British Journal of Dermatology

Cover image for Vol. 175 Issue 4

Early View (Online Version of Record published before inclusion in an issue)

Editor: Alex Anstey, Bangor, UK

Impact Factor: 4.317

ISI Journal Citation Reports © Ranking: 2015: 5/61 (Dermatology)

Online ISSN: 1365-2133

Associated Title(s): Clinical and Experimental Dermatology

VIEW

  1. 1 - 64
  1. Letters to the Editor

    1. You have full text access to this OnlineOpen article
      Mutations in POGLUT1 in Galli–Galli/Dowling–Degos disease

      N.J. Wilson, C. Cole, K. Kroboth, W.N. Hunter, J.A. Mann, W.H.I. McLean, K. Kernland Lang, H. Beltraminelli, R.A. Sabroe, N. Tiffin, G.J. Sobey, L. Borradori, E. Simpson and F.J.D. Smith

      Version of Record online: 24 SEP 2016 | DOI: 10.1111/bjd.14914

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  2. General Dermatology

    1. Accuracy of optical coherence tomography for the diagnosis of superficial basal cell carcinoma: a prospective, consecutive, cohort study of 168 cases

      H.M. Cheng, S. Lo, R. Scolyer, A. Meekings, G. Carlos and P. Guitera

      Version of Record online: 24 SEP 2016 | DOI: 10.1111/bjd.14714

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      What's already known about this topic?

      • Optical coherence tomography (OCT) can be used for diagnosis and depth measurement of basal cell carcinoma (BCC).
      • OCT features of subtypes of basal cell carcinoma have been described.

      What does this study add?

      • The clinical diagnostic accuracy of sBCC can be increased by the use of OCT.
      • The depth of thin BCCs < 0·4 mm can be measured accurately using OCT.
      • There is good interobserver agreement for sBCC diagnosis by OCT when performed by experienced operators.
      • More research is necessary before it would be appropriate to recommend its use as a substitute for pathology in diagnosis and management.
  3. Case Reports

    1. Foreign body reaction triggered by cytotoxic T lymphocyte-associated protein 4 blockade 25 years after dermal filler injection

      C. Bisschop, M.S. Bruijn, M.W. Stenekes, G.F.H. Diercks and G.A.P. Hospers

      Version of Record online: 24 SEP 2016 | DOI: 10.1111/bjd.14674

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      What's already known about this topic?

      • Foreign body granuloma is regularly seen as a late complication of cosmetic treatment with synthetic dermal fillers.
      • Most often a severe systemic infection is the trigger of a foreign body reaction to dermal fillers. Autoimmune diseases and (immunostimulatory) drugs are known triggers.

      What does this study add?

      • Ipilimumab, an immune checkpoint inhibitor used as anticancer treatment, can cause a foreign body reaction to dermal filler treatment.
  4. General Dermatology

    1. Comparing preferences for outcomes of psoriasis treatments among patients and dermatologists in the U.K.: results from a discrete-choice experiment

      J.M. Gonzalez, F.R. Johnson, H. McAteer, J. Posner and F. Mughal

      Version of Record online: 24 SEP 2016 | DOI: 10.1111/bjd.14798

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      What's already known about this topic?

      • Plaque psoriasis is associated with a number of comorbidities and can have a significant negative effect on patients’ quality of life.
      • Systemic nonbiological and biological treatments for psoriasis can result in serious toxicities, including risks of serious infections and malignancies or lymphoma.

      What does this study add?

      • This study uses a discrete-choice experiment to elicit and contrast stated preferences for outcomes of psoriasis treatments from the perspective of patients with psoriasis and the dermatologists who treat them using a common instrument.
  5. Clinical Trials

    1. You have full text access to this OnlineOpen article
      Topical tofacitinib for atopic dermatitis: a phase IIa randomized trial

      R. Bissonnette, K.A. Papp, Y. Poulin, M. Gooderham, M. Raman, L. Mallbris, C. Wang, V. Purohit, C. Mamolo, J. Papacharalambous and W.C. Ports

      Version of Record online: 24 SEP 2016 | DOI: 10.1111/bjd.14871

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      What's already known about this topic?

      • Atopic dermatitis (AD) is a common, inflammatory skin condition affecting adults and children worldwide with prevalence rates of up to 20% and increasing.
      • Despite unmet medical need, it has been 15 years since a new AD drug with a novel mechanism of action has been approved, highlighting the need for other effective agents.
      • Recent clinical and nonclinical data support the potential therapeutic benefit of Janus kinase (JAK) inhibition in treating AD.

      What does this study add?

      • Tofacitinib ointment showed significantly greater efficacy vs. vehicle across all study end points, with early onset of effect, and comparable safety/local tolerability with vehicle.
      • JAK inhibition through topical delivery is potentially a promising treatment target for AD.
      • This study provides important information to the medical research community regarding AD treatment options that have a new mechanism of action.
  6. Letters to the Editor

    1. The cross-talk between renal function, inflammation and psoriasis vulgaris

      S. Coimbra, H. Oliveira, P. Rocha-Pereira, A. Figueiredo and A. Santos-Silva

      Version of Record online: 21 SEP 2016 | DOI: 10.1111/bjd.14913

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  7. Translational Research

    1. Dual c-Jun N-terminal kinase–cyclin D1 and extracellular signal-related kinase–c-Jun disjunction in human melanoma

      G. Pathria, B. Garg, K. Garg, C. Wagner and S.N. Wagner

      Version of Record online: 20 SEP 2016 | DOI: 10.1111/bjd.14713

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      What's already known about this topic?

      • BRAF targeting in BRAF-mutated melanomas fails to achieve a sustained therapeutic response.
      • Previous work has shown this to be partially associated with its inability to downregulate c-Jun expression and activity.
      • c-Jun N-terminal Kinase (JNK) signalling positively regulates c-Jun and its transcriptional target cyclin D1.

