Genes to Cells

Cover image for Vol. 20 Issue 3

Early View (Online Version of Record published before inclusion in an issue)

Edited By: Mitsuhiro Yanagida

Impact Factor: 2.855

ISI Journal Citation Reports © Ranking: 2013: 70/165 (Genetics & Heredity); 108/185 (Cell Biology)

Online ISSN: 1365-2443

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  1. 1 - 16
  1. Original Articles

    1. Dendritic cell SIRPα regulates homeostasis of dendritic cells in lymphoid organs

      Ken Washio, Takenori Kotani, Yasuyuki Saito, Datu Respatika, Yoji Murata, Yoriaki Kaneko, Hideki Okazawa, Hiroshi Ohnishi, Atsushi Fukunaga, Chikako Nishigori and Takashi Matozaki

      Article first published online: 27 MAR 2015 | DOI: 10.1111/gtc.12238

    2. White spotting phenotype induced by targeted REST disruption during neural crest specification to a melanocyte cell lineage

      Hitomi Aoki, Akira Hara and Takahiro Kunisada

      Article first published online: 27 MAR 2015 | DOI: 10.1111/gtc.12235

      Thumbnail image of graphical abstract

      The transcriptional repressor RE1-silencing transcription factor (REST), also known as neuron-restrictive silencer factor (NRSF), acts as a negative regulator of neuron-specific genes. While Rest null mice die by E11.5 days with hypoplastic morphological changes, neural crest cell-specific Rest conditional knockout (CKO) mice showed the neonatal death due to swelling of the digestive tract, and the downregulation of acetylcholinesterase activity in the NCC-derived myenteric plexus in the stomach. Here, we generated a viable heterozygote of Rest CKO mice and identified their white spotting phenotype and corresponding localized reduction in skin melanoblasts, suggesting the involvement of Rest in the early melanocyte specification stage.

    3. Notch signaling regulates venous arterialization during zebrafish fin regeneration

      Yoshiko Kametani, Neil C. Chi, Didier Y.R. Stainier and Shinji Takada

      Article first published online: 25 MAR 2015 | DOI: 10.1111/gtc.12234

      Thumbnail image of graphical abstract

      During regeneration of the zebrafish caudal fin, vein-derived cells contributed to the reconstructed arteries. Furthermore, the initiation of this arterialization was dependent on Notch signaling.

    4. Alcohol dehydrogenase 3 contributes to the protection of liver from nonalcoholic steatohepatitis

      Maki Goto, Hiroshi Kitamura, Md. Morshedul Alam, Nao Ota, Takeshi Haseba, Toshio Akimoto, Akio Shimizu, Teruko Takano-Yamamoto, Masayuki Yamamoto and Hozumi Motohashi

      Article first published online: 16 MAR 2015 | DOI: 10.1111/gtc.12237

      Thumbnail image of graphical abstract

      ADH3 is a highly conserved bifunctional enzyme involved in formaldehyde detoxification and termination of nitric oxide signaling. We found that ADH3 protects liver from steatosis independently of NRF2 and prevents the progression of the steatosis into steatohepatitis in cooperation with NRF2.

    5. You have full text access to this OnlineOpen article
      Mef2d is essential for the maturation and integrity of retinal photoreceptor and bipolar cells

      Yoshihiro Omori, Tamiki Kitamura, Satoyo Yoshida, Ryusuke Kuwahara, Taro Chaya, Shoichi Irie and Takahisa Furukawa

      Article first published online: 11 MAR 2015 | DOI: 10.1111/gtc.12233

    6. You have full text access to this OnlineOpen article
      Dynamic transition of transcription and chromatin landscape during fission yeast adaptation to glucose starvation

      Arisa Oda, Naomichi Takemata, Yoshito Hirata, Tomoichiro Miyoshi, Yutaka Suzuki, Sumio Sugano and Kunihiro Ohta

      Article first published online: 2 MAR 2015 | DOI: 10.1111/gtc.12229

    7. rs2294008T, a risk allele for gastric and gallbladder cancers, suppresses the PSCA promoter by recruiting the transcription factor YY1

      Norihisa Saeki, Hiroe Ono, Kazuyoshi Yanagihara, Kazuhiko Aoyagi, Hiroki Sasaki, Hiromi Sakamoto and Teruhiko Yoshida

      Article first published online: 27 FEB 2015 | DOI: 10.1111/gtc.12228

    8. cnrip1 is a regulator of eye and neural development in Xenopus laevis

      Xiaona Zheng, Toshiyasu Suzuki, Chika Takahashi, Eisuke Nishida and Morioh Kusakabe

      Article first published online: 5 FEB 2015 | DOI: 10.1111/gtc.12225

    9. Chemical genomics approach to identify genes associated with sensitivity to rapamycin in the fission yeast Schizosaccharomyces pombe

      Akira Doi, Ayumi Fujimoto, Shun Sato, Takaya Uno, Yuki Kanda, Keita Asami, Yuriko Tanaka, Ayako Kita, Ryosuke Satoh and Reiko Sugiura

      Article first published online: 5 FEB 2015 | DOI: 10.1111/gtc.12223

    10. Geranylgeranyltransferase Cwg2-Rho4/Rho5 module is implicated in the Pmk1 MAP kinase-mediated cell wall integrity pathway in fission yeast

      Akira Doi, Ayako Kita, Yuki Kanda, Takaya Uno, Keita Asami, Ryosuke Satoh, Kentaro Nakano and Reiko Sugiura

      Article first published online: 5 FEB 2015 | DOI: 10.1111/gtc.12222

    11. You have full text access to this OnlineOpen article
      Exportin-5 mediates nuclear export of SRP RNA in vertebrates

      Toshihiko Takeiwa, Ichiro Taniguchi and Mutsuhito Ohno

      Article first published online: 4 FEB 2015 | DOI: 10.1111/gtc.12218

  2. Brief Reports

    1. Identification of a novel role for Drosophila MESR4 in lipid metabolism

      Kayoko Tsuda-Sakurai, Ki-Hyeon Seong, Junjiro Horiuchi, Toshiro Aigaki and Manabu Tsuda

      Article first published online: 30 JAN 2015 | DOI: 10.1111/gtc.12221

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  1. 1 - 16

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