Genes to Cells

Cover image for Vol. 20 Issue 11

Edited By: Mitsuhiro Yanagida

Impact Factor: 2.805

ISI Journal Citation Reports © Ranking: 2014: 70/167 (Genetics & Heredity); 111/184 (Cell Biology)

Online ISSN: 1365-2443

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Recently Published Articles

  1. MiR-29-mediated elastin down-regulation contributes to inorganic phosphorus-induced osteoblastic differentiation in vascular smooth muscle cells

    Ryo Sudo, Fumiaki Sato, Takuya Azechi and Hiroshi Wachi

    Article first published online: 27 NOV 2015 | DOI: 10.1111/gtc.12311

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    This basic study investigated the mechanism of elastin down-regulation in the progression of calcification, focusing on clarifying the effect of microRNA; miR-29 which is the regulator of elastin expression. We demonstrated that elastin down-regulation, which are regulated by miR-29, played a pivotal role in the progression of vascular smooth muscle cells calcification via osteoblastic differentiation.

  2. Distal regulatory element of the STAT1 gene potentially mediates positive feedback control of STAT1 expression

    Katsutoshi Yuasa and Takao Hijikata

    Article first published online: 23 NOV 2015 | DOI: 10.1111/gtc.12316

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    A novel distal regulatory element 5.5URR could mediate positive feedback regulation of the STAT1 gene expression. Through this autoregulation, the 5.5URR could also contribute to the amplification and/or prolongation of intracellular IFN signals.

  3. Effects of 6-meals-a-day feeding and 6-meals-a-day feeding combined with adrenalectomy on daily gene expression rhythms in rat epididymal white adipose tissue

    Yan Su, Ewout Foppen, Zhi Zhang, Eric Fliers and Andries Kalsbeek

    Article first published online: 15 NOV 2015 | DOI: 10.1111/gtc.12315

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    We investigated the importance of adrenal hormones and a daily feeding rhythm as rhythmic outputs of the biological clock to synchronize day/night rhythms in (clock) gene expression in white adipose tissue (WAT). We found that at least one of these two outputs should be present in order for WAT clock gene rhythms to be maintained.

  4. Relative contribution of four nucleases, CtIP, Dna2, Exo1 and Mre11, to the initial step of DNA double-strand break repair by homologous recombination in both the chicken DT40 and human TK6 cell lines

    Nguyen Ngoc Hoa, Remi Akagawa, Tomomi Yamasaki, Kouji Hirota, Kentaro Sasa, Toyoaki Natsume, Junya Kobayashi, Tetsushi Sakuma, Takashi Yamamoto, Kenshi Komatsu, Masato T. Kanemaki, Yves Pommier, Shunichi Takeda and Hiroyuki Sasanuma

    Article first published online: 2 NOV 2015 | DOI: 10.1111/gtc.12310

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    Using genome-editing technology, we here engineered the nuclease mutants of human TK6 cell line, which are involved in DNA double-strand break repair. Among the mutants, we found that CtIP and Dna2 predominantly function in the process of DSB resection to ensure efficient DSB repair by HR in human cells.

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    Casein kinase 1γ acts as a molecular switch for cell polarization through phosphorylation of the polarity factor Tea1 in fission yeast

    Takayuki Koyano, Karin Barnouin, Ambrosius P. Snijders, Kazunori Kume, Dai Hirata and Takashi Toda

    Article first published online: 2 NOV 2015 | DOI: 10.1111/gtc.12309

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    When Tea1 is entrapped by Cki3 to the cell membrane, Tea1 is hyperphosphorylated, thereby becoming inactive for the potentiation of growth from the cell tip. Under this condition, interaction between Tea1 and Tea4 is compromised. Phosphomimetic Tea1 recapitulates the nongrowth phenotype.