3D Interactive Images
Mechanisms for maintaining cell shape in rod-shaped Gram-negative bacteria
Leon Furchtgott, Ned S. Wingreen and Kerwyn Casey Huang
When new insertion sites are chosen at random along the surface, severe bending and bulging results.
Uniform azimuthal and longitudinal density of insertion-site selection maintains rod shape.
Cell walls grown with uniform insertion to three times their original length, with insertional stretching ranging from - 10% (i.e. compression) to + 20%(x-axis) and inserted strand lengths ranging from 10 to 30 (y-axis).
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Model cells elongated using the uniform insertion model with L = 20 and 10% stretching are divided in half after each doubling of cell-wall material. The cell-wall networks for the first three generations are shown.
Cell wall grown to six times its original length.
Cell wall grown to two- and threefold its original mass, with significant bending and increases in local width. After threefold growth, the cell wall has almost completely lost its rod shape.
Crystal structures of DntR inducer binding domains in complex with salicylate offer insights into the activation of LysR-type transcriptional regulators
Laurence Devesse, Irina Smirnova,Rosa Lönneborg, Ulrike Kapp,Peter Brzezinski,Gordon A. Leonard, Cyril Diang
The DntR IBD primary salicylate binding site.
An interactive 3D-PDF image of the DntR IBD with ligand bound only in the IBC. The ligand is shown in van der Waals representation, carbon atoms in yellow, oxygen atoms red.
The secondary salicylate binding site.
An interactive 3D-PDF image of the DntR IBD showing the locations of both the primary and secondary salicylate binding sites indentified.
Architecture and assembly of the Gram-positive cell wall
Morgan Beeby, James C. Gumbart, Benoît Roux and Grant J. Jensen
Relaxation of a circumferential peptidoglycan fragment. Note circumferential peptidoglycan thickens and curls considerably upon relaxation.
Peptidoglycan fragment from the all-at-once perpendicular model as originally proposed before and after relaxation.
|Fragment grown using an inside-to-outside perpendicular assembly model. For all relaxed fragments, coloured cylinders represent changes|
in distances between two NAM residues on the inner and outer surfaces; cylinder diameter and intensity of shading is proportional to change
in distance upon relaxation, with red representing contraction and blue representing expansion.