Validation of criteria for the definition of transient lower esophageal sphincter relaxations using high-resolution manometry
S. Roman, R. Holloway, J. Keller, F. Herbella, F. Zerbib, Y. Xiao, L. Bernard, A. J. Bredenoord, S. Bruley des Varannes, M. Chen, M. Fox, P. J. Kahrilas, R. K. Mittal, R. Penagini, E. Savarino, D. Sifrim, J. Wu, E. Decullier, J. E. Pandolfino and F. Mion
Version of Record online: 31 JUL 2016 | DOI: 10.1111/nmo.12920
A consensus definition of transient lower espohageal sphincter relaxation (TLESR) using high resolution manometry is proposed. TLESR is defined as LES relaxation occurring in absence of swallowing, lasting more than 10 seconds and associated with crural definition inhibition. Reflux on impedance, esophageal shortening, common cavity, upper esophageal sphincter relaxation without swallow and secondary peristalsis are alternate diagnostic criteria.