Genes to Cells

Cover image for Vol. 23 Issue 2

Edited By: Mitsuhiro Yanagida

Impact Factor: 1.993

ISI Journal Citation Reports © Ranking: 2016: 107/167 (Genetics & Heredity); 147/190 (Cell Biology)

Online ISSN: 1365-2443

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Recently Published Articles

  1. You have full text access to this OnlineOpen article
  2. Aggregatibacter actinomycetemcomitans infection causes DNA double-strand breaks in host cells

    Rie Teshima, Katsuhiro Hanada, Junko Akada, Kenji Kawano and Yoshio Yamaoka

    Version of Record online: 14 FEB 2018 | DOI: 10.1111/gtc.12570

    Thumbnail image of graphical abstract

    DNA double-strand breaks were accumulated in host cell after infection with A. actinomycetemcomitans Y4. The accumulation of DSBs following infection with A. actinomycetemcomitans was independent of apoptotic chromosomal fragmentation. A. actinomycetemcomitans infection induces inflammatory responses in host cells.

  3. Roles of the third Ig-like domain of Necl-5/PVR and the fifth Ig-like domain of the PDGF receptor in its signaling

    Yuki Ueda, Shin Kedashiro, Masahiro Maruoka, Kiyohito Mizutani and Yoshimi Takai

    Version of Record online: 12 FEB 2018 | DOI: 10.1111/gtc.12564

    Thumbnail image of graphical abstract

    Ueda et al. show that the third Ig-like domain of Necl-5 cis-interacts with the fifth Ig-like domain of the PDGF receptor β. Moreover, they show that the recombinant protein of the third Ig-like domain of Necl-5 inhibits the cis-interaction of full-length Necl-5 with the PDGF receptor β and the PDGF-induced activation of the ERK signaling pathway that is enhanced by Necl-5. These results revealed the roles of the third Ig-like domain of Necl-5 and the fifth Ig-like domain of the PDGF receptor β in its signaling.

  4. Wingless signaling regulates winner/loser status in Minute cell competition

    Nanami Akai, Tatsushi Igaki and Shizue Ohsawa

    Version of Record online: 12 FEB 2018 | DOI: 10.1111/gtc.12568

    Thumbnail image of graphical abstract

    We established two assay systems for Minute cell competition, namely the CORE system and the SURE system. Using these systems, we found that Wingless signaling regulates winner/loser status in Minute cell competition.

  5. Requirement of the F-actin-binding activity of l-afadin for enhancing the formation of adherens and tight junctions

    Shotaro Sakakibara, Tomohiko Maruo, Muneaki Miyata, Kiyohito Mizutani and Yoshimi Takai

    Version of Record online: 12 FEB 2018 | DOI: 10.1111/gtc.12566

    Thumbnail image of graphical abstract

    We found that the genetic ablation of the nectin-binding protein afadin in cultured EpH4 mouse mammary epithelial cells led to the delayed formation of adherens junctions (AJs) and tight junctions (TJs) in the calcium switch assay. In addition, we found that the F-actin-binding domain of l-afadin was required for the efficient formation of AJs and TJs. These results indicate that the F-actin-binding activity of l-afadin is required for enhancing the formation of both AJs and TJs.

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