International Journal of Experimental Pathology

Cover image for Vol. 97 Issue 6

Edited By: David R Katz

Impact Factor: 2.125

ISI Journal Citation Reports © Ranking: 2015: 31/79 (Pathology)

Online ISSN: 1365-2613

Author Guidelines

Author Guidelines

The International Journal of Experimental Pathology (formerly the British Journal of Experimental Pathology) has been published continuously since 1920. It has been published in an online only format since January 2014.

1. Aims and Scope

Experimental Pathology encompasses the use of multidisciplinary scientific techniques to investigate the pathogenesis and progression of pathologic processes.

The International Journal of Experimental Pathology - IJEP – aims to publish high quality papers which afford new and imaginative insights into Experimental Pathology, thus helping to elucidate further the mechanisms which underlie disease. Founded in 1920 by the late Paul Fildes (as the British Journal of Experimental Pathology), IJEP has contributed several major advances to the biomedical science literature, ranging from the original penicillin observation:
to the first report of the animal model of Ebola virus:

In order to continue to achieve this aim IJEP considers for publication papers across a broad spectrum of investigative approaches. This can be in the form of in vitro studies, animal models, and clinical research. The key objectives are (i) to report on work that addresses the common theme of mechanism at a cellular and molecular level; and (ii) to interpret this work both as a scholarly scientific report per se, and in a translational context.

Thus, IJEP provides a forum for publication about pathology and aetiology of both human and veterinary diseases, both acute and chronic inflammatory processes (infective and non-infective), toxicological and traumatic injury, degenerative and iatrogenic disease, fibrosis and cancer.

There are three forms of IJEP publication: (i) original research papers reporting directly on experimental investigations; (ii) review papers (both contributed and commissioned) and (iii) letters to the Editor about topics that have been covered in the Journal, to which authors are invited to respond.

With regard to original papers, based upon the aims and objectives outlined above, IJEP appreciates that a wide range of methods may need to be incorporated into the text. The emphasis is on hypothesis driven investigations, rather than on case reports and descriptive studies.

There is a long IJEP tradition of publishing review papers . Sometimes these focus on individual themes. For example, the most “long-lived” IJEP review paper explored animal models of steatohepatitis: and another recent review looked at the molecular models that are important in the study of muscular dystrophy. Others are published as a series: themes have included angiogenesis, renal disease experimental models, and tendon biology and pathology.

IJEP has traditionally taken an interest in the connective tissue microenvironment – its structure, and its relationship to the dynamic processes, often chronic, that occur within it, as well as the pathology of the tissues themselves. The relationship between the tissue site, cell and matrix, inflammation and scarring, has been explored at many different sites, particularly the lung and the synovial joint. Furthermore, IJEP sponsors and publishes the Fell Muir Award lecture series in this field, organised by the British Society for Matrix Biology.

IJEP pays particular attention that research reported conforms to currently accepted ethical standards; that conflicts of interest are declared; and that funding sources and other forms of assistance are acknowledged. Further details about how these aspects should be addressed are discussed below.

2. English Language Requirements

IJEP is unable to undertake corrections of language, which is the responsibility of the author. Papers will be unsubmitted from the Journal immediately if the paper does not meet these criteria. Papers must be written in clear, concise English. Spelling should follow The Concise Oxford Dictionary of Current English. Avoid jargon and neologisms. Where English is not the first language of the authors, the paper should be checked by a native English speaker.

As a service to authors, Wiley can recommend an independent English language editing service to authors to ensure manuscripts are ready for submission. For more details of this service visit:

3. Publication Ethics and Policy

3.1 Ethical Policy

IJEP pays particular attention that research reported conforms to ethical standards.

Information on various issues relating to Publication Ethics are dealt with in the relevant sections below but are outlined in full in a separate document Ethical Policies of the International Journal of Experimental Pathology.

These ethical policies are based on the Best Practice Guidelines on Publication Ethics: a Publisher's Perspective, 2nd edn from Wiley, and the COPE Code of Conduct and Best Practice Guidelines for Journal Editors .