      What does this study add?

      • The current work demonstrates the requirement of JNK signalling in melanoma cell proliferation and survival.
      • JNK blockade, while successfully suppressing c-Jun expression/activity, fails to mitigate cyclin D1 levels.
      • MEK inhibition, although failing to suppress c-Jun expression/activity, successfully downregulated cyclin D1 levels.
      • This forms a further mechanistic basis for evaluating dual JNK/MEK–ERK signalling inhibition in BRAF-mutated melanomas.

      What is the translational message?

      • MAPK (MEK–ERK) and JNK signalling pathway inhibition, paradoxically, fails to suppress c-Jun and cyclin D1, respectively.
      • Suppression of c-Jun and cyclin D1 upon JNK and MEK–ERK pathway inhibition, respectively, seems intact in melanoma cells.
      • Together these observations purport concomitant MEK–ERK and JNK signalling pathway blockade as a potential therapeutic strategy in human melanoma.
  8. Research Letters

    1. Oral nicotinamide reduces transepidermal water loss: a randomized controlled trial

      A.C. Chen, A.J. Martin, R.A. Dalziell, G.M. Halliday and D.L. Damian

      Version of Record online: 20 SEP 2016 | DOI: 10.1111/bjd.14648

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    2. Ivermectin cream improves health-related quality of life in patients with rosacea: data from a randomized trial

      A. Taieb, T. Passeron, T. Ruzicka, J. Berth-Jones, J. Jacovella, M.Y. Huang and A. Wertheimer

      Version of Record online: 19 SEP 2016 | DOI: 10.1111/bjd.14665

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  9. Translational Research

    1. An exploratory study investigating the metabolic activity and local cytokine profile in patients with melanoma treated with pazopanib and paclitaxel

      S. Thurneysen, P.F. Cheng, H.W. Nagel, M. Kunz, N. Jaberg-Bentele, M. Nägeli, M. Ziegler, E. Guenova, S.M. Goldinger, J. Mangana, M.P. Levesque and R. Dummer

      Version of Record online: 19 SEP 2016 | DOI: 10.1111/bjd.14727

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      What's already known about this topic?

      • Increased expression of vascular endothelial growth factor (VEGF) and other tyrosine kinases leads to tumour promotion, associated with poor prognosis in patients with melanoma.
      • Pazopanib is a multitarget tyrosine kinase inhibitor effective in several tumour types.
      • Pazopanib is suggested to suppress VEGF effects and has shown some efficacy in melanoma.

      What does this study add?

      • Pazopanib showed limited activity in patients with advanced melanoma.
      • Responding tumours demonstrated high expression of several chemokines and cytokines.
      • Resistant tumours showed high numbers of tumour-associated M2-like macrophages.

      What is the translational message?

      • Systemic therapy with the multikinase inhibitor pazopanib results in profound alterations of the microenvironment in metastatic melanoma, including the cytokine–chemokine network.
      • A primary effect is documented on tumour-associated macrophages, which might protect the tumour cell population from pazopanib-induced growth inhibition and cell death.
    2. Therapeutic drug monitoring of patients with psoriasis during tumour necrosis factor (TNF)-α antagonist treatment using a novel interleukin-8 reporter cell line

      Y. Kimura, R. Shimada-Omori, T. Takahashi, K. Tsuchiyama, Y. Kusakari, K. Yamasaki, R. Nishikawa, C. Nishigori and S. Aiba

      Version of Record online: 19 SEP 2016 | DOI: 10.1111/bjd.14717

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      What's already known about this topic?

      • Tumour necrosis factor (TNF)-α antagonist therapy has several drawbacks including secondary loss of effectiveness.

      What does this study add?

      • The percentage suppression of patients’ plasma determined by an interleukin-8 reporter cell line can estimate the efficacy of TNF-α antagonists with higher specificity and sensitivity than the trough level.
      • This measure can be a useful tool to overcome the drawbacks of TNF-α antagonist therapy.

      What is the translational message?

      • We report therapeutic drug monitoring of patients with psoriasis during TNF-α antagonist treatment using a novel interleukin-8 reporter cell line.
      • Such monitoring enables early detection of secondary loss of response to TNF-α antagonists and reduction of their ineffective use.
  10. Research Letters

  11. Letters to the Editor

  12. Qualitative Research

    1. You have full text access to this OnlineOpen article
      The importance of mindfulness in psychosocial distress and quality of life in dermatology patients

      K. Montgomery, P. Norman, A.G. Messenger and A.R. Thompson

      Version of Record online: 18 SEP 2016 | DOI: 10.1111/bjd.14719

      What's already known about this topic?

      • Correlation studies suggest that higher levels of mindfulness are related to lower levels of social anxiety.
      • Studies indicate that mindfulness can be beneficial for people experiencing a range of long-term health conditions.
      • Mindfulness interventions have been beneficial in improving skin clearance and severity in patients with psoriasis.

      What does this study add?

      • This is the first study to show that mindfulness accounts for a significant amount of the variance in both psychological distress and quality of life in dermatology patients.
      • Mindfulness may play a particularly important role in social anxiety.
      • The study suggests that facilitating the ‘ability to attend to the present moment’ is a potential target for psychosocial interventions for patients distressed by their skin condition.

      What are the clinical implications of this work?

