brodalumab therapy in patients with moderate-to-severe plaque psoriasis results in a high degree of complete skin clearance.
      • This study also further elucidates the safety profile of brodalumab.
  8. Research letters

    1. Extending the spectrum of AKT1 mosaicism: not just the Proteus syndrome

      S. Polubothu, L. Al-Olabi, L. Wilson, W.K. Chong and V.A. Kinsler

      Version of Record online: 23 JUN 2016 | DOI: 10.1111/bjd.14478

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  9. Letters to the Editor

  10. Translational Research

    1. Epidermal filaggrin deficiency mediates increased systemic T-helper 17 immune response

      C.M. Bonefeld, T.H. Petersen, J. Bandier, C. Agerbeck, A. Linneberg, K. Ross-Hansen, S. Stender, P.B. Szecsi, J.D. Johansen, C. Geisler and J.P. Thyssen

      Version of Record online: 23 JUN 2016 | DOI: 10.1111/bjd.14570

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      What's already known about this topic?

      • An increased level of T-helper (Th)17 cells is found in the skin of flaky tail mice.
      • Th17 cells seem to be involved in the pathogenesis of atopic dermatitis.

      What does this study add?

      • We show that loss-of-function mutations in the filaggrin gene could be a driver of increased frequency of peripheral Th17 cells in both humans and mice.
      • The increase in Th17 cells is most likely mediated by extrinsic factors.

      What is the translational message?

      • Atopic dermatitis owing to filaggrin deficiency appears to have a Th17 profile.
      • Future experiments may examine whether anti-interleukin-17 medicaments may reduce disease severity.
  11. Research Letters

  12. General Dermatology

    1. Preoperative prediction of histopathological outcome in basal cell carcinoma: flat surface and multiple small erosions predict superficial basal cell carcinoma in lighter skin types

      I. Ahnlide, I. Zalaudek, F. Nilsson, M. Bjellerup and K. Nielsen

      Version of Record online: 23 JUN 2016 | DOI: 10.1111/bjd.14499

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      What's already known about this topic?

      • Superficial basal cell carcinomas (sBCCs) can be treated nonsurgically, but a correct diagnosis is crucial.
      • sBCCs exhibit certain macroscopic and dermoscopic characteristics.
      • Few studies have evaluated the accuracy of preoperative prediction of subtype of BCC in a routine clinical setting.

      What does this study add?

      • Mandatory use of dermoscopy improves the preoperative prediction of sBCC.
      • A flat surface and multiple small erosions are the best predictors for sBCC in lighter skin types.
  13. Systematic Reviews

    1. Interventions for hirsutism excluding laser and photoepilation therapy alone: abridged Cochrane systematic review including GRADE assessments

      E.J. van Zuuren and Z. Fedorowicz

      Version of Record online: 23 JUN 2016 | DOI: 10.1111/bjd.14486

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      What's already known about this topic?

      • Hirsutism is a common disorder with a major impact on quality of life.
      • Polycystic ovary syndrome is the most frequent cause of hirsutism.
      • It is unclear which treatments are safe and which are the most effective.

      What does this study add?

      • There is evidence that oral contraceptives, flutamide 250 mg twice daily and spironolactone 100 mg daily are effective and safe.
      • There was inconsistency of results for the effectiveness of finasteride and gonadotropin-releasing analogues.
      • Metformin appeared to be ineffective for the treatment of hirsutism.
  14. Book Reviews

  15. Letters to the Editor

  16. Medical Dermatology

    1. Both low circulating insulin-like growth factor-1 and high-density lipoprotein cholesterol are associated with hair loss in middle-aged women

      R. Noordam, D.A. Gunn, K. van Drielen, G. Westgate, P.E. Slagboom, A.J.M. de Craen and D. van Heemst

      Version of Record online: 23 JUN 2016 | DOI: 10.1111/bjd.14529

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      What's already known about this topic?

      • Multiple biomarkers have been associated with female hair loss, but studies have shown inconsistent results.

      What does this study add?

      • We identified low high-density lipoprotein cholesterol and low insulin-like growth factor-1 as independent risk factors for female hair loss.
      • When the data are replicated, pathways leading to female hair loss can be identified as potential treatment targets.
  17. Case Reports

    1. Segmental basal cell naevus syndrome caused by an activating mutation in smoothened

      Z. Khamaysi, R. Bochner, M. Indelman, L. Magal, E. Avitan-Hersh, O. Sarig, E. Sprecher and R. Bergman

      Version of Record online: 20 JUN 2016 | DOI: 10.1111/bjd.14425

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      What's already known about this topic?

      • Mutations in smoothened (SMO) have been previously reported in acquired basal cell carcinomas but not in basal cell naevus syndrome (BCNS).

      What does this study add?

      • A gain-of-function mutation in SMO was demonstrated in the type 1 mosaic form of BCNS, which further expands the understanding of this syndrome.
  18. Epidemiology

    1. Association between psoriasis and inflammatory bowel disease: a Danish nationwide cohort study

      A. Egeberg, L. Mallbris, R.B. Warren, H. Bachelez, G.H. Gislason, P.R. Hansen and L. Skov

      Version of Record online: 20 JUN 2016 | DOI: 10.1111/bjd.14528

      What's already known about this topic?

