Genes to Cells

Cover image for Vol. 20 Issue 10

Edited By: Mitsuhiro Yanagida

Impact Factor: 2.805

ISI Journal Citation Reports © Ranking: 2014: 70/167 (Genetics & Heredity); 111/184 (Cell Biology)

Online ISSN: 1365-2443

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Genes to Cells will be available online only from 2015. For more information and to receive electronic Table of Content alerts each time a new issue is published online, please see here.

Recently Published Articles

  1. Differential binding of ppGpp and pppGpp to E. coliRNA polymerase: photo-labeling and mass spectral studies

    Kirtimaan Syal and Dipankar Chatterji

    Article first published online: 8 OCT 2015 | DOI: 10.1111/gtc.12304

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    ppGpp and pppGpp have an overlapping binding site on RNA polymerase (RNAP). 8-azido ppGpp is mapped on β’ and β subunit of RNAP. 8-azido pppGpp is mapped on β’ subunit of RNAP.

  2. Interaction of human mitochondrial transcription factor A in mitochondria: its involvement in the dynamics of mitochondrial DNA nucleoids

    Katsumi Kasashima and Hitoshi Endo

    Article first published online: 7 OCT 2015 | DOI: 10.1111/gtc.12306

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    We visualized the interaction of TFAM molecules in mitochondria by the Kusabira-Green reporter. The TFAM interaction is involved in the dynamics of mitochondrial nucleoids.

  3. 7-Ketocholesterol-induced lysosomal dysfunction exacerbates vascular smooth muscle cell calcification via oxidative stress

    Ryo Sudo, Fumiaki Sato, Takuya Azechi and Hiroshi Wachi

    Article first published online: 30 SEP 2015 | DOI: 10.1111/gtc.12301

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    In our in vitro study, we demonstrated that the lysosomal-dysfunction-dependent oxidative stress played a pivotal role in the progression of vascular smooth muscle cells calcification by a low concentration of 7-ketocholesterol, and that even normal serum levels of 7-ketocholesterol can be a risk factor for vascular calcification.

  4. Genomic confirmation of nutrient-dependent mutability of mutators in Escherichia coli

    Saburo Tsuru, Yuuka Ishizawa, Atsushi Shibai, Yusuke Takahashi, Daisuke Motooka, Shota Nakamura and Tetsuya Yomo

    Article first published online: 28 SEP 2015 | DOI: 10.1111/gtc.12300

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    We used two mutator strains of Escherichia coli to explore the nutrient dependence of mutation rates at the genomic level. These strains were transferred repeatedly under different nutritional conditions for hundreds of generations to accumulate mutations. Whole-genome sequencing of the offspring revealed that the nutrient dependence of the mutation rates was pervasive at the genomic scale.

  5. Escherichia coli inner membrane protein YciB interacts with ZipA that is important for cell division

    Noor Afiza Badaluddin and Madoka Kitakawa

    Article first published online: 22 SEP 2015 | DOI: 10.1111/gtc.12299

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    Deletion mutant of yciB (ΔyciB) is shorter in the cell length compared to wild type and on the other hand an overexpression of yciB causes elongation of the cell. We also found that the septum localization of ZipA, an essential protein of cell division, was disturbed in ΔyciB mutant. Furthermore, purified YciB protein directly interacted with ZipA.