      • High levels of social anxiety, depression and anxiety highlight the need for psychological interventions to be available to dermatology patients.
      • Mindfulness interventions could benefit people living with skin conditions who are experiencing psychological distress – either as stand-alone low-intensity interventions or incorporated into cognitive behavioural therapy.
      • Using mindfulness to bring attention to the present moment may reduce self-focused attention, which is a key characteristic of social anxiety.
  13. Research Letters

    1. Disturbed postprandial glucose metabolism and gut hormone responses in non-diabetic patients with psoriasis

      M. Gyldenløve, T. Vilsbøll, J.J. Holst, C. Zachariae, L. Skov and F.K. Knop

      Version of Record online: 14 SEP 2016 | DOI: 10.1111/bjd.13789

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  14. Letters to the Editor

    1. BASCULE syndrome: old wine in new bottles?

      D.H. McGibbon

      Version of Record online: 14 SEP 2016 | DOI: 10.1111/bjd.14898

  15. Translational Research

    1. The prognostic significance and impact of the CXCR4–CXCR7–CXCL12 axis in primary cutaneous melanoma

      A.T. McConnell, R. Ellis, B. Pathy, R. Plummer, P.E. Lovat and G. O'Boyle

      Version of Record online: 13 SEP 2016 | DOI: 10.1111/bjd.14720

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      What's already known about this topic?

      • CXCR4 expression is associated with poor prognostic indicators including tumour ulceration, thickness and metastasis.
      • Expression of CXCR4 is crucial in regulating melanoma chemotaxis to distant secondary sites of metastasis with high expression of the ligand, CXCL12.
      • Previous studies suggest a lack of correlation between melanoma CXCL12 expression and disease progression or BRAF mutational status.
      • CXCR7 is an atypical/decoy CXCL12 receptor that may act to shape CXCL12 gradients.

      What does this study add?

      • Elevated CXCR4 expression is a prognostic biomarker for AJCC stage II primary melanomas.
      • Autocrine melanoma CXCR4–CXCL12 signalling promotes hyperactivation of prosurvival MAPK signalling.
      • CXCL12 expression by stromal cells in the primary melanoma microenvironment protects from metastasis potentially by retaining tumour cells within the cutaneous microenvironment.
      • Downregulation of melanoma CXCL12 is associated with an aggressive BRAF/NRAS mutant phenotype.
      • CXCR7 expression by cutaneous vascular endothelium and not primary melanomas suggests a mechanism mediating tumour intravasation.

      What is the translational message?

      • CXCR4 expression defines a potential candidate biomarker for melanoma providing additional prognostic information to AJCC disease staging and a means of identifying high-risk patient subgroups.
      • The reported role of CXCR4–CXCR7–CXCL12 chemokine signalling within the primary cutaneous melanoma microenvironment highlights the potential for targeting this chemokine axis to prevent the development of metastatic disease.
  16. Surgical Dermatology

    1. Improving the applicability of guidelines on nonmelanoma skin cancer in frail older adults: a multidisciplinary expert consensus and systematic review of current guidelines

      S.F.K. Lubeek, R.J. Borgonjen, L.J. van Vugt, M.G. Olde Rikkert, P.C.M. van de Kerkhof and M.J.P. Gerritsen

      Version of Record online: 13 SEP 2016 | DOI: 10.1111/bjd.14923

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      What's already known about this topic?

      • Nonmelanoma skin cancer is common among the growing population of frail older adults worldwide.
      • Treatment decisions in frail older adults with nonmelanoma skin cancer can be challenging.
      • Clinical practice guidelines are intended to assist healthcare providers to optimize patient care in daily clinical practice, but balancing the extensiveness and specificity of clinical practice guidelines might be a challenge.

      What does this study add?

      • More attention to several frailty-related items in clinical practice guidelines on nonmelanoma skin cancer is broadly desired.
      • Integration of these items into current clinical practice guidelines on nonmelanoma skin cancer is limited.
      • More integration is expected to optimize current nonmelanoma skin cancer care and might stimulate more holistic, personalized and patient-centred care in frail older adults.
  17. Research Letters

    1. Cumulative mental health consequences of acne: 23-year follow-up in a general population birth cohort study

      S. Ramrakha, D.M. Fergusson, L.J. Horwood, F. Dalgard, A. Ambler, J. Kokaua, B.J. Milne and R. Poulton

      Version of Record online: 13 SEP 2016 | DOI: 10.1111/bjd.13786

  18. Letters to the Editor

  19. Translational Research

    1. Summary of results of serological tests and diagnoses for 4774 cases of various autoimmune bullous diseases consulted to Kurume University

      T. Hashimoto, D. Tsuruta, H. Koga, S. Fukuda, B. Ohyama, A. Komai, T. Karashima, C. Ohata, K. Teye and N. Ishii

      Version of Record online: 11 SEP 2016 | DOI: 10.1111/bjd.14692

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      What's already known about this topic?

      • There are many different autoimmune bullous diseases (AIBDs) that are diagnosed by immunological tests, in addition to clinical and histopathological examinations.
      • As one of the centres for diagnosis of AIBDs in Japan, we have collected sera and information for more than 5000 difficult cases of various AIBDs over the last 19 years, and have performed various serological tests.

      What does this study add?

      • This study presents the current classification and algorithm for immunological diagnosis in AIBDs.
      • This study also presents the final diagnoses for our 4774 patients with AIBDs, which were made by our immunological diagnostic method.

      What is the translational message?

      • This study proposes a comprehensive novel classification of AIBDs, which should be useful for precise and detailed diagnoses of various AIBDs in the clinical field.
      • The large number of immunological and molecular methods described in this study should also facilitate clinical practice, such as for diagnoses and appropriate selection of treatments, for various AIBDs.
  20. General Dermatology

    1. Invasive melanoma in vivo can be distinguished from basal cell carcinoma, benign naevi and healthy skin by canine olfaction: a proof-of-principle study of differential volatile organic compound emission

      C.M. Willis, L.E. Britton, M.A. Swindells, E.M. Jones, A.E. Kemp, N.L. Muirhead, A. Gul, R.N. Matin, L. Knutsson and M. Ali

      Version of Record online: 11 SEP 2016 | DOI: 10.1111/bjd.14887

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      What's already known about this topic?

      • Some tumours have been shown to emit characteristic patterns of volatile organic compounds (VOCs).
      • There is anecdotal evidence of canine olfactory detection of melanoma, and some supporting analytical findings, but robust data for a distinct profile of melanoma-associated VOCs are lacking.