      • Co-occurrence of psoriasis and inflammatory bowel disease (IBD) has been described, but data are inconsistent.

      What does this study add?

      • In a nationwide cohort study, we found a bidirectional relationship between psoriasis and IBD.
  19. Letters to the Editor

    1. Epstein–Barr virus-associated B-cell lymphoproliferative disorder in a patient with Sézary syndrome treated by methotrexate

      S. Ingen-Housz-Oro, N. Ortonne, N. Cordel, J. Moroch, G. Do-Pham, M.H. Delfau, C. Haioun and O. Chosidow

      Version of Record online: 20 JUN 2016 | DOI: 10.1111/bjd.14602

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  20. Research Letters

  21. Research letters

  22. Case Reports

    1. Worsening of calcinosis cutis with teriparatide treatment in two osteoporotic patients

      A.F. Echeverri, F.E. Ospina, C.A. Cañas, A. Agualimpia, J.P. Suso, G.J. Tobón and F. Bonilla-Abadía

      Version of Record online: 20 JUN 2016 | DOI: 10.1111/bjd.14550

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      What's already known about this topic?

      • After searching the literature with the medical subject heading terms ‘calcinosis cutis’, ‘teriparatide’ and ‘complications’, we found no known literature on this topic.

      What does this study add?

      • We report two cases of systemic autoimmune disease with concomitant calcinosis cutis that worsened on treatment with teriparatide.
      • We alert practitioners to the possible side-effects of teriparatide in patients with dermatomyositis and CREST syndrome who have calcinosis cutis.
  23. Research Letters

    1. The new Cutaneous Lymphoma International Prognostic index (CLIPi) for early mycosis fungoides failed to identify prognostic groups in a cohort of Spanish patients

      J. Sanz-Bueno, D. Lora, V. Monsálvez, L. Maroñas-Jiménez, C. Postigo, J.L. Rodríguez- Peralto and P.L. Ortiz-Romero

      Version of Record online: 20 JUN 2016 | DOI: 10.1111/bjd.14559

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    2. Increased airway inflammation in patients with psoriasis

      G. Damiani, A. Radaeli, A. Olivini, P. Calvara-Pinton and M. Malerba

      Version of Record online: 20 JUN 2016 | DOI: 10.1111/bjd.14546

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  24. Letters to the Editor

    1. Discrepant mutational status between naevi and melanomas in naevus-associated melanomas: about mutation-specific immunohistochemistry: reply from the authors

      D. Shitara, G. Tell-Martí, C. Badenas, M.M.S.S. Enokihara, L. Alós, A.B. Larque, N. Michalany, J.A. Puig-Butille, C. Carrera, J. Malvehy, S. Puig and E. Bagatin

      Version of Record online: 16 JUN 2016 | DOI: 10.1111/bjd.14613

  25. Case Reports

    1. Endothelial chimerism in chronic sclerotic-type chronic graft-versus-host disease (GVHD) and GVHD-associated angiomatosis

      B.H. Kaffenberger, E. Zhang, J.R. Duncan, S. Jaglowski, R.B. Klisovic, S.M. Devine, H.K. Wong and A.A. Gru

      Version of Record online: 10 JUN 2016 | DOI: 10.1111/bjd.14484

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      What's already known about this topic?

      • Graft-versus-host disease-associated angiomatosis (GVHD-AA) is a recently described uncommon presentation of endothelial proliferation developing exclusively within areas of sclerotic-type GVHD, resulting in friable capillary proliferations.
      • Transplanted human bone marrow has recently been shown to contribute to normal vascular endothelium in female patients with sex-mismatched donors.

      What does this study add?

      • Based on two female patients with sex-mismatched donors, using fluorescence in situ hybridization we show that donor endothelial cells are present in GVHD-AA.
      • While endothelial chimerism has been previously documented following transplantation, this report documents for the first time the occurrence of a benign neoplastic growth in relationship to a form of chronic GVHD.
  26. Research Letters

    1. You have full text access to this OnlineOpen article
  27. Epidemiology

    1. Vitamin D levels and atopic eczema in infancy and early childhood in Norway: a cohort study

      T.L. Berents, K.C. Lødrup Carlsen, P. Mowinckel, L. Sandvik, H.O. Skjerven, L.B. Rolfsjord, B. Kvenshagen, J.O.G. Hunderi, M. Bradley, A. Lieden, K.-H. Carlsen, P.M. Thorsby and P. Gjersvik

      Version of Record online: 9 JUN 2016 | DOI: 10.1111/bjd.14537

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      What's already known about this topic?

      • Epidemiological and clinical data suggest that vitamin D (vitD) may be of importance in atopic eczema (AE).
      • Results from studies on the association between vitD levels and AE are conflicting.

      What does this study add?

