Genes to Cells

Cover image for Vol. 20 Issue 4

Edited By: Mitsuhiro Yanagida

Impact Factor: 2.855

ISI Journal Citation Reports © Ranking: 2013: 70/165 (Genetics & Heredity); 108/185 (Cell Biology)

Online ISSN: 1365-2443

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Genes to Cells will be available online only from 2015. For more information and to receive electronic Table of Content alerts each time a new issue is published online, please see here.

Recently Published Articles

  1. Regulation by gut commensal bacteria of carcinoembryonic antigen-related cell adhesion molecule expression in the intestinal epithelium

    Yasuaki Kitamura, Yoji Murata, Jung-ha Park, Takenori Kotani, Shinya Imada, Yasuyuki Saito, Hideki Okazawa, Takeshi Azuma and Takashi Matozaki

    Article first published online: 23 APR 2015 | DOI: 10.1111/gtc.12247

  2. Trp250-hK2 is defective in intracellular trafficking and activates the unfolded protein response

    Eun Ju Choi, Sei Mee Yoon, Suman Lee and Jinu Lee

    Article first published online: 6 APR 2015 | DOI: 10.1111/gtc.12242

    Thumbnail image of graphical abstract

    The T allele on rs198977, a SNP in KLK2 codes for W-hK2 and are associated with lower level of hK2 and higher risk of prostate cancer. W-hK2 is defective in cellular trafficking and activates unfolded protein response, suggesting a mechanism underlying this functional SNP.

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    RNA pol II transcript abundance controls condensin accumulation at mitotically up-regulated and heat-shock-inducible genes in fission yeast

    Norihiko Nakazawa, Kenichi Sajiki, Xingya Xu, Alejandro Villar-Briones, Orie Arakawa and Mitsuhiro Yanagida

    Article first published online: 6 APR 2015 | DOI: 10.1111/gtc.12239

    Thumbnail image of graphical abstract

    Conserved protein complex ‘condensin’ is a central player for chromosome dynamics. We demonstrated that RNA polymerase II (pol II)-mediated transcripts cause condensin accumulation at fission yeast (Schizosaccharomyces pombe) chromosomes. Abundant pol II transcription may require active condensin prior to proper chromosome segregation.

  4. Dendritic cell SIRPα regulates homeostasis of dendritic cells in lymphoid organs

    Ken Washio, Takenori Kotani, Yasuyuki Saito, Datu Respatika, Yoji Murata, Yoriaki Kaneko, Hideki Okazawa, Hiroshi Ohnishi, Atsushi Fukunaga, Chikako Nishigori and Takashi Matozaki

    Article first published online: 27 MAR 2015 | DOI: 10.1111/gtc.12238

  5. White spotting phenotype induced by targeted REST disruption during neural crest specification to a melanocyte cell lineage

    Hitomi Aoki, Akira Hara and Takahiro Kunisada

    Article first published online: 27 MAR 2015 | DOI: 10.1111/gtc.12235

    Thumbnail image of graphical abstract

    The transcriptional repressor RE1-silencing transcription factor (REST), also known as neuron-restrictive silencer factor (NRSF), acts as a negative regulator of neuron-specific genes. While Rest null mice die by E11.5 days with hypoplastic morphological changes, neural crest cell-specific Rest conditional knockout (CKO) mice showed the neonatal death due to swelling of the digestive tract, and the downregulation of acetylcholinesterase activity in the NCC-derived myenteric plexus in the stomach. Here, we generated a viable heterozygote of Rest CKO mice and identified their white spotting phenotype and corresponding localized reduction in skin melanoblasts, suggesting the involvement of Rest in the early melanocyte specification stage.