Genes to Cells
© The Molecular Biology Society of Japan/Wiley Publishing Asia Pty Ltd.
Edited By: Mitsuhiro Yanagida
Impact Factor: 2.805
ISI Journal Citation Reports © Ranking: 2014: 70/167 (Genetics & Heredity); 111/184 (Cell Biology)
Online ISSN: 1365-2443
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Recently Published Articles
- Distal regulatory element of the STAT1 gene potentially mediates positive feedback control of STAT1 expression
Katsutoshi Yuasa and Takao Hijikata
Article first published online: 23 NOV 2015 | DOI: 10.1111/gtc.12316
A novel distal regulatory element 5.5URR could mediate positive feedback regulation of the STAT1 gene expression. Through this autoregulation, the 5.5URR could also contribute to the amplification and/or prolongation of intracellular IFN signals.
- Effects of 6-meals-a-day feeding and 6-meals-a-day feeding combined with adrenalectomy on daily gene expression rhythms in rat epididymal white adipose tissue
Yan Su, Ewout Foppen, Zhi Zhang, Eric Fliers and Andries Kalsbeek
Article first published online: 15 NOV 2015 | DOI: 10.1111/gtc.12315
We investigated the importance of adrenal hormones and a daily feeding rhythm as rhythmic outputs of the biological clock to synchronize day/night rhythms in (clock) gene expression in white adipose tissue (WAT). We found that at least one of these two outputs should be present in order for WAT clock gene rhythms to be maintained.
- Relative contribution of four nucleases, CtIP, Dna2, Exo1 and Mre11, to the initial step of DNA double-strand break repair by homologous recombination in both the chicken DT40 and human TK6 cell lines
Nguyen Ngoc Hoa, Remi Akagawa, Tomomi Yamasaki, Kouji Hirota, Kentaro Sasa, Toyoaki Natsume, Junya Kobayashi, Tetsushi Sakuma, Takashi Yamamoto, Kenshi Komatsu, Masato T. Kanemaki, Yves Pommier, Shunichi Takeda and Hiroyuki Sasanuma
Article first published online: 2 NOV 2015 | DOI: 10.1111/gtc.12310
Using genome-editing technology, we here engineered the nuclease mutants of human TK6 cell line, which are involved in DNA double-strand break repair. Among the mutants, we found that CtIP and Dna2 predominantly function in the process of DSB resection to ensure efficient DSB repair by HR in human cells.
- You have full text access to this OnlineOpen articleCasein kinase 1γ acts as a molecular switch for cell polarization through phosphorylation of the polarity factor Tea1 in fission yeast
Takayuki Koyano, Karin Barnouin, Ambrosius P. Snijders, Kazunori Kume, Dai Hirata and Takashi Toda
Article first published online: 2 NOV 2015 | DOI: 10.1111/gtc.12309
When Tea1 is entrapped by Cki3 to the cell membrane, Tea1 is hyperphosphorylated, thereby becoming inactive for the potentiation of growth from the cell tip. Under this condition, interaction between Tea1 and Tea4 is compromised. Phosphomimetic Tea1 recapitulates the nongrowth phenotype.
- Microphthalmia-associated transcription factor is expressed in projection neurons of the mouse olfactory bulb
Koji Ohba, Kazuhisa Takeda, Hiroaki Yamamoto and Shigeki Shibahara
Article first published online: 2 NOV 2015 | DOI: 10.1111/gtc.12312
Immunohistochemical analysis of the olfactory bulb (OB) revealed that Mitf-positive cells were detected near the glomerular layer (GL) and in the mitral cell layer (MCL). Arrowheads indicate the two types of Mitf-positive cells: mitral cells (closed arrowheads) and tufted cells (open arrowheads).