      • In a cohort of young children living in Norway, vitD levels were not associated with AE.
  28. Case Reports

    1. CDKN2A mutations with p14 loss predisposing to multiple nerve sheath tumours, melanoma, dysplastic naevi and internal malignancies: a case series and review of the literature

      M.R. Sargen, S.L. Merrill, E.Y. Chu and K.L. Nathanson

      Version of Record online: 8 JUN 2016 | DOI: 10.1111/bjd.14485

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      What's already known about this topic?

      • CDKN2A mutations with p16 loss predispose to melanoma and pancreatic cancer.

      What does this study add?

      • This is the first report of a family with a splice-site mutation resulting in loss of p16INK4 and p14ARF to present with multiple nerve sheath tumours.
      • We provide cancer screening recommendations for patients with mutations in CDKN2A resulting in loss of both p14 and p16, which predispose patients to a variety of carcinomas, sarcomas and brain tumours.
  29. Letters to the Editor

  30. Case Reports

    1. Swamp cancer: a case of human pythiosis and review of the literature

      R.E. Hilton, K. Tepedino, C.J. Glenn and K.L. Merkel

      Version of Record online: 7 JUN 2016 | DOI: 10.1111/bjd.14520

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      What's already known about this topic?

      • Pythiosis is an endemic infectious disease in Thailand associated with high morbidity and mortality; however, it is rare in North America.
      • Very few cases of cutaneous disease have been reported in the literature.

      What does this study add?

      • We present a case of pythiosis in North America, and review the previously reported cases of cutaneous pythiosis.
      • Our case highlights the importance of increased awareness of this infectious disease in order to facilitate early recognition and treatment.
  31. Letters to the Editor

    1. Response to ‘Darier disease in Israel: combined evaluation of genetic and neuropsychiatric aspects’: reply from the authors

      R.P. Dodiuk-Gad, E. Cohen-Barak, M. Khayat, H. Milo, L. Amariglio-Diskin, N. Danial-Faran, M. Sah, M. Ziv, A. Shani-Adir, B. Amichai, A. Zlotogorski, Z. Borochowitz, D. Rozenman and S. Shalev

      Version of Record online: 7 JUN 2016 | DOI: 10.1111/bjd.14544

  32. Research Letters

    1. Comparing the effect of bleach and water baths on skin barrier function in atopic dermatitis: a split-body randomized controlled trial

      V.Y. Shi, N. Foolad, J.N. Ornelas, L.A. Hassoun, G. Monico, N. Takeda, S. Saric, N. Prakash, L.F. Eichenfield and R.K. Sivamani

      Version of Record online: 7 JUN 2016 | DOI: 10.1111/bjd.14483

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  33. Research letters

  34. Clinical Trials

    1. Phase II multicentre trial of oral quisinostat, a histone deacetylase inhibitor, in patients with previously treated stage IB–IVA mycosis fungoides/Sézary syndrome

      F. Child, P.L. Ortiz-Romero, R. Alvarez, M. Bagot, R. Stadler, M. Weichenthal, R. Alves, P. Quaglino, M. Beylot-Barry, R. Cowan, L.J. Geskin, A. Pérez-Ferriols, P. Hellemans, Y. Elsayed, C. Phelps, A. Forslund, M. Kamida and P.L. Zinzani

      Version of Record online: 2 JUN 2016 | DOI: 10.1111/bjd.14427

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      What's already known about this topic?

      • Histone deacetylase inhibitors (HDAC-Is) have been associated with significant clinical activity in different neoplastic disorders. Vorinostat and romidepsin have been approved by the U.S. Food and Drug Administration for treatment of cutaneous T-cell lymphoma (CTCL).
      • Quisinostat is a hydroxamate, second-generation, orally available pan-HDAC-I.

      What does this study add?

      • Oral quisinostat 12 mg three times weekly is active in the treatment of patients with relapsed or refractory CTCL, and has an acceptable safety profile.
      • There was a low global response rate of 8% vs. a cutaneous response rate of 24%.
      • Combination therapy of quisinostat with other novel agents may be appropriate in patients who relapse following current conventional approaches.
  35. Research Letters

  36. General Dermatology

    1. In vivo confocal microscopy efficacy assessment of daylight photodynamic therapy in actinic keratosis patients

      S.M. Seyed Jafari, T. Timchik and R.E. Hunger

      Version of Record online: 30 MAY 2016 | DOI: 10.1111/bjd.14517

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      What's already known about this topic?

      • Actinic keratosis (AK) is the most common precancerous cutaneous lesion.
      • Reflectance confocal microscopy (RCM) is a noninvasive diagnostic technique with an acceptable sensitivity and specificity for AK.

      What does this study add?

      • In vivo RCM technology might be an additional technique to monitor the efficacy of daylight photodynamic therapy for AK.
      • The atypia scoring system is an applicable technique to facilitate the use of RCM technology as an additional monitoring method.
  37. Translational Research

    1. Microarray study reveals a transforming growth factor-β-dependent mechanism of fibrosis in discoid lupus erythematosus

      C. Solé, M. Gimenez-Barcons, B. Ferrer, J. Ordi-Ros and J. Cortés-Hernández

      Version of Record online: 29 MAY 2016 | DOI: 10.1111/bjd.14539

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      What's already known about this topic?

