The Aspergillus fumigatus SchASCH9 kinase modulates SakAHOG1 MAP kinase activity and it is essential for virulence
Patrícia Alves de Castro, Thaila Fernanda dos Reis, Stephen K. Dolan, Adriana Oliveira Manfiolli, Neil Andrew Brown, Gary W. Jones, Sean Doyle, Diego M. Riaño-Pachón, Fábio Márcio Squina, Camila Caldana, Ashutosh Singh, Maurizio Del Poeta, Daisuke Hagiwara, Rafael Silva-Rocha and Gustavo H. Goldman
Version of Record online: 7 OCT 2016 | DOI: 10.1111/mmi.13484
Aspergillus fumigatus is a major opportunistic pathogen and allergen of mammals. We characterized the A. fumigatus Sch9 homologue (SchA) showing that SchA is important for integrating calcium signalling, sphingolipid biosynthesis, hyperosmotic stress, and was involved in iron metabolism. The ΔschA was avirulent in a low dose murine infection model. SchA represents an important protein kinase at the interface between osmotic stress, iron sensing, sphingolipid biosynthesis, calcium metabolism, and pathogenicity in this important opportunistic human pathogen.