British Journal of Dermatology

Cover image for Vol. 174 Issue 4

Early View (Online Version of Record published before inclusion in an issue)

Editor: Alex Anstey, Bangor, UK

Impact Factor: 4.275

ISI Journal Citation Reports © Ranking: 2014: 6/63 (Dermatology)

Online ISSN: 1365-2133

Associated Title(s): Clinical and Experimental Dermatology

VIEW

  1. 1 - 94
  1. Letters to the Editor

    1. Unilateral hyperhidrosis and hypothermia: symptoms of an intrathoracic tumour

      B. Dyring-Andersen, S. Kamp, A. Madelung and C. Zachariae

      Article first published online: 4 MAY 2016 | DOI: 10.1111/bjd.14257

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  2. Research Letters

  3. Translational Research

    1. Increased expression of CXCR3 and its ligands in patients with vitiligo and CXCL10 as a potential clinical marker for vitiligo

      X. X. Wang, Q. Q. Wang, J. Q. Wu, M. Jiang, L. Chen, C. F. Zhang and L. H. Xiang

      Article first published online: 4 MAY 2016 | DOI: 10.1111/bjd.14416

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      What's already known about this topic?

      • A T-cell-mediated immune response is responsible for melanocyte destruction in vitiligo.
      • CXCL10 is critical for the progression and maintenance of depigmentation in a mouse model of vitiligo.

      What does this study add?

      • CXCL9 and CXCL10, in parallel with their receptor, CXCR3, are present in patients with vitiligo and correlate with disease activity and severity.
      • Serum CXCL10 may be a novel biomarker in monitoring disease activity and guiding treatment of progressive vitiligo.

      What is the translational message?

      • Blocking the CXCL10/CXCR3 chemotactic mechanism may present a new form of therapy for progressive vitiligo.
  4. Review Articles

    1. You have full text access to this OnlineOpen article
      Development of core outcome sets in hidradenitis suppurativa: systematic review of outcome measure instruments to inform the process

      J.R. Ingram, S. Hadjieconomou and V. Piguet

      Article first published online: 2 MAY 2016 | DOI: 10.1111/bjd.14475

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      What's already known about this topic?

      • The recent hidradenitis suppurativa (HS) Cochrane review identified heterogeneity of outcome measure instruments as an important obstacle in the design of future HS trials.
      • The Harmonising Outcome Measures for Eczema (HOME) initiative provides a roadmap for developing a core outcomes set in HS.

      What does this study add?

      • Twenty-seven of the 30 outcome measure instruments used in HS randomized controlled trials are not supported by any formal validation data.
      • Where available, validation evidence is generally of relatively low methodological quality, or remains incomplete, and so no instruments can be fully recommended currently.
  5. General Dermatology

    1. N-Acyl ethanolamide and eicosanoid involvement in irritant dermatitis

      A.C. Kendall, S.M. Pilkington, G. Sassano, L.E. Rhodes and A. Nicolaou

      Article first published online: 28 APR 2016 | DOI: 10.1111/bjd.14521

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      What's already known about this topic?

      • Bioactive lipid mediators are emerging as important players in cutaneous homeostasis and inflammation.
      • Irritant dermatitis is a considerable problem in dermatology/occupational health, and would benefit from greater understanding of the role of lipids in the skin's response to irritants.

      What does this study add?

      • Specific eicosanoid and endocannabinoid mediators contribute to the inflammatory response to the common irritant sodium lauryl sulfate but not to ultraviolet radiation challenge matched to generate comparable erythema.
      • Our findings provide insights into pathways involved in irritant dermatitis, with potential translation to novel treatments and new means for assessing contact irritants.
  6. Systematic Reviews

    1. Education to improve quality of life of people with chronic inflammatory skin conditions: a systematic review of the evidence

      K. Pickett, G. Frampton and E. Loveman

      Article first published online: 28 APR 2016 | DOI: 10.1111/bjd.14435

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      What's already known about this topic?

      • People with chronic inflammatory skin conditions can experience poor health-related quality of life (HRQoL).
      • There is mixed evidence about whether patient education improves HRQoL.

      What does this study add?

      • Education often focuses on information about a condition and its treatment. This systematic review examines outcomes of education that specifically aims to improve HRQoL or includes elements that could improve HRQoL.
      • The limited available evidence shows inconsistent HRQoL effects and the need for more theoretically based interventions.
  7. Translational Research

    1. Serum and salivary IgG and IgA antibodies to desmoglein 3 in mucosal pemphigus vulgaris

      S. Ali, C. Kelly, S.J. Challacombe, A.N.A. Donaldson, B.S. Bhogal and J.F. Setterfield

      Article first published online: 27 APR 2016 | DOI: 10.1111/bjd.14410

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      What's already known about this topic?

      • The use of serum to test for IgG autoantibodies to desmoglein (Dsg)3 by enzyme-linked immunosorbent assay has been well documented.
      • Salivary IgG anti-Dsg3 antibodies have been previously detected in three studies in pemphigus vulgaris (PV) and have been proposed as a diagnostic marker.

      What does this study add?

      • This study demonstrates that detection of salivary antibodies provides a practical alternative to serum in the diagnosis of PV. Salivary antibodies may also be used for the monitoring of disease activity in patients with PV.
      • Both IgG and IgA serum antibodies to Dsg3 are detected in IgG-driven PV. Further investigation is needed to understand the role of IgA in the pathogenesis of PV.

      What is the translational message?

      • The simplicity of obtaining a whole saliva sample and the demonstration that anti-Dsg3 IgG antibodies can be easily detected suggests that saliva may become a useful diagnostic screening test for PV.
      • As titres are related to disease activity, repeated noninvasive sampling offers the possibility of routine remote monitoring of disease.
  8. Research Letters

    1. Methotrexate in psoriasis under real-world conditions: long-term efficacy and tolerability

      J. West, S. Ogston, C. Palmer, C. Fleming, R. Dawe, V. Kumar, S. Waterston and J. Foerster

      Article first published online: 26 APR 2016 | DOI: 10.1111/bjd.14452

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  9. Clinical Trials

    1. Oral alitretinoin treatment in patients with palmoplantar pustulosis inadequately responding to standard topical treatment: a randomized phase II study

      K. Reich, O. Graff and N. Mehta

      Article first published online: 26 APR 2016 | DOI: 10.1111/bjd.14401

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      What's already known about this topic?

      • Alitretinoin is a retinoid X receptor and retinoid A receptor agonist with effects on cutaneous inflammation and hyperkeratinization.
      • Findings from earlier uncontrolled studies of alitretinoin indicate that it could be a meaningful treatment option for palmoplantar pustulosis.

      What does this study add?