      • Discoid lupus erythematosus (DLE) lesions lead to fibrotic changes, whereas subacute cutaneous lupus erythematosus (SCLE) lesions do not.
      • The mechanism of fibrosis formation is currently unknown.

      What does this study add?

      • The first microarray study between the two types of lupus, showing a significantly high-intensity T-regulatory-cell response in DLE that is sustained over time.
      • Discoid cutaneous lupus lesions express a hyperactivated transforming growth factor-β pathway that contributes to the development of fibrosis.

      What is the translational message?

      • This study provides the first proposed mechanism for the formation and perpetuation of fibrosis in DLE lesions based on the differential molecular patterns found between DLE and SCLE skin biopsies.
      • The results provided allow a better understanding of the pathogenesis of DLE skin lesions and open a new field for the research and development of specific treatments.
  38. Research Letters

    1. Ketoconazole does not decrease fungal amount in patients with seborrhoeic dermatitis

      M.B. Zani, R.C. Soares, A.C.B.B. Arruda, L.H.F. de Arruda and L.C. Paulino

      Version of Record online: 29 MAY 2016 | DOI: 10.1111/bjd.14501

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  39. Medical Dermatology

    1. Diagnostic patch testing following tuberculosis-associated cutaneous adverse drug reactions induces systemic reactions in HIV-infected persons

      R.J. Lehloenya, G. Todd, J. Wallace, M.R. Ngwanya, R. Muloiwa and K. Dheda

      Version of Record online: 26 MAY 2016 | DOI: 10.1111/bjd.14492

      What's already known about this topic?

      • HIV-infected persons are predisposed to frequent and severe cutaneous adverse drug reactions (CADRs).
      • The utility of patch testing in the diagnosis of CADR varies with the type of CADR and the offending drug.
      • Patch testing is not well defined for tuberculosis-associated CADR in HIV-infected persons.

      What does this study add?

      • In HIV-infected persons with tuberculosis-associated CADR, patch testing reactions to first-line antituberculosis drugs seem to be associated with systemic features, not localized reactions.
  40. Research Letters

    1. Is a punch biopsy reliable in subtyping basal cell carcinoma? A systematic review

      D.J. Kadouch, A. van Haersma de With, J. Limpens, A.C. van der Wal, A. Wolkerstorfer, M.W. Bekkenk and M.A. de Rie

      Version of Record online: 26 MAY 2016 | DOI: 10.1111/bjd.14458

  41. Epidemiology

    1. Predictive factors of self-reported hand eczema in adult Danes: a population-based cohort study with 5-year follow-up

      N.G. Heede, J.P. Thyssen, B.H. Thuesen, A. Linneberg and J.D. Johansen

      Version of Record online: 24 MAY 2016 | DOI: 10.1111/bjd.14476

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      What's already known about this topic?

      • Atopic dermatitis (AD), female sex, contact sensitization and wet work are known risk factors for hand eczema.
      • Knowledge about predictive factors of hand eczema in the adult general population is limited.

      What does this study add?

      • A history of AD predicts both incident and persistent hand eczema in adults.
      • Filaggrin gene (FLG) null mutations strongly predict persistent hand eczema, but the association with incident hand eczema in adults is nonsignificant.
      • Contact sensitization is significantly associated with persistent hand eczema, also in participants without AD.
  42. Letters to the Editor

  43. Research Letters

    1. Trichoscopy as an additional tool for the differential diagnosis of tinea capitis: a prospective clinical study

      A. Brasileiro, S. Campos, J. Cabete, C. Galhardas, A. Lencastre and V. Serrão

      Version of Record online: 23 MAY 2016 | DOI: 10.1111/bjd.14413

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  44. Research letters

    1. Risk of bias does not differ between full papers and letters reporting dermatological randomized controlled trials

      D.N. Chauhan, S.R. Wilkes, S. Ratib, E. Doney, J.M. Batchelor, N.K. Rogers and H.C. Williams

      Version of Record online: 22 MAY 2016 | DOI: 10.1111/bjd.14455

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  45. Research Letters

    1. Parkinson disease and multiple sclerosis are not associated with autoantibodies against structural proteins of the dermal–epidermal junction

      A. Recke, A. Oei, F. Hübner, K. Fechner, J. Graf, J. Hagenah, C. May, D. Woitalla, A. Salmen, D. Zillikens, R. Gold, W. Schlumberger and E. Schmidt

      Version of Record online: 18 MAY 2016 | DOI: 10.1111/bjd.14538

  46. Letters to the Editor

    1. Bier anaemic spots, cyanosis with urticaria-like eruption (BASCULE) syndrome: a new entity?

      D. Bessis, É. Jeziorski, V. Rigau, P. Pralong and V. Pallure

      Version of Record online: 18 MAY 2016 | DOI: 10.1111/bjd.14589

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  47. Translational Research

    1. Zinc finger protein A20 is involved in the antipsoriatic effect of calcipotriol

      X. Liu, Y. Liu, M. Xu, J. Li, X. Teng, H. Cheng and Y. Xia

      Version of Record online: 14 MAY 2016 | DOI: 10.1111/bjd.14481

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      What's already known about this topic?

