Genes to Cells

Cover image for Vol. 21 Issue 12

Edited By: Mitsuhiro Yanagida

Impact Factor: 2.481

ISI Journal Citation Reports © Ranking: 2015: 85/166 (Genetics & Heredity); 123/187 (Cell Biology)

Online ISSN: 1365-2443

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Recently Published Articles

  1. Epigenetic regulation of the glucose transporter gene Slc2a1 by β-hydroxybutyrate underlies preferential glucose supply to the brain of fasted mice

    Kosuke Tanegashima, Yukiko Sato-Miyata, Masabumi Funakoshi, Yasumasa Nishito, Toshiro Aigaki and Takahiko Hara

    Version of Record online: 9 DEC 2016 | DOI: 10.1111/gtc.12456

    Thumbnail image of graphical abstract

    In the mouse brain, fasting up-regulates the expression of glucose transporter gene, slc2a1. A fasting-induced metabolite, beta-hydroxybutyrate positively regulates the expression of slc2a1 in part by the inhibition of HDAC activity. Those mechanisms may contribute stable metabolism in the brain during fasting.

  2. CK2 phospho-independent assembly of the Tel2-associated stress-signaling complexes in Schizosaccharomyces pombe

    Haruna Inoue, Shizuka Sugimoto, Yumiko Takeshita, Miho Takeuchi, Mitsuko Hatanaka, Koji Nagao, Takeshi Hayashi, Aya Kokubu, Mitsuhiro Yanagida and Junko Kanoh

    Version of Record online: 9 DEC 2016 | DOI: 10.1111/gtc.12454

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    Schizosaccharomyces pombe Tel2 is phosphorylated by CK2 at Ser490 and Thr493. Tel2 forms the TTT complex with Tti1 and Tti2 and also associates with PIKKs, Rvb2 and Hsp90 in vivo; however, the phosphorylation of Tel2 affects neither the stability of the Tel2-associated proteins nor their association with Tel2.

  3. Coupling of a voltage-gated Ca2+ channel homologue with a plasma membrane H+-ATPase in yeast

    Toshihiko Cho, Aya Ishii-Kato, Yuko Fukata, Yoshitaka Nakayama, Kazuko Iida, Masaki Fukata and Hidetoshi Iida

    Version of Record online: 9 DEC 2016 | DOI: 10.1111/gtc.12458

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    Cch1/Mid1 calcium channel is a yeast homologue of mammalian voltage-gated calcium channels. In this report, we suggest that Mid1 physically interacts with Pma1, a plasma membrane H+-ATPase and that the H+-pumping activity of Pma1 is important for the activation of the Cch1/Mid1 calcium channel.

  4. MYB transcription factor gene involved in sex determination in Asparagus officinalis

    Kohji Murase, Shuji Shigenobu, Sota Fujii, Kazuki Ueda, Takanori Murata, Ai Sakamoto, Yuko Wada, Katsushi Yamaguchi, Yuriko Osakabe, Keishi Osakabe, Akira Kanno, Yukio Ozaki and Seiji Takayama

    Version of Record online: 21 NOV 2016 | DOI: 10.1111/gtc.12453

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    A MYB-like gene, MSE1, located on the Y chromosome and mutated on the X, acts in sex determination by inducing male-specific anther development in Asparagus officinalis.

  5. Structural and functional analysis of cyclophilin PpiB mutants supports an in vivo function not limited to prolyl isomerization activity

    Aggeliki Skagia, Eleni Vezyri, Markezina Sigala, Areti Kokkinou, Michael Karpusas, Anastasia Venieraki, Panagiotis Katinakis and Maria Dimou

    Version of Record online: 21 NOV 2016 | DOI: 10.1111/gtc.12452

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    Combination of enzymatic studies concerning the prolyl isomerase and chaperone activities of various PpiB cyclophilin mutants with structural analyses based on 3D models shows that various structural features, apart from the catalytic pocket, appear to be important for its inhibitory role in motility and biofilm formation.

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