Journal of Viral Hepatitis

Cover image for Vol. 23 Issue 6

Edited By: Editor-In-Chief: Graham Foster US Editor: Mark Sulkowski European Editors: Peter Karayiannis and Mark Thursz

Impact Factor: 3.909

ISI Journal Citation Reports © Ranking: 2014: 10/33 (Virology); 19/78 (Infectious Diseases); 20/76 (Gastroenterology & Hepatology)

Online ISSN: 1365-2893

Author Guidelines

Submission is considered on the condition that papers are previously unpublished, are not offered simultaneously elsewhere, that all authors (defined below) have read and approved the content, that authors have declared all competing interests and the work has been conducted under internationally accepted ethical standards after relevant ethical review.

The editorial and peer review process is independent of the publisher. Whenever these are relevant to the content being considered or published, the editors and editorial board declare their interests and affiliations. To view a biography of the Editors and their disclosures, click on the Editor's name.

Howard Thomas

Peter Karayiannis

Manuscripts will be considered for publication in the form of original articles, reviews, short rapid communications and letters. Letters to the Editor are possible and encouraged. Papers accepted must be licensed for publication in the Journal of Viral Hepatitis and the copyright form must be completed for every accepted paper (see below). Authors will be required to transfer copyright for their paper to Wiley-Blackwell. Copyright transfer is a condition of publication.

Online Open
OnlineOpen is available to authors of primary research articles who wish to make their article available to non-subscribers on publication, or whose funding agency requires grantees to archive the final version of their article. With OnlineOpen, the author, the author's funding agency, or the author's institution pays a fee to ensure that the article is made available to non-subscribers upon publication via Wiley InterScience, as well as deposited in the funding agency's preferred archive. For the full list of terms and conditions, see

Prior to acceptance there is no requirement to inform an Editorial Office that you intend to publish your paper OnlineOpen if you do not wish to. All OnlineOpen articles are treated in the same way as any other article. They go through the journal's standard peer-review process and will be accepted or rejected based on their own merit.

Manuscripts concerned with human studies must contain statements indicating that informed, written consent has been obtained, that studies have been performed according to the World Medical Association Declaration of Helsinki and that the procedures have been approved by a local ethics committee. If individuals might be identified from a publication (e.g. from images) authors must obtain explicit consent from the individual.

Authors are required to disclose financial interests (e.g. employment, significant share ownership, patent rights, consultancy, research funding, etc.) in any company or institution that might benefit from their publication. All authors must provide details of any other potential competing interests of a personal nature that readers or editors might consider relevant to their publication. A completed CoI form must accompany every accepted paper (see below)

Authors must fulfil the following three criteria
• substantial contributions to research design, or the acquisition, analysis or interpretation of data
• drafting the paper or revising it critically
• approval of the submitted and final versions

Clinical trials
Clinical trials should be registered and publications must include the registration number and name of the trial register. If not available, please provide an explanation.
All articles are subject to review by experienced referees. The editors judge manuscripts suitable for publication. All decisions made by the editors are final.
Material accepted for publication is copy-edited and typeset. Proofs are then sent to contributors for a final check, but extensive changes to the proofs may be charged to the contributors.

Over the past few years, The Journal of Viral Hepatitis has become one of the leading journals in the field of virology and infectious disease. This is reflected by the steadily increasing number of high-quality manuscripts submitted to the Journal. With the exception of invited reviews, the Editors have decided to restrict the length of a manuscript to 4000 words, excluding acknowledgements and disclosures, references, tables, figure and table legends and figures, and to limit the number of figures and tables to a maximum of six items in the print edition of the Journal (e.g. four figures and two tables) in normal circumstances, with any additional material published online as supplementary material.  Manuscripts that do not meet these formal criteria will be returned for reformatting, which will delay submission.  Exceptions to these guidelines may be made in certain circumstances, at the discretion of the Editors.  If you require an exemption, please indicate this in your cover letter. The length of invited review articles remains at 5000 words and 50 references.

Guidelines for Cover Submissions
If you would like to send suggestions for artwork related to your manuscript to be considered to appear on the cover of the journal, please follow these general guidelines.

Article types
The reviews are focused topical accounts that highlight new and/or controversial areas.  The length of the review article is typically limited to 5000 words and 50 references. All reviews are subject to review by experienced referees. The Journal welcomes un-solicited reviews, but reserves the right to reject these without formal review.

Original articles
Original articles describe the results of basic or clinical studies, clinical trials or significant case reports.