      What does this study add?

      • We demonstrated by canine olfaction that invasive melanoma in vivo emits a profile of odorous VOCs that differs from those of basal cell carcinoma, benign naevi and healthy skin.
      • The study provides further evidence of the potential for VOCs to be utilized as biomarkers for the objective, noninvasive diagnosis of melanoma.
  21. Letters to the Editor

  22. Medical Dermatology

    1. Overlap between maculopapular exanthema and drug reaction with eosinophilia and systemic symptoms among cutaneous adverse drug reactions in a dermatology ward

      M. Pinto Gouveia, A. Gameiro, I. Coutinho, N. Pereira, J.C. Cardoso and M. Gonçalo

      Version of Record online: 6 SEP 2016 | DOI: 10.1111/bjd.14704

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      What's already known about this topic?

      • Clinical patterns of nonimmediate cutaneous adverse drug reactions are well characterized, namely drug reaction with eosinophilia and systemic symptoms (DRESS), Stevens–Johnson syndrome/toxic epidermal necrolysis, acute generalized exanthematous pustulosis and maculopapular exanthema (MPE).
      • Occasional overlapping clinical patterns have been described.

      What does this study add?

      • We characterized an overlapping pattern between MPE and DRESS, with exanthema and less systemic involvement than DRESS.
      • Culprit drugs and affected organs were similar but with a reduced latency period and duration of the reaction, suggesting a minor form of DRESS.
  23. Epidemiology

    1. Effects of the German skin cancer screening programme on melanoma incidence and indicators of disease severity

      F. Trautmann, F. Meier, A. Seidler and J. Schmitt

      Version of Record online: 6 SEP 2016 | DOI: 10.1111/bjd.14758

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      What's already known about this topic?

      • Evidence on the utilization and effects of the German nationwide screening programme for melanoma introduced in 2008 is limited.

      What does this study add?

      • The annual participation rate was 12·4% among all eligible persons (age ≥ 35 years).
      • No significant increase in melanoma incidence was found after introduction of the screening programme.
      • Fewer patients with melanoma within the screening programme were diagnosed with metastasis and/or received interferon alpha treatment compared with patients never participating in the programme.
  24. General Dermatology

    1. Consumer acceptance of patient-performed mobile teledermoscopy for the early detection of melanoma

      C. Horsham, L.J. Loescher, D.C. Whiteman, H.P. Soyer and M. Janda

      Version of Record online: 2 SEP 2016 | DOI: 10.1111/bjd.14630

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      What's already known about this topic?

      • Cancer Councils recommend that patients conduct regular skin self-examinations for the early detection of melanoma.
      • Patient-initiated, self-performed mobile teledermoscopy may aid consumers in this process.

      What does this study add?

      • Older adults at high risk of melanoma are highly accepting of mobile teledermoscopy. However, complete trust in the telediagnosis was a concern among some participants.
      • Most participants found mobile teledermoscopy easy to conduct.
  25. Translational Research

    1. Identification of LCK mutation in a family with atypical epidermodysplasia verruciformis with T-cell defects and virus-induced squamous cell carcinoma

      S.-L. Li, L.-N. Duo, H.-J. Wang, W. Dai, E.-Y.H. Zhou, Y.-N. Xu, T. Zhao, Y.-Y. Xiao, L. Xia, Z.-H. Yang, L.-T. Zheng, Y.-Y. Hu, Z.-M. Lin, H.-N. Wang, T.-W. Gao, C.-L. Ma, Y. Yang and C.-Y. Li

      Version of Record online: 31 AUG 2016 | DOI: 10.1111/bjd.14679

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      What's already known about this topic?

      • Epidermodysplasia verruciformis (EV) is an unusual genodermatosis characterized by an increased susceptibility to β-human papillomavirus and is associated with a high risk of skin carcinoma.
      • Inactivating mutations in EVER1/EVER2 account for most cases of EV.

      What does this study add?

      • Our study suggests an association between a novel splicing mutation in LCK and EV susceptibility.

      What is the translational message?

      • Patients with EV should be tested for T lymphocyte-specific protein tyrosine kinase deficiency and T-cell function, which will help guide treatment.
  26. General Dermatology

    1. Genetic susceptibility to cutaneous melanoma in southern Switzerland: role of CDKN2A, MC1R and MITF

      C. Mangas, M. Potrony, C. Mainetti, E. Bianchi, P. Carrozza Merlani, A. Mancarella Eberhardt, E. Maspoli-Postizzi, G. Marazza, A. Marcollo-Pini, F. Pelloni, C. Sessa, B. Simona, J.A. Puig-Butillé, C. Badenas and S. Puig

      Version of Record online: 31 AUG 2016 | DOI: 10.1111/bjd.14897

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      What's already known about this topic?

      • CDKN2A as a high-penetrance risk factor and MITF and MCR1, with low-to-intermediate penetrance, are the most important genes involved in melanoma susceptibility.
      • Mutation detection rates in these genes are highly variable across regions.
      • CDKN2A mutation detection increases with the number of melanomas, young age at diagnosis and concomitant pancreatic cancer in the family.

      What does this study add?

      • The genetic predisposition to melanoma in southern Switzerland is analysed for the first time.
      • A CDKN2A high-risk mutation is detected in almost 10% of pedigrees and MITF p.E318K mutation in 7%.
      • It is difficult to establish a rule for recommending genetic testing based on only the number of melanomas in the family or the individual.
  27. Translational Research

    1. You have full text access to this OnlineOpen article
      Differences in telomere length between sporadic and familial cutaneous melanoma

      C. Menin, E. Bojnik, P. Del Bianco, L. Elefanti, K. Gianesin, S. Keppel, C. Stagni, S. Mocellin, A. Vecchiato and A. De Rossi

      Version of Record online: 31 AUG 2016 | DOI: 10.1111/bjd.14652

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      What's already known about this topic?