      • TNFAIP3 (encoding A20) polymorphisms are associated with the susceptibility to psoriasis.
      • A20 exhibits an anti-apoptotic effect on various types of cells, and regulates nuclear factor kappa B (NF-κB) activation.
      • Calcipotriol ameliorates psoriasis through inducing apoptosis of keratinocytes.

      What does this study add?

      • A20 expression increases in keratinocytes under psoriatic inflammation.
      • Calcipotriol suppresses A20 expression in psoriatic tissues or keratinocytes.
      • Under psoriatic inflammation, NF-κB inhibition occurs in keratinocytes with A20 downregulation induced by calcipotriol.
      • Calcipotriol promotes the binding of A20 to ring finger protein 114 (RNF114) and A20-binding inhibitor of NF-κB-1 (ABIN-1) partners, which are known to downregulate the NF-κB pathway.

      What is the translational message?

      • The A20 pathway may be a therapeutic target for treating psoriasis.
  48. Research letters

  49. General Dermatology

    1. You have full text access to this OnlineOpen article
      Psychometric properties of the Itch Numeric Rating Scale in patients with moderate-to-severe plaque psoriasis

      A.B. Kimball, A.N. Naegeli, E. Edson-Heredia, C.-Y. Lin, C. Gaich, E. Nikaï, K. Wyrwich and G. Yosipovitch

      Version of Record online: 8 MAY 2016 | DOI: 10.1111/bjd.14464

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      What's already known about this topic?

      • Itching is a profoundly distressing symptom for many patients with psoriasis, but has not been rigorously studied using validated tools for this condition.
      • The Itch Numeric Rating Scale is a single-item instrument that assesses the severity of itch due to psoriasis.

      What does this study add?

      • The Itch Numeric Rating Scale demonstrated sufficient reliability, validity and responsiveness, and appropriate interpretation standards for evaluating change over time in itch severity among patients with moderate-to-severe plaque psoriasis.
  50. Review Articles

    1. You have full text access to this OnlineOpen article
      Development of core outcome sets in hidradenitis suppurativa: systematic review of outcome measure instruments to inform the process

      J.R. Ingram, S. Hadjieconomou and V. Piguet

      Version of Record online: 2 MAY 2016 | DOI: 10.1111/bjd.14475

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      What's already known about this topic?

      • The recent hidradenitis suppurativa (HS) Cochrane review identified heterogeneity of outcome measure instruments as an important obstacle in the design of future HS trials.
      • The Harmonising Outcome Measures for Eczema (HOME) initiative provides a roadmap for developing a core outcomes set in HS.

      What does this study add?

      • Twenty-seven of the 30 outcome measure instruments used in HS randomized controlled trials are not supported by any formal validation data.
      • Where available, validation evidence is generally of relatively low methodological quality, or remains incomplete, and so no instruments can be fully recommended currently.
  51. General Dermatology

    1. N-Acyl ethanolamide and eicosanoid involvement in irritant dermatitis

      A.C. Kendall, S.M. Pilkington, G. Sassano, L.E. Rhodes and A. Nicolaou

      Version of Record online: 28 APR 2016 | DOI: 10.1111/bjd.14521

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      What's already known about this topic?

      • Bioactive lipid mediators are emerging as important players in cutaneous homeostasis and inflammation.
      • Irritant dermatitis is a considerable problem in dermatology/occupational health, and would benefit from greater understanding of the role of lipids in the skin's response to irritants.

      What does this study add?

      • Specific eicosanoid and endocannabinoid mediators contribute to the inflammatory response to the common irritant sodium lauryl sulfate but not to ultraviolet radiation challenge matched to generate comparable erythema.
      • Our findings provide insights into pathways involved in irritant dermatitis, with potential translation to novel treatments and new means for assessing contact irritants.
  52. Translational Research

    1. Serum and salivary IgG and IgA antibodies to desmoglein 3 in mucosal pemphigus vulgaris

      S. Ali, C. Kelly, S.J. Challacombe, A.N.A. Donaldson, B.S. Bhogal and J.F. Setterfield

      Version of Record online: 27 APR 2016 | DOI: 10.1111/bjd.14410

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      What's already known about this topic?

      • The use of serum to test for IgG autoantibodies to desmoglein (Dsg)3 by enzyme-linked immunosorbent assay has been well documented.
      • Salivary IgG anti-Dsg3 antibodies have been previously detected in three studies in pemphigus vulgaris (PV) and have been proposed as a diagnostic marker.

      What does this study add?

      • This study demonstrates that detection of salivary antibodies provides a practical alternative to serum in the diagnosis of PV. Salivary antibodies may also be used for the monitoring of disease activity in patients with PV.
      • Both IgG and IgA serum antibodies to Dsg3 are detected in IgG-driven PV. Further investigation is needed to understand the role of IgA in the pathogenesis of PV.

      What is the translational message?