      • Although the results were unexpected based on previous studies of alitretinoin in the treatment of palmoplantar pustulosis, this study provided no evidence to support further exploration of alitretinoin in the treatment of severe palmoplantar pustulosis.
  10. Translational Research

    1. Characterization of patients at high risk of melanoma in Austria

      C. Müller, J. Wendt, S. Rauscher, S. Burgstaller-Muehlbacher, R. Sunder-Plassmann, C. Scheurecker, E. Richtig, I. Fae, G. Fischer, H. Pehamberger and I. Okamoto

      Article first published online: 26 APR 2016 | DOI: 10.1111/bjd.14407

      What's already known about this topic?

      • Melanoma risk is determined by environmental and genetic risk factors.
      • The frequency and type of disease-causing gene mutations vary between different countries.

      What does this study add?

      • This is the first comprehensive description of Austrian patients at high risk of melanoma.
      • The heterogeneity of the different subgroups suggests diverse pathways.
      • We present functional prediction of MC1R and CDK4 variants with unknown biological significance in high-risk patients, and three novel cases with MITF variants in high-risk patients.

      What is the translational message?

      • Identification of high-risk individuals helps to reduce mortality.
      • The risk of melanoma is comprised of a complex interplay between genetic and environmental factors; however, genetic mutations associated with melanoma might differ from country to country.
      • Knowledge of these mutations and adjustment of criteria for testing could be required for adequate risk assessments.
    2. Common and rare CARD14 gene variants affect the antitumour necrosis factor response among patients with psoriasis

      P. Coto-Segura, D. González-Fernández, A. Batalla, J. Gómez, L. González-Lara, R. Queiro, B. Alonso, S. Iglesias and E. Coto

      Article first published online: 25 APR 2016 | DOI: 10.1111/bjd.14461

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      What's already known about this topic?

      • Patients with psoriasis treated with antitumour necrosis factor (anti-TNF) agents (and other biological therapies) exhibit a heterogeneous response.
      • This could be explained partly by the variability in genes that encode components of immunological pathways.
      • Rare and common CARD14 variants have been linked to the risk for psoriasis, but no study about the effect on anti-TNF response has been reported.

      What does this study add?

      • Our study showed that the CARD14 rs11652075 polymorphism (Arg820Trp) was associated with the response to anti-TNF agents among patients with psoriasis.
      • The genotype that increased the risk for psoriasis was also a significant predictor of a better anti-TNF response, measured as ≥ 75% improvement in Psoriasis Area and Severity Index at week 24.

      What is the translational message?

      • Variants of the CARD14 gene (a regulator of nuclear factor-κB-mediated pathways) have been associated with the overall risk of developing psoriasis in case–control studies.
      • In this work, we show that CARD14 variants are also related to the response to anti-TNF agents.
      • If the results are confirmed by others, the analysis of this gene might help dermatologists to optimize treatment with anti-TNF biological drugs.
    3. Skin expression of mammalian target of rapamycin and forkhead box transcription factor O1, and serum insulin-like growth factor-1 in patients with acne vulgaris and their relationship with diet

      N.F. Agamia, D.M. Abdallah, O. Sorour, B. Mourad and D.N. Younan

      Article first published online: 20 APR 2016 | DOI: 10.1111/bjd.14409

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      What's already known about this topic?

      • A high-glycaemic-load diet and insulin-like growth factor-1 play roles in the induction of acne.
      • Increased mammalian target of rapamycin (mTOR)C1 signalling has been reported in patients with acne compared with healthy controls.

      What does this study add?

      • This study provides immunohistochemical evidence of increased cytoplasmic expression of the metabolic transcription factor FoxO1 and increased expression of mTOR in the skin of patients with acne.
      • We provide experimental evidence supporting the hypothesis of decreased nuclear FoxO1 signalling in patients with acne.

      What is the translational message?

      • Nutritional therapy for acne should (i) normalize total calorie intake, (ii) lower glycaemic load and (iii) restrict total dairy protein consumption.
      • Understanding nutrient signalling may help dermatologists to understand the central role of the Western diet in the pathogenesis and treatment of acne.
      • Our results may offer novel therapeutic strategies for the treatment of acne based on upregulation of nuclear FoxO1.
  11. Research Letters

    1. PSTPIP1 gene mutation in a pyoderma gangrenosum, acne and suppurative hidradenitis (PASH) syndrome

      X. Calderón-Castrat, D. Bancalari-Díaz, C. Román-Curto, A. Romo-Melgar, D. Amorós-Cerdán, L.A. Alcaraz-Mas, E. Fernández-López and J. Cañueto

      Article first published online: 19 APR 2016 | DOI: 10.1111/bjd.14383

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  12. General Dermatology

    1. Carbon dioxide laser ablation of basal cell carcinoma with visual guidance by reflectance confocal microscopy: a proof-of-principle pilot study

      B.P. Hibler, H. Sierra, M. Cordova, W. Phillips, M. Rajadhyaksha, K.S. Nehal and A.M. Rossi

      Article first published online: 19 APR 2016 | DOI: 10.1111/bjd.14414

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      What's already known about this topic?

      • Nonsurgical treatment including laser ablation of skin cancer is limited by lack of histologically confirmed clearance.
      • Reflectance confocal microscopy provides noninvasive, in vivo imaging of skin with cellular-level resolution

      What does this study add?

      • Confocal microscopy can effectively map tumour margins preablation and also detect residual tumour postablation.
      • Carbon dioxide laser ablation guided by confocal microscopy may represent a suitable alternative treatment for low-risk basal cell carcinoma in nonsurgical candidates.
  13. Letters to the Editor

    1. Validation of database search strategies for the epidemiological study of eczema herpeticum

      D.Y. Hsu, B. Nardone, D. West and J.I. Silverberg

      Article first published online: 19 APR 2016 | DOI: 10.1111/bjd.14424

  14. Translational Research

    1. IgE and FcεRI are highly expressed on innate cells in psoriasis

      K-X. Yan, Q. Huang, X. Fang, Z-H. Zhang, L. Han, K. Gadaldi, K-F. Kang, Z-Z. Zheng, J-H. Xu and N. Yawalkar

      Article first published online: 18 APR 2016 | DOI: 10.1111/bjd.14459

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      What's already known about this topic?

      • Serum total IgE levels are elevated in patients with psoriasis.

      What does this study add?

      • The expression of IgE and FcεRI was particularly enhanced on innate cells in psoriatic lesions. The numbers of IgE+ and FcεRI+ cells in psoriatic lesions significantly decreased after treatment with ustekinumab.

      What is the translational message?