      • The role of telomere biology in tumorigenesis is complex and influenced by multiple mechanisms, even acting in opposite directions.

      What does this study add?

      • Constitutive telomere length is significantly different between familial and sporadic melanoma.
      • Short telomeres increase the risk of single sporadic melanoma, but decrease that of familial melanoma.

      What is the translational message?

      • Individual susceptibility to cancer should be taken into account when assessing the role of telomere length as a cancer risk factor.
  28. Research Letters

    1. Ichthyosis as the dermatological phenotype associated with TTC7A mutations

      S. Leclerc-Mercier, R. Lemoine, A.E. Bigorgne, F. Sepulveda, C. Leveau, A. Fischer, N. Mahlaoui, S. Hadj-Rabia and G. de Saint Basile

      Version of Record online: 31 AUG 2016 | DOI: 10.1111/bjd.14644

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  29. Scholarly Reviews

    1. Treatment of clinically amyopathic dermatomyositis in adults: a systematic review

      J. Callander, Y. Robson, J. Ingram and V. Piguet

      Version of Record online: 30 AUG 2016 | DOI: 10.1111/bjd.14726

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      What's already known about this topic?

      • Clinically amyopathic dermatomyositis (CADM) is defined as the presence of cutaneous signs of dermatomyositis with no clinical evidence of muscle weakness for ≥ 6 months.
      • CADM affects 5–20% of patients with dermatomyositis and has a significant impact on quality of life.
      • There is no current consensus on the treatment of CADM and no previous systematic reviews have assessed this.

      What does this study add?

      • This systematic review has established that there are no randomized controlled trials or robust observational studies for treatment of CADM.
      • From the compilation of case series and reports, hydroxychloroquine is the most commonly prescribed treatment for CADM.
      • A proportion of patients have treatment-resistant disease.
      • In comparison with other treatments, intravenous immunoglobulin led to improvement or remission in the highest proportion of patients included in our review.
  30. Medical Dermatology

    1. Diagnostic value of immunohistochemistry on formalin-fixed, paraffin-embedded skin biopsy specimens for bullous pemphigoid

      S. Glauser, M. Rutz, S. Cazzaniga, I. Hegyi, L. Borradori and H. Beltraminelli

      Version of Record online: 30 AUG 2016 | DOI: 10.1111/bjd.14686

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      What's already known about this topic?

      • Direct immunofluorescence microscopy (DIF) studies represent the gold standard for the diagnosis of bullous pemphigoid (BP).
      • Recent studies have reported that immunohistochemistry techniques using formalin-fixed, paraffin-embedded skin biopsy specimens are able to detect tissue-bound immunoreactants in BP with high sensitivity and thus constitute an alternative and practical diagnostic tool.

      What does this study add?

      • Immunohistochemical analyses are not sensitive enough to recommend their use for the diagnosis of BP, as < 50% of 51 consecutive paraffin-embedded skin biopsy specimens obtained from patients with newly diagnosed BP were positive.
      • If DIF cannot be performed, immunohistochemistry represents a useful diagnostic tool only in the presence of histologically subepidermal blistering and/or with positive immunoserological tests, which are associated with a better sensitivity.
  31. Translational Research

    1. A potential contribution of antimicrobial peptide LL-37 to tissue fibrosis and vasculopathy in systemic sclerosis

      T. Takahashi, Y. Asano, K. Nakamura, T. Yamashita, R. Saigusa, Y. Ichimura, T. Toyama, T. Taniguchi, A. Yoshizaki, Z. Tamaki, Y. Tada, M. Sugaya, T. Kadono and S. Sato

      Version of Record online: 30 AUG 2016 | DOI: 10.1111/bjd.14699

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      What's already known about this topic?

      • LL-37, an antimicrobial peptide, has been shown to be upregulated in systemic sclerosis dermal fibroblasts.
      • LL-37 potentially contributes to dermal fibrosis through its antiapoptotic effect on those cells.

      What does this study add?

      • LL-37 potentially contributes to the development of skin sclerosis, interstitial lung disease and digital ulcers in systemic sclerosis.
      • This further supports the critical role of antimicrobial peptides in the development of autoimmune and inflammatory diseases.

      What is the translational message?

      • LL-37 induction due to Fli1 deficiency in endothelial cells supports the notion that Fli1 deficiency is a key predisposing factor in the pathogenesis of systemic sclerosis.
      • This has recently been demonstrated by the establishment of a new systemic sclerosis animal model, with mice double heterozygous for the Klf5 and Fli1 genes.
  32. Research Letters

    1. Brain inflammation and psoriasis: a [11C]-(R)-PK11195 positron emission tomography study

      H.J.A. Hunter, R. Hinz, A. Gerhard, P.S. Talbot, Z. Su, G. Holland, S.J. Hopkins, C.E.M. Griffiths and C.E. Kleyn

      Version of Record online: 30 AUG 2016 | DOI: 10.1111/bjd.13788

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  33. Letters to the Editor

    1. Isolated cutaneous leiomyosarcoma revealing a novel germline mutation of the fumarate hydratase gene

      L. Weiler, N. Poulalhon, A. Slama, M. Guillaud-Bataille and L. Thomas

      Version of Record online: 30 AUG 2016 | DOI: 10.1111/bjd.13867

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  34. Systematic Reviews

    1. You have full text access to this OnlineOpen article
      Oral fumaric acid esters for psoriasis: abridged Cochrane systematic review including GRADE assessments

      A. Atwan, J.R. Ingram, R. Abbott, M.J. Kelson, T. Pickles, A. Bauer and V. Piguet

      Version of Record online: 29 AUG 2016 | DOI: 10.1111/bjd.14676

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      What's already known about this topic?