Rapid communications
Manuscripts submitted for the “short communications” section should be no more than 1,500 words in total, include only one figure and a maximum of 8 references. They will be reviewed and accepted by the Editors on the basis of their outstanding scientific value and the presentation of novel insights into health or disease.  “short communication” articles will be only accepted with minor changes. Publication will be in the next available issue with the aim to publish the manuscript about two months after submission. The Editors reserve the right to reject the manuscript without formal review. Rejection for inclusion in the “short communications” section does not disqualify for resubmission as an original article.

Letters to the Editors
Letters to the Editors offer opinions on papers published in the Journal of Viral Hepatitis. Text should not exceed 400 words, and include no more than 5 references. Letters commenting on papers are sent to the authors of those papers for a response. Letters are selected for their importance, relevance, and originality; not all letters submitted can be published.

Book reviews and Case reports
The Journal of Viral Hepatitis does not publish Book Reviews and Case Reports.

Help for authors
Pre-submission English-language editing
Authors for whom English is a second language may choose to have their manuscript professionally edited before submission to improve the English. A list of independent suppliers of editing services can be found at All services are paid for and arranged by the author, and use of one of these services does not guarantee acceptance or preference for publication.

Digital artwork preparation
Guidance on the preparation and submission of figures, links to useful websites and access to both the Wiley-Blackwell house and journal-specific style guides can be found at

Acceptable file formats
Text: Manuscript should be submitted as one text file in either Word document (.doc), or RTF (.rtf).  Do not submit your file as a PDF.
Tables: Should form an integral part of the text file. Tables submitted as photographs or graphics will be rejected and delay the submission process.
Figures: You are required to upload high resolution graphics files. Micrographs (tone) should be supplied as TIFF (.tif); labelled micrographs (combination) or charts/ graphs/ diagrams (line) can be supplied as a TIFF or EPS (.eps) format.  Details of how to prepare figures can be found at http://authorservices.wiley/bauthor/illustration.asp
Figures for review must be uploaded separately and conform to the same standards as the Figures for publication.  They should not be embedded into the text of your initial submission.

The Journal of Viral Hepatitis only accepts submission at This enables rapid and effective peer review. Contributions will be acknowledged automatically by the editors and assigned a unique manuscript number that must be quoted on correspondence. Papers and reviews are refereed by experts in the field; the Editors reserve the right to reject an article without review.
Full upload instructions and support are available online from the submission site via the “Get help Now” button. Please submit your covering letter or comments to the editor as well as the names of potential referees when prompted online.

The editors have designated three types of revision for manuscripts in the Journal:
Minor revisions: these in general require only changes to the manuscript or easily conducted experiments.  Revised manuscripts must be submitted in their final form no later than four weeks of receipt of a revision letter from the Editor.
Major revisions: these require changes to the manuscript and significant additional experiments.  Revised manuscripts must be submitted in their final form within three months of receipt of a revision letter from the editor.
Resubmission: these  require extensive revision, with new experiments and major re-writing.  Revised manuscripts must be submitted in their final form within four months of receipt of a revision letter from the Editor.  
In all cases, resubmissions after the allotted time will be considered as new submissions. 

Manuscripts should be typed in a standard, easy to read font, either 11 or 12 point in size. Manuscripts should be double-spaced, with 2.5cm (1 inch) margins on all sides and run in one single column. Please ensure that you have turned “track changes off” and removed any reviewing notes from your manuscripts else these will be visible throughout the review process. Place the page number and first authors last name in the upper right-hand corner of each page.
Reviews should be divided onto the following sections and appear in the following order: (1)  title page (with short running page heading, title, authors names and affiliations), (2) abstract and keywords, (3) body of the article, (4)  acknowledgments and disclosures; (5) references, (6) tables, (7) figure legends, and (8) figures.
Original articles should be divided into the following sections and appear in the following order: (1) title page (with short running page heading, title, authors names and affiliations) (2) abstract and keywords, (3) Introduction, (4) materials and methods, (5) results, (6) discussion, (7) acknowledgements and disclosures, (8) references, (9) appendices, (10) supplementary material, (11) tables, (12) figure legends, and (13) figures.

Title Page
On the title page provide the complete title and a running title (not to exceed 45 characters and spaces). List each contributor's name and institutional affiliation. Provide the name, postal and e-mail address, fax and telephone number of the contributor responsible for the manuscript and proofs. This is the person to whom all correspondence and reprints will be sent. The corresponding author is responsible for keeping the Editorial office updated with any change in details until the paper is published.

Abstract and Key Words
The abstract must not exceed 250 words. It should summarize the aim of the study and describe the work undertaken, results and conclusions. In addition, you should list up to six key words in alphabetical order. For ideas on optimising your abstract, see here.