      • IgE-mediated mechanisms may perpetuate cutaneous inflammation in a subset of patients with psoriasis.
  15. Letters to the Editor

    1. Short-contact, low-dose methyl aminolaevulinate photodynamic therapy for acne vulgaris

      C. Dessinioti, S. Masouri, E. Drakaki, A. Katsambas and C. Antoniou

      Article first published online: 18 APR 2016 | DOI: 10.1111/bjd.14460

  16. Research Letters

    1. Net-like superficial vascular malformation: clinical description and evidence for lymphatic origin

      L. Noguera-Morel, S.L. Stein, G. Xirotagaros, A. Hernández-Martín, I. de Prada, I.J. Frieden, L. Requena and A. Torrelo

      Article first published online: 18 APR 2016 | DOI: 10.1111/bjd.14404

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  17. General Dermatology

    1. Multicentre study on inflammatory skin diseases from The International Confocal Working Group: specific confocal microscopy features and an algorithmic method of diagnosis

      M. Ardigo, C. Longo, S. Gonzalez and The International Confocal Working Group Inflammatory Skin Diseases Project

      Article first published online: 18 APR 2016 | DOI: 10.1111/bjd.14516

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      What's already known about this topic?

      • Reflectance confocal microscopy has been used successfully for the evaluation of several inflammatory skin diseases.

      What does this study add?

      • Reflectance confocal microscopy provides features useful for diagnosis and differential diagnosis of the major inflammatory skin diseases.
      • An algorithmic method originating from multivariate analysis can be used for the diagnosis.
  18. Research letters

    1. Drug survival for azathioprine and enteric-coated mycophenolate sodium in a long-term daily practice cohort of adult patients with atopic dermatitis

      J. van der Schaft, K. Politiek, J.M.P.A. van den Reek, W. Kievit, E.M.G.J. de Jong, C.A.F.M. Bruijnzeel-Koomen, M.L.A. Schuttelaar and M.S. de Bruin-Weller

      Article first published online: 17 APR 2016 | DOI: 10.1111/bjd.14398

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  19. Case Reports

    1. Topical sodium metabisulfite for the treatment of calcinosis cutis: a promising new therapy

      P. del Barrio-Díaz, C. Moll-Manzur, S. Álvarez-Veliz and C. Vera-Kellet

      Article first published online: 17 APR 2016 | DOI: 10.1111/bjd.14412

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      What's already known about this topic?

      • Calcinosis cutis is a chronic calcium-mediated disease that causes significant morbidity for patients.
      • Multiple treatments have been tried, many of them with varying results and side-effects. To date, no standard treatment has been generally accepted.

      What does this study add?

      • Topical sodium metabisulfite is a new, inexpensive emerging therapy that should be considered as a valid alternative treatment in patients with calcinosis cutis, especially in countries where topical sodium thiosulfate is not available.
  20. Epidemiology

    1. An estimation of the incidence of tuberous sclerosis complex in a nationwide retrospective cohort study (1997–2010)

      C.-H. Hong, H.-P. Tu, J.-R. Lin and C.-H. Lee

      Article first published online: 17 APR 2016 | DOI: 10.1111/bjd.14415

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      What's already known about this topic?

      • Patients with tuberous sclerosis complex (TSC) develop systemic hamartomas with significant psychosocial burdens.
      • Two small epidemiological studies have estimated the incidence of TSC to be 0·28–0·56 per 100 000 person-years (PY) in the U.S.A.

      What does this study add?

      • This 14-year-long longitudinal study estimated the incidence of TSC in Taiwan to be 0·153 per 100 000 PY.
      • The prevalence of TSC in 2010 in Taiwan was 1·58 in 100 000.
      • A significantly lower risk of peptic ulcer is found in patients with TSC compared with healthy controls.
  21. Clinical Trials

    1. Investigation of selective JAK1 inhibitor GSK2586184 for the treatment of psoriasis in a randomized placebo-controlled phase IIa study

      V.J. Ludbrook, K.J. Hicks, K.E. Hanrott, J.S. Patel, M.H. Binks, M.R. Wyres, J. Watson, P. Wilson, M. Simeoni, L.A. Schifano, K. Reich and C.E.M. Griffiths

      Article first published online: 7 APR 2016 | DOI: 10.1111/bjd.14399

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      What's already known about this topic?

      • Inhibition of Janus kinase (JAK) signalling is emerging as an important therapeutic target in the treatment of psoriasis.

      What does this study add?

      • This study shows that GSK2586184 is efficacious in the treatment of plaque psoriasis over a 12-week period.
      • Our results suggest that JAK1 selective inhibition may be an effective treatment option for patients with plaque-type psoriasis, without the laboratory changes seen with broader JAK inhibition.
      • Our study details the gene expression profile changes observed in uninvolved and involved skin at baseline and in involved skin after 2 weeks of treatment with GSK2586184.
  22. Case Reports

    1. Two cases of overlap severe cutaneous adverse reactions to benznidazole treatment for asymptomatic Chagas disease in a nonendemic country

      J. González-Ramos, L. Noguera-Morel, H.Y. Tong, E. Ramírez, E. Ruiz-Bravo, T. Bellón, R. Cabañas, L. Cachafeiro and P. Herranz-Pinto

      Article first published online: 7 APR 2016 | DOI: 10.1111/bjd.14451

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      What's already known about this topic?

      • Cutaneous reactions to benznidazole are common; however, severe cases have rarely been reported.

      What does this study add?

      • Benznidazole may induce potentially life-threatening severe cutaneous adverse reactions.
      • There should be greater awareness among physicians of this newly reported risk.
  23. Clinical Trials

    1. You have full text access to this OnlineOpen article
      A randomized phase 2b trial of baricitinib, an oral Janus kinase (JAK) 1/JAK2 inhibitor, in patients with moderate-to-severe psoriasis

      K.A. Papp, M.A. Menter, M. Raman, D. Disch, D.E. Schlichting, C. Gaich, W. Macias, X. Zhang and J.M. Janes

      Article first published online: 5 APR 2016 | DOI: 10.1111/bjd.14403

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      What's already known about this topic?

      • Psoriasis is a common, chronic, immune-mediated inflammatory skin disease.
      • Key cytokines involved in the pathogenesis of psoriasis use the Janus kinase–signal transducer and activator of transcription (JAK-STAT) pathway.
      • New safe and effective therapies are needed for patients.

      What does this study add?

      • Baricitinib, a selective JAK1/JAK2 inhibitor, demonstrates clinical efficacy in the treatment of psoriasis.
      • Baricitinib was well tolerated over the 24-week trial period.
  24. General Dermatology

    1. You have full text access to this OnlineOpen article
      The 2016 International League of Dermatological Societies' revised glossary for the description of cutaneous lesions

      A. Nast, C.E.M. Griffiths, R. Hay, W. Sterry and J.L. Bolognia

      Article first published online: 3 APR 2016 | DOI: 10.1111/bjd.14419

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      What's already known about this topic?

      • A unifying language and precise descriptions are key to the practice of dermatology.
      • The International League of Dermatological Societies (ILDS) first published a ‘Glossary of basic dermatology lesions’ in 1987.

      What does this study add?

