Trypanosomatid parasites rescue heme from endocytosed hemoglobin through lysosomal HRG transporters
María Cabello-Donayre, Sophie Malagarie-Cazenave, Jenny Campos-Salinas, Francisco J. Gálvez, Alba Rodríguez-Martínez, Estela Pineda-Molina, Lina M. Orrego, Marta Martínez-García, María P. Sánchez-Cañete, Antonio M. Estévez and José M. Pérez-Victoria
Version of Record online: 8 JUL 2016 | DOI: 10.1111/mmi.13430
An Achilles' heel of pathogenic trypanosomatid parasites is their absolute dependence on scavenging heme from their human hosts. Here, we unravel the mechanism used by Trypanosoma brucei (responsible for sleeping sickness) and Leishmania (leishmaniasis) to rescue heme from host hemoglobin. By using homologous and heterologous systems we show evidences strongly suggesting that parasite HRG transporters are responsible for heme transport from the endolysosomal compartment, where endocytosed hemoglobin is degraded, to the cytosol.