Journal of Clinical Pharmacy and Therapeutics

Cover image for Vol. 41 Issue 2

Early View (Online Version of Record published before inclusion in an issue)

Edited By: A. Li Wan Po

Impact Factor: 1.668

ISI Journal Citation Reports © Ranking: 2014: 171/255 (Pharmacology & Pharmacy)

Online ISSN: 1365-2710


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  1. Case Reports

    1. Micafungin and a case of polymorphic ventricular tachycardia

      P. J. Shah, V. Sundareshan, B. Miller and S. J. Bergman

      Article first published online: 28 APR 2016 | DOI: 10.1111/jcpt.12386

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      This patient developed polymorphic ventricular tachycardia suggestive of Torsades de pointes following the initiation of micafungin for esophageal candidiasis while on amiodarone. Based on the timing of this event, the Naranjo probability scale for adverse drug reactions indicates a possible association.

  2. Original Articles

    1. You have full text access to this OnlineOpen article
      Clinical efficacy and safety of topiroxostat in Japanese male hyperuricemic patients with or without gout: an exploratory, phase 2a, multicentre, randomized, double-blind, placebo-controlled study

      T. Hosoya, T. Sasaki, H. Hashimoto, R. Sakamoto and T. Ohashi

      Article first published online: 15 APR 2016 | DOI: 10.1111/jcpt.12392

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      We evaluated the dose–response relationship in respect of the serum urate-lowering efficacy of topiroxostat, a novel selective xanthine oxidoreductase inhibitor for the treatment of hyperuricemia with or without gout in Japan, which was newly developed by Fuji Yakuhin Co., Ltd. The study demonstrated its dose–response relationship in respect of the serum urate reduction and a superior mean per cent change of the serum urate from the baseline at the end of the study period.

    2. Update meta-analysis of the CYP2E1 RsaI/PstI and DraI polymorphisms and risk of antituberculosis drug-induced hepatotoxicity: evidence from 26 studies

      F.-J. Wang, Y. Wang, T. Niu, W.-X. Lu, A. J. Sandford and J.-Q. He

      Article first published online: 9 APR 2016 | DOI: 10.1111/jcpt.12388

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      We performed a large meta-analysis on the association of the CYP2E1 polymorphisms with susceptibility to antituberculosis drug-induced hepatotoxicity (ATDH). The overall ORs of relevant studies demonstrated that the CYP2E1 RsaI/PstI C1/C1 genotype was associated with an elevated risk of ATDH (OR = 1.32, 95% CI 1.03–1.69, P = 0.027).

    3. Residential medication management reviews of antithrombotic therapy in aged care residents with atrial fibrillation: assessment of stroke and bleeding risk

      P. S. Nishtala, R. L. Castelino, G. M. Peterson, P. J. Hannan and M. S. Salahudeen

      Article first published online: 7 APR 2016 | DOI: 10.1111/jcpt.12385

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      The study assessed the risk of stroke for aged care home residents with atrial fibrillation (AF) and examined Residential Medication Management (RMMR) reviews on the utilization of antithrombotic therapy. This study found anticoagulants were underutilized in eligible older people with AF. Guideline-recommended stroke scoring systems, in combination with bleeding risk assessment, may assist RMMR service providers in determining the net clinical benefit of antithrombotic therapy in older adults with AF.

  3. Case Reports

    1. Oral verapamil in the prevention of recurrent cerebral ischaemia due to post-stent vasospasm

      V. Rastogi, G. Asaithambi, A. Patel, K. Park, S. Bidari and V. S. Hedna

      Article first published online: 6 APR 2016 | DOI: 10.1111/jcpt.12387

  4. Original Articles

    1. You have full text access to this OnlineOpen article
      Statin-related aminotransferase elevation according to baseline aminotransferases level in real practice in Korea

      H.-S. Kim, S. H. Lee, H. Kim, S.-H. Lee, J. H. Cho, H. Lee, H. W. Yim, S.-H. Kim, I.-Y. Choi, K.-H. Yoon and J. H. Kim

      Article first published online: 25 MAR 2016 | DOI: 10.1111/jcpt.12377

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      The progression rate to abnormal AST/ALT values (>×3 the UNL) was significantly higher in subjects with borderline (>×1, but ≤ ×3 of UNL) compared to normal AST/ALT values at baseline. It is advisable to regularly monitor AST/ALT levels in patients with AST/ALT increases >×1, but ≤×3 of UNL.