      • This is an entirely updated and revised version of the 1987 ILDS glossary.
      • The revised nomenclature is written with both dermatologists and nondermatologists in mind.
  25. Medical Dermatology

    1. Calculation of cut-off values based on the Autoimmune Bullous Skin Disorder Intensity Score (ABSIS) and Pemphigus Disease Area Index (PDAI) pemphigus scoring systems for defining moderate, significant and extensive types of pemphigus

      C. Boulard, S. Duvert Lehembre, C. Picard-Dahan, J.S. Kern, G. Zambruno, C. Feliciani, B. Marinovic, P. Vabres, L. Borradori, C. Prost-Squarcioni, B. Labeille, M.A. Richard, S. Ingen-Housz-Oro, E. Houivet, V.P. Werth, D.F. Murrell, M. Hertl, J. Benichou, P. Joly and on behalf of the International Pemphigus Study Group

      Article first published online: 3 APR 2016 | DOI: 10.1111/bjd.14405

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      What's already known about this topic?

      • The Autoimmune Bullous Skin Disorder Intensity Score (ABSIS) and Pemphigus Disease Area Index (PDAI) are new scoring systems to measure pemphigus activity.
      • The use of these scores in clinical practice is limited by the absence of cut-off values.

      What does this study add?

      • Cut-off values distinguishing moderate, significant and extensive pemphigus were 15 and 45 for PDAI, and 17 and 53 for ABSIS.
      • These disease activity subgroups should help physicians in the management of patients with pemphigus.
  26. Letters to the Editor

  27. Epidemiology

    1. The prevalence of actinic keratosis in patients visiting dermatologists in two hospitals in China

      Y. Zhao, C.Y. Li, C.M. Wen, Y.B. Wei, R.Y. Li, G. Wang and P. Tu

      Article first published online: 31 MAR 2016 | DOI: 10.1111/bjd.14344

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      What's already known about this topic?

      • Actinic keratosis is one of the most common conditions treated by dermatologists in western countries.

      What does this study add?

      • The overall prevalence of actinic keratoses in patients visiting dermatologists was 0.52% in two hospitals in China, which is much lower than in western countries.
  28. Letters to the Editor

    1. Delayed oral toxicity from long-term vemurafenib therapy

      A. Lloyd-Lavery, T. Hodgson, N. Coupe, S. Bond, K. Shah, O. Espinosa, M.J. Payne, M.R. Middleton and R.N. Matin

      Article first published online: 30 MAR 2016 | DOI: 10.1111/bjd.14457

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  29. Research Letters

    1. Characteristics of actinic prurigo in Scotland: 24 cases seen between 2001 and 2015

      L. Macfarlane, S. Hawkey, H. Naasan and S. Ibbotson

      Article first published online: 30 MAR 2016 | DOI: 10.1111/bjd.14444

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  30. Systematic Reviews

    1. You have full text access to this OnlineOpen article
      Interventions for hidradenitis suppurativa: a Cochrane systematic review incorporating GRADE assessment of evidence quality

      J.R. Ingram, P.N. Woo, S.L. Chua, A.D. Ormerod, N. Desai, A.C. Kai, K. Hood, T. Burton, F. Kerdel, S.E. Garner and V. Piguet

      Article first published online: 30 MAR 2016 | DOI: 10.1111/bjd.14418

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      What's already known about this topic?

      • Many interventions have been tried for hidradenitis suppurativa (HS).
      • Evidence supporting the choice of intervention for HS is often limited.

      What does this study add?

      • Moderate-quality evidence suggests that adalimumab given weekly and infliximab are effective, whereas adalimumab every other week is ineffective.
      • There are very limited or no randomized controlled trial data in HS for antibiotic therapy, retinoids, oral immunomodulators or the timing and type of surgery to perform.
  31. Research Letters

    1. Laboratory diagnosis of pemphigus: direct immunofluorescence remains the gold standard

      F. Giurdanella, G.F.H. Diercks, M.F. Jonkman and H.H. Pas

      Article first published online: 27 MAR 2016 | DOI: 10.1111/bjd.14408

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  32. Medical Dermatology

    1. You have full text access to this OnlineOpen article
      Continuous usage of a hair dye product containing 2-methoxymethyl-para-phenylenediamine by hair-dye-allergic individuals

      M. Kock, P.-J. Coenraads, B. Blömeke and C. Goebel

      Article first published online: 27 MAR 2016 | DOI: 10.1111/bjd.14390

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      What's already known about this topic?

      • Individuals allergic to para-phenylenediamine (PPD) have shown a lower response rate to forearm testing simulating hair dye use when the hair dye product contained 2-methoxymethyl (ME)-PPD instead of PPD.

      What does this study add?

      • This study investigates whether PPD-allergic individuals tolerate full hair dyeing with their selected ME-PPD hair dye shade, if they did not respond to forearm pretesting with that hair dye at day 2.
    2. High prevalence of psychiatric disorders in patients with skin-restricted lupus: a case–control study

      I. Jalenques, F. Rondepierre, C. Massoubre, E. Haffen, J.P. Grand, B. Labeille, J.L. Perrot, F. Aubin, F. Skowron, A. Mulliez, M. D'Incan and The Lupus Group

      Article first published online: 27 MAR 2016 | DOI: 10.1111/bjd.14392

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      What's already known about this topic?

      • No data exist about psychiatric disorders in patients with skin-restricted lupus (SRL).

      What does this study add?

      • Patients with SRL have a high prevalence of current and lifetime major depressive disorder, generalized anxiety disorder and panic disorder, current suicide risk, alcohol dependence and lifetime agoraphobia.
      • Patients with SRL often lack specialized mental health care.
  33. Letters to the Editor

  34. Systematic Reviews

    1. Evidence-based management of vitiligo: summary of a Cochrane systematic review

      M. Whitton, M. Pinart, J.M. Batchelor, J. Leonardi-Bee, U. Gonzalez, Z. Jiyad, V. Eleftheriadou and K. Ezzedine

      Article first published online: 25 MAR 2016 | DOI: 10.1111/bjd.14356

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      What's already known about this topic?

      • Vitiligo is a skin disease with limited treatment options.
      • Most of the published vitiligo clinical trials are of poor methodological quality.

      What does this study add?

      • There are still important variations in study design and outcome measures in vitiligo clinical trials.
      • Individual trials showed short-term benefit from topical corticosteroids and various forms of ultraviolet combined with topical preparations.
      • Long-term follow-up and patient-rated outcomes should be incorporated into study design, and more studies should assess psychological interventions.
  35. Translational Research

    1. The role of PSMB9 upregulated by interferon signature in the pathophysiology of cutaneous lesions of dermatomyositis and systemic lupus erythematosus

      K. Nakamura, M. Jinnin, H. Kudo, K. Inoue, W. Nakayama, N. Honda, I. Kajihara, S. Masuguchi, S. Fukushima and H. Ihn

      Article first published online: 25 MAR 2016 | DOI: 10.1111/bjd.14385

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      What's already known about this topic?

      • Dermatomyositis (DM) and systemic lupus erythematosus (SLE) have common skin features, including dermal mucin deposition and interferon signature.

