Clinical & Experimental Immunology

Cover image for Vol. 187 Issue 2

Edited By: Mark Peakman and Leonie Taams

Impact Factor: 3.148

ISI Journal Citation Reports © Ranking: 2015: 63/151 (Immunology)

Online ISSN: 1365-2249

Virtual Issues


Clinical & Experimental Immunology FREE Virtual Issues

Highlights in autoimmunity: pathogenesis, pathology and clinical features of disease

The articles here explore different aspects of the mechanisms that initiate autoimmunity, autoimmune pathophysiology and inflammatory pathways as well as aspects of autoimmune pathology, diagnosis and management of disease.

All articles in this collection have been published in issues of Immunology and Clinical & Experimental Immunology in 2015 and 2016 and are free to view online.

Highlights in autoimmunity: pathogenesis, pathology and clinical features of disease

From bench to clinic – highlights in translational immunology research

Translating basic research discoveries into clinically useful applications is key in tackling many diseases and immunological conditions. This collection of reviews and research papers from Clinical & Experimental Immunology outlines some of the important areas in translational immunology research in the diagnosis and treatment of a number of diseases. Covering areas such as neuroimmunology, autoimmunity, inflammation, immunotherapy for cancer and autoimmune disease, biomarkers and disease mechanisms, these are some of the most popular translational articles to be published in the journal in recent years.

From bench to clinic – highlights in translational immunology research

Type 1 diabetes: insights into pathophysiology, treatments and interventions

Identifying markers which can be used to determine those at risk of type 1 diabetes before the onset of disease, and developing interventions aimed at preventing dysregulated autoimmunity leading to type 1 diabetes are key areas of research aimed at tackling this disease. This collection of articles features some of the key reviews and papers published in Clinical & Experimental Immunology examining the mechanisms underlying the development of type 1 diabetes and different treatment strategies under investigation, in both humans and mouse models.

diabetes

Immune homeostasis and the hygiene hypothesis: modulating the microbiome in health and disease

This virtual issue aims to provide insights into the microbiome and its influence on health and disease. Mainly comprised of reviews, this collection of articles covers a broad range of different aspects of the microbiome and ‘hygiene hypothesis’, including the role helminth infections have on regulating immune homeostasis and the influence of microbiota on the development of diseases such as type-1 and type-2 diabetes, rheumatoid arthritis and lung disease. Other issues discussed include how factors such as diet, use of probiotics and faecal transplantation help to modulate the gut microbiome, and their potential in treating and preventing disease.

microbiome

Dying autologous cells as instructors of the immune system

Series Originators and Editors: Christian Berens and Martin Herrmann
December 2014

This virtual issue is based on a series of articles commissioned and collected together for Clinical & Experimental Immunology. The way in which the immune system reacts to dead and dying cells is key in the pathogenesis of a number of diseases, with impaired clearance of apoptotic cells being implicated in many conditions such as diabetes, Alzheimer’s disease, atherosclerosis and cancer. The articles in this series give some insight into how cell death and the immune system interact; we hope they will spark interest and debate and encourage research efforts into further elucidating the role of cell death in the immune system.
Figure 1

Complement - October 2012
A selection of key articles on complement, from Clinical & Experimental Immunology, were selected by Associate Editor, Marina Botto, in advance of the XXIV International Complement Workshop 2012.

All featured papers are free to access.

Complement - October 2010
A selection of key articles on complement, from Clinical & Experimental Immunology, were selected by Associate Editor, Marina Botto, in advance of the XXIII International Complement Workshop 2010.

All featured papers are free to access.

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