      • The simplicity of obtaining a whole saliva sample and the demonstration that anti-Dsg3 IgG antibodies can be easily detected suggests that saliva may become a useful diagnostic screening test for PV.
      • As titres are related to disease activity, repeated noninvasive sampling offers the possibility of routine remote monitoring of disease.
    2. Common and rare CARD14 gene variants affect the antitumour necrosis factor response among patients with psoriasis

      P. Coto-Segura, D. González-Fernández, A. Batalla, J. Gómez, L. González-Lara, R. Queiro, B. Alonso, S. Iglesias and E. Coto

      Version of Record online: 25 APR 2016 | DOI: 10.1111/bjd.14461

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      What's already known about this topic?

      • Patients with psoriasis treated with antitumour necrosis factor (anti-TNF) agents (and other biological therapies) exhibit a heterogeneous response.
      • This could be explained partly by the variability in genes that encode components of immunological pathways.
      • Rare and common CARD14 variants have been linked to the risk for psoriasis, but no study about the effect on anti-TNF response has been reported.

      What does this study add?

      • Our study showed that the CARD14 rs11652075 polymorphism (Arg820Trp) was associated with the response to anti-TNF agents among patients with psoriasis.
      • The genotype that increased the risk for psoriasis was also a significant predictor of a better anti-TNF response, measured as ≥ 75% improvement in Psoriasis Area and Severity Index at week 24.

      What is the translational message?

      • Variants of the CARD14 gene (a regulator of nuclear factor-κB-mediated pathways) have been associated with the overall risk of developing psoriasis in case–control studies.
      • In this work, we show that CARD14 variants are also related to the response to anti-TNF agents.
      • If the results are confirmed by others, the analysis of this gene might help dermatologists to optimize treatment with anti-TNF biological drugs.
  53. Research Letters

    1. PSTPIP1 gene mutation in a pyoderma gangrenosum, acne and suppurative hidradenitis (PASH) syndrome

      X. Calderón-Castrat, D. Bancalari-Díaz, C. Román-Curto, A. Romo-Melgar, D. Amorós-Cerdán, L.A. Alcaraz-Mas, E. Fernández-López and J. Cañueto

      Version of Record online: 19 APR 2016 | DOI: 10.1111/bjd.14383

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  54. Letters to the Editor

  55. Translational Research

    1. IgE and FcεRI are highly expressed on innate cells in psoriasis

      K-X. Yan, Q. Huang, X. Fang, Z-H. Zhang, L. Han, K. Gadaldi, K-F. Kang, Z-Z. Zheng, J-H. Xu and N. Yawalkar

      Version of Record online: 18 APR 2016 | DOI: 10.1111/bjd.14459

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      What's already known about this topic?

      • Serum total IgE levels are elevated in patients with psoriasis.

      What does this study add?

      • The expression of IgE and FcεRI was particularly enhanced on innate cells in psoriatic lesions. The numbers of IgE+ and FcεRI+ cells in psoriatic lesions significantly decreased after treatment with ustekinumab.

      What is the translational message?

      • IgE-mediated mechanisms may perpetuate cutaneous inflammation in a subset of patients with psoriasis.
  56. Letters to the Editor

    1. Short-contact, low-dose methyl aminolaevulinate photodynamic therapy for acne vulgaris

      C. Dessinioti, S. Masouri, E. Drakaki, A. Katsambas and C. Antoniou

      Version of Record online: 18 APR 2016 | DOI: 10.1111/bjd.14460

  57. Research Letters

    1. Net-like superficial vascular malformation: clinical description and evidence for lymphatic origin

      L. Noguera-Morel, S.L. Stein, G. Xirotagaros, A. Hernández-Martín, I. de Prada, I.J. Frieden, L. Requena and A. Torrelo

      Version of Record online: 18 APR 2016 | DOI: 10.1111/bjd.14404

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  58. General Dermatology

    1. Multicentre study on inflammatory skin diseases from The International Confocal Working Group: specific confocal microscopy features and an algorithmic method of diagnosis

      M. Ardigo, C. Longo, S. Gonzalez and The International Confocal Working Group Inflammatory Skin Diseases Project

      Version of Record online: 18 APR 2016 | DOI: 10.1111/bjd.14516

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      What's already known about this topic?

      • Reflectance confocal microscopy has been used successfully for the evaluation of several inflammatory skin diseases.

      What does this study add?

      • Reflectance confocal microscopy provides features useful for diagnosis and differential diagnosis of the major inflammatory skin diseases.
      • An algorithmic method originating from multivariate analysis can be used for the diagnosis.
  59. Research letters

    1. Drug survival for azathioprine and enteric-coated mycophenolate sodium in a long-term daily practice cohort of adult patients with atopic dermatitis

      J. van der Schaft, K. Politiek, J.M.P.A. van den Reek, W. Kievit, E.M.G.J. de Jong, C.A.F.M. Bruijnzeel-Koomen, M.L.A. Schuttelaar and M.S. de Bruin-Weller

      Version of Record online: 17 APR 2016 | DOI: 10.1111/bjd.14398

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  60. Case Reports

    1. Topical sodium metabisulfite for the treatment of calcinosis cutis: a promising new therapy

      P. del Barrio-Díaz, C. Moll-Manzur, S. Álvarez-Veliz and C. Vera-Kellet

      Version of Record online: 17 APR 2016 | DOI: 10.1111/bjd.14412

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      What's already known about this topic?