      What does this study add?

      • PSMB9 and versican V1, a core protein for glycosaminoglycan, were upregulated, while type I collagen was downregulated in both DM and SLE skin.
      • The interferon signature reduces collagen in dermal fibroblasts of DM and SLE skin, while interferon-induced PSMB9 overexpression induces transforming growth factor (TGF)-β2/β3 in epidermal keratinocytes, which results in versican overexpression in dermal fibroblasts.
      • The TGF-β2–ΔDiHS-diS1 pathway is responsible for the specific molecular changes to DM skin.

      What is the translational message?

      • PSMB9 in the skin of patients with dermatomyositis and systemic lupus erythematosus has great potential as a diagnostic and therapeutic tool.
  36. Letters to the Editor

  37. Medical Dermatology

    1. Clinical significance of serum YKL-40 in Behçet disease

      J. Seo, Y. Ahn, Z. Zheng, B.O. Kim, M.J. Choi, D. Bang and D.Y. Kim

      Article first published online: 23 MAR 2016 | DOI: 10.1111/bjd.14376

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      What's already known about this topic?

      • YKL-40, secreted by activated macrophages and neutrophils, is a potential biomarker of inflammation and endothelial dysfunction.
      • Behçet disease (BD) is a chronic multisystemic inflammatory disease, characterized by neutrophil hyperactivation and endothelial injury with subsequent dysfunction.

      What does this study add?

      • Serum YKL-40 levels are increased in patients with BD and positively correlate with disease activity.
      • YKL-40 may play a role in the pathophysiology of BD and could provide a useful marker for monitoring patients with BD.
  38. Research Letters

    1. You have full text access to this OnlineOpen article
      The Predict Study: low risk for digital ulcer development in patients with systemic sclerosis with increasing disease duration and lack of topoisomerase-1 antibodies

      N. Hunzelmann, G. Riemekasten, M.O. Becker, P. Moinzadeh, A. Kreuter, I. Melchers, U. Mueller-Ladner, F. Meier, M. Worm, H. Lee, I. Herrgott, C. Pfeiffer, G. Fierlbeck, J. Henes, A. Juche, G. Zeidler, H. Mensing, C. Günther, M. Sárdy, H. Burkhardt, M. Koehm, K. Kuhr, T. Krieg and C. Sunderkötter

      Article first published online: 20 MAR 2016 | DOI: 10.1111/bjd.14367

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  39. Case Reports

    1. [18F]-Fluorodeoxy-d-glucose uptake-positive seborrhoeic keratosis on positron emission tomography may result from high expression of glucose transporter

      T. Kariya, Y. Kato, A. Kanzaki, Y. Kanda, T. Ohara and R. Tsuboi

      Article first published online: 20 MAR 2016 | DOI: 10.1111/bjd.14421

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      What's already known about this topic?

      • [18F]-Fluorodeoxy-d-glucose (FDG) positron emission tomography–computed tomography (PET-CT) is known to be highly accurate in differentiating benign lesions from malignant lesions.
      • In rare cases, benign tumours, viral infections and sarcoidosis of the skin have been reported to show FDG uptake, but the mechanism remains unclear.

      What does this study add?

      • We report, for the first time, a case of seborrhoeic keratosis (SK) with increased FDG uptake.
      • The expression of glucose transporter (GLUT)1 and GLUT3 was higher in PET- positive SK than in PET-negative SK or in normal skin.
      • High expression of GLUT1 and GLUT3 in benign tumours like SK, as in this case, might be associated with the uptake of FDG.
  40. Letters to the Editor

    1. Successful rapid subcutaneous desensitization to anakinra in a case of delayed-type hypersensitivity reaction

      V. Leroy, E. Lazaro, A.-S. Darrigade, A. Taïeb, B. Milpied and J. Seneschal

      Article first published online: 20 MAR 2016 | DOI: 10.1111/bjd.14454

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  41. Research Letters

    1. Evaluation of learning disabilities in segmental neurofibromatosis

      E. Marmottant-Debled, C. Chiaverini, C. Fossoud, T. Passeron, S. Barbarot and J.-P. Lacour

      Article first published online: 20 MAR 2016 | DOI: 10.1111/bjd.14436

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    2. Atopic dermatitis (eczema) in US female nurses: lifestyle risk factors and atopic comorbidities

      A.M. Drucker, W.-Q. Li, L. Lin, E. Cho, T. Li, C.A. Camargo Jr and A.A. Qureshi

      Article first published online: 18 MAR 2016 | DOI: 10.1111/bjd.14373

  42. General Dermatology

    1. Fluorescence excitation photography of epidermal cellular proliferation

      E. Gutierrez-Herrera, A.E. Ortiz, A. Doukas and W. Franco

      Article first published online: 18 MAR 2016 | DOI: 10.1111/bjd.14400

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      What's already known about this topic?

      • According to the concept of endogenous fluorescence or autofluorescence of skin, certain molecules native to skin fluoresce or emit light upon illumination.
      • Endogenous fluorescence has been used as a clinical research method. Fluorescence spectra or maps are acquired by spectroscopy and subsequently correlated to physiology.

      What does this study add?

      • This study demonstrates the effectiveness of a novel ultraviolet fluorescence excitation photography system in its ability to image rapidly proliferating epidermal skin lesions by capturing endogenous fluorescence emissions.
      • The images captured using this method are instantly available and do not require interpretation or reconstruction.
  43. Research Letters

    1. Bullous pemphigoid suggestive of complement-independent blister formation with anti-BP180 IgG4 autoantibodies

      T. Dainichi, W. Nishie, Y. Yamagami, H. Sonobe, H. Ujiie, Y. Kaku and K. Kabashima

      Article first published online: 18 MAR 2016 | DOI: 10.1111/bjd.14411

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  44. Case Reports

    1. Extensive tumoral melanosis associated with ipilimumab-treated melanoma

      K. Staser, D. Chen, J. Solus, I.S. Rosman, A. Schaffer, L. Cornelius, G.P. Linette and R.C. Fields

      Article first published online: 18 MAR 2016 | DOI: 10.1111/bjd.14474

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      What's already known about this topic?

      • Limited tumoral melanosis occurs in the context of regressed melanoma.
      • Ipilimumab activates the immune system and promotes tumour killing.

      What does this study add?

      • This study shows tumoral melanosis to an extent previously not described.
      • This extensive melanosis occurred in the context of ipilimumab treatment, suggesting that activated immunity may result in aggressive melanophagocytosis.
  45. Letters to the Editor

  46. Clinical Trials

    1. Pulse photodynamic therapy reduces inflammation without compromising efficacy in the treatment of multiple mild actinic keratoses of the face and scalp: a randomized clinical trial

      S.R. Wiegell, B. Petersen and H.C. Wulf

      Article first published online: 15 MAR 2016 | DOI: 10.1111/bjd.14465

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      What's already known about this topic?

