Genes to Cells
© The Molecular Biology Society of Japan/John Wiley & Sons Australia, Ltd
Edited By: Mitsuhiro Yanagida
Impact Factor: 2.481
ISI Journal Citation Reports © Ranking: 2015: 85/166 (Genetics & Heredity); 123/187 (Cell Biology)
Online ISSN: 1365-2443
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Recently Published Articles
- Behavioral and neuroanatomical analyses in a genetic mouse model of 2q13 duplication
Keiko Kishimoto, Jun Nomura, Jacob Ellegood, Keita Fukumoto, Jason P. Lerch, Daniel Moreno-De-Luca, Thomas Bourgeron, Kota Tamada and Toru Takumi
Version of Record online: 29 MAR 2017 | DOI: 10.1111/gtc.12487
We generated bacterial artificial chromosome-based transgenic mice, called 2q13 dup, that recapitulate human chromosome 2q13 duplication and contain one extra copy of the Nphp1 transgene. Although 2q13 dup mice show no significant differences in social behavior, they display deficits in spontaneous alternation behavior and fear memory. MRI shows a trend towards a decrease in the cerebellar paraflocculus of 2q13 dup mice.
- HIV-1 susceptibility of transgenic rat-derived primary macrophage/T cells and a T cell line that express human receptors, CyclinT1 and CRM1 genes
Hisatoshi Shida, Hiroyuki Okada, Hajime Suzuki, Xianfeng Zhang, Jing Chen, Yasuko Tsunetsugu-Yokota, Yuetsu Tanaka, Fumika Yakushiji and Yoshio Hayashi
Version of Record online: 22 MAR 2017 | DOI: 10.1111/gtc.12486
Tg rats that express human CD4, CCR5, CXCR4, CycT1, and CRM1 were created. Tg rat macrophages support propagation of HIV-1. Tg CD4 T cells are still refractory to the infection, which is partially rescued by inhibiting function of cyclophilin A.
- Chromatin tethering to the nuclear envelope by nuclear actin filaments: a novel role of the actin cytoskeleton in the Xenopus blastula
Haruka Oda, Natsuki Shirai, Naoko Ura, Keita Ohsumi and Mari Iwabuchi
Version of Record online: 20 MAR 2017 | DOI: 10.1111/gtc.12483
While nuclear F-actin accumulates in Xenopus oocytes, it is unknown whether it does so in embryos. Using fluorescence-labeled actin reporters and Xenopus egg extracts, we demonstrate that F-actin accumulates in blastula nuclei, promoting chromatin–nuclear envelope binding, nuclear structural stability and M-phase mitotic chromosome alignment.
- Thymine DNA glycosylase modulates DNA damage response and gene expression by base excision repair-dependent and independent mechanisms
Tomohumi Nakamura, Kouichi Murakami, Haruto Tada, Yoshihiko Uehara, Jumpei Nogami, Kazumitsu Maehara, Yasuyuki Ohkawa, Hisato Saitoh, Hideo Nishitani, Tetsuya Ono, Ryotaro Nishi, Masayuki Yokoi, Wataru Sakai and Kaoru Sugasawa
Version of Record online: 20 MAR 2017 | DOI: 10.1111/gtc.12481
- Dickkopf 3 attenuates xanthine dehydrogenase expression to prevent oxidative stress-induced apoptosis
Shuang Qui, Junko Kano and Masayuki Noguchi
Version of Record online: 15 MAR 2017 | DOI: 10.1111/gtc.12484
DKK3 promotes cell survival during oxidative stress by suppressing the expression of the superoxide-producing enzyme XDH.