Diabetic and idiopathic gastroparesis is associated with loss of CD206-positive macrophages in the gastric antrum
M. Grover, C. E. Bernard, P. J. Pasricha, H. P. Parkman, S. J. Gibbons, J. Tonascia, K. L. Koch, R. W. McCallum, I. Sarosiek, W. L. Hasler, L. A. B. Nguyen, T. L. Abell, W. J. Snape, M. L. Kendrick, T. A. Kellogg, T. J. McKenzie, F. A. Hamilton, G. Farrugia and NIDDK Gastroparesis Clinical Research Consortium (GpCRC)
Version of Record online: 9 JAN 2017 | DOI: 10.1111/nmo.13018
Animal studies have highlighted an important role of macrophages in development of delayed gastric emptying. However, their role in human gastroparesis is unclear. Upon assessment of full thickness gastric antrum biopsies, both diabetic and idiopathic gastroparesis patients showed a loss of CD206-positive anti-inflammatory macrophages as compared to controls. This correlated with loss of ICC suggesting a role of innate immune cells in pathophysiology of human gastroparesis.