Genes to Cells

Cover image for Vol. 22 Issue 10

Edited By: Mitsuhiro Yanagida

Impact Factor: 1.993

ISI Journal Citation Reports © Ranking: 2016: 106/166 (Genetics & Heredity); 145/189 (Cell Biology)

Online ISSN: 1365-2443

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Recently Published Articles

  1. Induction of erythropoietin gene expression in epithelial cells by chemicals identified in GATA inhibitor screenings

    Hiroshi Kaneko, Takehide Katoh, Ikuo Hirano, Atsushi Hasegawa, Tadayuki Tsujita, Masayuki Yamamoto and Ritsuko Shimizu

    Version of Record online: 18 OCT 2017 | DOI: 10.1111/gtc.12537

    Thumbnail image of graphical abstract

    Mitoxantrone and its analogues markedly induce EPO/Epo gene expression in epithelium-derived cell lines and mice regardless of oxygen levels. EPO production in uninjured adult epithelial cells may be a therapeutic approach for renal anemia in patients with CKD.

  2. You have full text access to this OnlineOpen article
    Hikeshi modulates the proteotoxic stress response in human cells: Implication for the importance of the nuclear function of HSP70s

    Khondoker Md Zulfiker Rahman, Hiroshi Mamada, Masatoshi Takagi, Shingo Kose and Naoko Imamoto

    Version of Record online: 5 OCT 2017 | DOI: 10.1111/gtc.12536

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    We found that Hikeshi is required for the survival of HeLa cells in response to proteotoxic stress, but depletion of Hikeshi increases the survival of hTERT-RPE1 cells. Depletion of Hikeshi renders HeLa cells proteotoxic stress-sensitive through the abrogation of the nuclear function of HSP70s required for HSF1 regulation. In addition, we found Hikeshi-depleted hTERT-RPE1 upregulates p21, which could be one cause of its proteotoxic stress resistance.

  3. Elucidation of GlcNAc-binding properties of type III intermediate filament proteins, using GlcNAc-bearing polymers (pages 900–917)

    Hirohiko Ise, Sadanori Yamasaki, Kazuaki Sueyoshi and Yoshiko Miura

    Version of Record online: 12 SEP 2017 | DOI: 10.1111/gtc.12535

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    Confocal laser scanning images show the interactions of cell surface-expressed vimentin with GlcNAc-bearing polymers and the localization of caveolin-1 on HeLa cells.

  4. Effect of different light–dark schedules on estrous cycle in mice, and implications for mitigating the adverse impact of night work (pages 876–884)

    Kiichi Yoshinaka, Ai Yamaguchi, Ritsuko Matsumura, Koichi Node, Isao Tokuda and Makoto Akashi

    Version of Record online: 8 SEP 2017 | DOI: 10.1111/gtc.12522

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    Here, we report that repetitive reversal of light-dark (LD) cycles triggers irregular estrous cycles in mice. The findings revealed that the estrous cycle remained irregular for more than four weeks after the mice were returned to regular LD cycles. Importantly, the magnitude of the negative impact of reversed LD cycles on the estrous cycle was dependent on the difference in the frequency of LD reversal.

  5. Extracellular vesicle-mediated MFG-E8 localization in the extracellular matrix is required for its integrin-dependent function in mouse mammary epithelial cells (pages 885–899)

    Takuya Ooishi, Daita Nadano, Tsukasa Matsuda and Kenzi Oshima

    Version of Record online: 8 SEP 2017 | DOI: 10.1111/gtc.12521

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    Mouse MFG-E8 was transiently localized to the mammary basal lamina during involution. MFG-E8 was connected extracellular matrix with extracellular vesicles, and this basal localization was required for its integrin-dependent function in adherent cells.

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