Cover image for Vol. 29 Issue 1

Editor-in-Chief: Professor Michael Sheaff

Impact Factor: 2.38

ISI Journal Citation Reports © Ranking: 2016: 29/79 (Pathology); 132/190 (Cell Biology)

Online ISSN: 1365-2303

Virtual Issue Collection

Welcome to the Cytopathology Virtual Issues page

Cytopathology Virtual Issue, January 2013
Highlights of 2012

The 2012 issue opened the year with a provocative article from the USA concerning cervical cancers that are difficult to prevent, based on personal experience of the author with clinical cytopathology and medicolegal practice. The same issue contained an epidemiological audit of cervical cancers in the NHS Cervical Screening Programme in the UK, which was unusual in reviewing biopsies as well as cytological slides preceding the development of invasive cancer.

 1 Type 1 and type 2 cervical carcinomas: some cervical cancers are more difficult to prevent with screening
R. M. Austin and C. Zhao
Cytopathology 2013; 23 (1) 6-12.

 2 Review of cytology and histopathology as part of the NHS Cervical Screening Programme audit of invasive cervical cancers
A. Castanon, S. Ferryman, J. Patnick and P. Sasieni
Cytopathology 2013; 23 (1) 13-22.

The April issue introduced the theme of ‘haematopathology’ in which Professor Zeppa explained why cytopathologists should ‘dare to tread’ in this area; and Lobo and colleagues demonstrated what cytopathology combined with immunocytochemistry and PCR contribute to diagnosis of KSHV-associated disorders in serous effusions.

 3 Haematocytopathology: why?
Cytopathology 2013; 23 (2) 73-75.

 4 Serous fluid cytology of multicentric Castleman’s disease and other lymphoproliferative disorders associated with Kaposi sarcoma-associated herpesvirus: a review with case reports
C. Lobo, S. Amin, A. Ramsay, T. Diss and G. Kocjan
Cytopathology 2013; 23 (2) 76-85.

The June issue emphasized the central role of the patient in gynaecological cytopathology with an article describing a pathologist-led clinic in Oxford where difficult diagnoses and conditions are discussed face-to-face with patients and their relatives. Other articles on related topics included a study considering which and why women default from follow up.

 5 The Pathology clinic – pathologists should see patients
S. Manek
Cytopathology 2013; 23 (3) 146-149.

 6 Which women default from follow-up cervical cytology tests? A cohort study within the TOMBOLA trial
L. Sharp, S. Cotton, A. Thornton, N. Gray, D. Wynes, L. Smart, N. Waugh, I. Duncan, M. Cruikshank and J. Little on behalf of the TOMBOLA group
Cytopathology 2013; 23 (3) 150-160.

The theme in August concerned the diagnosis of lung cancer and thymoma by endobronchial FNA and the efficacy of cytological specimens for EGFR mutation analysis.

 7 Fine needle aspiration cytology of non-small cell lung cancer: current state and future perspective
A. Fassina
Cytopathology 2013; 23 (4) 213-219.

 8 Diagnosis and subclassification of thymoma by minimally invasive fine needle aspiration directed by endobronchial ultrasound: a review and discussion of four cases
M.T. Moonim, R. Breen, B. Gill-Barman and G. Santis
Cytopathology 2013; 23 (4) 220-228.

 9 The impact of cytological specimens for EGFR mutation testing in non-small cell lung cancer: a single South East Asian laboratory’s analysis of 670 cases
B. Pang, M. Dettner, C.W. Ong, A.N. Dewar, S. Gupta, G.L. Lim, M.E. Nga, J.E. Seet, A. Qasim, T.M. Chin, R. Soo, R. Soong and M. Salto-Tellez
Cytopathology 2013; 23 (4) 229-236.

September supplements published abstracts of the British Association of Cytopathology in Keele, UK and the 37th European Congress of Cytopathology in Dubrovnik, Croatia.

The October issue focused on cytopathology training in Europe as part of the ‘common trunk’ of pathology training and the importance of integrating molecular biology in this training.

