Neurogastroenterology & Motility

Cover image for Vol. 27 Issue 2

Early View (Online Version of Record published before inclusion in an issue)

Edited By: Magnus Simren and Gary Mawe

Impact Factor: 3.424

ISI Journal Citation Reports © Ranking: 2013: 21/75 (Gastroenterology & Hepatology); 46/194 (Clinical Neurology); 99/252 (Neurosciences)

Online ISSN: 1365-2982


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  1. Original Articles

    1. Hyperglycemia-induced small intestinal dysrhythmias attributed to sympathovagal imbalance in normal and diabetic rats

      X. Ouyang, S. Li, R. Foreman, J. Farber, L. Lin, J. Yin and J. D. Z. Chen

      Article first published online: 28 JAN 2015 | DOI: 10.1111/nmo.12506

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      This study suggests that hyperglycemia results in slow wave dysrhythmias in the small intestine. Impairment in autonomic functions is believed to play a role in hyperglycemia-induced slow wave dysrhythmias.

    2. Weak peristalsis with large breaks in chronic cough: association with poor esophageal clearance

      C. Almansa, J. A. Smith, J. Morris, M. D. Crowell, D. Valdramidou, A. S. Lee, K. R. DeVault and L. A. Houghton

      Article first published online: 27 JAN 2015 | DOI: 10.1111/nmo.12513

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      Gastroesophageal reflux plays an important role in chronic cough. This study shows that one-third of patients with chronic cough exhibit weak peristalsis with large breaks and that this esophageal motor disorder directly relates to poor bolus clearance of refluxate and swallowed liquids. These observations may have important implications for esophageal-bronchial interaction and suggest that modulation of motility may be of more value than acid suppression in these patients.

  2. Technical Notes

    1. Multi-channel wireless mapping of gastrointestinal serosal slow wave propagation

      N. Paskaranandavadivel, R. Wang, S. Sathar, G. O'Grady, L. K. Cheng and A. Farajidavar

      Article first published online: 20 JAN 2015 | DOI: 10.1111/nmo.12515

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      Validation of gastrointestinal slow wave recordings from a novel multi-channel wireless electrophysiological recording system via a commercial wired system. The development of a novel multi-channel wireless system will allow for studies of slow wave recordings in a chronic state in normal and diseased subjects.

  3. Original Articles

    1. Effect of dietary fat and food consistency on gastroparesis symptoms in patients with gastroparesis

      C. J. Homko, F. Duffy, F. K. Friedenberg, G. Boden and H. P. Parkman

      Article first published online: 19 JAN 2015 | DOI: 10.1111/nmo.12519

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      The aim of this study was to determine the effect of fat intake and solid/liquid meal consistency on symptoms in gastroparesis. This figure shows that a high-fat solid meal increased overall symptoms among individuals with gastroparesis, whereas a low-fat liquid meal had the least effect. These data provide support for recommendations that low-fat and increased liquid content meals are best tolerated in patients with symptomatic gastroparesis.

    2. A ghrelin receptor agonist is an effective colokinetic in rats with diet-induced constipation

      R. V. Pustovit, J. B. Furness and L. R. Rivera

      Article first published online: 19 JAN 2015 | DOI: 10.1111/nmo.12517

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      A rat model exhibiting a constipation phenotype had lowered colorectal responsiveness to distension and to activation of defecation by water avoidance stress. The centrally penetrant ghrelin receptor agonist, capromorelin, effectively stimulated defecation in constipated rats.

    3. Small intestinal bacterial overgrowth: duodenal aspiration vs glucose breath test

      A. Erdogan, S. S. C. Rao, D. Gulley, C. Jacobs, Y. Y. Lee and C. Badger

      Article first published online: 19 JAN 2015 | DOI: 10.1111/nmo.12516

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      The diagnosis of small intestinal bacterial overgrowth (SIBO) remains challenging.

  4. Hot Topics

    1. Vasoactive intestinal peptide is a local mediator in a gut-brain neural axis activating intestinal gluconeogenesis

      F. De Vadder, F. Plessier, A. Gautier-Stein and G. Mithieux

      Article first published online: 13 JAN 2015 | DOI: 10.1111/nmo.12508

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      In this article, we propose a mechanism by which propionate enhances intestinal glucose production. We show that, after a propionate-enriched diet, VIP expression is increased in the submucosal plexus, leading to an increased expression of gluconeogenic genes in the mucosa.