IJEP is a member of the Committee on Publication Ethics (COPE). COPE principles are that submission is considered on condition that papers are previously unpublished, and are not offered simultaneously elsewhere; that all authors (defined below) have read and approved the content; that all authors have disclosed financial and other conflicts of interests; and that the work complies with the ethical policies of the Journal having been conducted under internationally accepted ethical standards after relevant ethical review by a designated ethical authority.

3.2 Animal Studies

Manuscripts describing studies involving animals should comply with local/national guidelines governing the use of experimental animals and must contain a statement indicating that the procedures have been approved by the appropriate regulatory body.

3.3 Human Studies

Manuscripts concerned with human studies must contain statements indicating that informed, written consent has been obtained, that studies have been performed according to the Declaration of Helsinki, and that the procedures have been approved by a local ethics committee. If individuals might be identified from a publication (e.g. from images) authors must obtain explicit consent from the individuals.

3.4 Conflicts of Interest(s) Statements

Conflicts of interest(s) – including a null declaration – are a required section within papers that are published in the Journal.

All authors must include full details of any conflicts of interest in a Conflicts of Interest section. Authors are required to disclose financial interests (e.g. employment, significant share ownership, patent rights, consultancy, research funding, etc.) in any company or institution that might benefit from their publication. All authors must provide details of any other potential competing interests of a personal nature that readers or editors might consider relevant to their publication.

In addition to this section in the manuscript itself, upon acceptance for publication, all authors must supply full details of any such conflicts of interest by e-mailing this to the Journal's editorial assistant Biljana Nikolic .

Note that reviewers are also required to provide information about any Conflicts of Interest.

Fuller details about the nature of these statements are in the Ethical Policies of the International Journal of Experimental Pathology.

3.5 Funding Statement

All papers must include a Funding Statement section where disclosure of funding sources are included in a separate section within the paper.

All sources of funding must be disclosed. This includes governmental, industrial, charitable, philanthropic and/or personal sources. The key issue is transparency about how the studies described in the manuscript were resourced. Where appropriate funding should be attributed to the relevant author(s).


This study was funded by a National Health and Medical Research Council of Australia
Project Grant (DN-P, FM) and a National Health and Medical Research Council of Australia
Senior Research Fellowship (DN-P).

This paper was supported by a grant from the Brazilian agency CNPq (Brazilian National Research and Development Council, Procs. Nr. 301596/2011-5; 475148/2012-6) and FAPEG (Goiás Research Foundation, Procs Nr. 05/2012).

This work was supported by the Uehara Memorial Foundation, Tokyo, Japan and by Grants-in-Aid for Scientific Research (23390480 & 23792512) from the Ministry of Education, Culture, Sports, Science and Technology, Tokyo, Japan.

This work was supported by grants from National Natural Science Foundation of China (No.81272252), Natural Science Foundation of Jiangsu Province (No. BK2011656).

3.6 Acknowledgements

All papers must include an Acknowledgement section where all acknowledgments are grouped together. The Acknowledgement section may include comments recognising input into the manuscript which is not part of authorship, but is nonetheless helpful. For example, animal welfare, language, scientific guidance, statistical and technical assistance can be recorded in this section. The authors should acknowledge those who have made substantial contributions to the study or preparation of the manuscript but whose contributions do not fulfil the requirements for authorship – see below.

3.7 Authorship

All authors must fulfil the following three criteria:

· Substantial contributions to research design, or the acquisition, analysis or interpretation of data,
· Drafting the manuscript or revising it critically, and
· Approval of the submitted and final versions.

4. Manuscript Submission and Review Process

4.1 The Review Process

All submitted manuscripts are subject to review by experienced reviewers, and the reviewers and Editorial Board views are considered by the Editor. Authors may suggest the names of suitable reviewers in a covering letter, or via the website, if they so wish. The Editor selects and accepts manuscripts suitable for publication - the Editor’s decision is final. Manuscripts accepted for publication are copyedited and typeset. The proofs are sent to the Corresponding Author for a final check, but extensive changes to the proofs may be charged to the contributors.

