Genes to Cells

Cover image for Vol. 22 Issue 2

Early View (Online Version of Record published before inclusion in an issue)

Edited By: Mitsuhiro Yanagida

Impact Factor: 2.481

ISI Journal Citation Reports © Ranking: 2015: 85/166 (Genetics & Heredity); 123/187 (Cell Biology)

Online ISSN: 1365-2443

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  1. 1 - 6
  1. Original Articles

    1. You have full text access to this OnlineOpen article
      Xeroderma pigmentosum group C protein interacts with histones: regulation by acetylated states of histone H3

      Erina Kakumu, Seiya Nakanishi, Hiromi M. Shiratori, Akari Kato, Wataru Kobayashi, Shinichi Machida, Takeshi Yasuda, Naoko Adachi, Naoaki Saito, Tsuyoshi Ikura, Hitoshi Kurumizaka, Hiroshi Kimura, Masayuki Yokoi, Wataru Sakai and Kaoru Sugasawa

      Version of Record online: 24 FEB 2017 | DOI: 10.1111/gtc.12479

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      XPC, the DNA damage recognition factor involved in mammalian nucleotide excision repair, has at least two interfaces for interactions with histone H3 and/or H1. The N-terminal tail of histone H3 plays a crucial role, and acetylation of histone H3 negatively regulates the interaction with XPC. Subnuclear localization and functions of XPC may be regulated by such interactions with non-acetylated chromatin regions.

    2. Essential roles of Tbx3 in embryonic skin development during epidermal stratification

      Ryo Ichijo, Yui Iizuka, Hirokazu Kubo and Fumiko Toyoshima

      Version of Record online: 16 FEB 2017 | DOI: 10.1111/gtc.12476

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      Tbx3 is required for the epidermal development and skin barrier acquisition.

    3. Codon degeneracy and amino acid abundance influence the measures of codon usage bias: improved Nc (c) and ENCprime (c) measures

      Siddhartha Sankar Satapathy, Ajit Kumar Sahoo, Suvendra Kumar Ray and Tapash Chandra Ghosh

      Version of Record online: 10 FEB 2017 | DOI: 10.1111/gtc.12474

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      Effective number of codons (inline image) and it's variant inline image (Effective number of codons prime) are the two widely used methods for measuring codon usage bias (CUB) in coding sequences. The mathematical formula used in calculating inline image and inline image values are giving inappropriate measures of CUB in case of low abundance of amino acids and the magnitude of error varies according to codon degeneracy. In this study modified formula for inline image and inline image have been developed to measure the CUB more accurately whose online implementations are available in the web portal at http://agnigarh.tezu.ernet.in/~ssankar/cub.php.

    4. Ric-8A, an activator protein of Gαi, controls mammalian epithelial cell polarity for tight junction assembly and cystogenesis

      Kanako Chishiki, Sachiko Kamakura, Junya Hayase and Hideki Sumimoto

      Version of Record online: 10 FEB 2017 | DOI: 10.1111/gtc.12477

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      Ric-8A, a Gαi-activating protein, plays a crucial role in orientation of the mitotic spindle orientation and correct cystogenesis of mammalian epithelial cells. Ric-8A also regulates the formation of tight junctions in epithelial cells. Thus, Ric-8A regulates mammalian epithelial cell polarity for tight junction assembly and cyst morphogenesis, probably with Gαi and its binding proteins LGN and AGS3.

    5. Mediator cyclin-dependent kinases upregulate transcription of inflammatory genes in cooperation with NF-κB and C/EBPβ on stimulation of Toll-like receptor 9

      Seiji Yamamoto, Tomoko Hagihara, Yoshiyuki Horiuchi, Akira Okui, Shotaro Wani, Tokuyuki Yoshida, Takao Inoue, Aki Tanaka, Takashi Ito, Yutaka Hirose and Yoshiaki Ohkuma

      Version of Record online: 2 FEB 2017 | DOI: 10.1111/gtc.12475

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      Here the present study focused on Toll-like receptors (TLRs), which exert innate immune responses through recognition of pathogen-associated molecular patterns and examined the functional roles of CDK8/19. As a result, CDK8/19 regulated transcription of inflammatory genes on stimulation of TLR9 in myeloma-derived RPMI8226 cells, which led to expression of inflammation-associated genes.

    6. Knock-in strategy at 3′-end of Crx gene by CRISPR/Cas9 system shows the gene expression profiles during human photoreceptor differentiation

      Kohei Homma, Sumiko Usui and Makoto Kaneda

      Version of Record online: 26 JAN 2017 | DOI: 10.1111/gtc.12472

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      In this work, we have developed the human induced pluripotent stem cell (hiPSC) knock-in lines those report specific gene expression without cloning of the promoter gene or affecting the gene function. Using CRISPR/Cas9 system, we successfully inserted the 2A peptide gene and fluorescent protein gene at 3′end of target gene, Crx. We believe this knock-in reporter system is valuable not only for the labeling specific cell lineages but also for the monitoring expression of any marker genes whose promoters are not identified.

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