Genes to Cells

Cover image for Vol. 20 Issue 8

Edited By: Mitsuhiro Yanagida

Impact Factor: 2.805

ISI Journal Citation Reports © Ranking: 2014: 70/167 (Genetics & Heredity); 111/184 (Cell Biology)

Online ISSN: 1365-2443

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Recently Published Articles

  1. Expanded roles of two-component response regulator OmpR in Escherichia coli: genomic SELEX search for novel regulation targets

    Tomohiro Shimada, Hiraku Takada, Kaneyoshi Yamamoto and Akira Ishihama

    Article first published online: 2 SEP 2015 | DOI: 10.1111/gtc.12282

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    Using Genomic SELEX screening system, more than 30 novel regulation targets have been identified for the two-component response regulator OmpR in Escherichia coli.

  2. Structural analysis of the mechanism of phosphorylation of a critical autoregulatory tyrosine residue in FGFR1 kinase domain

    Yoshihiro Kobashigawa, Shinjiro Amano, Mariko Yokogawa, Hiroyuki Kumeta, Hiroshi Morioka, Masayori Inouye, Joseph Schlessinger and Fuyuhiko Inagaki

    Article first published online: 24 AUG 2015 | DOI: 10.1111/gtc.12277

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    Trans-phosphorylation of Tyr residue in the activation-loop of receptor tyrosine kinases is a key step in triggering cellular signal transduction pathway. Here, the molecular mechanism underlying the control of trans-phosphorylation of a critical auto-regulatory site in FGF receptors catalytic domain was elucidated by NMR analysis.

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    MT1-MMP recognition by ERM proteins and its implication in CD44 shedding

    Shin-ichi Terawaki, Ken Kitano, Miki Aoyama, Tomoyuki Mori and Toshio Hakoshima

    Article first published online: 20 AUG 2015 | DOI: 10.1111/gtc.12276

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    Structural and physical data showed that radixin simultaneously binds both MT1-MMP and CD44, indicating ERM protein-mediated colocalization of MT1-MMP and its substrate CD44 and anchoring to F-actin. Our study implies that ERM proteins contribute towards accelerated CD44 shedding by MT1-MMP through ERM protein-mediated interactions between their cytoplasmic tails.

  4. Role of 100S ribosomes in bacterial decay period

    Ksenia Shcherbakova, Hideki Nakayama and Nobuo Shimamoto

    Article first published online: 20 AUG 2015 | DOI: 10.1111/gtc.12273

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    Microscopic images of ribosomes with chromosomal rpsJ fused with B-maggio gfp at 6 h (top) and at 60 h (bottom).