Neurogastroenterology & Motility

Cover image for Vol. 27 Issue 7

Early View (Online Version of Record published before inclusion in an issue)

Edited By: Magnus Simren, Gary Mawe and Jim Galligan

Impact Factor: 3.587

ISI Journal Citation Reports © Ranking: 2014: 25/76 (Gastroenterology & Hepatology); 44/192 (Clinical Neurology); 85/252 (Neurosciences)

Online ISSN: 1365-2982


  1. 1 - 28
  1. Original Articles

    1. The Experience Sampling Method - a new digital tool for momentary symptom assessment in IBS: an exploratory study

      Z. Mujagic, C. Leue, L. Vork, R. Lousberg, D. M. A. E. Jonkers, D. Keszthelyi, M. A. Hesselink, T. J. C. van Schagen, J. van Os, A. A. M. Masclee and J. W. Kruimel

      Article first published online: 22 JUN 2015 | DOI: 10.1111/nmo.12624

      Thumbnail image of graphical abstract

      IBS patients report higher scores for abdominal pain in retrospective questionnaires, with a tendency of peak reporting, compared to momentary symptom assessment. Experience Sampling Method is a new digital tool for momentary symptom assessment in IBS and can provide more insight in the fluctuation of IBS symptoms during the day.

    2. Characterization of idiopathic esophagogastric junction outflow obstruction

      F. B. van Hoeij, A. J. P. M. Smout and A. J. Bredenoord

      Article first published online: 21 JUN 2015 | DOI: 10.1111/nmo.12625

      Thumbnail image of graphical abstract

      We describe a cohort of patients with EGJ outflow obstruction. We aimed for a better understanding of this rare disease and a more evidence-based treatment. A substantial part of patients has no symptoms correlating to outflow obstruction or no stasis on barium esophagography. Treated patients showed a beneficial response to treatment with botox injections. A small part of patients develops achalasia.

    3. Intestinal gas content and distribution in health and in patients with functional gut symptoms

      R. A. Bendezú, E. Barba, E. Burri, D. Cisternas, C. Malagelada, S. Segui, A. Accarino, S. Quiroga, E. Monclus, I. Navazo, J.-R. Malagelada and F. Azpiroz

      Article first published online: 21 JUN 2015 | DOI: 10.1111/nmo.12618

      Thumbnail image of graphical abstract

      Intestinal gas content and distribution was measured by abdominal CT imaging in 112 patients with functional bowel disorders complaining of abdominal bloating, the normal range was defined in 37 healthy subjects by machine learning techniques. No abnormalities were found when scans were taken in the moment patients were asymptomatic (n = 88); however, when scans coincided with symptoms, a substantial proportion of patients (21 of 106) were outside the normal range.

    4. Self-reported lactose intolerance in clinic patients with functional gastrointestinal symptoms: prevalence, risk factors, and impact on food choices

      X. Zheng, H. Chu, Y. Cong, Y. Deng, Y. Long, Y. Zhu, D. Pohl, M. Fried, N. Dai and M. Fox

      Article first published online: 19 JUN 2015 | DOI: 10.1111/nmo.12602

      Thumbnail image of graphical abstract

      (1) In a lactase deficient population, approximately half of patients attending clinic with functional gastrointestinal symptoms reported intolerance to dairy products. (2) SLI did not predict the occurrence of symptoms by 20 g Lactose HBT. (3) SLI subjects avoided lactose intake from dairy products and reduced intake also of other foods, such as legumes and dried fruit, known to cause bloating and flatulence. (4) Independent of psychosocial factors, the presence of food intolerance impacted on quality-of-life.

    5. Increased attentional network functioning related to symptom severity measures in females with irritable bowel syndrome

      C. S. Hubbard, J. Hong, Z. Jiang, B. Ebrat, B. Suyenobu, S. Smith, N. Heendeniya, B. D. Naliboff, K. Tillisch, E. A. Mayer and J. S. Labus

      Article first published online: 19 JUN 2015 | DOI: 10.1111/nmo.12622

      Thumbnail image of graphical abstract

      Our results indicate that female IBS patients show altered attentional network functioning that was associated with measures of symptom-related anxiety, hypervigilance, and visceral sensitivity.

