Genes to Cells

Cover image for Vol. 20 Issue 7

Edited By: Mitsuhiro Yanagida

Impact Factor: 2.805

ISI Journal Citation Reports © Ranking: 2014: 70/167 (Genetics & Heredity); 111/184 (Cell Biology)

Online ISSN: 1365-2443

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Recently Published Articles

  1. hCAS/CSE1L regulates RAD51 distribution and focus formation for homologous recombinational repair

    Satoshi Okimoto, Jiying Sun, Atsuhiko Fukuto, Yasunori Horikoshi, Shun Matsuda, Tomonari Matsuda, Masae Ikura, Tsuyoshi Ikura, Shinichi Machida, Hitoshi Kurumizaka, Yoichi Miyamoto, Masahiro Oka, Yoshihiro Yoneda, Yoshiaki Kiuchi and Satoshi Tashiro

    Article first published online: 30 JUN 2015 | DOI: 10.1111/gtc.12262

    Thumbnail image of graphical abstract

    We found that hCAS/CSE1L regulates the nuclear concentration of RAD51 and nuclear RAD51 focus formation. hCAS/CSE1L was required to repress the HR activity and to keep chromosome stability. These findings suggest that hCAS/CSE1L is responsible for genome integrity by regulating the intracellular distribution of RAD51.

  2. Azoles activate Atf1-mediated transcription through MAP kinase pathway for antifungal effects in fission yeast

    Lingling Hu, Yue Fang, Tsutomu Hayafuji, Yan Ma and Tomoyuki Furuyashiki

    Article first published online: 23 JUN 2015 | DOI: 10.1111/gtc.12263

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    Azoles activate stress-activated MAP kinase pathway, thereby facilitating Atf1-mediated transcription for antifungal effects.

  3. Loss of ADAR1 in human iPS cells promotes caspase3-mediated apoptotic cell death

    Shota Katayama, Kaori Shimoda and Yuji Takenaga

    Article first published online: 18 JUN 2015 | DOI: 10.1111/gtc.12261

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    Loss of ADAR1 induces caspase3-mediated apoptotic cell death. However, it is dispensable for maintenance of pluripotency.

  4. FBXO21 mediates the ubiquitylation and proteasomal degradation of EID1

    Koki Watanabe, Kanae Yumimoto and Keiichi I. Nakayama

    Article first published online: 18 JUN 2015 | DOI: 10.1111/gtc.12260

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    We applied the CRISPR/Cas9 system to disrupt the endogenous FBXO21 gene in HEK293T cells and evaluated its effect on EID1 stability. Ablation of FBXO21 resulted in a marked increase in the abundance of EID1.

  5. You have full text access to this OnlineOpen article
    Protein monoubiquitylation: targets and diverse functions (pages 543–562)

    Tadashi Nakagawa and Keiko Nakayama

    Article first published online: 18 JUN 2015 | DOI: 10.1111/gtc.12250

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    Monoubiquitylation occurs more frequently than polyubiquitylation. Studies are beginning to provide insight into its biologically important functions.