Genes to Cells

Cover image for Vol. 22 Issue 1

Edited By: Mitsuhiro Yanagida

Impact Factor: 2.481

ISI Journal Citation Reports © Ranking: 2015: 85/166 (Genetics & Heredity); 123/187 (Cell Biology)

Online ISSN: 1365-2443

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Recently Published Articles

  1. Secretome analysis to elucidate metalloprotease-dependent ectodomain shedding of glycoproteins during neuronal differentiation

    Kazuya Tsumagari, Kyoko Shirakabe, Mayu Ogura, Fuminori Sato, Yasushi Ishihama and Atsuko Sehara-Fujisawa

    Version of Record online: 13 JAN 2017 | DOI: 10.1111/gtc.12466

    Thumbnail image of graphical abstract

    We succeeded in the establishment of a sensitive and reliable method to systematically screen glycoproteins that are secreted from differentiating neurons through metalloprotease-dependent ectodomain shedding. Our results show the landscape of ectodomain shedding in differentiating neurons, which should help elucidate the mechanisms of neurogenesis and the pathogeneses of neurological disorders.

  2. Novel tRNA function in amino acid sensing of yeast Tor complex1

    Yoshiaki Kamada

    Version of Record online: 13 JAN 2017 | DOI: 10.1111/gtc.12462

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    Tor complex1 (TORC1) plays a pivotal role in amino acid sensing. In this study, I found that tRNA regulates TORC1. Based on the results, model of tRNA-mediated TORC1 regulation is proposed.

  3. You have full text access to this OnlineOpen article
    Functional mutations in spike glycoprotein of Zaire ebolavirus associated with an increase in infection efficiency

    Mahoko Takahashi Ueda, Yohei Kurosaki, Taisuke Izumi, Yusuke Nakano, Olamide K. Oloniniyi, Jiro Yasuda, Yoshio Koyanagi, Kei Sato and So Nakagawa

    Version of Record online: 13 JAN 2017 | DOI: 10.1111/gtc.12463

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    Analyzing all available Zaire ebolavirus glycoprotein sequences, we found that A82V mutant was fixed in the 2014–2015 outbreak, whereas T544I was not, both of which are under positive selection. Pseudotype assays demonstrated that the A82V mutation caused a small increase in viral infectivity compared with the T544I mutation. Our findings suggest that a driving force for Ebola virus evolution via glycoprotein may be a balance between costs and benefits of its virulence.

  4. You have full text access to this OnlineOpen article
    Hippo vs. Crab: tissue-specific functions of the mammalian Hippo pathway (pages 6–31)

    Miki Nishio, Tomohiko Maehama, Hiroki Goto, Keisuke Nakatani, Wakako Kato, Hirofumi Omori, Yosuke Miyachi, Hideru Togashi, Yohei Shimono and Akira Suzuki

    Version of Record online: 12 JAN 2017 | DOI: 10.1111/gtc.12461

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    The Hippo pathway, which is triggered by external forces such as cell crowding, or changes to the extracellular matrix or cell polarity, and particular growth factors, is a vital suppressor of tumorigenesis and often inactivated in human cancers. In this review, we attempt to systematically summarize the phenotypes of conditionally gene-targeted mice bearing tissue-specific mutations of Hippo signaling components. These findings should advance the generation of new, more effective, targeted anti-cancer therapies.

  5. Detection of DNA double-strand breaks by pulsed-field gel electrophoresis (pages 84–93)

    Yuri Kawashima, Nahomi Yamaguchi, Rie Teshima, Hisashi Narahara, Yoshio Yamaoka, Hirofumi Anai, Yoshihiro Nishida and Katsuhiro Hanada

    Version of Record online: 15 DEC 2016 | DOI: 10.1111/gtc.12457

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    Many physiological DSBs occur at DNA replication sites, but the molecular mechanisms underlying this remain poorly understood. There was therefore a need to develop a highly specific method to detect DSBs at DNA replication sites. We developed the system that would be applicable to studies analyzing the mechanistic details of DNA repair, the DNA damage response and the activity of DNA-damaging agents.

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