Genes to Cells
© The Molecular Biology Society of Japan/John Wiley & Sons Australia, Ltd
Edited By: Mitsuhiro Yanagida
Impact Factor: 2.805
ISI Journal Citation Reports © Ranking: 2014: 70/167 (Genetics & Heredity); 111/184 (Cell Biology)
Online ISSN: 1365-2443
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Recently Published Articles
- Postnatal knockdown of dok-7 gene expression in mice causes structural defects in neuromuscular synapses and myasthenic pathology
Takahiro Eguchi, Tohru Tezuka, Sadanori Miyoshi and Yuji Yamanashi
Article first published online: 18 APR 2016 | DOI: 10.1111/gtc.12370
Dok-7 is required for the embryonic formation of neuromuscular junction (NMJ), an essential synapse for muscle contraction, and its genetic mutations underlie an NMJ disorder, DOK7 myasthenia. We demonstrate that postnatal knockdown of dok-7 gene expression in mice causes structural defects in NMJs and myasthenic symptoms including reduction in body weight and motor function. Thus, correct physiological levels of dok-7 expression are required for the postnatal maintenance of NMJs, implying its relevance in myasthenia.
- Midori-ishi Cyan/monomeric Kusabira-Orange-based fluorescence resonance energy transfer assay for characterization of various E3 ligases
Ryota Otsubo, Minsoo Kim, Jihye Lee and Chihiro Sasakawa
Article first published online: 18 APR 2016 | DOI: 10.1111/gtc.12369
Our results demonstrate that the MiCy/mKO-based FRET assay is useful for characterizing E3 ligases, as well as for high-throughput E3 inhibitor screening.
- Anillin-related protein Mid1 regulates timely formation of the contractile ring in the fission yeast Schizosaccharomyces japonicus
Tsuyoshi Yasuda, Masak Takaine, Osamu Numata and Kentaro Nakano
Article first published online: 5 APR 2016 | DOI: 10.1111/gtc.12368
We investigated the role of S. japonicus Mid1 during mitosis to compare the molecular mechanisms that determine the cell division site in Schizosaccharomyces. Although the Mid1 dependency for positional control of the cell division site is possibly different between the fission yeast species, we found that Sj Mid1 enhanced CR formation, in a manner possibly similar to that by S. pombe Mid1.
- Mammalian target of rapamycin (mTOR) complex 2 regulates filamin A-dependent focal adhesion dynamics and cell migration
Tatsuhiro Sato, Junko Ishii, Yuki Ota, Eri Sasaki, Yoshio Shibagaki and Seisuke Hattori
Article first published online: 5 APR 2016 | DOI: 10.1111/gtc.12366
We found that filamin A, a for key regulator actin cytoskeletal integrity and cell migration, was phosphorylated at serine 2152 by mTORC2. mTORC2 regulates focal adhesion formation through the phosphorylation of S2152 of filamin A.
- Distribution of human single-nucleotide polymorphisms is approximated by the power law and represents a fractal structure
Norio Gouda, Yuh Shiwa, Motohiro Akashi, Hirofumi Yoshikawa, Ken Kasahara and Mitsuru Furusawa
Article first published online: 31 MAR 2016 | DOI: 10.1111/gtc.12344