Genes to Cells

Cover image for Vol. 21 Issue 7

Edited By: Mitsuhiro Yanagida

Impact Factor: 2.481

ISI Journal Citation Reports © Ranking: 2015: 85/165 (Genetics & Heredity); 123/187 (Cell Biology)

Online ISSN: 1365-2443

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Recently Published Articles

  1. You have full text access to this OnlineOpen article
    Caenorhabditis elegans homologue of Prox1/Prospero is expressed in the glia and is required for sensory behavior and cold tolerance

    Eriko Kage-Nakadai, Akane Ohta, Tomoyo Ujisawa, Simo Sun, Yoshikazu Nishikawa, Atsushi Kuhara and Shohei Mitani

    Version of Record online: 12 JUL 2016 | DOI: 10.1111/gtc.12394

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    We performed RNA interference (RNAi) screening for transcription factors that regulate the expression of an amphid sheath glial cell marker and identified pros-1, which encodes a homeodomain transcription factor homologous to Drosophila prospero/mammalian Prox1, as a positive regulator. The functional PROS-1::EGFP fusion protein was localized in the nuclei of the glia and the excretory cell but not in the amphid sensory neurons. We further found that the structure and functions of sensory neurons, such as the morphology of sensory endings, sensory behavior and sensory-mediated cold tolerance, appeared to be affected by pros-1 RNAi.

  2. NEK6-mediated phosphorylation of human TPP1 regulates telomere length through telomerase recruitment

    Yugo Hirai, Miki Tamura, Junji Otani and Fuyuki Ishikawa

    Version of Record online: 11 JUL 2016 | DOI: 10.1111/gtc.12391

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    Human telomere protein TPP1 is phosphorylated in G2/M-phase cells by NEK6 kinase to regulate telomerase reactions.

  3. Balance between cAMP and Ca2+ signals regulates expression levels of pituitary adenylate cyclase-activating polypeptide gene in neurons

    Mamoru Fukuchi, Yuki Kuwana, Akiko Tabuchi and Masaaki Tsuda

    Version of Record online: 7 JUL 2016 | DOI: 10.1111/gtc.12393

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    Ca2+ signaling evoked by excitatory neurotransmission not only activates the Pacap promoter but also prevents Pacap mRNA degradation. In contrast, cAMP signals, which can be induced by Gs-coupled GPCR activation, reduce the expression levels of Pacap mRNA. However, cAMP signals also participate in the synergistic induction of Pacap in the presence of Ca2+ signals via calcineurin/CRTC1/CREB, resulting in robust PACAP expression in neurons.

  4. Fluorescent-based evaluation of chaperone-mediated autophagy and microautophagy activities in cultured cells

    Masahiro Sato, Takahiro Seki, Ayumu Konno, Hirokazu Hirai, Yuki Kurauchi, Akinori Hisatsune and Hiroshi Katsuki

    Version of Record online: 5 JUL 2016 | DOI: 10.1111/gtc.12390

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    We established a novel method to monitor the activities of chaperone-mediated autophagy and microautophagy, separately, in cultured cell lines and primary cultured neurons.

  5. Targeting ID2 expression triggers a more differentiated phenotype and reduces aggressiveness in human salivary gland cancer cells

    Tomoki Sumida, Akiko Ishikawa, Hiroyuki Nakano, Tomohiro Yamada, Yoshihide Mori and Pierre-Yves Desprez

    Version of Record online: 1 JUL 2016 | DOI: 10.1111/gtc.12389

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    Inhibitors of DNA binding (ID) proteins are negative regulators of basic helix-loop-helix transcription factors, and generally stimulate cell proliferation and inhibit differentiation. ID2 knockdown triggers important changes in cell behavior, that is, it significantly reduces the expression of N-cadherin, vimentin and Snail, induces E-cadherin expression, and leads to a more differentiated phenotype exemplified by changes in cell shape. ID2 therefore represents a potential therapeutic target during salivary gland cancer progression. HSG, human salivary gland.