Genes to Cells

Cover image for Vol. 22 Issue 6

Edited By: Mitsuhiro Yanagida

Impact Factor: 1.993

ISI Journal Citation Reports © Ranking: 2016: 106/166 (Genetics & Heredity); 145/189 (Cell Biology)

Online ISSN: 1365-2443

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Recently Published Articles

  1. Two zinc finger proteins from Mycobacterium smegmatis: DNA binding and activation of transcription

    Subho Ghosh and Dipankar Chatterji

    Version of Record online: 22 JUN 2017 | DOI: 10.1111/gtc.12507

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    Two C-terminal Zn-finger proteins from Mycobacterium smegmatis are described in this article. They are characterized structurally, and the biochemical functions have been elucidated. Experiments indicated that both bind RNA polymerase and act as transcription activators.

  2. Medaka and zebrafish contactin1 mutants as a model for understanding neural circuits for motor coordination

    Miki Takeuchi, Chikako Inoue, Akiko Goshima, Yusuke Nagao, Koichi Shimizu, Hiroki Miyamoto, Takashi Shimizu, Hisashi Hashimoto, Shigenobu Yonemura, Atsuo Kawahara, Yutaka Hirata, Masayuki Yoshida and Masahiko Hibi

    Version of Record online: 22 JUN 2017 | DOI: 10.1111/gtc.12509

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    Cntn1b is required for controlling head position in rheotaxis. (A) Experimental setup for analyzing swimming behavior. (B) Medaka cntn1b (ro) mutants cannot keep a stereotaxic position while swimming into the water flow.

  3. Roles of afadin in functional differentiations of hippocampal mossy fiber synapse

    Xiaoqi Geng, Tomohiko Maruo, Kenji Mandai, Irwan Supriyanto, Muneaki Miyata, Shotaro Sakakibara, Akira Mizoguchi, Yoshimi Takai and Masahiro Mori

    Version of Record online: 20 JUN 2017 | DOI: 10.1111/gtc.12508

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    Roles of afadin in functional differentiations of the hippocampal mossy fiber synapse remain elusive. Geng et al. show that afadin plays roles in the functional differentiations of the presynapse and the postsynapse of this synapse.

  4. Endoplasmic reticulum proteins SDF2 and SDF2L1 act as components of the BiP chaperone cycle to prevent protein aggregation

    Tsutomu Fujimori, Ryoji Suno, Shun-ichiro Iemura, Tohru Natsume, Ikuo Wada and Nobuko Hosokawa

    Version of Record online: 9 JUN 2017 | DOI: 10.1111/gtc.12506

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    SDF2 and SDF2L1 are ER-resident proteins, and SDF2 is constitutively expressed, whereas SDF2L1 expression is induced by ER stress. These homologue proteins associated with non-native proteins and prevented the aggregation of misfolded cargo proteins. Both SDF2 and SDF2L1 form a stable complex with ERdj3 and act as components in the BiP chaperone cycle.

  5. Pervasive yet nonuniform contributions of Dcp2 and Cnot7 to maternal mRNA clearance in zebrafish

    Yuichiro Mishima and Yukihide Tomari

    Version of Record online: 30 MAY 2017 | DOI: 10.1111/gtc.12504

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    mRNA degradation is a fundamental biological process that erases transcribed genetic information from cells. In this study, the authors analyzed contributions of a decapping enzyme Dcp2 and a deadenylase Cnot7 to maternal mRNA clearance in zebrafish.