      • Fumaric acid esters (FAEs) are licensed for the treatment of moderate-to-severe psoriasis in Germany, and are used off-label in many other countries.
      • Non-Cochrane systematic reviews previously examined the effect of FAEs in psoriasis, but have not rigorously assessed the quality of the evidence.

      What does this study add?

      • Six randomized controlled trials with 544 participants were included, four of which were published only as abstracts or brief reports, resulting in low- or very low-quality evidence.
      • Results suggest that FAEs are superior to placebo, but their efficacy in comparison with methotrexate is uncertain due to very low-quality evidence.
      • The relative risk of nuisance adverse effects with FAEs is about five times greater than with placebo; however, there is insufficient evidence available to give an accurate figure for dropout rates due to adverse effects.
  35. Medical Dermatology

    1. In vitro test to confirm diagnosis of allopurinol-induced severe cutaneous adverse reactions

      J. Klaewsongkram, P. Thantiworasit, N. Suthumchai, P. Rerknimitr, C. Sukasem, P. Tuchinda, L. Chularojanamontri, Y. Srinoulprasert, T. Rerkpattanapipat, K. Chanprapaph, W. Disphanurat, P. Chakkavittumrong, N. Tovanabutra and C. Srisuttiyakorn

      Version of Record online: 29 AUG 2016 | DOI: 10.1111/bjd.14701

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      What's already known about this topic?

      • Allopurinol is among the most common drugs causing severe cutaneous adverse reactions worldwide.
      • The skin tests and in vitro assays currently available exhibit low sensitivity in verifying the diagnosis of allopurinol hypersensitivity in suspected cases.

      What does this study add?

      • This is the first study to introduce an in vitro test, demonstrating high diagnostic value in confirming the diagnosis of allopurinol-induced severe cutaneous adverse reactions.
  36. Epidemiology

    1. Association between atopic dermatitis and attention deficit hyperactivity disorder in U.S. children and adults

      M.A. Strom, A.B. Fishbein, A.S. Paller and J.I. Silverberg

      Version of Record online: 28 AUG 2016 | DOI: 10.1111/bjd.14697

      What's already known about this topic?

      • Childhood atopic dermatitis (AD) is associated with increased risk of attention deficit hyperactivity disorder (ADHD); sleep disturbance and disease severity have been implicated as modifying factors.

      What does this study add?

      • Severe AD and sleep disturbance independently and synergistically contribute to increased risk of ADHD.
      • AD unaccompanied by other allergic diseases is associated with increased risk of attention deficit disorder (ADD)/ADHD.
      • Obesity, headaches and anaemia further increase the risk of ADD/ADHD in children with AD.
      • Adult AD is associated with increased risk of ADHD. Asthma, headaches and insomnia increase the risk of ADHD in adult patients with AD, and underweight body mass index is protective.
  37. Translational Research

    1. Longitudinal analysis of antibody profiles against plakins in severe drug eruptions: emphasis on correlation with tissue damage in drug-induced hypersensitivity syndrome and drug reaction with eosinophilia and systemic symptoms

      A. Takehara, Y. Aoyama, M. Kurosawa, Y. Shirafuji, H. Umemura, K. Kamiya, Y. Ushigome, Y. Kano, T. Shiohara and K. Iwatsuki

      Version of Record online: 28 AUG 2016 | DOI: 10.1111/bjd.14677

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      What's already known about this topic?

      • Evidence for severe drug eruption as a trigger for autoimmune diseases has increased.
      • Sera from patients with Stevens–Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) have been shown to contain autoantibodies (autoAbs) against epidermal proteins generated as a consequence of epidermal damage.
      • No information is available about the existence of these autoAbs in drug-induced hypersensitivity syndrome (DiHS)/drug reaction with eosinophilia and systemic symptoms (DRESS), characterized by lack of epidermal damage and gradual loss of regulatory T-cell function.

      What does this study add?

      • These autoAbs were more persistently and frequently detected in patients with DiHS/DRESS than in SJS/TEN.
      • In DiHS/DRESS, liver damage during the early and acute phases, together with a regulatory T-cell dysfunction, would serve to generate autoAbs.

      What is the translational message?

      • Patients with severe drug eruptions benefit from corticosteroid therapy during the acute stage with regard to the subsequent development of autoimmune responses.
      • Achievement of early resolution by corticosteroids is associated with a lower risk of subsequently developing autoimmune responses, particularly in patients with DiHS/DRESS.
      • The need to relieve clinical symptoms by corticosteroids should be balanced with antimicrobial therapies aiming at reducing the risk of infectious diseases.
  38. Review Articles

    1. Pyoderma gangrenosum and its syndromic forms: evidence for a link with autoinflammation

      A.V. Marzano, A. Borghi, P.L. Meroni and M. Cugno

      Version of Record online: 23 AUG 2016 | DOI: 10.1111/bjd.14691

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      What's already known about this topic?

      • Pyoderma gangrenosum is a rare neutrophilic dermatosis usually manifesting as painful ulcers with violaceous, raised and undermined borders on the legs.
      • It presents alone or in the context of syndromic forms like PAPA (pyogenic arthritis, pyoderma gangrenosum and acne), PASH (pyoderma gangrenosum, acne and suppurative hidradenitis) and SAPHO (synovitis, acne, pustulosis, hyperostosis, osteitis).

      What does this study add?

      • Pyoderma gangrenosum and its syndromes have a peculiar immunological profile suggesting autoinflammation.
      • Interleukin (IL)-1β is crucial in the pathophysiology of autoinflammatory/neutrophilic dermatoses, and its cross-talk with IL-17 may contribute to neutrophil recruitment and activation.
      • IL-1 blockade represents the most selective treatment for pyoderma and its syndromes, but, in the future, IL-17 antagonists could also be considered.
  39. Research Letters

    1. Randomized trials in top dermatological journals, 2009–13

      D. Romero-Pérez, J.M. Ramos, B. Encabo and I. Belinchón

      Version of Record online: 23 AUG 2016 | DOI: 10.1111/bjd.14329

  40. General Dermatology

    1. A functional mechanistic study of the effect of emollients on the structure and function of the skin barrier

      S.G. Danby, J. Chalmers, K. Brown, H.C. Williams and M.J. Cork

      Version of Record online: 23 AUG 2016 | DOI: 10.1111/bjd.14684

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      What's already known about this topic?

