Genes to Cells

Cover image for Vol. 20 Issue 3

Edited By: Mitsuhiro Yanagida

Impact Factor: 2.855

ISI Journal Citation Reports © Ranking: 2013: 70/165 (Genetics & Heredity); 108/185 (Cell Biology)

Online ISSN: 1365-2443

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Recently Published Articles

  1. Dendritic cell SIRPα regulates homeostasis of dendritic cells in lymphoid organs

    Ken Washio, Takenori Kotani, Yasuyuki Saito, Datu Respatika, Yoji Murata, Yoriaki Kaneko, Hideki Okazawa, Hiroshi Ohnishi, Atsushi Fukunaga, Chikako Nishigori and Takashi Matozaki

    Article first published online: 27 MAR 2015 | DOI: 10.1111/gtc.12238

  2. White spotting phenotype induced by targeted REST disruption during neural crest specification to a melanocyte cell lineage

    Hitomi Aoki, Akira Hara and Takahiro Kunisada

    Article first published online: 27 MAR 2015 | DOI: 10.1111/gtc.12235

    Thumbnail image of graphical abstract

    The transcriptional repressor RE1-silencing transcription factor (REST), also known as neuron-restrictive silencer factor (NRSF), acts as a negative regulator of neuron-specific genes. While Rest null mice die by E11.5 days with hypoplastic morphological changes, neural crest cell-specific Rest conditional knockout (CKO) mice showed the neonatal death due to swelling of the digestive tract, and the downregulation of acetylcholinesterase activity in the NCC-derived myenteric plexus in the stomach. Here, we generated a viable heterozygote of Rest CKO mice and identified their white spotting phenotype and corresponding localized reduction in skin melanoblasts, suggesting the involvement of Rest in the early melanocyte specification stage.

  3. Notch signaling regulates venous arterialization during zebrafish fin regeneration

    Yoshiko Kametani, Neil C. Chi, Didier Y.R. Stainier and Shinji Takada

    Article first published online: 25 MAR 2015 | DOI: 10.1111/gtc.12234

    Thumbnail image of graphical abstract

    During regeneration of the zebrafish caudal fin, vein-derived cells contributed to the reconstructed arteries. Furthermore, the initiation of this arterialization was dependent on Notch signaling.

  4. Alcohol dehydrogenase 3 contributes to the protection of liver from nonalcoholic steatohepatitis

    Maki Goto, Hiroshi Kitamura, Md. Morshedul Alam, Nao Ota, Takeshi Haseba, Toshio Akimoto, Akio Shimizu, Teruko Takano-Yamamoto, Masayuki Yamamoto and Hozumi Motohashi

    Article first published online: 16 MAR 2015 | DOI: 10.1111/gtc.12237

    Thumbnail image of graphical abstract

    ADH3 is a highly conserved bifunctional enzyme involved in formaldehyde detoxification and termination of nitric oxide signaling. We found that ADH3 protects liver from steatosis independently of NRF2 and prevents the progression of the steatosis into steatohepatitis in cooperation with NRF2.

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    Mef2d is essential for the maturation and integrity of retinal photoreceptor and bipolar cells

    Yoshihiro Omori, Tamiki Kitamura, Satoyo Yoshida, Ryusuke Kuwahara, Taro Chaya, Shoichi Irie and Takahisa Furukawa

    Article first published online: 11 MAR 2015 | DOI: 10.1111/gtc.12233