High osmolarity glycerol response PtcB phosphatase is important for Aspergillus fumigatus virulence
Lizziane K. Winkelströter, Vinícius Leite Pedro Bom, Patrícia Alves de Castro, Leandra Naira Zambelli Ramalho, Maria Helena S. Goldman, Neil Andrew Brown, Ranjith Rajendran, Gordon Ramage, Elodie Bovier, Thaila Fernanda dos Reis, Marcela Savoldi, Daisuke Hagiwara and Gustavo H. Goldman
Article first published online: 11 FEB 2015 | DOI: 10.1111/mmi.12919
Aspergillus fumigatus is a fungal pathogen that is capable of adapting to different host niches and avoiding host defenses. We have recognized PtcB as a protein phosphatase involved in the HOG (High Osmolarity Glycerol response) pathway. The ΔptcB mutant has both increased phosphorylation of the p38 MAPK (SakA) and expression of osmo-dependent genes. The ΔptcB strain was avirulent in a murine model of invasive pulmonary aspergillosis, stressing the importance of the HOG pathway in the regulation of pathogenicity and virulence.