 10 Molecular diagnostics and the training of future tissue- and cell-based pathologists
M.A. Catherwood, F. Schmitt and M. Salto-Tellez
Cytopathology 2013; 23 (5) 283-285.

 11 Molecular diagnosis on tissue and cells: how it affects training and will affect practice
C. Boyd and D.P. Boyle
Cytopathology 2013; 23 (5) 286-294.

 12 The UEMS Section/Board of Pathology, Chapter 6: Requirements for Recognition of Postgraduate Training in Pathology: a presentation of the Paris document
M. Totsch, C. Cuvelier, L. Vass and A. Fassina
Cytopathology 2013; 23 (5) 295-299.

The December issue completed the year with review articles on the new NHS Cervical Screening Programme guidelines: Achievable standards, benchmarks for reporting and criteria for reporting cervical cytopathology.

 13 ABC3 Part I: a review of the guidelines for terminology, classification and management of cervical cytology in England
J.H.F. Smith
Cytopathology 2013; 23 (6) 353-370.

 14 ABC3 Part II: a review of the new criteria for evaluating cervical cytology in England
R.G. Blanks
Cytopathology 2013; 23 (6) 360-370.

Cytopathology Virtual Issue, January 2012

The issue concentrated on non-gynaecological cytology and extension of its role through immunocytochemistry, with a strong emphasis on clinical, histological and radiological correlation - and the need for standardisation of the wide variety of techniques used across Europe.


Should cytology be an acceptable means of diagnosing malignant mesothelioma?


The diagnostic and molecular characteristics of malignant mesothelioma and ovarian/peritoneal serous carcinoma


Towards credible immunocytochemical findings



Immunocytochemistry: an indispensible technique in routine cytology
Skoog and Tani


External quality control for immunocytochemistry on cytology samples: a review of UK NEQAS ICC (cytology module) results
Kirbis et al.


Immunocytochemistry in Europe: results of the European Federation of Cytology Societies (EFCS) enquiry
Schmitt et al.


Fine needle aspiration biopsy of hepatocellular carcinoma and hepatocellular nodular lesions: role, controversies and approach to diagnosis


Articles on gynaecological cytology discussed the current status of telepathology as well as clinical implications of diagnosis and treatment


Digital cytopathology: are we there yet? 


The use of digital images to evaluate the interobserver agreement on cervical smear readings in Italian cervical screening
Tinacci et al.


The long-term cytological and histological outcomes in women managed with loop excision treatment under local anaesthesia for high-grade cytological abnormalities

Woo et al.

The correspondence columns included a series of letters concerning the future of medical training in cytopathology and the importance of the EFCS in taking this forward. The final letter of the series refers to the earlier ones.


The UEMS training charter for pathology: a common trunk and a challenge ahead for the EFCS

Tötsch et al.

Cytopathology Virtual Issue, May 2011

The highlight of 2010 was publication of a ‘Eurocentric’ but international survey of medical training in cytopathology, with editorials providing the perspective from the USA, UK and Europe as a whole; all the following articles were published in June 2010.

 1 Survey of medical training in cytopathology carried out by the journal Cytopathology
Anshu, A. Herbert, B. Cochand-Priollet, P. Cross, M. Desai, R. Dina, J. Duskova, A. Evered, A. Farnsworth, W. Gray, S. S. Gupta, K. Kapila, I. Kardum-Skelin, V. Kloboves-Prevodnik, T. K. Kobayashi, H. Koutselini, W. Olszewski, B. Onal, M. B. Pitman, Ž. Marinšek, T. Sauer, U. Schenck, F. Schmitt, I. Shabalova, J. H. F. Smith, E. Tani, L. Vass, P. Vielh, H. Wiener
Cytopathology 2010; 21:, 147–156.
 2 Standardized Cytopathology Training through Accreditation in the United States
R. Tambouret, R. Nayar, M. B. Pitman, H. Ehya
Cytopathology 2010; 21:, 139-141.
 3 What should be done to improve cytopathology training in the UK?
B. Gill, S. Slater
Cytopathology 2010; 21:, 142-144.
 4 Plans for the future of cytopathology training in Europe
Beatrix Cochand-Priollet
Cytopathology 2010; 21:, 145-146.