      • Calcinosis cutis is a chronic calcium-mediated disease that causes significant morbidity for patients.
      • Multiple treatments have been tried, many of them with varying results and side-effects. To date, no standard treatment has been generally accepted.

      What does this study add?

      • Topical sodium metabisulfite is a new, inexpensive emerging therapy that should be considered as a valid alternative treatment in patients with calcinosis cutis, especially in countries where topical sodium thiosulfate is not available.
    2. Two cases of overlap severe cutaneous adverse reactions to benznidazole treatment for asymptomatic Chagas disease in a nonendemic country

      J. González-Ramos, L. Noguera-Morel, H.Y. Tong, E. Ramírez, E. Ruiz-Bravo, T. Bellón, R. Cabañas, L. Cachafeiro and P. Herranz-Pinto

      Version of Record online: 7 APR 2016 | DOI: 10.1111/bjd.14451

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      What's already known about this topic?

      • Cutaneous reactions to benznidazole are common; however, severe cases have rarely been reported.

      What does this study add?

      • Benznidazole may induce potentially life-threatening severe cutaneous adverse reactions.
      • There should be greater awareness among physicians of this newly reported risk.
  61. Medical Dermatology

    1. Calculation of cut-off values based on the Autoimmune Bullous Skin Disorder Intensity Score (ABSIS) and Pemphigus Disease Area Index (PDAI) pemphigus scoring systems for defining moderate, significant and extensive types of pemphigus

      C. Boulard, S. Duvert Lehembre, C. Picard-Dahan, J.S. Kern, G. Zambruno, C. Feliciani, B. Marinovic, P. Vabres, L. Borradori, C. Prost-Squarcioni, B. Labeille, M.A. Richard, S. Ingen-Housz-Oro, E. Houivet, V.P. Werth, D.F. Murrell, M. Hertl, J. Benichou, P. Joly and on behalf of the International Pemphigus Study Group

      Version of Record online: 3 APR 2016 | DOI: 10.1111/bjd.14405

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      What's already known about this topic?

      • The Autoimmune Bullous Skin Disorder Intensity Score (ABSIS) and Pemphigus Disease Area Index (PDAI) are new scoring systems to measure pemphigus activity.
      • The use of these scores in clinical practice is limited by the absence of cut-off values.

      What does this study add?

      • Cut-off values distinguishing moderate, significant and extensive pemphigus were 15 and 45 for PDAI, and 17 and 53 for ABSIS.
      • These disease activity subgroups should help physicians in the management of patients with pemphigus.
  62. Research Letters

  63. Case Reports

    1. [18F]-Fluorodeoxy-d-glucose uptake-positive seborrhoeic keratosis on positron emission tomography may result from high expression of glucose transporter

      T. Kariya, Y. Kato, A. Kanzaki, Y. Kanda, T. Ohara and R. Tsuboi

      Version of Record online: 20 MAR 2016 | DOI: 10.1111/bjd.14421

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      What's already known about this topic?

      • [18F]-Fluorodeoxy-d-glucose (FDG) positron emission tomography–computed tomography (PET-CT) is known to be highly accurate in differentiating benign lesions from malignant lesions.
      • In rare cases, benign tumours, viral infections and sarcoidosis of the skin have been reported to show FDG uptake, but the mechanism remains unclear.

      What does this study add?

      • We report, for the first time, a case of seborrhoeic keratosis (SK) with increased FDG uptake.
      • The expression of glucose transporter (GLUT)1 and GLUT3 was higher in PET- positive SK than in PET-negative SK or in normal skin.
      • High expression of GLUT1 and GLUT3 in benign tumours like SK, as in this case, might be associated with the uptake of FDG.
  64. Research Letters

    1. Bullous pemphigoid suggestive of complement-independent blister formation with anti-BP180 IgG4 autoantibodies

      T. Dainichi, W. Nishie, Y. Yamagami, H. Sonobe, H. Ujiie, Y. Kaku and K. Kabashima

      Version of Record online: 18 MAR 2016 | DOI: 10.1111/bjd.14411

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  65. Case Reports

    1. Extensive tumoral melanosis associated with ipilimumab-treated melanoma

      K. Staser, D. Chen, J. Solus, I.S. Rosman, A. Schaffer, L. Cornelius, G.P. Linette and R.C. Fields

      Version of Record online: 18 MAR 2016 | DOI: 10.1111/bjd.14474

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      What's already known about this topic?

      • Limited tumoral melanosis occurs in the context of regressed melanoma.
      • Ipilimumab activates the immune system and promotes tumour killing.

      What does this study add?