      • A skin barrier defect is a primary event in the development of atopic dermatitis (AD).
      • Topical therapy to correct this skin barrier defect may prevent AD relapses.
      • Not all emollients exert a positive effect on the skin barrier. The use of aqueous cream BP, for example, damages the skin barrier.

      What does this study add?

      • We provide evidence that, in contrast to aqueous cream BP, two commonly prescribed emollients exert no negative effects on the skin barrier, and are therefore suitable for further clinical testing in AD prevention trials.
      • We also highlight that while these ancillary treatments display clinically important ‘emollient’ properties they do little to actively improve skin barrier function.
  41. Letters to the Editor

    1. Causative drug detection by drug-induced lymphocyte stimulation test in drug-induced linear IgA bullous dermatosis

      E. Tomida, Y. Kato, H. Ozawa, H. Hasegawa, N. Ishii, T. Hashimoto and M. Akiyama

      Version of Record online: 23 AUG 2016 | DOI: 10.1111/bjd.14069

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  42. Review Articles

    1. The many faces of interleukin-17 in inflammatory skin diseases

      R. Speeckaert, J. Lambert, L. Grine, M. Van Gele, S. De Schepper and N. van Geel

      Version of Record online: 23 AUG 2016 | DOI: 10.1111/bjd.14703

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      What's already known about this topic?

      • Anti-interleukin (anti-IL)-17 treatment shows dramatic responses in patients with psoriasis.
      • The pathogenic involvement of IL-17 also becomes clear in several other inflammatory skin disorders.

      What does this study add?

      • In this review, we provide an overview of the current understanding of the IL-17 pathway in immune-regulated skin diseases.
      • This delineates the group of disorders that are likely to respond.
  43. Research Letters

    1. Ulcerated infantile haemangiomas: the effect of the selective beta-blocker atenolol on wound healing

      G. Ruitenberg, D.A. Young-Afat, M. de Graaf, S.G.M.A. Pasmans and C.C. Breugem

      Version of Record online: 19 AUG 2016 | DOI: 10.1111/bjd.14687

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  44. Case Reports

    1. Linear porokeratosis with multiple squamous cell carcinomas successfully treated by electrochemotherapy

      M. Sommerlad, A. Lock, G. Moir, J. McGregor, R. Bull, R. Cerio and C. Harwood

      Version of Record online: 17 AUG 2016 | DOI: 10.1111/bjd.14669

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      What's already known about this topic?

      • Linear porokeratosis is a rare variant of porokeratosis thought to represent a mosaic form of disseminated superficial porokeratosis.
      • The diagnosis may be difficult to make. Patients are often initially diagnosed with variants of psoriasis or epidermal naevi.
      • Linear porokeratosis has the highest rate of malignant transformation. Treatment can be challenging due to the multiplicity and location of tumours.

      What does this study add?

      • This is the first report of multiple squamous cell carcinomas in the context of linear porokeratosis being successfully treated with electrochemotherapy (ECT).
      • ECT resulted in significant and sustained clearance of linear porokeratosis.
      • We illustrate the importance of multidisciplinary team input in the diagnosis and management of systematized linear porokeratosis.
  45. Research Letters

    1. Lysyl oxidase-like 2 promoter hypermethylation in mid-dermal elastolysis

      T. Gambichler, M. Skrygan, L. Reininghaus, H.-J. Schulze, J. Schaller, S. Hessam, C. Colato, G. Girolomoni and E. Heitzer

      Version of Record online: 17 AUG 2016 | DOI: 10.1111/bjd.14666

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    2. Treatment of pyoderma gangrenosum: retrospective multicentre analysis of 121 patients

      K. Herberger, J. Dissemond, K. Hohaus, J. Schaller, Z. Anastasiadou and M. Augustin

      Version of Record online: 11 AUG 2016 | DOI: 10.1111/bjd.14619

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  46. Letters to the Editor

    1. Pilonidal sinus: clinical and ultrasonographic response to topical resorcinol 15%

      B. Encabo, J.C. Pascual, D. Romero, R.F. Ruiz de Apodaca, J. Selva and G.B.E. Jemec

      Version of Record online: 11 AUG 2016 | DOI: 10.1111/bjd.14872

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  47. Case Reports

    1. Nodules behind the ears: IgG4-related skin disease

      M. Kondo, S. Yamamoto, H. Goto and Y. Nara

      Version of Record online: 11 AUG 2016 | DOI: 10.1111/bjd.14628

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      What's already known about this topic?

      • IgG4-related disease is a recently recognized chronic fibrotic inflammation. Therefore, the phenomenon was suspected to be caused by continuous stimulation.

      What does this study add?

      • Our case shows that IgG4-related skin diseases may result from continuous sensitization to zinc and/or manganese.
  48. Research Letters

    1. Risk assessment of drug-induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome: a disproportionality analysis using the French Pharmacovigilance Database

      M.S. Agier, N. Boivin, A. Maruani, B. Giraudeau, A. Gouraud, F. Haramburu, M.J. Jean Pastor, L. Machet and A.P. Jonville-Bera

      Version of Record online: 11 AUG 2016 | DOI: 10.1111/bjd.14649

  49. Case Reports

    1. Late-onset cutaneous porphyria in a patient heterozygous for a uroporphyrinogen III synthase gene mutation

      P. Aguilera, C. Badenas, S.D. Whatley and J. To-Figueras

      Version of Record online: 11 AUG 2016 | DOI: 10.1111/bjd.14675

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      What's already known about this topic?

