Genes to Cells

Cover image for Vol. 20 Issue 5

Edited By: Mitsuhiro Yanagida

Impact Factor: 2.855

ISI Journal Citation Reports © Ranking: 2013: 70/165 (Genetics & Heredity); 108/185 (Cell Biology)

Online ISSN: 1365-2443

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Recently Published Articles

  1. Cross talk in promoter recognition between six NarL-family response regulators of Escherichia coli two-component system

    Myu Yoshida, Akira Ishihama and Kaneyoshi Yamamoto

    Article first published online: 26 MAY 2015 | DOI: 10.1111/gtc.12251

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    Cross talk of bacterial two-component system takes place at three stages: signal recognition by sensor kinase (stage-1); response regulator phosphorylation by sensor kinase (stage-2); and target recognition by response regulator (stage-3).

  2. Heme-mediated inhibition of Bach1 regulates the liver specificity and transience of the Nrf2-dependent induction of zebrafish heme oxygenase 1

    Yuji Fuse, Hitomi Nakajima, Yaeko Nakajima-Takagi, Osamu Nakajima and Makoto Kobayashi

    Article first published online: 18 MAY 2015 | DOI: 10.1111/gtc.12249

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    We previously showed the Nrf2-mediated induction of the zebrafish heme oxygenase 1 gene (hmox1a) to be liver-specific and transient. We herein identified that a factor governing this regulation is Bach1 (Bach1a and Bach1b in zebrafish) and heme mediates this regulation through Bach1 inhibition based on its level in each tissue.

  3. Discovery of an NRF1-specific inducer from a large-scale chemical library using a direct NRF1-protein monitoring system

    Tadayuki Tsujita, Liam Baird, Yuki Furusawa, Fumiki Katsuoka, Yoshika Hou, Satomi Gotoh, Shin-ichi Kawaguchi and Masayuki Yamamoto

    Article first published online: 4 MAY 2015 | DOI: 10.1111/gtc.12248

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    To develop an NRF1-specific inducer which could be used to understand the role of NRF1 within the cell. We developed a novel NRF1▵C-Luc fusion protein probe and stably expressed cell-line, Hepa:N1▵C-Luc reporter system. Through HTS using this cell line, we have successfully identified the first small compound which specifically stabilizes NRF1.

  4. You have full text access to this OnlineOpen article
    Phenotype-based clustering of glycosylation-related genes by RNAi-mediated gene silencing

    Miki Yamamoto-Hino, Hideki Yoshida, Tomomi Ichimiya, Sho Sakamura, Megumi Maeda, Yoshinobu Kimura, Norihiko Sasaki, Kiyoko F. Aoki-Kinoshita, Akiko Kinoshita-Toyoda, Hidenao Toyoda, Ryu Ueda, Shoko Nishihara and Satoshi Goto

    Article first published online: 4 MAY 2015 | DOI: 10.1111/gtc.12246

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    A large scale knockdown of glycosylation-related (GR) genes provided phenotypic clustering of the GR genes.

  5. Disappearance of centroacinar cells in the Notch ligand-deficient pancreas

    Yasuhiro Nakano, Naoko Negishi, Seiho Gocho, Tetsuya Mine, Yuri Sakurai, Masaki Yazawa, Koichiro Abe, Hideo Yagita, Sonoko Habu, Ryoichiro Kageyama, Yoshiya Kawaguchi and Katsuto Hozumi

    Article first published online: 27 APR 2015 | DOI: 10.1111/gtc.12243

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    Combined depletion of Dll1 and Jag1 caused loss of centroacinar/terminal duct cells. We propose machinery for acinar construction in which Notch plays a pivotal role. Reduced Sox9 expression was observed in Dll1/Jag1-doubly deficient mutants.