Genes to Cells
© 2015 The Molecular Biology Society of Japan/Wiley Publishing Asia Pty Ltd.
Edited By: Mitsuhiro Yanagida
Impact Factor: 2.855
ISI Journal Citation Reports © Ranking: 2013: 70/165 (Genetics & Heredity); 108/185 (Cell Biology)
Online ISSN: 1365-2443
See and read about our journal covers, each available as free pdf downloads.
Online Only news
Genes to Cells will be available online only from 2015. For more information and to receive electronic Table of Content alerts each time a new issue is published online, please see here.
Recently Published Articles
- Trp250-hK2 is defective in intracellular trafficking and activates the unfolded protein response
Eun Ju Choi, Sei Mee Yoon, Suman Lee and Jinu Lee
Article first published online: 6 APR 2015 | DOI: 10.1111/gtc.12242
The T allele on rs198977, a SNP in KLK2 codes for W-hK2 and are associated with lower level of hK2 and higher risk of prostate cancer. W-hK2 is defective in cellular trafficking and activates unfolded protein response, suggesting a mechanism underlying this functional SNP.
- RNA pol II transcript abundance controls condensin accumulation at mitotically up-regulated and heat-shock-inducible genes in fission yeast
Norihiko Nakazawa, Kenichi Sajiki, Xingya Xu, Alejandro Villar-Briones, Orie Arakawa and Mitsuhiro Yanagida
Article first published online: 6 APR 2015 | DOI: 10.1111/gtc.12239
Conserved protein complex ‘condensin’ is a central player for chromosome dynamics. We demonstrated that RNA polymerase II (pol II)-mediated transcripts cause condensin accumulation at fission yeast (Schizosaccharomyces pombe) chromosomes. Abundant pol II transcription may require active condensin prior to proper chromosome segregation.
- Dendritic cell SIRPα regulates homeostasis of dendritic cells in lymphoid organs
Ken Washio, Takenori Kotani, Yasuyuki Saito, Datu Respatika, Yoji Murata, Yoriaki Kaneko, Hideki Okazawa, Hiroshi Ohnishi, Atsushi Fukunaga, Chikako Nishigori and Takashi Matozaki
Article first published online: 27 MAR 2015 | DOI: 10.1111/gtc.12238
- White spotting phenotype induced by targeted REST disruption during neural crest specification to a melanocyte cell lineage
Hitomi Aoki, Akira Hara and Takahiro Kunisada
Article first published online: 27 MAR 2015 | DOI: 10.1111/gtc.12235
The transcriptional repressor RE1-silencing transcription factor (REST), also known as neuron-restrictive silencer factor (NRSF), acts as a negative regulator of neuron-specific genes. While Rest null mice die by E11.5 days with hypoplastic morphological changes, neural crest cell-specific Rest conditional knockout (CKO) mice showed the neonatal death due to swelling of the digestive tract, and the downregulation of acetylcholinesterase activity in the NCC-derived myenteric plexus in the stomach. Here, we generated a viable heterozygote of Rest CKO mice and identified their white spotting phenotype and corresponding localized reduction in skin melanoblasts, suggesting the involvement of Rest in the early melanocyte specification stage.
- Notch signaling regulates venous arterialization during zebrafish fin regeneration
Yoshiko Kametani, Neil C. Chi, Didier Y.R. Stainier and Shinji Takada
Article first published online: 25 MAR 2015 | DOI: 10.1111/gtc.12234
During regeneration of the zebrafish caudal fin, vein-derived cells contributed to the reconstructed arteries. Furthermore, the initiation of this arterialization was dependent on Notch signaling.