      • One important side-effect in photodynamic therapy (PDT) of actinic keratoses (AKs) is post-treatment erythema, which enhances patient down time.
      • Corticosteroid use before and just after PDT can reduce treatment-induced erythema.

      What does this study add?

      • Pulse-PDT (30-min methyl aminolaevulinate, illumination after 3 h) and especially corticosteroid pulse-PDT reduced treatment-induced erythema without affecting the efficacy of the treatment of multiple mild AKs.
      • Pulse-PDT and topical corticosteroids may make PDT treatment of large areas more acceptable.
  47. Translational Research

    1. Infiltration of M2-polarized macrophages in infected lymphatic malformations: possible role in disease progression

      W. Zhang, K.-F. He, J.-G. Yang, J.-G. Ren, Y.-F. Sun, J.-H. Zhao and Y.-F. Zhao

      Article first published online: 15 MAR 2016 | DOI: 10.1111/bjd.14471

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      What's already known about this topic?

      • Infection in lymphatic malformations (LMs) promotes the development of the disease.
      • Tertiary lymphoid organs (TLOs) are found in most LMs.
      • Macrophages intensively promote lymphangiogenesis in pathological conditions.

      What does this study add?

      • M2-polarized macrophages are increased in LMs compared with skin tissues.
      • A close relationship between M2-polarized macrophages and TLOs was uncovered in LMs.
      • M2-polarized macrophages and TLOs might contribute to the progression of LMs after infection.

      What is the translational message?

      • Infection or inflammation in LMs indicated poor prognosis of the disease.
      • Targeting M2-polarized macrophages might be a promising therapy for LMs.
      • Targeting TLO formation might alleviate the progression of LMs by reducing macrophage recruitment and lymphatic vessel formation.
  48. Epidemiology

    1. Epidemiology of chronic spontaneous urticaria: results from a nationwide, population-based study in Italy

      F. Lapi, N. Cassano, V. Pegoraro, N. Cataldo, F. Heiman, I. Cricelli, M. Levi, D. Colombo, E. Zagni, C. Cricelli and G.A. Vena

      Article first published online: 15 MAR 2016 | DOI: 10.1111/bjd.14470

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      What's already known about this topic?

      • Precise information on the epidemiology of chronic spontaneous urticaria (CSU) in Italy is lacking.

      What does this study add?

      • Annual incidence and prevalence rates of CSU in Italy were calculated from 2002 to 2013 using data from a national database of general practitioners.
      • Demographic and clinical determinants associated with the occurrence of CSU were determined.
  49. Letters to the Editor

  50. Medical Dermatology

    1. Pathophysiology of pruritus in primary localized cutaneous amyloidosis

      H.L. Tey, T. Cao, L.A. Nattkemper, V.W.D. Tan, Z.A.D. Pramono and G. Yosipovitch

      Article first published online: 15 MAR 2016 | DOI: 10.1111/bjd.14391

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      What's already known about this topic?

      • Itch is frequently associated with primary localized cutaneous amyloidosis (PLCA) and can be debilitating; its pathophysiology is unknown.

      What does this study add?

      • Small-fibre neuropathy is present in PLCA.
      • Pruritus in PLCA is likely associated with hypersensitivity of cutaneous nerve fibres, which may be related to an increased expression of epidermal interleukin (IL)-31 receptors.
      • Targeting IL-31 receptors is a potential therapeutic approach.
  51. Letters to the Editor

  52. Epidemiology

    1. Atopic dermatitis is not associated with actinic keratosis: cross-sectional results from the Rotterdam study

      E. Hajdarbegovic, H. Blom, J.A.C. Verkouteren, A. Hofman, L.M. Hollestein and T. Nijsten

      Article first published online: 14 MAR 2016 | DOI: 10.1111/bjd.14423

      What's already known about this topic?

      • Patients with severe atopic dermatitis (AD) treated with ultraviolet therapy and immunosuppressants are at an increased risk of keratinocyte malignancies.

      What does this study add?

      • Community-dwelling, average patients with AD do not have more actinic keratoses or keratinocyte cancers than those without AD.
      • There is no support for extra actinic keratosis and keratinocyte cancer screening in patients with mild-to-moderate AD.
  53. Letters to the Editor

  54. Research Letters

  55. Translational Research

    1. Salivary IgA and IgG antibodies to bullous pemphigoid 180 noncollagenous domain 16a as diagnostic biomarkers in mucous membrane pemphigoid

      S. Ali, C. Kelly, S.J. Challacombe, A.N.A. Donaldson, J.K.G. Dart, M. Gleeson, the MMP Study Group 2009–14 and J.F. Setterfield

      Article first published online: 7 MAR 2016 | DOI: 10.1111/bjd.14351

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      What's already known about this topic?

      • The use of serum to test for specific IgG and IgA autoantibodies to epitopes on bullous pemphigoid antigen II (BP180; collagen XVII) by enzyme-linked immunosorbent assay has been documented.
      • Circulating autoantibodies may relate to disease activity and have been reported to be associated with a more severe clinical presentation in mucous membrane pemphigoid (MMP).

      What does this study add?

      • The study demonstrates for the first time that saliva provides a practical alternative to serum in the diagnosis of MMP as IgG and IgA antibodies to BP180-NC16a can be detected in saliva.
      • The detection of secretory IgA antibodies is demonstrated for the first time and indicates local production of autoantibodies to the noncollagenous domain of BP180. This may help provide more insight into the pathogenesis of the disease.
  56. Case Reports

    1. Amelioration of junctional epidermolysis bullosa due to exon skipping

      C. Kowalewski, J. Bremer, A. Gostynski, K. Wertheim-Tysarowska, K. Wozniak, J. Bal, M.F. Jonkman and A.M.G. Pasmooij

      Article first published online: 6 MAR 2016 | DOI: 10.1111/bjd.14374

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      What's already known about this topic?

      • Revertant mosaicism is a naturally occurring event that relies on the spontaneous correction of a pathogenic mutation.
      • Antisense oligonucleotide-mediated exon skipping is a new gene therapy that is under investigation for the treatment of epidermolysis bullosa.

      What does this study add?