Diagnostic non-gynaecological cytology comprises the majority of review articles and original articles, most with emphasis on multidisciplinary cooperation, histological correlation and ancillary tests as essential adjuncts to cytomorphology. The following were all published during the first half of 2010.

5 Endobronchial ultrasound-guided transbronchial needle aspiration cytology: a state of the art review
S. E. H. Cameron, R. S. Andrade, S. E. Pambuccian
Cytopathology 2010; 21:, 6-26.
6 Thyroid fine needle aspiration cytology: a review of the National Cancer Institute state of the science symposium
L. J. Layfield, E. S. Cibas, Z. Baloch
Cytopathology 2010; 21:, 75-85.
7 Evaluation of accuracy of fine needle aspiration cytology in BI-RADS3 category breast lesions: cytohistological correlation in 337 cases
C. Engohan-Aloghe, N. Hottat, J. Cosaert, R. Boutemy, I. Fayt, J.-C. Noël
Cytopathology 2010; 21:, 161-163.

Cervical cytology articles recently published include evidence for terminological classification based on outcome in the organized screening programme in the UK, clinical management enhanced by audit of discrepancies between cytology and colposcopy findings, and treatment of the lesions detected by screening.

 8 Comparison of cytology and histology results in English cervical screening laboratories before and after liquid-based cytology conversion: do the data provide evidence for a single category of high-grade dyskaryosis?
R. G. Blanks, R. S. Kelly
Cytopathology 2010; 21:, 368-373.
 9 Cervical cytology/histology discrepancy: a 4-year review of patient outcome
E. L. Moss, A. Moran, G. Douce, J. Parkes, R. W. Todd, C. W. E. Redman
Cytopathology 2010; 21:, 389-394.
 10 The treatment of CIN: what are the risks?
W. Prendiville
Cytopathology 2009; 20:, 145-153.

Cytopathology Virtual Issue, September 2010
Diversity of clinico-pathological topics in Cytopathology

This virtual issue has been selected to demonstrate the diversity of papers published bi-monthly in Cytopathology. Sigurdsson, from Iceland, describes the results of one of the most effective cervical screening programmes in the world, along with recent data on high-risk HPV prevalence as they move towards screening in the 'age of vaccination'. Farnsworth writes from experience in Australia, one of the first countries to introduce vaccination in a well-screened population. Wright et al. and Blanks, both from the UK, demonstrate how positive predictive value of cervical cytology is crucial to monitoring performance. Much needed Codes of Practice on non-gynaecological cytopathology were produced by the British Society for Clinical Cytology (Chandra et al., and Kocjan et al.). Zeppo et al. demonstrate the role of flow cytometry as an adjunct to fine needle aspiration (FNA) cytology in the diagnosis of lymphoma and Das et al. describe the diagnostic cytological features of large cell anaplastic lymphoma. In a letter to the editor, Fassina et al. challenge the widely perceived risks of FNA cytology in liver malignancy and describe their experience of the safety and clinical value the procedure.