    6. Reduction of hydrogen sulfide synthesis enzymes in the esophagus of patients with achalasia: effect of hydrogen sulfide in achalasia

      L. Zhang, W. Zhao, Z. Zheng, T. Wang, C. Zhao, G. Zhou, H. Jin and B. Wang

      Article first published online: 18 JUN 2015 | DOI: 10.1111/nmo.12621

      Thumbnail image of graphical abstract

      The pathogenesis of achalasia is not clear, but current opinion holds that it likely involves the lack of inhibitory transmitters. We find that H2S synthesis enzymes can be detected in the human esophagus and are significantly reduced in achalasia patients. Furthermore, H2S inhibits esophageal contractile activity concentration-dependently.

    7. Patients with refractory reflux symptoms often do not have GERD

      T. V. K. Herregods, M. Troelstra, P. W. Weijenborg, A. J. Bredenoord and A. J. P. M. Smout

      Article first published online: 18 JUN 2015 | DOI: 10.1111/nmo.12620

      Thumbnail image of graphical abstract

      In patients with typical reflux symptoms that persist despite proton pump inhibitors (PPIs) it is sometimes overlooked that treatment fails due to the presence of other disorders than gastroesophageal reflux disease (GERD). In our study, approximately one-third of the patients referred with refractory reflux symptoms suffer from disorders other than GERD, predominantly functional heartburn. This explains, at least partly, why many patients will not benefit from acid inhibitory treatment.

  2. Review Articles

    1. Targeting tachykinin receptors for the treatment of functional gastrointestinal disorders with a focus on irritable bowel syndrome

      M. Corsetti, F. Akyuz and J. Tack

      Article first published online: 18 JUN 2015 | DOI: 10.1111/nmo.12616

      Thumbnail image of graphical abstract

      This article reviews the current literature concerning the role of tachykinins in the GI tract in physiological and pathological conditions and their potential relevance for the treatment of functional GI disorders with particular reference to the irritable bowel syndrome. Pharmacodynamic studies have suggested a role for antagonism of NK2 receptors in modulation of GI chemical-induced altered motility and of stress-induced altered bowel habits in humans and recent phase 2 clinical trials have reported efficacy in the treatment of symptoms of D-IBS. If ongoing phase 3 studies confirm these data, this will generate a treatment option for patients with D-IBS, where therapeutic possibilities are still limited.

  3. Original Articles

    1. Lactobacillus rhamnosus GG supernatant upregulates serotonin transporter expression in intestinal epithelial cells and mice intestinal tissues

      Y. M. Wang, X. Z. Ge, W. Q. Wang, T. Wang, H. L. Cao, B. L. Wang and B. M. Wang

      Article first published online: 18 JUN 2015 | DOI: 10.1111/nmo.12615

      Thumbnail image of graphical abstract

      LGG is one of the best-studied Lactobacillus strains in clinical trials, which can effectively reduce the incidence of diarrhea without side effects. SERT mRNA and SERT-P levels in LGG-s treated HT-29, Caco-2 cells, and intestinal epithelial cells were higher than those in the control. LGG-s can upregulate SERT mRNA and SERT-P levels in intestinal epithelial cells and mice intestinal tissues. LGG-s might improve intestinal motility and gastrointestinal sensation by regulating SERT expression.

    2. High-resolution impedance manometry measurement of bolus flow time in achalasia and its correlation with dysphagia

      Z. Lin, D. A. Carlson, K. Dykstra, J. Sternbach, E. Hungness, P. J. Kahrilas, J. D. Ciolino and J. E. Pandolfino

      Article first published online: 18 JUN 2015 | DOI: 10.1111/nmo.12613

      Thumbnail image of graphical abstract

      A new metric, bolus flow time (BFT) across the EGJ devised using HRIM was significantly reduced in all subtypes of achalasia and complementary to the IRP as a diagnostic discriminant in equivocal achalasia cases. Additionally, BFT had a more robust correlation with dysphagia severity compared to other metrics of EGJ function. Concordance of HRM metrics in the context of dysphagia severity. IRP is on the X-axis, BFT is on the y-axis, and the corresponding supine values of the 60 achalasia patients are plotted. The circles are colored to represent gradations of IDQ score (white <10, gray 10-25, black >25).

