CRMP1 and CRMP2 have synergistic but distinct roles in dendritic development
Hiroko Makihara, Shiori Nakai, Wataru Ohkubo, Naoya Yamashita, Fumio Nakamura, Hiroshi Kiyonari, Go Shioi, Aoi Jitsuki-Takahashi, Haruko Nakamura, Fumiaki Tanaka, Tomoko Akase, Pappachan Kolattukudy and Yoshio Goshima
Version of Record online: 2 AUG 2016 | DOI: 10.1111/gtc.12399
In vitro finding suggests that both CRMP1 and CRMP2 are downstream molecules of Sema3A signaling. Dendritic spine density and branching were reduced in double-heterozygous sema3A+/−;crmp2+/− and sema3A+/−;crmp1+/− mice, but the phenotypic defects had no genetic interaction between crmp1 and crmp2. These findings suggest that both CRMP1 and CRMP2 mediate Sema3A signaling to regulate dendritic spine maturation and patterning, but through overlapping and distinct signaling pathways.