Genes to Cells
© The Molecular Biology Society of Japan/John Wiley & Sons Australia, Ltd
Edited By: Mitsuhiro Yanagida
Impact Factor: 2.481
ISI Journal Citation Reports © Ranking: 2015: 85/165 (Genetics & Heredity); 123/187 (Cell Biology)
Online ISSN: 1365-2443
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Recently Published Articles
- You have full text access to this OnlineOpen articleCaenorhabditis elegans homologue of Prox1/Prospero is expressed in the glia and is required for sensory behavior and cold tolerance
Eriko Kage-Nakadai, Akane Ohta, Tomoyo Ujisawa, Simo Sun, Yoshikazu Nishikawa, Atsushi Kuhara and Shohei Mitani
Version of Record online: 12 JUL 2016 | DOI: 10.1111/gtc.12394
We performed RNA interference (RNAi) screening for transcription factors that regulate the expression of an amphid sheath glial cell marker and identified pros-1, which encodes a homeodomain transcription factor homologous to Drosophila prospero/mammalian Prox1, as a positive regulator. The functional PROS-1::EGFP fusion protein was localized in the nuclei of the glia and the excretory cell but not in the amphid sensory neurons. We further found that the structure and functions of sensory neurons, such as the morphology of sensory endings, sensory behavior and sensory-mediated cold tolerance, appeared to be affected by pros-1 RNAi.
- NEK6-mediated phosphorylation of human TPP1 regulates telomere length through telomerase recruitment
Yugo Hirai, Miki Tamura, Junji Otani and Fuyuki Ishikawa
Version of Record online: 11 JUL 2016 | DOI: 10.1111/gtc.12391
Human telomere protein TPP1 is phosphorylated in G2/M-phase cells by NEK6 kinase to regulate telomerase reactions.
- Balance between cAMP and Ca2+ signals regulates expression levels of pituitary adenylate cyclase-activating polypeptide gene in neurons
Mamoru Fukuchi, Yuki Kuwana, Akiko Tabuchi and Masaaki Tsuda
Version of Record online: 7 JUL 2016 | DOI: 10.1111/gtc.12393
Ca2+ signaling evoked by excitatory neurotransmission not only activates the Pacap promoter but also prevents Pacap mRNA degradation. In contrast, cAMP signals, which can be induced by Gs-coupled GPCR activation, reduce the expression levels of Pacap mRNA. However, cAMP signals also participate in the synergistic induction of Pacap in the presence of Ca2+ signals via calcineurin/CRTC1/CREB, resulting in robust PACAP expression in neurons.
- Fluorescent-based evaluation of chaperone-mediated autophagy and microautophagy activities in cultured cells
Masahiro Sato, Takahiro Seki, Ayumu Konno, Hirokazu Hirai, Yuki Kurauchi, Akinori Hisatsune and Hiroshi Katsuki
Version of Record online: 5 JUL 2016 | DOI: 10.1111/gtc.12390
We established a novel method to monitor the activities of chaperone-mediated autophagy and microautophagy, separately, in cultured cell lines and primary cultured neurons.
- Targeting ID2 expression triggers a more differentiated phenotype and reduces aggressiveness in human salivary gland cancer cells
Tomoki Sumida, Akiko Ishikawa, Hiroyuki Nakano, Tomohiro Yamada, Yoshihide Mori and Pierre-Yves Desprez
Version of Record online: 1 JUL 2016 | DOI: 10.1111/gtc.12389
Inhibitors of DNA binding (ID) proteins are negative regulators of basic helix-loop-helix transcription factors, and generally stimulate cell proliferation and inhibit differentiation. ID2 knockdown triggers important changes in cell behavior, that is, it significantly reduces the expression of N-cadherin, vimentin and Snail, induces E-cadherin expression, and leads to a more differentiated phenotype exemplified by changes in cell shape. ID2 therefore represents a potential therapeutic target during salivary gland cancer progression. HSG, human salivary gland.