  5. Case Reports

    1. Peripheral arterial occlusive disease during ponatinib therapy after failure of imatinib: a case report

      G. Tournaire, F. Despas, F. Huguet, J. L. Montastruc and E. Bondon-Guitton

      Article first published online: 23 MAR 2016 | DOI: 10.1111/jcpt.12383

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  6. Original Articles

    1. Polypharmacy of medications and fall-related fractures in older people in Japan: a comparison between driving-prohibited and driving-cautioned medications

      N. Iihara, Y. Bando, M. Ohara, T. Yoshida, T. Nishio, T. Okada and Y. Kirino

      Article first published online: 17 MAR 2016 | DOI: 10.1111/jcpt.12381

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      An elevated risk of fall-related fractures was observed with the intake of an increasing number of driving-prohibited medications, with no association between driving-cautioned medications and fall-related fractures. Medication class is a more important risk factor for fall-related fractures rather than polypharmacy alone with no regard for medication class.

    2. Midodrine for the weaning of vasopressor infusions

      L. B. Poveromo, E. L. Michalets and S. E. Sutherland

      Article first published online: 4 MAR 2016 | DOI: 10.1111/jcpt.12375

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      Midodrine has been used at our institution as an adjunctive treatment to provide haemodynamic support to facilitate intravenous (IV) vasopressor weaning in patients who have difficulty discontinuing IV vasopressors. After completing treatment with midodrine, 95·7% of patients remained off IV vasopressors.

    3. Medication adherence may be more important than other behaviours for optimizing glycaemic control among low-income adults

      C. Y. Osborn, L. S. Mayberry and J. M. Kim

      Article first published online: 4 MAR 2016 | DOI: 10.1111/jcpt.12360

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      In a cross-sectional study of 314 U.S. adults with type 2 diabetes (T2DM) and low socioeconomic status (SES), only medication adherence was significantly associated with better glycaemic control after adjusting for other diabetes self-care behaviours, demographic and diabetes characteristics. Medication adherence may be the most important self-care behaviour for glycaemic control among adults with T2DM and low SES. Focused efforts to improve medication adherence. among low-SES patient populations may improve glycaemic control.

  7. Case Reports

    1. Prolonged disease control with MEK inhibitor in neurofibromatosis type I-associated glioblastoma

      M. Ameratunga, G. McArthur, H. Gan and L. Cher

      Article first published online: 2 MAR 2016 | DOI: 10.1111/jcpt.12378

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      Neurofibromatosis type I (NF1) is associated with overactivation of the RAS-MAPK pathway. We describe a case of a patient with NF1 associated glioblastoma who responded to the MEK inhibitor trametinib.

  8. Original Articles

    1. Genetic determinants of lipid-lowering response to atorvastatin therapy in an Indian population

      P. Kadam, T. F. Ashavaid, C. K. Ponde and R. M. Rajani

      Article first published online: 2 MAR 2016 | DOI: 10.1111/jcpt.12369

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      Genetic variations in CYP7A1, CYP3A4, SLCO1B1 and ABCB1 are associated with the variable response to atorvastatin therapy in terms of LDL-cholesterol lowering.

  9. Case Reports

    1. You have free access to this content
      Non-HIV-associated Kaposi sarcoma in an immunosuppressed melanoma patient treated with dabrafenib

      S. Parakh, M. Goh and M. C. Andrews

      Article first published online: 28 FEB 2016 | DOI: 10.1111/jcpt.12366

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      Kaposi sarcoma (KS) is an uncommon neoplasm often associated with immunosuppression. BRAF inhibitor therapy of advanced melanoma frequently causes cutaneous toxicity, including painful plantar hyperkeratosis. We demonstrate the potential for these conditions to be confused, leading to a delay in specific management.

    2. Ceftriaxone-associated renal toxicity in adults: a case report and recommendations for the management of such cases

      W. Shen-hua, M. Fan-yi, Z. Qing-ling, Z. Li-na and M. Li-jun

      Article first published online: 23 FEB 2016 | DOI: 10.1111/jcpt.12358

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      Ceftriaxone-associated urolithiasis and PARF in adults is exceedingly rare and perhaps underappreciated. The ceftriaxone-associated urolithiasis has loose texture, which results in its radiolucent nature. Treatment should be optimized, including prompt J stent insertions by cystoscopy.

    3. ‘On-demand’ romiplostim therapy in immune thrombocytopenia

      M. Mitrovic, I. Elezovic and N. Suvajdzic-Vukovic

      Article first published online: 6 FEB 2016 | DOI: 10.1111/jcpt.12359

  10. Pharmacokinetics

    1. Lack of a pharmacokinetic drug–drug interaction between lithium and valproate when co-administered with aripiprazole

      D. W. Boulton, G. D. Kollia, S. Mallikaarjun and D. M. Kornhauser

      Article first published online: 14 MAY 2012 | DOI: 10.1111/j.1365-2710.2012.1331.x


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