This section should not exceed more than 500 words and should not have a separate heading. The Introduction should briefly discuss the objectives of the study and provide the background information to explain why the study was undertaken, and what hypotheses were tested.

Materials and methods
Animal preparation and experimentation should cite the approving governing body. Equipment and apparatus should cite the make and model number and the company name and address (town, county, country) at first mention.
Give all measurements in metric units and use negative indexing (mg mL–1, not mg/mL). Use generic names of drugs. Symbols, units and abbreviations should be expressed as Système International (SI) units. In exceptional circumstances, others may be used, provided they are consistent. Apply to the editorial office for advice.

Tables and text should not duplicate each other.

This section should not exceed more than 1,500 words and should be concise. The Discussion should include a brief statement of the principal findings, a discussion of the validity of the observations, a discussion of the findings in light of other published work dealing with the same or closely related subjects, and a statement of the possible significance of the work. Authors are encouraged to conclude with a brief paragraph that highlights the main findings of the study.

Acknowledgements and disclosures
It is the duty of authors to acknowledge funding sources, technical assistance, provision of materials or reagents and other matters that might pertain to the paper.  Authors must acknowledge individuals who do not qualify as authors but who contributed to the research.  If the work was sponsored by an organization or industry, it is essential this be declared and the authors need to indicate that they had complete access to the data that supports the publication.  If the paper was written by a professional medical writer, this must be declared.
Please read the following statements, adding those sections which are relevant at the end of your submitted manuscript under a heading 'Statement of Interests'.  

1.     Authors' declaration of personal interests:
(i) [Name of individual] has served as a speaker, a consultant and an advisory board member for [names of organizations], and has received research funding from [names of organization].
(ii) [Name of individual] is an employee of [name of organization].
(iii) [Name of individual] owns stocks and shares in [name of organization].
(iv) [Name of individual] owns patent [patent identification and brief description].

2.     Declaration of funding interests:
(i) This study was funded [in part or in full] by [insert name of funding organization and provide funding identification numbers], grant number [insert grant or other identification number].
(ii) The [writing or preparation] of this paper was funded in part by [insert name of funding organization].
(iii) Initial data analyses were undertaken by [name of individuals if not listed as authors] who are employees of [name company] and received funding from [insert name of funding organization].
(iv) Writing support was provided by [insert name of individual(s)] of [name company] and funded by [insert name of funding organization]. Manuscript Style

The reference style is Vancouver (numbered). References must be numbered consecutively and cited in the text using arabic numerals within parentheses. The reference list should conform to the style used by the National Library of Medicine and Index Medicus. Work that has not been accepted for publication should not appear in the reference list. It may be cited in the text as unpublished data.
We recommend the use of a tool such as Reference Manager for reference management and formatting.
Reference Manager reference styles can be searched for here:

List all authors when six or fewer; when seven or more, list only the first three and add et al. Journal titles should be cited in full:
Caniano DA, Kanoti GA. Newborns with massive intestinal loss: difficult choices. N Engl Med 1988; 318: 70–87.

Books and Monographs
Personal author
Bateson M, Bouchier I. Clinical Investigation and Function, 2nd edn. Oxford: Blackwell Scientific Publications Ltd, 1981.
Corporate author
The Geological Society. List of serial publications held in the library of the Geological Society, London. Oxford: Blackwell Scientific Publications Ltd, 1987.
Editor, Compiler, Chairman as author
Booth CC, Neal AB, eds. Disorders of the Small Intestine. Oxford: Blackwell Scientific Publications Ltd, 1985.
Chapter in book
Morson BC, Dawson IMP. Mechanical disorders In: Morson BC, Dawson IMP, eds. Gastrointestinal Pathology, 2nd edn. Oxford: Blackwell Scientific Publications Ltd, 1979: 267-71.

Include in the manuscript a list of new or special abbreviations along with the spelled out form or definition. For commonly accepted abbreviations, word usage, symbols, etc., authors are referred to the CBE Style Manual published by the American Institute of Biological Sciences or Units, Symbols and Abbreviations published by the Royal Society of Medicine.

Tables should be numbered consecutively within the text. Tables and text should not duplicate each other. If possible, hold tables to one standard manuscript page; if the table continues past one page, repeat all column headings and the stub (left-hand column). Explain all abbreviations in a footnote. Provide a number and title for each table. Regardless of authorship or publisher, permission must be received in writing for its use if a table has been previously published. Include an acknowledgement of the original source in a footnote. Tables should not be submitted as photographs or graphics files.