  5. Original Articles

    1. Autonomic nervous system dysregulation in irritable bowel syndrome

      B. Salvioli, G. Pellegatta, M. Malacarne, F. Pace, A. Malesci, M. Pagani and D. Lucini

      Article first published online: 11 JAN 2015 | DOI: 10.1111/nmo.12512

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      Autonomic nervous system (ANS) regulation is altered in patients with irritable bowel syndrome (IBS). The goal of the study was to assess ANS profile and its correlation with somatic perception in patients with IBS. We measured ANS function in 41 IBS patients and 42 healthy controls by means of a user-friendly and indirect non-invasive approach. IBS is associated with marked impairment of vagal regulation indices coupled to elevated subjective stress. Autonomic imbalance may have a role in the pathogenesis of IBS and its assessment may open new perspectives in clinical management of patients.

    2. Symptom-association probability between meal ingestion and abdominal pain in patients with irritable bowel syndrome. Does somatization play a role?

      E. Arsiè, M. Coletta, B. M. Cesana and G. Basilisco

      Article first published online: 11 JAN 2015 | DOI: 10.1111/nmo.12510

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      Patients with IBS often claim that meal ingestion worsens abdominal pain. The findings of this study demonstrate that these two variables are significantly (p < 0.05) associated in 45% of patients. Somatization is a frequent and clinically relevant psychological alteration in patients with IBS. The results of this study confirm that the syndrome is more severe in patients with altered somatization, whose quality of life is impaired. However, somatization does not influence the association between meal ingestion and abdominal pain.

    3. You have full text access to this OnlineOpen article
      Association between health-related quality of life and symptoms in patients with chronic constipation: an integrated analysis of three phase 3 trials of prucalopride

      J. Tack, M. Camilleri, D. Dubois, L. Vandeplassche, A. Joseph and R. Kerstens

      Article first published online: 11 JAN 2015 | DOI: 10.1111/nmo.12505

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      This was an integrated analysis of data from three pivotal multicenter, double-blind, randomized, placebo-controlled, parallel-group trials or prucalopride in patients with chronic constipation. The data from the three trials were pooled, and correlations were assessed for the change from baseline in PAC-QOL overall and satisfaction subscale scores compared with PAC-SYM scores. There was a strong correlation (r = 0.710) between improvement in PAC-SYM and improvement in PAC-QOL scores. PAC-SYM scores also correlated well with the PAC-QOL satisfaction subscale (r = 0.589).

    4. Quality of life one year post-Shiga toxin-producing Escherichia coli O104 infection – A prospective cohort study

      B. Riegel, W. Broicher, K. Wegscheider, V. Andresen, E. Brähler, A. W. Lohse and B. Löwe

      Article first published online: 11 JAN 2015 | DOI: 10.1111/nmo.12503

    5. Gastric emptying scintigraphy results in children are affected by age, anthropometric factors, and study duration

      G. K. Wong, R. J. Shulman and B. P. Chumpitazi

      Article first published online: 4 JAN 2015 | DOI: 10.1111/nmo.12499

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      We determined the effect of age, anthropometrics, and study duration on gastric emptying as measured by 4 h gastric emptying scintigraphy (GES) in 188 children in a retrospective study. In those children who ate all of the meal, younger age and lower weight, height, and body surface area were associated with slower gastric emptying. The differences were magnified by increasing duration of the GES.

    6. Intestinal gas homeostasis: disposal pathways

      M. Mego, A. Bendezú, A. Accarino, J.-R. Malagelada and F. Azpiroz

      Article first published online: 4 JAN 2015 | DOI: 10.1111/nmo.12498

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      Our aim was to compare the proportion of the gas produced by colonic fermentation that is evacuated per anus vs that absorbed into the blood and/or metabolized by gas-consuming microorganisms. In 20 healthy subjects, gas evacuated per anus was collected for 4 h after a flatulogenic test meal either without (basal conditions) or with high-rate infusion of exogenous gas labeled with a gaseous marker into the jejunum to wash-out of the gut the gas produced by bacterial fermentation. Without wash-out, only 23 ± 3% of the gas produced reached the anus, indicating that intestinal gas homeostasis is a highly dynamic process by which a large proportion is rapidly eliminated via alternative pathways.

