Genes to Cells

Cover image for Vol. 20 Issue 9

Edited By: Mitsuhiro Yanagida

Impact Factor: 2.805

ISI Journal Citation Reports © Ranking: 2014: 70/167 (Genetics & Heredity); 111/184 (Cell Biology)

Online ISSN: 1365-2443

Recently Published Issues

See all

Genes to Cells February CoverSee and read about our journal covers, each available as free pdf downloads.

Online Only news
Genes to Cells will be available online only from 2015. For more information and to receive electronic Table of Content alerts each time a new issue is published online, please see here.

Recently Published Articles

  1. 7-Ketocholesterol-induced lysosomal dysfunction exacerbates vascular smooth muscle cell calcification via oxidative stress

    Ryo Sudo, Fumiaki Sato, Takuya Azechi and Hiroshi Wachi

    Article first published online: 30 SEP 2015 | DOI: 10.1111/gtc.12301

    Thumbnail image of graphical abstract

    In our in vitro study, we demonstrated that the lysosomal-dysfunction-dependent oxidative stress played a pivotal role in the progression of vascular smooth muscle cells calcification by a low concentration of 7-ketocholesterol, and that even normal serum levels of 7-ketocholesterol can be a risk factor for vascular calcification.

  2. Genomic confirmation of nutrient-dependent mutability of mutators in Escherichia coli

    Saburo Tsuru, Yuuka Ishizawa, Atsushi Shibai, Yusuke Takahashi, Daisuke Motooka, Shota Nakamura and Tetsuya Yomo

    Article first published online: 28 SEP 2015 | DOI: 10.1111/gtc.12300

    Thumbnail image of graphical abstract

    We used two mutator strains of Escherichia coli to explore the nutrient dependence of mutation rates at the genomic level. These strains were transferred repeatedly under different nutritional conditions for hundreds of generations to accumulate mutations. Whole-genome sequencing of the offspring revealed that the nutrient dependence of the mutation rates was pervasive at the genomic scale.

  3. Escherichia coli inner membrane protein YciB interacts with ZipA that is important for cell division

    Noor Afiza Badaluddin and Madoka Kitakawa

    Article first published online: 22 SEP 2015 | DOI: 10.1111/gtc.12299

    Thumbnail image of graphical abstract

    Deletion mutant of yciB (ΔyciB) is shorter in the cell length compared to wild type and on the other hand an overexpression of yciB causes elongation of the cell. We also found that the septum localization of ZipA, an essential protein of cell division, was disturbed in ΔyciB mutant. Furthermore, purified YciB protein directly interacted with ZipA.

  4. You have full text access to this OnlineOpen article
    Functional specialization in regulation and quality control in thermal adaptive evolution

    Kazuma Yama, Yuki Matsumoto, Yoshie Murakami, Shigeto Seno, Hideo Matsuda, Kazuyoshi Gotoh, Daisuke Motooka, Shota Nakamura, Bei-Wen Ying and Tetsuya Yomo

    Article first published online: 15 SEP 2015 | DOI: 10.1111/gtc.12298

    Thumbnail image of graphical abstract

    Two highly comparable molecular mechanisms, rpoH-initiated gene regulation and chaperonin-initiated quality control, were selected by E. coli for survival during thermal adaptive evolution. Multilevel analyses revealed the thermal adaptive evolution favored fewer and localised changes in gene expression and protein folding. The results indicated a cost-saving strategy in both gene expression regulation and protein quality control, which may contribute to the overall homeostatic framework of cellular physiology.

  5. You have full text access to this OnlineOpen article
    Baton pass hypothesis: successive incorporation of unconserved endogenous retroviral genes for placentation during mammalian evolution

    Kazuhiko Imakawa, So Nakagawa and Takayuki Miyazawa

    Article first published online: 7 SEP 2015 | DOI: 10.1111/gtc.12278

    Thumbnail image of graphical abstract

    Mammalian placenta are diversified in their morphological appearances. Endogenous retroviruses have undoubtedly contributed to these placentas. We propose ‘baton pass’ hypothesis, in which different genes, but homologous functions, contributed to placental evolution.