      • This study shows tumoral melanosis to an extent previously not described.
      • This extensive melanosis occurred in the context of ipilimumab treatment, suggesting that activated immunity may result in aggressive melanophagocytosis.
  66. Translational Research

    1. Infiltration of M2-polarized macrophages in infected lymphatic malformations: possible role in disease progression

      W. Zhang, K.-F. He, J.-G. Yang, J.-G. Ren, Y.-F. Sun, J.-H. Zhao and Y.-F. Zhao

      Version of Record online: 15 MAR 2016 | DOI: 10.1111/bjd.14471

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      What's already known about this topic?

      • Infection in lymphatic malformations (LMs) promotes the development of the disease.
      • Tertiary lymphoid organs (TLOs) are found in most LMs.
      • Macrophages intensively promote lymphangiogenesis in pathological conditions.

      What does this study add?

      • M2-polarized macrophages are increased in LMs compared with skin tissues.
      • A close relationship between M2-polarized macrophages and TLOs was uncovered in LMs.
      • M2-polarized macrophages and TLOs might contribute to the progression of LMs after infection.

      What is the translational message?

      • Infection or inflammation in LMs indicated poor prognosis of the disease.
      • Targeting M2-polarized macrophages might be a promising therapy for LMs.
      • Targeting TLO formation might alleviate the progression of LMs by reducing macrophage recruitment and lymphatic vessel formation.
  67. Epidemiology

    1. Atopic dermatitis is not associated with actinic keratosis: cross-sectional results from the Rotterdam study

      E. Hajdarbegovic, H. Blom, J.A.C. Verkouteren, A. Hofman, L.M. Hollestein and T. Nijsten

      Version of Record online: 14 MAR 2016 | DOI: 10.1111/bjd.14423

      What's already known about this topic?

      • Patients with severe atopic dermatitis (AD) treated with ultraviolet therapy and immunosuppressants are at an increased risk of keratinocyte malignancies.

      What does this study add?

      • Community-dwelling, average patients with AD do not have more actinic keratoses or keratinocyte cancers than those without AD.
      • There is no support for extra actinic keratosis and keratinocyte cancer screening in patients with mild-to-moderate AD.
  68. Research Letters

    1. Skin and soft tissue infections and acute kidney injury: a systematic review

      S.R. Wilkes, E. Burden-Teh, F. Robertson, D. Grindlay and N.M. Selby

      Version of Record online: 3 MAR 2016 | DOI: 10.1111/bjd.14368

  69. General Dermatology

    1. Airborne formaldehyde causes skin barrier dysfunction in atopic dermatitis

      J. Kim, Y. Han, J.H. Ahn, S.W. Kim, S.I. Lee, K.H. Lee and K. Ahn

      Version of Record online: 28 FEB 2016 | DOI: 10.1111/bjd.14357

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      What's already known about this topic?

      • For the proper management of atopic dermatitis (AD), aggravating factors in the environment must be identified and controlled.
      • For example, foods, inhalant allergens, and microorganisms such as bacteria and viruses are well-known factors that can exacerbate AD symptoms.
      • Epidemiological studies have implicated air pollutants and their associated hazardous effects in AD, but these studies have not provided direct evidence for causality.

      What does this study add?

      • We used a provocation test device that we developed for topical stimulation of the skin in children, and found that airborne formaldehyde increases transepidermal water loss and skin pH in healthy children and more prominently in patients with AD.
      • We revealed the causal relationship between airborne formaldehyde and skin barrier dysfunction in children with AD.
      • Exposure to airborne formaldehyde must be avoided to prevent aggravation of AD.
  70. Review Articles

    1. Cutaneous manifestations of Helicobacter cinaedi: a review

      S. Shimizu and H. Shimizu

      Version of Record online: 18 FEB 2016 | DOI: 10.1111/bjd.14353

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      What's already known about this topic?

      • Helicobacter cinaedi causes bacteraemia and cellulitis in immunodeficient individuals; however, details of the cutaneous manifestations and their management are not fully described.

      What does this study add?

      • The cutaneous manifestations, epidemiology and management of H. cinaedi infection are described in detail. Helicobacter cinaedi cellulitis, which appears as multiple painful infiltrated erythemas on the extremities, is the most common cutaneous symptom of H. cinaedi bacteraemia.
  71. Scholarly Reviews

    1. Pyoderma gangrenosum and Sweet syndrome: the prototypic neutrophilic dermatoses

      D. Wallach and M.-D. Vignon-Pennamen

      Version of Record online: 22 JUL 2015 | DOI: 10.1111/bjd.13955

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      What's already known about this topic?

      • Pyoderma gangrenosum and Sweet syndrome are the prototypic conditions of the vast group of the neutrophilic dermatoses, characterized by an aseptic infiltration of the skin by polymorphonuclear leucocytes.
      • A similar infiltration may also occur in internal organs, defining the neutrophilic disease.
      • The principles of the management of patients with a neutrophilic disease have been properly described.

      What does this study add?

      • The genetic and molecular mechanisms of neutrophilic inflammation are currently poorly understood.
      • They may be similar to the mechanisms of the monogenic autoinflammatory diseases, which are among the rare causes of neutrophilic dermatoses.

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