Labelling should be in 8pt Helvetica or Arial. Figure sections should be designated with upper case letters. Magnification (scale) bars should be given on electron and light micrographs. Details of the magnification bar should be noted in the figure legends.  Authors may be asked to contribute to printing costs if the space requested for illustrations is considered too large or if colour photographs are requested.

Figure and table legends
Cite all tables and figures in the text, numbering them sequentially as they are cited.
Each figure must have a corresponding legend. The legend must be numbered with an arabic number that corresponds to the illustration as it appears in the text. Each should begin with a short title for the figure. Legends to tables (where necessary) and figures should contain sufficient information to be understood without reference to the text. Explain all symbols, arrows, numbers, or letters used in the figure and provide information on scale and/or magnification. For photomicrographs, include information on the method of staining or preparation.

Supplementary material
Quantitative or qualitative data too extensive for inclusion in the print edition of the Journal may be presented in the online edition, as supplementary material. It must be included as part of the original submission and will be reviewed as an integral part of the paper. The availability of supplementary material should be indicated in the main manuscript, to appear after the references at the end of the paper, providing titles of figures, tables, etc. formatted as if the material was to appear in the print edition. We welcome audio and video material, if relevant to your paper. Full details on how to submit supplementary material, including videos, can be found at

Supporting Documents
These forms must accompany your accepted manuscript and are a condition of publication.
All forms are available to download from the The Journal of Viral Hepatitis submission site at They can either be uploaded as supporting documents to your manuscript (preferred) or where this is not possible, faxed to the editorial office (Fax): +44 (0) 208 220 7791.

Copyright Transfer Agreement
If your paper is accepted, the author identified as the formal corresponding author for the paper will receive an email prompting them to login into Author Services; where via the Wiley Author Licensing Service (WALS) they will be able to complete the license agreement on behalf of all authors on the paper.

For authors signing the copyright transfer agreement
If the OnlineOpen option is not selected the corresponding author will be presented with the copyright transfer agreement (CTA) to sign. The terms and conditions of the CTA can be previewed in the samples associated with the Copyright FAQs below:

CTA Terms and Conditions

For authors choosing OnlineOpen
If the OnlineOpen option is selected the corresponding author will have a choice of the following Creative Commons License Open Access Agreements (OAA):

Creative Commons Attribution Non-Commercial License OAA

Creative Commons Attribution Non-Commercial -NoDerivs License OAA

To preview the terms and conditions of these open access agreements please visit the Copyright FAQs hosted on Wiley Author Services and visit

If you select the OnlineOpen option and your research is funded by The Wellcome Trust and members of the Research Councils UK (RCUK) you will be given the opportunity to publish your article under a CC-BY license supporting you in complying with Wellcome Trust and Research Councils UK requirements. For more information on this policy and the Journal’s compliant self-archiving policy please visit:

For RCUK and Wellcome Trust authors click on the link below to preview the terms and conditions of this license:

Creative Commons Attribution License OAA

To preview the terms and conditions of these open access agreements please visit the Copyright FAQs hosted on Wiley Author Services and visit

Conflict of Interest statement
The Journal insists on full disclosure of competing financial and other interests from all authors.  This is mandatory and a condition of publication. A completed CoI form must accompany every accepted paper.

Colour Work Agreement
It is Journal policy to charge authors for colour reproduction. If you wish your figures to be reproduced in colour, you must complete and return a Colour Work Agreement form (CWAF) before your paper can be published.

Article Tracking
Author Services enables authors to track their article – once it has been accepted – through the production process to publication online and in print. Authors can check the status of their articles online and choose to receive automated e-mails at key stages of production. The author will receive an e-mail with a unique link that enables them to register and have their article automatically added to the system. Please ensure that a complete e-mail address is provided when submitting the manuscript. Visit for more details on online production tracking and for a wealth of resources including FAQs and tips on article preparation, submission and more.

Proofs will be available as a PDF to download from our e-proofing website. Full instructions will be sent via email notification when the proof is ready for collection. Adobe Acrobat Reader is required in order to read this file, which can be downloaded (free of charge) from
In your absence, please arrange for a named colleague to correct on your behalf. Major alterations will be charged to the author and can delay publication.

Proofs must be returned by fax or email only to the production editor within three days of receipt of notification. We cannot accept proofs by post - and any late return of proofs will lead to delayed publication of your paper to avoid any delay in publication of an issue. Authors will receive one set of proofs only.

A PDF is provided upon publication to the corresponding author. Paper offprints can be purchased prior to print publication from

Archiving Policy
Unless specifically requested at submission, the publisher will dispose of all material submitted 2 months post publication.