4.2 Conditions of Acceptance

Manuscripts are accepted on the understanding that no substantial part has been, or will be, published elsewhere. All submitted manuscripts will be scrutinised for possible overlap and duplication with already published work. Manuscripts may be subject to editorial revision without notice and remain the copyright of the Journal. If a manuscript that has been returned to authors for revision is not received back in the editorial office after 90 days, it will be treated as a new submission. The Editor reserves the right to make the final decision whether or not a manuscript is accepted.

The author who submits a manuscript for publication is responsible for ensuring that all other authors agree to its submission. All manuscripts must be accompanied by a covering letter which is approved signed by the Corresponding Author on behalf of all authors. Persons named in the acknowledgements, and those responsible for any personal communications, must have agreed formally to their names so appearing.

4.3 Online Submission

Manuscripts should be submitted online at

In order to submit authors will require a user ID and password, which can be obtained on first use of the submission website. Full instructions are provided when accessing the website. All file types are supported, but to help the Editor and reviewers view the submission the following types are recommended:

Text: Microsoft Word (.doc or .docx) or generic rich text format (RTF).

For details on formats for Tables and Figures submissions, refer to Tables and Figures section: 7. Manuscript Format.

It is strongly recommended that, where possible, authors combine all parts of their submission into a single document. Alternatively authors may submit the text of the manuscript (including front page, summary, body of text, references and legends to tables and figures) as one document, with tables and figures as a separate file.

Full help and support for online submissions are provided by e-mail (, or telephone (+1 434 964 4100/+1 888 503 1050)

5. OnlineOpen

OnlineOpen is available to authors of primary research papers who wish to make their papers available to non-subscribers on publication, or whose funding agency requires grantees to archive the final version of their paper. With OnlineOpen, the author, the author's funding agency, or the author's institution pays a fee to ensure that the paper is made available to non-subscribers upon publication via Wiley Online Library, as well as deposited in the funding agency's preferred archive.

To preview the terms and conditions of these open access agreements please visit the Copyright FAQs hosted on Wiley Author Services and visit . All OnlineOpen papers are treated in the same way as any other paper. They go through the Journal's standard peer-review process and will be accepted or rejected based on their own merit.

6. Copyright

When manuscripts are accepted, the authors identified as the formal Corresponding Author for the manuscript will receive an email prompting them to login into Author Services; where via the Wiley Author Licensing Service (WALS) they will be able to complete the license agreement on behalf of all authors on the manuscript.

For authors signing the copyright transfer agreement

If the OnlineOpen option is not selected, the Corresponding Author will be presented with the copyright transfer agreement (CTA) to sign. The terms and conditions of the CTA can be previewed in the samples associated with the Copyright FAQs below:

CTA Terms and Conditions

For authors choosing OnlineOpen

If the OnlineOpen option is selected, the Corresponding Author will have a choice of the following Creative Commons License Open Access Agreements (OAA):

· Creative Commons Attribution License OAA
· Creative Commons Attribution Non-Commercial License OAA
· Creative Commons Attribution Non-Commercial -NoDerivs License OAA

To preview the terms and conditions of these open access agreements please visit the Copyright FAQs hosted on Wiley Author Services and visit . See the Online Open section below for more information.

If the OnlineOpen option is selected, and the research is funded by The Wellcome Trust and members of the Research Councils UK (RCUK), the Corresponding Author will be given the opportunity to publish the paper under a CC-BY license to comply with The Wellcome Trust and Research Councils UK requirements. For more information on this policy and the Journal’s compliant self-archiving policy please visit:

7. Manuscript Format

Manuscripts must be saved for submission in double spaced format.

The date of submission used will be the date of submission of the electronic text version. Authors are advised to keep a copy of all manuscripts, as no responsibility can be accepted for loss.