    3. Stimulation of synthesis and release of brain-derived neurotropic factor from intestinal smooth muscle cells by substance P and pituitary adenylate cyclase-activating peptide

      M. Al-Qudah, R. Alkahtani, H. I. Akbarali, K. S. Murthy and J. R. Grider

      Article first published online: 18 JUN 2015 | DOI: 10.1111/nmo.12604

      Thumbnail image of graphical abstract

      This study demonstrates that BDNF is present in smooth muscle cells of the longitudinal layer. The neuropeptides substance P and PACAP stimulate the synthesis and release of BDNF. BDNF then acts in an autocrine manner to augment cholinergic contraction of longitudinal smooth muscle.

    4. You have full text access to this OnlineOpen article
      Ghrelin enhancer, rikkunshito, improves postprandial gastric motor dysfunction in an experimental stress model

      Y. Harada, S. Ro, M. Ochiai, K. Hayashi, E. Hosomi, N. Fujitsuka, T. Hattori and K. Yakabi

      Article first published online: 18 JUN 2015 | DOI: 10.1111/nmo.12588

      Thumbnail image of graphical abstract

      Stress hormone urocortin1-induced gastric motility dysfunction was mediated by abnormal acylated gherlin dynamics. Supplementation of exogenous acylated ghrelin or enhancement of endogenous acylated ghrelin secretion by rikkunshito may be effective in treating functional gastrointestinal disorders.

    5. A novel association between COMT and BDNF gene polymorphisms and likelihood of symptomatic dysphagia in older people

      D. Nimmons, N. Pendleton, A. Payton, W. Ollier, M. Horan, J. Wilkinson and S. Hamdy

      Article first published online: 14 JUN 2015 | DOI: 10.1111/nmo.12609

      Thumbnail image of graphical abstract

      This study investigated whether COMT and BDNF genotype could predict dysphagia in an independently living, community- dwelling population of older people. COMT polymorphism rs165599 and BDNF polymorphism rs10835211 were found to be associated with dysphagia and a significant interaction was found between them (p = 0.028).

  4. Review Articles

    1. Drug-drug interactions in pharmacologic management of gastroparesis

      A. S. Youssef, H. P. Parkman and S. Nagar

      Article first published online: 8 JUN 2015 | DOI: 10.1111/nmo.12614

      Thumbnail image of graphical abstract

      Treatment of gastroparesis usually involves several pharmacologic agents which may trigger a pharmacokinetic-based drug-drug interaction leading to alteration in systemic levels and subsequent adverse drug reactions. A comprehensive literature review is presented for the reported drug-drug interactions in gastroparesis. Several potentially hazardous drug combinations were identified and their undesirable clinical outcomes are discussed. Modeling techniques that extrapolate in vitro data to in vivo exposure are useful tools to identify and evaluate putative drug-drug interactions.

  5. Original Articles

    1. Toll-like receptors 2 and 4 modulate the contractile response induced by serotonin in mouse ileum: analysis of the serotonin receptors involved

      R. Forcén, E. Latorre, J. Pardo, A. I. Alcalde, M. D. Murillo and L. Grasa

      Article first published online: 5 JUN 2015 | DOI: 10.1111/nmo.12619

      Thumbnail image of graphical abstract

      TLR2 and TLR4 signaling may modulate the spontaneous contractions and the serotonin contractile response in mice ileum by acting on 5-HT2, 5-HT3, 5-HT4, and 5-HT7 receptors.

  6. Review Articles

    1. Pathophysiology of gastroesophageal reflux disease: new understanding in a new era

      T. V. K. Herregods, A. J. Bredenoord and A. J. P. M. Smout

      Article first published online: 5 JUN 2015 | DOI: 10.1111/nmo.12611

      Thumbnail image of graphical abstract

      This review provides an overview of the current understanding of the pathophysiological mechanisms causing GERD and the factors which influence perception.

  7. Original Articles

    1. Impact of deep brain stimulation on pharyngo-esophageal motility: a randomized cross-over study

      S. Derrey, N. Chastan, D. Maltete, E. Verin, P. Dechelotte, R. Lefaucheur, F. Proust, P. Freger, A. M. Leroi, J. Weber and G. Gourcerol

      Article first published online: 5 JUN 2015 | DOI: 10.1111/nmo.12607

      Thumbnail image of graphical abstract

      In a randomized trial, we have investigated esophageal motility changes observed in Parkinsonian patient who underwent bilateral subthalamic stimulation. An increase in the distal contractility index and a decrease in the integrative relaxation pressure of the lower esophageal sphincter were found when the stimulator was on. This resulted in a decrease in the intrabolus pressure. These results suggest that the nigrostriatal-striatonigral loop is involved in the control of esophageal motility.

