Genes to Cells

Cover image for Vol. 23 Issue 1

Edited By: Mitsuhiro Yanagida

Impact Factor: 1.993

ISI Journal Citation Reports © Ranking: 2016: 107/167 (Genetics & Heredity); 147/190 (Cell Biology)

Online ISSN: 1365-2443

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Recently Published Articles

  1. Transgenic mice specifically expressing amphiregulin in white adipose tissue showed less adipose tissue mass

    Bo Yang, Takahiro Kumoto, Takeshi Arima, Minako Nakamura, Yohei Sanada, Thanutchaporn Kumrungsee, Yusuke Sotomaru, Masayuki Shimada and Noriyuki Yanaka

    Version of Record online: 17 JAN 2018 | DOI: 10.1111/gtc.12558

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    Areg mRNA expression was significantly up-regulated in mouse obese adipose tissues, and over-expression of Areg in white adipose tissue caused less adipose tissue mass.

  2. MicroRNA-664a-5p promotes neuronal differentiation of SH-SY5Y cells

    Kazunori Watanabe, Ryuhei Yamaji and Takashi Ohtsuki

    Version of Record online: 17 JAN 2018 | DOI: 10.1111/gtc.12559

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    miR-664a-5p promoted neuronal differentiation.

  3. Identification of miR-305, a microRNA that promotes aging, and its target mRNAs in Drosophila

    Makiko Ueda, Tetsuya Sato, Yasuyuki Ohkawa and Yoshihiro H. Inoue

    Version of Record online: 5 JAN 2018 | DOI: 10.1111/gtc.12555

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    We showed that miR-305 overexpression leads to a short lifespan and enhances the age-dependent loss of locomotor activity, the accumulation of poly-ubiquitinated protein aggregates in the flight muscles and the sensitivity to oxidative stress, whereas reduced miR-305 expression leads to an extended lifespan and suppresses the age-dependent loss of locomotor activity, the accumulation of poly-ubiquitinated protein aggregates and the sensitivity to oxidative stress in Drosophila. These findings indicate that miR-305 influences the progression of aging in Drosophila. Moreover, we identified candidate target mRNAs for miR-305, such as the mRNA of several antimicrobial peptides.

  4. Suppression of targeting of Dbf4-dependent kinase to pre-replicative complex in G0 nuclei

    Takuya Okada, Gaku Okabe, Yon-Soo Tak, Satoru Mimura, Haruhiko Takisawa and Yumiko Kubota

    Version of Record online: 4 JAN 2018 | DOI: 10.1111/gtc.12556

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    Intact G0 nuclei isolated from quiescent cells are not capable of DNA replication in interphase Xenopus egg extracts. We showed that pre-RC is assembled on chromatin, but its activation is inhibited in the G0 nuclei because Mcm4 phosphorylation by DDK is suppressed in G0 nuclei. We suggested that the nuclear extracts of G0 contain the factor(s) to prevent the targeting of DDK to pre-RC, thereby suppressing DNA replication in Xenopus egg extracts.

  5. You have full text access to this OnlineOpen article
    Lem2 is retained at the nuclear envelope through its interaction with Bqt4 in fission yeast

    Yasuhiro Hirano, Yasuha Kinugasa, Haruhiko Asakawa, Yuji Chikashige, Chikashi Obuse, Tokuko Haraguchi and Yasushi Hiraoka

    Version of Record online: 2 JAN 2018 | DOI: 10.1111/gtc.12557

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    The localization of Lem2 to the NE is promoted through its interaction with Bqt4. Lem2 and Bqt4 play cooperative roles at the NE, that are important for cell viability, but the Lem2-Bqt4 interaction appears unnecessary for the cell viability. Thus, Lem2 and Bqt4 seem to act separately through independent pathways.