Baseline features and differences in 48 week clinical outcomes in patients with gastroparesis and type 1 vs type 2 diabetes
K. L. Koch, W. L. Hasler, K. P. Yates, H. P. Parkman, P. J. Pasricha, J. Calles-Escandon, W. J. Snape, T. L. Abell, R. W. McCallum, L. A. Nguyen, I. Sarosiek, G. Farrugia, J. Tonascia, L. Lee, L. Miriel, F. Hamilton and For the NIDDK Gastroparesis Clinical Research Consortium (GpCRC)
Article first published online: 6 MAR 2016 | DOI: 10.1111/nmo.12800
This study defined similarities and differences in gastroparesis severity, healthcare utilization, psychological function, and quality of life in patients with type 1 (T1DM) and type 2 (T2DM) diabetes mellitus and gastroparesis. At baseline enrollment, T1DM patients had higher hemoglobin A1c levels and more severe emptying delays, but the severity of GI symptoms was similar to those of patients with T2DM and gastroparesis. After 48 weeks of follow-up, gastroparesis symptom scores significantly decreased in T2DM patients but not in T1DM patients despite increased use of prokinetic, acid suppressant, anxiolytic, and gastric electrical stimulation therapy in the T1DM group.