Genes to Cells

Cover image for Vol. 21 Issue 9

Edited By: Mitsuhiro Yanagida

Impact Factor: 2.481

ISI Journal Citation Reports © Ranking: 2015: 85/165 (Genetics & Heredity); 123/187 (Cell Biology)

Online ISSN: 1365-2443

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Recently Published Articles

  1. Dendritic transport element of human arc mRNA confers RNA degradation activity in a translation-dependent manner

    Kensuke Ninomiya, Mutsuhito Ohno and Naoyuki Kataoka

    Version of Record online: 23 SEP 2016 | DOI: 10.1111/gtc.12439

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    The human arc DTE in 3′ UTR has mRNA-destabilizing activity independent of nonsense-mediated mRNA decay (NMD). Destabilizing activity of the arc DTE is dependent on translation.

  2. Highly multiplexed CRISPR-Cas9-nuclease and Cas9-nickase vectors for inactivation of hepatitis B virus

    Tetsushi Sakuma, Keiichi Masaki, Hiromi Abe-Chayama, Keiji Mochida, Takashi Yamamoto and Kazuaki Chayama

    Version of Record online: 23 SEP 2016 | DOI: 10.1111/gtc.12437

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    We have created highly multiplexed CRISPR-Cas9 nuclease and nickase vectors targeting critical regions of the hepatitis B virus (HBV) genome and evaluated their functionality and safety in HepG2 cells. Both vectors could effectively suppress HBV DNA and antigens, and the small number of off-target mutations detected by deep sequencing analysis was extremely rare. Thus, this study provides a proof-of-concept demonstration of CRISPR-Cas9-mediated HBV inactivation, potentially contributing to a well-designed therapeutic approach for curing HBV patients.

  3. DNA damage inhibits lateral root formation by up-regulating cytokinin biosynthesis genes in Arabidopsis thaliana

    La Ode Muhammad Muchdar Davis, Nobuo Ogita, Soichi Inagaki, Naoki Takahashi and Masaaki Umeda

    Version of Record online: 23 SEP 2016 | DOI: 10.1111/gtc.12436

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    Lateral roots (LRs) are an important organ for water and nutrient uptake from soil. However, the underlying mechanism controlling LR formation in response to external factors has remained largely unknown. In this study, we revealed that SOG1 transcription factor regulates DNA repair and cytokinin signaling separately and plays a key role in controlling LR formation under genotoxic stress.

  4. Development of mouse models of malignant phyllodes tumors by transplantation of syngeneic mammary gland cells expressing mutant H-Ras

    Yayoi Takamoto, Yoshimi Arima and Hideyuki Saya

    Version of Record online: 23 SEP 2016 | DOI: 10.1111/gtc.12435

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    Our work describes mouse models of malignant phyllodes tumors driven by the introduction of H-RasG12V. Mouse undifferentiated mammary gland cells were infected with a retrovirus encoding the human oncoprotein H-RasG12V. The infected cells were transplanted orthotopically into the mammary fat pads of syngeneic mice, and these transplanted cells formed tumors.

  5. Terminal differentiation of cortical neurons rapidly remodels RanGAP-mediated nuclear transport system

    Kazushiro Fujiwara, Koichi Hasegawa, Masahiro Oka, Yoshihiro Yoneda and Kazuaki Yoshikawa

    Version of Record online: 22 SEP 2016 | DOI: 10.1111/gtc.12434

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    RanGAP-mediated nuclear transport system is rapidly remodeled during neuronal terminal differentiation of cortical progenitor cells. SUMO-modified RanGAP undergoes desumoylation and degradation, which impedes the nuclear import of the DNA replication initiation factor Cdc6.