The text should follow the following format:

Front page:

A single 'front page' must give: (1) the title of the manuscript; (2) a short running title (not exceeding 40 characters); (3) the name(s) of the author(s) including forename and surname; (4) the department(s) in which the work was done; and (5) the name, full postal address, fax number and e-mail address of the author to whom the proofs and requests for offprints should be sent, to be headed 'Correspondence'. The Corresponding Author should take responsibility for communicating with all other authors and getting their approval for the final version to be published. During online submission Corresponding Authors can nominate an individual, who may or may not be an author, to assist them with administration of the publication process.

The Corresponding Author should confirm that all listed authors meet ICMJE authorship criteria and that nobody who qualifies for authorship has been excluded. See Section 3.5 Authorship.

Second page:

The second page should contain a summary paragraph which should give a factual account of the context in which the study has been performed, the objective(s), methods and results, and a brief conclusion, in not more than 250 words. For reviewing and indexing purposes, up to six 'keywords' related to subjects discussed in the paper should be identified and included at the foot of the summary.

Original Research Papers

Reports of original work should usually be arranged in the conventional order of introduction, methods, results, discussion, acknowledgements and references, with suitable headings for each part. Further sub-divisions, with appropriately less significant headings, can be used. Results may be presented in the text, in tables and figures, but the text should, in general, comment on rather than repeat information in tables.

Review Papers

Review papers will usually be commissioned, but the Journal also accepts submissions that have not been solicited. For unsolicited reviews, authors are advised to consult the Editor in advance. Once the Editor has agreed to consider a review paper, the guidelines for submitting online are the same as for an original research paper.

Letters to the Editor

Correspondence which relates to papers which have recently appeared in the Journal may be published. The Editor reserves the right to invite a response from the original authors for publication alongside. Letters should be as short as possible (but no more than 1000 words of text, two figures or tables or one of each, and up to 10 references). Correspondence to the Journal is accepted on the understanding that the contributing author licences the publisher to publish the letter as part of the Journal or separately from it, in the exercise of any subsidiary rights relating to the Journal and its contents.

Tables and Figures

For online submission, illustrations should be embedded in the Word document or uploaded as separate files. Quality should be sufficient for viewing on-screen and desktop printing.

Where possible, please provide high quality digital artwork files.

Figures: JPEG, GIF, EPS, PNG Microsoft PowerPoint, Microsoft Excel, Microsoft Word are all acceptable.

Digital images: Digital versions of figures should be supplied in TIFF format.

Both tables and figures should be numbered consecutively with Arabic numerals. Each should have a separate descriptive legend. Keys should be given in the legends, not in the figure itself. All illustrations, both drawings and photographs, must be of good quality since delay will result if reviewers need to see improved versions. As a guide, the ideal figure resolution/specification for various types of original figures, at their final size, is as follows:

Line art and diagrams - Minimum 600 dpi
Halftone (both B/W and Colour photographs) - Minimum 300 dpi
Line and tone (line art and halftone combined) - Minimum 600 dpi

It is best to use Illustrator or Photoshop software and to save the material in the format '.eps' or '.tif'. If the author is unable to provide these formats, please save the figures in as many different file formats as possible. For further information on file formats, please see the instructions at p

Colour Illustrations

IJEP is published online only and there is no charge for the inclusion of colour figures.

Supporting Information

Authors may supply additional text or data as ‘Supporting Information Files, but the main manuscript must contain sufficient information to make the work intelligible without these files. Supporting information is a formal part of the published manuscript and should not normally be re-published elsewhere.

Our recommended file types for Supporting Information are: .doc/ .xls/ .ppt/ .txt/ .jpg/ .jpeg/ .gif/ .tif/ .tiff/ .png/ .bmp/ .eps/ .ps/ .html/ .pdf/ .mov/ .mpg/ .wav/ .mp3/ .wma

Please note that Supporting Information is not subedited or proof read, so authors should ensure that files are supplied ready for publication online. File sizes must be as small as possible, so that they can be downloaded quickly and must not exceed 50MB.


Measurements should be expressed in SI units. If the original observations were recorded in other units, this should be stated, together with the appropriate conversion factors.