    2. Inter-rater reliability and validity of automated impedance manometry analysis and fluoroscopy in dysphagic patients after head and neck cancer radiotherapy

      M. M. Szczesniak, J. Maclean, T. Zhang, R. Liu, C. Cock, N. Rommel, T. I. Omari and I. J. Cook

      Article first published online: 31 MAY 2015 | DOI: 10.1111/nmo.12610

      Thumbnail image of graphical abstract

      The study evaluated the reliability and validity of pharyngeal pressure/impedance metrics, swallow risk index (SRI), and postswallow residue (iZn/Z). These measures of swallowing function have better inter-rater reliability than comparable fluoroscopically derived measures and are objective markers of clinically relevant features of disordered swallowing following head and neck cancer therapy.

    3. MeCP2 in the enteric nervous system

      G. Wahba, S. C. Schock, E. Claridge, M. Bettolli, D. Grynspan, P. Humphreys and W. A. Staines

      Article first published online: 31 MAY 2015 | DOI: 10.1111/nmo.12605

      Thumbnail image of graphical abstract

      This study aimed to investigate if MeCP2 is expressed in the human and murine ENS and at which stages of development it first appears. MeCP2 is expressed throughout development of the GI tract with appearance at or before E11.5 in mice, specifically in the enteric nervous tissue. This study opens the possibility for treatment of the GI dysfunction in Rett syndrome with peripheral acting drugs and growth factors.

    4. Visceral hypersensitivity in irritable bowel syndrome: evidence for involvement of serotonin metabolism – a preliminary study

      D. Keszthelyi, F. J. Troost, D. M. Jonkers, H. M. van Eijk, J. Dekker, W. A. Buurman and A. A.M. Masclee

      Article first published online: 31 MAY 2015 | DOI: 10.1111/nmo.12600

      Thumbnail image of graphical abstract

      The serotonin precursor 5-HTP induces a pronociceptive response, accompanied by an increase in systemic concentrations of serotonergic metabolites. These responses were most apparent in hypersensitive IBS patients.

    5. Esophagogastric junction morphology is associated with a positive impedance-pH monitoring in patients with GERD

      S. Tolone, C. de Cassan, N. de Bortoli, S. Roman, F. Galeazzi, R. Salvador, E. Marabotto, M. Furnari, P. Zentilin, S. Marchi, R. Bardini, G. C. Sturniolo, V. Savarino and E. Savarino

      Article first published online: 25 MAY 2015 | DOI: 10.1111/nmo.12606

      Thumbnail image of graphical abstract

      Esophagogastric junction (EGJ) morphology can play an important role in defense mechanism against reflux. Defining EGJ morphology with high-resolution manometry (HRM) may be useful to predict an abnormal impedance-pH testing in GERD. This study aims to establish a correlation between EGJ subtypes and different reflux parameters, detected during impedance-pH monitoring in GERD patients. EGJ morphology is depicted at HRM by evaluating the position of lower esophageal sphincter (LES) and crural diaphragm (CD). EGJ subtypes are classified as: Type I, no separation detectable between LES and CD; Type II, presence of minimal separation (>1 and <2 cm) between LES and CD; Type III, presence of separation ≥2 cm. Reflux parameters determined at impedance-pH monitoring are total number of reflux, total esophageal acid exposure time (AET) and symptom-reflux events association analysis. Our findings demonstrated that a gradual and significant increase in terms of esophageal AET, total number of reflux episodes and positive reflux-symptom association are observed when the separation between LES and CD becomes wider (Type II and III EGJ morphology). EGJ morphology may be useful to estimate an abnormal impedance-pH testing in patients with reflux symptoms. However, reflux monitoring remains mandatory to confirm the diagnosis of GERD.