1 Cervical screening in the era of HPV vaccination
A. Farnsworth
Cytopathology 2010; 21: 211-212.
2 Cervical cancer: cytological cervical screening in Iceland and implications of HPV vaccines
K. Sigurdsson
Cytopathology 2010; 21: 213-222.
3 Comparison of SurePath® and ThinPrep® liquid-based cervical cytology using positive predictive value, atypical predictive value and total predictive value as performance indicators
P. K. Wright, J. Marshall, M. Desai
Cytopathology 2010; 21: 374-378.
Using a graph of the abnormal predictive value versus the positive predictive value for the determination of outlier laboratories in the National Health Service cervical screening programme
R. G. Blanks
Cytopathology 2010; 21: 379-388.
Fine needle aspiration cytology and flow cytometry immunophenotyping of non-Hodgkin lymphoma: can we do better?
P. Zeppa, E. Vigliar, I. Cozzolino, G. Troncone, M. Picardi, A. De Renzo, F. Grimaldi, F. Pane, A. Vetrani, Lucio Palombini
Cytopathology 2010; 21: 300-310.
6 Anaplastic large cell lymphoma: a critical evaluation of cytomorphological features in seven cases
P. Das, V. K. Iyer, S. R. Mathur, R. Ray
Cytopathology 2010; 21: 251-258.
7 BSCC Code of Practice – fine needle aspiration cytology
G. Kocjan, A. Chandra, P. Cross, K. Denton, T. Giles, A. Herbert, P. Smith, D. Remedios, P. Wilson
Cytopathology 2009; 20: 283-296.
8 The BSCC Code of Practice – exfoliative cytopathology (excluding gynaecological cytopathology)
A. Chandra, P. Cross, K. Denton, T. Giles, D. Hemming, C. Payne, A. Wilson, P. Wilson
Cytopathology 2009; 20: 211-223.
9 Seeding of tumour cells after fine needle aspiration cytology in liver nodules: myth or reality?
A. Fassina, M. Fabbro, R. Cappellesso, M. Fassan
Cytopathology 2010; 21: 413-414.

Cytopathology Virtual Issue, April 2010
Cervical Screenings - Practice and Guidelines

 1European guidelines for quality assurance in cervical cancer screening: recommendations for cytology laboratories
H. G. Wiener, P. Klinkhamer, U. Schenck, M. Arbyn, J. Bulten, C. Bergeron, A. Herbert

 2European guidelines for quality assurance in cervical cancer screening: recommendations for collecting samples for conventional and liquid–based cytology
M. Arbyn, A. Herbert, U. Schenck, P. Nieminen, J. Jordan, E. Mcgoogan, J. Patnick, C. Bergeron, J-J. Baldauf, P. Klinkhamer, J. Bulten, P. Martin-Hirsch

 3European guidelines for quality assurance in cervical cancer screening: recommendations for cervical cytology terminology
A. Herbert, C. Bergeron, H. Wiener, U. Schenck, P. Klinkhamer, J. Bulten, M. Arbyn

 4The revised BSCC terminology for abnormal cervical cytology
K. J. Denton, A. Herbert, L. S. Turnbull, C. Waddell, M. S. Desai, D. N. Rana, N. Dudding, J. H. F. Smith

 5European guidelines for quality assurance in cervical cancer screening: recommendations for clinical management of abnormal cervical cytology, part 1
J. Jordan, M. Arbyn, P. Martin-Hirsch, U. Schenck, J-J. Baldauf, D. Da Silva, A. Anttila, P. Nieminen, W. Prendiville

 6European guidelines for clinical management of abnormal cervical cytology, Part 2
J. Jordan, P. Martin-Hirsch, M. Arbyn, U. Schenck, J.-J. Baldauf, D. Da Silva, A. Anttila, P. Nieminen, W. Prendiville

 7The treatment of CIN: what are the risks?
W. Prendiville

Cytopathology Virtual Issue, April 2010
Non-Gynaecological Cytology - Practice and Guidelines

 1BSCC code of practice for non-gynaecological cytology: what are the next steps?
Beatrix Cochand-Priollet

 2The BSCC Code of Practice 0150 exfoliative cytopathology (excluding gynaecological cytopathology)
A. Chandra, P. Cross, K. Denton, T. Giles, D. Hemming, C. Payne, A. Wilson, P. Wilson

 3Head and neck cancer in the UK: what is expected of cytopathology?
G. Kocjan, A. Ramsay, T. Beale, P. O'Flynn

 4Thyroid FNAC cytology: can we do it better?
D. N. Poller, E. B. Stelow, C. Yiangou

 5The role of liquid-based cytology in the investigation of thyroid lesions
M. Stamataki, D. Anninos, E. Brountzos, J. Georgoulakis, J. Panayiotides, Z. Christoni, G. Peros, P. Karakitsos