Neurogastroenterology & Motility

Cover image for Vol. 26 Issue 11

Edited By: Gianrico Farrugia, Magnus Simren and Gary Mawe

Impact Factor: 3.424

ISI Journal Citation Reports © Ranking: 2013: 21/74 (Gastroenterology & Hepatology); 46/194 (Clinical Neurology); 99/251 (Neurosciences)

Online ISSN: 1365-2982

Special Collection: Cannabinoids


From May 2011

Special Collection



Gut feelings about the endocannabinoid system
V. Di Marzo, F. Piscitelli

Stemming from the centuries-old and well known effects of Cannabis on intestinal motility and secretion, research on the role of the endocannabinoid system in gut function and dysfunction has received ever increasing attention since the discovery of the cannabinoid receptors and their endogenous ligands, the endocannabinoids. In this article, some of the most recent developments in this field are discussed, with particular emphasis on new data, most of which are published in Neurogastroenterology & Motility, on the potential tonic endocannabinoid control of intestinal motility, the function of cannabinoid type-1 (CB1) receptors in gastric function, visceral pain, inflammation and sepsis, the emerging role of cannabinoid type-2 (CB2) receptors in the gut, and the pharmacology of endocannabinoid-related molecules and plant cannabinoids not necessarily acting via cannabinoid CB1 and CB2 receptors. These novel data highlight the multi-faceted aspects of endocannabinoid function in the GI tract, support the feasibility of the future therapeutic exploitation of this signaling system for the treatment of GI disorders, and leave space for some intriguing new hypotheses on the role of endocannabinoids in the gut.

The cannabinoid antagonist SR144528 enhances the acute effect of WIN 55,212-2 on gastrointestinal motility in the rat
R. Abalo, P. A. Cabezos, G. Vera, R. Fernández-pujol, M. I. Martín

Cannabinoid 1 receptors modulate intestinal sensory and motor function in rat
B. Yüce, M. Kemmer, G. Qian, M. Müller, A. Sibaev, Y. Li, M. E. Kreis, M. Storr

Differential effects of CB1 neutral antagonists and inverse agonists on gastrointestinal motility in mice
M. A. Storr, M. Bashashati, C. Hirota, V. K. Vemuri, C. M. Keenan, M. Duncan, B. Lutz, K. Mackie, A. Makriyannis, W. K. Macnaughton, K. A.Sharkey

Cannabinoid agonist WIN55,212 in vitro inhibits interleukin-6 (IL-6) and monocyte chemo-attractant protein-1 (MCP-1) release by rat pancreatic acini and in vivo induces dual effects on the course of acute pancreatitis
C. Petrella, S. Agostini, G. S. Alema’, P. Casolini, F. Carpino, C. Giuli, G. Improta, G. Linari, V. Petrozza, M. Broccardo

Cannabinoid-induced reduction in antral pacemaker frequency: a telemetric study in the ferret
N. Percie Du Sert, W.-S. V. Ho, J. A. Rudd, P. L. R. Andrews

The cannabinoid receptor agonist delta-9- tetrahydrocannabinol does not affect visceral sensitivity to rectal distension in healthy volunteers and IBS patients
T. K. Klooker, K. E. M. Leliefeld, R. M. Van Den Wijngaard, G. E. E. Boeckxstaens

Activation of the cannabinoid 2 (CB2) receptor inhibits murine mesenteric afferent nerve activity
K. Hillsley, C. Mccaul, J. Aerssens, P. J. Peeters, H. Gijsen, D. Moechars, B. Coulie, D. Grundy, R. H. Stead

Cannabinoid type 1 receptor modulates intestinal propulsion by an attenuation of intestinal motor responses within the myenteric part of the peristaltic reflex
B. Yuece, A. Sibaev, U. C. Broedl, G. Marsicano, B. Göke, B. Lutz, H. D. Allescher, M. Storr

Effect of cannabidiol on sepsis-induced motility disturbances in mice: involvement of CB1 receptors and fatty acid amide hydrolase
D. De Filippis, T. Iuvone, A. D'amico, G. Esposito, L. Steardo, A. G. Herman, P. A. Pelckmans, B. Y. De Winter and J. G. De Man

The identification of peroxisome proliferator-activated receptor alpha-independent effects of oleoylethanolamide on intestinal transit in mice
N. L. Cluny, C. M. Keenan, B. Lutz, D. Piomelli and K. A. Sharkey

Cannabinoid receptor 1 signalling dampens activity and mitochondrial transport in networks of enteric neurones
W. Boesmans, K. Ameloot, V. Van Den Abbeel, J. Tack and P. Vanden Berghe

Selective lack of tolerance to delayed gastric emptying after daily administration of WIN 55,212-2 in the rat
R. Abalo, P. A. Cabezos, V. López-miranda, G. Vera, C. González, M. Castillo, R. Fernández-pujol and M. I. Martín

Salvinorin A inhibits colonic transit and neurogenic ion transport in mice by activating j-opioid and cannabinoid receptors
J. Fichna, R. Schicho, C. N. Andrews, M. Bashashati, M. Klompus, D. M. Mckay, K. A. Sharkey, J. K. Zjawiony, A. Janecka and M. A. Storr

Involvement of cannabinoid-1 and cannabinoid-2 receptors in septic ileus
Y.-y. Li, Y.-n. Li, J.-b. Ni, C.-j. Chen, S. Lv, S.-y. Chai, R.-h. Wu, B. Yüce and M. Storr

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