      • Congenital erythropoietic porphyria (CEP) is an autosomal recessive disease due to the inheritance of mutations within the uroporphyrinogen III synthase (UROS) gene.
      • Heterozygous carriers do not present clinical or biochemical involvement.
      • Rare patients without UROS mutations have presented a CEP-like phenotype associated with myelodysplasia.

      What does this study add?

      • We report a unique case of a patient with late-onset cutaneous porphyria who was found to be a CEP carrier.
      • He presented a heterozygous germline mutation (C73R/wild-type) and sustained overproduction of type I porphyrin isomers.
      • With no evidence of myelodysplasia, acquired mosaicism is hypothesized as the origin of the atypical phenotype.
  50. Research Letters

    1. Written treatment plans in atopic eczema management in children

      C. Duhovic, M. Mohsin, E. Duarte-Williamson and S. Baron

      Version of Record online: 11 AUG 2016 | DOI: 10.1111/bjd.14651

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    2. Clinical scores of sleep loss and itch, and antihistamine and topical corticosteroid usage for childhood eczema

      K.L. Hon, J.S.C. Kung, M. Wang, N.H. Pong, A.M. Li and T.F. Leung

      Version of Record online: 10 AUG 2016 | DOI: 10.1111/bjd.14660

    3. A phase II randomized controlled trial of nicotinamide for skin cancer chemoprevention in renal transplant recipients

      A.C. Chen, A.J. Martin, R.A. Dalziell, C.A. McKenzie, P.M. Lowe, J.M. Eris, R.A. Scolyer, H.M. Dhillon, J.L. Vardy, V.A. Bielski, G.M. Halliday and D.L. Damian

      Version of Record online: 10 AUG 2016 | DOI: 10.1111/bjd.14662

  51. Letters to the Editor

    1. Increased total serum IgE levels in moderate-to-severe hidradenitis suppurativa

      J.C. Pascual, F.J. García-Martínez, A. Martorell, I. González and P. Hispan

      Version of Record online: 10 AUG 2016 | DOI: 10.1111/bjd.14870

  52. Research Letters

    1. Rebound pustular psoriasis after brodalumab discontinuation

      A. Khemis, M. Cavalié, H. Montaudié, J.-P. Lacour and T. Passeron

      Version of Record online: 9 AUG 2016 | DOI: 10.1111/bjd.14627

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  53. Scholarly Reviews

    1. Current perspective on actinic keratosis: a review

      J.A. Siegel, K. Korgavkar and M.A. Weinstock

      Version of Record online: 8 AUG 2016 | DOI: 10.1111/bjd.14852

      What's already known about this topic?

      • Actinic keratoses (AKs) are a major public health concern because of their high prevalence, substantial cost and potential for progression to keratinocyte carcinoma, particularly squamous cell carcinoma.

      What does this study add?

      • Improved agreement among healthcare practitioners on AK definition and classification is needed to improve management.
      • More head-to-head comparisons of alternative treatment strategies for AK are needed to determine the best treatment.
  54. Letters to the Editor

    1. Isolated eyebrow loss in frontal fibrosing alopecia: relevance of early diagnosis and treatment

      A. Anzai, A. Donati, N.Y.S. Valente, R. Romiti and A. Tosti

      Version of Record online: 31 JUL 2016 | DOI: 10.1111/bjd.14750

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  55. Research Letters

    1. Incontinentia pigmenti in a father and daughter

      E. Rashidghamat, C.K. Hsu, A. Nanda, L. Liu, H. Al-Ajmi and J.A. McGrath

      Version of Record online: 24 JUL 2016 | DOI: 10.1111/bjd.14615

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  56. Case Reports

    1. In vivo reflectance confocal microscopy characterization of silver deposits in localized cutaneous argyria

      P. García-Martínez, D. López Aventín, S. Segura, I. Gómez-Martín, J. Lloreta, J. Ibáñez, J.J. Elvira and R.M. Pujol

      Version of Record online: 5 JUL 2016 | DOI: 10.1111/bjd.14571

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    2. Worsening of calcinosis cutis with teriparatide treatment in two osteoporotic patients

      A.F. Echeverri, F.E. Ospina, C.A. Cañas, A. Agualimpia, J.P. Suso, G.J. Tobón and F. Bonilla-Abadía

      Version of Record online: 20 JUN 2016 | DOI: 10.1111/bjd.14550

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      What's already known about this topic?

      • After searching the literature with the medical subject heading terms ‘calcinosis cutis’, ‘teriparatide’ and ‘complications’, we found no known literature on this topic.

      What does this study add?

      • We report two cases of systemic autoimmune disease with concomitant calcinosis cutis that worsened on treatment with teriparatide.
      • We alert practitioners to the possible side-effects of teriparatide in patients with dermatomyositis and CREST syndrome who have calcinosis cutis.
  57. Scholarly Reviews

    1. Pyoderma gangrenosum and Sweet syndrome: the prototypic neutrophilic dermatoses

      D. Wallach and M.-D. Vignon-Pennamen

      Version of Record online: 22 JUL 2015 | DOI: 10.1111/bjd.13955

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      What's already known about this topic?

      • Pyoderma gangrenosum and Sweet syndrome are the prototypic conditions of the vast group of the neutrophilic dermatoses, characterized by an aseptic infiltration of the skin by polymorphonuclear leucocytes.
      • A similar infiltration may also occur in internal organs, defining the neutrophilic disease.
      • The principles of the management of patients with a neutrophilic disease have been properly described.

      What does this study add?

      • The genetic and molecular mechanisms of neutrophilic inflammation are currently poorly understood.
      • They may be similar to the mechanisms of the monogenic autoinflammatory diseases, which are among the rare causes of neutrophilic dermatoses.

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