Genes to Cells

Cover image for Vol. 22 Issue 3

Edited By: Mitsuhiro Yanagida

Impact Factor: 2.481

ISI Journal Citation Reports © Ranking: 2015: 85/166 (Genetics & Heredity); 123/187 (Cell Biology)

Online ISSN: 1365-2443

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Recently Published Articles

  1. HIV-1 susceptibility of transgenic rat-derived primary macrophage/T cells and a T cell line that express human receptors, CyclinT1 and CRM1 genes

    Hisatoshi Shida, Hiroyuki Okada, Hajime Suzuki, Xianfeng Zhang, Jing Chen, Yasuko Tsunetsugu-Yokota, Yuetsu Tanaka, Fumika Yakushiji and Yoshio Hayashi

    Version of Record online: 22 MAR 2017 | DOI: 10.1111/gtc.12486

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    Tg rats that express human CD4, CCR5, CXCR4, CycT1, and CRM1 were created. Tg rat macrophages support propagation of HIV-1. Tg CD4 T cells are still refractory to the infection, which is partially rescued by inhibiting function of cyclophilin A.

  2. Chromatin tethering to the nuclear envelope by nuclear actin filaments: a novel role of the actin cytoskeleton in the Xenopus blastula

    Haruka Oda, Natsuki Shirai, Naoko Ura, Keita Ohsumi and Mari Iwabuchi

    Version of Record online: 20 MAR 2017 | DOI: 10.1111/gtc.12483

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    While nuclear F-actin accumulates in Xenopus oocytes, it is unknown whether it does so in embryos. Using fluorescence-labeled actin reporters and Xenopus egg extracts, we demonstrate that F-actin accumulates in blastula nuclei, promoting chromatin–nuclear envelope binding, nuclear structural stability and M-phase mitotic chromosome alignment.

  3. Thymine DNA glycosylase modulates DNA damage response and gene expression by base excision repair-dependent and independent mechanisms

    Tomohumi Nakamura, Kouichi Murakami, Haruto Tada, Yoshihiko Uehara, Jumpei Nogami, Kazumitsu Maehara, Yasuyuki Ohkawa, Hisato Saitoh, Hideo Nishitani, Tetsuya Ono, Ryotaro Nishi, Masayuki Yokoi, Wataru Sakai and Kaoru Sugasawa

    Version of Record online: 20 MAR 2017 | DOI: 10.1111/gtc.12481

  4. Dickkopf 3 attenuates xanthine dehydrogenase expression to prevent oxidative stress-induced apoptosis

    Shuang Qui, Junko Kano and Masayuki Noguchi

    Version of Record online: 15 MAR 2017 | DOI: 10.1111/gtc.12484

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    DKK3 promotes cell survival during oxidative stress by suppressing the expression of the superoxide-producing enzyme XDH.

  5. Geminin is an indispensable inhibitor of Cdt1 in mouse embryonic stem cells

    Masaki Hosogane, Lena Bosu, Emiko Fukumoto, Hidetoshi Yamada, Soichiro Sato and Keiko Nakayama

    Version of Record online: 14 MAR 2017 | DOI: 10.1111/gtc.12482

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    We established conditional knockout of Geminin in mouse ESCs and mouse embryonic fibroblasts. Geminin KO ESCs develop polyploidy accompanied by DNA damage and G2-M checkpoint activation, but MEFs do manifest disturbance of the cell cycle. Geminin is a key inhibitor of Cdt1 in mouse ESCs, but that it plays a backup role in MEFs to compensate for accidental up-regulation of Cdt1.