Genes to Cells

Cover image for Vol. 21 Issue 7

Edited By: Mitsuhiro Yanagida

Impact Factor: 2.481

ISI Journal Citation Reports © Ranking: 2015: 85/165 (Genetics & Heredity); 123/187 (Cell Biology)

Online ISSN: 1365-2443

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Recently Published Articles

  1. Characterization of a homologue of mammalian serine racemase from Caenorhabditis elegans: the enzyme is not critical for the metabolism of serine in vivo

    Masumi Katane, Yuki Saitoh, Keita Uchiyama, Kazuki Nakayama, Yasuaki Saitoh, Tetsuya Miyamoto, Masae Sekine, Kouji Uda and Hiroshi Homma

    Version of Record online: 26 JUL 2016 | DOI: 10.1111/gtc.12398

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    A homologue (T01H8.2) of mammalian serine racemase from Caenorhabditis elegans was characterized. The results demonstrate that T01H8.2 shows dehydratase activity toward several hydroxyamino acids in addition to racemase activity. Furthermore, the enzyme does not appear to metabolize d- and l-serine in vivo.

  2. You have full text access to this OnlineOpen article
    ICRF-193, an anticancer topoisomerase II inhibitor, induces arched telophase spindles that snap, leading to a ploidy increase in fission yeast

    Norihiko Nakazawa, Rajesh Mehrotra, Orie Arakawa and Mitsuhiro Yanagida

    Version of Record online: 26 JUL 2016 | DOI: 10.1111/gtc.12397

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    ICRF-193 is an inhibitor of DNA topoisomerase II that is used as an effective anticancer drug. Here, we examined the effects of ICRF-193 treatment on chromatin behavior and spindle dynamics using detailed live mitotic cell analysis in the fission yeast, Schizosaccharomyces pombe. We demonstrated that ICRF-193-treated, unseparated sister chromatids pulling toward opposite spindle poles produce the ‘arched’ and ‘snapped’ unique telophase spindle, resulting in polyploidization.

  3. Chromosomal location of the DnaA-reactivating sequence DARS2 is important to regulate timely initiation of DNA replication in Escherichia coli

    Yukie Inoue, Hiroyuki Tanaka, Kazutoshi Kasho, Kazuyuki Fujimitsu, Taku Oshima and Tsutomu Katayama

    Version of Record online: 25 JUL 2016 | DOI: 10.1111/gtc.12395

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    The DnaA-reactivating sequence 2, DARS2, on the chromosome forms specific nucleoprotein complexes, producing replication-active ATP-DnaA from inactive ADP-DnaA. We found that the chromosomal location of DARS2 is relevant to the initiation regulation of replication.

  4. You have full text access to this OnlineOpen article
    Caenorhabditis elegans homologue of Prox1/Prospero is expressed in the glia and is required for sensory behavior and cold tolerance

    Eriko Kage-Nakadai, Akane Ohta, Tomoyo Ujisawa, Simo Sun, Yoshikazu Nishikawa, Atsushi Kuhara and Shohei Mitani

    Version of Record online: 12 JUL 2016 | DOI: 10.1111/gtc.12394

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    We performed RNA interference (RNAi) screening for transcription factors that regulate the expression of an amphid sheath glial cell marker and identified pros-1, which encodes a homeodomain transcription factor homologous to Drosophila prospero/mammalian Prox1, as a positive regulator. The functional PROS-1::EGFP fusion protein was localized in the nuclei of the glia and the excretory cell but not in the amphid sensory neurons. We further found that the structure and functions of sensory neurons, such as the morphology of sensory endings, sensory behavior and sensory-mediated cold tolerance, appeared to be affected by pros-1 RNAi.

  5. NEK6-mediated phosphorylation of human TPP1 regulates telomere length through telomerase recruitment

    Yugo Hirai, Miki Tamura, Junji Otani and Fuyuki Ishikawa

    Version of Record online: 11 JUL 2016 | DOI: 10.1111/gtc.12391

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    Human telomere protein TPP1 is phosphorylated in G2/M-phase cells by NEK6 kinase to regulate telomerase reactions.