Genes to Cells

Cover image for Vol. 20 Issue 7

Edited By: Mitsuhiro Yanagida

Impact Factor: 2.805

ISI Journal Citation Reports © Ranking: 2014: 70/167 (Genetics & Heredity); 111/184 (Cell Biology)

Online ISSN: 1365-2443

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Genes to Cells will be available online only from 2015. For more information and to receive electronic Table of Content alerts each time a new issue is published online, please see here.

Recently Published Articles

  1. Identification of novel target genes specifically activated by deregulated E2F in human normal fibroblasts

    Hodaka Kitamura, Eiko Ozono, Ritsuko Iwanaga, Andrew P. Bradford, Junko Okuno, Emi Shimizu, Kenta Kurayoshi, Kazuyuki Kugawa, Hiroyuki Toh and Kiyoshi Ohtani

    Article first published online: 23 JUL 2015 | DOI: 10.1111/gtc.12268

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    The transcription factor E2F plays crucial roles in tumor suppression when deregulated from the tumor suppressor pRB. Deregulated E2F activates some tumor suppressor genes such as ARF and TAp73, which are not activated by physiological E2F induced by growth stimulation. We have now identified nine novel targets of deregulated E2F that are involved in the p53 and RB pathways.

  2. Efficient production of T cells from mouse pluripotent stem cells by controlled expression of Lhx2

    Kenji Kitajima, Manami Kawaguchi, Kazuya Miyashita, Marino Nakajima, Mai Kanokoda and Takahiko Hara

    Article first published online: 7 JUL 2015 | DOI: 10.1111/gtc.12266

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    LIM-homeobox transcription factor Lhx2 induces engraftable HSC-like cells from mouse ESCs/iPSCs. However, these cells could not produce T cells. Here, we reveal that Lhx2-induced HSC-like cells can be differentiated into T cells by removal of Lhx2 expression.

  3. hCAS/CSE1L regulates RAD51 distribution and focus formation for homologous recombinational repair

    Satoshi Okimoto, Jiying Sun, Atsuhiko Fukuto, Yasunori Horikoshi, Shun Matsuda, Tomonari Matsuda, Masae Ikura, Tsuyoshi Ikura, Shinichi Machida, Hitoshi Kurumizaka, Yoichi Miyamoto, Masahiro Oka, Yoshihiro Yoneda, Yoshiaki Kiuchi and Satoshi Tashiro

    Article first published online: 30 JUN 2015 | DOI: 10.1111/gtc.12262

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    We found that hCAS/CSE1L regulates the nuclear concentration of RAD51 and nuclear RAD51 focus formation. hCAS/CSE1L was required to repress the HR activity and to keep chromosome stability. These findings suggest that hCAS/CSE1L is responsible for genome integrity by regulating the intracellular distribution of RAD51.

  4. Azoles activate Atf1-mediated transcription through MAP kinase pathway for antifungal effects in fission yeast

    Lingling Hu, Yue Fang, Tsutomu Hayafuji, Yan Ma and Tomoyuki Furuyashiki

    Article first published online: 23 JUN 2015 | DOI: 10.1111/gtc.12263

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    Azoles activate stress-activated MAP kinase pathway, thereby facilitating Atf1-mediated transcription for antifungal effects.

  5. Loss of ADAR1 in human iPS cells promotes caspase3-mediated apoptotic cell death

    Shota Katayama, Kaori Shimoda and Yuji Takenaga

    Article first published online: 18 JUN 2015 | DOI: 10.1111/gtc.12261

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    Loss of ADAR1 induces caspase3-mediated apoptotic cell death. However, it is dispensable for maintenance of pluripotency.