Standard Abbreviations

Standard abbreviations should be used and should follow those laid down in Units, Symbols and Abbreviations (1994) published by the Royal Society of Medicine. Abbreviations should be used sparingly and only if a lengthy name or expression is repeated frequently throughout the manuscript. Words must appear in full on first appearance in both summary and text, followed by the abbreviation in parentheses. Drugs should be described by their official names but trade names should be indicated in parentheses the first time the drug is quoted in the text.


Authors are required to include details of ethical approval, disclosure of financial and other conflicts of interest and funding sources.


We recommend the use of a tool such as Reference Manager (Harvard) for reference management and formatting. References must be double spaced and should be made only to papers closely related to the author's work. Exhaustive lists should be avoided. In the text, use the name of the author(s) followed by the date of publication; where there are two authors use the form: Nankivell B.J. & Alexander S.I. (2010) where there are more than two authors use the form: Burandt, E., M. Schreiber, et al. (2014).

Arrange the list of authors quoted at the end of the text in alphabetical order set out as follows:

A) Name(s) and initials of author(s), year of publication (in parentheses), title of the article, name of the journal, volume number, first and last page numbers. Abbreviate journal names according to the Index Medicus system.

B) In the case of books the order is: name(s) and initials of author(s), year of publication (in parentheses), chapter title, full book title, edition, names of the editors, place and name of publisher, and page numbers.

C) Personal communications should be cited in the text of your document only and be accompanied by a letter of permission, They may be referred to in the text (author’s name followed by ‘unpublished observation’ or ‘personal communication’ .

D) The Journal encourages citation of online papers before they are published in final form when they become available in PubMed or from journal/publisher websites, e.g. Early View articles from the International Journal of Andrology website. The citation must take the following form:

Author(s), Title, Journal, Year; in press (DOI).

Any paper that is In Press but lacks a DOI will not be considered a valid reference citation and cannot be cited.

Search Engine Optimisation

Many students and researchers looking for information online will use search engines such as Google, Yahoo or similar. By authors optimising their papers for search engines, this will increase the chance of someone finding their published work. This in turn will make their papers more likely to be viewed and/or cited in another work.

Please see the Tips Sheet for optimising the discoverability of papers and promoting them post-publication, and the Wiley Exchanges blog post for advice on choosing keywords for papers.


Materials copied from other sources must be accompanied by a written statement from both author and publisher giving permission to the International Journal of Experimental Pathology for reproduction. Authors are responsible for obtaining permission in writing from at least one author of papers cited while still in press, as well as of unpublished data and of personal communications. It is the author's responsibility to ensure that permissions are obtained.

8. Page Proofs

Proofs will be sent electronically via e-mail as an Acrobat PDF file. The e-mail server must be able to accept attachments up to 4 MB in size. Acrobat Reader will be required in order to read this file. This software can be downloaded (free of charge) from the following Web site:

This will enable the file to be opened, read and corrected on screen. Further instructions will be sent at the same time as the proof. Proofs will be posted if no email address is available. In the Corresponding Author’s absence, please arrange for a colleague to access this email to retrieve the proofs.

9. Early View

The International Journal of Experimental Pathology is covered by Wiley-Blackwell's Early View service. Early View articles are complete full-text articles published online in advance of their publication in a printed issue. Articles are therefore available as soon as they are ready, rather than having to wait for the next scheduled issue. Early View articles are complete and final. They have been fully reviewed, revised and edited for publication, and the authors’ final corrections have been incorporated. Because they are in final form, no changes can be made after online publication. The nature of Early View articles means that they do not yet have volume, issue or page numbers, so Early View articles cannot be cited in the traditional way. They are therefore given a Digital Object Identifier (DOI), which allows the article to be cited and tracked before it is allocated to an issue. After publication in an issue, the DOI remains valid and can continue to be used to cite and access the article.

10. Author Services

Online production tracking is now available through Wiley-Blackwell’s Author Services. Author Services enables authors to track their papers - once it has been accepted - through the production process to publication online. Authors can check the status of their papers online and choose to receive automated emails at key stages of production so they don’t need to contact the production editor to check on progress. Visit for more details on online production tracking and for a wealth of resources including FAQs and tips on paper preparation, submission and more.