Genes to Cells

Cover image for Vol. 21 Issue 8

Edited By: Mitsuhiro Yanagida

Impact Factor: 2.481

ISI Journal Citation Reports © Ranking: 2015: 85/165 (Genetics & Heredity); 123/187 (Cell Biology)

Online ISSN: 1365-2443

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Recently Published Articles

  1. Biophysical characterization of drug-resistant mutants of fibroblast growth factor receptor 1

    Kaito Yoza, Rika Himeno, Shinjiro Amano, Yoshihiro Kobashigawa, Shun Amemiya, Natsuki Fukuda, Hiroyuki Kumeta, Hiroshi Morioka and Fuyuhiko Inagaki

    Version of Record online: 25 AUG 2016 | DOI: 10.1111/gtc.12405

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    Affinity of drug-resistant mutants of FGFR1 for ATP-competitive inhibitors were evaluated by biophysical techniques. The only marked reduction in affinity was observed that of PD173074 for the gatekeeper mutant (V561M). The molecular brake mutant (N546K) exhibited increased affinity for the ATP-analogue. These findings will help to clarify the mechanism of drug-resistance in mutant tyrosine kinases.

  2. PKCη deficiency improves lipid metabolism and atherosclerosis in apolipoprotein E-deficient mice

    Kumiko Torisu, Xueli Zhang, Mari Nonaka, Takahide Kaji, Daisuke Tsuchimoto, Kosuke Kajitani, Kunihiko Sakumi, Takehiro Torisu, Kazuhiro Chida, Katsuo Sueishi, Michiaki Kubo, Jun Hata, Takanari Kitazono, Yutaka Kiyohara and Yusaku Nakabeppu

    Version of Record online: 22 AUG 2016 | DOI: 10.1111/gtc.12402

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    We found that the dyslipidemia observed in Prkch+/+Apoe−/− mice was improved in Prkch−/−Apoe−/− mice. HFD-induced liver steatosis was markedly attenuated in Prkch−/−Apoe−/− mice. Consistent with improvements of dyslipidemia, atherosclerotic lesions were decreased in HFD-fed Prkch−/−Apoe−/− mice.

  3. Application of NanoLuc to monitor the intrinsic promoter activity of GRP78 using the CRISPR/Cas9 system

    Kentaro Oh-hashi, Eri Furuta, Junpei Norisada, Fumimasa Amaya, Yoko Hirata and Kazutoshi Kiuchi

    Version of Record online: 12 AUG 2016 | DOI: 10.1111/gtc.12401

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    We applied a highly sensitive small luciferase, NanoLuc, to establish a knock-in cell line using the CRISPR/Cas9 system and characterized the endogenous promoter activity of the human GRP78 gene.

  4. Control of the heat stress-induced alternative splicing of a subset of genes by hnRNP K

    Koichi Yamamoto, Mari T. Furukawa, Kazuhiro Fukumura, Arisa Kawamura, Tomoko Yamada, Hitoshi Suzuki, Tetsuro Hirose, Hiroshi Sakamoto and Kunio Inoue

    Version of Record online: 5 AUG 2016 | DOI: 10.1111/gtc.12400

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    We found that RNA-binding proteins hnRNP K and PSF/SFPQ are necessary for the alternative splicing of HSP105 during heat stress. Our results showed that a group of genes is alternatively spliced during heat stress in an hnRNP K-dependent manner, whereas hnRNP K is not necessary for the stress-induced alternative splicing of the remaining genes. Among the latter group, we found that SRp38/SRSF10 and SC35/SRSF2 are necessary for the alternative splicing of TNRC6A upon heat stress.

  5. CRMP1 and CRMP2 have synergistic but distinct roles in dendritic development

    Hiroko Makihara, Shiori Nakai, Wataru Ohkubo, Naoya Yamashita, Fumio Nakamura, Hiroshi Kiyonari, Go Shioi, Aoi Jitsuki-Takahashi, Haruko Nakamura, Fumiaki Tanaka, Tomoko Akase, Pappachan Kolattukudy and Yoshio Goshima

    Version of Record online: 2 AUG 2016 | DOI: 10.1111/gtc.12399

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    In vitro finding suggests that both CRMP1 and CRMP2 are downstream molecules of Sema3A signaling. Dendritic spine density and branching were reduced in double-heterozygous sema3A+/−;crmp2+/− and sema3A+/−;crmp1+/− mice, but the phenotypic defects had no genetic interaction between crmp1 and crmp2. These findings suggest that both CRMP1 and CRMP2 mediate Sema3A signaling to regulate dendritic spine maturation and patterning, but through overlapping and distinct signaling pathways.

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