Genes to Cells

Cover image for Vol. 22 Issue 11

Edited By: Mitsuhiro Yanagida

Impact Factor: 1.993

ISI Journal Citation Reports © Ranking: 2016: 107/167 (Genetics & Heredity); 147/190 (Cell Biology)

Online ISSN: 1365-2443

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Recently Published Articles

  1. Impaired p53/CEP-1 is associated with lifespan extension through an age-related imbalance in the energy metabolism of C. elegans

    Sumino Yanase, Hitoshi Suda, Kayo Yasuda and Naoaki Ishii

    Version of Record online: 8 NOV 2017 | DOI: 10.1111/gtc.12540

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    Here, we examined that intermittent exposure to hyperoxia slightly improved the lifespan extension of cep-1 mutant, which deletes the mammalian tumor suppressor p53 ortholog gene, and found that the ATP levels were increased without an increase in oxygen consumption in cep-1 mutant during aging. In the wild-type, expression of sco-1 gene that is a target of p53/CEP-1 increased, and lactate levels and consequentially the lactate/pyruvate ratio decreased during aging. These results suggest that impaired p53/CEP-1 leads to an imbalance in the age-related energy metabolic alteration between mitochondrial oxidative phosphorylation and aerobic glycolysis and plays an important role in the extension of both intact and adaptive lifespans.

  2. cAMP-induced activation of protein kinase A and p190B RhoGAP mediates down-regulation of TC10 activity at the plasma membrane and neurite outgrowth (pages 953–967)

    Shingo Koinuma, Kohei Takeuchi, Naoyuki Wada and Takeshi Nakamura

    Version of Record online: 26 OCT 2017 | DOI: 10.1111/gtc.12538

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    Here, we demonstrated that cAMP-induced down-regulation of plasmalemmal TC10 and RhoA in neuronal cell lines is mediated by the PKA-STEF-Rac1-p190B pathway. The concurrent inactivation of TC10 and RhoA can be implicated in neurite outgrowth through membrane addition and a decrease in F-actin contractility.

  3. Induction of erythropoietin gene expression in epithelial cells by chemicals identified in GATA inhibitor screenings (pages 939–952)

    Hiroshi Kaneko, Takehide Katoh, Ikuo Hirano, Atsushi Hasegawa, Tadayuki Tsujita, Masayuki Yamamoto and Ritsuko Shimizu

    Version of Record online: 18 OCT 2017 | DOI: 10.1111/gtc.12537

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    Mitoxantrone and its analogues markedly induce EPO/Epo gene expression in epithelium-derived cell lines and mice regardless of oxygen levels. EPO production in uninjured adult epithelial cells may be a therapeutic approach for renal anemia in patients with CKD.

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    Hikeshi modulates the proteotoxic stress response in human cells: Implication for the importance of the nuclear function of HSP70s (pages 968–976)

    Khondoker Md Zulfiker Rahman, Hiroshi Mamada, Masatoshi Takagi, Shingo Kose and Naoko Imamoto

    Version of Record online: 5 OCT 2017 | DOI: 10.1111/gtc.12536

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    We found that Hikeshi is required for the survival of HeLa cells in response to proteotoxic stress, but depletion of Hikeshi increases the survival of hTERT-RPE1 cells. Depletion of Hikeshi renders HeLa cells proteotoxic stress-sensitive through the abrogation of the nuclear function of HSP70s required for HSF1 regulation. In addition, we found Hikeshi-depleted hTERT-RPE1 upregulates p21, which could be one cause of its proteotoxic stress resistance.

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    Elucidation of GlcNAc-binding properties of type III intermediate filament proteins, using GlcNAc-bearing polymers (pages 900–917)

    Hirohiko Ise, Sadanori Yamasaki, Kazuaki Sueyoshi and Yoshiko Miura

    Version of Record online: 12 SEP 2017 | DOI: 10.1111/gtc.12535

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    Confocal laser scanning images show the interactions of cell surface-expressed vimentin with GlcNAc-bearing polymers and the localization of caveolin-1 on HeLa cells.