      • We identified a patient with junctional epidermolysis bullosa with two correction mechanisms both leading to in-frame skipping of the mutated exon 49 in the COL17A1 gene – (i) premature termination codon-induced exon skipping and (ii) correction of the inherited mutation by a spontaneous somatic splice-site mutation.
      • Our data support the use of antisense oligonucleotide-mediated exon skipping as a therapeutic approach for epidermolysis bullosa.
  57. Research Letters

    1. Skin and soft tissue infections and acute kidney injury: a systematic review

      S.R. Wilkes, E. Burden-Teh, F. Robertson, D. Grindlay and N.M. Selby

      Article first published online: 3 MAR 2016 | DOI: 10.1111/bjd.14368

    2. Gene expression profiling of skin and blood in hidradenitis suppurativa

      J.L. Blok, K. Li, C. Brodmerkel, M.F. Jonkman and B. Horváth

      Article first published online: 2 MAR 2016 | DOI: 10.1111/bjd.14371

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    3. Ten years of DNA diagnostics of epidermolysis bullosa in the Czech Republic

      L. Kopečková, H. Bučková, J. Kýrová, R. Gaillyová, J. Němečková, B. Jeřábková, K. Veselý, K. Stehlíková and L. Fajkusová

      Article first published online: 1 MAR 2016 | DOI: 10.1111/bjd.14370

  58. Letters to the Editor

    1. Bimatoprost solution 0·03% topical application to the eyelid margin for the treatment of eyelash hypotrichosis

      N.R. Arujuna, E.J. Topham, L.R. Atkinson, S.M.C. George, E.K. Derrick and P.B.J. Farrant

      Article first published online: 1 MAR 2016 | DOI: 10.1111/bjd.14472

  59. General Dermatology

    1. Airborne formaldehyde causes skin barrier dysfunction in atopic dermatitis

      J. Kim, Y. Han, J.H. Ahn, S.W. Kim, S.I. Lee, K.H. Lee and K. Ahn

      Article first published online: 28 FEB 2016 | DOI: 10.1111/bjd.14357

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      What's already known about this topic?

      • For the proper management of atopic dermatitis (AD), aggravating factors in the environment must be identified and controlled.
      • For example, foods, inhalant allergens, and microorganisms such as bacteria and viruses are well-known factors that can exacerbate AD symptoms.
      • Epidemiological studies have implicated air pollutants and their associated hazardous effects in AD, but these studies have not provided direct evidence for causality.

      What does this study add?

      • We used a provocation test device that we developed for topical stimulation of the skin in children, and found that airborne formaldehyde increases transepidermal water loss and skin pH in healthy children and more prominently in patients with AD.
      • We revealed the causal relationship between airborne formaldehyde and skin barrier dysfunction in children with AD.
      • Exposure to airborne formaldehyde must be avoided to prevent aggravation of AD.
  60. Research Letters

  61. Review Articles

    1. Cutaneous manifestations of Helicobacter cinaedi: a review

      S. Shimizu and H. Shimizu

      Article first published online: 18 FEB 2016 | DOI: 10.1111/bjd.14353

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      What's already known about this topic?

      • Helicobacter cinaedi causes bacteraemia and cellulitis in immunodeficient individuals; however, details of the cutaneous manifestations and their management are not fully described.

      What does this study add?

      • The cutaneous manifestations, epidemiology and management of H. cinaedi infection are described in detail. Helicobacter cinaedi cellulitis, which appears as multiple painful infiltrated erythemas on the extremities, is the most common cutaneous symptom of H. cinaedi bacteraemia.
  62. Letters to the Editor

    1. Association of Cole disease with novel heterozygous mutations in the somatomedin-B domains of the ENPP1 gene: necessary, but not always sufficient

      N.A. Schlipf, H. Traupe, Y. Gilaberte, W.K. Peitsch, I. Hausser, V. Oji, A. Schmieder, S.W. Schneider, P. Demmer, B. Rösler and J. Fischer

      Article first published online: 18 FEB 2016 | DOI: 10.1111/bjd.14328

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    2. Early-onset dermatosis papulosa nigra

      O. Veraitch, W. Rickaby, A. Robson, E. Higgins and J.E. Mellerio

      Article first published online: 17 FEB 2016 | DOI: 10.1111/bjd.14324

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  63. Research Letters

  64. Letters to the Editor

    1. Unique coexistence of cold and solar urticaria and its efficient treatment

      S. Zimmer, A. Peveling-Oberhag, A. Weber, T. Gilfert, U. Rady-Pizarro and P. Staubach

      Article first published online: 11 FEB 2016 | DOI: 10.1111/bjd.14354

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  65. Case Reports

    1. Kaposi sarcoma secondary to endogenous adrenocorticotropic hormone-dependent Cushing syndrome

      A. Mayor-Ibarguren, M.C. Roldán-Puchalt, T. Sancho-Bueso, C. Pérez-López, J. Álvarez-Linera, R. Frutos, C. Álvarez-Escolá, R. Regojo-Zapata, M.J. Beato-Merino, P. Herranz-Pinto and B. Lecumberri

      Article first published online: 11 FEB 2016 | DOI: 10.1111/bjd.14360

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      What's already known about this topic?

      • Kaposi sarcoma (KS) is an angioproliferative disorder related to human herpesvirus 8 infection and immune dysfunction.

      What does this study add?

      • We report a case of a multicentric advanced KS secondary to Cushing syndrome due to an adrenocorticotropic hormone-secreting pituitary microadenoma.
      • This association has rarely been reported, and this case adds evidence to include endogenous Cushing syndrome as a possible cause of KS.
  66. Research Letters

    1. Systemic treatments in childhood psoriasis: a French multicentre study on 154 children

      L. Charbit, E. Mahé, A. Phan, C. Chiaverini, F. Boralevi, E. Bourrat, A. Lasek, A. Maruani, F. Aubin, C. Droitcourt, S. Barbarot, S. Mallet, J. Mazereeuw-Hautier, E. Begon, C. Abasq, P. Plantin, A.-L. Souillet, S. Hadj-Rabia, A.-C. Bursztejn and For the Groupe de Recherche de la Société Française de Dermatologie Pédiatrique

      Article first published online: 11 FEB 2016 | DOI: 10.1111/bjd.14326

  67. Translational Research

    1. Tumour necrosis factor-α plays a significant role in the Aldara-induced skin inflammation in mice

      H. Vinter, K. Kragballe, T. Steiniche, M. Gaestel, L. Iversen and C. Johansen

      Article first published online: 8 FEB 2016 | DOI: 10.1111/bjd.14320

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      What's already known about this topic?

      • The proinflammatory cytokine tumour necrosis factor (TNF)-α is prevalent in many inflammatory diseases, including psoriasis.
      • Not much attention has been given to the role of TNF-α in the frequently used Aldara-induced skin inflammation model.

      What does this study add?

      • Mice constitutively lacking the expression of TNF-α developed significantly less Aldara-induced skin inflammation compared with wild-type mice, strengthening the importance of the use of this model in the study of psoriasis.
  68. Letters to the Editor

    1. Primary amelanotic rhabdoid melanoma of the forehead

      I. Fernández-Vega, J. Santos-Juanes and M.F. Fresno-Forcelledo

      Article first published online: 4 FEB 2016 | DOI: 10.1111/bjd.14382

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  69. Research Letters

    1. Herpes zoster in patients with bullous pemphigoid: a population-based case–control and cohort study

      B.J. Barrick, J.D. Barrick, C.H. Weaver, C.M. Lohse, C.N. Wieland, A.N. Kalaaji and J.S. Lehman

      Article first published online: 4 FEB 2016 | DOI: 10.1111/bjd.14321

    2. Pigmented epithelioid melanocytoma: clinical, dermoscopic and histopathological features

      E. Moscarella, R. Ricci, G. Argenziano, A. Lallas, C. Longo, M. Lombardi, R. Alfano and G. Ferrara

      Article first published online: 28 JAN 2016 | DOI: 10.1111/bjd.14322

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  70. Case Reports

    1. Premenstrual flares of pyoderma gangrenosum controlled with use of a combined oral contraceptive and antiandrogen (ethinyl estradiol/drospirenone)

      N. Jourabchi, S.M. Rhee and G.S. Lazarus

      Article first published online: 28 JAN 2016 | DOI: 10.1111/bjd.14332

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      What's already known about this topic?

