Gastric ghrelin, GOAT, leptin, and leptinR expression as well as peripheral serotonin are dysregulated in humans with obesity
Y. Ritze, A. Schollenberger, M. Hamze Sinno, N. Bühler, M. Böhle, G. Bárdos, H. Sauer, I. Mack, P. Enck, S. Zipfel, T. Meile, A. Königsrainer, M. Kramer and S. C. Bischoff
Article first published online: 19 JAN 2016 | DOI: 10.1111/nmo.12773
Gastrointestinal hormone release and the regulation of appetite and body weight are thought to be dysbalanced in obesity. We asked whether ghrelin, GOAT, leptin, and leptinR expression demonstrates an increased expression in the stomach tissue and blood and also correlates with elevated inflammatory markers in obese compared with non-obese humans. Our data indicate that obesity causes a dysregulation of gastrointestinal hormones at the tissue level and serum, including a negative correlation with an increased marker of subclinical inflammation.