Journal of Clinical Pharmacy and Therapeutics

Cover image for Vol. 40 Issue 5

Edited By: A. Li Wan Po

Impact Factor: 1.668

ISI Journal Citation Reports © Ranking: 2014: 170/254 (Pharmacology & Pharmacy)

Online ISSN: 1365-2710

Virtual Issue: Pharmacogenetics and Personalised Medicine

Most drugs are effective in only a proportion of patients and a drug, safe for most patients, can be potentially lethal for a few. Pharmacogenetics research aims to identify genetic markers that are useful for identifying the more likely responders. Individualising treatment based on personal biomarkers such as genetic polymorphisms is referred to as personalised medicine. In this virtual issue we highlight some of the recent developments in pharmacogenetics and personalised medicine by highlighting some recent articles published in the Journal Of Clinical Pharmacy and Therapeutics (Please also see latest Editorial).

Psychotherapy as an epigenetic 'drug': psychiatric therapeutics target symptoms linked to malfunctioning brain circuits with psychotherapy as well as with drugs, SM Stahl

Role of epigenetics in pharmacotherapy, psychotherapy and nutritional management of mental disorders, J Peedicayil

CYP4F2 gene polymorphism as a contributor to warfarin maintenance does in Japanese subjects, K Nakamura, K Obayashi, T Arak,i et al

Warfarin therapeutic monitoring: is 70% time in the therapeutic range the best we can do? E Lader, N Martin, G Cohen, et al

Distribution of CYP2C19*17 allele and genotypes in an Indian population, D Anichavezhi, US Chakradhara Rao, DG Shewade, R Krishnamorrthy, C Adithan

The roles of GSTM1 and GSTT1 null genotypes and other perdictors in anti-tuberculosis drug-induced liver injury, TP Monteiro, KB El-Jaick, AL Jeovanio-Silva, et al

Serum dextromethorphan/dextrorphan metabolic ratio for CYP2D6 phenotyping in clinical practice, J Jurica, R Bartecek, A Zourkova, et al

The pharmacokinetics of fluconazole in healthy Chinese adult volunteers: influence of ethnicity and gender, T Guo, WJ Sun, DY Xia, LS Zhao

Influence of CYP2C9 and CYP2C19 genetic polymorphisms on pharmacokinetics and pharmacodynamics of gliclazide in healthy Chinese Han volunteers, H Shao, XM Ren, NF Liu, et al

Interactions between CYP7A1A-204C and ABCG8 C1199A polymorphisms on lipid lowering with atorvastatin, KK Wei, LR Zhang, Y Zhang, XJ Hu

Predictability of individualized dosage regimens of carbamazepine and valproate mono- and combination therapy, IB Bondareva, RW Jelliffe, OV Andreeva, KI Bondareva