      • The literature describes a positive role of oestrogen and a negative role of androgens, or androgen receptor activation, in cutaneous wound healing.
      • There are reports of premenstrual flares in dermatological conditions such as hidradenitis suppurativa and acne vulgaris.

      What does this study add?

      • Patients with pyoderma gangrenosum (PG) can have premenstrual PG flares.
      • We were able to control our patient's premenstrual PG flares with the use of a combined oral contraceptive and antiandrogen (ethinyl estradiol/drospirenone).
  71. Research Letters

    1. The influence of religious/spiritual well-being on quality of life in dermatological disease

      H.F. Unterrainer, M. Lukanz, M. Pilch, S. Scharf, M. Glawischnig-Goschnik, N. Wutte, R. Fink-Puches and E. Aberer

      Article first published online: 28 JAN 2016 | DOI: 10.1111/bjd.14359

    2. Clinical and dermoscopic characteristics of extramammary Paget disease: a study of 35 cases

      J.-H. Mun, S.-M. Park, G.-W. Kim, M. Song, H.-S. Kim, H.-C. Ko, B.-S. Kim and M.-B. Kim

      Article first published online: 28 JAN 2016 | DOI: 10.1111/bjd.14300

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  72. General Dermatology

    1. The contributions of adjusted ambient ultraviolet B radiation at place of residence and other determinants to serum 25-hydroxyvitamin D concentrations

      D. Kelly, E. Theodoratou, S.M. Farrington, R. Fraser, H. Campbell, M.G. Dunlop and L. Zgaga

      Article first published online: 24 JAN 2016 | DOI: 10.1111/bjd.14296

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      What's already known about this topic?

      • Solar ultraviolet B (UVB) radiation is the major source of vitamin D (vitD) for humans and it is strongly associated with vitD status.
      • UVB radiation at wavelengths that can induce vitD synthesis can be approximated by total UV or UVB radiation, sunshine hours or latitude, typically averaged over a large geographical region and long time period, yielding unreliable approximations.

      What does this study add?

      • Information on ambient UVB exposure at wavelengths required for vitD synthesis (vitD-UVB), adjusted for cloud cover and ozone layer, is a powerful yet underutilized tool to study the relationships between UVB, vitD and health outcomes.
      • There was significant geographical variation in vitD-UVB, even within a small geographical area at a northern latitude.
      • Measured ambient vitD-UVB dose at place of residence is a good predictor of vitD status.
  73. Research Letters

    1. Can antioxidant-rich blackcurrant juice drink consumption improve photoprotection against ultraviolet radiation?

      S. Ray, J.J. Belch, A.M. Craigie, F. Khan, G. Kennedy, A. Hill, K.L. Barton, R.S. Dawe and S.H. Ibbotson

      Article first published online: 24 JAN 2016 | DOI: 10.1111/bjd.14299

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  74. General Dermatology

    1. Dermoscopic clues to differentiate facial lentigo maligna from pigmented actinic keratosis

      A. Lallas, P. Tschandl, A. Kyrgidis, W. Stolz, H. Rabinovitz, A. Cameron, J.Y. Gourhant, J. Giacomel, H. Kittler, J. Muir, G. Argenziano, R. Hofmann-Wellenhof and I. Zalaudek

      Article first published online: 20 JAN 2016 | DOI: 10.1111/bjd.14355

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      What's already known about this topic?

      • Dermoscopy is insufficient to differentiate between lentigo maligna (LM) and pigmented actinic keratosis (PAK).

      What does this study add?

      • White and evident follicles, scales and red colour represent significant diagnostic clues for PAK.
      • Intense pigmentation and grey rhomboidal lines appear highly suggestive of LM.
      • These novel findings might improve the early detection of LM, while reducing unnecessary biopsies for PAK.
  75. Research Letters

  76. Case Reports

    1. Paediatric necrolytic migratory erythema as a presenting sign of glucagonoma syndrome

      A.J. Luber, L.S. Ackerman, K.S. Culpepper, C.M. Buschmann and L.J. Koep

      Article first published online: 20 JAN 2016 | DOI: 10.1111/bjd.14298

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      What's already known about this topic?

      • Necrolytic migratory erythema often presents as the first clinical sign in glucagonoma syndrome.
      • The majority of cases occur in the fifth decade of life, with no paediatric cases previously reported.

      What does this study add?

      • We present the first reported case of a paediatric patient with necrolytic migratory erythema as the presenting sign of a localized glucagonoma.
      • Recognition of necrolytic migratory erythema in patients of all ages can aid in the early diagnosis and treatment of glucagonomas.
  77. Research Letters

  78. Surgical Dermatology

    1. Long-term benefit of liposuction in patients with lipoedema: a follow-up study after an average of 4 and 8 years

      A. Baumgartner, M. Hueppe and W. Schmeller

      Article first published online: 26 DEC 2015 | DOI: 10.1111/bjd.14289

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      What's already known about this topic?

      • The longest follow-up studies after liposuction performed in patients with lipo-edema were performed over an average period of 4 years.

      What does this study add?

      • This study adds new information concerning specific complaints after an average period of 8 years following liposuction in patients with lipoedema.
      • These complaints include oedema, spontaneous pain, sensitivity to pressure, bruising, restriction of movement, cosmetic impairment and reduction in quality of life.
  79. Scholarly Reviews

    1. Pyoderma gangrenosum and Sweet syndrome: the prototypic neutrophilic dermatoses

      D. Wallach and M.-D. Vignon-Pennamen

      Article first published online: 22 JUL 2015 | DOI: 10.1111/bjd.13955

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      What's already known about this topic?

      • Pyoderma gangrenosum and Sweet syndrome are the prototypic conditions of the vast group of the neutrophilic dermatoses, characterized by an aseptic infiltration of the skin by polymorphonuclear leucocytes.
      • A similar infiltration may also occur in internal organs, defining the neutrophilic disease.
      • The principles of the management of patients with a neutrophilic disease have been properly described.

      What does this study add?

      • The genetic and molecular mechanisms of neutrophilic inflammation are currently poorly understood.
      • They may be similar to the mechanisms of the monogenic autoinflammatory diseases, which are among the rare causes of neutrophilic dermatoses.

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