    7. Digestive, cognitive and hedonic responses to a meal

      C. Malagelada, A. Accarino, L. Molne, S. Mendez, E. Campos, A. Gonzalez, J. R. Malagelada and F. Azpiroz

      Article first published online: 3 JAN 2015 | DOI: 10.1111/nmo.12504

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      Gut dysfunctions may be associated to digestive symptoms, but we hypothesized that the gut can also originate pleasant sensations. In healthy subjects, (n = 42) we measured the digestive (gastric accommodation), cognitive response (conscious sensations) and the hedonic component to a meal (240 mL broth or water as control). The results indicate that when appropriate conditions are met, the response to a meal includes a hedonic dimension involving pleasant sensation of digestive well-being.

    8. Colonic motor abnormalities in slow transit constipation defined by high resolution, fibre-optic manometry

      P. G. Dinning, L. Wiklendt, L. Maslen, V. Patton, H. Lewis, J. W. Arkwright, D. A. Wattchow, D. Z. Lubowski, M. Costa and P. A. Bampton

      Article first published online: 3 JAN 2015 | DOI: 10.1111/nmo.12502

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      Utilizing fiber-optic, high resolution colonic manometry, in patients with slow transit constipation, we have defined the colonic motor abnormalities in response to a high calorie meal. We propose a hypothesis that a possible neuropathy in the extrinsic parasympathetic inputs to the colon of patients with slow transit constipation may exist.

  6. Review Articles

    1. Emerging treatments in Neurogastroenterology: relamorelin: a novel gastrocolokinetic synthetic ghrelin agonist

      M. Camilleri and A. Acosta

      Article first published online: 29 DEC 2014 | DOI: 10.1111/nmo.12490

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      Synthetic ghrelin agonists, predominantly small molecules, are being developed as prokinetic agents that may prove useful in the treatment of GI motility disorders. Relamorelin (RM-131) is a pentapeptide synthetic ghrelin analog that activates the growth hormone secretagogue (GHS)-1a (also called the ghrelin) receptor with approximately sixfold greater potency than natural ghrelin. In this review, we discuss the pharmacokinetics, pharmacodynamics, and potential indications for relamorelin. This new ghrelin analog shows great promise to relieve patients with upper or lower GI motility disorders.

  7. Original Articles

    1. Duodenal rather than antral motility contractile parameters correlate with symptom severity in gastroparesis patients

      K. Barshop, K. Staller, J. Semler and B. Kuo

      Article first published online: 17 DEC 2014 | DOI: 10.1111/nmo.12496

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      Wireless motility capsule testing was used to simultaneously assess gastric and duodenal contractile motility in gastroparesis patients. Gastroparesis symptom severity was assessed using a validated questionnaire. Duodenal—rather than gastric—contractile motility correlated with symptom severity in Gastroparesis patients in two independent cohorts.

    2. Concurrent psychological stress and infectious colitis is key to sustaining enhanced peripheral sensory signaling

      I. Spreadbury, F. Ochoa-Cortes, C. Ibeakanma, N. Martin, D. Hurlbut and S. J. Vanner

      Article first published online: 17 DEC 2014 | DOI: 10.1111/nmo.12497

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      Chronic stress and infectious colitis combine in an additive manner to heighten and prolong the sensitivity of visceral nociceptors. The effect relies on temporal coincidence of stress and infection, does not involve substantial exacerbation of inflammation, and may involve combined direct stress hormone and immune signaling on DRG neurons.

    3. Constipation is not associated with colonic diverticula: a multicenter study in Japan

      E. Yamada, M. Inamori, S. Watanabe, T. Sato, M. Tagri, E. Uchida, E. Tanida, M. Izumi, K. Takeshita, N. Fujisawa, K. Komatsu, J. Hamanaka, A. Kanesaki, N. Matsuhashi and A. Nakajima

      Article first published online: 3 DEC 2014 | DOI: 10.1111/nmo.12478

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      We analyzed the location of colonic diverticula and bowel habits, finding that left-sided diverticula were less frequent in subjects with than without constipation syndrome and right-sided diverticula was nothing to do with bowel habits.

  8. Review Articles

    1. The potential role of behavioral therapies in the management of centrally mediated abdominal pain

      L. Keefer and S. Mandal

      Article first published online: 27 NOV 2014 | DOI: 10.1111/nmo.12474

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      The fear avoidance model of pain is the preferred construct in examination of centrally-mediated abdominal pain conditions. The pain experience is divided between a sensory-discriminative (or the sensation of pain) and motivational-affective component (the perception of pain). Fear is a natural consequence of the motivational-affective dimension, but the way fear is managed will drive prognostic outcomes. Patients who confront their pain with the assistance of therapies will likely recover, while those who avoid the fear experience will exacerbate the disease process through maladaptive behaviors.


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