    6. Postinfectious irritable bowel syndrome after travelers' diarrhea – a cohort study

      J. Schwille-Kiuntke, P. Enck, A. V. Polster, M. Gaile, P. G. Kremsner and P. Zanger

      Article first published online: 25 MAY 2015 | DOI: 10.1111/nmo.12601

      Thumbnail image of graphical abstract

      The study aims to assess the occurrence of PI-IBS in a cohort of patients with self-reported travelers' diarrhea (TD). Travelers suffering from TD were included in a cohort study, a follow-up was conducted after 1 year. Vomiting at the initial gastrointestinal infection and high somatization scores are risk factors for the development of postinfectious irritable bowel syndrome.

    7. The influence of physical strain on esophageal motility in healthy volunteers studied with gas-perfusion manometry

      S. Hoehne, A. Schneider, V. Hesse, U. Brosig and R. Finke

      Article first published online: 24 MAY 2015 | DOI: 10.1111/nmo.12587

      Thumbnail image of graphical abstract

      There is some evidence that physical exercise can affect the esophageal motility. However, it needs more examinations to verify these findings. Eight voluntary young adults were investigated simultaneously by bicycle ergometry and gas-perfusion esophageal manometry. It was found that high physical strain can affect the esophageal motility and induce a significant decrease of the contraction amplitude.

    8. Mast cell degranulation inhibits motor patterns of human ileum and sigmoid colon in vitro: relevance for postoperative ileus

      J. Rychter, O. Ortega, S. Berdun, C. Arenas, I. Lopez, F. Espin, P. Vergara and P. Clavé

      Article first published online: 13 MAY 2015 | DOI: 10.1111/nmo.12589

      Thumbnail image of graphical abstract

      Incubation of colonic circular muscle strips ex vivo with the mast cell degranulator c48/80 impairs spontaneous rhythmic phasic contractions (A) and contractions evoked by electric field stimulation (B). A preincubation with the mast cell stabilizer ketotifen or a protease inhibitor (data not shown) prevents this impairment demonstrating that mast cell products such as proteases can directly impair contractility of the human colonic circular muscle. Such an impairment is likely to be implicated in the pathophysiology of postoperative ileus which is accompanied by a potent, local release of mast cell mediators caused by surgical bowel handling.

    9. Plasma ghrelin and liquid gastric emptying in children with functional dyspepsia consistent with post-prandial distress syndrome

      N. M. Hijaz, C. A. Friesen, J. V. Schurman, R. E. Pearce and S. M. Abdel-Rahman

      Article first published online: 12 MAY 2015 | DOI: 10.1111/nmo.12591

      Thumbnail image of graphical abstract

      There are no pediatric studies that examined plasma ghrelin levels and their relation to liquid GE in children. Functional dyspepsia-PDS and control subjects underwent measurement of fasting and post-prandial plasma acyl and des-acyl ghrelin hormone at multiple time intervals. FD-PDS is associated with lower fasting and maximum AG concentrations and dampened AG flux. These data suggest a possible role for altered ghrelin physiology in the pathogenesis of PDS, however, whether that role is pathogenic or protective requires further investigation.

    10. Altered viscerotopic cortical innervation in patients with irritable bowel syndrome

      A. Irimia, J. S. Labus, C. M. Torgerson, J. D. Van Horn and E. A. Mayer

      Article first published online: 7 MAY 2015 | DOI: 10.1111/nmo.12586

      Thumbnail image of graphical abstract

      Visual representation of WM connections innervating S1 in a representative study patient. Depicted is a frontal view of the left and right postcentral gyri (red) together with the WM connections innervating S1. WM tracts connecting the postcentral gyri to the corticospinal tracts are drawn in bright green and highlighted by green arrows.

  8. Reviews Article

    1. Emerging treatments in Neurogastroenterology: Perspectives of guanylyl cyclase C agonists use in functional gastrointestinal disorders and inflammatory bowel diseases

      A. Jarmuż, M. Zielińska, M. Storr and J. Fichna

      Article first published online: 30 APR 2015 | DOI: 10.1111/nmo.12574

      Thumbnail image of graphical abstract

      Guanylyl cyclase C is involved in the maintenance of homeostasis in the intestines by regulation of water and electrolytes transport. Linaclotide, a guanylyl cyclase C agonist, was accepted by FDA and EMA as a therapeutic in irritable bowel syndrome and chronic idiopathic constipation. Results of the preclinical studies suggest that guanylyl cyclase C agonists may become efficient therapeutics in inflammatory bowel disease. Phase I of clinical trial for SP-333 in inflammatory bowel disease therapy was completed in December 2012.


  1. 1 - 28