Genes to Cells

Cover image for Vol. 20 Issue 8

Edited By: Mitsuhiro Yanagida

Impact Factor: 2.805

ISI Journal Citation Reports © Ranking: 2014: 70/167 (Genetics & Heredity); 111/184 (Cell Biology)

Online ISSN: 1365-2443

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Recently Published Articles

  1. Structural analysis of the mechanism of phosphorylation of a critical autoregulatory tyrosine residue in FGFR1 kinase domain

    Yoshihiro Kobashigawa, Shinjiro Amano, Mariko Yokogawa, Hiroyuki Kumeta, Hiroshi Morioka, Masayori Inouye, Joseph Schlessinger and Fuyuhiko Inagaki

    Article first published online: 24 AUG 2015 | DOI: 10.1111/gtc.12277

    Thumbnail image of graphical abstract

    Trans-phosphorylation of Tyr residue in the activation-loop of receptor tyrosine kinases is a key step in triggering cellular signal transduction pathway. Here, the molecular mechanism underlying the control of trans-phosphorylation of a critical auto-regulatory site in FGF receptors catalytic domain was elucidated by NMR analysis.

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    MT1-MMP recognition by ERM proteins and its implication in CD44 shedding

    Shin-ichi Terawaki, Ken Kitano, Miki Aoyama, Tomoyuki Mori and Toshio Hakoshima

    Article first published online: 20 AUG 2015 | DOI: 10.1111/gtc.12276

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    Structural and physical data showed that radixin simultaneously binds both MT1-MMP and CD44, indicating ERM protein-mediated colocalization of MT1-MMP and its substrate CD44 and anchoring to F-actin. Our study implies that ERM proteins contribute towards accelerated CD44 shedding by MT1-MMP through ERM protein-mediated interactions between their cytoplasmic tails.

  3. Role of 100S ribosomes in bacterial decay period

    Ksenia Shcherbakova, Hideki Nakayama and Nobuo Shimamoto

    Article first published online: 20 AUG 2015 | DOI: 10.1111/gtc.12273

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    Microscopic images of ribosomes with chromosomal rpsJ fused with B-maggio gfp at 6 h (top) and at 60 h (bottom).

  4. Deletion of Prdm8 impairs development of upper-layer neocortical neurons

    Mayuko Inoue, Ryota Iwai, Emiko Yamanishi, Kazuyuki Yamagata, Mariko Komabayashi-Suzuki, Aya Honda, Tae Komai, Hitoshi Miyachi, Satsuki Kitano, Chisato Watanabe, Waka Teshima and Ken-ichi Mizutani

    Article first published online: 18 AUG 2015 | DOI: 10.1111/gtc.12274

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    Upper-layer neocortical neurons are the most prominent distinguishing features of the mammalian neocortex compared with those of the avian dorsal cortex and are vastly expanded in primates. Here we found that Prdm8, a member of the PR domain protein family, was specifically expressed in the postnatal upper-layer neocortex. We generated homozygous Prdm8 knockout mice, and found that deletion of Prdm8 causes a reduced brain weight. Immunohistochemistry revealed that number of late-born upper-layer neurons were significantly decreased in Prdm8 knockout mice.