Comprehensive behavioral study and proteomic analyses of CRMP2-deficient mice
Haruko Nakamura, Naoya Yamashita, Ayuko Kimura, Yayoi Kimura, Hisashi Hirano, Hiroko Makihara, Yuko Kawamoto, Aoi Jitsuki-Takahashi, Kumiko Yonezaki, Kenkichi Takase, Tomoyuki Miyazaki, Fumio Nakamura, Fumiaki Tanaka and Yoshio Goshima
Version of Record online: 1 SEP 2016 | DOI: 10.1111/gtc.12403
We for the first time generated crmp2−/− gene deficient mice. We found that Crmp2−/− mice showed some behavioral abnormalities in activity level, duration of social interaction time and contextual learning. Crmp2−/− mice showed increased mathamphetamine-induced ambulatory activity and serotonin release from the prefrontal cortex. *P < 0.05, **P < 0.01, compared to WT.